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Neurochemical Research

Xiaofan Yang, Pingping Xue, Ruozheng Wei, Xin Liu, Xiang Xu, Zhenyu Liu, Yanhua Chen, Zhenbing Chen
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation...
January 16, 2018: Neurochemical Research
Tomas Monfil, Rubén Antonio Vázquez Roque, Israel Camacho-Abrego, Hiram Tendilla-Beltran, Tommaso Iannitti, Ivan Meneses-Morales, Patricia Aguilar-Alonso, Gonzalo Flores, Julio Cesar Morales-Medina
The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected.
January 13, 2018: Neurochemical Research
Mehreen Rahman, Haiyun Luo, Neil R Sims, Larisa Bobrovskaya, Xin-Fu Zhou
Treatment with mature brain-derived neurotrophic factor (mBDNF) promotes functional recovery after ischemia in animal trials but the possible role of its precursor protein proBDNF and its receptors or the factors responsible for the conversion of proBDNF to mBDNF in ischemic stroke are not known. The main aim of this study was to characterize the time-dependent expression of genes and/or proteins related to BDNF processing and signaling after ischemia as well as the sensorimotor behavioral dysfunction in a photothrombotic ischemic model in rats...
January 12, 2018: Neurochemical Research
Katerina Apostolopoulou, Dimitris Konstantinou, Rodoula Alataki, Ioannis Papapostolou, Dimitrios Zisimopoulos, Electra Kalaitzopoulou, Vasiliki Bravou, Ioannis Lilis, Fevronia Angelatou, Helen Papadaki, Christos D Georgiou, Elisabeth Chroni
An ischemia/reperfusion injury of rat's sciatic nerve was experimentally developed. In this model, we measured the in vivo production of superoxide radical, as a marker of oxidative stress and the occludin expression as an indicator of blood-nerve barrier function and we examined potential protective innervations against these abnormalities. Right sciatic nerves of the animals underwent 3 h of ischemia followed by 7 days of reperfusion and were divided into three groups: ischemic, pretreated with vitamin C in conjunction with vitamin E and treated with tissue plasminogen activator...
January 11, 2018: Neurochemical Research
Jung Mi Lim, Geumsoo Kim, Rodney L Levine
Methionine in proteins is often thought to be a generic hydrophobic residue, functionally replaceable with another hydrophobic residue such as valine or leucine. This is not the case, and the reason is that methionine contains sulfur that confers special properties on methionine. The sulfur can be oxidized, converting methionine to methionine sulfoxide, and ubiquitous methionine sulfoxide reductases can reduce the sulfoxide back to methionine. This redox cycle enables methionine residues to provide a catalytically efficient antioxidant defense by reacting with oxidizing species...
January 11, 2018: Neurochemical Research
S Niveditha, S R Ramesh, T Shivanandappa
The original version of this article unfortunately contained a mistake. The entries missing in the reference list are given below and their corresponding citations are provided in the Discussion section text.
January 9, 2018: Neurochemical Research
Chunxia Chen, Qiuping Fan, Zhihuan Nong, Wan Chen, Yaoxuan Li, Luying Huang, Daorong Feng, Xiaorong Pan, Shengyong Lan
In this study, we examined whether hyperbaric oxygen (HBO2) plays a detoxification role in withdrawal symptoms in a morphine-dependent rat model. The model was established through injections of morphine at increasing doses for 7 days. Withdrawal symptoms were induced by naloxone injection on the 8th day. The detoxification effect of HBO2 was evaluated using the withdrawal symptom scores, biochemical indices and neurotransmitters. Compared with the model group, HBO2 therapy significantly attenuated the withdrawal symptom scores, body weight loss and the level of norepinephrine level, whereas it increased the dopamine level and tyrosine hydroxylase expression in the nucleus accumbens...
January 8, 2018: Neurochemical Research
Yijia Shen, Dai Li, Bo Li, Peng Xi, Yun Zhang, Youshui Jiang, Yehao Xu, Hui Chen, Yuanchang Xiong
Chronic postsurgical pain (CPSP) often occurs after surgery and has a strong impact on patients' daily lives. However, the underlying mechanism of CPSP remains unknown. Here, we used a skin/muscle incision and retraction (SMIR) model to investigate the role of CX3CL1 in SMIR-induced pain and its underlying mechanism. We found that up-regulation of CX3CL1 in the spinal dorsal horn contributed to SMIR-induced mechanical allodynia. The use of a CX3CL1-neutralizing antibody to block CX3CL1 attenuated mechanical allodynia induced by SMIR surgery...
January 8, 2018: Neurochemical Research
Mickaël Naassila, Olivier Pierrefiche
The glutamatergic system plays a central role in both the acute and chronic effects of ethanol. Among all the glutamate receptors the ionotropic NMDA receptors are crucial because of their role in synaptic plasticity. A large body of evidences suggests that short-term and long-term effects of ethanol may change synaptic plasticity via an alteration of the expression of the GluN2B subunit, one constitutive element of the NMDA receptor. The present review is focusing on the role of the GluN2B subunit after ethanol exposure during early life (in utero and adolescence) and also at adulthood...
January 6, 2018: Neurochemical Research
Jolene M Kim, Elizabeth Billington, Ada Reyes, Tara Notarianni, Jessica Sage, Emre Agbas, Michael Taylor, Ian Monast, John A Stanford, Abdulbaki Agbas
Impaired interactions between Calcineurin (Cn) and (Cu/Zn) superoxide dismutase (SOD1) are suspected to be responsible for the formation of hyperphosphorylated protein aggregation in amyotrophic lateral sclerosis (ALS). Serine (Ser)- enriched phosphorylated TDP-43 protein aggregation appears in the spinal cord of ALS animal models, and may be linked to the reduced phosphatase activity of Cn. The mutant overexpressed SOD1G93A protein does not properly bind zinc (Zn) in animal models; hence, mutant SOD1G93A-Cn interaction weakens...
January 3, 2018: Neurochemical Research
Cynthia Sámano, Andrea Nistri
Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological neuroprotection should be one major strategy whose impact may be first studied with preclinical models. Using a simple in vitro model of the rat spinal cord it is possible to mimic pathological processes like excitotoxicity that damages neurons because of excessive glutamate receptor activation due to injury, or hypoxic/dysmetabolic insult that preferentially affects glia following vascular dysfunction...
December 30, 2017: Neurochemical Research
Úrzula Franco-Enzástiga, Ricardo A Santana-Martínez, Carlos A Silva-Islas, Diana Barrera-Oviedo, María Elena Chánez-Cárdenas, Perla D Maldonado
The original version of this article unfortunately contained a mistake.
December 26, 2017: Neurochemical Research
Ashley J Evans, Sonam Gurung, Jeremy M Henley, Yasuko Nakamura, Kevin A Wilkinson
Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease...
December 21, 2017: Neurochemical Research
Jianzheng Zheng, Che-Lin Hu, Kara L Shanley, Oscar A Bizzozero
This study was conducted to further our understanding about the link between lipid peroxidation and protein carbonylation in rat brain slices incubated with the glutathione (GSH)-depletor diethyl maleate. Using this in vitro system of oxidative stress, we found that there is a significant lag between the appearance of carbonylated proteins and GSH depletion, which seems to be due to the removal of oxidized species early on in the incubation by the mitochondrial Lon protease. Upon acute GSH depletion, protein carbonyls accumulated mostly in mitochondria and to a lesser degree in other subcellular fractions that also contain high levels of polyunsaturated lipids...
December 20, 2017: Neurochemical Research
Bai Hui Chen, Ji Hyeon Ahn, Joon Ha Park, Soo Young Choi, Yun Lyul Lee, Il Jun Kang, In Koo Hwang, Tae-Kyeong Lee, Bich-Na Shin, Jae-Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Young Joo Lee
It has been demonstrated that melatonin plays important roles in memory improvement and promotes neurogenesis in experimental animals. We examined effects of melatonin on cognitive deficits, neuronal damage, cell proliferation, neuroblast differentiation and neuronal maturation in the mouse dentate gyrus after cotreatment of scopolamine (anticholinergic agent) and melatonin. Scopolamine (1 mg/kg) and melatonin (10 mg/kg) were intraperitoneally injected for 2 and/or 4 weeks to 8-week-old mice. Scopolamine treatment induced significant cognitive deficits 2 and 4 weeks after scopolamine treatment, however, cotreatment of scopolamine and melatonin significantly improved spatial learning and short-term memory impairments...
December 19, 2017: Neurochemical Research
Ting Li, Ziqiang Luo, Yang Liu, Mingjie Wang, Xiaohe Yu, Chuanding Cao, Zhengchang Liao, Ying Ding, Shaojie Yue
Intrauterine hypoxia is one of the most common stressors in fetuses, which can lead to abnormal brain development and permanent neurological deficits in adulthood. Neurological disorder excitotoxicity induced by hypoxia or ischemia may involve N-methyl-D-aspartate receptors (NMDARs), which are known to participate in the maturation and plasticity of developmental neurons. Inhibition of NMDARs has been reported to improve neurological outcomes in traumatic brain injuries and Alzheimer's disease. Here, we investigated if antenatal blockade of NMDARs induced by memantine could alleviate neurodevelopmental brain damage and long-term cognitive deficits in intrauterine hypoxia rats...
December 19, 2017: Neurochemical Research
Weijun Gong, Shuyan Qie, Peiling Huang, Jianing Xi
To explore the effect of microRNA-374a (miR-374a) on chemical hypoxia-induced pheochromocytoma (PC12) cell damage by mediating growth arrest and the DNA damage-45 alpha (GADD45α)/c-Jun N-terminal kinase (JNK) signaling pathway. PC12 cells were divided into a Control group (no treatment), Model group (treated with CoCl2 for 24 h), negative control (NC) group (transfected with miR-374a negative control sequence and treated with CoCl2 for 24 h), and miR-374a mimic group (transfected with miR-374a mimics and treated with CoCl2 for 24 h)...
December 15, 2017: Neurochemical Research
Abdulkerim Kasim Baltaci, Kemal Yuce
Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes...
December 14, 2017: Neurochemical Research
Qinrui Li, Ying Han, Junbao Du, Hongfang Jin, Jing Zhang, Manman Niu, Jiong Qin
Epilepsy is among the most common neurological disorders. Recurrent seizures result in neuronal death, cognitive deficits and intellectual disabilities in children. Currently, recombinant human erythropoietin (rhEPO) is considered to play a neuroprotective role in nervous system disorders. However, the precise mechanisms through which rhEPO modulates epilepsy remain unknown. Based on results from numerous studies, we hypothesized that rhEPO protects against hippocampal damage in developing rats with seizures probably by modulating autophagy via the ribosomal protein S6 (S6) in a time-dependent manner...
December 13, 2017: Neurochemical Research
Christabel Fung-Yih Ho, Claire Poh-Ee Bon, Yee-Kong Ng, Deron R Herr, Jui-Sheng Wu, Teng-Nan Lin, Wei-Yi Ong
The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety. In this study, we elucidated epigenetic regulation of Alox15 via histone modifications in neuron-like cells. Treatment of undifferentiated SH-SY5Y human neuroblastoma cells with the histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate significantly increased Alox15 mRNA expression...
December 12, 2017: Neurochemical Research
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