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Psychoneuroendocrinology

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https://www.readbyqxmd.com/read/29787958/altered-tryptophan-catabolite-concentrations-in-major-depressive-disorder-and-associated-changes-in-hippocampal-subfield-volumes
#1
Kelly Doolin, Kelly A Allers, Sina Pleiner, Andre Liesener, Chloe Farrell, Leonardo Tozzi, Erik O'Hanlon, Darren Roddy, Thomas Frodl, Andrew Harkin, Veronica O'Keane
BACKGROUND: Tryptophan depletion is a well-replicated biological finding in Major Depressive Disorder (MDD). The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the pathogenesis of depression. IDO expression is driven by inflammatory cytokines, providing a putative link between inflammation and neuropathology. This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC)...
May 19, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29783162/a-peripheral-immune-response-to-remembering-trauma-contributes-to-the-maintenance-of-fear-memory-in-mice
#2
Matthew B Young, Leonard L Howell, Lauren Hopkins, Cassandra Moshfegh, Zhe Yu, Lauren Clubb, Jessica Seidenberg, Jeanie Park, Adam P Swiercz, Paul J Marvar
Alterations in peripheral immune markers are observed in individuals with post-traumatic stress disorder (PTSD). PTSD is characterized in part by impaired extinction of fear memory for a traumatic experience. We hypothesized that fear memory extinction is regulated by immune signaling stimulated when fear memory is retrieved. The relationship between fear memory and the peripheral immune response was tested using auditory Pavlovian fear conditioning in mice. Memory for the association was quantified by the amount of conditioned freezing exhibited in response to the conditioned stimulus (CS), extinction and time-dependent changes in circulating inflammatory cytokines...
May 17, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775873/psychosocial-stress-and-inflammation-driving-tryptophan-breakdown-in-children-and-adolescents-a-cross-sectional-analysis-of-two-cohorts
#3
Nathalie Michels, Gerard Clarke, Loreto Olavarria-Ramirez, Sonia Gómez-Martínez, Ligia Esperanza Díaz, Ascensión Marcos, Kurt Widhalm, Livia A Carvalho
BACKGROUND: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress-induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown. Depression is a major public health problem which commonly starts during adolescence, thus identifying underlying mechanisms during early life is crucial in prevention. The aim of this work was to verify whether independent and interacting associations of psychosocial stress and inflammation on tryptophan breakdown already exist in children and adolescents as a vulnerable age group...
May 15, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29787957/prolonged-performance-related-neuroendocrine-activation-and-perseverative-cognition-in-low-and-high-anxious-university-music-students
#4
Patrick Gomez, Carole Nielsen, Regina K Studer, Horst Hildebrandt, Petra L Klumb, Urs M Nater, Pascal Wild, Brigitta Danuser
Music performances are social-evaluative situations that can elicit marked short-term neuroendocrine activation and anxious thoughts especially in musicians suffering from music performance anxiety (MPA). The temporal patterns of neuroendocrine activity and concert-related worry and rumination (perseverative cognition, PC) days before and after a concert in low- and high-anxious musicians are unknown. The first goal of the present study was to investigate the prolonged effects of a solo music performance and the effects of trait MPA on salivary cortisol (sC), alpha-amylase (sAA), and concert-related PC...
May 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775875/the-reduced-level-of-growth-factors-in-an-animal-model-of-depression-is-accompanied-by-regulated-necrosis-in-the-frontal-cortex-but-not-in-the-hippocampus
#5
Mateusz Kucharczyk, Anna Kurek, Bartosz Pomierny, Jan Detka, Mariusz Papp, Katarzyna Tota, Bogusława Budziszewska
In the present study, we asked if the different types of stress alter neuronal plasticity markers distinctively in the frontal cortex (FCx) and in the hippocampus (Hp). To do so, we implemented various stress regimens to analyze changes evoked in these rat brain structures. We utilized several molecular techniques, including western blot, ELISA, quantitative RT-PCR, and various biochemical assays, to examine a range of proteins and subjected rats to behavioral tests to evaluate potential maladaptive alterations...
May 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29783087/association-of-t-and-non-t-cell-cytokines-with-anhedonia-role-of-gender-differences
#6
Manish K Jha, Andrew H Miller, Abu Minhajuddin, Madhukar H Trivedi
OBJECTIVE: Among individual depressive symptoms, anhedonia has been reliably associated with activation of the innate immune response. However, it is unclear whether this association extends to T cell cytokines and if gender differentially affects this association. METHOD: Concentrations of T (IL-17, T-helper (Th) 1- and Th2-) and non-T cell cytokines were measured in plasma using the Bioplex Pro™ human cytokine multiplex kit in Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided plasma at baseline (n = 166)...
May 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775877/communication-and-social-interaction-anxiety-enhance-interleukin-1-beta-and-cortisol-reactivity-during-high-stakes-public-speaking
#7
Brandon J Auer, Jessica L Calvi, Nicolas M Jordan, David Schrader, Jennifer Byrd-Craven
BACKGROUND: Worry or fear related to speaking in front of others, or more broadly, communicating and interacting with others, is common. At elevated levels, however, it may contribute to heightened stress reactivity during acute speaking challenges. The purpose of this study was to examine multi-system physiological stress reactivity in the context of high-stakes public speaking while considering the impact of hypothesized individual difference risk factors. METHODS: University student participants (n = 95) delivering speeches as a heavily-weighted component of their final grade had saliva samples collected immediately prior to speaking, immediately after, and 20 min after speech completion...
May 8, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775878/repositioning-of-diabetes-treatments-for-depressive-symptoms-a-systematic-review-and-meta-analysis-of-clinical-trials
#8
REVIEW
Calum D Moulton, Christopher W P Hopkins, Khalida Ismail, Daniel Stahl
Depression is a common comorbidity in diabetes but conventional antidepressant treatments do not consistently improve outcomes. We tested whether established diabetes treatments can also improve depressive symptoms and examined biological correlates of response. We performed a multi-database systematic search of all clinical trials, which measured the effect of licensed diabetes treatments on depressive symptoms using a validated questionnaire. Results of randomised controlled trials (RCT's) were pooled for meta-analysis...
May 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29753175/changes-in-the-tryptophan-kynurenine-axis-in-association-to-therapeutic-response-in-clinically-depressed-patients-undergoing-psychiatric-rehabilitation
#9
B Reininghaus, K Riedrich, N Dalkner, S A Bengesser, A Birner, M Platzer, C Hamm, J M Gostner, D Fuchs, E Z Reininghaus
INTRODUCTION: In recent decades a number of studies have shown an association between the Tryptophan (Trp)-Kynurenine (Kyn) axis and neuropsychiatric disorders. However, the role of the Trp-Kyn pathway on the affective status in a general psychiatric cohort requires clarification. This study aimed to measure peripheral changes in Trp, Kyn and the Kyn/Trp-ratio as well as in the inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukine-6 (IL-6) in individuals undergoing a six-week course of intensive treatment program comparing subgroups of treatment responders and non-responders...
May 6, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29763783/sex-differences-in-the-acth-and-cortisol-response-to-pharmacological-probes-are-stressor-specific-and-occur-regardless-of-alcohol-dependence-history
#10
Robert M Anthenelli, Jaimee L Heffner, Thomas J Blom, Belinda E Daniel, Benjamin S McKenna, Gary S Wand
Women and men differ in their risk for developing stress-related conditions such as alcohol use and anxiety disorders and there are gender differences in the typical sequence in which these disorders co-occur. However, the neural systems underlying these gender-biased psychopathologies and clinical course modifiers in humans are poorly understood and may involve both central and peripheral mechanisms regulating the limbic-hypothalamic-pituitary-adrenal axis. In the present randomized, double blind, placebo-controlled, triple-dummy crossover study, we juxtaposed a centrally-acting, citalopram (2 mg/unit BMI) neuroendocrine stimulation test with a peripherally-acting, dexamethasone (Dex) (1...
May 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29754003/stress-induced-pro-and-anti-inflammatory-cytokine-concentrations-in-panic-disorder-patients
#11
Katja Petrowski, Susann Wichmann, Clemens Kirschbaum
BACKGROUND: An attenuated responsivity of the hypothalamus-hypophysis-adrenal (HPA) axis upon challenge and an increased risk for cardiac events are relatively consistent findings in panic disorder (PD) patients. Due to cytokine-HPA interactions, an altered HPA-axis responsivity may be accompanied by altered cytokine concentrations. Immunological reactions under stress might be considered the missing link for explaining an increased cardiac risk. This study analyzed stress-induced cytokine levels in PD patients...
May 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29751249/stressful-life-events-predict-one-year-change-of-leukocyte-composition-in-peripheral-blood
#12
Marlene Penz, Clemens Kirschbaum, Angelika Buske-Kirschbaum, Magdalena K Wekenborg, Robert Miller
A plethora of cross-sectional studies suggest that psychological stress resulting from experiencing stressful life events (SLE) can result in an altered immune response. Potential maladaptive immune changes may outlast the event and affect the organism long after stress cessation. As a consequence, an increased vulnerability for immune-mediated pathologies (e.g. arthritis, diabetes) may develop over the life span. The objective of the present study was to monitor the longitudinal kinetics of peripheral white blood cells (WBCs; neutrophils, lymphocytes, and monocytes) in response to SLE...
May 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29758470/association-between-changes-in-heart-rate-variability-during-the-anticipation-of-a-stressful-situation-and-the-stress-induced-cortisol-response
#13
Matias M Pulopulos, Marie-Anne Vanderhasselt, Rudi De Raedt
Vagal activity - reflecting the activation of stress regulatory mechanisms and prefrontal cortex activation - is thought to play an inhibitory role in the regulation of the hypothalamus-pituitary-adrenal axis. However, most studies investigating the association between stress-induced changes in heart rate variability (HRV, an index of cardiac vagal tone) and cortisol have shown a non-significant relationship. It has been proposed that physiological changes observed during anticipation of a stressor allow individuals to make behavioral, cognitive, and physiological adjustments that are necessary to deal with the upcoming actual stressor...
May 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29731382/corrigendum-to-insulin-and-glucagon-in-plasma-and-cerebrospinal-fluid-in-suicide-attempters-and-healthy-controls-psychoneuroendocrinology-81-2017-1-7
#14
Marie Bendix, Kerstin Uvnäs-Moberg, Maria Petersson, Viktor Kaldo, Marie Åsberg, Jussi Jokinen
No abstract text is available yet for this article.
May 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29738960/verbal-and-physical-client-aggression-a-longitudinal-analysis-of-professional-caregivers-psychophysiological-stress-response-and-burnout
#15
Nina Kind, Anne Eckert, Célia Steinlin, Jörg M Fegert, Marc Schmid
OBJECTIVE: We investigated the impact of verbal and physical client aggression on risk of developing high hair cortisol concentration (HCC) as an indicator of chronic stress exposure and burnout in a Swiss population of professional caregivers working in youth residential care. METHOD: Participants (n = 121; 62.0% women) reported on client aggression and burnout symptoms and provided hair samples at four annual sampling points. HCC was determined in the first 1...
May 2, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775874/emotion-regulation-as-a-predictor-of-the-endocrine-autonomic-affective-and-symptomatic-stress-response-and-recovery
#16
Katarina Krkovic, Annika Clamor, Tania M Lincoln
Stress is associated with the development of mental disorders such as depression and psychosis. The ability to regulate emotions is likely to influence how individuals respond to and recover from acute stress, and may thus be relevant to symptom development. To test this, we investigated whether self-reported emotion regulation predicts the endocrine, autonomic, affective, and symptomatic response to and recovery from a stressor. Social-evaluative stress was induced by the Trier Social Stress Test (TSST) in N = 67 healthy individuals (53...
April 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29754004/natural-disaster-related-prenatal-maternal-stress-is-associated-with-alterations-in-placental-glucocorticoid-system-the-qf2011-queensland-flood-study
#17
Joey St-Pierre, David P Laplante, Guillaume Elgbeili, Paul A Dawson, Sue Kildea, Suzanne King, Cathy Vaillancourt
We investigated the effects of a natural disaster (a sudden flood) as a source of prenatal maternal stress (PNMS) on the placental glucocorticoid system and glucose transporters. Whether the gestational age at the time of the flood moderated these effects was also evaluated. Placental samples were collected from participants in the 2011 Queensland Flood Study (QF2011) who were pregnant in the first or second trimester at the onset of the flood. Detailed questionnaire results for objective hardship and composite subjective distress were obtained to assess stress levels...
April 26, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29727809/oxytocin-strengthens-the-link-between-provocation-and-aggression-among-low-anxiety-people
#18
Michaela Pfundmair, Annika Reinelt, C Nathan DeWall, Lisa Feldmann
Oxytocin (OT) not only modulates positive social interactions but also affects negative ones. Several studies have established a link between OT and aggression. However, they also resulted in an inconsistent picture and showed methodological issues. The current studies aimed to address these lacks and test the hypothesis that OT increases provocation-induced aggression in people low in anxiety. Therefore, two studies with 56 males (Study 1) as well as 40 females and 24 males (Study 2) were conducted. After responding to a trait anxiety questionnaire, participants self-administered OT or a placebo...
April 26, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29715652/longitudinal-associations-between-biomarkers-of-inflammation-and-changes-in-depressive-symptoms-in-diabetic-patients
#19
LETTER
Marijana Vučić Lovrenčić, Mirjana Pibernik Okanović
No abstract text is available yet for this article.
April 25, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29754005/the-effect-of-gestational-period-on-the-association-between-maternal-prenatal-salivary-cortisol-and-birth-weight-a-systematic-review-and-meta-analysis
#20
REVIEW
Stephana J Cherak, Gerald F Giesbrecht, Amy Metcalfe, Paul E Ronksley, Mary E Malebranche
BACKGROUND: Studies exploring the relations between maternal stress and fetal development show an association between increased maternal stress and adverse birth outcomes. A frequently proposed mechanism linking maternal prenatal stress and adverse birth outcomes is heightened concentrations of maternal cortisol. To date, studies exploring this association have reported conflicting results because of the diverse approaches taken to measuring cortisol and the wide variety of possible birth outcomes explored...
April 24, 2018: Psychoneuroendocrinology
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