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Psychoneuroendocrinology

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https://www.readbyqxmd.com/read/29433760/corrigendum-to-pup-exposure-facilitates-retrieving-behavior-via-the-oxytocin-neural-system-in-female-mice-psychoneuroendocrinology-79-2017-20-30
#1
Shota Okabe, Yosuke Tsuneoka, Aki Takahashi, Rumi Oyama, Akiyuki Watarai, Sayaka Maeda, Yuka Honda, Miho Nagasawa, Kazutaka Mogi, Katsuhiko Nishimori, Masaru Kuroda, Tsuyoshi Koide, Takefumi Kikusui
No abstract text is available yet for this article.
February 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29433072/pregnenolone-progesterone-allopregnanolone-pathway-as-a-potential-therapeutic-target-in-first-episode-antipsychotic-na%C3%A3-ve-patients-with-schizophrenia
#2
HuaLin Cai, Xiang Zhou, George G Dougherty, Ravinder D Reddy, Gretchen L Haas, Debra M Montrose, Matcheri Keshavan, Jeffrey K Yao
Neurosteroids are both endogenous and exogenous steroids that rapidly alter neuronal excitability through interactions with ligand-gated ion channels and other cell surface receptors. They are originated from cholesterol and have important implications for schizophrenia (SZ) pathophysiology and treatment strategies. Specifically, pregnenolone (PREG), progesterone (PROG) and allopregnanolone (ALLO) exhibit similar psychotropic properties. Using enzyme immunoassay, we compared the neurosteroids in PREG downstream pathways in plasma between healthy controls (HC, n = 43) and first-episode antipsychotic-naïve patients with SZ (FEAN-SZ, n = 53) before antipsychotic drug (APD) treatment...
February 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29433073/link-between-children-s-hair-cortisol-and-psychopathology-or-quality-of-life-moderated-by-childhood-adversity-risk
#3
Anna Fuchs, Charlotte Jaite, Corinne Neukel, Katja Dittrich, Katja Bertsch, Dorothea Kluczniok, Eva Möhler, Catherine Hindi Attar, Romuald Brunner, Katja Bödeker, Franz Resch, Felix Bermpohl, Michael Kaess
The hypothalamus-pituitary-adrenal axis (HPAA) and its end product, the glucocorticoid cortisol, has been shown to be associated with psychopathology. Determining cortisol concentrations in hair (HCC) allows the investigation of long-term HPAA-activity. There is a significant scarcity of studies investigating the link between HCC and psychopathology and quality of life in child and adolescent samples. In addition, as the HPAA constitutes a feedback system enabling adaption to environmental demands, it is important to consider the socio-environmental context that the children grow up in...
February 6, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29427955/allostatic-load-is-associated-with-psychotic-symptoms-and-decreases-with-antipsychotic-treatment-in-patients-with-schizophrenia-and-first-episode-psychosis
#4
Maximus Berger, Robert-Paul Juster, Sabine Westphal, G Paul Amminger, Bernhard Bogerts, Kolja Schiltz, Sabine Bahn, Johann Steiner, Zoltan Sarnyai
Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics...
February 5, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29433074/the-relationship-between-inflammatory-state-and-quantity-of-affective-episodes-in-bipolar-disorder
#5
Robert Queissner, René Pilz, Nina Dalkner, Armin Birner, Susanne A Bengesser, Martina Platzer, Frederike T Fellendorf, Nora Kainzbauer, Simone Herzog-Eberhard, Carlo Hamm, Bernd Reininghaus, Sieglinde Zelzer, Harald Mangge, Rodrigo B Mansur, Roger S McIntyre, Hans-Peter Kapfhammer, Eva Z Reininghaus
OBJECTIVES: Immunological/inflammatory processes have been proposed to play an important role in the pathophysiology of mood disorders, including bipolar disorder (BD). The present study aimed to examine the influence of immune activation, measured on the basis of inflammatory markers, on the course of illness, proxied by the number of affective episodes, in patients with BD. METHODS: We investigated the relationship between high-sensitive CRP (hsCRP) and Interleukin 6 (IL-6), two inflammatory markers and characteristics of course of illness (e...
February 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414033/associations-of-inflammation-with-symptom-burden-in-patients-with-acute-myeloid-leukemia
#6
Tamara E Lacourt, Annemieke Kavelaars, Jessica R Galloway-Peña, Pranoti V Sahasrabhojane, Nina D Shah, Andrew Futreal, Dimitrios P Kontoyiannis, Samuel A Shelburne, Cobi J Heijnen
The aim of the study was to assess the association inflammation with symptom burden in patients with acute myeloid leukemia (AML), assessed before and during remission induction chemotherapy (IC). Patients with AML (n = 95) were followed from baseline (before IC) to the third week of IC for severity of self-reported somatic symptoms (assessed with the MD Anderson Symptom Inventory) and plasma levels of 13 inflammation-related biomarkers (n = 64). A composite symptom burden severity score was computed as the average score of the six most severe somatic symptoms i...
February 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29449045/how-to-measure-glucocorticoid-receptor-s-sensitivity-in-patients-with-stress-related-psychiatric-disorders
#7
REVIEW
Carolin Leistner, Andreas Menke
Stress is a state of derailed homeostasis and a main environmental risk factor for psychiatric diseases. Chronic or uncontrollable stress may lead to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is a common feature of stress-related psychiatric disorders. One of the key mechanisms underlying a disturbed HPA axis is an impaired function of the glucocorticoid receptor (GR) with an enhanced or reduced feedback sensitivity for glucocorticoids and subsequently altered concentrations of peripheral cortisol...
February 2, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29433075/glucocorticoid-receptor-gene-methylation-moderates-the-association-of-childhood-trauma-and-cortisol-stress-reactivity
#8
Nina Alexander, Clemens Kirschbaum, Matthis Wankerl, Benjamin J Stauch, Tobias Stalder, Susann Steudte-Schmiedgen, Markus Muehlhan, Robert Miller
Exposure to childhood trauma (CT) has been linked to sustained dysregulations of major stress response systems, including findings of both exaggerated and attenuated hypothalamus-pituitary-adrenal (HPA) axis activity. Likewise, CT constitutes a common risk factor for a broad range of psychiatric conditions that involve distinct neuroendocrine profiles. In this study, we investigated the role of epigenetic variability in a stress-related gene as a potential mediator or moderator of such differential trajectories in CT survivors...
January 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29425788/trait-mindfulness-predicts-the-presence-but-not-the-magnitude-of-cortisol-responses-to-acute-stress
#9
Andrew W Manigault, Alex Woody, Peggy M Zoccola, Sally S Dickerson
BACKGROUND: Mindfulness, or the practice of observing present moment experiences with acceptance, is thought to improve health at least partially by limiting hypothalamic-pituitary-adrenal (HPA) axis over-responsiveness during episodes of acute stress. However, models of allostatic load suggest that HPA axis under-responsiveness can also be detrimental to health, and the relationship between mindfulness and cortisol under-responsiveness has yet to be examined. The present study therefore aimed to address this knowledge gap, and to revisit the relationship between mindfulness and acute cortisol response magnitude while excluding (or statistically controlling for) individuals displaying HPA axis under-responsiveness...
January 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29407513/dissociable-roles-of-glucocorticoid-and-noradrenergic-activation-on-social-discounting
#10
Zsofia Margittai, Marijn van Wingerden, Alfons Schnitzler, Marian Joëls, Tobias Kalenscher
People often exhibit prosocial tendencies towards close kin and friends, but generosity decreases as a function of increasing social distance between donor and recipient, a phenomenon called social discounting. Evidence suggests that acute stress affects prosocial behaviour in general and social discounting in particular. We tested the causal role of the important stress neuromodulators cortisol (CORT) and noradrenaline (NA) in this effect by considering two competing hypotheses. On the one hand, it is possible that CORT and NA act in concert to increase generosity towards socially close others by reducing the aversiveness of the cost component in costly altruism and enhancing the emotional salience of vicarious reward...
January 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414034/stress-induced-cortisol-release-and-schizotypy
#11
Emma E Walter, Francesca Fernandez, Mollie Snelling, Emma Barkus
Cortisol is involved in preparing the body's response for stress. However, in those at risk for mental health problems, abnormal cortisol release following stress has been reported. In particular, we are yet to fully understand how stress leads to an exacerbation of symptoms and progression of risk in those who express psychosis proneness or schizotypy. Using the Trier Social Stress Test, we examined the effect of experimentally induced psychosocial stress on cortisol release in otherwise healthy individuals with schizotypal traits...
January 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414032/functional-tspo-polymorphism-predicts-variance-in-the-diurnal-cortisol-rhythm-in-bipolar-disorder
#12
Alan R Prossin, Matthew Chandler, Kelly A Ryan, Erika F Saunders, Masoud Kamali, Vassilios Papadopoulos, Sebastian Zöllner, Robert Dantzer, Melvin G McInnis
INTRODUCTION: Psychosocial stress contributes to onset/exacerbation of mood episodes and alcohol use, suggesting dysregulated diurnal cortisol rhythms underlie episodic exacerbations in Bipolar Disorder (BD). However, mechanisms underlying dysregulated HPA rhythms in BD and alcohol use disorders (AUD) are understudied. Knowledge of associated variance factors have great clinical translational potential by facilitating development of strategies to reduce stress-related relapse in BD and AUD...
January 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29407514/prenatal-stress-and-genetic-risk-how-prenatal-stress-interacts-with-genetics-to-alter-risk-for-psychiatric-illness
#13
REVIEW
Parker W Abbott, Serena B Gumusoglu, Jada Bittle, David Q Beversdorf, Hanna E Stevens
Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic endowment and their environmental experiences and exposures. Embryonic development captures a particularly complex period, in which genetic and environmental factors can interact to contribute to risk. These environmental factors are incorporated differently into the embryonic brain than postnatal one. Here, we comprehensively review the human and animal model literature for studies that assess the interaction between genetic risks and one particular environmental exposure with strong and complex associations with neuropsychiatric outcomes-prenatal maternal stress...
January 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29395487/co-variation-of-fatigue-and-psychobiological-stress-in-couples-everyday-life
#14
Johanna M Doerr, Urs M Nater, Ulrike Ehlert, Beate Ditzen
OBJECTIVE: There is limited knowledge about how fatigue develops and worsens and what influences fluctuations in daily fatigue. Stress was found to influence fatigue, and being in a relationship seems to either increase or decrease stress depending on the couple interaction. In this study, co-variation of fatigue, self-reported stress, and biological stress markers in couples' everyday lives was investigated. Specifically, we examined a) whether momentary couple interactions moderated dyadic outcomes and b) whether and how stress and relationship measures influenced individual momentary fatigue...
January 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414031/unfolded-protein-response-and-associated-alterations-in-toll-like-receptor-expression-and-interaction-in-the-hippocampus-of-restraint-rats
#15
Matthew Timberlake, Kevin Prall, Bhaskar Roy, Yogesh Dwivedi
Recent evidence suggests that the cellular response to stress often elicits the unfolded protein response (UPR), which has an active role in major depression in emotionally relevant regions of the brain, such as the hippocampus. Much of the UPR activity has been found to be coalesced with the pro-inflammatory environment of the depressed brain. Specifically, downstream transcriptions of pro-inflammatory cytokines and increased regulation of candidate inflammatory mediators, such as toll-like receptors (TLRs), are promoted by the UPR...
January 26, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414030/effects-of-blood-glucose-on-delay-discounting-food-intake-and-counterregulation-in-lean-and-obese-men
#16
Johanna Klement, Britta Kubera, Jonas Eggeling, Christin Rädel, Christin Wagner, Soyoung Q Park, Achim Peters
BACKGROUND: Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay discounting yielded mixed results. We hypothesized that obese people - in comparison to lean men - have a relative lack of energy, especially when blood glucose levels are low, that results in higher levels of delay discounting, food intake and hormonal counterregulation...
January 23, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29396320/pain-exposure-associates-with-telomere-length-erosion-in-very-preterm-infants
#17
Livio Provenzi, Roberto Giorda, Monica Fumagalli, Uberto Pozzoli, Francesco Morandi, Giunia Scotto di Minico, Fabio Mosca, Renato Borgatti, Rosario Montirosso
Very preterm (VPT) infants (gestational age < 32 weeks) require long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), even in absence of severe morbidities. During NICU stay, life-saving interventions occur and include invasive and painful skin-breaking procedures (NICU-related stress), which constitute a major early adverse experience for VPT infants. Telomeres are repeat-sequence at the end of chromosomes, which shorten with age and are highly susceptible to life adversities: the exposure to early adverse experiences is associated with shorter telomere length (TL)...
January 20, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414027/associations-of-work-stress-with-hair-cortisol-concentrations-initial-findings-from-a-prospective-study
#18
Raphael M Herr, Christian Almer, Adrian Loerbroks, Amira Barrech, Irina Elfantel, Johannes Siegrist, Harald Gündel, Peter Angerer, Jian Li
There is ample evidence supporting the link between stress at the workplace and physical and mental health. One of the pathways potentially mediating those associations may involve the hypothalamic-pituitary-adrenal (HPA) axis, with cortisol as an end product. While theoretically plausible, findings on the association of self-reported work stress with hair cortisol concentrations (HCC) are inconclusive, being potentially biased by omitted pertinent factors. This issue can be addressed, among others, by eliminating time-invariant factors through consideration of variation within persons over time...
January 18, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29414029/control-of-cardiovascular-responses-to-stress-by-crf-in-the-bed-nucleus-of-stria-terminalis-is-mediated-by-local-nmda-nnos-sgc-pkg-signaling
#19
Leandro A Oliveira, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The aims of the present study were to assess an interaction of corticotropin-releasing factor (CRF) neurotransmission within the bed nucleus of the stria terminalis (BNST) with local nitrergic signaling, as well as to investigate an involvement of activation of local NMDA glutamate receptor and nitric oxide (NO) signaling in control of cardiovascular responses to acute restraint stress by BNST CRF neurotransmission in rats. We observed that CRF microinjection into the BNST increased local NO release during restraint stress...
January 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29358119/low-subjective-socioeconomic-status-stimulates-orexigenic-hormone-ghrelin-a-randomised-trial
#20
A Y Sim, E X Lim, M K Leow, B K Cheon
Recent evidence suggests that lower perceived socioeconomic status is linked to increased appetite and intake of greater calories. Yet, whether insecurity of socioeconomic resources directly influences regulatory systems of appetite and energy intake is not known. Considering psychological states, mindsets and beliefs have shown to meaningfully affect physiological responses to food, the present study tested the hypothesis that low subjective socioeconomic status (SSS) will have a direct influence on physiological responses, such as appetite-related hormones (ghrelin, pancreatic polypeptide and insulin)...
January 12, 2018: Psychoneuroendocrinology
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