Ayman Alzu'bi, Worood Bani Baker, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Manal Isam AbuAlArjah, Ejlal Abu-El-Rub, Lena Tahat, Ahmed Mnz Helaly, Doaa S Ghorab, Waseem El-Huneidi, Raed M Al-Zoubi
PURPOSE: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model. METHODS: Adult male Balb/c mice were chronically treated with low (0...
February 28, 2024: Brain Research Bulletin