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American Journal of Hematology

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https://www.readbyqxmd.com/read/27883206/diffuse-pulmonary-extramedullary-hematopoiesis-in-myelofibrosis-diagnosed-with-technetium-99m-sulfur-colloid-bone-marrow-scintigraphy-and-single-photon-emission-computerized-tomography-ct
#1
Ming Yang, Michael Roarke
No abstract text is available yet for this article.
November 24, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27883199/hepcidin-detects-iron-deficiency-in-sri-lankan-adolescents-with-a-high-burden-of-hemoglobinopathy-a-diagnostic-test-accuracy-study
#2
Katherine Wray, Angela Allen, Emma Evans, Chris Fisher, Anuja Premawardhena, Lakshman Perera, Rexan Rodrigo, Gayan Goonathilaka, Lebbe Ramees, Craig Webster, Andrew E Armitage, Andrew M Prentice, David J Weatherall, Hal Drakesmith, Sant-Rayn Pasricha
Anemia affects over 800 million women and children globally. Measurement of hepcidin as an index of iron status shows promise, but its diagnostic performance where hemoglobinopathies are prevalent is unclear. We evaluated the performance of hepcidin as a diagnostic test of iron deficiency in adolescents across Sri Lanka. We selected 2273 samples from a nationally representative cross-sectional study of 7526 secondary schoolchildren across Sri Lanka and analyzed associations between hepcidin and participant characteristics, iron indices, inflammatory markers and hemoglobinopathy states...
November 24, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27880985/daily-pain-in-adults-with-sickle-cell-disease-a-different-perspective
#3
Charlotte F J van Tuijn, Joep W R Sins, Karin Fijnvandraat, Bart J Biemond
Previous reports demonstrated that patients with sickle cell disease (SCD) experience pain on more than half of the observed days. Yet, these high incidences do not seem to match observations in our population. In this prospective cohort study we aimed to assess the frequency and characteristics of daily, self-reported pain among adult SCD patients in the Netherlands. Consecutive patients were enrolled during routine outpatient visits and followed up to 6 months. A total of 55 patients completed 5 982 diary observation days...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27880984/diffuse-large-b-cell-lymphoma-with-primary-treatment-failure-ultra-high-risk-features-and-benchmarking-for-experimental-therapies
#4
Luciano J Costa, Kami Maddocks, Narendranath Epperla, Nishitha M Reddy, Reem Karmali, Elvira Umyarova, Veronika Bachanova, Christiana Costa, Martha Glenn, Julio Chavez, Oscar Calzada, Frederick Lansigan, Hossain Nasheed, Stefan Barta, Zheng Zhou, Michael Jaglal, Saurabh Chhabra, Francisco Hernandez-Ilizaliturri, Ana C Xavier, Amitkumar Mehta, Deniz Peker, Andreas Forero-Torres, Zeina Al-Mansour, Andrew M Evens, Jonathon B Cohen, Christopher R Flowers, Timothy S Fenske, Mehdi Hamadani
While a subset of patients with DLBCL relapsing after upfront chemoimmunotherapy can be cured with salvage therapy and autologous hematopoietic cell transplantation (auto-HCT), the outcome of patients with primary treatment failure (PTF) is less clear. For this study we analyzed 331 patients from 15 US institutions with DLBCL and PTF, defined as primary progression while on upfront chemoimmunotherapy (PP), residual disease at the end of upfront therapy (RD) or relapse < 6 months from end of therapy (early relapse; ER)...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27880982/safety-and-efficacy-of-ruxolitinib-in-splanchnic-vein-thrombosis-associated-with-myeloproliferative-neoplasms
#5
Lisa Pieri, Chiara Paoli, Umberto Arena, Fabio Marra, Fabio Mori, Mery Zucchini, Stefano Colagrande, Alessandro Castellani, Arianna Masciulli, Vittorio Rosti, Valerio De Stefano, Silvia Betti, Guido Finazzi, Maria Luisa Ferrari, Elisa Rumi, Marco Ruggeri, Ilaria Nichele, Paola Guglielmelli, Rajmonda Fjerza, Carmela Mannarelli, Tiziana Fanelli, Lucia Merli, Giuditta Corbizi Fattori, Margherita Massa, Giuseppe Cimino, Alessandro Rambaldi, Giovanni Barosi, Mario Cazzola, Tiziano Barbui, Alessandro M Vannucchi
Splanchnic vein thrombosis (SVT) is one of the vascular complications of myeloproliferative neoplasms (MPN). We designed a phase 2 clinical trial to evaluate safety and efficacy of ruxolitinib in reducing splenomegaly and improving disease-related symptoms in patients with MPN-associated SVT. Patients, diagnosed with myelofibrosis in 12 cases, polycythemia vera in 5 and essential thrombocythemia in 4, received ruxolitinib for 24 weeks in the core study period. Spleen volume was assessed by magnetic resonance imaging (MRI) and splanchnic vein circulation by echo-Doppler analysis...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27880980/impact-of-total-body-irradiation-on-successful-neutrophil-engraftment-in-unrelated-bone-marrow-or-cord-blood-transplantation
#6
Hideki Nakasone, Fuji Shigeo, Kimikazu Yakushijin, Makoto Onizuka, Akihito Shinohara, Kazuteru Ohashi, Koichi Miyamura, Naoyuki Uchida, Minoko Takanashi, Tatsuo Ichinohe, Yoshiko Atsuta, Takahiro Fukuda, Masao Ogata
Total body irradiation (TBI) has been thought to promote donor cell engraftment in allogeneic hematopoietic cell transplantation (HCT) from alternative donors. However, recent progress in HCT strategies may affect the clinical significance of TBI on neutrophil engraftment. With the use of a Japanese transplant registry database, we analyzed 3933 adult recipients (>15 y.o.) who underwent HCT between 2006 and 2013 from an 8/8 HLA-matched unrelated bone marrow donor (MUD, n=1367), an HLA-mismatched unrelated bone marrow donor (MMUD, n=1102), or unrelated cord blood (CBT, n=1464)...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27874212/dorsal-column-myelopathy-after-intrathecal-chemotherapy-for-leukemia
#7
Chelsea C Pinnix, Linda Chi, Elias J Jabbour, Sarah A Milgrom, Grace L Smith, Naval Daver, Naveen Garg, Matthew D Cykowski, Greg Fuller, David Cachia, Carlos Kamiya, Karin Woodman, Courtney Dinardo, Nitin Jain, Tapan M Kadia, Naveen Pemmaraju, Maro Ohanian, Marina Konopleva, Hagop M Kantarjian, Bouthaina S Dabaja
Intrathecal chemotherapy with methotrexate, a folate antagonist, is widely used to treat central nervous system malignancies. The mechanisms underlying methotrexate-induced neurotoxicity are unclear but may be related to increased homocysteine levels. Intrathecal methotrexate-induced myelopathy mimicking sub-acute combined degeneration, with normal B12 levels, has been documented. We examined treatment and magnetic resonance imaging (MRI) characteristics of 13 patients with leukemia who received intrathecal methotrexate and developed urinary and bowel incontinence, ascending motor weakness, and sensory loss with dorsal column hyper-intensity on MRI between 2000 and 2016...
November 22, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27870194/gray-platelet-syndrome-novel-mutations-of-the-nbeal2-gene
#8
LETTER
R Bottega, E Nicchia, C Alfano, A C Glembotsky, A Pastore, D Bertaggia-Calderara, B Bisig, M A Duchosal, G Arbesú, L Alberio, P G Heller, A Savoia
No abstract text is available yet for this article.
November 21, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27859620/tissue-polymerase-chain-reaction-for-the-diagnosis-of-cytomegalovirus-disease-after-allogeneic-stem-cell-transplantation
#9
LETTER
Armin Rashidi, Kiran R Vij, Richard S Buller, Kristine M Wylie, Gregory A Storch, John F DiPersio
No abstract text is available yet for this article.
November 17, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27859518/ixazomib-cardiotoxicity-a-possible-class-effect-of-proteasome-inhibitors
#10
Hayan Jouni, Mary C Aubry, Martha Q Lacy, S Vincent Rajkumar, Shaji K Kumar, Robert L Frye, Joerg Herrmann
No abstract text is available yet for this article.
November 17, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27859564/excess-mortality-in-the-myelodysplastic-syndromes
#11
Meritxell Nomdedeu, Arturo Pereira, Fernando Ramos, David Valcárcel, Dolors Costa, Montserrat Arnan, Xavier Calvo, Helena Pomares, Elisa Luño, María Díaz-Campelo, Rosa Collado, Raquel de Paz, José-Francisco Falantes, Carme Pedro, Josefa Marco, Itziar Oirtzabal, Joaquín Sánchez-García, Mar Tormo, María-Teresa Cedena, Benet Nomdedeu, Guillermo Sanz
Myelodysplastic syndromes (MDS) are the commonest hematologic malignancies in the elderly. Since many patients with MDS actually die from age-related ailments, the very disease burden of MDS remains largely unknown. This registry-based study was aimed at investigating the excess mortality attributable to MDS. We analyzed 7,408 adult patients diagnosed with primary MDS from 1980 to 2014. Excess mortality was estimated by comparing the patients' survival with that expected in the matched general population. Median age of patients was 74 years, 58% were males, and 65% belonged to the lower risk categories of the Revised International Prognostic Scoring System (IPSS-R)...
November 14, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27862221/philadelphia-chromosome-as-a-recurrent-event-among-therapy-related-acute-leukemia
#12
LETTER
Ibrahim Aldoss, Tracey Stiller, Joo Song, Monzr AlMalki, Haris Ali, Amandeep Salhotra, Ahmed Aribi, Samer Khaled, Popsie Gaytan, Joyce Murata-Collins, Joycelynne Palmer, David Snyder, Margaret O'Donnell, Ryotaro Nakamura, Anthony S Stein, Stephen J Forman, Guido Marcucci, Vinod Pullarkat
No abstract text is available yet for this article.
November 10, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27862214/the-role-of-acuity-of-illness-at-presentation-in-early-mortality-in-black-children-with-acute-myeloid-leukemia
#13
Lena E Winestone, Kelly D Getz, Tamara P Miller, Jennifer J Wilkes, Leah Sack, Yimei Li, Yuan-Shung Huang, Alix E Seif, Rochelle Bagatell, Brian T Fisher, Andrew Epstein, Richard Aplenc
Black patients with acute myeloid leukemia (AML) experience higher mortality than White patients. We compared induction mortality, acuity of illness prior to chemotherapy, and insurance type between Black and White patients to assess whether acuity of presentation mediates the disparity. Within a retrospective cohort of 1,122 children with AML treated with two courses of standard induction chemotherapy between 2004 to 2014 in the Pediatric Health Information System (PHIS) database, the association between race (Black versus White) and inpatient mortality during induction was examined...
November 10, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27862216/synchronous-presentation-of-intra-nodal-follicular-dendritic-cell-sarcoma-and-castleman-disease
#14
Preetesh Jain, Victor G Prieto, John T Manning, Nathan Fowler, L Jeffrey Medeiros, Rashmi Kanagal-Shamanna
No abstract text is available yet for this article.
November 8, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27862199/early-leukemic-transformation-of-adult-t-cell-leukemia-lymphoma-presenting-as-meningeal-lymphoma
#15
Barbara J Bain
No abstract text is available yet for this article.
November 8, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27813149/long-term-outcome-of-npm1-mutated-acute-myeloid-leukemia-a-single-institution-experience
#16
LETTER
Hamid Sayar, Parvaneh Bashardoust, Larry Cripe, Sujata Chakraborty, Shaochun Bai
No abstract text is available yet for this article.
November 4, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27813147/cardiotoxicity-risk-with-bortezomib-versus-lenalidomide-for-treatment-of-multiple-myeloma-a-propensity-matched-study-of-1-790-patients
#17
LETTER
John C Reneau, Dennis Asante, Holly Van Houten, Lindsey R Sangaralingham, Francis K Buadi, Amir Lerman, Joerg Herrmann
No abstract text is available yet for this article.
November 4, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27813144/arterio-venous-fistula-for-automated-red-blood-cells-exchange-in-patients-with-sickle-cell-disease-complications-and-outcomes
#18
Marianne Delville, Sandra Manceau, Nassim Ait Abdallah, Jan Stolba, Sameh Awad, Thibaud Damy, Barnabas Gellen, Laurent Sabbah, Karima Debbache, Vincent Audard, Jean-Louis Beaumont, Cécile Arnaud, Christelle Chantalat-Auger, Françoise Driss, François Lefrère, Marina Cavazzana, Franco Gilbert, Frederic Galacteros, Jean-Antoine Ribeil, Justine Gellen-Dautremer
Erythrocytapheresis (ER) can improve outcome in patients with sickle cell disease (SCD). A good vascular access is required but frequently it can be difficult to obtain for sickle cell patients. Arterio-venous fistulas (AVFs) have been suggested for ER in SCD supported by limited evidence. We report the largest cohort of ER performed with AVFs from three French sickle cell disease reference centers. Data of SCD patients undergoing ER with AVFs in the French SCD reference center were retrospectively collected...
November 4, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27806442/elevated-tricuspid-regurgitant-jet-velocity-reduced-forced-expiratory-volume-in-1-second-and-mortality-in-adults-with-sickle-cell-disease
#19
Shruti Chaturvedi, Djamila Labib Ghafuri, Adetola Kassim, Mark Rodeghier, Michael R DeBaun
Cardiopulmonary disease is the leading cause of mortality in adults with sickle cell disease (SCD). Elevated tricuspid regurgitant jet velocity (TRJV) and reduced forced expiratory volume in 1 second (FEV1 ) %predicted are associated with early mortality in SCD; however their relationship and combined effect on survival is unknown. We investigated the relationship between TRJV and FEV1 , and their combined effect on mortality, in a retrospective cohort of 189 adults with SCD who underwent both pulmonary function testing and echocardiography...
November 2, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27804182/validation-of-a-clinical-assay-of-multi-locus-dna-methylation-for-prognosis-of-newly-diagnosed-aml
#20
LETTER
Courtney D DiNardo, Marlise R Luskin, Martin Carroll, Catherine Smith, Jenna Harrison, Sherry Pierce, Steve Kornblau, Marina Konopleva, Tapan Kadia, Hagop Kantarjian, Gerald B Wertheim, Stephen R Master
No abstract text is available yet for this article.
November 2, 2016: American Journal of Hematology
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