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American Journal of Hematology

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https://www.readbyqxmd.com/read/29341268/evans-syndrome-secondary-to-undiagnosed-chronic-lymphocytic-leukemia-in-a-patient-with-unexplained-bleeding
#1
Christopher B Hergott, Olga Pozdnyakova
No abstract text is available yet for this article.
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29341241/pan-pseudothrombocytopenia-an-unusual-case-of-platelet-clumping
#2
Hany Elmariah, Satish Shanbhag
No abstract text is available yet for this article.
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29341235/concomitant-cutaneous-squamous-cell-carcinoma-and-cll-in-a-patient-the-utility-of-18-f-fdg-pet-ct-in-differentiation-of-nodal-metastasis
#3
Kerem Ozturk, Celalettin Ustun, Sobia Khaja, Faqian Li, Matthew Rischall, Zuzan Cayci
INTRODUCTION: Head and neck cutaneous squamous cell carcinoma (cSCC) often presents with cervical lymph node metastases. Lymphoma is the second most common malignancy in the cervical region, however, it is rarely synchronous with head and neck cSCC. METHODS: We describe the unusual presentation of a patient with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and metastatic head and neck cSCC on 18-fluorodeoxyglucose positron emission tomography (18 F-FDG PET/CT)...
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29341234/microangiopathy-and-acute-kidney-injury-in-paroxysmal-cold-haemoglobinuria-a-challenge-for-management
#4
Neill Storrar, Eve Miller-Hodges, John Neary, Jeremy Hughes, Nicole Priddee
No abstract text is available yet for this article.
January 17, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29327469/a-retrospective-survey-of-exposure-history-to-chemotherapy-or-radiotherapy-in-940-consecutive-patients-with-primary-myelofibrosis
#5
LETTER
Maura Nicolosi, Mythri Mudireddy, Mrinal M Patnaik, Naseema Gangat, Animesh Pardanani, Ayalew Tefferi
No abstract text is available yet for this article.
January 12, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29327376/urinary-orosomucoid-is-associated-with-progressive-chronic-kidney-disease-stage-in-patients-with-sickle-cell-anemia
#6
LETTER
Marina Jerebtsova, Santosh L Saraf, Simran Soni, Nowah Afangbedji, Xionghao Lin, Rasha Raslan, Victor R Gordeuk, Sergei Nekhai
No abstract text is available yet for this article.
January 12, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29322543/effect-of-eptifibatide-on-inflammation-during-acute-pain-episodes-in-sickle-cell-disease
#7
LETTER
Julia E Brittain, Ciprian Anea, Payal Desai, Jack Delaney, Adam McDonald, Stephen W Looney, Nigel S Key, Leslie V Parise, Kenneth I Ataga
No abstract text is available yet for this article.
January 11, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29322539/inhaled-corticosteroid-use-to-prevent-severe-vaso-occlusive-episode-recurrence-in-children-between-1-and-4-with-sickle-cell-disease-a-multicenter-feasibility-trial
#8
LETTER
Leah Vance Utset, Zalaya Ivy, Shaina M Willen, Mark Rodeghier, Amanda Watt, Leann Schilling, Chantel L Jenkins, Stefanie Pepper, Barbara Speller-Brown, Deepika S Darbari, Suvankar Majumdar, Olufolake Adisa, Michael R DeBaun
No abstract text is available yet for this article.
January 11, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29318701/factor-vii-deficiency-in-major-artery-occlusion-stroke
#9
Slaven Pikija, Simon Peter Gampenrieder, Katharina Millesi, Georg Pilz, Serge Weis, Johannes Sebastian Mutzenbach
No abstract text is available yet for this article.
January 10, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29318650/a-phase-ii-study-of-tacrolimus-and-thymoglobulin-as-graft-versus-host-disease-prophylaxis-in-related-donor-allogeneic-hematopoietic-cell-transplantation
#10
LETTER
Dipenkumar Modi, Zaid Al-Kadhimi, Wei Chen, Hyejeong Jang, Abhinav Deol, Lois Ayash, Divaya Bhutani, Asif Alavi, Voravit Ratanatharathorn, Joseph P Uberti
No abstract text is available yet for this article.
January 10, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29318647/realizing-effectiveness-across-continents-with-hydroxyurea-enrollment-and-baseline-characteristics-of-the-multicenter-reach-study-in-sub-saharan-africa
#11
Patrick T McGann, Thomas N Williams, Peter Olupot-Olupot, George A Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Santos, Léon Tshilolo, Russell E Ware
Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open-label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub-Saharan African countries...
January 10, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29318644/description-and-prognostic-significance-of-the-kinetics-of-minimal-residual-disease-status-in-adults-with-acute-lymphoblastic-leukemia-treated-with-hypercvad
#12
Ryan D Cassaday, Philip A Stevenson, Brent L Wood, Pamela S Becker, Paul C Hendrie, Brenda M Sandmaier, Jerald L Radich, Andrei R Shustov
HyperCVAD is a commonly-used regimen for adults with newly-diagnosed acute lymphoblastic leukemia (ALL). However, relatively little is known about the application of minimal residual disease (MRD) detection with this treatment. To address this, we studied 142 adults with ALL treated with hyperCVAD over a 10-year period who had MRD assessed by either multi-parameter flow cytometry or (for patients with Philadelphia chromosome positive ALL) reverse transcriptase polymerase chain reaction for the BCR-ABL1 translocation...
January 10, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29314230/reply-to-castillo-et-al
#13
LETTER
Jithma P Abeykoon, Rebecca King, Stephen M Ansell, S Vincent Rajkumar, Jonas Paludo, Robert A Kyle, Shaji Kumar, Morie A Gertz, Prashant Kapoor
No abstract text is available yet for this article.
January 5, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29314195/methylene-blue-induced-heinz-body-hemolytic-anemia-in-a-premature-neonate
#14
Lewis Vanhinsbergh, Sabita Uthaya, Barbara J Bain
No abstract text is available yet for this article.
January 5, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29314145/toward-complement-inhibition-2-0-next-generation-anti-complement-agents-for-paroxysmal-nocturnal-hemoglobinuria
#15
Antonio M Risitano, Serena Marotta
Therapeutic complement inhibition by eculizumab has revolutionized the treatment of paroxysmal nocturnal hemoglobinuria (PNH) with a major impact on its natural history. Nevertheless, emerging unmet clinical needs may benefit from the development of novel complement inhibitors. Novel strategies of complement inhibition exploit different agents targeting C5, as well as compound intercepting the complement cascade at the level of its key component C3, or even upstream at the level of components involved in complement alternative pathway initiation...
January 4, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29285804/centrifugation-free-washing-a-novel-approach-for-removing-iga-from-stored-red-blood-cells
#16
Eszter Vörös, Nathaniel Z Piety, Briony C Strachan, Madeleine Lu, Sergey S Shevkoplyas
Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation-based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4-6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using either the prototype washing system, or via conventional centrifugation...
December 29, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29285795/ataluren-driven-restoration-of-shwachman-bodian-diamond-syndrome-protein-function-in-shwachman-diamond-syndrome-bone-marrow-cells
#17
Valentino Bezzerri, Donatella Bardelli, Jacopo Morini, Antonio Vella, Simone Cesaro, Claudio Sorio, Andrea Biondi, Cesare Danesino, Piero Farruggia, Baroukh Maurice Assael, Giovanna D'Amico, Marco Cipolli
Shwachman-Diamond syndrome (SDS) is a rare inherited recessive disease mainly caused by mutations in the Shwachman-Bodian-Diamond syndrome (SBDS) gene, which encodes for the homonymous protein SBDS, whose function still remains to be fully established. SDS affects several organs causing bone marrow failure, exocrine pancreatic insufficiency, skeletal malformations, and cognitive disorders. About 15% of SDS patients develop myelodysplastic syndromes (MDS) and are at higher risk of developing acute myeloid leukemia (AML)...
December 29, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29285788/flt3-inhibitors-in-acute-myeloid-leukemia-choosing-the-best-when-the-optimal-does-not-exist
#18
REVIEW
Rita Assi, Farhad Ravandi
Despite significant advances in deciphering the molecular and cytogenetic pathways governing acute myeloid leukemia, improvements in treatment strategies and clinical outcomes have been limited. The discovery of FLT3 pathway and its potential role in leukemogenesis has generated excitement in the field and has provided a potential target for drug development. Despite setbacks encountered with first-generation inhibitors, we are witnessing an outbreak of novel agents with potent activity and improved pharmacodynamics which continue to generate promising results...
December 29, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29282755/fatal-cache-valley-virus-meningoencephalitis-associated-with-rituximab-maintenance-therapy
#19
Yuanquan Yang, Jingxin Qiu, Abigail Snyder-Keller, Yongping Wu, Shufeng Sun, Haixin Sui, Amy B Dean, Laura Kramer, Francisco Hernandez-Ilizaliturri
No abstract text is available yet for this article.
December 28, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29280186/ibrutinib-discontinuation-in-waldenstr%C3%A3-m-macroglobulinemia-etiologies-outcomes-and-igm-rebound
#20
Joshua N Gustine, Kirsten Meid, Toni Dubeau, Patricia Severns, Zachary R Hunter, Yang Guang, Lian Xu, Steven P Treon, Jorge J Castillo
Ibrutinib is the first approved therapy for symptomatic patients with Waldenström macroglobulinemia (WM). The reasons for discontinuing ibrutinib and subsequent outcomes have not been previously evaluated in WM patients. We therefore conducted a retrospective review of 189 WM patients seen at our institution who received treatment with ibrutinib, of whom 51 (27%) have discontinued therapy. Reasons for discontinuation include: disease progression (n=27; 14%), toxicity (n=15; 8%), non-response (n=5; 3%), and other unrelated reasons (n=4; 2%)...
December 27, 2017: American Journal of Hematology
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