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Psychoneuroendocrinology

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https://www.readbyqxmd.com/read/29241148/obesity-exacerbates-the-acute-metabolic-side-effects-of-olanzapine
#1
Logan K Townsend, Willem T Peppler, Natasha D Bush, David C Wright
Olanzapine is a second-generation antipsychotic used in the management of schizophrenia and various off-label conditions. The acute metabolic responses of olanzapine recapitulate many of the side effects associated with obesity. Obesity rates are high in the schizophrenic population, but it is unknown whether pre-existing obesity-associated metabolic dysfunction augments the acute side effects of olanzapine. To address this question, we compared the responses to olanzapine in lean and high-fat diet-induced (HFD) obese mice...
December 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29223002/basal-and-reactivity-levels-of-cortisol-in-one-month-old-infants-born-to-overweight-or-obese-mothers-from-an-ethnically-and-racially-diverse-low-income-community-sample
#2
Karen M Jones-Mason, Michael Coccia, Stephanie Grover, Elissa Epel, Nicole R Bush
Establishing typical values of the steroid hormone cortisol at rest and after challenge is critical for understanding how environmental factors impact stress regulation and overall development, beginning at birth. Yet most extant samples are small or based upon low-risk populations, and few studies address the potential role of maternal weight during pregnancy in their study designs or sampling strategy. Here we report basal and reactivity levels of salivary cortisol within a racially and ethnically diverse sample of 132 infants approximately one month of age (Age in days: M=37...
December 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29203078/response-to-arteaga-et-al
#3
LETTER
Kiyuri Naicker, Simon Øverland, Ian Colman
No abstract text is available yet for this article.
December 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29197795/reproductive-steroids-and-adhd-symptoms-across-the-menstrual-cycle
#4
Bethan Roberts, Tory Eisenlohr-Moul, Michelle M Martel
Although Attention-Deficit/Hyperactivity Disorder shows (ADHD) male predominance, females are significantly impaired and exhibit additional comorbid disorders during adolescence. However, no empirical work has examined the influence of cyclical fluctuating steroids on ADHD symptoms in women. The present study examined estradiol (E2), progesterone (P4), and testosterone (T) associations with ADHD symptoms across the menstrual cycle in regularly-cycling young women (N=32), examining trait impulsivity as a moderator...
November 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29197794/there-is-an-association-between-serum-high-sensitivity-c-reactive-protein-hs-crp-concentrations-and-depression-score-in-adolescent-girls
#5
Seyed-Amir Tabatabaeizadeh, Mojtaba Fattahi Abdizadeh, Zahra Meshkat, Ezzat Khodashenas, Susan Darroudi, Mostafa Fazeli, Gordon A Ferns, Amir Avan, Majid Ghayour-Mobarhan
BACKGROUND: Whilst there is evidence of an association between depression and inflammation in adults, there is limited data on this in adolescents particularly in non-westernized populations. ‎ The primary aim of this study was to evaluate the association between serum hs-CRP level and depression ‎score in adolescent girls living in northwestern Iran. METHOD: Serum hs-CRP was measured in 563 adolescent girls aged 12-18 years. Depression score was assessed using the Beck's depression inventory II (BDI-II)...
November 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29195162/effects-of-adolescent-social-stress-and-antidepressant-treatment-on-cognitive-inflexibility-and-bdnf-epigenetic-modifications-in-the-mpfc-of-adult-mice
#6
Hang Xu, Jiesi Wang, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao, Weiwen Wang
Adolescent social stress (ASS) can increase susceptibility to depression in adulthood. However, the underlying psychological and neural mechanisms remain unclear. Cortically mediated cognitive dysfunctions are increasingly recognized as an independent and important risk factor of depression. Using social defeat stress, a classical animal model of depression, our previous studies found that mice subjected to this form of stress during early adolescence displayed cognitive inflexibility (CI) in adulthood. This change was accompanied by a down-regulation of Bdnf gene expression in the medial prefrontal cortex (mPFC); this gene encodes a key molecule involved in depression and antidepressant action...
November 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29175720/t4-and-waist-hip-ratio-as-biomarkers-of-antipsychotic-induced-weight-gain-in-han-chinese-inpatients-with-schizophrenia
#7
Shen Li, Ying Gao, Hao Lv, Miaomiao Zhang, Lili Wang, Rui Jiang, Chengai Xu, Xueshi Wang, Ming Gao, Yukun He, Jie Li, Wei-Dong Li
Second-generation antipsychotic agents (SGAs) cause serious metabolic side effects, including weight gain, dyslipidemia, and glucose metabolism abnormalities, which occur by unknown mechanisms. Therefore, the search for prospective markers for antipsychotic-induced weight gain (AIWG) has been of major interest. So far, predictive factors predisposing patients to the develop obesity and related metabolic disturbances induced by SGAs have been relatively less studied among large samples of Chinese schizophrenic patients...
November 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29161636/infant-hpa-axis-as-a-potential-mechanism-linking-maternal-mental-health-and-infant-telomere-length
#8
Benjamin W Nelson, Nicholas B Allen, Heidemarie Laurent
Maternal depression has been suggested to be an independent risk factor for both dysregulated hypothalamic-pituitary-adrenal axis (HPA) functioning and shorter telomere length in offspring. In contrast, research suggests that individual differences in mindfulness may act as a protective factor against one's own telomere degradation. Currently, research has yet to investigate the association between longitudinal changes in maternal mental health (depressive symptoms and mindfulness) and salivary infant telomere length, and whether such changes might be mediated by alterations in infant cortisol response...
November 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29175736/brain-structural-connectivity-during-adrenarche-associations-between-hormone-levels-and-white-matter-microstructure
#9
Marjolein E A Barendse, Julian G Simmons, Michelle L Byrne, Marc L Seal, George Patton, Lisa Mundy, Stephen J Wood, Craig A Olsson, Nicholas B Allen, Sarah Whittle
Levels of the adrenal hormones dehydroepiandrosterone (DHEA), its sulfate (DHEAS), and testosterone, have all been linked to behavior and mental health during adrenarche, and preclinical studies suggest that these hormones influence brain development. However, little is known about how variation in these hormones is associated with white matter structure during this period of life. The current study aimed to examine associations between DHEA, DHEAS, and testosterone, and white matter microstructure during adrenarche...
November 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29175721/de-masking-oxytocin-deficiency-in-craniopharyngioma-and-assessing-its-link-with-affective-function
#10
Dorothea Gebert, Matthias K Auer, Mareike R Stieg, Martin T Freitag, Madlén Lahne, Johannes Fuss, Katharina Schilbach, Jochen Schopohl, Günter K Stalla, Anna Kopczak
Despite the high prevalence of panhypopituitarism and diabetes insipidus in patients with craniopharyngioma (CP), little is known about the functioning of the neuropeptide oxytocin in these patients. This is of special interest as tumor-associated lesions often impair sites critical for oxytocin production and release, and affective dysfunction in CP links with elsewhere reported prosocial, antidepressant and anxiolytic oxytocin effects. Using a prospective study-design, we tested whether oxytocin is reduced in CP-patients, and whether altered oxytocin levels account for affective and emotional dysfunction...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29161637/la-donna-%C3%A3-mobile-lack-of-cyclical-shifts-in-facial-symmetry-and-facial-and-body-masculinity-preferences-a-hormone-based-study
#11
Urszula M Marcinkowska, Andrzej Galbarczyk, Grazyna Jasienska
Although under investigation for more than two decades, a common agreement on the occurrence of cyclical shifts in women's masculinity and symmetry preferences is still missing. Such shifts are considered to be an important feature of sexual selection as they supposedly direct women's attention towards cues for "good genes" (e.g. masculinity and symmetry) during times when probability of conception is the highest. Multiple studies have, however, failed to find these shifts. We attempt to address this lack of agreement analysing a sample of 110 healthy women, using intra-participant design and repeated measurements of oestradiol and LH during the cycle...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29156403/the-role-of-trauma-in-the-hormonal-interplay-of-cortisol-testosterone-and-oxytocin-in-adolescent-aggression
#12
REVIEW
Iro Fragkaki, Maaike Cima, Isabela Granic
Although numerous studies have examined the neuroendocrinology of aggression, the findings are mixed and focused on cortisol and testosterone. We argue that past findings remain inconclusive partly because the key roles of oxytocin and trauma have not been systematically integrated yet. Oxytocin is associated with social behavior and interacts with cortisol and testosterone, whereas trauma is a crucial risk factor of aggression that strongly affects hormonal activity. In this review, we investigate the role of trauma in the hormonal interplay of cortisol, testosterone, and oxytocin in aggression during adolescence...
November 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29144990/effects-of-childhood-trauma-on-cortisol-levels-in-suicide-attempters-and-ideators
#13
Daryl B O'Connor, Jessica A Green, Eamonn Ferguson, Ronan E O'Carroll, Rory C O'Connor
OBJECTIVES: Suicide is a global health issue. Dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, has been identified as one potential risk factor for suicide. Recent evidence has indicated that blunted cortisol reactivity to stress is associated with suicidal behavior. The current study investigated whether childhood trauma was associated with blunted cortisol reactivity to a laboratory stressor and resting cortisol levels in suicide attempters and ideators...
November 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29150404/stress-hormones-concentrations-in-the-normal-microenvironment-predict-risk-for-chemically-induced-cancer-in-rats
#14
Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29150403/the-cortisol-reactivity-threshold-model-direction-of-trait-rumination-and-cortisol-reactivity-association-varies-with-stressor-severity
#15
Suzanne Vrshek-Schallhorn, Bradley M Avery, Maria Ditcheva, Vaibhav R Sapuram
Various internalizing risk factors predict, in separate studies, both augmented and reduced cortisol responding to lab-induced stress. Stressor severity appears key: We tested whether heightened trait-like internalizing risk (here, trait rumination) predicts heightened cortisol reactivity under modest objective stress, but conversely predicts reduced reactivity under more robust objective stress. Thus, we hypothesized that trait rumination would interact with a curvilinear (quadratic) function of stress severity to predict cortisol reactivity...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29132028/dna-methylation-and-genetic-variation-of-the-angiotensin-converting-enzyme-ace-in-depression
#16
Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Richard Saffery, Joanne Ryan
BACKGROUND: Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation. OBJECTIVE: To investigate ACE promoter methylation as a biomarker of late-life depression, and its association with genetic variation and cortisol secretion...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29153629/elevated-fingernail-cortisol-levels-in-major-depressive-episodes
#17
Andres Herane-Vives, Susanne Fischer, Valeria de Angel, Toby Wise, Eric Cheung, Kia-Chong Chua, Danilo Arnone, Allan H Young, Anthony J Cleare
BACKGROUND: The extent to which cortisol levels are elevated in major depressive episodes (MDE), and hence could act as a biomarker of illness, remains unclear. Although patient characteristics may explain some of this variation - for example elevated cortisol being more often found in patients with severe, psychotic or melancholic depression - problems with the methods used to measure cortisol may also have contributed to the inconsistent findings. Fingernails are a novel sample that can be used to assess aggregate cortisol concentrations over a 15-day period, and may provide a more accurate reflection of longer term cortisol level changes in MDE and help clarify this issue...
November 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29195161/prenatal-and-pubertal-testosterone-affect-brain-lateralization
#18
T Beking, R H Geuze, M van Faassen, I P Kema, B P C Kreukels, T G G Groothuis
After decades of research, the influence of prenatal testosterone on brain lateralization is still elusive, whereas the influence of pubertal testosterone on functional brain lateralization has not been investigated, although there is increasing evidence that testosterone affects the brain in puberty. We performed a longitudinal study, investigating the relationship between prenatal testosterone concentrations in amniotic fluid, pubertal testosterone concentrations in saliva, and brain lateralization (measured with functional Transcranial Doppler ultrasonography (fTCD)) of the Mental Rotation, Chimeric Faces and Word Generation tasks...
November 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29112905/determinants-of-hair-cortisol-concentration-in-children-a-systematic-review
#19
REVIEW
N A Gray, A Dhana, L Van Der Vyver, J Van Wyk, N P Khumalo, D J Stein
BACKGROUND: Several factors are known contribute to hair cortisol concentration (HCC) in adults. However, there is less research on determinants of HCC in children and adolescents. HCC is a valuable tool for medical research pertaining to the hypothalamic-pituitary-adrenal (HPA) axis. This review aims to assess the extent to which established determinants of HCC in adults have been consistently reported in children (birth - 18 years) and to identify determinants of HCC specific to this age group...
November 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29107881/increased-estrogen-level-can-be-associated-with-depression-in-males
#20
Daniela Stanikova, Tobias Luck, Yoon Ju Bae, Joachim Thiery, Uta Ceglarek, Christoph Engel, Cornelia Enzenbach, Kerstin Wirkner, Juraj Stanik, Juergen Kratzsch, Steffi G Riedel-Heller
BACKGROUND: Several studies have shown a positive association between depression and obesity; however the underlying mechanisms are not fully understood. It is not known if this association is driven by altered sex hormone levels in men due to increased BMI. PATIENTS AND METHODS: Data were obtained from the LIFE-Adult-Study, a population-based cohort study. A total of 3925 men (2244<60years and 1681>60years) were included into analyses. Associations between BMI, sex hormones and depressive symptomatology according to CES-D score were evaluated...
November 2, 2017: Psychoneuroendocrinology
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