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Archives of Pathology & Laboratory Medicine

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https://www.readbyqxmd.com/read/29775074/recent-changes-of-classification-for-squamous-intraepithelial-lesions-of-the-head-and-neck
#1
Kyung-Ja Cho, Joon Seon Song
CONTEXT: - Interpretation of atypical squamous lesions of the head and neck has always been a nettlesome task for pathologists. Moreover, many different grading systems for squamous intraepithelial lesions have been proposed in past decades. The recent World Health Organization 2017 classification presents 2 types of 2-tier systems for laryngeal and oral precursor lesions. OBJECTIVE: - To review the recent changes in classification and the clinical significance for squamous intraepithelial lesions of the head and neck...
May 18, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29775073/diffuse-gliomas-for-nonneuropathologists-the-new-integrated-molecular-diagnostics
#2
Sunhee C Lee
Diffuse gliomas comprise the bulk of "brain cancer" in adults. The recent update to the 4th edition of the World Health Organization's classification of tumors of the central nervous system reflects an unprecedented change in the landscape of the diagnosis and management of diffuse gliomas that will affect all those involved in the management and care of patients. Of the recently discovered gene alterations, mutations in the Krebs cycle enzymes isocitrate dehydrogenases (IDHs) 1 and 2 have fundamentally changed the way the gliomas are understood and classified...
May 18, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29733682/maude-abbott-and-the-origin-and-mysterious-disappearance-of-the-canadian-medical-war-museum
#3
James R Wright, Samuel J M M Alberti, Christopher Lyons, Richard S Fraser
CONTEXT: - In the early 1900s, it was common practice to retain, prepare, and display instructive pathologic specimens to teach pathology to medical trainees and practitioners; these collections were called medical museums. Maude Abbott established her reputation by developing expertise in all aspects of medical museum work. She was a founder of the International Association of Medical Museums (later renamed the International Academy of Pathology) and became an internationally renowned expert on congenital heart disease...
May 7, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29733681/comparative-performance-of-breast-cancer-human-epidermal-growth-factor-receptor-2-fluorescence-in-situ-hybridization-and-brightfield-in-situ-hybridization-on-college-of-american-pathologists-proficiency-tests
#4
Katherine B Geiersbach, Julia A Bridge, Michelle Dolan, Lawrence J Jennings, Diane L Persons, Rhona J Souers, Karen D Tsuchiya, Patricia H Vasalos, Joel T Moncur
CONTEXT: - Fluorescence in situ hybridization (FISH) and brightfield in situ hybridization (ISH) are 2 clinically approved laboratory methods for detecting ERBB2 (HER2) amplification in breast cancer. OBJECTIVE: - To compare the performance of FISH and brightfield ISH on proficiency testing administered by the College of American Pathologists Laboratory Accreditation Program Design.- Retrospective review was performed on 70 tissue core samples in 7 separate proficiency testing surveys conducted between 2009 and 2013...
May 7, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29708429/us-food-and-drug-administration-approval-of-whole-slide-imaging-for-primary-diagnosis-a-key-milestone-is-reached-and-new-questions-are-raised
#5
Andrew J Evans, Thomas W Bauer, Marilyn M Bui, Toby C Cornish, Helena Duncan, Eric F Glassy, Jason Hipp, Robert S McGee, Doug Murphy, Charles Myers, Dennis G O'Neill, Anil V Parwani, B Alan Rampy, Mohamed E Salama, Liron Pantanowitz
April 12, 2017, marked a significant day in the evolution of digital pathology in the United States, when the US Food and Drug Administration announced its approval of the Philips IntelliSite Pathology Solution for primary diagnosis in surgical pathology. Although this event is expected to facilitate more widespread adoption of whole slide imaging for clinical applications in the United States, it also raises a number of questions as to the means by which pathologists might choose to incorporate this technology into their clinical practice...
April 30, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29708428/interpathologist-diagnostic-agreement-for-non-small-cell-lung-carcinomas-using-current-and-recent-classifications
#6
William K Funkhouser, D Neil Hayes, Dominic T Moore, W Keith Funkhouser, Jason P Fine, HeeJoon Jo, Nana Nikolaishvilli-Feinberg, Mervi Eeva, Juneko E Grilley-Olson, Peter M Banks, Paolo Graziano, Elizabeth L Boswell, Goran Elmberger, Kirtee Raparia, Craig F Hart, Lynette M Sholl, Norris J Nolan, Karen J Fritchie, Ersie Pouagare, Timothy C Allen, Keith E Volmar, Paul W Biddinger, Daniel T Kleven, Michael J Papez, Deborah V Spencer, Natasha Rekhtman, Mari Mino-Kenudson, Lida Hariri, Brandon Driver, Philip T Cagle
CONTEXT: - Measurement of interpathologist diagnostic agreement (IPDA) should allow pathologists to improve current diagnostic criteria and disease classifications. OBJECTIVES: - To determine how IPDA for pathologists' diagnoses of non-small cell lung carcinoma (NSCLC) is affected by the addition of a set of mucin and immunohistochemical (IHC) stains to hematoxylin-eosin (H&E) alone, by recent NSCLC reclassifications, by simplification of these classifications, and by pathologists' practice location, pulmonary pathology expertise, practice duration, and lung carcinoma case exposure...
April 30, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29697276/comparison-of-cytopathologist-performed-ultrasound-guided-fine-needle-aspiration-with-cytopathologist-performed-palpation-guided-fine-needle-aspiration-a-single-institutional-experience
#7
Rachel Conrad, Sung-Eun Yang, Shelley Chang, Meenakshi Bhasin, Peggy S Sullivan, Neda A Moatamed, David Y Lu
CONTEXT: - Although fine-needle aspiration (FNA) practice by pathologists is now well established, it has been primarily performed by manual palpation. In recent years, pathologists have begun to venture into ultrasound-guided FNAs (UGFNAs). Reports on experiences with this relatively new technique for pathologists have shown promising results. However to date, there have been few studies in the literature comparing pathologist-performed UGFNA with the more traditional pathologist-performed palpation-guided FNA (PGFNA)...
April 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29697275/use-of-the-national-institutes-of-health-consensus-guidelines-improves-the-diagnostic-sensitivity-of-gastrointestinal-graft-versus-host-disease
#8
Diana M Cardona, Claire J Detweiler, Michael J Shealy, Anthony D Sung, Daniel M Wild, Martin H Poleski, Bryan L Balmadrid, Constance T Cirrincione, David N Howell, Keith M Sullivan
CONTEXT: - Graft-versus-host disease of the gastrointestinal tract is a common complication of hematopoietic stem cell transplant associated with significant morbidity and mortality. Accurate diagnosis can be difficult and is a truly clinicopathologic endeavor. OBJECTIVES: - To assess the diagnostic sensitivity of gastrointestinal graft-versus-host disease using the 2015 National Institutes of Health (NIH) histology consensus guidelines and to analyze histologic findings that support the guidelines...
April 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29688032/setting-up-an-epathology-service-at-cleveland-clinic-abu-dhabi-joint-collaboration-with-cleveland-clinic-united-states
#9
Ayoub Nahal, Crystal Mildred O Batac, Renee J Slaw, Thomas W Bauer
CONTEXT: - The production of whole slide images is the most advanced form of digital pathology, in which a high-resolution digital scanner is used to rapidly scan glass microscope slides and produce a computer-generated whole slide image that can be saved, stored in a network-attached storage device, and accessed through slide management software within the hospital domain and remotely by authorized users. Digital transformation of glass slides has revolutionized the practice of anatomic pathology by facilitating and expediting consultative services, improving clinical workflow, and becoming an indispensable tool in education and research...
April 24, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29688031/gynecologic-serous-carcinoma-an-immunohistochemical-analysis-of-malignant-body-fluid-specimens
#10
Shuyue Ren, William Klump
CONTEXT: - Evaluation of fluid specimens involved by serous carcinoma might potentially include PAX8, GATA3, Uroplakin II, SOX2, and SALL4 antibodies. Those markers are commonly employed for diagnosing carcinomas of various types, including urothelial malignancies and germ cell tumors. There have been no comprehensive immunohistochemical studies, to our knowledge, for those markers on fluid specimens involved by serous carcinoma. OBJECTIVE: - To evaluate immunohistochemical markers PAX8, GATA3, SOX2, uroplakin II, and SALL4 in the diagnosis of high-grade serous carcinoma in fluid specimens...
April 24, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#11
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29652189/a-review-and-update-on-papillary-immature-metaplasia-of-the-uterine-cervix-a-distinct-subset-of-low-grade-squamous-intraepithelial-lesion-proposing-a-possible-cell-of-origin
#12
Soon Auck Hong, Su Hyun Yoo, Jene Choi, Stanley J Robboy, Kyu-Rae Kim
CONTEXT: - Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papilloma virus (LR-HPV). OBJECTIVE: - To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumptive cell of origin. DESIGN: - A total of 26 PIM cases were evaluated by p16INK4a , cytokeratin (CK) 7, and CK17 immunohistochemical stainings. Human papilloma virus genotyping was performed, by using HPV DNA Chip, HPV polymerase chain reaction (PCR), and real-time PCR...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29648887/molecular-testing-for-stage-iv-non-small-cell-lung-cancer-patients-with-targetable-mutations-following-disease-progression
#13
Ashish Saxena
No abstract text is available yet for this article.
April 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29648886/braf-adds-an-additional-piece-of-the-puzzle-to-precision-oncology-based-treatment-strategies-in-lung-cancer
#14
David Planchard, Bruce E Johnson
No abstract text is available yet for this article.
April 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29648885/commentary-on-testing-of-non-adenocarcinomas
#15
Natasha Rekhtman
No abstract text is available yet for this article.
April 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29624078/the-effect-of-3-2-and-3-8-sodium-citrate-on-specialized-coagulation-tests
#16
Franz Ratzinger, Mona Lang, Sabine Belik, Klaus G Schmetterer, Helmuth Haslacher, Thomas Perkmann, Peter Quehenberger
CONTEXT: - Coagulation testing is challenging and depends on preanalytic factors, including the citrate buffer concentration used. OBJECTIVE: - To better estimate preanalytic effects of the citrate buffer concentration in use, the difference between results obtained by samples with 3.2% and 3.8% citrate was evaluated. DESIGN: - In a prospective observational study with 76 volunteers, differences related to the citrate concentration were evaluated...
April 6, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29624077/molecular-testing-in-lung-cancer-where-to-draw-the-line
#17
Balazs Halmos
No abstract text is available yet for this article.
April 6, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29624076/performance-characteristics-of-cerebrospinal-fluid-cytology-an-analysis-of-responses-from-the-college-of-american-pathologists-nongynecologic-cytopathology-education-program
#18
Z Laura Tabatabai, Manon Auger, Rhona J Souers, Lisa Teot, Diane D Davey
CONTEXT: - Cerebrospinal fluid cytology is a critical diagnostic tool for the diagnosis of many conditions affecting the central nervous system. OBJECTIVE: - To assess the performance characteristics of cerebrospinal fluid cytology samples by evaluating participant interpretations within the College of American Pathologists' Nongynecologic Cytopathology Education program. DESIGN: - Participant interpretations (N = 46‚ÄČ264) evaluated in the College of American Pathologists' Nongynecologic Cytopathology Education Program were examined for concordance with the general category and with the reference diagnosis...
April 6, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29624075/molecular-testing-for-early-lung-cancer
#19
Nasser K Altorki
No abstract text is available yet for this article.
April 6, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29607664/cell-free-dna-utility-and-value-of-recommendation
#20
Benjamin Levy
No abstract text is available yet for this article.
April 2, 2018: Archives of Pathology & Laboratory Medicine
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