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Thrombosis and Haemostasis

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https://www.readbyqxmd.com/read/28816342/hypofibrinogenaemia-associated-with-novel-a%C3%AE-126val%C3%A2-asp-mutation-in-the-fibrinogen-coiled-coil
#1
Stephen O Brennan, Stephen Brennan, Andrew D Laurie
No abstract text is available yet for this article.
August 17, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28816341/clinical-impact-of-major-bleeding-in-patients-with-venous-thromboembolism-treated-with-factor-xa-inhibitors-or-vitamin-k-antagonists-an-individual-patient-data-meta-analysis
#2
Suzanne M Bleker, Marjolein P A Brekelmans, Elise S Eerenberg, Alexander T Cohen, Saskia Middeldorp, Gary Raskob, Harry R Büller
Factor Xa (fXa)-inhibitors are as effective and safer than vitamin-K-antagonists (VKA) in the treatment of venous thromboembolism (VTE). We previously classified the severity of clinical presentation and course of all major bleeding events from the EINSTEIN, AMPLIFY and HOKUSAI-VTE trials separately. The current aim was to combine these findings in order to increase precision, assess a class effect and analyse presentation and course for different types of bleeding, i. e. intracranial, gastro-intestinal, and other...
August 17, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28816340/coagulation-factor-xii-regulates-inflammatory-responses-in-human-lungs
#3
Rosanna Hess, Lukasz Wujak, Christina Hesse, Katherina Sewald, Danny Jonigk, Gregor Warnecke, Hans-Gerd Fieguth, Steven de Maat, Coen Maas, Francesco Bonella, Klaus T Preissner, Benjamin Weiss, Liliana Schaefer, Wolfgang M Kuebler, Philipp Markart, Malgorzata Wygrecka
Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact phase system were characterized in bronchoalveolar lavage fluids (BALF) from 54 ARDS patients and 43 controls, and their impact on cytokine/chemokine expression in human precision cut lung slices (PCLS) was assessed by a PCR array...
August 17, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28799620/long-term-bleeding-risk-prediction-in-real-world-patients-with-atrial-fibrillation-comparison-of-the-has-bled-and-abc-bleeding-risk-scores-the-murcia-atrial-fibrillation-project
#4
María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan, Vicente Vicente, Mariano Valdés, Francisco Marín, Gregory Y H Lip
Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better than HAS-BLED score in a clinical trial cohort but has not been externally validated. It was the aim of this study to compare the predictive performance of the ABC-Bleeding score compared to HAS-BLED score in an independent "real-world" anticoagulated AF patients with long-term follow-up...
August 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28799619/paracelsus-poison-and-colistin
#5
Heiko Herwald
No abstract text is available yet for this article.
August 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28796276/colistin-dampens-fibrinolysis-and-endothelial-activation-during-endotoxaemia-a-randomised-double-blind-trial
#6
Christian Schoergenhofer, Peter Matzneller, Marion Mußbacher, Johannes A Schmid, Petra Jilma-Stohlawetz, Markus Zeitlinger, Bernd Jilma
Colistin electrostatically interacts with lipopolysaccharides (LPS). Pre-clinical studies demonstrated beneficial effects of colistin on LPS-induced coagulation and fibrinolysis. The objective of this trial was to investigate the effects of colistin during experimental endotoxaemia. In this randomised, double-blind, placebo-controlled, crossover trial 16 healthy volunteers received a 2 ng/kg LPS bolus after infusion of 2.5 million IU colistin or placebo. Plasma levels of F1+2 prothrombin fragments, thrombin-antithrombin complexes (TAT), von Willebrand factor antigen levels (vWF), E-selectin, plasmin-antiplasmin complexes (PAP), tissue-type plasminogen activator (t-PA) antigen and activity, plasminogen activator inhibitor-1 (PAI-1) were measured...
August 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28796275/immature-platelets-as-a-novel-biomarker-for-adverse-cardiovascular-events-in-patients-after-non-cardiac-surgery
#7
Aida Anetsberger, Manfred Blobner, Bernhard Haller, Sebastian Schmid, Katrin Umgelter, Theresa Hager, Clemens Langgartner, Eberhard F Kochs, Karl-Ludwig Laugwitz, Bettina Jungwirth, Isabell Bernlochner
This study evaluates whether immature platelets (IPF) determined in the post anesthesia care unit (PACU) can predict major adverse cardiovascular events (MACE) or other thromboembolic events after intermediate and high-risk surgery. IPF are increased in patients with acute coronary syndrome and recently gained interest as novel biomarker for risk stratification. In this prospective observational trial 732 patients undergoing intermediate or high-risk non-cardiac surgery were enrolled (NCT02097602). IPF was measured preoperatively and postoperatively in the PACU...
August 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28796274/endothelial-cell-specific-overexpression-of-developmental-endothelial-locus-1-does-not-influence-atherosclerosis-development-in-apoe-mice
#8
Pallavi Subramanian, Marta Prucnal, Bettina Gercken, Matina Economopoulou, George Hajishengallis, Triantafyllos Chavakis
No abstract text is available yet for this article.
August 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28796273/role-of-replacement-therapy-in-the-evaluation-of-thrombosis-occurring-in-congenital-bleeding-conditions
#9
Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, Bruno Girolami
No abstract text is available yet for this article.
August 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771280/comparison-of-clinical-probability-adjusted-d-dimer-and-age-adjusted-d-dimer-interpretation-to-exclude-venous-thromboembolism
#10
Sarah Takach Lapner, Jim A Julian, Lori-Ann Linkins, Shannon Bates, Clive Kearon
Two new strategies for interpreting D-dimer results have been proposed: i) using a progressively higher D-dimer threshold with increasing age (age-adjusted strategy) and ii) using a D-dimer threshold in patients with low clinical probability that is twice the threshold used in patients with moderate clinical probability (clinical probability-adjusted strategy). Our objective was to compare the diagnostic accuracy of age-adjusted and clinical probability-adjusted D-dimer interpretation in patients with a low or moderate clinical probability of venous thromboembolism (VTE)...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771279/superoxide-dismutase-2-is-dispensable-for-platelet-function
#11
Trevor P Fidler, Jesse W Rowley, Claudia Araujo, Luc H Boudreau, Alex Marti, Rhonda Souvenir, Kali Dale, Eric Boilard, Andrew S Weyrich, E Dale Abel
Increased intracellular reactive oxygen species (ROS) promote platelet activation. The sources of platelet-derived ROS are diverse and whether or not mitochondrial derived ROS, modulates platelet function is incompletely understood. Studies of platelets from patients with sickle cell disease, and diabetes suggest a correlation between mitochondrial ROS and platelet dysfunction. Therefore, we generated mice with a platelet specific knockout of superoxide dismutase 2 (SOD2-KO) to determine if increased mitochondrial ROS increases platelet activation...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771278/co-injection-of-mesenchymal-stem-cells-with-endothelial-progenitor-cells-accelerates-muscle-recovery-in-hind-limb-ischemia-through-an-endoglin-dependent-mechanism
#12
Elisa Rossi, David Smadja, Celine Goyard, Audrey Cras, Blandine Dizier, Nour Bacha, Anna Lokajczyk, Coralie L Guerin, Nicolas Gendron, Benjamin Planquette, Virginie Mignon, Carmelo Bernabéu, Olivier Sanchez, David M Smadja
Endothelial colony-forming cells (ECFCs) are progenitor cells committed to endothelial lineages and have robust vasculogenic properties. Mesenchymal stem cells (MSCs) have been described to support ECFC-mediated angiogenic processes in various matrices. However, MSC-ECFC interactions in hind limb ischemia (HLI) are largely unknown. Here we examined whether co-administration of ECFCs and MSCs bolsters vasculogenic activity in nude mice with HLI. In addition, as we have previously shown that endoglin is a key adhesion molecule, we evaluated its involvement in ECFC/MSC interaction...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771277/plasma-fibrin-clot-properties-in-the-g20210a-prothrombin-mutation-carriers-following-venous-thromboembolism-the-effect-of-rivaroxaban
#13
Agnieszka Janion-Sadowska, Joanna Natorska, Jakub Siudut, Michal Ząbczyk, Andrzej Stanisz, Anetta Undas
We sought to investigate whether the G20210A prothrombin mutation modifies plasma fibrin clot properties in patients after venous thromboembolism (VTE) and how rivaroxaban treatment affects these alterations. We studied 34 prothrombin mutation heterozygous carriers and sex- and age-matched 34 non-carriers, all at least three months since the first VTE episode, before and during treatment with rivaroxaban. Clot permeability (Ks) and clot lysis time (CLT) with or without elimination of thrombin activatable fibrinolysis inhibitor (TAFI) were assessed at baseline, 2-6 hours (h) after and 20-25 h after intake of rivaroxaban (20 mg/day)...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771276/downregulation-of-hypoxia-inducible-factor-1%C3%AE-contributes-to-impaired-megakaryopoiesis-in-immune-thrombocytopenia
#14
Jiaqian Qi, Tao You, Tingting Pan, Qi Wang, Li Zhu, Yue Han
Impaired megakaryocyte maturation and exaggerated platelet destruction play a pivotal role in the pathogenesis of immune thrombocytopenia (ITP). Previous studies have shown that HIF-1α promotes the homing and engraftment of haematopoietic stem cells (HSCs), thereby stimulating HSC differentiation. However, whether HIF-1α plays a role in megakaryocytic maturation and platelet destruction in ITP remains elusive. Using enzyme-linked immunosorbent assays (ELISAs), we demonstrated that there were lower HIF-1α levels in the bone marrow (BM) of ITP patients than in that of healthy donors and patients with chemotherapy-related thrombocytopenia...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28771275/latency-transition-of-plasminogen-activator-inhibitor-type-1-is-evolutionarily-conserved
#15
Agnieszka Jendroszek, Malene S Sønnichsen, Andrés C Muñoz, Kato Leyman, Anni Christensen, Steen Vang Petersen, Tobias Wang, Christian Bendixen, Frank Panitz, Peter A Andreasen, Jan K Jensen
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodelling. PAI-1 belongs to the serpin superfamily and unlike other inhibitory serpins undergoes a spontaneous inactivation process under physiological conditions, termed latency transition. During latency transition the solvent exposed reactive centre loop is inserted into the central β-sheet A of the molecule, and is no longer accessible to reaction with the protease. More than three decades of research on mammalian PAI-1 has not been able to clarify the evolutionary advantage and physiological relevance of latency transition...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28783201/validation-of-the-dapt-score-in-patients-randomized-to-6-or-12-months-clopidogrel-after-predominantly-second-generation-drug-eluting-stents
#16
Yukinori Harada, Jonathan Michel, Raphaela Lohaus, Katharina Mayer, Roberto Emmer, Anna Lena Lahmann, Roisin Colleran, Daniele Giacoppo, Annabelle Wolk, Jurrien M Ten Berg, Franz-Josef Neumann, Yaling Han, Tom Adriaenssens, Ralph Tölg, Melchior Seyfarth, Michael Maeng, Bernhard Zrenner, Claudius Jacobshagen, Jochen Wöhrle, Sebastian Kufner, Tanja Morath, Tareq Ibrahim, Isabell Bernlochner, Marcus Fischer, Heribert Schunkert, Karl-Ludwig Laugwitz, Julinda Mehilli, Robert A Byrne, Adnan Kastrati, Stefanie Schulz-Schüpke
The DAPT score is a recently-proposed decision tool for guiding optimal duration of dual antiplatelet therapy (DAPT). It showed modest accuracy in prior derivation and validation cohorts of patients with ≥12 months DAPT. This study was aimed to evaluate the validity of the DAPT score in a cohort of patients with 6 or 12 months DAPT after implantation of predominantly second-generation drug-eluting stents. We analyzed data of patients enrolled in the ISAR-SAFE trial. Patients were classified into low (<2) or high (≥2) DAPT score groups...
July 27, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28726980/interdependence-between-osteoprotegerin-and-active-von-willebrand-factor-in-long-term-cardiovascular-mortality-prediction-in-patients-undergoing-percutaneous-coronary-intervention
#17
Jolanta Siller-Matula, Irene M Lang, Christian Schoergenhofer, Mark Roest, Bernd Jilma
The interdependence of the predictive accuracy of serum osteoprotegerin (OPG) and von Willebrand factor (vWF) levels for long-term cardiovascular outcomes has not been investigated so far. This was a prospective observational cohort study in 361 patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Baseline levels of OPG, vWF, active vWF (act vWF) and ristocetin cofactor activity (vWF:RICO) were measured. Cardiovascular mortality was recorded over a median of five years...
July 20, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28726978/analysis-of-the-substrate-specificity-of-factor-vii-activating-protease-fsap-and-design-of-specific-and-sensitive-peptide-substrates
#18
Emrah Kara, Dipankar Manna, Geir Åge Løset, Eric L Schneider, Charles S Craik, Sandip Kanse
Factor VII (FVII) activating protease (FSAP) is a circulating serine protease that is likely to be involved in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To date, no systematic information is available about the substrate specificity of FSAP. Applying phage display and positional scanning substrate combinatorial library (PS-SCL) approaches we have characterised the specificity of FSAP towards small peptides. Results were evaluated in the context of known protein substrates as well as molecular modelling of the peptides in the active site of FSAP...
July 20, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28726976/absence-of-transforming-growth-factor-beta-1-in-murine-platelets-reduces-neointima-formation-without-affecting-arterial-thrombosis
#19
Katrin Schaefer, Eva Schütz, Magdalena L Bochenek, Dennis R Riehl, Markus Bosmann, Thomas Münzel, Stavros Konstantinides
Platelet degranulation at the site of vascular injury prevents bleeding and may affect the chronic vascular wound healing response. Transforming Growth Factor (TGF)-β1 is a major component of platelet α-granules known to accumulating in thrombi. It was our aim to determine the role of TGFβ1 released from activated platelets for neointima formation following arterial injury and thrombosis. Mice with platelet-specific deletion of TGFβ1 (Plt.TGFβ-KO) underwent carotid artery injury. Immunoassays confirmed the absence of active TGFβ1 in platelet releasates and plasma of Plt...
July 20, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28726972/consequences-of-warfarin-suspension-after-major-bleeding-in-very-elderly-patients-with-non-valvular-atrial-fibrillation
#20
Giacomo Zoppellaro, Serena Granziera, Giulia Bertozzo, Gentian Denas, Lucia Marigo, Florinda Petruzzellis, Seena Padayattil Jose, Katia Rossi, Giovanni Nante, Vittorio Pengo
No abstract text is available yet for this article.
July 20, 2017: Thrombosis and Haemostasis
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