Ying Guo, Minqi Li, Liu Zhusheng, Tamaki Yamada, Muneteru Sasaki, Tomoka Hasegawa, Hiromi Hongo, Chihiro Tabata, Reiko Suzuki, Kimimitsu Oda, Tsuneyuki Yamamoto, Masamitsu Kawanami, Norio Amizuka
This study aimed at elucidating whether estrogen deficiency would affect the synthesis of an osteocyte-derived factor, sclerostin, in the mesial region of alveolar bone. Eight 9-week-old Wistar female rats were ovariectomized (OVX) and eight other rats were Sham-operated (Sham). After 4 weeks, the interradicular septa of mandibular first molar were embedded in paraffin and then histochemically examined. Sclerostin-positive osteocytes were located in the superficial layer of the mesial region of Sham bones, whereas the OVX mesial region showed less sclerostin-reactive osteocytes...
2012: Journal of Electron Microscopy