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Psychoneuroendocrinology

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https://www.readbyqxmd.com/read/28448821/the-implications-of-war-captivity-and-long-term-psychopathology-trajectories-for-telomere-length
#1
Zahava Solomon, Noga Tsur, Yafit Levin, Orit Uziel, Meir Lahav, Avi Ohry
BACKGROUND: Previous findings have demonstrated the link between trauma, its psychopathological aftermath and cellular aging, as reflected in telomere length. However, as long-term examinations of psychopathology following trauma are scarce, very little is known regarding the repercussions of depression and PTSD trajectories of psychopathology for telomeres. The current study examined the implications of war captivity and depression/PTSD trajectories on telomere length. METHODS: Ninety-nine former prisoners of war (ex-POWs) from the 1973 Yom Kippur War were evaluated for depression and PTSD at 18, 30, 35 and 42 years after the war...
April 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28453978/oxytocin-attenuates-social-and-non-social-avoidance-re-thinking-the-social-specificity-of-oxytocin
#2
Osnat Harari-Dahan, Amit Bernstein
Re-examining decades of the social construal of Oxytocin, the General Approach-Avoidance Hypothesis of Oxytocin (GAAO) predicts that Oxytocin will modulate responding to emotionally-evocative and personally-relevant social and non-social stimuli due to its action on the neural substrate of approach and avoidance motivation. We report the first critical experimental test of GAAO predictions by means of a double-blind intra-nasal administration of Oxytocin vs. placebo in 90 healthy adults (N=90, 50% women). As predicted, we found that among men and women for whom negative emotion (anxious arousal) is motivationally-relevant, intra-nasal administration of Oxytocin reduced behavioral avoidance of emotionally-evocative negatively-valenced social and non-social stimuli, but not closely matched emotionally-neutral stimuli...
April 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28433802/role-of-environmental-stressors-in-determining-the-developmental-outcome-of-neonatal-anesthesia
#3
Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N Seubert, Timothy E Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E Martynyuk
BACKGROUND: The majority of studies evaluating neurocognition in humans who had procedures under anesthesia early in life found long-term deficits even though the typical anesthesia duration normalized to the human life span is much shorter than that shown to induce developmental abnormalities in rodents. Therefore, we studied whether subsequent environmental stressors contribute to deficiencies programmed by a brief neonatal etomidate exposure. METHODS: Postnatal days (P) 4, 5, or 6, Sprague-Dawley rats, pretreated with vehicle or the Na(+)-K(+)-2Cl(-) (NKCC1) inhibitor, bumetanide, received two injections of etomidate resulting in anesthesia for 2h...
April 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28412582/sex-differences-in-neural-activation-following-different-routes-of-oxytocin-administration-in-awake-adult-rats
#4
Kelly M Dumais, Praveen P Kulkarni, Craig F Ferris, Alexa H Veenema
The neuropeptide oxytocin (OT) regulates social behavior in sex-specific ways across species. OT has promising effects on alleviating social deficits in sex-biased neuropsychiatric disorders. However little is known about potential sexually dimorphic effects of OT on brain function. Using the rat as a model organism, we determined whether OT administered centrally or peripherally induces sex differences in brain activation. Functional magnetic resonance imaging was used to examine blood oxygen level-dependent (BOLD) signal intensity changes in the brains of awake rats during the 20min following intracerebroventricular (ICV; 1μg/5μl) or intraperitoneal (IP; 0...
April 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28410838/reply-to-the-commentary-by-parrot-and-downey-2017
#5
LETTER
Tobias Stalder, Susann Steudte-Schmiedgen, Nina Alexander, Tim Klucken, Annika Vater, Susann Wichmann, Clemens Kirschbaum, Robert Miller
No abstract text is available yet for this article.
April 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28419913/depression-and-anxiety-both-associate-with-serum-level-of-hs-crp-a-gender-stratified-analysis-in-a-population-based-study
#6
Maryam Tayefi, Mojtaba Shafiee, Seyyed Mohammad Reza Kazemi-Bajestani, Habibolah Esmaeili, Susan Darroudi, Samaneh Khakpouri, Maryam Mohammadi, Zahra Ghaneifar, Mahmoud Reza Azarpajouh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mohammad Reza Parizadeh, Mohsen Nematy, Mohammad Safarian, Mahmoud Ebrahimi, Gordon A Ferns, Naghmeh Mokhber, Majid Ghayour-Mobarhan
BACKGROUND: Depression and anxiety are two important mood disorders that are frequently associated with chronic diseases such as cardiovascular diseases (CVDs). Hyper-inflammation is related to both CVDs and psychological conditions such as depression and anxiety. Therefore, inflammation may partially explain the relationship between depression and cardiovascular disease. OBJECTIVE: The objective of this study was to perform a gender-stratified examination of the association between symptoms of depression/anxiety disorders and serum hs-CRP and inflammation linked conditions in a large Iranian population...
April 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28433801/moderate-within-person-variability-in-cortisol-is-related-to-executive-function-in-early-childhood
#7
Clancy Blair, Daniel J Berry
Lab-based experimental studies with humans and in animal models demonstrate that the relation between glucocorticoid (GC) levels and performance on measures of higher-order cognitive ability such as executive function (EF) is best described by an inverted U-shape curve. Moderate levels of GCs (cortisol/corticosterone) are associated with comparatively better performance relative to GC levels that are particularly high or low. Although findings from experimental studies are definitive and have high internal validity, the external validity of this association as an aspect of children's development is unknown...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28431278/intranasal-oxytocin-does-not-modulate-jumping-to-conclusions-in-schizophrenia-potential-interactions-with-caudate-volume-and-baseline-social-functioning
#8
Fernando Caravaggio, Philip Gerretsen, Wanna Mar, Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Julia Kim, Yusuke Iwata, Raihaan Patel, M Mallar Chakravarty, Gary Remington, Ariel Graff-Guerrero, Mahesh Menon
BACKGROUND: Patients with schizophrenia (SCZ) tend to sample less information when making a decision, jumping to conclusions (JTC) without sufficient evidence. This "JTC bias" may be a trait marker of the disease and may not improve with antipsychotic treatment. We conducted a double-blind, placebo-controlled trial to test whether intranasal oxytocin could reduce JTC in stable, medicated patients with SCZ and healthy controls (HCs). We also explored whether striatal volume, clinical symptoms, and baseline social functioning (SF) was related to JTC performance...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28407517/social-status-strategy-in-early-adolescent-girls-testosterone-and-value-based-decision-making
#9
Stephanie L Cardoos, Ahna Ballonoff Suleiman, Megan Johnson, Wouter van den Bos, Stephen P Hinshaw, Ronald E Dahl
There has been strong interest, spanning several disciplines, in understanding adolescence as a developmental period of increased risk-taking behavior. Our goals focus on one line of investigation within this larger developmental risk framework. Specifically, we examined levels of pubertal hormones in girls in relation to their willingness to take greater financial risks to gain social status. To this end, we tested the hypothesis that higher levels of testosterone during the ages of pubertal maturation are associated with a greater willingness to sacrifice money for social admiration...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28395185/kindness-in-the-blood-a-randomized-controlled-trial-of-the-gene-regulatory-impact-of-prosocial-behavior
#10
S Katherine Nelson-Coffey, Megan M Fritz, Sonja Lyubomirsky, Steve W Cole
CONTEXT: Prosocial behavior is linked to longevity, but few studies have experimentally manipulated prosocial behavior to identify the causal mechanisms underlying this association. One possible mediating pathway involves changes in gene expression that may subsequently influence disease development or resistance. DESIGN, SETTING, PARTICIPANTS: In the current study, we examined changes in a leukocyte gene expression profile known as the Conserved Transcriptional Response to Adversity (CTRA) in 159 adults who were randomly assigned for 4 weeks to engage in prosocial behavior directed towards specific others, prosocial behavior directed towards the world in general, self-focused kindness, or a neutral control task...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28419914/longitudinal-changes-in-pubertal-maturation-and-white-matter-microstructure
#11
Megan M Herting, Robert Kim, Kristina A Uban, Eric Kan, Andrea Binley, Elizabeth R Sowell
Emerging evidence in the field of adolescent neurodevelopment suggests that pubertal processes may contribute to known trajectories of brain maturation, and may contribute, in part, to sex differences in related cognitive, behavioral and mental health outcomes. The current longitudinal study examined how changes in physical pubertal maturation (measured by the Peterson Developmental Scale) predict changes in white matter microstructure in 18 boys and 15 girls over an approximate 2-year follow-up period, while accounting for age...
March 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28413131/distress-stress-disentangling-the-different-components-of-emotional-experience
#12
Julia Diemer
No abstract text is available yet for this article.
March 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28410837/diurnal-salivary-cortisol-levels-and-slopes-in-a-community-sample-of-healthy-adults-is-current-research-conclusive
#13
LETTER
Vaitsa Giannouli
No abstract text is available yet for this article.
March 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28392096/psychoactive-drug-influences-on-hair-cortisol
#14
LETTER
Andrew C Parrott, Luke A Downey
No abstract text is available yet for this article.
March 29, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28408055/a-lesson-in-controlling-for-third-factors-and-reading-before-you-write-a-reply-to-giannouli
#15
LETTER
Sheldon Cohen, Brian Chin, Michael L M Murphy, Denise Janicki-Deverts
No abstract text is available yet for this article.
March 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28411413/sexual-intimacy-in-couples-is-associated-with-longer-telomere-length
#16
Tomás Cabeza de Baca, Elissa S Epel, Theodore F Robles, Michael Coccia, Amanda Gilbert, Eli Puterman, Aric A Prather
High-quality relationships have been shown to be beneficial for physical and mental health. This study examined overall relationship satisfaction and perceived stress as well as daily reports of partner support, partner conflict, and physical intimacy obtained over the course of one week in a sample of 129 high and low stress mothers. Telomere length was examined in whole blood, as well as the two cell subpopulations: peripheral blood mononuclear cells (PBMCs) and granulocytes. Telomerase activity was measured in PBMCs...
March 25, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28411411/maternal-hypothyroxinaemia-in-early-pregnancy-and-problem-behavior-in-5-year-old-offspring
#17
Maurits H W Oostenbroek, Remco H J Kersten, Benjamin Tros, Anton E Kunst, Tanja G M Vrijkotte, Martijn J J Finken
INTRODUCTION: There is evidence, though not consistent, that offspring born to mothers with subtle decreases in thyroid function early in their pregnancies may be at risk of cognitive impairments and attention problems. However, other types of problem behavior have not been addressed thus far. We tested whether maternal thyroid function in early pregnancy is associated with several types of problem behavior in offspring at age 5-6 years. METHODS: This was a longitudinal study that included the data of 2000 mother-child pairs from the Amsterdam Born Children and their Development study...
March 25, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28411412/individual-differences-in-the-activity-of-the-hypothalamic-pituitary-adrenal-axis-relations-to-age-and-cumulative-risk-in-early-childhood
#18
Steven J Holochwost, Jean-Louis Gariépy, W Roger Mills-Koonce, Cathi B Propper, Jacek Kolacz, Douglas A Granger
This study examined individual differences in the function of the hypothalamic-pituitary-adrenal (HPA) axis with regard to age and cumulative risk during challenging laboratory tasks administered at 6, 12, 24, and 36 months. Saliva samples were collected from a majority-minority sample of N=185 children (57% African American, 50% female) prior to and following these tasks and later assayed for cortisol. Cumulative distal risk was indexed via a composite of maternal marital status, maternal education, income-to-needs ratio, the number of children in the household, and maternal age at childbirth...
March 24, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28391069/insulin-and-glucagon-in-plasma-and-cerebrospinal-fluid-in-suicide-attempters-and-healthy-controls
#19
Marie Bendix, Kerstin Uvnäs-Moberg, Maria Petersson, Viktor Kaldo, Marie Åsberg, Jussi Jokinen
Mental disorders and related behaviors such as suicidality and violence have been associated to dysregulation of e g carbohydrate metabolism. We hypothesized that patients after suicide attempt, compared to healthy controls, would have higher insulin and lower glucagon levels in plasma and cerebrospinal fluid and that these changes would be associated to violent behavior. Twenty-eight medication-free patients (10 women, 18 men), hospitalized after suicide attempt, and 19 healthy controls (7 women, 12 men) were recruited with the aim to study risk factors for suicidal behavior...
March 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28426945/testosterone-levels-in-healthy-men-correlate-negatively-with-serotonin-4-receptor-binding
#20
Erik Perfalk, Sofi da Cunha-Bang, Klaus K Holst, Sune Keller, Claus Svarer, Gitte M Knudsen, Vibe G Frokjaer
The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Here we evaluate if peripheral levels of estradiol and testosterone are associated with 5-HT4R binding as imaged by [(11)C]SB207145 positron emission tomography in a group of 41 healthy men...
March 22, 2017: Psychoneuroendocrinology
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