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Thrombosis and Haemostasis

Ethan D Borre, Adam Goode, Giselle Raitz, Bimal Shah, Angela Lowenstern, Ranee Chatterjee, Lauren Sharan, Nancy M Allen LaPointe, Roshini Yapa, J Kelly Davis, Kathryn Lallinger, Robyn Schmidt, Andrzej Kosinski, Sana M Al-Khatib, Gillian D Sanders
BACKGROUND:  Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of stroke. Medical therapy for decreasing stroke risk involves anticoagulation, which may increase bleeding risk for certain patients. In determining the optimal therapy for stroke prevention for patients with AF, clinicians use tools with various clinical, imaging and patient characteristics to weigh stroke risk against therapy-associated bleeding risk. AIM:  This article reviews published literature and summarizes available risk stratification tools for stroke and bleeding prediction in patients with AF...
October 30, 2018: Thrombosis and Haemostasis
Susan A Maroney, Julie A Peterson, Wes Zwifelhofer, Nicholas D Martinez, Ke Yan, Niebler Ra, E Stuth, J P Scott, Rachel S Bercovitz, Ronald K Woods, Alan E Mast
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
Derek Weycker, Xiaoyan Li, Gail DeVecchis Wygant, Theodore Lee, Melissa Hamilton, Xuemei Luo, Lien Vo, Jack Mardekian, Xianying Pan, Leah Burns, Mark Atwood, Ahuva Hanau, Alexander T Cohen
In the AMPLIFY clinical trial, apixaban was non-inferior to warfarin plus subcutaneous enoxaparin bridge therapy in the treatment of acute venous thromboembolism (VTE) and was associated with significantly less bleeding. This study evaluated their comparative effectiveness and safety in routine clinical practice. A matched-cohort design and data from four U.S. private health care claims databases were employed. Study population comprised patients who initiated outpatient treatment with apixaban versus warfarin (plus parenteral anticoagulant bridge therapy) within 30 days of their initial VTE episode; apixaban and warfarin patients were matched on age, characteristics of VTE episode, study database and propensity score...
November 2018: Thrombosis and Haemostasis
Sebastian Göbel, Jürgen H Prochaska, Lisa Eggebrecht, Ronja Schmitz, Claus Jünger, Heidrun Lamparter, Markus Nagler, Karsten Keller, Meike Coldewey, Sven-Oliver Tröbs, Simon Diestelmeier, Sören Schwuchow-Thonke, Christoph Bickel, Michael Lauterbach, Karl J Lackner, Hugo Ten Cate, Thomas Münzel, Roland Hardt, Philipp S Wild
Patients with heart failure (HF) are frequently anti-coagulated with vitamin K-antagonists (VKAs). The use of long-acting VKA may be preferable for HF patients due to higher stability of plasma concentrations. However, evidence on phenprocoumon-based oral anti-coagulation (OAC) therapy in HF is scarce. The aim of this study was to assess the impact of the presence of HF on quality of phenprocoumon-based OAC and the subsequent clinical outcome. Quality of OAC therapy and the incidence of adverse events were analysed in a cohort of regular care ( n  = 2,011) from the multi-centre thrombEVAL study program (NCT01809015) stratified by the presence of HF...
November 2018: Thrombosis and Haemostasis
Vânia M Morelli, Willem M Lijfering, Suely M Rezende, Astrid van Hylckama Vlieg, Frits R Rosendaal, Suzanne C Cannegieter
BACKGROUND:  Kidney function, measured as estimated glomerular filtration rate (eGFR), glucose levels and haematologic variables (blood cell count) are easily obtainable tests, and have been associated with increased risk of first venous thrombosis (VT). Whether these routine tests can identify patients at risk of recurrence is unclear. AIM:  Our aim was to investigate the predictive value of serum glucose levels, eGFR and haematologic variables in patients at risk of recurrent VT...
November 2018: Thrombosis and Haemostasis
Lina Badimon
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
Manuel Monreal
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
Alessandro Casini, Marc Blondon, Veronique Tintillier, Matthew Goodyer, Melike E Sezgin, Adalet M Gunes, Michel Hanss, Philippe de Moerloose, Marguerite Neerman-Arbez
BACKGROUND:  Numerous mutations in FGA , FGB or FGG lead to congenital fibrinogen disorders (CFDs), but their epidemiology is not well characterized. The aim of this study was to evaluate the molecular epidemiology of CFD and to develop a genotyping strategy. METHODS:  Genetic data from 266 unrelated CFD patients genotyped at our laboratory and from a CFD open access database ( n  = 1,142) were evaluated. We developed a step-wise screening strategy for the molecular diagnosis of CFD and prospectively tested this strategy on 32 consecutive CFD probands...
November 2018: Thrombosis and Haemostasis
Paul C Kruger, Jack Hirsh, Vinai C Bhagirath, Ke Xu, Brian Dale, Tim A C de Vries, Jeffrey S Ginsberg, John W Eikelboom, Noel C Chan
BACKGROUND:  Ticagrelor is an anti-platelet agent that is indicated for prevention of thrombosis after acute coronary syndrome or intra-coronary artery stent implantation, but it increases the risk of bleeding. Platelet transfusion has the potential to treat or prevent bleeding in patients taking ticagrelor, but the optimal quantity of platelets and timing of administration have not been fully defined. METHODS AND RESULTS:  Ten healthy subjects took ticagrelor in combination with acetylsalicylic acid for 5 days, and had blood collected prior to treatment and at 2, 10, 24, 48, 72 and 96 hours after the last doses...
November 2018: Thrombosis and Haemostasis
Peter Mirtschink, Triantafyllos Chavakis
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
Majed A Refaai, Paul Riley, Tatsiana Mardovina, Phoenix D Bell
INTRODUCTION:  Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition...
November 2018: Thrombosis and Haemostasis
Daniele Pastori, Francesco Violi
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
Bérangère S Joly, Pierre Boisseau, Elien Roose, Alain Stepanian, Nathalie Biebuyck, Julien Hogan, François Provot, Yahsou Delmas, Céline Garrec, Karen Vanhoorelbeke, Paul Coppo, Agnès Veyradier
BACKGROUND:  Congenital thrombotic thrombocytopaenic purpura (TTP) or Upshaw-Schulman syndrome (USS) is a rare, life-threatening, inherited thrombotic microangiopathy (TMA). USS is mostly due to bi-allelic recessive sequence variations of the a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13 ( ADAMTS13 ) gene inducing a severe ADAMTS13 deficiency (activity < 10 IU/dL). In healthy individuals, ADAMTS13 circulates in a folded conformation where CUB domains interact with the spacer domain...
November 2018: Thrombosis and Haemostasis
Sabato Sorrentino, Usman Baber, Bimmer E Claessen, Anton Camaj, Birgit Vogel, Samantha Sartori, Paul Guedeney, Jaya Chandrasekhar, Serdar Farhan, Nitin Barman, Joseph Sweeny, Gennaro Giustino, George Dangas, Annapoorna Kini, Samin Sharma, Roxana Mehran
BACKGROUND:  Although several variables have been identified as bleeding determinants (BDs), their occurrence and predictive value in patients undergoing percutaneous coronary intervention (PCI) in the real world remain unclear. We aimed to characterize the rate of BDs in patients undergoing PCI with stent implantation in a large volume tertiary centre. METHODS:  We included patients undergoing coronary stenting at our institution from January 2012 to December 2016, and defined post-discharge bleeding (PDB) as bleeding requiring hospitalization or transfusion...
November 2018: Thrombosis and Haemostasis
Yuqian Feng, Miao Yu, Feng Zhu, Shaoshao Zhang, Peiwu Ding, Min Wang
The development of deep venous thrombosis (DVT) is a sterile inflammatory process related to cytokines, such as interleukin (IL)-6 or IL-17. IL-9 is a cytokine involved in many inflammatory diseases, including cystic fibrosis, ulcerative colitis, psoriasis and psoriatic arthritis. However, it remains unknown whether IL-9 is related to DVT. In this study, we characterized the role and mechanism of IL-9 in DVT. Analysis of the data of patients with and without DVT revealed that stasis, venous surgery as well as elevated IL-9 and sP-selectin levels were related to the development of DVT...
November 2018: Thrombosis and Haemostasis
Marina Loguinova, Natalia Pinegina, Valeria Kogan, Murad Vagida, Anush Arakelyan, Alexander Shpektor, Leonid Margolis, Elena Vasilieva
Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte-platelet complexes (MPCs). Here, we analysed MPC in vivo and in vitro and investigated the abilities of different monocyte subclasses to form MPC, the characteristics of the cells involved in MPC formation and MPC changes in AMI. We identified MPC by co-staining for platelet antigen CD41a and monocyte antigens CD14 and CD16. Platelet activation was evaluated from expression of phosphatidylserine as revealed by annexin V...
November 2018: Thrombosis and Haemostasis
Chih-Yao Chiang, Chen-Yen Chien, Wei-Yin Qiou, Christopher Chang, I-Shing Yu, Po-Yuan Chang, Chiang-Ting Chien
OBJECTIVE:  Activation of thromboxane A2 synthase (TXAS)/thromboxane A2 (TXA2 )/thromboxane prostanoid (TP) receptor leads to arterial constriction, platelet aggregation and vascular injury. We attempted to characterize the microvascular dysfunction in ischaemia/reperfusion injury using genetically modified TXAS-/- , TP-/- and TXAS-/- TP-/- mice. APPROACH AND RESULTS:  The cardiac micro-circulation and electrocardiograms were evaluated from B6, TXAS-/- , TP-/- and TXAS-/- TP-/- mice in response to intravenous saline, endothelin-1, U46619 (a TXA2 agonist) and myocardial ischaemia/reperfusion injury...
November 2018: Thrombosis and Haemostasis
Nicholas S Roetker, Richard F MacLehose, Ron C Hoogeveen, Christie M Ballantyne, Saonli Basu, Mary Cushman, Aaron R Folsom
Exogenous hormone treatments in women (oral contraceptives and hormone replacement therapy [HRT]) are established risk factors for venous thromboembolism (VTE), but less is known about associations between plasma levels of endogenous hormones and VTE risk. We examined the association of baseline dehydroepiandrosterone sulphate (DHEAS), testosterone and sex hormone-binding globulin (SHBG) with risk of future VTE in men and post-menopausal women in the Atherosclerosis Risk in Communities Study. Testosterone, DHEAS and SHBG were measured in plasma samples collected in 1996 to 1998...
November 2018: Thrombosis and Haemostasis
Elvira Grandone, Pier Paolo Di Micco, Michela Villani, Donatella Colaizzo, Carmen Fernández-Capitán, Jorge Del Toro, Vladimir Rosa, Alessandra Bura-Riviere, Isabelle Quere, Ángeles Blanco-Molina, Maurizio Margaglione, Manuel Monreal
Venous thromboembolism (VTE) during or after assisted reproductive technologies (ART) is predicted to rise due to the increased number of women undergoing this technique. We present data collected in the RIETE registry up to October 2016. Overall, 41 (0.6%) out of 6,718 women of childbearing age with VTE had an ART-related event. Most of them underwent autologous ART cycles; 23 had isolated deep vein thrombosis (DVT) (56.1%), 12 isolated pulmonary embolism (PE) (29.3%) and 6 simultaneous occurrence of both the events (14...
November 2018: Thrombosis and Haemostasis
Sylvie Bouvier, Mathias Chea, Sylvie Ripart, Michel Hanss, Philippe de Mazancourt, Jean-Christophe Gris
No abstract text is available yet for this article.
November 2018: Thrombosis and Haemostasis
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