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European Journal of Pediatrics

Niels Hilhorst, Ifigenia Spanoudi-Kitrimi, Nathalie Goemans, Marie-Anne Morren
A retrospective study in which we reviewed the hospital files of a subset of 7 patients with Duchenne muscular dystrophy participating in the open-label phase I/II PRO051-02 study in Leuven. The objective of this study was to describe in detail the injection site reactions in these children treated with drisapersen (PRO-051), a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide, that induces exon 51 skipping in Duchenne muscular dystrophy. Antisense oligonucleotides, restoring the reading frame by skipping of exons, have become a potential treatment of Duchenne muscular dystrophy and other monogenetic diseases...
November 17, 2018: European Journal of Pediatrics
Justin Jacobse, Wouter Ten Voorde, Robert Rissmann, Jacobus Burggraaf, Rebecca Ten Cate, Lenneke Schrier
In clinical practice, the burden of repeated injections in children with rheumatic disease receiving disease-modifying anti-rheumatic drugs is significant. To investigate the nature and extent of impact on the quality of life after repeated injections, we conducted a literature review. Two relevant papers were identified, both about children with juvenile idiopathic arthritis (JIA) being administered methotrexate. The results suggest that the combination of needle fear, impact of methotrexate treatment, and procedural consequences, e...
November 17, 2018: European Journal of Pediatrics
Hao-Ran Fang, Guo-Qiang Zhang, Jing-Yi Cheng, Zhong-Yue Li
Therapy-related side effects and severe antimicrobial resistance still remain an obstacle to Helicobacter pylori eradication. This meta-analysis aimed to investigate the efficacy of Lactobacillus-supplemented triple therapy on H. pylori eradication rates and therapy-related side effects in children. Five studies involving 484 pediatric patients were included in our analysis. The pooled relative risk (RR) for eradication rates in the Lactobacillus group versus the control group was 1.19 [95% confidence interval (CI) 1...
November 16, 2018: European Journal of Pediatrics
Andrea Lo Vecchio, Maria Donata Cambriglia, Maria Cristina Fedele, Francesca Wanda Basile, Fabrizia Chiatto, Michele Miraglia Del Giudice, Alfredo Guarino
Measles outbreaks were recently reported in Europe due to low immunization rates. In this scenario, identifying the reasons of no vaccination is crucial to set up strategies to improve immunization rate. A cross-sectional study was conducted to investigate the determinants of missed vaccination in children living in Southern Italy, during the 2016 outbreak. A standardized face-to-face questionnaire was used to record demographic data, immunization status, and reasons for missed vaccination. A total of 1141 children (median age 86 months, male 47...
November 14, 2018: European Journal of Pediatrics
Max Knaapen, Johanna H van der Lee, Hugo A Heij, Ernst L W van Heurn, Roel Bakx, Ramon R Gorter
Non-operative treatment of uncomplicated appendicitis in children is gaining ground. Pending definitive evidence regarding its effectiveness, there is a call to evaluate clinical recovery after non-operative treatment. In this study, we analyzed data collected during initial admission of a multicenter prospective cohort in which children, 7-17 year, were treated non-operatively for uncomplicated appendicitis. During admission clinical parameters (pain and gastro-intestinal symptoms), inflammation parameters and sequential abdominal ultrasound were recorded...
November 12, 2018: European Journal of Pediatrics
Juan-Carlos López-Gutiérrez
Propranolol has changed the management of infantile hemangiomas (IHs). We summarize the evolution of surgical treatment for IH at La Paz Children's Hospital (Madrid) in the era of propranolol, with a focus on hepatic IHs.Retrospectively, we compared surgical treatment of IHs in children referred during the periods 2004-2009 and 2009-2014. Hepatic IH mortality rates before and after the introduction of propranolol therapy were evaluated specifically.The majority of hemangiomas needing surgical excision were located on the head/face/scalp of female patients...
November 12, 2018: European Journal of Pediatrics
S J Vredebregt, H A Moll, F J Smit, J J Verhoeven
Pediatric Early Warning Scores were developed to monitor clinical deterioration of children admitted to the hospital. Pediatric Early Warning Scores could also be useful in the Emergency Department to quickly identify critically ill patients so treatment can be started without delay. To determine if a newly designed, fast, and easy to use Modified Pediatric Early Warning Score can identify critically ill children in the Emergency Department. We conducted a retrospective observational study in the Emergency Department of an urban district hospital in Rotterdam, the Netherlands...
November 9, 2018: European Journal of Pediatrics
Ahmet Osman Kılıç, Eyup Sari, Husniye Yucel, Melahat Melek Oğuz, Emine Polat, Esma Altinel Acoglu, Saliha Senel
The present study was conducted to determine young children's (aged 1-60 months) exposure to and use of mobile devices. The study included 422 parents of children aged 1-60 months admitted to pediatric outpatient clinics. A questionnaire was administered to the parents via face-to-face interview. Children's overall exposure to mobile devices was 75.6% (n = 319). Of the children, 24.4% (n = 103) had never used a mobile device. Among the children that had used a mobile device, 20.6% (n = 66) were aged between 1 and 12 months; 24...
November 6, 2018: European Journal of Pediatrics
Klara Meierer, Alexandre Hudon, Marc Sznajder, Marie-France Leduc, Danielle Taddeo, Olivier Jamoulle, Jean-Yves Frappier, Chantal Stheneur
The purpose of our study is to establish if the proportion of patients diagnosed with anorexia nervosa that have a history of excess weight has increased over a 10-year period and to study how different premorbid weight groups vary in terms of clinical characteristics. We performed a single-center, retrospective cohort study of all new patients presenting with anorexia nervosa, restrictive and binge/purge subtypes, in 2004 and 2014 at the Adolescent Medicine Clinic of Sainte-Justine University Health Centre (n = 172)...
November 5, 2018: European Journal of Pediatrics
Anne M Padding, Niels W Rutjes, Simone Hashimoto, Amit Vos, Mira S Staphorst, Wim M C van Aalderen, Marc P van der Schee
Research in children should strike the right balance between protecting underage study subjects and advancing the medical field. This study gives insight into the emotional burden that common invasive research procedures in asthma research have on young children, both from the child and parent perspective. Puppetry was used to stimulate children (age 5-6 years) to explain their emotional burden prior to and after the research procedures. We operationalised emotional burden as willingness to participate in future research and reluctance towards participation...
November 3, 2018: European Journal of Pediatrics
Titus Keller, Friederike Körber, André Oberthuer, Leonie Schafmeyer, Katrin Mehler, Kathrin Kuhr, Angela Kribs
For nasal application of neurotrophins and mesenchymal stem cells, successful delivery to the brain and therapeutic effects are known from experimental data in animals. Human breast milk contains neurotrophins and stem cells, but gavage tube feeding in preterm infants bypasses the naso-oropharynx. This is a first exploration on additional nasal breast milk and neuromorphological outcome after severe neonatal brain injury. We present a retrospective summary of 31 very low birth weight preterm infants with intraventricular hemorrhage °3/4 from one third-level neonatal center...
November 1, 2018: European Journal of Pediatrics
Mark C Kendall
No abstract text is available yet for this article.
October 31, 2018: European Journal of Pediatrics
Nisa Eda Cullas Ilarslan, Fatih Gunay, Zehra Sule Haskologlu, Sevgi Kostel Bal, Zahide Ciler Tezcaner, Ceyda Tuna Kirsaclioglu, Selma Firat, Cansu Altuntas, Bulent Ciftci, Ozan Bagis Ozgursoy, Nazan Cobanoglu
Chronic cough in children may be due to a diverse range of etiologies. We aimed to evaluate children with chronic cough following a standardized cough algorithm and assess obstructive sleep apnea (OSA) as a possible etiology. In addition, cough resolution rates of two different treatment protocols in children with non-specific cough were compared. A total of 237 children referred for chronic cough were assessed and classified according to etiologies. Children with non-specific cough were assigned either in the early-arm (group-1, n = 13) or delayed arm (group-2, n = 23)...
October 31, 2018: European Journal of Pediatrics
Takahiro Kawahara, Junichiro Tezuka, Takahito Ninomiya, Satoshi Honjo, Natsuko Masumoto, Makiko Nanishi, Hideki Nakayama, Shouichi Ohga
Cow's milk is one of the most common food allergens among children. Oral food challenge tests determine the threshold dose of allergens, but have not been standardized. To reduce the severe reactions, we developed a practical model of the test. We studied 111 high-risk patients who underwent a first milk oral food challenge on the risk-stratified dose between 2011 and 2017 for predicting the severe reaction risk. Severe reactions were defined as showing > 3 of Sampson's classification grade. Twenty-eight patients (25%) showed severe reactions without death...
October 30, 2018: European Journal of Pediatrics
Elinor Charles, Katie A Hunt, Gerrard F Rafferty, Janet L Peacock, Anne Greenough
Our aim was to compare the work of breathing (WOB) during synchronised nasal intermittent positive pressure ventilation (SNIPPV) and heated humidified high flow nasal cannula (HHHFNC) when used as post-extubation support in preterm infants. A randomised crossover study was undertaken of nine infants with a median gestational age of 27 (range 24-31) weeks and post-natal age of 7 (range 2-50) days. Infants were randomised to either SNIPPV or HHHFNC immediately following extubation. They were studied for 2 h on one mode and then switched to the other modality and studied for a further 2-h period...
October 30, 2018: European Journal of Pediatrics
Nahla Zaghloul, Laura Watkins, Jennie Choi-Rosen, Shahana Perveen, Dalibor Kurepa
The primary objective was to study agreement between X-rays and point of care ultrasound (POC-US) in determining central venous line (CVL) tip position. The secondary objective was to examine malposition rates over time using POC-US. Fifty-six neonates were enrolled who had a CVL placed. Initial X-rays and POC-US were obtained. POC-US was performed daily thereafter for the total of 6 days. US video clips were acquired in four standard echocardiographic views: subcostal, four-chamber, and short- and long-axis parasternal views...
October 29, 2018: European Journal of Pediatrics
Carla Carnovale, Faizan Mahzar, Sara Scibelli, Marta Gentili, Elena Arzenton, Ugo Moretti, Olivia Leoni, Marco Pozzi, Gabriëlla G A M Peeters, Emilio Clementi, Massimo Medaglia, Sonia Radice
Recent epidemiological studies have reported an increase in central nervous system (CNS)-active drug abuse rates in paediatric settings, raising several public health concerns. No study to date has explored this issue worldwide. We performed an extensive analysis of drugs abuse/overdose reported for children in the last decade by using the largest pharmacovigilance database, i.e. the VigiBase, collecting adverse drug reaction reports that involved at least one suspect drug belonging to the Anatomical Therapeutic Chemical code "Nervous System" through the Standardised Medical Dictionary for Drug Regulatory Affairs Queries for Drug abuse...
October 29, 2018: European Journal of Pediatrics
Noboru Matsumoto, Takeshi Hatachi, Yu Inata, Yoshiyuki Shimizu, Muneyuki Takeuchi
We performed a retrospective, observational study of patients who had spent > 14 days in the paediatric intensive care unit (PICU) of our hospital from 2011 to 2013. Specifically, long-term mortality, functional outcome, and PICU resource occupancy were examined. All prolonged-stay patients in our study were < 15 years of age. Favourable outcomes were defined as a Pediatric Overall Performance Category (POPC) score of 1-2, and unfavourable outcomes as a POPC score of 3-6 or death. During the study period, there were 1082 PICU admissions involving 805 patients, 111 (13...
October 27, 2018: European Journal of Pediatrics
Alberto Medina, Pablo Del Villar-Guerra, Vicent Modesto I Alapont
No abstract text is available yet for this article.
October 27, 2018: European Journal of Pediatrics
M C Jong, I Boers, H A van Wietmarschen, E Tromp, J O Busari, R Wennekes, I Snoeck, J Bekhof, A M Vlieger
Many children suffer from headaches. Since stress may trigger headaches, effective techniques to cope with stress are needed. We investigated the effectiveness of two mind-body techniques, transcendental meditation (TM) or hypnotherapy (HT), and compared them with progressive muscle relaxation (PMR) exercises (active control group). Children (9-18 years) suffering from primary headaches more than two times per month received either TM (N = 42), HT (N = 45) or PMR (N = 44) for 3 months. Primary outcomes were frequency of headaches and ≥ 50% reduction in headaches at 3 and 9 months...
October 24, 2018: European Journal of Pediatrics
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