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Nuklearmedizin. Nuclear Medicine

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https://www.readbyqxmd.com/read/28164207/incremental-value-of-99m-tc-hynic-toc-spect-ct-over-whole-body-planar-scintigraphy-and-spect-in-patients-with-neuroendocrine-tumours
#1
Mate Trogrlic, Stanko Težak
AIM: The aim of this study was to evaluate the additional value of (99m)Tc-HYNIC-TOC SPECT/CT over planar whole-body (WB) scintigraphy and SPECT alone in the detection and accurate localisation of neuroendocrine tumour (NET) lesions. METHODS: This study included 65 patients with a definitive histological diagnosis of NET prior to scintigraphy. Planar WB scintigraphy, SPECT, and SPECT/CT images were acquired at 4 h post-administration of 670 MBq (99m)Tc-HYNIC-TOC...
February 6, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28154879/-18-f-fdg-pet-ct-in-the-detection-of-asymptomatic-malignant-melanoma-recurrence
#2
Ismaheel Lawal, Thabo Lengana, Kehinde Ololade, Tebatso Boshomane, Florette Reyneke, Moshe Modiselle, Mariza Vorster, Mike Sathekge
AIM: To evaluate the diagnostic accuracy of FDG PET/CT in the detection of asymptomatic recurrence in patients with malignant melanoma who have had resection of their primary lesion. We also aimed to determine the pattern and factors predisposing to disease recurrence. METHODS: Patients with malignant melanoma who have had surgical resection of their disease and without any clinical evidence of disease recurrence were followed-up with FDG PET/CT. The diagnostic accuracy of FDG PET/CT, pattern of recurrence and factors predictive of disease recurrence were determined...
February 3, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28138688/twins-in-spirit-part-iv-177-lu-%C3%A2-high%C3%A2-affinity-dotatate-a-promising-new-tracer-for-peptide-receptor-radiotherapy
#3
Claudia Brogsitter, Holger Hartmann, Gerd Wunderlich, Margret Schottelius, Hans-Jürgen Wester, Jörg Kotzerke
AIM: Besides the use of somatostatin analogues, small molecules like sunitinib and everolimus as well as conventional chemotherapy, peptide receptor radiotherapy (PRRT) using radiolabelled somatostatin analogues has gained an important role in the treatment of inoperable, metastasized neuroendocrine tumours (NET). There are various radiotracers in use. Based on our experience with the PET tracer [(68)Ga]DOTA-3-iodo-Tyr(3)-octreotate ([(68)Ga]HA-DOTATATE), a DOTATATE derivative with an increased binding affinity to hsst5, the current retrospective analysis is exploring the therapeutic potential of [(177)Lu]HA-DOTATATE...
January 31, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28124062/prevalence-of-thyroid-disorders-in%C3%A2-elderly-people-in-germany-a-screening-study-in-a-country-with%C3%A2-endemic-goitre
#4
Frederik A Verburg, Inge Grelle, Kathrin Tatschner, Christoph Reiners, Markus Luster
AIM: In a screening study on people of working age the prevalence of morphological thyroid disorders was 33.1 %. It is not known precisely whether this further increases after retirement. The present study aimed to establish whether the increase in the prevalence of morphological and functional thyroid disorders continues beyond working age in elderly citizens. METHODS: 223 participants were recruited in an institute for geriatric rehabilitative medicine. All patients were screened by thyroid ultrasound, measurement of serum levels of thyroid hormones and thyroid related autoantibodies as well as measurement of urinary iodine excretion...
January 26, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28074210/diagnostic-value-of-additional-68-ga-psma-pet-before-223-ra-dichloride-therapy-in-patients-with-metastatic-prostate-carcinoma
#5
Axel Bräuer, Kambiz Rahbar, Julia Konnert, Martin Bögemann, Lars Stegger
PURPOSE: Medical imaging plays an important role in selecting patients with metastatic castration-resistant prostate cancer for (223)Ra-dichloride therapy of bone metastases. The purpose of this study was to investigate whether (68)Ga-PSMA-PET has incremental value over conventional imaging for selecting patients suitable for (223)Ra-dichloride therapy. METHODS: In 27 consecutive patients referred for (223)Ra-dichloride therapy additional (68)Ga-PSMA-PET/CT was performed and tracer distribution was evaluated systematically with respect to the detection of visceral metastases and bone metastases with inadequate uptake on bone scintigraphy...
January 11, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28004845/polymyalgia-rheumatica-detected-by-spect-ct-using-99m-tc-labeled-monoclonal-antibody-fab-fragments
#6
Anne Frölich, Ilka Schwarze, Christoph Neumann
No abstract text is available yet for this article.
December 22, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27909712/myocardial-perfusion-spect-2015-in-germany-results-of-the-7th-survey
#7
Oliver Lindner, Wolfgang Burchert, Wolfgang Schäfer, Marcus Hacker
AIM: The working group Cardiovascular Nuclear Medicine of the German Society of Nuclear Medicine presents the results of the 7th survey of myocardial perfusion SPECT (MPS) of the reporting year 2015. METHOD: 268 questionnaires (173 practices [PR], 67 hospitals [HO], 28 university hospitals [UH]) were evaluated. Results of the last survey from 2012 are set in squared brackets. RESULTS: MPS of 121 939 [105 941] patients were reported. 98 % [95 %] of all MPS were performed with Tc-99m radiopharmaceuticals and 2 % [5 %] with Tl-201...
December 2, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27885372/treatment-planning-in-prrt-based-on-simulated-pet-data-and-a-pbpk-model-determination-of-accuracy-using-a-pet-noise-model
#8
Deni Hardiansyah, Wei Guo, Ali Asgar Attarwala, Peter Kletting, Felix M Mottaghy, Gerhard Glatting
AIM: To investigate the accuracy of treatment planning in peptide-receptor radionuclide therapy (PRRT) based on simulated PET data (using a PET noise model) and a physiologically based pharmacokinetic (PBPK) model. METHODS: The parameters of a PBPK model were fitted to the biokinetic data of 15 patients. True mathematical phantoms of patients (MPPs) were the PBPK model with the fitted parameters. PET measurements after bolus injection of 150 MBq (68)Ga-DOTATATE were simulated for the true MPPs...
November 25, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922156/erratum-to-li-b-zhang-m-jin-j-unusual-fdg-uptakes-of-mesenteric-brown-adipose-tissue-in-a-patient-with-pheochromocytomas-nuklearmedizin-2016-55-n32-n33
#9
(no author information available yet)
No abstract text is available yet for this article.
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922155/metastatic-epithelioid-sarcoma-revealed-with-18-f-fdg%C3%A2-pet-ct-imaging
#10
Burcu Dirlik Serim, Betul Vatankulu, Metin Halaç, Suleyman Dikici, Fatih Kantarcı, Kerim Sönmezoğlu
No abstract text is available yet for this article.
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922154/-der-hoch-normale-ft4-spiegel-ist-mit-vorhofflimmern-assoziiert-neue-daten-erg%C3%A3-nzen-die-dgn-handlungsempfehlung-zur-radioiodtherapie
#11
Markus Dietlein, Alexander Drzezga
No abstract text is available yet for this article.
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922153/-radioiodine-therapy-for-benign-thyroid-diseases-version-5-german-guideline
#12
Markus Dietlein, Frank Grünwald, Matthias Schmidt, Peter Schneider, Frederik A Verburg, Markus Luster
The version 5 of the guideline for radioiodine therapy of benign thyroid disorders is an update of the version 4, which was published by the German Society of Nuclear Medicine (Deutsche Gesellschaft für Nuklearmedizin, DGN) in co-ordination with the German Society of Endocrinology (Deutsche Gesellschaft für Endokrinologie, DGE, Sektion Schilddrüse) and the German Society of General- and Visceral-Surgery (Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie, DGAV) in 2007. This guideline was harmonized with the recommendations of the European Association of Nuclear Medicine (EANM)...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922152/diagnosis-of-chronic-osteomyelitis-by-combined-99m-tc-bone-and-99m-tc-anti-granulocyte-scintigraphy
#13
Anne Frölich, Gotthard Knoll, Manfred Bähre, Christoph Neumann
No abstract text is available yet for this article.
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27922151/-68-ga-psma-hbed-cc-pet-ct-to-differentiate-between-diffuse-bone-metastases-of-prostate-cancer-and-osteopoikilosis
#14
Florian Behrendt, Thomas Krohn, Felix Mottaghy, Frederik A Verburg
No abstract text is available yet for this article.
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27617327/-18-f-fdg-pet-ct-in-unexplained-elevated-inflammatory-markers-joining-entities
#15
Caroline Bouter, Isabell Braune, Birgit Meller, Carsten Sahlmann, Carsten Ritter, Johannes Meller
: The diagnostic strategy in patients with fever or inflammation of unknown origin remains a major clinical challenge. The aim of this study was to evaluate the role of (18)F-FDG-PET/CT in patients with unexplained elevated C-reactive protein with or without fever. Contribution of (18)F-FDG-PET/CT to the final diagnosis was evaluated. In addition we determined whether a differentiation between patients with or without fever is clinically reasonable. PATIENTS, METHODS: We retrospectively analysed 72 consecutive patients with unexplained elevated C-reactive protein levels (above 8mg/l) that underwent (18)F-FDG-PET/CT in our facility between 10/2009 and 11/2012...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27588323/rate-of-elimination-of-radioiodine-avid-lymph-node-metastases-of-differentiated-thyroid-carcinoma-by-postsurgical-radioiodine-ablation-a-bicentric-study
#16
Harun Ilhan, Mona Mustafa, Peter Bartenstein, Torsten Kuwert, Daniela Schmidt
: SPECT/CT detects radioiodine-positive cervical lymph node metastases (LNMs) of differentiated thyroid carcinoma (DTC) at the time of postsurgical radioablation (RA). Preliminary evidence indicates that the majority of LNMs are successfully treated by RA. The aim of this study was to confirm this evidence in a bicentric setting and to evaluate whether size is a predictor for successful elimination. PATIENTS AND METHODS: Since 01/2007 and 05/2008, respectively, SPECT/spiral-CT is performed routinely in all patients with DTC at RA in two University Clinics...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27585492/-131-i-and-99m-tc-uptake-in-focal-thyroid-autonomies-development-in-germany-since-the-1980s
#17
Christian Happel, W Tilman Kranert, Benjamin Bockisch, Hüdayi Korkusuz, Frank Grünwald
: Germany has developed into a country with a nationwide largely sufficient iodine supply due to improved alimentary iodine supply. The reduction of iodine uptake in focal autonomies induced by reduced iodine avidity was evaluated by Gotthardt et al. 2006, showing a significant decline of pertechnetate uptake up to the year 2004. AIM: This study was intended to carry this investigation forward to the present day to analyze the course of a conjectural stabilization of iodine uptake values...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27480576/recombinant-human-thyrotropin-stimulated-131-i-treatment-for-multinodular-goiter
#18
Limin Tang, Tiekun Ma, Fengyu Wu
: The aim of the study was to investigate the effects of rhTSH stimulation before (131)I treatment in patients with MNG. METHODS: Sources included the Cochrane Library, MEDLINE, EMBASE, and SCOPUS database (all until January 2016). Randomized controlled trials (RCTs) that assessed the efficacy of rhTSH-stimulated (131)I treatment compared to placebo or (131)I treatment alone were collected. Two authors performed the data extraction independently. RESULTS: Six RCTs involving 294 patients with MNG were included in this review...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27781237/comparison-of-clonogenic-cell-survival-and-dna-damage-induced-by-188-re-and-x-rays-in-rat-thyroid-cells
#19
Roswitha Runge, Jana Arlt, Liane Oehme, Robert Freudenberg, Jörg Kotzerke
AIM: Ionizing radiation produces DNA lesions among which DNA double strand breaks (DSB) are the most critical events. Radiation of various energy types might differ in their biological effectiveness. Here, we compared cell survival and DNA damage induced by (188)Re and X-rays using γH2AX foci as a measure of DSB. The correlation between survival and residual foci was also analyzed. METHODS: PCCl3 cells were irradiated with 200 kV X-rays (1.2 Gy/min) or 0.5-25 MBq/ml (188)Re (1 h irradiation) achieving doses up to 10 Gy...
October 26, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27668302/devitalized-bone-in-a-multi-fragment-femoral-shaft-fracture-detected-by-18-f-naf-pet-ct
#20
Philipp Seifert, Veit König, Gunther O Hofmann, Martin Freesmeyer
No abstract text is available yet for this article.
September 26, 2016: Nuklearmedizin. Nuclear Medicine
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