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Thrombosis and Haemostasis

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https://www.readbyqxmd.com/read/29723875/dynamic-changes-of-cha2ds2-vasc-score-and-the-risk-of-ischaemic-stroke-in-asian-patients-with-atrial-fibrillation-a-nationwide-cohort-study
#1
Minjae Yoon, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung
BACKGROUND:  Stroke risk in atrial fibrillation (AF) is often assessed at initial presentation, and risk stratification performed as a 'one off'. In validation studies of risk prediction, baseline values are often used to 'predict' events that occur many years later. Many clinical variables have 'dynamic' changes over time, as the patient is followed up. These dynamic changes in risk factors may increase the CHA2 DS2 -VASc score, stroke risk category and absolute ischaemic stroke rate...
May 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29723874/peri-operative-adverse-outcomes-in-patients-with-atrial-fibrillation-taking-warfarin-or-edoxaban-analysis-of-the-engage-af-timi-48-trial
#2
James D Douketis, Sabina A Murphy, Elliott M Antman, Laura T Grip, Michele F Mercuri, Christian T Ruff, Jeffrey I Weitz, Eugene Braunwald, Robert P Giugliano
BACKGROUND:  Peri-operative management of anticoagulated patients with atrial fibrillation (AF) is challenging. To gain information on the peri-operative management of edoxaban, we compared outcomes in patients on warfarin or edoxaban enrolled in ENGAGE AF-TIMI 48 who underwent a surgery or invasive procedure. METHODS:  Data from patients undergoing their first surgery/procedure were analysed and results compared by anticoagulant (warfarin vs. higher- or lower-dose edoxaban regimen [HDER and LDER, respectively])...
May 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29723873/antibodies-against-hdl-components-in-ischaemic-stroke-and-coronary-artery-disease
#3
Joana R Batuca, Marta C Amaral, Catarina Favas, Gonçalo C Justino, Ana L Papoila, Paul R J Ames, José Delgado Alves
Quantitative and qualitative defects of high-density lipoprotein (HDL) are important in atherogenesis. In this study, we investigated whether antibodies against HDL components had additional value to conventional cardiovascular risk factors for the diagnosis of ischaemic stroke (IS) and coronary artery disease (CAD). Cross-sectional study was conducted on 53 patients with IS, 51 with CAD and 55 healthy controls, and in vitro studies to validate findings of the clinical study. We determined serum immunoglobulin G (IgG) antibodies against HDL (aHDL), apolipoproteins (aApoA-I, aApoA-II and aApoC-I) and paraoxonase-1 (aPON1) as well as PON1 activity (PON1a), total antioxidant capacity and biomarkers of endothelial activation (serum nitric oxide metabolites, 3-nitrotyrosine, VCAM-1 and ICAM-1); in vitro assays tested the capacity of IgG aHDL purified from high titer patients to inhibit PON1a and to reverse protective effect of HDL on endothelial cells...
May 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29702713/predictors-of-bleeding-in-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-using-the-health-improvement-network-in-the-united-kingdom
#4
Lucía Cea Soriano, F Gerry R Fowkes, Alaster M Allum, Saga Johansson, Luis A García Rodriguez
The purpose of this analysis was to assess potential predictors of intra-cranial bleeding (ICB) and gastrointestinal bleeding (GIB) in patients with symptomatic peripheral artery disease (PAD) in UK primary care. Patients with symptomatic PAD diagnosed from 2000 to 2010 were identified from The Health Improvement Network (THIN; N  = 28,484). A nested case-control analysis, adjusted for potential confounders, was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for potential predictors of ICB or GIB...
April 27, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29695023/the-performance-of-ct-versus-mri-in-the-differential-diagnosis-of-cerebral-venous-thrombosis
#5
Weilin Xu, Liansheng Gao, Tao Li, Neha Darshana Ramdoyal, Jianmin Zhang, Anwen Shao
BACKGROUND:  Cerebral venous thrombosis (CVT) is a rare disease, and with poor prognosis. Computed tomography (CT) and magnetic resonance imaging (MRI) are the most commonly used image modalities for patients with non-specific neurologic symptoms. We present here a meta-analysis to assess the accuracy of CT and MRI in the differential diagnosis of CVT and cerebral venous sinus thrombosis (CVST). MATERIALS AND METHODS:  A comprehensive search of the PubMed, EMBASE, Web of Science, Cochrane Database and Chinese Biomedical (CBM) databases was conducted prior to March 20, 2017...
April 25, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29695022/catheter-related-arterial-thrombosis-in-neonates-and-children-a-systematic-review
#6
Mattia Rizzi, Neil Goldenberg, Mariana Bonduel, Shoshana Revel-Vilk, Ernest Amankwah, Manuela Albisetti
Catheter-related arterial thrombosis (CAT) is increasingly recognized in children. Available data are scarce and based on expert opinions. This systematic review aimed to identify knowledge on paediatric CAT. Among 3,484 publications, 22 met inclusion criteria. Fourteen reported on CAT due to umbilical arterial catheter (UAC), two to extremity indwelling catheter (EIC), one to both and five to cardiac catheter (CC). The overall cumulative incidence of CAT was 21% (95% confidence interval [CI], 13-31) with a relative incidence of 20% (95% CI, 10-33) for UAC and 11% (95% CI, 3-21) for CC-related CAT...
April 25, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29695021/pre-clinical-model-to-study-recurrent-venous-thrombosis-in-the-inferior-vena-cava
#7
Elizabeth A Andraska, Catherine E Luke, Megan A Elfline, Samuel P Henke, Siddharth S Madapoosi, Allan K Metz, Megan E Hoinville, Thomas W Wakefield, Peter K Henke, Jose A Diaz
BACKGROUND:  Patients undergoing deep vein thrombosis (VT) have over 30% recurrence, directly increasing their risk of post-thrombotic syndrome. Current murine models of inferior vena cava (IVC) VT model host one thrombosis event. OBJECTIVE:  We aimed to develop a murine model to study IVC recurrent VT in mice. MATERIALS AND METHODS:  An initial VT was induced using the electrolytic IVC model (EIM) with constant blood flow. This approach takes advantage of the restored vein lumen 21 days after a single VT event in the EIM demonstrated by ultrasound...
April 25, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29695020/significant-hypo-responsiveness-to-gpvi-and-clec-2-agonists-in-pre-term-and-full-term-neonatal-platelets-and-following-immune-thrombocytopenia
#8
Alexander T Hardy, Verónica Palma-Barqueros, Stephanie K Watson, Jean-Daniel Malcor, Johannes A Eble, Elizabeth E Gardiner, José E Blanco, Rafael Guijarro-Campillo, Juan L Delgado, María L Lozano, Raúl Teruel-Montoya, Vicente Vicente, Steve P Watson, José Rivera, Francisca Ferrer-Marín
Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type lectin-like receptor 2 (CLEC-2). GPVI and CLEC-2 activate a Src- and Syk-dependent signalling pathway upstream of phospholipase C (PLC) γ2. Phosphorylation of a conserved YxxL sequence known as a (hemi) immunotyrosine-based-activation-motif (ITAM) in both receptors is critical for Syk activation...
April 25, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29679949/lines-of-zahn-in-the-splenic-vein
#9
Armin Rashidi, Scott Gilles, Michael A Linden
No abstract text is available yet for this article.
April 21, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29679948/clinical-course-of-venous-thromboembolism-in-patients-with-pancreatic-cancer-insights-from-the-riete-registry
#10
Corinne Frere, Javier Trujillo-Santos, Carme Font, Ángel Sampériz, Roberto Quintavalla, José González-Martínez, Fernando Javier Vázquez, Jorge Lima, Dominique Farge, Manuel Monreal
No abstract text is available yet for this article.
April 21, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29679947/tissue-factor-coagulant-activity-is-regulated-by-the-plasma-membrane-microenvironment
#11
Yuanjie Yu, Anita N Böing, Chi M Hau, Najat Hajji, Wolfram Ruf, Auguste Sturk, Rienk Nieuwland
BACKGROUND:  Tissue factor (TF) can be present in a non-coagulant and coagulant form. Whether the coagulant activity is affected by the plasma membrane microenvironment is unexplored. OBJECTIVE:  This article studies the presence and coagulant activity of human TF in plasma membrane micro-domains. METHODS:  Plasma membranes were isolated from human MIA PaCa2 cells, MDA-MB-231 cells and human vascular smooth muscle cells by Percoll gradient ultracentrifugation after cell disruption...
April 21, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#12
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29669388/endothelial-autophagy-does-not-influence-venous-thrombosis-in-mice
#13
Pierre-Emmanuel Rautou, Johanna Busse, Marouane Kheloufi, Anne-Clémence Vion, Yacine Boulaftali, Konstantin Stark, Chantal M Boulanger
No abstract text is available yet for this article.
April 18, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29669387/evidence-that-mrp4-is-only-partly-involved-in-s1p-secretion-during-platelet-activation
#14
Benoit Decouture, Pierre-Hadrien Becker, Patrice Therond, Pascale Gaussem, Christilla Bachelot-Loza
No abstract text is available yet for this article.
April 18, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29669386/the-essential-ectoenzyme-smnpp5-from-the-human-intravascular-parasite-schistosoma-mansoni-is-an-adpase-and-a-potent-inhibitor-of-platelet-aggregation
#15
Manal Elzoheiry, Akram A Da'dara, Armelle M deLaforcade, Samar N El-Beshbishi, Patrick J Skelly
Schistosomes are intravascular parasitic platyhelminthes infecting > 200 million people globally and causing a debilitating disease, schistosomiasis. Despite the relatively large size of the adult worms and their disruption of blood flow, surprisingly, they do not appear to provoke thrombus formation around them in vivo. We hypothesize that proteins expressed at the host-parasite interface are key to this ability. Here, we functionally express an ectonucleotide pyrophosphatase/phosphodiesterase homologue, SmNPP5, that is expressed at the tegumental surface of intravascular Schistosoma mansoni ...
April 18, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29669385/apolipoprotein-m-protects-lipopolysaccharide-treated-mice-from-death-and-organ-injury
#16
Makoto Kurano, Koichi Tsuneyama, Yuki Morimoto, Tomo Shimizu, Masahiro Jona, Hidetoshi Kassai, Kazuki Nakao, Atsu Aiba, Yutaka Yatomi
OBJECTIVE:  High-density lipoprotein (HDL) has been epidemiologically shown to be associated with the outcome of sepsis. One potential mechanism is that HDL possesses pleiotropic effects, such as anti-apoptosis, some of which can be ascribed to sphingosine 1-phosphate (S1P) carried on HDL via apolipoprotein M (apoM). Therefore, the aim of this study was to elucidate the roles of apoM/S1P in the consequent lethal conditions of sepsis, such as multiple organ failure caused by severe inflammation and/or disseminated intravascular coagulation...
April 18, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29625499/optimizing-vitamin-k-antagonist-treatment-in-patients-with-mechanical-heart-valve-prosthesis
#17
Vanessa Roldán, Francisco Marín
No abstract text is available yet for this article.
April 6, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29625498/platelet-inhibition-and-bleeding-in-patients-undergoing-non-cardiac-surgery-the-bianca-observational-study
#18
Elisabeth Mahla, Helfried Metzler, Helmar Bornemann-Cimenti, Florian Prueller, Reinhard B Raggam, Gudrun Pregartner, Andrea Berghold, Anneliese Baumann, Christian Goeroeg, Paul A Gurbel
Nearly 20% of patients will need non-cardiac surgery within 1 year of coronary stenting and their management is complicated by concomitant antiplatelet therapy. Platelet function testing may optimize the timing of surgery in these patients. In this prospective observational study, we explored the association between platelet reactivity and bleeding in patients undergoing non-cardiac surgery treated with clopidogrel with or without aspirin within 7 days before surgery. The timing of surgery was at the surgeon's discretion...
April 6, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29618162/renal-impairment-recurrent-venous-thromboembolism-and-bleeding-in-cancer-patients-with-acute-venous-thromboembolism-analysis-of-the-catch-study
#19
Rupert Bauersachs, Agnes Y Y Lee, Pieter W Kamphuisen, Guy Meyer, Mette S Janas, Mikala F Jarner, Alok A Khorana
OBJECTIVE:  This article assesses the impact of renal impairment (RI) on the efficacy and safety of anticoagulation in patients with cancer-associated thrombosis from the Comparison of Acute Treatments in Cancer Hemostasis (CATCH) study (NCT01130025). MATERIALS AND METHODS:  Renal function was assessed using the Modification of Diet in Renal Disease equation in patients with cancer-associated thrombosis who received either tinzaparin (175 IU/kg) once daily or warfarin for 6 months, in an open-label, randomized, multi-centre trial with blinded adjudication of outcomes...
April 4, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29618161/risk-of-thromboembolic-events-without-oral-anticoagulation-at-90-days-after-surgical-aortic-valve-replacement-with-a-bioprosthesis
#20
Thierry Bourguignon, Anne Bernard, Laurent Fauchier
No abstract text is available yet for this article.
April 4, 2018: Thrombosis and Haemostasis
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