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Thrombosis and Haemostasis

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https://www.readbyqxmd.com/read/29044298/the-performance-of-crusade-and-acuity-bleeding-risk-scores-in-ticagrelor-treated-acs-patients-who-underwent-pci
#1
Shaozhi Xi, Shanshan Zhou, Xuyun Wang, Jia Liu, Liuan Qin, Jun Liu, Tong Yin, Yundai Chen
The performance of the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) and ACUITY (Acute Catheterization and Urgent Intervention Triage strategy) risk scores for the prediction of major bleeding in ticagrelor-treated acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI) is unknown. The aim of the present study is to validate the performance of both scores in a contemporary Chinese cohort of ACS patients hospitalized for PCI and administrated with ticagrelor...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044295/clinical-decision-rules-for-pulmonary-embolism-in-hospitalized-patients-a-systematic-literature-review-and-meta-analysis
#2
Anne R Bass, Kara G Fields, Rie Goto, Gregory Turissini, Shirin Dey, Linda A Russell
Background Clinical decision rules (CDRs) for pulmonary embolism (PE) have been validated in outpatients, but their performance in hospitalized patients is not well characterized. Objectives The goal of this systematic literature review was to assess the performance of CDRs for PE in hospitalized patients. Methods We performed a structured literature search using Medline, EMBASE and the Cochrane library for articles published on or before January 18, 2017. Two authors reviewed all titles, abstracts and full texts...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#3
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044293/down-regulation-of-the-munc18b-syntaxin-11-complex-and-%C3%AE-1-tubulin-impairs-secretion-and-spreading-in-neonatal-platelets
#4
Eva Caparrós-Pérez, Raúl Teruel-Montoya, Verónica Palma-Barquero, José M Torregrosa, José E Blanco, Juan L Delgado, María Luisa Lozano, Vicente Vicente, Martha Sola-Visner, José Rivera, Constantino Martínez, Francisca Ferrer-Marín
Neonatal platelets are hyporeactive and show impaired agonist-induced secretion despite no obvious abnormalities in their granules. Here, we examined, for the first time, the ultrastructure of neonatal and adult platelets following agonist activation. Under resting conditions, neonatal and adult platelets appeared ultrastructurally identical. Following agonist stimulation, however, noticeable degranulation occurred in adult platelets, while granules in neonatal platelets remained clearly visible and apparently unable to centralize or fuse...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044292/investigation-of-the-filamin-a-dependent-mechanisms-of-tissue-factor-incorporation-into-microvesicles
#5
Mary Collier, Mary E W Collier, Camille Ettelaie, Benjamin T Goult, Anthony Maraveyas, Alison H Goodall
We have previously shown that phosphorylation of tissue factor (TF) at Ser253 increases the incorporation of TF into microvesicles (MVs) following protease-activated receptor 2 (PAR2) activation through a process involving filamin A, whereas phosphorylation of TF at Ser258 suppresses this process. Here, we examined the contribution of the individual phosphorylation of these serine residues to the interaction between filamin A and TF, and further examined how filamin A regulates the incorporation of TF into MVs...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044291/preprocedural-leucocyte-count-predicts-risk-in-patients-with-coronary-chronic-total-occlusion
#6
Catherine Gebhard, Aurel Toma, Zhao Min, Barbara E Stähli, Kambis Mashayekhi, Michael Gick, Miroslaw Ferenc, Heinz Joachim Büttner, Franz-Josef Neumann
Background As technologies of percutaneous coronary intervention (PCI) for coronary chronic total occlusions (CTO) have improved, great uncertainty exists regarding patient selection and long-term benefit of CTO-PCI. Given that white blood cell (WBC) count has been associated with cardiovascular risk, we hypothesized that the latter might provide incremental prognostic value in patients undergoing CTO-PCI. Methods and Results Our study population consisted of 1,262 consecutive patients (76.3% males, mean age of 67...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044290/protease-activated-receptor-par-4-an-inducible-switch-between-thrombosis-and-vascular-inflammation
#7
Anke C Fender, Bernhard H Rauch, Tobias Geisler, Karsten Schrör
Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncontrolled PAR activation, however, can prevent timely resolution of inflammation, enhance thrombogenic endothelial function and drive adverse remodelling. The specific role of PAR-4 in thromboinflammatory vascular disease has been largely underestimated, given the relatively limited expression of PAR-4 in non-platelet cells under healthy conditions...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044296/mitochondria-and-platelet-cell-death
#8
Andaleb Kholmukhamedov, Shawn Jobe
No abstract text is available yet for this article.
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981557/increasing-incidence-and-recurrence-rate-of-venous-thromboembolism-in-paediatric-oncology-patients-in-one-single-centre-over-25-years
#9
C Heleen Van Ommen, Irene L M Klaassen, Anne L van Els, Marianne D van de Wetering, C Heleen Van Ommen
Venous thromboembolism (VTE) is a serious complication in paediatric oncology patients. To identify the incidence, risk factors and recurrence rate of VTE in paediatric oncology patients, an observational, retrospective cohort study of all consecutive children (≦18 years) with malignancies, treated at the Emma Children's Hospital Academic Medical Centre between January 1989 and December 2013, was done. A matched case-control study in children with lymphomas was performed, to identify thrombotic risk factors...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981556/apixaban-auto-intoxication-toxicokinetics-and-coagulation-tests
#10
Lodi Mast, R J Verheul, R Reijnen, R C J M van Rossen, J W P M Overdiek, E B Wilms
No abstract text is available yet for this article.
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981555/platelets-contribute-to-the-accumulation-of-matrix-metalloproteinase-type-2-in-synovial-fluid-in-osteoarthritis
#11
Alessia Alunno, Emanuela Falcinelli, Filippo Luccioli, Eleonora Petito, Elena Bartoloni, Stefania Momi, Giulia Mirabelli, Giovanni B Mancini, Roberto Gerli, Paolo Gresele
Inflammation plays a role in the initiation and progression of osteoarthritis (OA), a chronic degenerative joint disorder. Platelets are inflammatory cells, contain and release matrix metalloproteinases (MMPs) and favour the release of these enzymes, key effectors of cartilage and subchondral bone degradation, by other cells; however, their role in OA has not been investigated yet. Our aims were (1) to assess the presence of platelets and of MMP-2 in synovial fluid (SF) of OA patients; (2) to evaluate the contribution of platelets to MMP-2 release by fibroblast-like synoviocytes (FLS); and (3) to investigate if hyaluronic acid (HA) interferes with these processes...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981554/extracellular-cyclophilin-a-augments-platelet-dependent-thrombosis-and-thromboinflammation
#12
Saskia N I V Ungern-Sternberg, Sebastian Vogel, Britta Walker-Allgaier, Sascha Geue, Andreas Maurer, Anna-Maria Wild, Patrick Münzer, Madhumita Chatterjee, David Heinzmann, Elisabeth Kremmer, Oliver Borst, Patricia Loughran, Alma Zernecke, Matthew D Neal, Timothy R Billiar, Meinrad Gawaz, Peter Seizer
Cyclophilin A (CyPA) is involved in the pathophysiology of several inflammatory and cardiovascular diseases. To our knowledge, there is no specific inhibitor targeting extracellular CyPA without affecting other extracellular cyclophilins or intracellular CyPA functions. In this study, we developed an antibody-based inhibitor of extracellular CyPA and analysed its effects in vitro and in vivo. To generate a specific antibody, mice and rats were immunized with a peptide containing the extracellular matrix metalloproteinase inducer binding site and various antibody clones were selected and purified...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981553/dabigatran-versus-warfarin-for-acute-venous-thromboembolism-in-elderly-or-impaired-renal-function-patients-pooled-analysis-of-re-cover-and-re-cover-ii-pooled-analysis-of-re-cover-and-re-cover-ii
#13
Samuel Z Goldhaber, Sam Schulman, Henry Eriksson, Martin Feuring, Mandy Fraessdorf, Jörg Kreuzer, Elke Schüler, Sebastian Schellong, Ajay K Kakkar
Management of acute venous thromboembolism (VTE) with anticoagulants in elderly patients and those with chronic kidney disease poses special challenges. The RE-COVER and RE-COVER II trials showed that dabigatran 150 mg twice daily was as effective as warfarin over 6 months in preventing recurrent VTE, with a lower bleeding risk. We now assess the effects of old age and renal impairment (RI) on pooled trial outcomes in 5,107 patients: 4,504 aged <75 years and 603 aged ≥75 years. The primary efficacy outcome was symptomatic VTE/VTE-related death...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28981552/vitamin-k-antagonists-compared-to-low-molecular-weight-heparins-for-treatment-of-cancer-associated-venous-thromboembolism-an-observational-study-in-routine-clinical-practice-an-observational-study-in-routine-clinical-practice
#14
Paul L den Exter, José Hooijer, Tom van der Hulle, Julien P van Oosten, Olaf M Dekkers, Frederikus A Klok, Menno V Huisman
Since several trials have demonstrated that low-molecular-weight-heparin (LMWH) is superior to vitamin K antagonist (VKA) in preventing recurrent venous thromboembolism (VTE) in patients with cancer-associated VTE, guidelines now recommend LMWH monotherapy in this setting. We evaluated whether this shift resulted in improved outcomes in routine clinical practice. We performed a cohort study of consecutive patients with cancer-associated VTE during 2001 and 2010. We compared the risks for recurrent VTE, major bleeding and mortality between patients diagnosed before and after 2008 during a 6-month routine follow-up...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28933799/rivaroxaban-for-preventing-venous-thromboembolism-in-high-risk-ambulatory-patients-with-cancer-rationale-and-design-of-the-cassini-trial-rationale-and-design-of-the-cassini-trial
#15
Alok Khorana, Saroj Vadhan-Raj, Nicole M Kuderer, Ted Wun, Howard Liebman, Gerald Soff, Chandra Belani, Eileen M O'Reilly, Robert McBane, John Eikelboom, C V Damaraju, Karen Beyers, Flavia Dietrich, Ajay K Kakkar, Hanno Riess, Renata D'Alpino Peixoto, Gary H Lyman
Venous thromboembolism (VTE) is a frequent complication of cancer associated with morbidity, mortality, increased hospitalizations and higher health care costs. Cancer patients at increased risk for VTE can be identified using a validated risk assessment score, and the incidence of VTE can be reduced in high-risk settings using anticoagulation. Rivaroxaban is a potent, oral, direct, factor Xa inhibitor approved for the prevention and treatment of thromboembolic events, including VTE. CASSINI is a double-blind, randomized, parallel-group, multicentre study comparing rivaroxaban with placebo in adult ambulatory patients with various cancers who are initiating systemic cancer therapy and are at high risk of VTE (Khorana score ≥ 2)...
September 21, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28933798/pharmacokinetics-of-tecarfarin-and-warfarin-in-patients-with-severe-chronic-kidney-disease
#16
Mark Midei, Detlef Albrecht, Mintu P Turakhia, Daniel Ries, Thomas Marbury, William Smith, Debbie Dillon, Peter G Milner, Mark G Midei
Chronic kidney disease (CKD) complicates warfarin anticoagulation partially through its effect on CYP2C9 activity. Tecarfarin, a novel vitamin K antagonist, is not metabolized by CYP2C9. To evaluate the effect of CKD on their metabolism, we measured PK parameters of warfarin and tecarfarin in subjects with and without CKD. CKD subjects with estimated glomerular filtration rate < 30 mL/min not on dialysis (n = 13) were matched to healthy volunteers (HVs) (n = 10). Each subject was randomized to either warfarin 10 mg or tecarfarin 30 mg and was later crossed over to the other drug...
September 21, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28933797/perivascular-perfusion-on-contrast-enhanced-ultrasound-ceus-is-associated-with-inflammation-in-patients-with-acute-deep-vein-thrombosis
#17
Mathias Kaspar, Stephan Imfeld, Sasan Partovi, Markus Aschwanden, Thomas Baldi, Alexander Dikkes, Deborah R Vogt, Dimitrios A Tsakiris, Daniel Staub
Background Inflammatory processes of the venous wall in acute deep vein thrombosis (DVT) play a role in thrombus formation and resolution. However, direct evaluation of the perivascular inflammation is currently not feasible. Objective To assess perivascular perfusion in acute proximal DVT using contrast-enhanced ultrasound (CEUS) reflecting perivenous inflammation and its association with systemic inflammatory markers in a single-centre, prospective observational study. Patients/Methods Twenty patients with proximal DVT underwent CEUS imaging in the thrombosed and contralateral popliteal vein at baseline and after 2 weeks and 3 months...
September 21, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28837210/derivation-and-validation-of-a-novel-bleeding-risk-score-for-elderly-patients-with-venous-thromboembolism-on-extended-anticoagulation
#18
Eva Seiler, Andreas Limacher, Marie Mean, Hans-Jürg Beer, Joseph Osterwalder, Beat Frauchiger, Marc Righini, Markus Aschwanden, Christian M Matter, Martin Banyai, Nils Kucher, Daniel Staub, Bernhard Lämmle, Nicolas Rodondi, Alessandro Squizzato, Drahomir Aujesky
Existing clinical scores do not perform well in predicting bleeding in elderly patients with acute venous thromboembolism (VTE). We sought to derive an easy-to-use clinical score to help physicians identify elderly patients with VTE who are at high-risk of bleeding during extended anticoagulation (>3 months). Our derivation sample included 743 patients aged ≥65 years with VTE who were enrolled in a prospective multicenter cohort study. All patients received extended anticoagulation with vitamin K antagonists...
August 24, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28956889/risk-stratification-with-the-dapt-score-carefully-read-the-instructions-and-use-as-intended
#19
Davide Capodanno
No abstract text is available yet for this article.
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28906543/the-role-of-atrial-fibrillation-in-patients-with-an-embolic-stroke-of-unknown-source-esus
#20
Rolf Wachter, Ben Freedman
No abstract text is available yet for this article.
October 5, 2017: Thrombosis and Haemostasis
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