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Archives of Pathology & Laboratory Medicine

Andrew A Renshaw, Edwin W Gould
CONTEXT: -The College of American Pathologists requires synoptic reports for specific types of pathology reports. OBJECTIVE: -To compare the accuracy and speed of information retrieval in synoptic reports of different formats. DESIGN: -We assessed the performance of 28 nonpathologists from 4 different types of users (cancer registrars, MDs, medical non-MDs, and nonmedical) at identifying specific information in various formatted synoptic reports, using a computerized quiz that measured both accuracy and speed...
January 5, 2017: Archives of Pathology & Laboratory Medicine
Xulei Liu, Michael Kinzler, Jiangfan Yuan, Guozhong He, Lanjing Zhang
CONTEXT: -Little is known regarding the reporting quality of meta-analyses in diagnostic pathology. OBJECTIVE: -To compare reporting quality of meta-analyses in diagnostic pathology and medicine and to examine factors associated with reporting quality of diagnostic pathology meta-analyses. DESIGN: -Meta-analyses were identified in 12 major diagnostic pathology journals without specifying years and 4 major medicine journals in 2006 and 2011 using PubMed...
January 5, 2017: Archives of Pathology & Laboratory Medicine
Shiyong Li, David L Jaye, Kyle T Bradley, Linsheng Zhang, Debra Saxe, George Deeb, Charlie E Hill, Karen P Mann
Accurate assessment of tissues for hematolymphoid neoplasms requires an integrated multiparameter approach. Although morphologic examination by light microscopy remains the mainstay of initial assessment for hematolymphoid neoplasms, immunophenotypic analysis by immunohistochemistry and/or flow cytometry is essential to determine the pattern of differentiation and to detect minimal disease when morphology is inconclusive. In some cases, immunophenotypic analysis provides additional information for targeted immunotherapy and prognostication...
January 5, 2017: Archives of Pathology & Laboratory Medicine
Michelle D Reid, Melinda M Lewis, Field F Willingham, Volkan Adsay
Pancreatobiliary tract lesions are increasingly being discovered because of more sensitive imaging modalities. Magnetic resonance imaging has identified incidental pancreatic cysts in 13.5% of patients of progressively increasing age. Pancreatobiliary tissue is more accessible through endoscopic ultrasound and magnetic resonance imaging-guided biopsy procedures, and is now an integral part of pathologists' routine practice. Accordingly, several new tumor categories have been recently recognized, including intraductal tubulopapillary neoplasm, a new addition to tumoral intraepithelial neoplasms...
January 5, 2017: Archives of Pathology & Laboratory Medicine
Richard E Horowitz, Sarah M Bean
No abstract text is available yet for this article.
December 28, 2016: Archives of Pathology & Laboratory Medicine
Robert L Schmidt, Deborah J Chute, Jorie M Colbert-Getz, Adolfo Firpo-Betancourt, Daniel S James, Julie K Karp, Douglas C Miller, Danny A Milner, Kristi J Smock, Ann T Sutton, Brandon S Walker, Kristie L White, Andrew R Wilson, Eva M Wojcik, Marwan A Yared, Rachel E Factor
CONTEXT: - Statistical literacy can be defined as understanding the statistical tests and terminology needed for the design, analysis, and conclusions of original research or laboratory testing. Little is known about the statistical literacy of clinical or anatomic pathologists. OBJECTIVE: - To determine the statistical methods most commonly used in pathology studies from the literature and to assess familiarity and knowledge level of these statistical tests by pathology residents and practicing pathologists...
December 13, 2016: Archives of Pathology & Laboratory Medicine
Elizabeth D Euscher
Extragonadal germ cell tumors are uncommon, and although they morphologically resemble their gonadal counterparts, unexpected gonadal presentation increases the potential for erroneous diagnoses. Yolk sac tumor is a malignant germ cell tumor characterized by an extraembryonic yolk sac line of differentiation, and relative to other germ cell tumors, is characterized by varied and diverse histologic patterns. When occurring outside of typical age parameters or in extragonadal locations, the histologic variability of yolk sac tumor and its tendency to mimic somatic tumors pose diagnostic challenges...
December 13, 2016: Archives of Pathology & Laboratory Medicine
Ling Hui, Katherine B Geiersbach, Erinn Downs-Kelly, H Evin Gulbahce
CONTEXT: - In 2013 the American Society of Clinical Oncology and College of American Pathologists updated the HER2 guidelines and changed the equivocal category for HER2 in situ hybridization testing to an average HER2 copy number of 4.0 to 5.9 with a HER2:CEP17 ratio of less than 2.0 and proposed retesting, with an option of using another control probe to avoid false-negative results. RAI1, located at band position 17p11.2, is a popular alternate probe locus for retesting equivocal changes...
December 13, 2016: Archives of Pathology & Laboratory Medicine
Beth T Harrison, Deborah A Dillon, Andrea L Richardson, Jane E Brock, Anthony J Guidi, Susan C Lester
CONTEXT: - A review of amended pathology reports provides valuable information regarding defects in the surgical pathology process. OBJECTIVE: - To review amended breast pathology reports with emphasis placed on interpretative errors and their mechanisms of detection. DESIGN: - All amended pathology reports for breast surgical specimens for a 5-year period at a large academic medical center were retrospectively identified and classified based on an established taxonomy...
December 13, 2016: Archives of Pathology & Laboratory Medicine
Sanja Dacic
CONTEXT: -The International Association for the Study of Lung Cancer Staging Committee has prospectively created an international lung cancer database that was used to address many lung cancer staging questions, such as tumor size, nodal status, and metastatic disease. The proposed changes for the upcoming 8th edition of the cancer staging manual were based on survival data and better prognostic stratification of patients with lung cancer. OBJECTIVES: -To review published recommendations for the revision of lung carcinoma TNM staging and to address potential challenges in pathologic staging...
November 28, 2016: Archives of Pathology & Laboratory Medicine
Anja C Roden, Dara L Aisner, Timothy C Allen, Marie Christine Aubry, Roberto J Barrios, Mary B Beasley, Philip T Cagle, Vera L Capelozzi, Sanja Dacic, Yimin Ge, Lida P Hariri, Sylvie Lantuejoul, Ross A Miller, Mari Mino-Kenudson, Andre L Moreira, Kirtee Raparia, Natasha Rekhtman, Lynette Sholl, Maxwell L Smith, Ming S Tsao, Marina Vivero, Yasushi Yatabe, Eunhee S Yi
CONTEXT: - The diagnosis and grading of acute cellular and antibody-mediated rejection (AMR) in lung allograft biopsies is important because rejection can lead to acute graft dysfunction and/or failure and may contribute to chronic graft failure. While acute cellular rejection is well defined histologically, no reproducible specific features of AMR are currently identified. Therefore, a combination of clinical features, serology, histopathology, and immunologic findings is suggested for the diagnosis of AMR...
November 7, 2016: Archives of Pathology & Laboratory Medicine
Sanghui Park, So Young Kang, Ghee Young Kwon, Ji Eun Kwon, Sang Kyum Kim, Ji Yeon Kim, Chul Hwan Kim, Hyun-Jung Kim, Kyung Chul Moon, Ju Yeon Pyo, Won Young Park, Eun Su Park, Ji-Youn Sung, Sun Hee Sung, Young-Ha Oh, Seung Eun Lee, Wonae Lee, Jong Im Lee, Nam Hoon Cho, Soo Jin Jung, Min-Sun Cho, Yong Mee Cho, Hyun Yee Cho, Eun Jung Cha, Yang-Seok Chae, Gheeyoung Choe, Yeong Jin Choi, Jooryung Huh, Jae Y Ro
CONTEXT: - Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clinicopathologic characteristics of SDH-deficient tumors have not been fully studied. OBJECTIVE: - To define the clinicopathologic and molecular characteristics of PBPGs. DESIGN: - A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed...
November 7, 2016: Archives of Pathology & Laboratory Medicine
M Cristina Pacheco, Robyn C Reed
CONTEXT: -Autopsy is an important tool for quality assurance and improving patient care. Fetal, perinatal, and pediatric autopsies have the additional benefit of identifying conditions that may have increased risk of recurrence. In contrast to adult autopsies, special collections and testing are frequently used. Pathologist effort in fetal, perinatal, and pediatric autopsy has not been well documented. OBJECTIVE: -To prospectively quantify pathologist time required to complete fetal, perinatal, and pediatric autopsies, and to gather information on special studies and whether or not a cause of death was identified...
October 27, 2016: Archives of Pathology & Laboratory Medicine
David Altree-Tacha, Jillian Tyrrell, Thomas Haas
CONTEXT: -CDH17, which is expressed in the intestinal epithelium, is a novel oncogene involved in tumor invasion and metastasis. A panel consisting of cytokeratin (CK) 7, CD20, and CDX2 antibodies is typically used to diagnose gastrointestinal adenocarcinomas. However, studies have shown that CDH17 is a highly specific marker for gastrointestinal adenocarcinoma and may be important in clinical diagnosis. OBJECTIVE: -To evaluate the sensitivity and specificity of CDH17, CK20, and CDX2 antibodies in neoplastic tissues, with emphasis on colon, stomach, and esophageal gastrointestinal lineage...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Alain C Borczuk
CONTEXT: -The use of frozen section in thoracic pathology includes assessment of peripheral lung lesions with lepidic pattern, with greater emphasis on evaluating lung-sparing resections and margin assessment. OBJECTIVE: -To review pitfalls of frozen section in thoracic pathology; in this setting, reduction of false-positive and false-negative diagnosis in lesion identification and margin assessment is critical. DATA SOURCES: -PubMed search of frozen section lung pathology yielded specific references related to the use of frozen section in the identification of lepidic lesions and the clinical recommendation for margin distance...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Vijayalakshmi Padmanabhan, Heather B Steinmetz, Elizabeth J Rizzo, Amber J Erskine, Tamara L Fairbank, Francine B de Abreu, Gregory J Tsongalis, Laura J Tafe
CONTEXT: -At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core biopsy lung cancer samples. Two years ago the molecular diagnostics laboratory at our institution changed to next-generation sequencing using the Ion Torrent PGM and the 50-gene AmpliSeq Cancer Hotspot Panel v2 for analyzing mutations in a 50-gene cancer hot spot panel. This was associated with in a dramatic fall in adequacy rate (68%)...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Raul S Gonzalez, Sadiq M Amer, Nejib Ben Yahia, Felipe D'Almeida Costa, Manu Noatay, Jian-Hua Qiao, Flavia G Rosado, Yale Rosen, Bruno Tavares Sedassari, Rhonda K Yantiss, Jerad M Gardner
CONTEXT: -Facebook (Menlo Park, California) is one of many online sites that provide potential educational tools for pathologists. We have each founded Facebook groups dedicated to anatomic pathology, in which members can share cases, ask questions, and contribute to discussions. OBJECTIVES: -To report our experiences in founding and maintaining these Facebook groups and to characterize the contributed content. DESIGN: -We circulated a survey among the group founders, then compiled and analyzed the responses...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Ronald E Domen, Kristen Johnson, Richard Michael Conran, Robert D Hoffman, Miriam D Post, Jacob J Steinberg, Mark D Brissette, Dita A Gratzinger, Cindy B McCloskey, Patricia M Raciti, Cory Anthony Roberts, Amyn M Rojiani, Suzanne Zein-Eldin Powell
CONTEXT: -Professionalism issues in residency training can be difficult to assess and manage. Generational or role-based differences may also exist between faculty and residents as to what constitutes unprofessional behavior and how to manage it. OBJECTIVE: -To examine and compare how faculty and residents would approach the same 5 case scenarios detailing various aspects of unprofessional behavior. DESIGN: -Five case scenarios highlighting various unprofessional behaviors were presented in a workshop at an annual meeting of pathology department chairs, residency program directors, and undergraduate pathology medical educators (ie, pathologists involved in medical student pathology education)...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Carolin A Boecking, Eleanor A Drey, Jennifer L Kerns, Walter E Finkbeiner
CONTEXT: -Despite increased use of dilation and evacuation in the setting of fetuses with developmental anomalies, the pathology examination of fragmented specimens obtained by this technique has been understudied. OBJECTIVES: -To correlate pathologic findings in second-trimester fetal dilation and evacuation specimens with prenatal diagnoses established through ultrasound and/or chromosome studies to determine the value of pathology examination for supplementing or correcting clinical diagnoses...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Emily Jane Woo, Megha Kaushal
No abstract text is available yet for this article.
January 2017: Archives of Pathology & Laboratory Medicine
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