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Clinical Neuropharmacology

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https://www.readbyqxmd.com/read/29432287/allergy-to-carbidopa
#1
Mariana Aurora Cansino-Torres, Valeria Sandoval-Rodríguez, Michel Sáenz-Farret, Carlos Zúñiga-Ramírez
BACKGROUND: D-Decarboxylase inhibitors, such as carbidopa or benserazide, have been used as adjunct therapy in Parkinson disease shortly after levodopa synthesis in the 1960s. These compounds increase intracerebral drug concentration and decrease adverse effects by blocking peripheral conversion to dopamine. Skin rash as part of an allergic reaction was previously described in subjects who were using levodopa in combination with carbidopa or benserazide; however, etiology was never clear...
February 9, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29432286/effect-of-concomitant-medications-on-the-safety-and-efficacy-of-extended-release-carbidopa-levodopa-ipx066-in-patients-with-advanced-parkinson-disease-a-post-hoc-analysis
#2
Peter A LeWitt, Leo Verhagen Metman, Robert Rubens, Sarita Khanna, Sherron Kell, Suneel Gupta
OBJECTIVES: Extended-release (ER) carbidopa-levodopa (CD-LD) (IPX066/RYTARY/NUMIENT) produces improvements in "off" time, "on" time without troublesome dyskinesia, and Unified Parkinson Disease Rating Scale scores compared with immediate-release (IR) CD-LD or IR CD-LD plus entacapone (CLE). Post hoc analyses of 2 ER CD-LD phase 3 trials evaluated whether the efficacy and safety of ER CD-LD relative to the respective active comparators were altered by concomitant medications (dopaminergic agonists, monoamine oxidase B [MAO-B] inhibitors, or amantadine)...
February 9, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29432285/a-well-tolerated-and-effective-antiepileptic-drug-for-patients-with-myasthenia-gravis-at-last
#3
José Manuel Sánchez-Villalobos, Irene Villegas-Martínez, José Antonio Pérez-Vicente
Antiepileptic drugs have been known to worsen myasthenia gravis (MG) symptoms, and therefore, in patients who suffer both conditions (myasthenia and epilepsy), treatment selection is difficult. We report 2 cases of patients with MG who were safely treated with lacosamide. Evidence about antiepileptic drug treatment and adverse effects in MG is reviewed.
February 9, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29401068/camptocormia-induced-by-a-dopaminergic-agonist
#4
Tomoo Mano
Camptocormia, a condition that involves the abnormal flexion of the trunk and results in a forward-bending posture, is relatively common during the course of Parkinson disease (PD). Despite this, there is ongoing controversy concerning its mechanisms and no consensus regarding the underlying etiology. This report demonstrates a case in which a dopaminergic agonist (DA) was implicated in the onset of camptocormia episodes in a non-PD patient who developed camptocormia after the start of DA treatment. Over a course of 8 years, the patient experienced intermittent camptocormia, which resulted in multiple falls...
February 2, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29389745/safety-and-efficacy-of-rituximab-experience-of-a-single-multiple-sclerosis-center
#5
Brett Alldredge, Allison Jordan, Jaime Imitola, Michael K Racke
OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. B cells play an important pathogenic role in MS. Rituximab (RTX), a B-cell depleting drug, has been used to treat MS and neuromyelitis optica (NMO). Patient characteristics, safety, and efficacy measures are reviewed to ascertain the therapeutic benefit and safety of RTX in a real-world setting with long-term follow-up. METHODS: This is a retrospective chart review of patients who received RTX at The Ohio State University's MS clinic from January 2005 to October 2016...
January 31, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29303800/prescribing-trends-of-atypical-antipsychotic-drugs-in-an-outpatient-unit-of-a-child-and-adolescent-clinic-in-turkey
#6
Çiğdem Yektaş, Ali Evren Tufan
OBJECTIVE: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics. METHOD: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment...
January 5, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29300206/carbamazepine-treatment-of-hyperactivity-and-intrusiveness-in-dementia
#7
Jonathan T Stewart
Behavioral problems are seen in most patients with dementia and are often poorly characterized in the literature. We present a 70-year-old man with advanced Alzheimer disease and problematic disinhibited behaviors, including intrusiveness and Witzelsucht (disinhibited humor). These symptoms responded robustly to carbamazepine. Carbamazepine may be a useful adjunct in managing problematic behaviors in dementia, especially when those problems can be framed as behavioral disinhibition.
January 3, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29300205/effect-of-pharmacist-led-interventions-on-non-motor-symptoms-medication-related-problems-and-quality-of-life-in-parkinson-disease-patients-a-pilot-study
#8
Clementine Stuijt, Fatma Karapinar-Çarkit, Bart van den Bemt, Teus van Laar
INTRODUCTION: Patients with Parkinson disease (PD) use multiple drugs. This pill burden with consequent poor adherence may cause worsening of motor symptoms and drug-related problems. Therefore, a multifaceted pharmacist-led intervention program was designed to improve adherence, motor-functioning, and quality of life (QoL) in PD patients. METHODS: This prospective pilot study was performed in an outpatient PD clinic, where usual care was compared with stepwise introduction of 3 interventions: unit dose packaging (UDP), Parkinson KinetiGraph (PKG), and pharmacist-led medication review (MR)...
January 3, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29300204/the-association-between-the-severity-and-level-of-understanding-of-depression-among-patients-treated-with-antidepressants-a-survey-of-424-outpatients-in-japan
#9
Tetsu Tomita, Norio Yasui-Furukori, Shuhei Kudo, Norio Sugawara, Akira Fujii, Koji Tsuruga, Yasushi Sato, Masamichi Ishioka, Kazuhiko Nakamura
OBJECTIVES: The present study investigated the association between the severity and knowledge of depression and attempted to reveal the specific aspects of understanding associated with severity. METHODS: A total of 424 outpatients were enrolled in this study. We used an original self-administered questionnaire: (a) the symptoms of depression, (b) the course of depression, (c) the cause of depression, (d) the treatment plan, (e) the duration of antidepressant use, (f) how to discontinue antidepressant use, (g) the adverse effects of antidepressants, and (h) psychotherapy...
January 3, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29194113/anger-assessment-in-patients-treated-with-brivaracetam
#10
Gemma Ortega, Laura Abraira, Glòria Martí, Manuel Quintana, Gonzalo Mazuela, Estevo Santamarina, Xavier Salas-Puig, Manuel Toledo
OBJECTIVES: To assess state and trait anger, adjusted by epilepsy type, seizure control, anxiety-depression status and quality of life, in patients treated with brivaracetam (BRV) from an open study. METHODS: We evaluated prospectively consecutive patients with partial onset seizures in an open-label study. Patients had 5 years or longer of epilepsy and were taking between 1 and 3 antiepileptic drugs. They were treated with BRV and compared with a control group selected from outpatients attending our epilepsy unit who met the following criteria: age ≥16 years and diagnosis of epilepsy with focal-onset seizures at least 1 year before inclusion in the study...
December 1, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29194112/drug-associated-spontaneous-orgasm-a-case-report-and-systematic-review-of-literature
#11
Wei-Hsi Chen, Yuan-Hsiang Chu, Kuo-Yen Chen
OBJECTIVES: Spontaneous orgasm is characterized by a spontaneous onset of orgasm without any preceding sexual or nonsexual trigger. It sheds insight on the mechanisms underlying orgasms and the sexual response cycle in humans. METHODS: We report a male patient of repetitive spontaneous orgasm under trazodone treatment and systematically review the literature on drug-associated spontaneous orgasm (DASO). RESULTS: A total of 25 patients (18 women and 7 men), including our reported case, experienced 27 DASO events...
December 1, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29194111/comment-on-selective-serotonin-reuptake-inhibitor-induced-hyponatremia-clinical-implications-and-therapeutic-alternatives
#12
Mehmet Ali Eren, Tevfik Sabuncu
No abstract text is available yet for this article.
December 1, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29194110/one-year-retention-study-of-adjunctive-perampanel-treatment-in-epilepsy-patients
#13
Dong Wook Kim, Jeeyoung Oh
OBJECTIVES: Perampanel is a recently introduced antiepileptic drug (AED) with a unique action mechanism of noncompetitive and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist. Because of delayed approval of perampanel in most Asian countries, there is limited information on the clinical usefulness of perampanel in the Asian population. We performed a retrospective analysis of retention rate, seizure outcome, and adverse events for perampanel treatment in South Korea...
December 1, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29303801/intravenous-valproic-acid-add-on-therapy-in-acute-agitation-adolescents-with-suspected-substance-abuse-a-report-of-six-cases
#14
Claudia Battaglia, Roberto Averna, Milena Labonia, Assia Riccioni, Stefano Vicari
The aim of this study was to test efficacy and safety of intravenous (IV) valproate for aggression in children and adolescents with mood or conduct disorder and concomitant substance abuse. Six patients received a 20 mg/kg dose of IV valproic acid as an add-on therapy to their standard therapy with second-generation antipsychotics and benzodiazepines. Agitation and general psychopathology were measured at baseline and after the first injection using the Modified Overt Aggression Scale, the Brief Psychiatric Rating Scale, and the Children's Global Assessment Scale...
January 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29303799/open-access-electronic-diary-for-motor-fluctuation-and-dyskinesia-evaluation-in-parkinson-disease-comparison-with-paper-diary
#15
Cinthia Terroba-Chambi, Veronica Bruno, Alex Medina-Escobar, Federico Nanni, Daniel Cerquetti, Malco Rossi, Marcelo Merello
OBJECTIVE: To determine the utility of an electronic diary for registering motor fluctuations and dyskinesia in Parkinson disease (PD). METHODS: Free, open-access touch screen software suitable for Android 4.4 or higher, with medication alarms, adjustable intervals, and medication dose settings was developed to evaluate ON-OFF periods and dyskinesia. Prospective evaluation included a first phase conducted to make adjustments concerning motor limitations when using the tablet, as well as for proper motor complication identification, and a second phase of 3 days of use at home with a prior diary training session comparing a modified paper version of Core Assessment Program for Surgical Interventional Therapies in PD and the electronic diary...
January 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29298167/newly-developed-skin-picking-after-methylphenidate-treatment-in-attention-deficit-hyperactivity-disorder-possible-mechanisms
#16
Tayfun Kara, İsmail Akaltun
Dermatillomania is characterized by excessive and repeated skin picking sufficient to damage cutaneous tissue, but with no underlying dermatological disease. The condition appears as an independent diagnosis in the Obsessive-Compulsive and Related Disorders category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. A psychiatric pathology is generally reported to accompany this symptom. Attention deficit hyperactivity disorder (ADHD) is a potentially lifelong condition involving inattentiveness, hyperactivity, and impulsiveness...
January 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29059136/successful-use-of-escitalopram-for-the-treatment-of-visual-hallucinations-in-patients-with-parkinson-disease
#17
Joseph Bergman, Paul P Lerner, Shmuel Sokolik, Vladimir Lerner, Anatoly Kreinin, Chanoch Miodownik
INTRODUCTION: Patients with Parkinson disease (PD) frequently experience visual hallucinations (VH). Visual hallucinations are most often viewed as an adverse effect of antiparkinsonian treatment. Possible treatments for this disturbance include a reduction of antiparkinsonian medications, adding atypical antipsychotics, or cholinesterase inhibitors. Some studies demonstrated that selective serotonin reuptake inhibitors may be an optional treatment for patients experiencing psychosis or agitation in dementia...
November 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29059135/pramipexole-and-electroconvulsive-therapy-in-treatment-resistant-depression
#18
Claire Gauthier, Lama Souaiby, Emmanuelle Advenier-Iakovlev, Raphaël Gaillard
BACKGROUND: Major depressive disorder (MDD) is a common disease. Despite appropriate antidepressant treatment, approximately one third of patients do not achieve adequate response. In these patients, electroconvulsive therapy (ECT) is a possible option. Nevertheless, some symptoms may persist even after ECT. METHOD: This is a comparative retrospective study assessing the efficacy and safety of pramipexole in the treatment of resistant depression, in combination to ECT or after a partial ECT efficacy...
November 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29059134/aripiprazole-for-post-traumatic-stress-disorder-a-systematic-review
#19
Sara R Britnell, Anna D Jackson, Jamie N Brown, Bruce P Capehart
OBJECTIVE: The aim of this study was to review the safety and efficacy of aripiprazole as monotherapy and adjunct therapy for the treatment of post-traumatic stress disorder (PTSD). METHODS: A search of both MEDLINE (1956 to May 2017) and EMBASE (1957 to May 2017) was conducted using the terms "aripiprazole" and "post-traumatic stress disorder," "posttraumatic stress disorder," or "PTSD." Studies evaluating the primary endpoint of PTSD in patients taking aripiprazole as monotherapy or adjunct therapy were analyzed for relevance...
November 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29059133/a-phase-ib-randomized-controlled-study-to-evaluate-the-effectiveness-of-a-single-dose-of-the-nr2b-selective-n-methyl-d-aspartate-antagonist-mk-0657-on-levodopa-induced-dyskinesias-and-motor-symptoms-in-patients-with-parkinson-disease
#20
W Joseph Herring, Christopher Assaid, Kerry Budd, Ryan Vargo, Ralph S Mazenko, Christopher Lines, Aaron Ellenbogen, Leo Verhagen Metman
OBJECTIVES: Blockade of N-methyl-D-aspartate receptors containing the NR2B subunit has been shown to be therapeutic in animal models of Parkinson disease (PD). However, findings with investigational NR2B receptor antagonists in PD patients have been mixed. The objective of this study was to evaluate the effects of the NR2B selective N-methyl-D-aspartate receptor antagonist MK-0657 on levodopa-induced dyskinesias and motor symptoms in PD patients. METHODS: A randomized, double-blind, single-dose, 2-period crossover study was conducted in 22 patients with PD and levodopa-induced peak-dose dyskinesias...
November 2017: Clinical Neuropharmacology
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