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European Journal of Pediatrics

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https://www.readbyqxmd.com/read/27900477/the-influence-of-seasonality-and-manufacturer-kit-lot-changes-on-17%C3%AE-hydroxyprogesterone-measurements-and-referral-rates-of-congenital-adrenal-hyperplasia-in-newborns
#1
Melissa Pearce, Erin Dauerer, A Gregory DiRienzo, Michele Caggana, Norma P Tavakoli
: Newborn screening for congenital adrenal hyperplasia (CAH) is performed by measuring the concentration of 17α-hydroxyprogesterone (17-OHP) in dried blood spots. Unfortunately, the level of 17-OHP varies due to multiple factors, and therefore, the false positive rate for the test is a challenge. We analyzed screening data from 2007 to 2015 to determine the effect of seasonal changes and manufacturer kit lot changes on 17-OHP values and on numbers of infants referred. Data from screening 2...
November 29, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27896427/predictors-of-motor-developmental-milestones-during-the-first-year-of-life
#2
Trine Flensborg-Madsen, Erik Lykke Mortensen
: Studies suggest that both pre- and postnatal factors are predictors of age of attaining milestones in infancy. However, no studies evaluate the comparative strength of these predictors and the amount of the variance in development they explain. This study aimed to conduct a systematic evaluation of a broad selection of possible predictors of age at milestone attainment and to identify factors that explain significant inter-individual variance. Mothers of 5765 children of the Copenhagen Perinatal Cohort (1959-61) recorded 12 developmental milestones prospectively during the child's first year of life...
November 28, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27888413/improving-manual-oxygen-titration-in-preterm-infants-by-training-and-guideline-implementation
#3
Henriëtte A van Zanten, Steffen C Pauws, Evelien C Beks, Ben J Stenson, Enrico Lopriore, Arjan B Te Pas
: To study oxygen saturation (SpO2) targeting before and after training and guideline implementation of manual oxygen titration, two cohorts of preterm infants <30 weeks of gestation needing respiratory support and oxygen therapy were compared. The percentage of the time spent with SpO2 within the target range (85-95%) was calculated (%SpO2-wtr). SpO2 was collected every minute when oxygen is >21%. ABCs where oxygen therapy was given were identified and analyzed. After training and guideline implementation the %SpO2-wtr increased (median interquartile range (IQR)) 48...
November 26, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27888412/diabetes-screening-in-overweight-and-obese-children-and-adolescents-choosing-the-right-test
#4
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
: Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese children aged 7 to 17 years without previously known diabetes. Using HbA1c and OGTT as diagnostic criteria, 2.4% (n = 115, 55 female) could be classified as having diabetes...
November 25, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27888411/to-screen-or-not-to-screen-for-vesicoureteral-reflux-in-children-with-ureteropelvic-junction-obstruction-a-systematic-review
#5
REVIEW
Marcus Weitz, Maria Schmidt
: Ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR) are the most common uropathies. The co-occurrence of both anomalies has led to the practice of screening for VUR in children with UPJO to prevent deterioration of kidney function due to renal scarring following urinary tract infections (UTIs). We determined the prevalence of VUR in children with UPJO for a critical assessment of VUR screening by voiding cystourethrography (VCUG). A systematic search strategy in MEDLINE, EMBASE, and CENTRAL was carried out for all articles that included VCUG, and renal scintigraphy or any other appropriate imaging technique for the diagnosis of UPJO...
November 25, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27885500/a-review-of-anaesthetic-outcomes-in-patients-with-genetically-confirmed-mitochondrial-disorders
#6
A Smith, E Dunne, M Mannion, C O'Connor, I Knerr, A A Monavari, J Hughes, N Eustace, E Crushell
: Mitochondrial disorders are a clinically and biochemically diverse group of disorders which may involve multiple organ systems. General anaesthesia (GA) poses a potential risk of decompensation in children with mitochondrial disorders, and there is little guidance for anaesthetists and other clinicians regarding the optimal anaesthetic agents and perioperative management to provide to patients with mitochondrial disease[15]. The aim of this review was to document adverse events and perioperative complications from GA in patients with genetically confirmed mitochondrial disorders...
November 24, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27866271/paediatric-biobanking-dutch-experts-reflecting-on-appropriate-legal-standards-for-practice
#7
Elcke J Kranendonk, Raoul C Hennekam, M Corrette Ploem
: Large sets of data and human specimens, such as blood, tumour tissue and DNA, are deposited in biobanks for research purposes, preferably for long periods of time and with broadly defined research aims. Our research focuses on the retention of data and biological materials obtained from children. However important such paediatric biobanks may be, the privacy interests of the children involved and the related risks may not be ignored. The privacy issues arising from paediatric biobanks are the central focus of this article...
November 19, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27864631/factors-affecting-efficacy-of-packed-red-blood-cell-transfusion-in-neonates
#8
Rakesh Kumar Pilania, Shiv Sajan Saini, Sourabh Dutta, Reena Das, Neelam Marwaha, Praveen Kumar
: The degree of increase in haematocrit and equilibration time following packed red blood cell (PRBC) transfusion in neonates is not well studied. We evaluated change in haematocrit 15 min, 6 h and 24 h after PRBC transfusion in neonates and factors predicting this change. Among neonates receiving PRBC transfusion, we recorded pre-transfusion haematocrit and a priori identified putative variables affecting change in haematocrit following transfusion. The factors affecting change in haematocrit were analyzed by multiple linear regression analysis...
November 18, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27858223/assessment-of-physical-activity-levels-fitness-and-perceived-barriers-to-physical-activity-practice-in-adolescents-cross-sectional-study
#9
Isabel Fernández, Olga Canet, Maria Giné-Garriga
: Adolescence is a time of rapid physical, psychological and social changes. Recent studies show that, at this stage, there is a decrease in physical activity (PA) levels, along with high rates of overweight and obesity. The purpose of this study was to assess PA levels and physical condition (PC) related to perceived barriers (PB) and limiting factors for PA practice in a randomised sample of adolescents in Barcelona (Spain) considering overweight status and gender. One hundred and forty-three adolescents (53...
November 17, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27853941/pulse-oximeter-saturation-target-limits-for-preterm-infants-a-survey-among-european-neonatal-intensive-care-units
#10
Maurice J Huizing, Eduardo Villamor-Martínez, Máximo Vento, Eduardo Villamor
: The optimum range of pulse oximeter oxygen saturation (SpO2) for preterm infants remains controversial. Between November 2015 and February 2016, we conducted a web-based survey aimed to investigate the current and former practices on SpO2 targets in European neonatal intensive care units (NICUs). We obtained valid responses from 193 NICUs, treating 8590 newborns ≤28 weeks per year, across 27 countries. Forty different saturation ranges were reported, ranging from 82-93 to 94-99%...
November 16, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27844149/europe-needs-to-protect-children-and-youths-against-secondhand-smoke
#11
LETTER
Adamos Hadjipanayis, Tom Stiris, Stefano Del Torso, Jean-Christophe Mercier, Arunas Valiulis, Jonas Ludvigsson
No abstract text is available yet for this article.
November 14, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27838776/acute-alcohol-intoxication-among-adolescents-the-role-of-the-context-of-drinking
#12
Bettina Grüne, Daniela Piontek, Oliver Pogarell, Armin Grübl, Cornelius Groß, Olaf Reis, Ulrich S Zimmermann, Ludwig Kraus
: This study aims (1) to describe the context of drinking among adolescents with acute alcohol intoxication (AAI) by gender, (2) to explore temporal changes in the context of drinking and (3) to analyse the association between the context of drinking and blood alcohol concentration (BAC). A retrospective chart review of 12- to 17-year-old inpatients with AAI (n = 1441) of the years 2000 to 2006 has been conducted in five participating hospitals in Germany. Gender differences in the context of drinking were tested with t test and chi(2) test...
November 12, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27837349/comparison-of-body-composition-and-nutrients-deficiencies-between-portuguese-rink-hockey-players
#13
Maria-Raquel G Silva, Hugo-Henrique Silva
: We evaluated dietary intake and body composition of child and adolescent rink-hockey players and controls. Seventy-two male rink-hockey players (38 children and 34 adolescents) and 79 male controls (43 children and 36 adolescents) were evaluated in order to collect training data, detailed dietary intake and body composition. Rink-hockey players presented significantly lower body fat (BF) and higher fat-free mass (FFM) than controls. Mean intakes of carbohydrate and protein were considered to be adequate, but mean intakes of fat were above the recommended levels in athletes...
November 12, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27826649/expanding-the-clinical-spectrum-of-chromosome-15q26-terminal-deletions-associated-with-igf-1-resistance
#14
Aisling M O'Riordan, Niamh McGrath, Farhana Sharif, Nuala P Murphy, Orla Franklin, Sally Ann Lynch, Michael J O'Grady
: Haploinsufficiency of the insulin-like growth factor-1 receptor (IGF1R) gene on chromosome 15q26.3 is associated with impaired prenatal and postnatal growth, developmental delay, dysmorphic features and skeletal abnormalities. Terminal deletions of chromosome 15q26 arising more proximally may also be associated with congenital heart disease, epilepsy, diaphragmatic hernia and renal anomalies. We report three additional cases of 15q26 terminal deletions with novel features which may further expand the spectrum of this rarely reported contiguous gene syndrome...
November 8, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27815733/acute-rheumatic-fever-outbreak-in-southern-central-european-country
#15
Urška Kočevar, Nataša Toplak, Blaž Kosmač, Luka Kopač, Samo Vesel, Natalija Krajnc, Matjaž Homan, Rina Rus, Tadej Avčin
: A decline in the incidence of acute rheumatic fever (ARF) in developed countries over the past century can be attributed to the improved public hygiene and to widespread use of antibiotics. ARF seemed to be a rare disease in southern central European country, Slovenia, up to 2010 when we noticed an increase in the number of patients with ARF. In order to assess the current incidence of ARF, we performed a retrospective study of all patients with ARF treated at the University Children's Hospital Ljubljana from January 2008 until the end of December 2014...
November 4, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27815732/the-course-of-skull-deformation-from-birth-to-5%C3%A2-years-of-age-a-prospective-cohort-study
#16
Leo A van Vlimmeren, Raoul Hh Engelbert, Maaike Pelsma, Hans Mm Groenewoud, Magda M Boere-Boonekamp, Maria Wg Nijhuis-van der Sanden
: In a continuation of a prospective longitudinal cohort study in a healthy population on the course of skull shape from birth to 24 months, at 5 years of age, 248 children participated in a follow-up assessment using plagiocephalometry (ODDI-oblique diameter difference index, CPI-cranio proportional index). Data from the original study sampled at birth, 7 weeks, 6, 12, and 24 months were used in two linear mixed models. MAIN FINDINGS: (1) if deformational plagiocephaly (ODDI <104%) and/or positional preference at 7 weeks of age are absent, normal skull shape can be predicted at 5 years of age; (2) if positional preference occurs, ODDI is the highest at 7 weeks and decreases to a stable lowest value at 2 and 5 years of age; and (3) regarding brachycephaly, all children showed the highest CPI at 6 months of age with a gradual decrease over time...
November 4, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27798729/n-terminal-pro-brain-natriuretic-peptide-can-be-an-adjunctive-diagnostic-marker-of-hyper-acute-phase-of-kawasaki-disease
#17
Hyuksool Kwon, Jin Hee Lee, Jae Yun Jung, Young Ho Kwak, Do Kyun Kim, Jin Hee Jung, Ikwan Chang, Kyuseok Kim
: The purpose of this study was to determine whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level could be a useful marker for Kawasaki disease in the pediatric emergency department (PED) and in the presence of fever duration of 4 days or less (hyper-acute phase of Kawasaki disease). Medical records of patients who were 1 month to 15 years old of age and presented at the PED with suspected Kawasaki disease from January 1, 2010, to December 31, 2014, were collected retrospectively...
October 31, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27796510/utility-and-applicability-of-the-childhood-obesity-risk-evaluation-core-index-in-predicting-obesity-in-childhood-and-adolescence-in-greece-from-early-life-the-national-action-plan-for-public-health
#18
Yannis Manios, Elpis Vlachopapadopoulou, George Moschonis, Feneli Karachaliou, Theodora Psaltopoulou, Dimitra Koutsouki, Gregory Bogdanis, Vilelmine Carayanni, Angelos Hatzakis, Stefanos Michalacos
: Early identification of infants being at high risk to become obese at their later childhood or adolescence can be of vital importance in any obesity prevention initiative. The aim of the present study was to examine the utility and applicability of the "Childhood Obesity Risk Evaluation (CORE)" index as a screening tool for the early prediction of obesity in childhood and adolescence. Anthropometric, socio-demographic data were collected cross-sectionally and retrospectively from a representative sample of 5946 children, and adolescents and were combined for calculating the CORE-index score...
October 29, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27785562/utility-of-near-infrared-light-devices-for-pediatric-peripheral-intravenous-cannulation-a-systematic-review-and-meta-analysis
#19
Joon Min Park, Min Joung Kim, Hyeon Woo Yim, Won-Chul Lee, Hyunsuk Jeong, Na Jin Kim
: We investigated the utility of near-infrared (NIR) light devices for peripheral intravenous cannulation (PIVC) in pediatric patients. We searched three databases, MEDLINE, EMBASE, and the Cochrane CENTRAL. Randomized controlled trials that compared PIVC using NIR light devices and the "traditional" method (with no assistive device) were included. The primary outcome was a failure rate at the first attempt, and the effect size was measured by the risk ratio for failure. Subgroup analysis was performed according to control group risk for failure at first attempt as an indicator of difficult procedure (low vs...
October 26, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27785561/validation-of-the-phillips-et-al-geneactiv-accelerometer-wrist-cut-points-in-children-aged-5-8%C3%A2-years-old
#20
Michael J Duncan, Susie Wilson, Jason Tallis, Emma Eyre
: This study examined the accuracy of the Phillips et al. GENEActiv accelerometer wrist worn cut-points in children aged 5-8. Fifteen children (six girls, nine boys) aged 5-8 years wore a GENEActiv monitor on their non-dominant wrist while undertaking 5 min bouts of lying supine, playing Lego, walking at slow, medium and fast pace and running. Receiver operating curve (ROC) analysis was employed to establish how well the Phillips et al. (2013) cut-points classified intensity of the activities compared to the actual intensity determined by indirect calorimetry...
October 26, 2016: European Journal of Pediatrics
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