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Thrombosis and Haemostasis

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https://www.readbyqxmd.com/read/29310141/mutation-of-the-rpvr-propeptide-motif-at-c-terminal-of-the-a%C3%AE-chain-is-associated-with-decreased-fibrinogen-expression
#1
Stephen O Brennan, Andrew D Laurie
No abstract text is available yet for this article.
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304542/editors-choice-in-the-60th-anniversary-year-of-thrombosis-and-haemostasis-past-present-and-future
#2
Christian Weber, Gregory Y H Lip
No abstract text is available yet for this article.
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304541/rationale-design-and-methodology-of-the-computerized-registry-of-patients-with-venous-thromboembolism-riete
#3
Behnood Bikdeli, David Jimenez, Mayra Hawkins, Salvador Ortíz, Paolo Prandoni, Benjamin Brenner, Hervé Decousus, Frederick A Masoudi, Javier Trujillo-Santos, Harlan M Krumholz, Manuel Monreal
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a preventable cause of in-hospital death, and one of the most prevalent vascular diseases. There is a lack of knowledge with regards to contemporary presentation, management and outcomes of patients with VTE. Many clinically important subgroups (including the elderly, those with recent bleeding and pregnant patients) have been under-represented in clinical trials. Furthermore, design of clinical trials is challenging in some scenarios, such as in those with hemodynamically unstable PE...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304540/the-adam17-metalloproteinase-maintains-arterial-elasticity
#4
Alexandros Nicolaou, Bernd H Northoff, Zhen Zhao, Alexander Kohlmaier, Kristina Sass, Stefan Rose-John, Sabine Steffens, Christian Weber, Daniel Teupser, Lesca M Holdt
No abstract text is available yet for this article.
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304539/expression-and-cellular-localization-of-cxcr4-and-cxcl12-in-human-carotid-atherosclerotic-plaques
#5
Sophie Merckelbach, Emiel P C van der Vorst, Michael Kallmayer, Christoph Rischpler, Rainer Burgkart, Yvonne Döring, Gert-Jan de Borst, Markus Schwaiger, Hans-Henning Eckstein, Christian Weber, Jaroslav Pelisek
BACKGROUND AND AIMS:  The CXCR4/CXCL12 complex has already been associated with progression of atherosclerosis; however, its exact role is yet unknown. The aim of this study was to analyse the expression and cellular localization of CXCL12 and its receptor CXCR4 in human carotid atherosclerotic plaques. METHODS:  Carotid plaques (n = 58; 31 stable, 27 unstable, based on histological characterization of plaque morphology) were obtained during carotid endarterectomy, and 10 healthy vessels were used as a control...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#6
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/-) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304537/clinical-impact-and-course-of-anticoagulant-related-major-bleeding-in-cancer-patients
#7
Noémie Kraaijpoel, Nick van Es, Suzanne M Bleker, Marjolein P A Brekelmans, Elise S Eerenberg, Saskia Middeldorp, Alexander T Cohen, Gary E Raskob, Harry R Büller
Cancer patients with venous thromboembolism (VTE) have a two- to six-fold increased risk of anticoagulant-related major bleeding events compared with VTE patients without cancer. It is unknown whether major bleeding events are more severe in cancer patients than in those without cancer. Individual patient data from four randomized phase III trials that compared factor Xa inhibitors and vitamin K antagonists for the treatment of VTE were used to compare the severity of major bleeding events in patients with and without cancer...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304536/defibrotide-stimulates-angiogenesis-and-protects-endothelial-cells-from-calcineurin-inhibitor-induced-apoptosis-via-upregulation-of-akt-bcl-xl
#8
Xiangmin Wang, Bin Pan, Yuko Hashimoto, Hiroshi Ohkawara, Kailin Xu, Lingyu Zeng, Takayuki Ikezoe
Sinusoidal obstruction syndrome is a life-threatening complication that can occur after haematopoietic stem cell transplantation. Defibrotide (DF) has been approved for the treatment of individuals with severe sinusoidal obstruction syndrome following haematopoietic stem cell transplantation in the European Union and the United States. However, the precise mechanisms by which DF protects endothelial cells remain to be elucidated. In this study, we found that DF stimulated angiogenesis in vitro and in vivo as assessed by vascular tube formation, scratch-wound repair and Matrigel plug assays...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304535/circulating-angiogenic-mediators-in-patients-with-moderate-and-severe-von-willebrand-disease-a-multicentre-cross-sectional-study
#9
Dafna J Groeneveld, Yvonne V Sanders, Jelle Adelmeijer, Evelien P Mauser-Bunschoten, Johanna G van der Bom, Marjon H Cnossen, Karin Fijnvandraat, Britta A P Laros-van Gorkom, Karina Meijer, Ton Lisman, Jeroen Eikenboom, Frank W G Leebeek
Inhibition of von Willebrand factor (VWF) expression in endothelial cells results in enhanced, possible dysfunctional angiogenesis, consistent with observations of severe gastrointestinal bleedings caused by vascular malformations in patients with von Willebrand disease (VWD). VWF is stored in endothelial Weibel-Palade bodies (WPB) with several other mediators of angiogenesis, like angiopoietin-2, osteoprotegerin and galectin-3. Increased release of angiopoietin-2 has been observed in medium of endothelial cells lacking VWF, but data on circulating levels of angiogenic factors in patients with VWD are lacking...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304534/platelet-function-in-itp-independent-of-platelet-count-is-consistent-over-time-and-is-associated-with-both-current-and-subsequent-bleeding-severity
#10
A L Frelinger, R F Grace, A J Gerrits, S L Carmichael, E E Forde, A D Michelson
BACKGROUND:  Treatment decisions for patients with immune thrombocytopenia (ITP) are difficult because patients with similarly low platelet counts differ in their bleeding tendency. We recently reported that platelet function tests, independent of platelet count, are associated with concurrent bleeding severity, suggesting that these tests may be useful indicators of future bleeding in ITP. OBJECTIVES:  To test this hypothesis, we evaluated the consistency of these platelet function tests over time and their association with subsequent bleeding severity...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304533/release-of-platelet-derived-sphingosine-1-phosphate-involves-multidrug-resistance-protein-4-mrp4-abcc4-and-is-inhibited-by-statins
#11
Katja Vogt, Shailaja Mahajan-Thakur, Robert Wolf, Susanne Bröderdorf, Conny Vogel, Andreas Böhm, Christoph A Ritter, Markus Gräler, Stefan Oswald, Andreas Greinacher, Heyo K Kroemer, Gabriele Jedlitschky, Bernhard H Rauch
Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. A candidate transport protein is the multidrug resistance protein 4 (MRP4/ABCC4), an ATP-dependent transporter highly expressed in platelets. Furthermore, several statins are known to affect platelet functions and exhibit antithrombotic properties. This study determines the involvement of MRP4 in the transport of S1P and a possible interference by statins...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304532/platelet-count-adamts13-activity-von-willebrand-factor-level-and-survival-in-patients-with-colorectal-cancer-5-year-follow-up-study
#12
Nóra Garam, Éva Maláti, György Sinkovits, Tímea Gombos, Attila Szederjesi, Loránd Barabás, László Gráf, Judit Kocsis, Zoltán Prohászka
Distant metastasis is a major cause of colorectal cancer-related death, but the mechanism of tumour progression is not fully understood. There is growing evidence of an interaction between tumour cells and platelets which may influence tumour progression and metastasis formation. Quality and quantity of von Willebrand factor may regulate the interaction between tumour cells and platelets. Our aim was to measure the platelet count, von Willebrand factor antigen (VWF:Ag) levels and ADAMTS13 activity in a large (n = 232) cohort of colorectal cancer patients and to examine their relationships with the stage of the disease and 5-year survival without thrombotic complications using multivariable models...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304531/dietary-nitrate-supplementation-reduces-circulating-platelet-derived-extracellular-vesicles-in-coronary-artery-disease-patients-on-clopidogrel-therapy-a-randomised-double-blind-placebo-controlled-study
#13
Nicholas Burnley-Hall, Fairoz Abdul, Vitaliy Androshchuk, Keith Morris, Nick Ossei-Gerning, Richard Anderson, D Aled Rees, Philip E James
Extracellular vesicles (EVs) are implicated in the pathogenesis of cardiovascular disease (CVD). Specifically, platelet-derived EVs are highly pro-coagulant, promoting thrombin generation and fibrin clot formation. Nitrate supplementation exerts beneficial effects in CVD, via an increase in nitric oxide (NO) bioavailability. Clopidogrel is capable of producing NO-donating compounds, such as S-nitrosothiols (RSNO) in the presence of nitrite and low pH. The aim of this study was to assess the effect of nitrate supplementation with versus without clopidogrel therapy on circulating EVs in coronary artery disease (CAD) patients...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304530/alteration-of-von-willebrand-factor-after-transcatheter-aortic-valve-replacement-in-the-absence-of-paravalvular-regurgitation
#14
Felix Pawlitschek, Cornelius Keyl, Barbara Zieger, Ulrich Budde, Friedhelm Beyersdorf, Franz-Josef Neumann, Christian Stratz, Thomas G Nührenberg, Dietmar Trenk
Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients with mild paravalvular regurgitation, and whether there are differences between patients undergoing conventional aortic valve replacement (AVR) or TAVI. We analysed the multimeric structure of VWF and the ratio of VWF collagen-binding capacity to VWF antigen pre- and postoperatively in 12 patients scheduled for AVR and in 31 patients scheduled for TAVI...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304529/passivating-injured-endothelium-with-kinexins-in-thrombolytic-therapy
#15
Yunn-Hwa Ma, Chao-Wei Huang, Chih-Jen Wen, Yi-Ching Lu, Shiaw-Pyng Wey, Tze-Chein Wun
Without conjunctive administration of an anticoagulant, endothelial injury-induced thrombosis is resistant to thrombolysis and prone to re-thrombosis. We hypothesized that co-delivery of recombinant tissue plasminogen activator (rtPA) with annexin V-containing anticoagulants that specifically target the injured endothelium may passivate the thrombogenic elements of the vascular injury site and enhance rtPA-induced thrombolysis. In this study, the effects of conjunctive administration of Kinexins (Kunitz inhibitor-annexin V fusion proteins) with rtPA on thrombolysis were determined in vitro and in vivo...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304528/comparative-performance-of-clinical-risk-assessment-models-for-hospital-acquired-venous-thromboembolism-in-medical-patients
#16
Marc Blondon, David Spirk, Nils Kucher, Drahomir Aujesky, Daniel Hayoz, Jürg H Beer, Marc Husmann, Beat Frauchiger, Wolfgang Korte, Walter A Wuillemin, Henri Bounameaux, Marc Righini, Mathieu Nendaz
BACKGROUND:  Improved thromboprophylaxis for acutely ill medical patients relies on valid predictions of thrombotic risks. Our aim was to compare the performance of the Improve and Geneva clinical risk assessment models (RAMs), and to simplify the current Geneva RAM. METHODS:  Medical inpatients from eight Swiss hospitals were prospectively followed during 90 days, for symptomatic venous thromboembolism (VTE) or VTE-related death. We compared discriminative performance and calibration of the RAMs, using time-to-event methods with competing risk modelling of non-VTE death...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304527/is-there-a-preferred-stroke-prevention-strategy-for-diabetic-patients-with-non-valvular-atrial-fibrillation-comparing-warfarin-dabigatran-and-rivaroxaban
#17
Chih-Cheng Hsu, Pai-Feng Hsu, Shih-Hsien Sung, Shih-Te Tu, Ben-Hui Yu, Chi-Jung Huang, Hao-Min Cheng
BACKGROUND:  The prevalence of diabetes is growing, and diabetes is an independent risk factor for both atrial fibrillation (AF) and stroke. However, the relative effectiveness and safety of different oral anticoagulants for diabetic patients with non-valvular AF remain unclear. We aimed to compare thromboembolic events, bleeding and mortality in diabetic AF patients treated with rivaroxaban, dabigatran and warfarin. METHODS AND RESULTS:  Diabetic AF patients taking dabigatran (n = 322), rivaroxaban (n = 320) or warfarin (n = 1,899) were identified from the nationwide diabetes pay-for-performance program (n = 814,465) in Taiwan...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304526/thromboelastometry-and-platelet-function-during-acclimatization-to-high-altitude
#18
Alistair S Rocke, Gordon G Paterson, Matthew T Barber, Alexander I R Jackson, Shona Main, Calum Stannett, Martin F Schnopp, J Kenneth Baillie, Elizabeth H Horne, Carl Moores, Paul Harrison, Alastair F Nimmo, A A Roger Thompson
Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304525/low-self-rated-health-is-related-to-blood-hypercoagulability-in-patients-admitted-with-acute-myocardial-infarction
#19
Roland von Känel, Rebecca E Meister-Langraf, Jean-Paul Schmid, Jürgen Barth, Hansjörg Znoj, Ulrich Schnyder, Mary Princip
Self-rated health (SRH) is independently associated with all-cause mortality and adverse cardiovascular outcomes in individuals with and without cardiovascular disease. We examined whether SRH relates to haemostatic factors of a hypercoagulable state with prognostic impact in patients admitted with acute myocardial infarction (MI). We assessed 190 patients (median age: 59 years; all Caucasian; 83% men) within 48 hours of an acute coronary intervention in terms of demographic factors, medical and psychiatric comorbidity, health behaviours, cardiac-related variables and psychosocial characteristics...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304524/amino-fucoidan-as-a-vector-for-rtpa-induced-fibrinolysis-in-experimental-thrombotic-events
#20
Radouane Ghebouli, Stephane Loyau, Murielle Maire, Pierre Saboural, Jean-Philippe Collet, Martine Jandrot-Perrus, Didier Letourneur, Frédéric Chaubet, Jean-Baptiste Michel
Acute ischaemic stroke, myocardial infarction and pulmonary embolism are the main causes of mortality and morbidity worldwide. Thrombolysis by intravenous injection of recombinant tissue plasminogen activator (rtPA) remains the most common non-interventional treatment to recanalize occluded vessels. However, this procedure is limited by significant drawbacks, including high doses and bleeding complications. Recent studies showed that fucoidan targets the intraluminal thrombus in vivo. We have developed a chimaera covalently linking fucoidan, able to target platelets within the thrombus, to dilysine, able to non-covalently bind rtPA...
January 2018: Thrombosis and Haemostasis
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