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American Journal of Hematology

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https://www.readbyqxmd.com/read/28439985/the-utility-of-mass-fix-to-detect-and-monitor-monoclonal-proteins-in-the-clinic
#1
Paolo Milani, David L Murray, David R Barnidge, Mindy C Kohlhagen, John R Mills, Giampaolo Merlini, Surendra Dasari, Angela Dispenzieri
The detection and quantification of monoclonal-proteins (M-proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias. Immunoglobulin enrichment-coupled with matrix-assisted laser desorption ionization time-of-flight mass-spectrometry (MASS-FIX) is a simple and inexpensive method to identify M-proteins, but its clinical generalizability has not yet been elucidated. We compared MASS-FIX to protein electrophoresis (PEL), serum/urine immunofixation-electrophoresis (IFE) and quantitative serum free-light chain (FLC) for the identification of M-proteins in different clinical diagnoses...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439953/feasibility-trial-for-primary-stroke-prevention-in-children-with-sickle-cell-anemia-in-nigeria-spin-trial
#2
Najibah Galadanci, Shehu Umar Abdullahi, Leah D Vance, Abdulkadir Musa Tabari, Shehi Ali, Raymond Belonwu, Auwal Salihu, Aisha Amal Galadanci, Binta Wudil Jibir, Halima Bello-Manga, Kathleen Neville, Fenella J Kirkham, Yu Shyr, Sharon Phillips, Brittany V Covert, Adetola A Kassim, Lori C Jordan, Muktar H Aliyu, Michael R DeBaun
The vast majority of children with sickle cell anemia (SCA) live in Africa, where evidence-based guidelines for primary stroke prevention are lacking. In Kano, Nigeria, we conducted a feasibility trial to determine the acceptability of hydroxyurea therapy for primary stroke prevention in children with abnormal transcranial Doppler (TCD) measurements. Children with SCA and abnormal non-imaging TCD measurements (≥ 200 cm/s) received moderate fixed-dose hydroxyurea therapy (∼20 mg/kg/day). A comparison group of children with TCD measurements < 200 cm/s was followed prospectively...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439943/botryoid-nuclei-resulting-from-cocaine-abuse
#3
Maurizio Fumi, Ylenia Pancione, Silvia Sale, Vincenzo Rocco, Barbara J Bain
No abstract text is available yet for this article.
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439916/real-world-results-of-ibrutinib-in-relapsed-refractory-cll-in-france-early-results-on-a-large-series-of-428-patients
#4
LETTER
Loic Ysebaert, Thérèse Aurran-Schleinitz, Caroline Dartigeas, Marie-Sarah Dilhuydy, Pierre Feugier, Anne-Sophie Michallet, Olivier Tournilhac, Jehan Dupuis, Pierre Sinet, Claire Albrecht, Florence Cymbalista
No abstract text is available yet for this article.
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439910/abo-incompatibility-in-mismatched-unrelated-donor-allogeneic-hematopoietic-cell-transplantation-for-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-the-ebmt
#5
Jonathan Canaani, Bipin N Savani, Myriam Labopin, Mauricette Michallet, Charles Craddock, Gerard Socié, Lisa Volin, Johan A Maertens, Charles Crawley, Didier Blaise, Per T Ljungman, Jan Cornelissen, Nigel Russell, Frédéric Baron, Norbert Gorin, Jordi Esteve, Fabio Ciceri, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Arnon Nagler
ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibility affects outcome in MMURD transplantation for acute myeloid leukemia (AML) patients is unknown. We evaluated 1013 AML patients who underwent MMURD transplantation between 2005 and 2014. Engraftment rates were comparable between ABO matched and mismatched patients, as were relapse incidence [34%; 95% confidence interval (CI), 28-39; for ABO matched vs...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437875/heterogeneity-of-neutrophil-spontaneous-death
#6
LETTER
Yan Teng, Hongbo R Luo, Hiroto Kambara
No abstract text is available yet for this article.
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437873/high-prevalence-of-monoclonal-gammopathy-among-patients-with-warm-autoimmune-hemolytic-anemia
#7
LETTER
Aishwarya Ravindran, Janani Sankaran, Eapen K Jacob, Justin D Kreuter, C Christopher Hook, Morie A Gertz, Timothy G Call, Rajiv K Pruthi, Mark R Litzow, Alexandra P Wolanskyj, William J Hogan, Aneel A Ashrani, Kebede H Begna, Ariela L Marshall, Robert A Kyle, Neil E Kay, Ronald S Go
No abstract text is available yet for this article.
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437868/early-mortality-and-overall-survival-of-acute-myeloid-leukemia-based-on-facility-type
#8
Vijaya R Bhatt, Valerie Shostrom, Smith Giri, Krishna Gundabolu, K M Monirul Islam, Frederick R Appelbaum, Lori J Maness
Cancer health disparities may exist based on the facility type. We aimed to determine the association between the academic status of centers and outcomes of patients with acute myeloid leukemia (AML). Using the National Cancer Data Base, we compared one-month mortality and longer-term overall survival (OS) of 60,738 patients with AML, who received first course treatment between 2003-2011 at academic or non-academic centers (community cancer program, comprehensive community cancer program, and others). Multivariate analysis was done using logistic regression for one-month mortality and Cox regression with backward elimination approach for OS...
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437849/clinical-significance-of-ige-in-a-large-cohort-of-patients-with-moderate-or-severe-chronic-graft-versus-host-disease
#9
LETTER
Sencer Goklemez, Filip Pirsl, Lauren M Curtis, Seth M Steinberg, Edward W Cowen, Jacqueline W Mays, Meg Kenyon, Judy Baruffaldi, Fran T Hakim, Steven Z Pavletic
No abstract text is available yet for this article.
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28437847/the-impact-of-sample-site-and-storage-on-thromboelastography-values
#10
LETTER
Mari Tuovila, Tiina Erkinaro, Eeva-Riitta Savolainen, Paivi Laurila, Pasi Ohtonen, Tero Ala-Kokko
No abstract text is available yet for this article.
April 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28403526/cd105-expression-in-early-erythroid-precursors
#11
LETTER
José Antonio García-Vela, Isaac Martin Rubio, Juan Marquet, Miguel Angel Alvarez Juarez
No abstract text is available yet for this article.
April 12, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28403512/mitotic-figure-in-the-peripheral-blood-smear
#12
Sebastian Hörber, Ingo Rettig, Andreas Peter
A previously healthy 19-year-old man presented with fever, sore throat and strong feeling of illness. Physical examination showed strong swelling of throat tonsils and moderate hepatosplenomegaly. The laboratory values were as following: a total white blood count of 10.9 x 10(9) /L, hemoglobin 14.1 g/dL and a platelet count of 109 x 10(9) /L. Total bilirubin was 1.4 mg/dL and CRP was 1.32 mg/dL. The serological analyses revealed IgG and IgM antibodies against EBV-VCA consistent with an acute Epstein-Barr virus infection...
April 12, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28402581/akt-inhibitor-mk-2206-in-combination-with-bendamustine-and-rituximab-in-relapsed-or-refractory-chronic-lymphocytic-leukemia-results-from-the-n1087-alliance-study
#13
Jeremy T Larsen, Tait D Shanafelt, Jose F Leis, Betsy LaPlant, Tim Call, Adam Pettinger, Curtis Hanson, Charles Erlichman, Thomas Matthew Habermann, Craig Reeder, Daniel Nikcevich, Deborah Bowen, Michael Conte, Justin Boysen, Charla Secreto, Connie Lesnick, Renee Tschumper, Diane Jelinek, Neil E Kay, Wei Ding
Akt is a downstream target of B cell receptor signaling and is a central regulator of CLL cell survival. We aim to investigate the safety and efficacy of the Akt inhibitor MK-2206 in combination with bendamustine and rituximab (BR) in relapsed and/or refractory CLL in a phase I/II study. A standard phase I design was used with cohorts of three plus three patients to determine the maximum tolerated dose (MTD) of MK-2206 in combination with BR in relapsed CLL. Single-agent MK-2206 (weekly dosed) was administered one-week in advance before BR on cycle 1 and subsequently was given with BR at the same time for cycle 2-6...
April 12, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28395132/a-somatic-mosaicism-in-the-g6pd-gene-inducing-a-late-onset-chronic-non-spherocytic-hemolytic-anemia
#14
LETTER
Lucile Couronné, Gérard Tertian, Audrey Boutron, Véronique Picard, Patricia Hughes, Olivier Hermine, Claude Préhu, Gil Tchernia, Loïc Garçon
No abstract text is available yet for this article.
April 10, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28388835/clinical-outcomes-in-a-cohort-of-patients-with-heparin-induced-thrombocytopenia
#15
David J Kuter, Barbara A Konkle, Taye H Hamza, Lynne Uhl, Susan F Assmann, Joseph E Kiss, Richard M Kaufman, Nigel S Key, Bruce S Sachais, John R Hess, Paul Ness, Keith R McCrae, Cindy Leissinger, Ronald G Strauss, Janice G McFarland, Ellis Neufeld, James B Bussel, Thomas L Ortel
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder usually prompting treatment with non-heparin anticoagulants. The benefits and risks of such treatments have not been fully assessed. METHODS: We analyzed data for 442 patients having a positive heparin-platelet factor 4 antibody test and recent heparin exposure. The primary outcome was a composite endpoint (death, limb amputation/gangrene, or new thrombosis). Secondary outcomes included bleeding and the effect of anticoagulation...
April 7, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28383205/igm-myeloma-a-multicenter-retrospective-study-of-134-patients
#16
Jorge J Castillo, Artur Jurczyszyn, Lucie Brozova, Edvan Crusoe, Jacek Czepiel, Julio Davila, Angela Dispenzieri, Marion Eveillard, Mark A Fiala, Irene M Ghobrial, Alessandro Gozzetti, Joshua N Gustine, Roman Hajek, Vania Hungria, Jiri Jarkovsky, David Jayabalan, Jacob P Laubach, Barbara Lewicka, Vladimir Maisnar, Elisabet E Manasanch, Philippe Moreau, Elizabeth A Morgan, Hareth Nahi, Ruben Niesvizky, Claudia Paba-Prada, Tomas Pika, Ludek Pour, John L Reagan, Paul G Richardson, Jatin Shah, Ivan Spicka, Ravi Vij, Anna Waszczuk-Gajda, Morie A Gertz
IgM myeloma is a rare hematologic malignancy for which the clinicopathological features and patient outcomes have not been extensively studied. We carried out a multicenter retrospective study in patients with diagnosis of IgM myeloma defined by >10% marrow involvement by monoclonal plasma cells, presence of an IgM monoclonal paraproteinemia of any size, and anemia, renal dysfunction, hypercalcemia, lytic lesions and/or t(11;14) identified by FISH. A total of 134 patients from 20 centers were included in this analysis...
April 6, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28383148/-anemia-is-present-years-before-myelodysplastic-syndrome-diagnosis-results-from-the-pre-diagnostic-period
#17
LETTER
Jakob Werner Hansen, Håkon Sandholdt, Volkert Siersma, Andreas Due Ørskov, Staffan Holmberg, Ole Weis Bjerrum, Hans Carl Hasselbalch, Niels F Olivarius, Kirsten Groenbaek, Christen Andersen
No abstract text is available yet for this article.
April 6, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28383130/clinical-characteristics-and-prognostic-factors-in-multiple-myeloma-patients-with-light-chain-deposition-disease
#18
Meera Mohan, Amy Buros, Pankaj Mathur, Neriman Gokden, Manisha Singh, Sandra Susanibar, Jorge Jo Kamimoto, Shadiqul Hoque, Muthukumar Radhakrishnan, Aasiya Matin, Cynthia Davis, Monica Grazziutti, Sharmilan Thanendrarajan, Frits van Rhee, Maurizio Zangari, Faith Davies, Gareth Morgan, Joshua Epstein, Bart Barlogie, Carolina Schinke
Light chain deposition disease (LCDD) is characterized by monotypic immunoglobulin depositions which will eventually lead to loss of organ function if left untreated. While the kidney is almost always affected, the presence and degree of LCDD in other organs vary. Ten to 30% of LCDD patients have underlying Multiple Myeloma (MM), yet outcome and prognostic markers in this particular patient group are still lacking. Here, we analyzed 69 patients with MM and biopsy proven LCDD and report on renal and extra-renal involvement and its impact on prognosis as well as renal response depending on hematologic response...
April 6, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28383114/monosomal-karyotype-in-chronic-lymphocytic-leukemia-association-with-clinical-and-biological-features-and-potential-prognostic-significance
#19
LETTER
Maria Joao Baptista, Isabel Granada, Mireia Morgades, María-José Calasanz, Jordi Canals, Diego Robles De Castro, Elisa Luño, Neus Ruiz-Xivillé, Inés Rodríguez-Hernández, Teresa González, María-José Terol, Alberto Valiente, Francisco Ortuño, María-Dolores Garcia-Malo, María-Ángeles Piñan, Ana Carla Oliveira, Maria Talavera, Ismael Buño, Ana Batlle-López, Carol Moreno, Christelle Ferra, Francesc Solé
No abstract text is available yet for this article.
April 6, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28383112/associations-between-elevated-pre-treatment-serum-cytokines-and-peripheral-blood-cellular-markers-of-immunosuppression-in-patients-with-lymphoma
#20
Moritz Binder, Megan M O'Byrne, Matthew J Maurer, Stephen Ansell, Andrew L Feldman, James Cerhan, Anne Novak, Luis Francisco Porrata, Svetomir Markovic, Brian K Link, Thomas E Witzig
Higher ratios of the pre-treatment peripheral blood absolute lymphocyte (ALC) to absolute monocyte counts (AMC) are associated with improved outcomes in lymphoma. Conversely, elevated pre-treatment serum cytokines are associated with inferior outcomes. The relationship between pre-treatment serum cytokines and ALC/AMC ratios remains unknown. We studied twelve serum cytokines and the ALC/AMC ratios in 390 patients with untreated diffuse large B-cell, follicular, mantle cell, T-cell, and Hodgkin lymphoma. Different pre-treatment serum cytokine concentrations correlated with ALC, AMC, and ALC/AMC ratios depending on the lymphoma type...
April 6, 2017: American Journal of Hematology
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