journal
MENU ▼
Read by QxMD icon Read
search

Neuroscience

journal
https://www.readbyqxmd.com/read/28629848/a-novel-intrinsic-electroretinogram-response-in-isolated-mouse-retina
#1
Motoharu Takao, Yumi Fukuda, Takeshi Morita
Since the discovery of intrinsic photosensitive retinal ganglion cell (ipRGC) was reported in 2002, many features specific to this cell type have been described. However, scare information is available on the retinographic components directly reflecting ipRGC activity. In this study, we identified the electroretinogram (microERG) that reflects the photoresponses by ipRGCs in ex vivo preparations of the mouse retina, in which classical photoreceptors (cones and rods) were ablated mechanically and photochemically...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28629847/evidence-for-m2-muscarinic-receptor-modulation-of-axon-terminals-and-dendrites-in-the-rodent-basolateral-amygdala-an-ultrastructural-and-electrophysiological-analysis
#2
Ana Fajardo-Serrano, Lei Liu, David D Mott, Alexander J McDonald
The basolateral amygdala receives a very dense cholinergic innervation from the basal forebrain that is important for memory consolidation. Although behavioral studies have shown that both M1 and M2 muscarinic receptors are critical for these mnemonic functions, there have been very few neuroanatomical and electrophysiological investigations of the localization and function of different types of muscarinic receptors in the amygdala. In the present study we investigated the subcellular localization of M2 muscarinic receptors (M2Rs) in the anterior basolateral nucleus (BLa) of the mouse, including the localization of M2Rs in parvalbumin (PV) immunoreactive interneurons, using double-labeling immunoelectron microscopy...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28629846/hippocampal-gr-and-cb1-mediated-mglur5-differentially-produces-susceptibility-and-resilience-to-acute-and-chronic-mild-stress-in-rats
#3
Hongli Sun, Rujuan Su, Xiaoxiao Zhang, Jun Wen, Dan Yao, Xinru Gao, Zhongliang Zhu, Hui Li
The molecular mechanism of individual response of susceptibility and resilience under psychological stress remains controversial and unclear. The present study aimed to explore the relationship of metabotropic glutamate receptor 5 (mGluR5) with glucocorticoid receptor (GR) or cannabinoid receptor (CB1) and further indicate the molecular mechanism of susceptibility and resilience to acute stress (AS) and chronic mild stress (CMS). Sucrose preference test and open field test were used to evaluate the response of susceptibility and resilience under stress in rats...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28629845/role-of-primary-motor-cortex-in-the-control-of-manual-dexterity-assessed-via-sequential-bilateral-lesion-in-the-adult-macaque-monkey-a-case-study
#4
Julie Savidan, Mélanie Kaeser, Abderraouf Belhaj-Saïf, Eric Schmidlin, Eric M Rouiller
From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) "modified Brinkman board" task, assessed simple precision grip versus complex precision grip, the latter involved a hand postural adjustment; (ii) "modified Klüver board" task, assessed movements ranging from power grip to precision grip, pre-shaping and grasping...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28625893/investigation-of-the-influence-of-emotions-on-working-memory-capacity-using-erp-and-ersp
#5
Yuanyuan Zhang, Gaoyan Zhang, Baolin Liu
Recent studies have reported that there are individual differences in working memory (WM), and that WM may be affected by emotions. To date, it remains controversial whether emotions impair or facilitate WM and whether there are individual differences in their effect on WM. In this study, three emotions (negative, neutral, and positive) were induced by a video database that was established according to the emotional stimuli habit of Chinese people. A change detection paradigm was used to examine the effect of emotions on the visual WM...
June 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627417/regulation-of-primary-motor-cortex-excitability-by-repetitive-passive-finger-movement-frequency
#6
Ryoki Sasaki, Masaki Nakagawa, Shota Tsuiki, Shota Miyaguchi, Sho Kojima, Kei Saito, Yasuto Inukai, Mitsuhiro Masaki, Naofumi Otsuru, Hideaki Onishi
Somatosensory input induced by passive movement activates primary motor cortex (M1). We applied repetitive passive movement (RPM) of different frequencies to test if modulation of M1 excitability depends on RPM frequency. Twenty-seven healthy subjects participated in this study. Motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) to left M1 were recorded from the right first dorsal interosseous muscle (FDI) to assess corticospinal excitability (experiment 1: n=15), and F-waves were measured from the right FDI as an index of spinal motoneuron excitability (experiment 2: n=15)...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28624573/plasticity-of-intrinsic-firing-response-gain-in-principal-hippocampal-neurons-following-pilocarpine-induced-status-epilepticus
#7
Idit Tamir, Moshe Daninos, Yoel Yaari
OBJECTIVE: In experimental models of temporal lobe epilepsy (TLE), brain neurons manifest multiple changes in intrinsic excitability that contribute to neuronal network hyperexcitability. We have investigated whether the intrinsic firing response gain, quantified by the slope of the function relating the number of evoked spikes (Ns) to input excitatory current intensity (I), is modified in principal rat hippocampal neurons in the pilocarpine-status epilepticus (SE) model of TLE. METHODS: Intracellular recordings were made in CA3 and CA1 pyramidal cells (PCs) and dentate granule cells (GCs) in acute hippocampal slices obtained 7-36 days after pilocarpine-SE...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28624572/role-of-beta-catenin-and-endocannabinoids-in-the-nucleus-accumbens-in-extinction-in-rats-exposed-to-shock-and-reminders
#8
Nachshon Korem, Rachel Lange, Cecilia J Hillard, Irit Akirav
The response to a traumatic experience may be rapid recovery or development of psychopathology such as posttraumatic stress disorder (PTSD). Impaired extinction of fear memories is thought to contribute to the development of the persistent trauma memories and avoidance. The Wnt/β-catenin pathway and the endocannabinoid system appear to play significant roles in anxiety and depressive symptoms. Here we examined the involvement of β-catenin in the nucleus accumbens (NAc) in extinction in rats exposed to the shock and reminders model of PTSD...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28624571/age-related-changes-of-cortical-excitability-and-connectivityin-healthy-humans-non-invasive-evaluation-of-sensorimotor-network-by-means-of-tms-eeg
#9
Florinda Ferreri, Andrea Guerra, Luca Vollero, David Ponzo, Sara Maatta, Esa Mervaala, Giulio Iannello, Vincenzo Di Lazzaro
The sensorimotor cortical system undergoes structural and functional changes across its lifespan. Some of these changes are physiological and parallel the normal aging process, while others might represent pathophysiological mechanisms underlying neurodegenerative disorders. In the last years, the study of possible age-related modifications in brain sensorimotor functional characteristics has been the focus of several research projects. Here we have used the transcranial magnetic stimulation (TMS)-EEG navigated co-registration to investigate the influence of physiological aging on the excitability and connectivity of the human sensorimotor cortical system...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28596120/myelin-induced-inhibition-in-a-spiral-ganglion-organ-culture-approaching-a-natural-environment-in-vitro
#10
Benedikt Kramer, Anke Tropitzsch, Marcus Müller, Hubert Löwenheim
The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signaling through the p75 neurotrophin receptor (p75) inhibits neurite outgrowth in the presence of myelin. Organotypic cultures derived from postnatal (P3-5) mice were used to study myelin-induced inhibition in the cochlear spiral ganglion...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627422/down-regulation-of-kv4-channel-in-drosophila-mushroom-body-neurons-contributes-to-a%C3%AE-42-induced-courtship-memory-deficits
#11
Ge Feng, Jie Pang, Xin Yi, Qian Song, Jiaxing Zhang, Can Li, Guang He, Yong Ping
Accumulation of amyloid-β (Aβ) is widely believed to be an early event in the pathogenesis of Alzheimer's disease (AD). Kv4 is an A-type K(+) channel, and our previous report shows the degradation of Kv4, induced by the Aβ42 accumulation, may be a critical contributor to the hyperexcitability of neurons in a Drosophila AD model. Here, we used well-established courtship memory assay to investigate the contribution of the Kv4 channel to short-term memory (STM) deficits in the Aβ42-expressing AD model. We found that Aβ42 over-expression in Drosophila leads to age-dependent courtship STM loss, which can be also induced by driving acute Aβ42 expression post-developmentally...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627421/hla-g%C3%A2-14bp-insertion-and-the-kir2ds1-hlac2-complex-impact-on-behavioral-impairment-in-children-with-autism-spectrum-disorders
#12
Franca R Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Alessandro Ghezzo, Salvatorica Manca, Michela Zanette, Stefano Sotgiu, Maria Martina Mensi, Milena Zanzottera, Cristina Agliardi, Andrea S Costa, Umberto Balottin, Mario Clerici
Activating KIRs-HLA-C ligands complexes and HLA-G∗14bp insertion/deletion (+/-) polymorphism were associated to Autism Spectrum Disorders (ASD) and were suggested to correlate with inflammation during fetal development. We evaluated whether HLA-G∗14bp(+/-) and KIRs-HLA-C complexes are associated with cognitive and behavioral scores and EEG profile in 119 ASD children (58 from Sardinia, 61 from Peninsular Italy). KIR2DS1-C2; KIR2DS2-C1; KIR2DL1-C2; KIR2DL2-C1; KIR2DL3-C1 and HLA-G∗14bp(+/-) were molecularly genotyped by SSP and gel electrophoresis...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627420/distinct-neural-processes-supports-post-success-and-post-error-slowing-in-the-stop-signal-task
#13
Yihe Zhang, Jaime S Ide, Sheng Zhang, Sien Hu, Nikola S Valchev, Xiaoying Tang, Chiang-Shan R Li
Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the right-hemispheric ventrolateral prefrontal cortex, in the area of inferior frontal gyrus, pars opercularis (IFGpo) and anterior insula (AI), during post-error slowing (PES). However, in similar analyses we were not able to identify regional activities during post-success slowing (PSS)...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627419/arx-polyalanine-expansion-mutations-lead-to-migration-impediment-in-the-rostral-cortex-coupled-with-a-developmental-deficit-of-calbindin-positive-cortical-gabaergic-interneurons
#14
K Lee, K Ireland, M Bleeze, C Shoubridge
The Aristaless-related homeobox gene (ARX) is indispensable for interneuron development. Patients with ARX polyalanine expansion mutations of the first two tracts (namely PA1 and PA2) suffer from intellectual disability of varying severity, with seizures a frequent comorbidity. The impact of PA1 and PA2 mutations on the brain development is unknown, hindering the search for therapeutic interventions. Here, we characterised the disturbances to cortical interneuron development in mice modelling the two most common ARX polyalanine expansion mutations in human...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627418/alterations-in-neuronal-control-of-body-weight-and-anxiety-behavior-by-glutathione-peroxidase-4-deficiency
#15
Sonja C Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G Kabra, Ulrich Hafen, Artem Romanov, Matthias H Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M Hölter, Daniela Vogt Weisenhorn, Paul T Pfluger
Elevated levels of oxidative stress and neuronal inflammation in the hypothalamus or ventral midbrain, respectively, represent common denominators for obesity and Parkinson's Disease (PD). However, little is known about defense mechanisms that protect neurons in these regions from oxidative damage. Here, we aimed to assess whether murine Gpx4, a crucial antioxidant enzyme that protects neurons from membrane damage and ferroptosis, is critical for the protection from neuronal inflammation in two distinct pathophysiologic diseases, namely metabolic dysfunction in diet-induced obesity or PD...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28606856/antinociceptive-effect-of-botulinum-toxin-a-involves-alterations-in-ampa-receptor-expression-and-glutamate-release-in-spinal-dorsal-horn-neurons
#16
Bin Hong, LingLing Yao, Linhui Ni, Li Wang, XingYue Hu
The use of botulinum toxin A (BTX-A) for various clinical therapeutic applications is increasing. It is widely believed that peripheral therapeutic or toxic effects of BTX-A are exclusively mediated by SNAP-25 cleavage. There is growing evidence of long-distance retrograde axonal transport of BTX-A on entering the central nervous system, subsequent to a local injection of the toxin. However, the prevalence of central antinociceptive effects after BTX-A peripheral application and its underlying mechanisms are unclear...
June 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28603027/plasticity-mechanisms-of-memory-consolidation-and-reconsolidation-in-the-perirhinal-cortex
#17
REVIEW
Magdalena Miranda, Pedro Bekinschtein
In this review we explore the role of the perirhinal cortex (Prh) in memory, focusing on the cellular and molecular mechanisms that have been described to happen in this structure. The Prh is part of the medial temporal lobe, but the evidences show that is has a different function than that of the hippocampus. In particular, the Prh is known to be important for object recognition memory, although it could have a role in other types of memory. However, despite the fact that object recognition tasks are widely used, information regarding the molecular and cellular mechanisms underlying this type of memory in Prh is lacking...
June 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28596119/alterations-of-m1-and-m4-acetylcholine-receptors-in-the-genetically-dystonic-dt-sz-hamster-and-moderate-antidystonic-efficacy-of-m1-and-m4-anticholinergics
#18
Melanie Hamann, Jagoda Plank, Franziska Richter, Christoph Bode, Sinisa Smiljanic, Meaghan Creed, José N Nobrega, Angelika Richter
Striatal cholinergic dysfunction has been suggested to play a critical role in the pathophysiology of dystonia. In the dt(sz) hamster, a phenotypic model of paroxysmal dystonia, M1 antagonists exerted moderate antidystonic efficacy after acute systemic administration. In the present study, we examined the effects of the M4 preferring antagonist tropicamid and whether long-term systemic or acute intrastriatal injections of the M1 preferring antagonist trihexyphenidyl are more effective in mutant hamsters. Furthermore, M1 and M4 receptors were analyzed by autoradiography and immunohistochemistry...
June 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28596116/mechanisms-of-neurofeedback-a-computation-theoretic-approach
#19
Eddy J Davelaar
Neurofeedback training is a form of brain training in which information about a neural measure is fed back to the trainee who is instructed to increase or decrease the value of that particular measure. This paper focuses on electroencephalography (EEG) neurofeedback in which the neural measures of interest are the brain oscillations. To date, the neural mechanisms that underlie successful neurofeedback training are still unexplained. Such an understanding would benefit researchers, funding agencies, clinicians, regulatory bodies, and insurance firms...
June 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28596115/differential-dendritic-remodeling-in-prelimbic-cortex-of-male-and-female-rats-during-recovery-from-chronic-stress
#20
Kelly M Moench, Cara L Wellman
Chronic stress produces differential dendritic remodeling of pyramidal neurons in medial prefrontal cortex of male and female rats. In males, this dendritic remodeling is reversible. However, the timeline of recovery, as well as the potential for reversibility in females, is unknown. Here, we examined dendritic recovery of pyramidal neurons in layer II-II of prelimbic cortex in male and female rats following chronic restraint stress (3h/day for 10days). Dendritic morphology and spine density were analyzed immediately following the cessation of stress, or following a 7- or 10-day recovery period...
June 9, 2017: Neuroscience
journal
journal
26672
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"