journal
MENU ▼
Read by QxMD icon Read
search

Clinical Neuropharmacology

journal
https://www.readbyqxmd.com/read/28277445/thrombolytic-therapy-in-wake-up-stroke-patients
#1
Gretchen M Stern, Nicholas Van Hise, Lindsay M Urben, Matthew J Korobey, Jamie M Pitlick, Andrew J Crannage
OBJECTIVE: The aim of the study is to review existing and ongoing trial data on wake-up stroke (WUS) patients for thrombolytic therapy. METHODS: A literature search was conducted in PubMed (conception-October 2016) using the terms wake-up stroke, acute ischemic stroke, wake-up thrombolysis, computed tomography imaging in wake-up stroke, and magnetic resonance imaging in wake-up stroke. Ongoing trials were found using the ClinicalTrials.gov website. RESULTS: The search yielded 61 articles in PubMed and 7 ongoing trials...
March 9, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28277444/bilateral-retrobulbar-optic-neuropathy-associated-with-golimumab
#2
Marta de Frutos-Lezaun, Aritz Bidaguren, Patricia de la Riva, Carlos F Meneses, Javier Olascoaga
We report the first documented case of retrobulbar optic neuropathy associated with golimumab. A 48-year-old man was admitted with a 3-week history of progressive visual loss of his left eye. He had received a second infusion of golimumab for ankylosing spondylitis 10 days before admission. A magnetic resonance imaging scan showed enhancement of both optic nerves and visual evoked potentials were consistent with demyelinating bilateral optic neuropathy, although visual acuity drop in the right eye could not be determined because of deep amblyopia...
March 9, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28277443/sugarcoated-perineuronal-nets-regulate-gabaergic-transmission-bittersweet-hypothesis-in-autism-spectrum-disorder
#3
Jessica A Burket, Maria R Urbano, Stephen I Deutsch
Fast-spiking, parvalbumin-expressing "GABAergic" interneurons regulate synchronous oscillatory output of pyramidal neurons. Metabolic demands of these GABAergic projections are great because local ion concentrations must be optimally maintained; in addition, high rates of mitochondrial respiration necessitate exquisite redox regulation. Interestingly, only fast-spiking, parvalbumin-expressing basket cells coexpressing 3 metalloproteinases seem to be preferentially enwrapped in perineuronal nets (PNNs), a specialized lattice-like structure of the extracellular matrix...
March 9, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28277442/divergence-palsy-due-to-divalproex-and-oxcarbazepine
#4
Marc Albert Bouffard, Louis R Caplan, Nurhan Torun
OBJECTIVE: This case series is the first to describe divergence palsy as an adverse effect of antiepileptic drug use. Diplopia is a common adverse effect of antiepileptic drugs, but no explanatory motility deficit has ever been reported. METHODS: We present 2 patients, 1 on oxcarbazepine and 1 on divalproex, each with a normal examination result between spells and divergency palsy when symptomatic. RESULTS: Discontinuation of the antiepileptic medication led to resolution of the episodes in both cases...
March 9, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28288483/efficacy-of-treatments-for-infantile-spasms-a-systematic-review
#5
Ji Min Song, Jongsung Hahn, Se Hee Kim, Min Jung Chang
OBJECTIVES: West syndrome (also known as infantile spasm because of its main seizure type) is a rare form of epilepsy that begins during early infancy. Recent guidelines and reviews on West syndrome recommend the use of adrenocorticotropic hormone steroids, or vigabatrin, as the first-line treatment. However, West syndrome remains to be one of the most challenging epilepsies to treat. Here, we systematically reviewed the current literature obtained during the previous decade. This article provides an overview of the current treatment of infantile spasms...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28288482/a-multicenter-comparative-study-of-impulse-control-disorder-in-latin-american-patients-with-parkinson-disease
#6
Carolina Candelaria Ramírez Gómez, Marcos Serrano Dueñas, Oscar Bernal, Natalia Araoz, Michel Sáenz Farret, Victoria Aldinio, Verónica Montilla, Federico Micheli
OBJECTIVES: Impulse control disorder (ICD) is a common adverse effect in patients with Parkinson disease who receive dopamine agonists; however, other factors are involved in its manifestations. To study the frequency and factors involved in the development of this adverse effect in a Latin American population, we conducted a cross-sectional multicenter study. METHODS: Two hundred fifty-five patients in 3 Latin American centers were evaluated by examination and application of scales (Unified Parkinson's Disease Rating Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale, Hoehn and Yahr, Clinical Impression of Severity Index for Parkinson's Disease)...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28225385/two-cases-of-oral-somatic-delusions-ameliorated-with-brain-perfusion-asymmetry-a-case-report
#7
Yojiro Umezaki, Akihito Uezato, Akira Toriihara, Toru Nishikawa, Akira Toyofuku
BACKGROUND: Oral cenesthopathy is the complaint of abnormal oral sensation where no underlying organic cause can be identified. It is also called oral dysesthesia or oral somatic delusion and classified as delusional disorder, somatic type. The patients with oral cenesthopathy show right > left asymmetric regional cerebral blood flow (rCBF) in the broad brain region. However, the studies scrutinizing the rCBF change before and after the successful treatment are still a few so far. CASE: We present 2 cases of oral cenesthopathy, who responded well to aripiprazole...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28195839/carbamazepine-toxicity-induced-spindle-coma-a-novel-case-report
#8
Bhumir Chauhan, Amitkumar Patanvadiya, Gopal Krishna Dash
A 9-year-old girl presented with alleged history of deliberate ingestion of 4 g of carbamazepine, following which she became comatose. A bedside electroencephalogram (EEG) was performed to rule out nonconvulsive status epilepticus, which showed presence of spindle coma (SC), not reactive to noxious stimuli. Following hemodialysis, a second EEG showed absence of SC and complete clinical recovery. We present this unique case of carbamazepine-induced SC, thereby highlighting the extent of the etiologic spectrum of SC and discussing the literature related to this association...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28195838/the-use-of-zonisamide-for-the-treatment-of-psychiatric-disorders-a-systematic-review
#9
Massimiliano Buoli, Silvia Grassi, Valentina Ciappolino, Marta Serati, Alfredo C Altamura
OBJECTIVE: Traditional pharmacotherapy has undoubtedly improved the outcome of patients with psychiatric disorders, but partial efficacy or poor tolerability persists in a number of these subjects. Among different compounds, zonisamide has been used to address unmet needs of standard pharmacotherapy. The purpose of the present article is to provide a review about the use of zonisamide for the treatment of psychiatric conditions. METHODS: A research in the main database sources has been conducted to obtain an overview of the use of zonisamide in psychiatric disorders or associated conditions (obesity and smoking cessation)...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28195837/the-effect-of-atomoxetin-use-in-the-treatment-of-attention-deficit-hyperactivity-disorder-on-the-symptoms-of-restless-legs-syndrome-a-case-report
#10
Saliha Baykal, Melih Nuri Karakurt
Attention-deficit/hyperactivity disorder (ADHD) is frequently accompanied with sleep disorders such as obstructive sleep apnea, periodic limb movement disorder, restless legs syndrome (RLS), and circadian rhythm disorder. We have limited information about the effects of medical therapies used in the treatment of ADHD on RLS. This article discusses the effects of atomoxetine treatment on both disorders in a patient followed by diagnoses of ADHD and RLS.
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28118168/increased-trichotillomania-symptoms-in-a-child-with-fluoxetine-treatment
#11
Çiğdem Yektaş, Ali Evren Tufan
Trichotillomania (TTM) is a mental disorder characterized by uncontrolled and impulsive hair pulling leading to hair loss, distress, and disordered functioning. Treatment choices include behavioral therapy (especially habit reversal training) and selective serotonin reuptake inhibitors. However, randomized controlled trials conducted with selective serotonin reuptake inhibitors have led to controversial results of effectiveness for TTM. Here, we report a female patient whose TTM symptoms increased after fluoxetine use...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28118167/three-year-retention-rates-of-levetiracetam-topiramate-and-oxcarbazepine-a-retrospective-hospital-based-study
#12
Jun-Sang Sunwoo, Byeong-Su Park, Seon Jae Ahn, Sungeun Hwang, Chan-Young Park, Jin-Sun Jun, Dong Wook Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Ki-Young Jung, Sang Kun Lee
OBJECTIVES: We evaluated and compared the 3-year retention rates of levetiracetam (LEV), topiramate (TPM), and oxcarbazepine (OXC) in patients with epilepsy in routine clinical practice. METHODS: We retrospectively reviewed medical records of patients with epilepsy who were newly prescribed LEV, TPM, or OXC from 2006 to 2010. The retention rates were estimated by the Kaplan-Meier analysis, and independent risk factors for drug discontinuation were analyzed by the Cox regression method...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28085707/citicoline-combination-therapy-for-major-depressive-disorder-a-randomized-double-blind-placebo-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Mahtab Roohi-Azizi, Somaye Arabzadeh, Meysam Amidfar, Samrand Salimi, Mohammad Reza Zarindast, Ali Talaei, Shahin Akhondzadeh
OBJECTIVE: Residual symptoms of major depressive disorder are a source of long-term morbidity. New therapeutic strategies are required to alleviate this morbidity and enhance patient quality of life. Citicoline has been used for vascular accidents and has been effective in cognitive rehabilitation. It has been used successfully to reduce craving in patients with substance abuse disorder and for mood management of bipolar disorder. Here, we test citicoline effectiveness as an adjuvant therapy in major depression...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941528/efficacy-of-the-treatments-used-in-multiple-sclerosis-from-meta-analysis-to-number-needed-to-treat
#14
Antonio J García-Ruiz, Guillermo Izquierdo-Ayuso, Guillermo Navarro-Mascarell, Ana C Montesinos-Gálvez, Francisco Martos-Crespo, Francisco Jódar-Sánchez, Manuel Correa, Nuria García-Agua Soler
The aim of this study was to analyze the efficacy of drugs used in relapsing-remitting multiple sclerosis, first- and second-line drugs, using the number needed to treat (NNT) as a measure of efficacy. METHODS: Data from randomized clinical trials were analyzed for 3 categories of clinical efficacy outcomes: relapse, change in Expanded Disability Status Scale, and number of new lesions in magnetic resonance imaging. Meta-analysis results are expressed as odds ratios. RESULTS: The global odds ratio was 0...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941527/striatal-dopamine-transporter-modulation-after-rotigotine-results-from-a-pilot-single-photon-emission-computed-tomography-study-in-a-group-of-early-stage-parkinson-disease-patients
#15
Carlo Rossi, Dario Genovesi, Paolo Marzullo, Assuero Giorgetti, Elena Filidei, Giovanni Umberto Corsini, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Several in vitro data have reported negative interference by dopamine-agonists on the expression of dopamine transporter (DAT), whereas the majority of imaging studies have shown that neither L-dopa nor dopamine-agonists interfere with DAT availability. As yet, there are no in vivo studies on DAT expression after treatment with rotigotine. METHODS: We evaluated presynaptic nigrostriatal function in 8 patients with de novo Parkinson disease (age, 59 ± 6...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941526/epigallocatechin-gallate-extends-therapeutic-window-of-recombinant-tissue-plasminogen-activator-treatment-for-brain-ischemic-stroke-a-randomized-double-blind-and-placebo-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Xue-Hui Wang, Yi-Ping You
OBJECTIVES: Recombinant tissue plasminogen activator (rt-PA) is a safe and effective treatment for acute brain ischemia stroke, albeit with a narrow therapeutic window. We aimed to assess the effect of epigallocatechin gallate (EGCG) in extending the rt-PA treatment window in this clinical trial among stroke patients. METHODS: Patients were randomly assigned according to their onset-to-treatment time (OTT) and were then treated with rt-PA simultaneously with EGCG or placebo...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941525/alcohol-sensitive-generalized-dystonia
#17
Federico Micheli, Claudia Uribe-Roca, Michel Saenz-Farret
We report the case of a 29-year-old male patient with a generalized and progressive dystonia that led him unable to stand. Multiple antidystonic treatments were tried without benefit. Alcohol test was positive with a dramatic improvement. To the best of our knowledge, this is the first reported case of generalized dystonia without other clinical manifestations sensitive to alcohol.
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27879551/no-superiority-of-treatment-with-osmotic-controlled-release-oral-delivery-system-methylphenidate-over-short-medium-acting-methylphenidate-preparations-in-the-rate-and-timing-of-injuries-in-children-with-attention-deficit-hyperactivity-disorder
#18
Pavel Golubchik, Arad Kodesh, Abraham Weizman
OBJECTIVES: Methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD) is reported to reduce the risk for injuries. In the present study, the rate and timing of injuries were compared among the various MPH preparations (4 and 6-8 vs 12 hour-acting) in children with ADHD. METHODS: This real-world retrospective study covered the years 2011 to 2013. Participants included 2042 youngsters (aged 4-18 years, 13.01 ± 3.2 years; 71...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27879550/successful-treatment-of-brachial-plexopathy-due-to-herpes-zoster-infection-with-intravenous-immunoglobulin
#19
Michel Sáenz-Farret, Valeria Sandoval-Rodríguez, Claudia Esther Paz-Navarro, Carlos Zúñiga-Ramírez
OBJECTIVE: The aim of this study was to report the case of a male patient with Parkinson disease who developed brachial plexopathy (BP) due to varicella-zoster virus, which was successfully treated with human immunoglobulin. METHOD: We report the case of a 75-year-old male subject with a diagnosis of Parkinson disease who came to our hospital complaining of pain, skin lesions, and strength loss in his right arm during the past 2 months. Physical examination revealed vesicular rash compatible with varicella-zoster virus lesions...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27879549/fingolimod-use-for-the-treatment-of-multiple-sclerosis-in-a-clinical-practice-setting-in-madrid
#20
Victoria Galán Sánchez-Seco, Ignacio Casanova-Peño, Roberto Álvarez-Lafuente, Mónica Sánchez-Jiménez, Ángel García-Martínez, María Inmaculada Domínguez-Mozo, Ana María Arias-Leal, Marta García-Montojo, Rafael Arroyo-González
OBJECTIVE: To assess the effectiveness and safety of fingolimod use in a Spanish clinical practice setting. METHODS: Retrospective study with multiple sclerosis patients who received at least 1 fingolimod dose between January 2004 and January 2015. Effectiveness and safety data were collected during the entire treatment of each patient. Analysis was performed for the total population and stratified according to prior treatment, sex, and age at treatment initiation...
January 2017: Clinical Neuropharmacology
journal
journal
26752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"