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European Journal of Pediatrics

Elisabeth Rauch, Florian B Lagler, Harald Herkner, Walter Gall, Robert Sauermann, Silvia Hetz, Christoph Male
Aims of this survey were to evaluate prescription patterns for children and adolescents in primary and hospital care settings in Austria and to identify the medicines used most frequently in this population. Prescription data were assessed for the year 2014: for primary care, reimbursement data were obtained from Austrian health insurances; for hospital care, information on medicines dispensed to pediatric wards from hospital pharmacies. Frequencies of medicine use were analyzed by Anatomical Therapeutic Chemical classification system, age groups, and care setting...
July 5, 2018: European Journal of Pediatrics
Cézane Priscila Reuter, Miria Suzana Burgos, Cláudia Daniela Barbian, Jane Dagmar Pollo Renner, Silvia Isabel Rech Franke, Elza Daniel de Mello
The metabolic syndrome (MetS), although more frequent in adults, is already evident in the infant-juvenile population. On the other hand, there are different criteria for the diagnosis, without a consensus of which is the best to be used in this population. The aim of this study was to evaluate the agreement between different criteria for diagnosis of MetS in adolescents from southern Brazil. A cross-sectional study consisting of a sample of 1200 subjects, 679 females, aged between 12 and 17 years. MetS was assessed by three different criteria: Cook (2003), Ferranti (2004), and International Diabetes Federation - IDF (2007)...
July 4, 2018: European Journal of Pediatrics
Margaretha M S Wessels, Nicky de Rooij, Lian Roovers, Jan Verhage, Willemien de Vries, M Luisa Mearin
Celiac disease (CD) is known to be more prevalent in first-degree relatives of patients. In this retrospective cohort study of 609 relatives between 1994 and 2016, we investigated the effect of sex, HLA type, and age at time of index celiac diagnosis. Pearson's chi-square test and Kaplan-Meier survival analysis were used as statistical analyses. CD screening was carried out for 427 relatives (70%), resulting in a prevalence of 15%. HLA typing in 335 relatives showed HLA-DQ2/DQ8 positivity in 87.5%. In 63% of children and all parents, celiac disease was diagnosed at first screening...
July 4, 2018: European Journal of Pediatrics
Matthew A Thimm, Daniel Rhee, Clifford M Takemoto, Wikrom Karnsakul, Carmen Cuffari, Anthony L Guerrerio, Alejandro Garcia, John Gearhart, Thierry A G M Huisman, Misun Hwang
Contrast-enhanced ultrasound (CEUS) is a versatile imaging modality that improves the diagnostic potential of conventional ultrasound. It allows for portable imaging at the bedside. In this paper, we illustrate how CEUS can be used in evaluating several focal lesions in the pediatric population, including liver hemangioma, telangiectasias, splenic hamartomas, and bladder lesions. We describe the ultrasound findings and contrast enhancement patterns associated with these lesions. Findings are correlated with MRI, CT, and/or pathology when available...
July 3, 2018: European Journal of Pediatrics
Susanne Marie Fisch, Martina Patrizia Neininger, Freerk Prenzel, Matthias Karl Bernhard, Frauke Hornemann, Andreas Merkenschlager, Wieland Kiess, Thilo Bertsche, Astrid Bertsche
Epilepsy and bronchial asthma are frequent in adolescents. Data on adolescents' experiences with their disease and on their expectations for the future, however, is scarce. Patients of a university hospital aged 12 to 17 with epilepsy or bronchial asthma were interviewed based on a questionnaire. Forty-five patients with epilepsy and 47 with bronchial asthma were interviewed. Adolescents with epilepsy felt more impaired by their disease (median 2.5; Q25/Q75 0.75/3.0; 6-level Likert scales: 0 = not at all, 5 = very strong) than those with asthma (1...
July 3, 2018: European Journal of Pediatrics
Takehito Otani, Yoshihiko Morikawa, Itaru Hayakawa, Yukari Atsumi, Kouki Tomari, Yutaro Tomobe, Kazuhiro Uda, Yu Funakoshi, Chiho Sakaguchi, Shizuka Nishimoto, Hiroshi Hataya
The usefulness of ultrasound guidance in peripheral intravenous access placement has yet to be established in children. In this prospective comparative study, we investigated success rates of intravenous access placement with ultrasound guidance in a pediatric emergency department. After a failed first attempt with the conventional technique, the second and third attempts were conducted using either the ultrasound guidance (a real-time, dual operator method) or the conventional technique. The success rates within the two interventional attempts were then compared...
June 30, 2018: European Journal of Pediatrics
Adamos Hadjipanayis, Francis P Crawley, Tom Stiris, David Neubauer, Pierre-André Michaud
Child trafficking is among the most lucrative criminal activities in the world and growing rapidly. Poverty, natural disasters, armed conflicts and, in particular, migration put vulnerable children at high risk of trafficking. Accurate statistics on child trafficking are not available due to its illegal nature. Moreover, trafficking may not be consistently recorded and reported by European countries, mainly because of different perceptions as to who is considered a victim of trafficking. Around 4000-5000 children were identified as presumed victims of trafficking in European Union countries from 2013 to 2014; this is an underestimate of the problem because many victims go unrecognised...
June 26, 2018: European Journal of Pediatrics
Carin W Verlaat, Cynthia van der Starre, Jan A Hazelzet, Dick Tibboel, Johannes van der Hoeven, Joris Lemson, Marieke Zegers
We studied the occurrence of adverse events (AEs) in low-risk non-survivors (LNs), compared to low-risk survivors (LSs), high-risk non-survivors (HNs), and high-risk survivors (HSs) in two pediatric intensive care units (PICUs). The study was performed as a retrospective patient record review study, using a PICU-trigger tool. A random sample of 48 PICU patients (0-18 years) was chosen, stratified into four subgroups of 12 patients: LNs, LSs, HNs, and HSs. Primary outcome was the occurrence of AEs. The severity, preventability, and nature of the indentified AEs were determined...
June 26, 2018: European Journal of Pediatrics
Thekla F Vrolijk-Bosschaart, Sonja N Brilleslijper-Kater, Marc A Benninga, Ramón J L Lindauer, Arianne H Teeuw
Recognizing child sexual abuse (CSA) in children is difficult, as there can be many hurdles in the assessment of alleged CSA. With this paper, we try to improve the recognition of CSA by discussing: (1) the difficulties regarding this matter and (2) the diagnostic evaluation of alleged CSA, combining both practical clinical recommendations based on recent research. Children are restrained to disclose CSA due to various reasons, such as fears, shame, and linguistic or verbal limitations. Associations between CSA and urogenital or gastrointestinal symptoms, internalizing and externalizing behavioral problems, post-traumatic stress symptoms, and atypical sexual behavior in children have been reported...
June 25, 2018: European Journal of Pediatrics
Marie-Ange Bozzini, Gregorio P Milani, Mario G Bianchetti, Emilio F Fossali, Sebastiano A G Lava
Approximately 500 cases of idiopathic systemic capillary leak syndrome (Clarkson syndrome) have been reported worldwide. This life-threatening condition is characterized by episodes of increase in vascular permeability with loss of fluid into the interstitium and presents with acute onset of edema, signs of tissue hypoperfusion, hemoconcentration, and low blood protein level. It has been diagnosed mainly in middle-aged adults with a monoclonal gammopathy. We performed a systematic review of the literature on Clarkson syndrome in subjects ≤ 18 years of age...
June 23, 2018: European Journal of Pediatrics
Kishore Baske, Shiv Sajan Saini, Sourabh Dutta, Venkataseshan Sundaram
We compared epinephrine and dopamine as a first-line vasoactive drug in 40 neonates (enrolled in two gestational age strata ≤ 306/7 and ≥ 310/7  weeks) with fluid-refractory septic shock. Epinephrine or dopamine was initiated at 0.2 or 10 μg/kg/min, respectively. If shock persisted after 15 min, epinephrine or dopamine was increased to 0.3 or 15 μg/kg/min, respectively (16-30 min), and thereafter to 0.4 or 20 μg/kg/min (31-45 min). Proportion of neonates achieving 'reversal of shock' (defined as systolic and diastolic BP > fifth centile and capillary filling time < 3 s and left ventricular output ≥ 150 mL/kg/min) by 45 min [5 (25%) vs 6 (30%), RR 0...
June 23, 2018: European Journal of Pediatrics
Inke Marie Albertsen, Barbara Brockmann, Karsten Hollander, Jan Schröder, Astrid Zech, Susanne Sehner, Ralf Stücker, Kornelia Babin
The aim of this pilot study was to investigate whether the clinical Matthiass test can be objectified by means of dynamic rasterstereography in children. We aimed at discriminating between postural weak and strong children. Dynamic rasterstereography was used to capture sagittal spinal posture changes during the modified Matthiass test (mMT). Primary outcomes were spinal posture changes (trunk inclination, kyphotic and lordotic angles) during the test. Two-step cluster analysis was run jointly on the three primary outcomes...
June 23, 2018: European Journal of Pediatrics
Marketa Vrbova, Petra Dorociakova, Roman Vyskovsky, Lubica Palkovicova Murinova, Peter Ciznar, Katarina Rausova, Scott J N McNabb, Eva Reichrtova, Eva Budinska, Vojtech Thon
Allergic diseases have increased in developed countries during the past decades. A cohort of Slovak children was followed from birth to track allergic symptoms dynamics in early childhood. Information on allergic symptoms (atopic dermatitis = AD, rhino conjunctivitis = RC, wheezing = Wh, urticaria = Ur) and food allergies among children was based on clinical evaluation of children by allergists at three developmental stages (infant, toddler, preschool). Out of 320 cases of allergies, 64 infants, 145 toddlers, and 195 preschool children suffered from AD, RC, Wh, Ur, or their combinations (i...
June 22, 2018: European Journal of Pediatrics
Line Pickering, Poul Jennum, Rikke Ibsen, Jakob Kjellberg
We estimated the long-term socioeconomic consequences and health care costs of Neisseria meningitidis meningitis (NM). The prospective cohort study included Danish individuals with onset of NM in childhood and adolescence, diagnosed between 1980 and 2009. Health care costs and socioeconomic data were obtained from nationwide administrative and health registers. Two thousand nine hundred two patients were compared with 11,610 controls matched for age, gender, and other sociodemographic characteristics. In the follow-up analysis at the age of 30 years, 1028 patients were compared with 4452 controls...
June 20, 2018: European Journal of Pediatrics
Aaron Drovandi, Kelvin Robertson, Matthew Tucker, Niechole Robinson, Stephen Perks, Therése Kairuz
Clinical pharmacists provide beneficial services to adult patients, though their benefits for paediatric hospital patients are less defined. Five databases were searched using the MeSH terms 'clinical pharmacist', 'paediatric/paediatric', 'hospital', and 'intervention' for studies with paediatric patients conducted in hospital settings, and described pharmacist-initiated interventions, published between January 2000 and October 2017. The search strategy after full-text review identified 12 articles matching the eligibility criteria...
June 19, 2018: European Journal of Pediatrics
Ayse Betul Ergul, Emrah Calıskan, Hasan Samsa, Ikbal Gokcek, Ali Kaya, Gozde Erturk Zararsiz, Yasemin Altuner Torun
The effectiveness of using a face mask with a small diffuser for oxygen delivery (OxyMask) was compared to use of a high-flow nasal cannula (HFNC) in patients with moderate or severe bronchiolitis.The study population in this open, phase 4, randomized controlled trial consisted of 60 patients aged 1-24 months diagnosed with moderate or severe bronchiolitis and admitted to an intensive care unit (ICU) for oxygen therapy. The patients were randomized into two groups according to the method of oxygen delivery: a diffuser mask group and an HFNC group...
June 18, 2018: European Journal of Pediatrics
Amparo Escribano Montaner, Juan García de Lomas, José Ramón Villa Asensi, Oscar Asensio de la Cruz, Olga de la Serna Blázquez, Mikel Santiago Burruchaga, Pedro Mondéjar López, Alba Torrent Vernetta, Yang Feng, Melissa K Van Dyke, Janet Reyes, Pilar Garcia-Corbeira, Carla A Talarico
No abstract text is available yet for this article.
June 14, 2018: European Journal of Pediatrics
Dorothée C van Trier, Ineke van der Burgt, Renske W Draaijer, Johannes R M Cruysberg, Cees Noordam, Jos M Draaisma
The aim of this retrospective study is to describe ocular findings in a large Noonan syndrome cohort and to detect associations between ocular features and genetic mutations that were not found in earlier studies. We collected ophthalmological and genetic data of 105 patients (median age, 12 years; range, 0-60 years) clinically diagnosed as Noonan syndrome. The ocular findings were linked to the genotypes. All patients with Noonan syndrome showed multiple abnormalities in the categories of vision and refraction, external ocular features, ocular alignment and motility, anterior ocular segment, and posterior ocular segment...
June 9, 2018: European Journal of Pediatrics
Xuan Li, Ye Chen, Yunjia Tang, Yueyue Ding, Qiuqin Xu, Lin Sun, Weiguo Qian, Guanghui Qian, Liqiang Qin, Haitao Lv
The purpose of this study was to identify the clinical features and laboratory factors that are predictive of intravenous immunoglobulin (IVIG)-resistant Kawasaki disease. Multiple databases were searched for relevant studies on IVIG-resistant Kawasaki disease published from January 2002 to April 2017. Eligible studies were retrieved by manual review of the references. Stata 12 was used for the meta-analysis. Weighted mean differences and odds ratios with 95% confidence intervals were calculated for several indices...
June 8, 2018: European Journal of Pediatrics
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