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Thrombosis and Haemostasis

Alexander T Cohen, Giancarlo Agnelli, Harry R Buller, Alexander Gallus, Gary E Raskob, Paul Sanders, John Thompson, Jeffrey I Weitz
The double-blind, randomized, AMPLIFY trial compared 6 months' treatment with apixaban (10 mg twice daily for 7 days and 5 mg twice daily thereafter) versus conventional treatment (subcutaneous enoxaparin [1 mg/kg twice daily for ≥ 5 days] overlapped and followed by warfarin [international normalized ratio = 2.0-3.0]) in patients with acute venous thromboembolism (VTE). This post hoc analysis of AMPLIFY compared outcomes among those taking or not taking concomitant anti-platelet therapy. The primary efficacy outcome was recurrent VTE or VTE-related death; the principal safety outcome was major bleeding...
January 16, 2019: Thrombosis and Haemostasis
Lynn M Knowles, Daniela Kagiri, Martin Bernard, Eva C Schwarz, Hermann Eichler, Jan Pilch
Macrophages make important contributions to inflammation and wound healing. We show here that macrophage polarization is deregulated in haemophilia in response to macrophage colony-stimulating factor (M-CSF) and partially in response to granulocyte-macrophage colony-stimulating factor (GM-CSF). As a result, haemophilia macrophages exhibit a specific impairment of M-CSF-mediated functions involved in wound healing such as clot invasion and phagocytosis. Haemophilia monocytes express reduced amounts of the receptors for M-CSF and GM-CSF, which correlates with a failure to express tumour necrosis factor α (TNFα) and CD163 in M-CSF-treated haemophilia macrophages and reduced expression of TNFα and CD206 after treatment with GM-CSF...
January 16, 2019: Thrombosis and Haemostasis
Ziane Elaïb, Jose Javier Lopez, Muriel Coupaye, Kevin Zuber, Yann Becker, Aurélie Kondratieff, Christelle Repérant, Marion Pépin, Laurence Salomon, France Teillet, Simon Msika, Cécile V Denis, Dominique de Prost, Jean-Philippe Rosa, Régis Bobe, Alain Stépanian
In obesity, platelets are described as hyperactive, mainly based on increased platelet size and presence of pro-thrombotic plasmatic molecules. We explored platelet functions, including calcium signalling in obesity, and the effect of weight loss. We included 40 obese patients (women with body mass index [BMI] of ≥ 35 kg/m2 ) who were to undergo gastric bypass surgery and 40 healthy lean subjects (women with BMI of < 25 kg/m2 ) as a control group. Approximately 1 year after surgery, the obese patients lost weight (75% had a BMI < 35 kg/m2 )...
January 16, 2019: Thrombosis and Haemostasis
Xin Li, Shu-Wen Wang, Qi Feng, Yu Hou, Nan Lu, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng
Immune thrombocytopaenia (ITP) is the most common autoimmune bleeding disorder, where platelets are destroyed by auto-antibodies and/or cell-mediated mechanisms. To understand the pathogenesis of ITP and explore novel therapeutics, three types of animal models have been used: passive ITP, secondary ITP and platelet-induced ITP. However, the first two are not ideal for chronic ITP pathophysiology where both T cell and B cell play important roles in platelet destruction. The most efficient model to mimic chronic ITP is developed by Chow et al through transferring splenocytes from platelet-immune CD61-knockout (KO) mice into mice with severe combined immunodeficiency (SCID)...
January 10, 2019: Thrombosis and Haemostasis
Herbert Kaltner, Hans-Joachim Gabius
Although a plethora of players has already been revealed to be engaged in the haemostatic system, a fundamental consideration of the molecular nature of information coding can give further explorations of the mechanisms of blood clotting, platelet functionality and vascular trafficking direction. By any measures, looking at ranges of occurrence and of potential for structural versatility, at strategic positioning to influence protein and cell sociology as well as at dynamics of processing and restructuring for phenotypic variability, using sugars as an alphabet of life for generating the glycan part of glycoconjugates is a success story...
January 8, 2019: Thrombosis and Haemostasis
Christian Schulte, Manuel Mayr
No abstract text is available yet for this article.
January 8, 2019: Thrombosis and Haemostasis
Md Sanaullah Sajib, Constantinos M Mikelis
No abstract text is available yet for this article.
January 8, 2019: Thrombosis and Haemostasis
Constantin von Zur Mühlen, Wolfgang Bothe, Christoph Bode
No abstract text is available yet for this article.
January 8, 2019: Thrombosis and Haemostasis
Maria Troullinaki, Ruben Garcia-Martin, David Sprott, Anne Klotzsche-von Ameln, Sylvia Grossklaus, Ioannis Mitroulis, Triantafyllos Chavakis, Matina Economopoulou
The replication stress inflicted on retinal endothelial cells (ECs) in the context of hypoxia-induced pathological neovascularization during proliferative retinopathy is linked with activation of the deoxyribonucleic acid (DNA) repair response. Here, we studied the effect of deficiency of the DNA damage response adaptor 53BP1, which is an antagonist of homologous recombination (HR), in the context of proliferative retinopathy. In the model of retinopathy of prematurity (ROP), 53BP1-deficient mice displayed increased hypoxia-driven pathological neovascularization and tuft formation, accompanied by increased EC proliferation and reduced EC apoptosis, as compared with 53BP1-sufficient mice...
January 8, 2019: Thrombosis and Haemostasis
Kevin R An, Emilie P Belley-Cote, Kevin J Um, Saurabh Gupta, Graham R McClure, Iqbal H Jaffer, Arjun Pandey, Jessica Spence, Sake J Van der Wall, John W Eikelboom, Richard P Whitlock
BACKGROUND:  The optimal antithrombotic therapy after surgical bioprosthetic aortic valve replacement (BAVR) is uncertain. We conducted a systematic review and meta-analysis of observational studies and randomized controlled trials (RCTs) comparing antiplatelet therapy and anticoagulation in patients with surgical BAVR. METHODS:  We searched Cochrane CENTRAL, MEDLINE and EMBASE from inception to 3 November 2017 for studies evaluating antiplatelet therapy versus anticoagulation early after surgical BAVR...
January 7, 2019: Thrombosis and Haemostasis
Francesco Violi, Gino Roberto Corazza, Stephen H Caldwell, Giovanni Talerico, Giulio Francesco Romiti, Laura Napoleone, Francesco Perticone, Luigi Bolondi, Antonello Pietrangelo, Anna Rita Vestri, Valeria Raparelli, Stefania Basili
No abstract text is available yet for this article.
January 7, 2019: Thrombosis and Haemostasis
Xiaolan Yao, Wenpei Chen, Jin Liu, Han Liu, Janis Y Zhan, Shixia Guan, Ziqi Lu, Ping Tang, Peng Li, Baoqin Lin
BACKGROUND:  Inflammation plays an important role in thrombus formation, and Sirtuin 1 (SIRT1) negatively regulates inflammation via deacetylating nuclear factor-kappa B. However, the relationship between SIRT1-regulated inflammation and deep vein thrombosis (DVT) is still unknown. OBJECTIVE:  The aim of this study was to investigate whether SIRT1 plays a critical role in inferior vena cava (IVC) stenosis-induced DVT. MATERIALS AND METHODS:  Thrombus weight and histopathologic analysis of IVC were evaluated at different time points after IVC stenosis in rats...
January 7, 2019: Thrombosis and Haemostasis
Raquel Guillamat Prats, Martina Rami, Larisa Ring, Petteri Rinne, Estelle Lauer, Sebastien Lenglet, Aurelien Thomas, Sabrina Pagano, Nicolas Vuilleumier, Benjamin F Cravatt, Christian Weber, Alexander Faussner, Sabine Steffens
No abstract text is available yet for this article.
January 4, 2019: Thrombosis and Haemostasis
Rita Campanelli, Alessia Claudia Codazzi, Valentina Poletto, Carlotta Abbà, Paolo Catarsi, Gabriela Fois, Maria Antonietta Avanzini, Valeria Brazzelli, Chryssoula Tzialla, Annalisa De Silvestri, Carmine Tinelli, Amelia Licari, Roberto Berra-Romani, Estella Zuccolo, Francesco Moccia, Savina Mannarino, Vittorio Rosti, Margherita Massa
Endothelial progenitor cells (EPCs) have been suggested to contribute to the neovascularization of infantile haemangioma (IH). There is strong evidence of the efficacy of propranolol in the treatment of IH, possibly by inhibiting both vasculogenesis and angiogenesis in the tumour. We evaluate the frequency of circulating endothelial colony forming cells (ECFCs), as the best EPC surrogate, in patients with IH at diagnosis and while receiving propranolol by an ex vivo 12-month longitudinal study. Biological aspects of the ECFCs, such as their in vitro angiogenic potential, membrane CXCR4 expression and Ca2+ signalling, were investigated...
January 4, 2019: Thrombosis and Haemostasis
Sarah Bos, Bente van den Boom, Pieter W Kamphuisen, Jelle Adelmeijer, Hans Blokzijl, Tim Schreuder, Ton Lisman
BACKGROUND AND AIM:  Patients with cirrhosis may acquire profound changes in haemostasis. Although haemostatic changes in cirrhosis have been extensively studied, most studies were performed in groups of patients with mixed aetiology. As thrombotic events appear more common in some aetiologies of disease, notably non-alcoholic steatohepatitis (NASH) and cholestatic disease, we hypothesized that haemostatic changes might be different across aetiologies. PATIENTS AND METHODS:  We studied 109 patients with cirrhosis (31 cholestatic liver disease, 23 NASH, 37 alcoholic liver disease [ALD], 18 viral hepatitis) and 44 healthy controls...
January 4, 2019: Thrombosis and Haemostasis
Jin-Sin Koh, Yongwhi Park, Jong-Hwa Ahn, Min Gyu Kang, Kye-Hwan Kim, Jae Seok Bae, Hyun Woong Park, Jeong Yoon Jang, Jeong Rang Park, Seok-Jae Hwang, Choong Hwan Kwak, Jin-Yong Hwang, Udaya S Tantry, Paul A Gurbel, Young-Hoon Jeong
Amlodipine has a potential to reduce clopidogrel bioactivation through the cytochrome P450 3A4 enzyme in vivo, but the clinical impact of this interaction remains controversial. This randomized, open-label, two-period, crossover study was performed to evaluate the influence of amlodipine on the haemostatic profiles of high-risk patients during clopidogrel treatment. We recruited 40 Asian patients (Male/Female: n  = 36/4) receiving clopidogrel (75 mg/day), aspirin (100 mg/day) and rosuvastatin for at least 6 months following percutaneous coronary intervention...
January 4, 2019: Thrombosis and Haemostasis
Da Zhou, Jiayue Ding, Karam Asmaro, Liqun Pan, Jingyuan Ya, Qi Yang, Chunqiu Fan, Yuchuan Ding, Xunming Ji, Ran Meng
Recently, internal jugular vein stenosis (IJVS) is gaining increasing attention from clinical researchers due to a series of confounding symptoms that impair the quality of life in affected individuals but cannot be explained by other well-established causes. In this study, we aimed to elucidate the clinical features, neuroimaging characteristics and pathogenesis of IJVS, and explore their possible correlations, in attempt to provide useful clues for clinical diagnosis and treatment. Forty-three eligible patients with unilateral or bilateral IJVS confirmed by contrast-enhanced magnetic resonance venography of the brain and neck were enrolled in this study...
January 3, 2019: Thrombosis and Haemostasis
Francesco Paciullo, Stefania Momi, Paolo Gresele
Since increased cholesterol levels are crucial in determining the development of atheroma, their reduction represents a mainstay in primary and secondary cardiovascular prevention. The most recent spectacular advancement in cholesterol-lowering therapy is represented by proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors. Although their benefit over currently available treatments has been ascribed primarily to their strong low-density lipoprotein (LDL)-cholesterol reducing action, several clues suggest that PCSK9 inhibitors may also influence platelet function and blood coagulation...
January 3, 2019: Thrombosis and Haemostasis
Agata H Bryk, Malgorzata Konieczynska, Pawel Rostoff, Elzbieta Broniatowska, Jerzy Hohendorff, Maciej T Malecki, Anetta Undas
OBJECTIVE:  We investigated clinical and laboratory determinants of plasma protein oxidation and its associations with clot fibrinolysis in type 2 diabetes patients. MATERIALS AND METHODS:  Our cross-sectional study consisted of 246 type 2 diabetic patients, 143 (58%) with concomitant cardiovascular disease (CVD), including 41 (17%) with previous myocardial infarction (MI). We measured total protein carbonylation (PC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) along with clot lysis time (CLT) and clot permeation ( Ks ), fibrinogen, plasminogen, α-2-antiplasmin, plasminogen activator inhibitor-1 (PAI-1), thrombin activatable fibrinolysis inhibitor (TAFI) and thrombomodulin...
January 3, 2019: Thrombosis and Haemostasis
Hyunjean Jung, Pil-Sung Yang, Jung-Hoon Sung, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung
BACKGROUND:  There have been no prior nationwide reports on the prevalence of hypertrophic cardiomyopathy (HCM) among patients suffering from atrial fibrillation (AF). It is also unclear how much stroke risk is attributable to HCM compared with other stroke risks in patients with AF. This study assessed the prevalence of HCM among non-valvular AF (NVAF) patients and to assess the magnitude of increase in stroke risk in NVAF patients with HCM, compared with those without HCM. PATIENTS AND METHODS:  From the Korean National Health Insurance Service database from January 1, 2005 to December 31, 2016, we analysed 979,784 patients with prevalent NVAF aged 18 years or older...
January 2, 2019: Thrombosis and Haemostasis
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