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American Journal of Hematology

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https://www.readbyqxmd.com/read/28230270/a-phase-2-study-of-lenalidomide-rituximab-cyclophosphamide-and-dexamethasone-lr-cd-for-untreated-low-grade-non-hodgkin-lymphoma-requiring-therapy
#1
Allison Rosenthal, Amylou C Dueck, Stephen Ansell, Katherine Gano, Christopher Conley, Grzegorz S Nowakowski, John Camoriano, Jose F Leis, Joseph R Mikhael, A Keith Stewart, David Inwards, David Dingli, Shaji Kumar, Pierre Noel, Morie Gertz, Luis Porrata, Stephen Russell, Joseph Colgan, Rafael Fonseca, Thomas M Habermann, Prashant Kapoor, Francis Buadi, Nelson Leung, Rodger Tiedemann, Thomas E Witzig, Craig Reeder
Patients with indolent NHL have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy and safety of adding lenalidomide to rituximab, cyclophosphamide, and dexamethasone (LR-CD) in untreated indolent NHL patients requiring therapy. This was a single institution phase II trial. Treatment consisted of IV rituximab 375mg/m(2) day 1, oral lenalidomide 20mg days 1-21, cyclophosphamide 250mg/m(2) days 1, 8, 15, and dexamethasone 40mg days 1, 8, 15, 22, of a 28-day cycle...
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28230261/plasmodium-knowlesi
#2
Peter Chiodini, Barbara J Bain
No abstract text is available yet for this article.
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28230259/autoimmune-hemolytic-anemia-in-a-young-man-with-acute-hepatitis-e-infection
#3
LETTER
Rebecca Karp Leaf, Kerry L O'Brien, David E Leaf, Reed E Drews
No abstract text is available yet for this article.
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28230258/evaluation-of-the-efficiency-of-hydroxychloroquine-in-treating-children-with-immune-thrombocytopenia-itp
#4
LETTER
Ombeline Roche, Nathalie Aladjidi, Josué Rakotonjanahary, Guy Leverger, Thierry Leblanc, Caroline Thomas, Marlène Pasquet, Mary-France Courcoux, Sophie Bayart, Marion Gilibert-Yvert, Bénédicte Neven, Pierre Quartier, Isabelle Pellier
No abstract text is available yet for this article.
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28224669/publication-outcomes-of-abstracts-from-the-american-society-of-hematology-annual-meeting
#5
LETTER
Sujatha Baddam, Gary R Cutter, Julie A Wolfson, Gregory K Friedman, Jeffrey D Lebensburger
No abstract text is available yet for this article.
February 22, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28224664/gemcitabine-and-docetaxel-as-a-novel-treatment-regimen-for-blastic-plasmacytoid-dendritic-cell-neoplasm
#6
LETTER
Matthew L Ulrickson, Akshjot Puri, Sarah Lindstrom, Ryan D Cassaday, Nicolas De Padova, Pamela S Becker
No abstract text is available yet for this article.
February 22, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28224662/identification-of-renal-infiltration-based-on-urinary-findings-in-a-child-with-burkitt-leukemia-lymphoma
#7
Zühre Kaya, Nurettin Alıcı, Özlem Ezgi Özmen, Meltem Akgül, Büşra Topuz, Emine Akkuzu
No abstract text is available yet for this article.
February 22, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28220513/in-vivo-confocal-microscopy-of-multiple-myeloma-associated-crystalline-keratopathy
#8
Caleb Busch, Shizuka Koh, Yoshinori Oie, Michiko Ichii, Yuzuru Kanakura, Kohji Nishida
No abstract text is available yet for this article.
February 21, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28213943/a-phase-2-safety-study-of-accelerated-elotuzumab-infusion-over-less-than-1-hour-in-combination-with-lenalidomide-and-dexamethasone-in-patients-with-multiple-myeloma
#9
James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin
Elotuzumab, an immunostimulatory SLAMF7-targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3-hour infusion), combined with lenalidomide and dexamethasone, demonstrated durable efficacy and acceptable safety; 10% (33/321) of patients had infusion reactions (IRs; Grade 1/2: 29; Grade 3: 4). This phase 2 study (NCT02159365) investigated an accelerated infusion schedule in 70 patients with newly diagnosed multiple myeloma or RRMM...
February 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28213916/varicella-zoster-virus-meningoencephalitis-in-a-patient-treated-with-ruxolitinib
#10
LETTER
Ophir Eyal, Maayan Flaschner, Arie Ben Yehuda, Deborah Rund
No abstract text is available yet for this article.
February 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211167/concomitant-monitoring-of-wt1-and-flt3-itd-expression-in-flt3-itd-acute-myeloid-leukemia-patients-which-should-we-trust-as-a-minimal-residual-disease-marker
#11
LETTER
Federico De Marchi, Anna Candoni, Maria Elena Zannier, Wing Yin Bonnie Lau, Lisa Haley, Renato Fanin
No abstract text is available yet for this article.
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211162/efficacy-of-the-oral-mtorc1-inhibitor-everolimus-in-relapsed-or-refractory-indolent-lymphoma
#12
N Nora Bennani, Betsy R LaPlant, Stephen M Ansell, Thomas M Habermann, David J Inwards, Ivana N Micallef, Patrick B Johnston, Luis F Porrata, Joseph P Colgan, Svetomir N Markovic, Grzegorz S Nowakowski, William R Macon, Craig B Reeder, Joseph R Mikhael, Donald W Northfelt, Irene M Ghobrial, Thomas E Witzig
Relapsed indolent lymphoma often becomes refractory to standard chemoimmunotherapy and requires new therapeutic strategies. Targeting the PI3K/mTOR pathway in several types of lymphoma has shown preclinical and clinical efficacy providing the rationale to test this strategy in the treatment of relapsed/refractory indolent lymphomas. We investigated in a phase II open label clinical trial the efficacy and safety of single agent everolimus, an inhibitor of mTORC1, in patients with relapsed/refractory indolent lymphomas...
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211153/the-prognostic-relevance-of-serum-lactate-dehydrogenase-and-mild-bone-marrow-reticulin-fibrosis-in-essential-thrombocythemia
#13
Mythri Mudireddy, Daniela Barraco, Curtis A Hanson, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
The 2016 World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms (MPN) underscore the prognostically-relevant distinction between essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF). In addition, leukocytosis has been identified as an important prognostic marker in otherwise WHO-defined ET. However, controversy remains regarding the objectivity of morphologic criteria in distinguishing ET from pre-PMF and the precise prognostic cutoff values for leukocytosis...
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211104/dat-positive-plasmodium-ovale-malaria-presenting-in-a-child-with-sickle-cell-anemia
#14
Nicholas S Whipple, Jason R Schwartz, Kerri A Nottage
No abstract text is available yet for this article.
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211097/lifespan-care-in-scd-whom-to-transition-the-patients-or-the-health-care-system
#15
Caterina P Minniti, Elliott Vichinsky
No abstract text is available yet for this article.
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28196400/diagnostic-impact-of-the-2016-revised-who-criteria-for-polycythemia-vera
#16
Tiziano Barbui, Juergen Thiele, Heinz Gisslinger, Alessandra Carobbio, Alessandro M Vannucchi, Ayalew Tefferi
No abstract text is available yet for this article.
February 14, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28194886/prognostic-significance-of-cytogenetic-abnormalities-in-t-cell-prolymphocytic-leukemia
#17
Zhihong Hu, L Jeffrey Medeiros, Lianghua Fang, Yi Sun, Zhenya Tang, Guilin Tang, Tsieh Sun, Andres E Quesada, Shimin Hu, Sa A Wang, Lin Pei, Xinyan Lu
T-cell prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm. The most common cytogenetic abnormality associated with T-PLL is inv(14)(q11.2q32) involving TCL1, but other abnormalities also have been reported. In this study, we correlated cytogenetic abnormalities with clinical outcome in 97 T-PLL patients, including 66 men and 31 women with a median age of 63 years (range, 34-81). Twenty-seven patients had a normal karyotype (NK), one had two chromosomal aberrations, and 69 had a complex karyotype (CK)...
February 14, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28195443/a-higher-prevalence-of-hematologic-malignancies-in-patients-with-thalassemia-background-and-culprits
#18
Racha Halawi, Domenica Cappellini, Ali Taher
No abstract text is available yet for this article.
February 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28195442/genetic-modulation-of-fetal-hemoglobin-in-hydroxyurea-treated-sickle-cell-anemia
#19
LETTER
Milena Magalhães Aleluia, Rayra Pereira Santiago, Caroline Conceição da Guarda, Teresa Cristina Cardoso Fonseca, Fábia Idalina Neves, Regiana Souza Quinto, Camylla Villas Boas Figueiredo, Sètondji Cocou Modeste Alexandre Yahouédéhou, Rodrigo Mota Oliveira, Júnia Raquel Dutra Ferreira, Bruno Antônio Veloso Cerqueira, Cynara Gomes Barbosa, Jacqueline Nicole Milton, Martin H Steinberg, Marilda de Souza Gonçalves
No abstract text is available yet for this article.
February 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28195434/a-patient-with-both-methemoglobinemia-and-g6pd-deficiency-a-therapeutic-conundrum
#20
N Scott Reading, José A Ruiz-Bonilla, Robert D Christensen, William Cáceres-Perkins, Josef T Prchal
No abstract text is available yet for this article.
February 13, 2017: American Journal of Hematology
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