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Thrombosis and Haemostasis

Daniela Pedicino, Ada Francesca Giglio, Aureliano Ruggio, Gianluca Massaro, Alessia D'Aiello, Francesco Trotta, Claudia Lucci, Francesca Graziani, Luigi Marzio Biasucci, Filippo Crea, Giovanna Liuzzo
Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability...
July 10, 2018: Thrombosis and Haemostasis
Luis J Serrano, Ana Cañete, Tamara Garcia-Leal, Laura Tomás-Gallardo, Ana I Flores, Paz de la Torre, Antonio Liras, María José Sánchez
The development of new strategies based on cell therapy approaches to correct haemophilia A (HA) requires further insights into new cell populations capable of producing coagulation factor VIII (FVIII) and presenting stable engraftment potential. The major producers of FVIII in the adult are liver sinusoidal endothelial cells (LSECs) and in a lesser degree bone marrow-derived cells, both of which have been shown to ameliorate the bleeding phenotype in adult HA mice after transplantation. We have previously shown that cells from the foetal liver (FL) and the aorta-gonads-mesonephros (AGM) haematopoietic locations possess higher LSEC engraftment potential in newborn mice compared with adult-derived LSECs, constituting likely therapeutic targets for the treatment of HA in neonates...
July 10, 2018: Thrombosis and Haemostasis
C E A Dronkers, G C Mol, G Maraziti, M A van de Ree, M V Huisman, C Becattini, F A Klok
BACKGROUND:  Post-thrombotic syndrome (PTS) is a common and potential severe complication of deep venous thrombosis (DVT). Elastic compression stocking therapy may prevent PTS if worn on a daily basis, but stockings are cumbersome to apply and uncomfortable to wear. Hence, identification of predictors of PTS may help physicians to select patients at high risk of PTS. AIMS:  This article identifies ultrasonography (US) parameters assessed during or after treatment of DVT of the leg, that predict PTS...
July 4, 2018: Thrombosis and Haemostasis
Christina Lind-Halldén, Eric Manderstedt, Daniel Carlberg, Stefan Lethagen, Christer Halldén
von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, for example, VWF , ABO and STXBP5 . Here, we comprehensively screen for STXBP5 variants and investigate their association with type 1 VWD in Swedish patients and controls. The coding region of the STXBP5 gene was re-sequenced in 107 type 1 VWD patients and the detected variants were genotyped in the type 1 VWD population and a Swedish control population (464 individuals)...
July 4, 2018: Thrombosis and Haemostasis
Eszter Palyu, Jolan Harsfalvi, Tamas Tornai, Maria Papp, Miklos Udvardy, Katalin Szekeres-Csiki, Lajos Pataki, Karen Vanhoorelbeke, Hendrik B Feys, Hans Deckmyn, Istvan Tornai
BACKGROUND:  There is an unstable balance between pro- and anti-haemostatic processes in patients with cirrhosis. We hypothesized, that in patients with acute decompensation (AD) the major alterations of von Willebrand factor (VWF) could contribute to the pro-thrombotic situation as compared to patients with stable (ST) cirrhosis. PATIENTS AND METHODS:  We analysed different parameters of VWF, including detailed multimer distribution by densitometry and platelet adhesion, together with <u>a</u><u>d</u>isintegrin-like <u>a</u>nd <u>m</u>etalloproteinase with <u>t</u>hrombo<u>s</u>pondin type-1 motifs <u>13</u> (ADAMTS13) activity and antigen and C-reactive protein (CRP) levels in patients with ST cirrhosis ( n  = 99), with AD ( n  = 54) and controls ( n  = 92)...
July 4, 2018: Thrombosis and Haemostasis
Khalil Ibrahim, Rohan Shah, Rakesh R Goli, Thomas S Kickler, William A Clarke, Rani K Hasan, Roger S Blumenthal, David R Thiemann, Jon R Resar, Steven P Schulman, John W McEvoy
Morphine delays oral P2Y12 platelet inhibitor absorption and is associated with adverse outcomes after myocardial infarction. Consequently, many physicians and first responders are now considering fentanyl as an alternative. We conducted a single-centre trial randomizing cardiac patients undergoing coronary angiography to intravenous fentanyl or not. All participants received local anaesthetic and intravenous midazolam. Those requiring percutaneous coronary intervention (PCI) with stenting received 180 mg oral ticagrelor intra-procedurally...
July 4, 2018: Thrombosis and Haemostasis
Geneviève A J C Crombag, Henri M Spronk, Patty Nelemans, Floris H B M Schreuder, Martine T B Truijman, Anouk C van Dijk, Alexandra A J de Rotte, Madieke I Liem, Mat J A P Daemen, Anton F W van der Steen, Werner H Mess, Paul J Nederkoorn, Jeroen Hendrikse, Aad van der Lugt, Joachim E Wildberger, Hugo Ten Cate, Robert J van Oostenbrugge, M Eline Kooi
BACKGROUND:  Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the relation between thrombin and plaque vulnerability. We hypothesize that decreased thrombin generation (TG) is associated with IPH and plaque vulnerability. OBJECTIVE:  This article investigates whether TG is associated with IPH and other features of plaque vulnerability in stroke patients...
July 4, 2018: Thrombosis and Haemostasis
Marie Méan, Andreas Limacher, Adriano Alatri, Drahomir Aujesky, Lucia Mazzolai
BACKGROUND:  Not all patients carry the same risk of developing a post-thrombotic syndrome (PTS), we therefore aimed to derive a prediction rule for risk stratification of PTS in patients with deep vein thrombosis (DVT). METHODS:  Our derivation sample included 276 patients with a first acute symptomatic lower limb DVT enrolled in a prospective cohort. We derived our prediction rule using regression analysis, with the occurrence of PTS within 24 months of a DVT based on the Villalta score as outcome, and 11 candidate variables as predictors...
June 30, 2018: Thrombosis and Haemostasis
Sanjay Khandelwal, Alexandra M Johnson, Jian Liu, David Keire, Cynthia Sommers, Joann Ravi, Grace M Lee, John D Lambris, Edimara S Reis, Gowthami M Arepally
No abstract text is available yet for this article.
June 30, 2018: Thrombosis and Haemostasis
Elodie Boissier, Steve Genebrier, Karim Lakhal, Fabienne Nedelec-Gac, Marc Trossaërt, Catherine Ternisien, Isabelle Gouin-Thibault
No abstract text is available yet for this article.
June 30, 2018: Thrombosis and Haemostasis
Satu Långström, Minna Koskenvuo, Pasi Huttunen, Riitta Lassila, Mervi Taskinen, Susanna Ranta, Markku Heikinheimo, Anne Mäkipernaa
Coagulation system is disturbed by several mechanisms after allogeneic haematopoietic stem cell transplantation (HSCT). We evaluated the effect of HSCT on coagulation system by various conventional and investigational methods in 30 children and adolescents who received HSCT due to haematological malignancies. Pro-thrombin fragment 1 + 2, a specific measure of thrombin generation, and von Willebrand factor, a measure of endothelial activation, increased after conditioning treatment, and remained elevated until 3 months after HSCT ( p  < 0...
June 30, 2018: Thrombosis and Haemostasis
Mehul R Chorawala, Prem Prakash, Prakash Doddapattar, Manish Jain, Nirav Dhanesha, Anil K Chauhan
BACKGROUND:  Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI). Very little is known about the role of Fn-EDA in the pathophysiology of acute MI under these co-morbid conditions. MATERIALS AND METHODS:  We determined the role of Fn-EDA in myocardial ischaemia/reperfusion (I/R) injury in the hyperlipidaemic apolipoprotein E-deficient (ApoE-/- ) mice...
June 30, 2018: Thrombosis and Haemostasis
R E G Schutgens, E R van Bladel, K Fischer, A Huisman, R T Urbanus
No abstract text is available yet for this article.
June 22, 2018: Thrombosis and Haemostasis
Jorien Claes, Bartosz Ditkowski, Laurens Liesenborghs, Tiago Rafael Veloso, Jose M Entenza, Philippe Moreillon, Thomas Vanassche, Peter Verhamme, Marc F Hoylaerts, Ruth Heying
Adhesion of Staphylococcus aureus to endothelial cells (ECs) is paramount in infective endocarditis. Bacterial proteins such as clumping factor A (ClfA) and fibronectin binding protein A (FnbpA) mediate adhesion to EC surface molecules and (sub)endothelial matrix proteins including fibrinogen (Fg), fibrin, fibronectin (Fn) and von Willebrand factor (vWF). We studied the influence of shear flow and plasma on the binding of ClfA and FnbpA (including its sub-domains A, A16+ , ABC, CD) to coverslip-coated vWF, Fg/fibrin, Fn or confluent ECs, making use of Lactococcus lactis , expressing these adhesins heterologously...
June 17, 2018: Thrombosis and Haemostasis
Neil A Zakai, Suzanne E Judd, Brett Kissela, George Howard, Monika M Safford, Mary Cushman
BACKGROUND:  Haemostatic balance represented by low protein C (PC) and elevated factor VIII (FVIII) has been inconsistently associated with stroke and coronary heart disease (CHD) risk. OBJECTIVE:  This article assesses whether an elevated FVIII and a low PC would increase cardiovascular risk more than either individually. PATIENTS AND METHODS:  REGARDS recruited 30,239 black and white U.S. participants aged ≥ 45 years between 2003 and 2007...
June 11, 2018: Thrombosis and Haemostasis
Jose Coelho-Lima, Ashfaq Mohammed, Suzanne Cormack, Samuel Jones, Rajiv Das, Mohaned Egred, Pedram Panahi, Simi Ali, Ioakim Spyridopoulos
BACKGROUND:  Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors (e.g. heparin) in patient blood samples have prevented reproducible miRNA quantification in this cohort and subsequent translation of these biomarkers to clinical practice...
June 11, 2018: Thrombosis and Haemostasis
Minjae Yoon, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung
BACKGROUND:  Stroke risk in atrial fibrillation (AF) is often assessed at initial presentation, and risk stratification performed as a 'one off'. In validation studies of risk prediction, baseline values are often used to 'predict' events that occur many years later. Many clinical variables have 'dynamic' changes over time, as the patient is followed up. These dynamic changes in risk factors may increase the CHA2 DS2 -VASc score, stroke risk category and absolute ischaemic stroke rate...
May 3, 2018: Thrombosis and Haemostasis
Tanya M Petterson, Carin Y Smith, Jane A Emerson, Kent R Bailey, Aneel A Ashrani, John A Heit, Cynthia L Leibson
Nursing home (NH) residency is an independent risk factor for venous thromboembolism (VTE), but the VTE burden within the NH population is uncertain. This study estimates VTE incidence and VTE-associated mortality among NH residents. We identified all NH residents in any NH in Olmsted County, Minnesota, United States, 1 October 1998 to 31 December 2005 and all first lifetime VTE among county residents to estimate VTE incidence while resident of local NHs (NHVTE), using Centers for Medicare and Medicaid Services Minimum Data Set and Rochester Epidemiology Project resources...
July 2018: Thrombosis and Haemostasis
Hugo Partsch
No abstract text is available yet for this article.
July 2018: Thrombosis and Haemostasis
Bob Siegerink
No abstract text is available yet for this article.
July 2018: Thrombosis and Haemostasis
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