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E R Landau, J Trinder, J G Simmons, M Raniti, M Blake, J M Waloszek, L Blake, O Schwartz, G Murray, N B Allen, M L Byrne
Inflammatory markers including C-Reactive Protein (CRP) are increasingly used within research and clinical settings. Yet, varying methodologies for cleaning immunoassay data with out of range (OOR) samples may alter characteristic levels of CRP, thereby obscuring interpretation and reliability. This study investigated the influence of eight immunoassay OOR data treatment techniques on salivary CRP (sCRP) samples from at-risk adolescents. Participants from the 'Sleep and Education: learning New Skills Early' (SENSE) Study were 86 adolescents at-risk for depression (50 female), aged 14...
September 8, 2018: Psychoneuroendocrinology
N M Molenaar, H Tiemeier, E F C van Rossum, M H J Hillegers, C L H Bockting, W J G Hoogendijk, E L van den Akker, M P Lambregtse-van den Berg, H El Marroun
OBJECTIVE: Intrauterine exposures such as maternal psychopathology and stress are known to influence the physical and mental health of the offspring. One of the proposed pathways underlying these associations is dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity in the offspring. This study examined the relation of perinatal maternal symptoms of psychopathology and stress with offspring HPA axis activity at 6 years as measured by hair cortisol and cortisone concentrations...
September 7, 2018: Psychoneuroendocrinology
Jonas Hornung, Hannes Noack, Lydia Kogler, Birgit Derntl
The dot probe task implicitly cues attention via emotional information, an effect which is especially pronounced for threat-related cues. However, several questions remain unexplored. The first one is whether chemosignals like the androgen-derivative androstadienone can influence such attentional biases. Second, few studies have addressed sex differences regarding attentional biases. Finally, the neural correlates of these potential behavioral effects based on functional magnetic resonance imaging (fMRI) are not known...
September 6, 2018: Psychoneuroendocrinology
Patrick Quinlan, Alexandra Horvath, Anders Wallin, Johan Svensson
BACKGROUND: In epidemiological studies, thyroid hormones (THs) have been associated with the risk of dementia. However, little is known of the relation between THs and risk of Alzheimer's disease (AD) or vascular dementia (VaD) in a memory clinic population. METHODS: In a mono-center study, serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were assessed in 302 patients. All patients had subjective or objective mild cognitive impairment and none received treatment with THs...
September 5, 2018: Psychoneuroendocrinology
Allison M Perkeybile, C Sue Carter, Kelly L Wroblewski, Meghan H Puglia, William M Kenkel, Travis S Lillard, Themistoclis Karaoli, Simon G Gregory, Niaz Mohammadi, Larissa Epstein, Karen L Bales, Jessica J Connelly
Mammalian sociality is regulated in part by the neuropeptide oxytocin. In prairie voles, subtle variation in early life experience changes oxytocin receptor-mediated social behaviors. We report that low levels of early care in voles leads to de novo DNA methylation at specific regulatory sites in the oxytocin receptor gene (Oxtr), impacting gene expression and protein distribution in the nucleus accumbens. DNA methylation state of the blood predicts expression in the brain indicating the utility of the blood as a biomarker for the transcription state of the brain...
August 31, 2018: Psychoneuroendocrinology
Lauren M Osborne, Gayane Yenokyan, Kezhen Fei, Thomas Kraus, Thomas Moran, Catherine Monk, Rhoda Sperling
BACKGROUND: There are complex associations between immune function and mental illness, yet studies in the perinatal period focus primarily on individual inflammatory markers and depressive symptoms only, cross-sectionally. We sought to examine associations between both depressive and anxious symptoms and immune activation longitudinally across the peripartum. METHODS: We measured mood (Beck Depression Inventory, BDI-1 A) and anxiety (State-Trait Anxiety Inventory, STATE) and levels of 23 cytokines at 5 points in pregnancy and postpartum in 51 women...
August 31, 2018: Psychoneuroendocrinology
Cristina Siller-Pérez, Antonio Fuentes-Ibañez, Erika L Sotelo-Barrera, Norma Serafín, Roberto A Prado-Alcalá, Patrizia Campolongo, Benno Roozendaal, Gina L Quirarte
The endocannabinoid (eCB) system is highly stress sensitive and known to modulate memory formation of emotionally arousing experiences across different corticolimbic structures. eCB signaling within these circuits is also essentially involved in regulating non-genomically mediated glucocorticoid hormone effects on memory. It has long been thought that the dorsal striatum, which plays a major role in procedural memory and habit formation, is considerably less impacted by stressful experiences; however, recent findings indicate that stress and glucocorticoids also affect striatal-dependent memory processes...
August 30, 2018: Psychoneuroendocrinology
Mohsen Ayrout, Florian Le Billan, Valérie Grange-Messent, Sakina Mhaouty-Kodja, Marc Lombès, Stéphanie Chauvin
Stress-induced reproductive dysfunction is frequently associated with increased glucocorticoid (GC) levels responsible for suppressed GnRH/LH secretion and impaired ovulation. Besides the major role of the hypothalamic kisspeptin system, other key regulators may be involved in such regulatory mechanisms. Herein, we identify dynorphin as a novel transcriptional target of GC. We demonstrate that only priming with high estrogen (E2) concentrations prevailing during the late prooestrus phase enables stress-like GC concentrations to specifically stimulate Pdyn (prodynorphin) expression both in vitro (GT1-7 mouse hypothalamic cell line) and ex vivo (ovariectomized E2-supplemented mouse brains)...
August 29, 2018: Psychoneuroendocrinology
Marion Schwaiger, Markus Heinrichs, Robert Kumsta
Adverse childhood experience such as neglect or abuse can lead to long-term deficits in emotion processing abilities. Animal studies indicate that oxytocin production and/or sensitivity are influenced by variation in early nurturing experiences. The goal of this study was to test whether emotion recognition abilities and empathy might be improved via intranasal oxytocin administration in adults with a history of childhood maltreatment. We assessed a total of 80 healthy participants, half with and half without a history of childhood adversity...
August 27, 2018: Psychoneuroendocrinology
Thiago Wendt Viola, Luis Eduardo Wearick-Silva, Kerstin C Creutzberg, Érika Kestering-Ferreira, Rodrigo Orso, Anderson Centeno-Silva, Lucas Albrechet-Souza, Paul R Marshall, Xiang Li, Timothy W Bredy, Marco A Riva, Rodrigo Grassi-Oliveira
While increasing evidence posits poor decision-making as a central feature of mental disorders, very few studies investigated the effects of early-life stress (ELS) on specific components of reward-related choice behaviors. Risk-taking (RT) involves the exposure to some danger, or negative consequences, in order to achieve a goal-directed behavior. Such behaviors are likely to be preceded by risk-assessment (RA), which is a dynamic cognitive process involving the acquisition of information in potentially dangerous situations...
August 26, 2018: Psychoneuroendocrinology
Bernadette von Dawans, Beate Ditzen, Amalie Trueg, Urs Fischbacher, Markus Heinrichs
Acute stress is known to increase prosocial behavior in men via a "tend-and-befriend" pattern originally proposed as a specifically female stress response alongside the fight-or-flight response. However, the direct effects of acute stress on women's social behavior have not been investigated. Applying the Trier Social Stress Test for groups (TSST-G), 94 women were confronted with either a stress or control condition. We repeatedly measured their subjective stress responses, salivary cortisol, and heart rate, and investigated their level of trust, trustworthiness, sharing, punishment and non-social risk using social decision paradigms...
August 25, 2018: Psychoneuroendocrinology
Martin Griebe, Anne Ebert, Frauke Nees, Katharina Katic, Benjamin Gerber, Kristina Szabo
INTRODUCTION: Stress-related transient inhibition of memory formation in the hippocampus has been hypothesized as one of the underlying pathomechanisms of transient global amnesia (TGA). TGA episodes, during which patients cannot encode and recall new information (anterograde amnesia affecting episodic long-term memory), are frequently preceded by a psychologically or physically stressful event. METHODS: We measured salivary cortisol during acute TGA in 14 patients, as well as cortisol day-profiles and the effect of experimental exposure to stress (using the socially evaluated cold pressor test) on cortisol levels during the subacute phase...
August 25, 2018: Psychoneuroendocrinology
Allison M Garrison, Jennifer M Parrott, Arnulfo Tunon, Jennifer Delgado, Laney Redus, Jason C O'Connor
No abstract text is available yet for this article.
August 24, 2018: Psychoneuroendocrinology
Corinna Hartling, Yan Fan, Anne Weigand, Irene Trilla, Matti Gärtner, Malek Bajbouj, Isabel Dziobek, Simone Grimm
BACKGROUND: Early life stress (ELS) affects facial emotion recognition (FER), as well as the underlying brain network. However, there is considerable inter-individual variability in these ELS-caused alterations. As the hypothalamic-pituitary-adrenal (HPA) axis is assumed to mediate neural and behavioural sequelae of ELS, the genetic disposition towards HPA axis reactivity might explain differential vulnerabilities. METHODS: An additive genetic profile score (GPS) of HPA axis reactivity was built from 6 SNPs in 3 HPA axis-related genes (FKBP5, CRHR1, NR3C1)...
August 24, 2018: Psychoneuroendocrinology
M P Rozing, R Veerhuis, R G J Westendorp, P Eikelenboom, M Stek, R M Marijnissen, R C Oude Voshaar, H C Comijs, E van Exel
OBJECTIVE: Different biological mechanisms may underlie depression beginning in early life (early-onset) and depression beginning later in life (late-onset). Although the relation between inflammation and depression has been studied extensively, the distinct role of inflammation in early and late-onset depression in older patients has not been addressed before. In the cross-sectional part of this study, we explored differences in levels of circulating inflammatory markers and cytokine levels in lipopolysaccharide (LPS) stimulated whole blood between older subjects with a late-life onset depression (≥60 years) and older subjects with an early-onset depression (<60 years)...
August 24, 2018: Psychoneuroendocrinology
João C P Santiago, Hong-Viet Ngo, Carola Jickeli, Andreas Peter, Manfred Hallschmid
Impaired sleep quality and sleep loss compromise glucose homeostasis and metabolic function, but the mechanisms linking sleep and metabolic health are largely unclear. In order to gain insight into the relevance of specific electrophysiological sleep characteristics for metabolic control, we assessed the acute effect on glucose homeostasis as well as energy intake and expenditure of enhancing slow oscillatory activity, a hallmark of slow-wave sleep, by closed-loop auditory stimulation in healthy men. Twenty-two young, normal-weight men underwent an oral glucose tolerance test (oGTT), indirect calorimetry and the assessment of ad-libitum breakfast intake in the morning after nocturnal sleep with or without auditory stimulation in phase with the ongoing rhythmic occurrence of slow oscillation up-states during 210 min of slow-wave sleep in the first night-half...
August 23, 2018: Psychoneuroendocrinology
Ragnhild Sørensen Høifødt, Knut Waterloo, Catharina E A Wang, Martin Eisemann, Yngve Figenschau, Marianne Halvorsen
The association between depressive symptoms and elevated cortisol levels, and depression and cognitive functioning, has been less robust in outpatients with symptoms in the mild to moderate range. Furthermore, the association between elevated cortisol levels and cognitive functioning is unclear. In the present study, currently depressed (n = 37), previously depressed (n = 81) and never depressed controls (n = 50) were assessed on a range of neuropsychological measures. Salivary cortisol was measured in the morning and evening...
August 22, 2018: Psychoneuroendocrinology
Natalie Slopen, Andrea L Roberts, Kaja Z LeWinn, Nicole R Bush, Cynthia R Rovnaghi, Frances Tylavsky, Kanwaljeet J S Anand
BACKGROUND AND OBJECTIVE: Maternal trauma can have intergenerational consequences but little is known about whether maternal traumas affect key biological domains associated with mental health in their offspring. The objective of this study was to examine maternal lifetime history of traumatic events through mid-gestation in relation to offspring cortisol production in early childhood. METHODS: The sample was comprised of 660 children (49.9% Black, 44.4% White) from a longitudinal study of mother-offspring dyads in Shelby County, Tennessee, followed from mid-gestation to child age 4 years (enrolled 2006-2011)...
August 22, 2018: Psychoneuroendocrinology
Wai S Tse, Angela F Y Siu, Qian Zhang, H Y Edwin Chan
BACKGROUND: Oxytocin is related to positive parenting behaviours and social cognition. Long-term relationships are partly influenced by the social memory of a person. Positive social memory with the attachment figure may play a mediating role between oxytocin responsiveness and positive parenting behaviours. METHODOLOGY: The study recruited 61 pairs of married mothers and preschool children from a community in Hong Kong. Sociodemographic background and neuroticism data of the respondents were collected in a laboratory...
August 19, 2018: Psychoneuroendocrinology
Dongju Seo, Arielle G Rabinowitz, Ryan J Douglas, Rajita Sinha
Trauma alters neuroendocrine responses to stress and increases vulnerability to stress-related disorders. Yet, relationships among trauma, stress-induced neural changes and hypothalamic-pituitary-adrenal (HPA) axis activity have not been determined. The present study used functional magnetic resonance imaging to investigate the impact of life trauma on basal cortisol levels and neural responses to acute stress in 73 healthy individuals during brief stress and neutral-relaxing imagery using a well-established, individualized imagery method...
August 17, 2018: Psychoneuroendocrinology
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