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American Journal of Hematology

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https://www.readbyqxmd.com/read/28736939/fetal-hemoglobin-in-sickle-cell-anemia-the-arab-indian-haplotype-and-new-therapeutic-agents
#1
REVIEW
Alawi H Habara, Elmutaz M Shaikho, Martin H Steinberg
Fetal hemoglobin (HbF) has well-known tempering effects on the symptoms of sickle cell disease and its levels vary among patients with different haplotypes of the sickle hemoglobin gene. Compared with sickle cell anemia haplotypes found in patients of African descent, HbF levels in Saudi and Indian patients with the Arab-Indian (AI) haplotype exceed that in any other haplotype by nearly two-fold. Genetic association studies have identified some loci associated with high HbF in the AI haplotype but these observations require functional confirmation...
July 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28719025/frequency-risk-factors-and-outcomes-of-central-nervous-system-relapse-in-lymphoma-patients-treated-with-dose-adjusted-epoch-plus-rituximab
#2
M K Malecek, A M Petrich, S Rozell, B Chu, S Trifilio, N Galanina, M Maurer, U Farooq, B Link, G S Nowakowski, C Nabhan, A O Ayed
Background Central nervous system (CNS) relapse in non-Hodgkin lymphoma (NHL) is a rare but serious complication that carries a poor prognosis. The use of infusional etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) for frontline treatment of diffuse large B cell lymphoma (DLBCL) is increasing, though little is known about incidence of and risk factors for CNS relapse with this regimen Patients and methods We completed a chart review of patients with NHL who received EPOCH-R as front line therapy...
July 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28718956/somatic-mutations-identified-at-diagnosis-by-exome-sequencing-can-predict-response-to-imatinib-in-chronic-phase-cml-patients
#3
LETTER
Luca Mologni, Rocco Piazza, Praveen Khandelwal, Alessandra Pirola, Carlo Gambacorti-Passerini
No abstract text is available yet for this article.
July 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707436/pure-erythroid-leukemia-the-need-gather-data-on-this-condition-as-defined-in-the-world-health-organisation-classification
#4
LETTER
Barbara J Bain
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707429/clinical-significance-of-prothrombin-g20210a-mutation-in-homozygous-patients
#5
LETTER
Amit Shemesh, Ron Hoffman, Yona Nadir, Anat Keren-Politansky, Manuel Monreal, Benjamin Brenner, Inna Tzoran
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707414/nucleophosmin-1-npm1-mutations-in-chronic-myelomonocytic-leukemia-and-their-prognostic-relevance
#6
LETTER
Rangit Vallapureddy, Terra L Lasho, Katherine Hoversten, Christy M Finke, Rhett Ketterling, Curtis Hanson, Naseema Gangat, Ayalew Tefferi, Mrinal M Patnaik
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707398/causes-of-early-death-in-multiple-myeloma-patients-treated-with-high-dose-therapy-followed-by-autologous-stem-cell-transplantation-a-study-based-on-the-nationwide-danish-multiple-myeloma-registry
#7
LETTER
Kristian Thidemann Andersen, Tobias Klausen, Niels Abildgaard, Mette Klarskov Andersen, Niels Frost Andersen, Ulf Christian Frølund, Carsten Helleberg, Eigil Kjeldsen, Per Pedersen, Sissel Helm-Petersen, Asta Svirskaite, Birgitte Preiss, Peter Gimsing, Annette Juul Vangsted
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707397/response-to-dr-bain-s-comment-on-our-review-article-pure-erythroid-leukemia
#8
LETTER
Wei Wang, Sa Wang, L Jeffrey Medeiros, Joseph D Khoury
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707395/association-of-pancreatic-mri-r2-with-blood-glucose-and-cardiac-mri-r2-among-thalassemia-major-patients-in-indonesia
#9
LETTER
Pustika Amalia Wahidiyat, Damayanti Sekarsari, Nitish Basant Adnani, Siti Ayu Putriasih, Vasili Berdoukas
No abstract text is available yet for this article.
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28707371/individuals-with-sickle-cell-disease-have-a-significantly-greater-vasoconstriction-response-to-thermal-pain-than-controls-and-have-significant-vasoconstriction-in-response-to-anticipation-of-pain
#10
Maha Khaleel, Mammen Puliyel, Payal Shah, John Sunwoo, Roberta M Kato, Patjanaporn Chalacheva, Wanwara Thuptimdang, Jon Detterich, John C Wood, Jennie Tsao, Lonnie Zeltzer, Richard Sposto, Michael C K Khoo, Thomas D Coates
The painful vaso-occlusive crises (VOC) that characterize sickle cell disease (SCD) progress over hours from the asymptomatic steady-state. SCD patients report that VOC can be triggered by stress, cold exposure and pain itself. We anticipated that pain could cause neural-mediated vasoconstriction, decreasing regional blood flow and promoting entrapment of sickle cells in the microvasculature. Therefore, we measured microvascular blood flow in the fingers of both hands using plethysmography and laser-Doppler flowmetry while applying a series of painful thermal stimuli on the right forearm in 23 SCD patients and 25 controls...
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699161/a-postpartum-perfect-storm
#11
Adanma Ayanambakkam, Kerry C Owens, Jennifer J McIntosh, Carla M Nester, James N George
No abstract text is available yet for this article.
July 12, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699284/a-monocyte-tnf-endothelial-activation-axis-in-sickle-transgenic-mice-therapeutic-benefit-from-tnf-blockade
#12
Anna Solovey, Arif Somani, John D Belcher, Liming Milbauer, Lucile Vincent, Rafal Pawlinski, Karl A Nath, Robert J Kelm, Nigel Mackman, M Gerard O'Sullivan, Kalpna Gupta, Gregory M Vercellotti, Robert P Hebbel
Elaboration of tumor necrosis factor (TNF) is a very early event in development of ischemia/reperfusion injury pathophysiology. Therefore, TNF may be a prominent mediator of endothelial cell and vascular wall dysfunction in sickle cell anemia, a hypothesis we addressed using NY1DD, S+S(Antilles) , and SS-BERK sickle transgenic mice. Transfusion experiments revealed participation of abnormally activated blood monocytes exerting an endothelial activating effect, dependent upon Egr-1 in both vessel wall and blood cells, and upon NFκB(p50) in a blood cell only...
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699283/prospective-evaluation-of-chronic-organ-damage-in-adult-sickle-cell-patients-a-seven-year-follow-up-study
#13
Charlotte F J van Tuijn, Marein Schimmel, Eduard J van Beers, Erfan Nur, Bart J Biemond
Organ damage in sickle cell disease (SCD) is a crucial determinant for disease severity and prognosis. In a previous study, we analyzed the prevalence of SCD-related organ damage and complications in adult sickle cell patients. We now describe a seven-year follow-up of this cohort. All patients from the primary analysis in 2006 (n=104), were included for follow-up. Patients were screened for SCD-related organ damage and complications (microalbuminuria, renal failure, elevated tricuspid regurgitation flow velocity (TRV) (≥2...
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699264/poems-syndrome-an-elusive-diagnosis
#14
Jithma P Abeykoon, Wilson I Gonsalves, Jennifer Oliveira, Prashant Kapoor
No abstract text is available yet for this article.
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699256/long-term-analysis-of-phase-ii-studies-of-single-agent-lenalidomide-in-relapsed-refractory-mantle-cell-lymphoma
#15
Thomas E Witzig, Pier Luigi Zinzani, Thomas M Habermann, Joseph M Tuscano, Johannes Drach, Radhakrishnan Ramchandren, Sevgi Kalayoglu Besisik, Kenichi Takeshita, Marie-Laure Casadebaig Bravo, Lei Zhang, Tommy Fu, Andre Goy
Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma (NHL) with aggressive disease characteristics resulting in multiple relapses after initial treatment. Lenalidomide is an immunomodulatory agent approved in the US for patients with relapsed/refractory MCL following bortezomib based on results from 3 multicenter phase II studies (2 including relapsed/refractory aggressive NHL and 1 focusing on MCL post-bortezomib). The purpose of this report is to provide longer follow-up on the MCL-001 study (follow-ups were 6...
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699249/targeted-next-generation-sequencing-identifies-a-novel-%C3%A3-spectrin-gene-mutation-a2059p-in-two-omani-children-with-hereditary-pyropoikilocytosis
#16
LETTER
Arwa Z Al-Riyami, Achille Iolascon, Shoaib Al-Zadjali, Immacolata Andolfo, Sahima Al-Mammari, Francesco Manna, AbdulHakim Al Rawas, May-Jean King, Roberta Russo
No abstract text is available yet for this article.
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699225/intensive-consolidation-with-g-csf-support-tolerability-safety-reduced-hospitalization-and-efficacy-in-aml-patients-%C3%A2-60-years
#17
Wolfgang R Sperr, Susanne Herndlhofer, Karoline Gleixner, Michael Girschikofsky, Ansgar Weltermann, Sigrid Machherndl-Spandl, Thamer Sliwa, Rainer Poehnl, Veronika Buxhofer-Ausch, Karin Strecker, Gregor Hoermann, Paul Knoebl, Ulrich Jaeger, Klaus Geissler, Michael Kundi, Peter Valent
The aim of this study was to evaluate the efficacy and feasibility of intensified consolidation therapy employing fludarabine and ARA-C in cycle 1 and intermediate-dose ARA-C (IDAC) in cycles 2 through 4, in elderly acute myeloid leukemia (AML) patients and to analyze the effects of pegfilgrastim on the duration of neutropenia, overall toxicity, and hospitalisation-time during consolidation in these patients. Thirty nine elderly patients with de novo AML (median age 69.9 years) who achieved complete remission (CR) after induction-chemotherapy were analyzed...
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699191/a-re-appraisal-of-the-benefit-risk-profile-of-hydroxyurea-in-polycythemia-vera-a-propensity-matched-study
#18
Tiziano Barbui, Alessandro M Vannucchi, Guido Finazzi, Maria Chiara Finazzi, Arianna Masciulli, Alessandra Carobbio, Arianna Ghirardi, Gianni Tognoni
The use of Hydroxyurea (HU) as first line therapy in polycythemia vera (PV) has been criticized because no solid demonstration that this drug prevents thrombosis or prolongs survival has been so far produced. Here we present the outcomes of a large cohort of patients with PV included in the European Collaborative Low-dose Aspirin (ECLAP) study. We selected 1,042 patients who, during the follow-up, had received only phlebotomy (PHL) or HU to maintain the hematocrit level<45%. To assure comparability, we conducted a propensity score matching analysis...
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699185/chromosome-6q-deletion-correlates-with-poor-prognosis-and-low-relative-expression-of-foxo3-in-chronic-lymphocytic-leukemia-patients
#19
LETTER
Marie Jarosova, Martina Hruba, Alexandra Oltova, Karla Plevova, Lenka Kruzova, Eva Kriegova, Regina Fillerova, Eva Koritakova, Michael Doubek, Daniel Lysak, Vit Prochazka, Marek Mraz, Karel Indrak, Tomas Papajik
No abstract text is available yet for this article.
July 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28699171/alpha-1-antitrypsin-for-the-treatment-of-steroid-refractory-acute-gastrointestinal-graft-versus-host-disease
#20
LETTER
James H Jerkins, Mehdi Hamadani, Felicia Zook, Narendranath Epperla, Bronwen E Shaw, Wael Saber, J Douglas Rizzo, Marcelo Pasquini, Saurabh Chhabra, William R Drobyski, Parameswaran N Hari, Nirav N Shah
No abstract text is available yet for this article.
July 11, 2017: American Journal of Hematology
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