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European Journal of Pediatrics

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https://www.readbyqxmd.com/read/29327140/children-s-experiences-of-congenital-heart-disease-a-systematic-review-of-qualitative-studies
#1
REVIEW
Lauren S H Chong, Dominic A Fitzgerald, Jonathan C Craig, Karine E Manera, Camilla S Hanson, David Celermajer, Julian Ayer, Nadine A Kasparian, Allison Tong
We aimed to describe the experiences of children and adolescents with congenital heart disease (CHD). Electronic databases were searched until August 2016. Qualitative studies of children's perspectives on CHD were included. Data was extracted using thematic synthesis. From 44 studies from 12 countries involving 995 children, we identified 6 themes: disrupting normality (denying the diagnosis, oscillating between sickness and health, destabilizing the family dynamic), powerlessness in deteriorating health (preoccupation with impending mortality, vulnerability to catastrophic complications, exhaustion from medical testing), enduring medical ordeals (traumatized by invasive procedures, disappointed by treatment failure, displaced by transition, valuing empathy and continuity in care, overcoming uncertainty with information), warring with the body (losing stamina, distressing inability to participate in sport, distorted body image, testing the limits), hampering potential and goals (feeling disabled, unfair judgment and exclusion, difficulties with academic achievement, limiting attainment and maintenance of life milestones), and establishing one's own pace (demarcating disease from life, determination to survive, taking limitations in their stride, embracing the positives, finding personal enrichment, relying on social or spiritual support)...
January 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29327139/galectin-3-levels-relate-in-children-to-total-body-fat-abdominal-fat-body-fat-distribution-and-cardiac-size
#2
Magnus Dencker, Daniel Arvidsson, Magnus K Karlsson, Per Wollmer, Lars B Andersen, Ola Thorsson
Galectin-3 has recently been proposed as a novel biomarker for cardiovascular disease in adults. The purpose of this investigation was to assess relationships between galectin-3 levels and total body fat, abdominal fat, body fat distribution, aerobic fitness, blood pressure, left ventricular mass, left atrial size, and increase in body fat over a 2-year period in a population-based sample of children. Our study included 170 children aged 8-11 years. Total fat mass and abdominal fat were measured by dual-energy x-ray absorptiometry (DXA)...
January 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29322352/supraclavicular-catheterization-of-the-brachiocephalic-vein-a-way-to-prevent-or-reduce-catheter-maintenance-related-complications-in-children
#3
Flora Habas, Julien Baleine, Christophe Milési, Clémentine Combes, Marie-Noëlle Didelot, Sara Romano-Bertrand, Delphine Grau, Sylvie Parer, Catherine Baud, Gilles Cambonie
Placement of a central venous catheter (CVC) in the brachiocephalic vein (BCV) via the ultrasound (US)-guided supraclavicular approach was recently described in children. We aimed to determine the CVC maintenance-related complications at this site compared to the others (i.e., the femoral, the subclavian, and the jugular). We performed a retrospective data collection of prospectively registered data on CVC in young children hospitalized in a pediatric intensive care unit (PICU) during a 4-year period (May 2011 to May 2015)...
January 10, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29318372/severe-obstructive-sleep-disorders-in-prader-willi-syndrome-patients-in-southern-italy
#4
Angelo Canora, Adriana Franzese, Enza Mozzillo, Valentina Fattorusso, Marialuisa Bocchino, Alessandro Sanduzzi
Sleep-related disordered breathing (SDB) is very common in paediatric patients affected by Prader-Willi Syndrome (PWS). However, data addressing SBD patterns and their management are lacking. The aim of the present study was to analyse SDB features in 14 PWS patients (age range, 8 months-17 years). Polygraphic registration (PG) during a 12-h nocturnal sleep was performed in all patients. Obstructive and central apnoea indices and oxygen saturation (SpO2) were recorded along with demographic and clinical data...
January 9, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29288280/is-eculizumab-efficacious-in-shigatoxin-associated-hemolytic-uremic-syndrome-a-narrative-review-of-current-evidence
#5
REVIEW
Werner Keenswijk, Ann Raes, Johan Vande Walle
Severe complications due to Shigatoxin-associated hemolytic uremic syndrome (STEC-HUS) currently present a serious challenge since no specific treatment for this condition is available. Eculizumab, a terminal complement inhibitor, has been used especially in STEC-HUS patients with severe neurological involvement, but the efficacy remains undetermined. In order to determine its efficacy, we searched the databases Pubmed, Web of Science, Embase, and LiLACS for reports describing outcomes of eculizumab administration in STEC-HUS...
December 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29285648/bacteria-from-bronchoalveolar-lavage-fluid-from-children-with-suspected-chronic-lower-respiratory-tract-infection-results-from-a-multi-center-cross-sectional-study-in-spain
#6
Amparo Escribano Montaner, Juan García de Lomas, José Ramón Villa Asensi, Oscar Asensio de la Cruz, Olga de la Serna Blázquez, Mikel Santiago Burruchaga, Pedro Mondéjar López, Alba Torrent Vernetta, Yang Feng, Melissa K Van Dyke, Janet Reyes, Pilar Garcia-Corbeira, Carla A Talarico
This cross-sectional study assessed the prevalence of bacteria isolated from Spanish children with suspected chronic lower respiratory tract infection (LRTI) for whom bronchoalveolar lavage (BAL) was indicated. BAL fluid (BALF) was collected from 191 children (aged ≥ 6 months to < 6 years, with persistent or recurrent respiratory symptoms, non-responders to usual treatment) and cultured. Nasopharyngeal swabs (NPSs) were also obtained and cultured to assess concordance of BALF and NPS findings in the same patient...
December 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29282554/soccer-helps-build-strong-bones-during-growth-a-systematic-review-and-meta-analysis
#7
REVIEW
Gabriel Lozano-Berges, Ángel Matute-Llorente, Alejandro González-Agüero, Alejandro Gómez-Bruton, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José A Casajús
The aim of this study was to analyze the effects of soccer practice on bone in male and female children and adolescents. MEDLINE, PubMed, SPORTDiscus and Web of Science databases were searched for scientific articles published up to and including October 2016. Twenty-seven studies were included in this systematic review (13 in the meta-analysis). The meta-analysis was performed by using OpenMeta[Analyst] software. It is well documented that soccer practice during childhood provides positive effects on bone mineral content (BMC) and density (BMD) compared to sedentary behaviors and other sports, such as tennis, weightlifting, or swimming...
December 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273944/health-status-of-polish-children-and-adolescents-after-cancer-treatment
#8
Krawczuk-Rybak Maryna, Panasiuk Anna, Stachowicz-Stencel Teresa, Zubowska Małgorzata, Skalska-Sadowska Jolanta, Sęga-Pondel Dorota, Czajńska-Deptuła Aneta, Sławińska Dorota, Badowska Wanda, Kamieńska Elżbieta, Pobudejska-Pieniążek Aneta, Wieczorek Maria
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273943/thyroid-disease-in-children-and-adolescents-with-pten-hamartoma-tumor-syndrome-phts
#9
Michaela Plamper, Felix Schreiner, Bettina Gohlke, Janina Kionke, Eckard Korsch, James Kirkpatrick, Mark Born, Stefan Aretz, Joachim Woelfle
Patients with PTEN hamartoma tumor syndrome (PHTS) are at increased risk of developing benign and malignant tumors, including thyroid carcinoma. Benign thyroid lesions and single cases of thyroid carcinoma have been reported in children with PHTS. We conducted a retrospective, single-centered study including children and adolescents with a molecularly proven diagnosis of PTEN. Our cohort consists of 16 patients, with a mean age at diagnosis PHTS of 5.7 years. Twelve of 16 cases exhibited thyroid abnormalities (75%)...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273942/repeated-early-life-exposure-to-inter-parental-conflict-increases-risk-of-preadolescent-mental-health-problems
#10
Elizabeth M Westrupp, Stephanie Brown, Hannah Woolhouse, Deirdre Gartland, Jan M Nicholson
This study investigated the association between inter-parental conflict at a single occasion, or repeated over early childhood, and children's internalizing and externalizing problems at 10-11 years; and examined potential mechanisms via social risk, maternal mental health, and parenting. Data were five time points from the Baby cohort of the Longitudinal Study of Australian Children (N = 3696, recruited in 2004). Verbal or physical inter-parental conflict was measured at 0-1, 2-3, 4-5, and 6-7 years. Internalizing and externalizing problems (Strengths and Difficulties Questionnaire) were measured via mother-, father-, teacher-, and child-report at 10-11 years...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273941/associations-between-metabolic-syndrome-components-and-markers-of-inflammation-in-welsh-school-children
#11
Non Eleri Thomas, David A Rowe, Elaine M Murtagh, Jeffrey W Stephens, Rhys Williams
We investigated the multivariate dimensionality and strength of the relationship between metabolic syndrome (MetS) and inflammation in children. Caucasian school children (N = 229; 12-14 years) from Wales were tested on several health indicators including measures of body composition, inflammation, fasting glucose regulation, blood pressure, and lipids. The multivariate association between MetS and inflammation was investigated via canonical correlation analysis. Data were corrected for non-normality by log transformation, and sex-specific z-scores computed for variables where there was a significant sex difference...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29273940/investigation-of-clostridium-difficile-ribotypes-in-symptomatic-patients-of-a-german-pediatric-oncology-center
#12
Arne Simon, Markus Mock, Norbert Graf, Lutz von Müller
In a German pediatric oncology unit, the attending physicians diagnosed 27 cases of Clostridium difficile-associated disease (CDI) from January 01, 2010 to October 31, 2013. This refers to a CDI incidence density of 2.0/1000 inpatient days. According to the hospital hygiene standard, symptomatic patients with CDI were kept in contact isolation. Most patients (median age 8.2 years) suffered from acute lymphoblastic leukemia; 88.9% were treated with broad-spectrum antibiotics during the preceding 4 weeks. 29...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29270826/paediatric-departments-need-to-improve-residents-training-in-adolescent-medicine-and-health-a-position-paper-of-the-european-academy-of-paediatrics
#13
Pierre-André Michaud, Lenneke Schrier, Robert Ross-Russel, Laila van der Heijden, Lien Dossche, Sian Copley, Tommaso Alterio, Artur Mazur, Lukasz Dembinski, Adamos Hadjipanayis, Stefano Del Torso, Helena Fonseca, Anne-Emmanuelle Ambresin
In many European countries, paediatric junior staff has no formal training in adolescent medicine and is ill-equipped to deal with issues and health problems such as substance use, unprotected sex, eating disorders and transition to adult care. This position paper of the European Academy of Paediatrics proposes a set of competency-based training goals and objectives as well as pedagogic approaches that are expected to improve the capacity of paediatricians to meet the needs of this important segment of the paediatric population...
December 21, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29270825/provided-information-and-parents-comprehension-at-the-time-of-admission-of-their-child-in-pediatric-intensive-care-unit
#14
Agathe Béranger, Charlotte Pierron, Laure de Saint Blanquat, Naïm Bouazza, Sandrine Jean, Hélène Chappuy
This study evaluated the first interaction (FI) between parents and health care providers at the time of admission of a child in pediatric intensive care unit (PICU), and explored the extent to which parents understood the medical information. This prospective study took place in three French university-affiliated PICUs. Forty-two parents of 30 children were interviewed. The physician and nurse who took care of the child completed a questionnaire. We evaluated parents' comprehension (excellent, fair, or poor) by comparing parents' and physicians' responses to six items: diagnosis, affected organ, reason for hospitalization, prognosis, treatments, and further investigations...
December 21, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29260376/desmopressin-use-in-pediatric-nocturnal-enuresis-patients-is-there-a-sex-difference-in-prescription-patterns
#15
Marie Krarup Schroeder, K V Juul, B Mahler, J P Nørgaard, S Rittig
Desmopressin is a long-established treatment for nocturnal enuresis with clear guidelines regarding its usage. A sex difference in renal sensitivity has recently been reported in adults. The objective of this study was to investigate real-life desmopressin prescription in the Danish pediatric population, and prescription patterns which may reflect a sex difference in pediatric usage. Formulation, dose, treatment duration, and safety (hyponatremia) were investigated. 40,596 children received 214,220 desmopressin prescriptions between 2004 and 2011 in the Danish National Prescription Registry...
December 19, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29260375/changing-characteristics-of-hospital-admissions-but-not-the-children-admitted-a-whole-population-study-between-2000-and-2013
#16
Maryam Al-Mahtot, Rebecca Barwise-Munro, Philip Wilson, Steve Turner
There are increasing numbers of emergency medical paediatric admissions. Our hypothesis was that characteristics of children and details of their emergency admissions are also changing over time. Details of emergency admissions in Scotland 2000-2013 were analysed. There were 574,403 emergency admissions, median age 2.3 years. The age distribution, proportion of boys and socioeconomic status of children admitted were essentially unchanged. Emergency admissions rose by 49% from 36/1000 children per annum to 54/1000 between 2000 and 2013...
December 19, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29255951/impact-of-war-on-child-health-in-northern-syria-the-experience-of-m%C3%A3-decins-sans-fronti%C3%A3-res
#17
Lana Meiqari, Maartje Hoetjes, Louisa Baxter, Annick Lenglet
Few data are available to evaluate the impact of Syrian war on civilian population; to describe this impact on child health, this article uses data from Médecins Sans Frontières-Operational Centre Amsterdam's activities in Tal-Abyad and Kobane cities, northern Syria (2013-2016). Data were obtained from routine medical datasets and narrative reports, for out-patient clinics, immunisation, nutritional monitoring and assessments, and in-patient care, and were analysed quantitatively and qualitatively. Infections were the largest contributor to morbidity...
December 19, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29255950/clinical-and-genetic-characterisation-of-a-series-of-patients-with-triple-a-syndrome
#18
Erdal Kurnaz, Paolo Duminuco, Zehra Aycan, Şenay Savaş-Erdeve, Nursel Muratoğlu Şahin, Melişah Keskin, Elvan Bayramoğlu, Marco Bonomi, Semra Çetinkaya
Triple A syndrome (TAS) or Allgrove syndrome (OMIM #231550) is a rare autosomal recessive disorder characterised by adrenocorticotropic hormone-resistant adrenal insufficiency, alacrima, achalasia, and neurological and dermatological abnormalities. Mutations in the AAAS gene on chromosome 12q13 encoding the nuclear pore protein ALADIN have been reported in these patients. Between 2006 and 2017, we evaluated six patients with a clinical diagnosis of TAS, based on the presence of at least two symptoms, usually adrenal insufficiency and alacrima...
December 19, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29255949/measured-parental-height-in-turner-syndrome-a-valuable-but-underused-diagnostic-tool
#19
Yasmine Ouarezki, Filiz Mine Cizmecioglu, Chourouk Mansour, Jeremy Huw Jones, Emma Jane Gault, Avril Mason, Malcolm D C Donaldson
Early diagnosis of Turner syndrome (TS) is necessary to facilitate appropriate management, including growth promotion. Not all girls with TS have overt short stature, and comparison with parental height (Ht) is needed for appropriate evaluation. We examined both the prevalence and diagnostic sensitivity of measured parental Ht in a dedicated TS clinic between 1989 and 2013. Lower end of parental target range (LTR) was calculated as mid-parental Ht (correction factor 12.5 cm minus 8.5 cm) and converted to standard deviation scores (SDS) using UK 1990 data, then compared with patient Ht SDS at first accurate measurement aged > 1 year...
December 18, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29255948/thromboelastometry-for-diagnosis-of-neonatal-sepsis-associated-coagulopathy-an-observational-study
#20
Rozeta Sokou, George Giallouros, Aikaterini Konstantinidi, Katerina Pantavou, Georgios Nikolopoulos, Stefanos Bonovas, Theodore Lytras, Elias Kyriakou, Ioannis Lambadaridis, Antonis Gounaris, Panagiota Douramani, Serena Valsami, Violetta Kapsimali, Nicoletta Iacovidou, Argirios E Tsantes
Our aim was to evaluate the potential role of standard extrinsically activated thromboelastometry (EXTEM) assay in the early detection of neonatal sepsis. We studied 91 hospitalized neonates categorized in two groups: group A included 35 neonates with confirmed sepsis, while group B included 56 neonates with suspected sepsis; 274 healthy neonates served as controls. Whenever sepsis was suspected, EXTEM assay was performed, Score for Neonatal Acute Physiology Perinatal Extension (SNAPPE) and Tοllner score were calculated, and clinical findings and laboratory results were recorded...
December 18, 2017: European Journal of Pediatrics
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