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Nuklearmedizin. Nuclear Medicine

Deni Hardiansyah, Wei Guo, Ali Asgar Attarwala, Peter Kletting, Felix M Mottaghy, Gerhard Glatting
AIM: To investigate the accuracy of treatment planning in peptide-receptor radionuclide therapy (PRRT) based on simulated PET data (using a PET noise model) and a physiologically based pharmacokinetic (PBPK) model. METHODS: The parameters of a PBPK model were fitted to the biokinetic data of 15 patients. True mathematical phantoms of patients (MPPs) were the PBPK model with the fitted parameters. PET measurements after bolus injection of 150 MBq (68)Ga-DOTATATE were simulated for the true MPPs...
November 25, 2016: Nuklearmedizin. Nuclear Medicine
Roswitha Runge, Jana Arlt, Liane Oehme, Robert Freudenberg, Jörg Kotzerke
AIM: Ionizing radiation produces DNA lesions among which DNA double strand breaks (DSB) are the most critical events. Radiation of various energy types might differ in their biological effectiveness. Here, we compared cell survival and DNA damage induced by (188)Re and X-rays using γH2AX foci as a measure of DSB. The correlation between survival and residual foci was also analyzed. METHODS: PCCl3 cells were irradiated with 200 kV X-rays (1.2 Gy/min) or 0.5-25 MBq/ml (188)Re (1 h irradiation) achieving doses up to 10 Gy...
October 26, 2016: Nuklearmedizin. Nuclear Medicine
Caroline Bouter, Isabell Braune, Birgit Meller, Carsten Sahlmann, Carsten Ritter, Johannes Meller
: The diagnostic strategy in patients with fever or inflammation of unknown origin remains a major clinical challenge. The aim of this study was to evaluate the role of 18F-FDG-PET/CT in patients with unexplained elevated C-reactive protein with or without fever. Contribution of 18F-FDG-PET/CT to the final diagnosis was evaluated. In addition we determined whether a differentiation between patients with or without fever is clinically reasonable. PATIENTS, METHODS: We retrospectively analyzed 72 consecutive patients with unexplained elevated C-reactive protein levels (above 8mg/l) that underwent 18F-FDG-PET/CT in our facility between 10/2009 and 11/2012...
September 12, 2016: Nuklearmedizin. Nuclear Medicine
Philipp Seifert, Veit König, Gunther O Hofmann, Martin Freesmeyer
No abstract text is available yet for this article.
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Daniela Chroustová, Marketa Bloomfield, Jiří Beneš, Jiří Trnka
No abstract text is available yet for this article.
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Guangying Wang, Yunyong Liu, Feng He
No abstract text is available yet for this article.
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Frederik A Verburg, Florian F Behrendt, Felix M Mottaghy, David Pfister, Florian Steib, Ruth Knuechel
No abstract text is available yet for this article.
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Rogier Lange, Floor Overbeek, John M H de Klerk, Pieternel C M Pasker-de Jong, Alexandra M van den Berk, Rob Ter Heine, Cees J Rodenburg, Anko Kooistra, N Harry Hendrikse, Haiko J Bloemendal
AIM: Rhenium-188-HEDP ((188)Re-HEDP) is an effective radiopharmaceutical for the palliative treatment of osteoblastic bone metastases. However, only limited data on its routine use are available and its effect on quality of life (QoL) has not been studied. Therefore, we evaluated the clinical benefit of (188)Re-HEDP in routine clinical care. PATIENTS AND METHODS: Prostate or breast cancer patients with painful bone metastases receiving (188)Re-HEDP as a routine clinical procedure were eligible for evaluation...
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Vesna Ilic, Vincent Dunet, Alain Le Pape, Mikael Buchs, Marek Kosinski, Angelika Bischof Delaloye, Stefan Gerber, John O Prior
AIMS: Vaccination by aerosol inhalation can be used to efficiently deliver antigen against HPV to mucosal tissue, which is particularly useful in developing countries (simplicity of administration, costs, no need for cold chain). For optimal immunological response, vaccine particles should preferentially be delivered to proximal bronchial airways. We aimed at quantifying the deposition of inhaled particles in central airways and peripheral lung, and to assess administration biosafety...
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Felix T Range, Peter Kies, Klaus P Schäfers, Günter Breithardt, Otmar Schober, Thomas Wichter, Michael A Schäfers
AIM: To investigate sex differences in myocardial perfusion especially in healthy individuals since former studies are rare and findings are controversial. Participants, methods: 26 subjects were enrolled: 16 healthy women (age: 34 ±7 years) were compared with 10 healthy men (age: 34 ± 3 years; p = ns). Myocardial blood flow (MBF) and coronary vascular resistance (CVR) were quantified at rest, during adenosine infusion and cold-pressor-testing, using positron emission tomography and radioactive-labelled water (H2(15)O-PET)...
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Thorsten D Pöppel, Michael Andreeff, Alexander Becherer, Andreas Bockisch, Eva Fricke, Lilli Geworski, Alexander Heinzel, Bernd J Krause, Thomas Krause, Markus Mitterhauser, Klemens Scheidhauer, Marcus Schenck, Wilfried Sonnenschein, Michael Gabriel
This document describes the guideline for therapy of bone metastases with radium-223 ((223)Ra) published by the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften in Germany (AWMF) under the auspices of the Deutsche Gesellschaft für Nuklearmedizin (DGN), Östereichische Gesellschaft für Nuklearmedizin (OGN), and Schweizerische Gesellschaft für Nuklearmedizin (SGNM). This guidance is based on an interdisciplinary consensus. These recommendations are a prerequisite for the quality management in the treatment of patients with bone metastases from prostate cancer using (223)Ra...
September 26, 2016: Nuklearmedizin. Nuclear Medicine
Harun Ilhan, Mona Mustafa, Peter Bartenstein, Torsten Kuwert, Daniela Schmidt
: SPECT/CT detects radioiodine-positive cervical lymph node metastases (LNMs) of differentiated thyroid carcinoma (DTC) at the time of postsurgical radioablation (RA). Preliminary evidence indicates that the majority of LNMs are successfully treated by RA. The aim of this study was to confirm this evidence in a bicentric setting and to evaluate whether size is a predictor for successful elimination. PATIENTS AND METHODS: Since 01/2007 and 05/2008, respectively, SPECT/spiral-CT is performed routinely in all patients with DTC at RA in two University Clinics...
September 2, 2016: Nuklearmedizin. Nuclear Medicine
Christian Happel, W Tilman Kranert, Benjamin Bockisch, Hüdayi Korkusuz, Frank Grünwald
: Germany has developed into a country with a nationwide largely sufficient iodine supply due to improved alimentary iodine supply. The reduction of iodine uptake in focal autonomies induced by reduced iodine avidity was evaluated by Gotthardt et al. 2006, showing a significant decline of pertechnetate uptake up to the year 2004. AIM: This study was intended to carry this investigation forward to the present day to analyze the course of a conjectural stabilization of iodine uptake values...
September 2, 2016: Nuklearmedizin. Nuclear Medicine
Philipp Genseke, Julian M M Rogasch, Ingo G Steffen, Grit Neumann, Ivayla Apostolova, Juri Ruf, Anke Rißmann, Dagobert Wiemann, Uwe-Bernd Liehr, Martin Schostak, Holger Amthauer, Christian Furth
AIM: After detection of obstructive uropathy (OU), the indication for or against surgery is primarily based on the differential renal function (DRF). This is to compare functional magnetic resonance urography (fMRU) with dynamic renal scintigraphy (DRS) to assess OU and DRF in infants and children. PATIENTS, METHODS: Retrospective analysis in 30 patients (female: 16; male: 14; median age: 5.5 years [0.2-16.5]), divided into subgroup A (age: 0-2 years; n = 16) and B (> 2-17 years; n = 14)...
August 29, 2016: Nuklearmedizin. Nuclear Medicine
Akram Al-Ibraheem, Maysa Al-Hussaini, Abedallatif AlSharif, Hazem Abdulelah
No abstract text is available yet for this article.
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Biao Li, Min Zhang, Jiabin Jin
No abstract text is available yet for this article.
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Mao-Chin Hung, Jeng-Jong Hwang
AIM: To investigate the trends in the utilization of nuclear medicine procedures and radiopharmaceuticals in an aging population and to establish the prediction models. METHODS: Based on Taiwan's National Health Insurance Research Database, a longitudinal study was conducted from 2000 to 2012. Descriptive statistics were adopted to analyze the frequencies and distributions of nuclear medicine procedures. Multiple linear regression analysis was applied to establish the prediction model for the utilization of nuclear medicine...
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Henryk Barthel, Philipp T Meyer, Alexander Drzezga, Peter Bartenstein, Henning Boecker, Peter Brust, Ralph Buchert, Heinz H Coenen, Christian la Fougère, Gerhard Gründer, Frank Grünwald, Bernd J Krause, Torsten Kuwert, Matthias Schreckenberger, Klaus Tatsch, Karl-Josef Langen, Osama Sabri
Recently, a number of positron emission tomography (PET) radiotracers have been approved for clinical use. These tracers target cerebral beta-amyloid (Aβ) plaques, a hallmark of Alzheimer's disease. Increasing use of this method implies the need for respective standards. This German Society of Nuclear Medicine guideline describes adequate procedures for Aβ plaque PET imaging. It not only discusses the tracers used for that purpose, but also lists measures for correct patient preparation, image data generation, processing, analysis and interpretation...
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Christian Schütze, Bernd O Knoop, Iris Vehrenkamp, Frank Rudolf, Lilli Geworski
UNLABELLED: Dose calibrators are one of the most important and most frequently used instruments for the determination of activities in nuclear medicine. For guaranteeing a constant quality of the dose calibrators' measurements, constancy checks including the examination of the system linearity have to be performed regularly, usually measured using 99mTc. The 99mTc eluate extracted from a 99Mo/99mTc generator is contaminated with molybdenum. Not accounting for the molybdenum impurity might lead to an exceed of the tolerance limit of 5% deviation to the reference value for this constancy check...
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Jens C Stollfuss, Lutz S Freudenberg, Hinrich Wieder
AIM: The precise localisation of osteoarthritic and inflammatory changes is crucial for selective treatment planning of radiosynovectomy (RSV). The present study evaluated the diagnostic accuracy of planar bone imaging and SPECT for the detection of pathological bone metabolism and inflammation in joints of the foot and ankle, compared with SPECT/CT. PATIENTS, METHODS: 39 patients (mean age 65.6 ± 11.1 years) with suspected inflammatory osteoarthritis underwent SPECT/CT of the feet...
August 5, 2016: Nuklearmedizin. Nuclear Medicine
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