journal
MENU ▼
Read by QxMD icon Read
search

Psychopharmacology

journal
https://www.readbyqxmd.com/read/28646451/regulation-of-sustained-attention-false-alarm-responding-and-implementation-of-conditional-rules-by-prefrontal-gabaa-transmission-comparison-with-nmda-transmission
#1
Meagan L Auger, Juliet Meccia, Stan B Floresco
RATIONALE: Both prefrontal cortex (PFC) GABAA and NMDA transmission regulate attentional processes, yet how they may differentially regulate signal detection or other aspects of attention is unclear. OBJECTIVES: We examined PFC GABAA and NMDA receptor regulation of attention using a sustained attention task (SAT) permitting identification of distinct forms of impairments. As this task requires implementation of conditional rules, we also investigated how reducing PFC GABA transmission affected performance of visual and auditory conditional discriminations...
June 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28634710/pharmacodynamic-and-pharmacokinetic-assessment-of-electronic-cigarettes-combustible-cigarettes-and-nicotine-gum-implications-for-abuse-liability
#2
Mitchell F Stiles, Leanne R Campbell, Donald W Graff, Bobbette A Jones, Reginald V Fant, Jack E Henningfield
RATIONALE: Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES: The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abuse liability comparator products (usual brand combustible cigarettes and nicotine gum, respectively) in a group of 45 EC-naïve smokers. METHODS: Enrolled subjects' ratings of subjective effects and nicotine uptake over 6 h were used to measure abuse liability and pharmacokinetics following in-clinic use of each EC...
June 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28631100/co-modulation-of-an-allosteric-modulator-of-nicotinic-receptor-cholinesterase-inhibitor-galantamine-and-a-5-ht4-receptor-agonist-rs-67333-effect-on-scopolamine-induced-memory-deficit-in-the-mouse
#3
Thomas Freret, Véronique Lelong-Boulouard, Pierre Lecouflet, Katia Hamidouche, François Dauphin, Michel Boulouard
AIM: It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin receptor (5-HT4R) partial agonist, RS-67333, to counterbalance deficits in short- and long-term memory. To select sub-efficacious doses of both drugs, dose-response studies were first performed on the scopolamine-induced deficits of spontaneous alternation in the Y-maze task and of acquisition and retrieval processes in a passive avoidance task...
June 19, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28631099/discontinuation-of-pharmacological-treatment-of-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-meta-analysis-of-63-studies-enrolling-11-788-patients
#4
M Riera, X Castells, A Tobias, R Cunill, L Blanco, D Capellà
BACKGROUND: The risk-benefit balance of pharmacological treatment for children and adolescents with ADHD and the factors that moderate this relationship are unclear. METHODS: A systematic review and meta-analysis of randomised, placebo-controlled clinical trials (RPCCTs) investigating the efficacy of pharmacological treatment in children or adolescents with ADHD was carried out. Meta-analysis of treatment discontinuation, clinician-, parent- and teacher-rated efficacy and adverse events was performed...
June 19, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28623385/juvenile-social-isolation-affects-maternal-care-in-rats-involvement-of-allopregnanolone
#5
Maria Giuseppina Pisu, Giorgia Boero, Francesca Biggio, Anna Garau, Daniela Corda, Mauro Congiu, Alessandra Concas, Patrizia Porcu, Mariangela Serra
RATIONALE: Social isolation of rats immediately after weaning is thought to represent an animal model of anxiety-like disorders. Socially isolated virgin females showed a significant decrease in allopregnanolone levels, associated with increased anxiety-related behavior compared with group-housed rats. OBJECTIVES: The present study investigates whether post-weaning social isolation affects maternal behavior and assesses neuroactive steroid levels in adult female rats during pregnancy and postpartum...
June 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28612134/ketamine-induced-behavioural-and-brain-oxidative-changes-in-mice-an-assessment-of-possible-beneficial-effects-of-zinc-as-mono-or-adjunct-therapy
#6
Olakunle James Onaolapo, Olayemi Quyyom Ademakinwa, Temitayo Opeyemi Olalekan, Adejoke Yetunde Onaolapo
RATIONALE: We studied the influence of zinc, haloperidol or olanzapine on neurobehaviour (open-field, radial arm maze and elevated plus maze) and brain antioxidant status in vehicle- or ketamine-treated mice, with the aim of ascertaining the potentials of zinc in counteracting ketamine's effects. OBJECTIVES: Experiment 1 assessed the effects of zinc in healthy animals and the relative degrees of modulation of ketamine's effects by zinc, haloperidol or olanzapine, respectively...
June 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28608008/effects-of-social-reorganization-on-dopamine-d2-d3-receptor-availability-and-cocaine-self-administration-in-male-cynomolgus-monkeys
#7
P W Czoty, R W Gould, H D Gage, M A Nader
RATIONALE: Studies have demonstrated that brain dopamine D2/D3 receptors (D2/D3R) and the reinforcing effects of cocaine can be influenced by a monkey's position in the social dominance hierarchy. OBJECTIVE: In this study, we manipulated the social ranks of monkeys by reorganizing social groups and assessed effects on D2/D3R availability and cocaine self-administration. METHODS: Male cynomolgus monkeys (N = 12) had been trained to self-administer cocaine under a concurrent cocaine-food reinforcement schedule...
June 12, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28601965/event-related-potentials-reflect-impaired-temporal-interval-learning-following-haloperidol-administration
#8
Sarah E Forster, Patrick Zirnheld, Anantha Shekhar, Stuart R Steinhauer, Brian F O'Donnell, William P Hetrick
BACKGROUND: Signals carried by the mesencephalic dopamine system and conveyed to anterior cingulate cortex are critically implicated in probabilistic reward learning and performance monitoring. A common evaluative mechanism purportedly subserves both functions, giving rise to homologous medial frontal negativities in feedback- and response-locked event-related brain potentials (the feedback-related negativity (FRN) and the error-related negativity (ERN), respectively), reflecting dopamine-dependent prediction error signals to unexpectedly negative events...
June 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28601964/choice-between-variable-and-fixed-cocaine-injections-in-male-rhesus-monkeys
#9
S L Huskinson, K B Freeman, N M Petry, J K Rowlett
RATIONALE: The schedule of drug availability may enhance choice of a drug. In non-human subjects, reinforcers are chosen more often when available under variable schedules of reinforcement relative to fixed schedules. OBJECTIVE: To determine whether variable-drug access is an important determinant of cocaine choice by manipulating the schedule, drug dose, and combination of schedule + dose. METHOD: Four male rhesus monkeys chose between cocaine doses (0...
June 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28600734/effects-of-varenicline-on-alcohol-cue-reactivity-in-heavy-drinkers
#10
Walter Roberts, Emily L R Harrison, Sherry A McKee
RATIONALE: Clinical trials and human laboratory studies have established that varenicline can reduce rates of alcohol use among heavy drinkers. Less is known about the mechanisms by which varenicline has this effect on drinking behavior. Reactivity to alcohol cues is often cited as the primary cause of relapse among those being treated for alcohol use disorder, and several front-line treatments for alcohol use disorder work, at least in part, by minimizing cue-induced alcohol craving...
June 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28593441/context-and-craving-during-stressful-events-in-the-daily-lives-of-drug-dependent-patients
#11
Kenzie L Preston, William J Kowalczyk, Karran A Phillips, Michelle L Jobes, Massoud Vahabzadeh, Jia-Ling Lin, Mustapha Mezghanni, David H Epstein
RATIONALE: Knowing how stress manifests in the lives of people with substance-use disorders could help inform mobile "just in time" treatment. OBJECTIVES: The purpose of this paper is to examine discrete episodes of stress, as distinct from the fluctuations in background stress assessed in most EMA studies. METHODS: For up to 16 weeks, outpatients on opioid-agonist treatment carried smartphones on which they initiated an entry whenever they experienced a stressful event (SE) and when randomly prompted (RP) three times daily...
June 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28589265/effects-of-ketamine-on-the-unconditioned-and-conditioned-locomotor-activity-of-preadolescent-and-adolescent-rats-impact-of-age-sex-and-drug-dose
#12
Sanders A McDougall, Andrea E Moran, Timothy J Baum, Matthew G Apodaca, Vanessa Real
RATIONALE: Ketamine is used by preadolescent and adolescent humans for licit and illicit purposes. OBJECTIVE: The goal of the present study was to determine the effects of acute and repeated ketamine treatment on the unconditioned behaviors and conditioned locomotor activity of preadolescent and adolescent rats. METHODS: To assess unconditioned behaviors, female and male rats were injected with ketamine (5-40 mg/kg), and distance traveled was measured on postnatal day (PD) 21-25 or PD 41-45...
June 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28589264/habitual-nicotine-seeking-in-rats-following-limited-training
#13
A Loughlin, D Funk, K Coen, A D Lê
RATIONALE AND OBJECTIVES: A potential reason that cigarette smoking can persist despite multiple quit attempts is that repeated voluntary nicotine intake may facilitate a transition from goal-directed to habitual behavioral control. Although accelerated habit formation for self-administered ethanol or cocaine has been previously demonstrated, this phenomenon has not been extensively studied with nicotine. We therefore examined the liability of nicotine self-administration to become habitual, while also examining that of orally consumed saccharin as an experimental control...
June 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28589263/assessment-of-tolerance-to-the-effects-of-methamphetamine-on-daytime-and-nighttime-activity-evaluated-with-actigraphy-in-rhesus-monkeys
#14
Laís F Berro, Monica L Andersen, Leonard L Howell
RATIONALE: Methamphetamine is one of the most largely consumed illicit drugs, and its use is associated with abuse liability and several adverse health effects, such as sleep impairment. Importantly, sleep quality can influence addiction treatment outcomes. Evidence suggests that tolerance can develop to the sleep-disrupting effects of stimulant drugs. OBJECTIVE: The aim of the present study was to investigate the development of tolerance to the actigraphy-based sleep-disrupting and stimulant effects of methamphetamine self-administration in rhesus monkeys...
June 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28584929/steep-effort-discounting-of-a-preferred-reward-over-a-freely-available-option-in-prolonged-methamphetamine-withdrawal-in-male-rats
#15
Andrew B Thompson, Julian Gerson, Alexandra Stolyarova, Amador Bugarin, Evan E Hart, J David Jentsch, Alicia Izquierdo
RATIONALE: Drug addiction can be described as aberrant allocation of effort toward acquiring drug, despite associated costs. It is unclear if this behavioral pattern results from an overvaluation of reward or to an altered sensitivity to costs. OBJECTIVE: Present experiments assessed reward sensitivity and effortful choice in rats following 1 week of withdrawal from methamphetamine (mAMPH). METHODS: Rats were treated with either saline or an escalating dose mAMPH regimen, then tested after a week without the drug...
June 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28584928/effects-of-the-serotonin-2c-receptor-agonist-way163909-on-the-abuse-related-effects-and-mesolimbic-dopamine-neurochemistry-induced-by-abused-stimulants-in-rhesus-monkeys
#16
Laís F Berro, Maylen Perez Diaz, Eric Maltbie, Leonard L Howell
RATIONALE: Accumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse. OBJECTIVE: The aim of the present study was to evaluate the effects of the selective serotonin 5-HT2C receptor agonist WAY163909 on the behavioral neuropharmacology of cocaine and methamphetamine in adult rhesus macaques...
June 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28567699/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-respiratory-depressant-effects-of-oxycodone-modeling-an-abuse-deterrent-opioid-analgesic-in-rats
#17
E Andrew Townsend, Jennifer E Naylor, S Stevens Negus, Shelley R Edwards, Hina N Qureshi, Hunter W McLendon, Christopher R McCurdy, Coco N Kapanda, Jussara M do Carmo, Fernanda S da Silva, John E Hall, Kenneth J Sufka, Kevin B Freeman
RATIONALE: Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional kappa agonists is limited by their dysphoric side effects. OBJECTIVES: The current study examined the effects of nalfurafine, a clinically available atypical kappa agonist, on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone in male rats...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28567698/incidence-and-risk-factors-of-acute-akathisia-in-493-individuals-with-first-episode-non-affective-psychosis-a-6-week-randomised-study-of-antipsychotic-treatment
#18
Maria Juncal-Ruiz, Mariluz Ramirez-Bonilla, Jorge Gomez-Arnau, Victor Ortiz-Garcia de la Foz, Paula Suarez-Pinilla, Obdulia Martinez-Garcia, Karl David Neergaard, Rafael Tabares-Seisdedos, Benedicto Crespo-Facorro
INTRODUCTION: Acute akathisia is a neuropsychiatric syndrome with a negative effect on illness outcome. Its incidence in patients treated with antipsychotics has shown to be highly variable across studies. OBJECTIVES: Our goals were to investigate prevalence, risk factors for the development of acute akathisia, and differences in incidence between antipsychotics in a sample of 493 first episode non-affective psychosis patients. METHODS: This is a pooled analysis of three prospective, randomized, flexible-dose, and open-label clinical trials...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28567697/dopaminergic-mechanisms-in-memory-consolidation-and-antidepressant-reversal-of-a-chronic-mild-stress-induced-cognitive-impairment
#19
Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Ewa Litwa, Monika Niemczyk, Katarzyna Tota-Glowczyk, Paul Willner
Cognitive deficits in depression can be modelled using the novel object recognition (NOR) test, performance in which is impaired by chronic mild stress (CMS). We aimed to examine the involvement of mesocorticolimbic DA terminal regions, and to establish the substrate for CMS-induced impairment of NOR and its reversal by chronic antidepressant treatment. In experiments 1 and 2, we examined the effect of infusions into medial PFC, dorsal hippocampus (HPC), and nucleus accumbens (NAc) shell of D1 and D2 antagonists and D3 agonist, which were predicted to impair NOR with a short (1 h) delay, and of D1 and D2 agonists and D3 antagonist, which were predicted to facilitate NOR with a long (24 h) delay...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28567696/blunted-stress-reactivity-in-chronic-cannabis-users
#20
Carrie Cuttler, Alexander Spradlin, Amy T Nusbaum, Paul Whitney, John M Hinson, Ryan J McLaughlin
RATIONALE: One of the most commonly cited reasons for chronic cannabis use is to cope with stress. Consistent with this, cannabis users have shown reduced emotional arousal and dampened stress reactivity in response to negative imagery. OBJECTIVES: To our knowledge, the present study represents the first to examine the effects of an acute stress manipulation on subjective stress and salivary cortisol in chronic cannabis users compared to non-users. METHODS: Forty cannabis users and 42 non-users were randomly assigned to complete either the stress or no stress conditions of the Maastricht Acute Stress Test (MAST)...
May 31, 2017: Psychopharmacology
journal
journal
26754
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"