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Lutz Hamann, Juan S Ruiz-Moreno, Malgorzata Szwed, Malgorzata Mossakowska, Linn Lundvall, Ralf R Schumann, Bastian Opitz, Monika Puzianowska-Kuznicka
BACKGROUND: Aging is a multifactorial process driven by several conditions. Among them, inflamm-aging is characterized by chronic low-grade inflammation driving aging-related diseases. The aged immune system is characterized by the senescence-associated secretory phenotype, resulting in the release of proinflammatory cytokines contributing to inflamm-aging. Another possible mechanism resulting in inflamm-aging could be the increased release of danger- associated molecular patterns (DAMPs) by increased cell death in the elderly, leading to a chronic low-grade inflammatory response...
October 26, 2018: Gerontology
József Tollár, Ferenc Nagy, Tibor Hortobágyi
OBJECTIVES: To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms. DESIGN: Randomized clinical trial. SETTING: Outpatient physiotherapy clinic in a hospital. PARTICIPANTS: Seventy-four stage 2-3, nondemented PD patients were included in this study. INTERVENTION: The groups were as follows: EXE (n = 25), CYC (n = 25), and a wait-listed control group (CON; n = 24)...
October 26, 2018: Gerontology
He Zhou, Javad Razjouyan, Debopriyo Halder, Anand D Naik, Mark E Kunik, Bijan Najafi
BACKGROUND: The physical frailty assessment tools that are currently available are often time consuming to use with limited feasibility. OBJECTIVE: To address these limitations, an instrumented trail-making task (iTMT) platform was developed using wearable technology to automate quantification of frailty phenotypes without the need of a frailty walking test. METHODS: Sixty-one older adults (age = 72.8 ± 9.9 years, body mass index [BMI] = 27...
October 25, 2018: Gerontology
Tibor Hortobágyi, Azusa Uematsu, Lianne Sanders, Reinhold Kliegl, József Tollár, Renato Moraes, Urs Granacher
BACKGROUND: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. OBJECTIVES: Using beam walking distance as a measure of dynamic balance, the BEAM consortium will determine the psychometric properties, lifespan and patient reference values, the relationship with selected "dynamic balance tests," and the accuracy of beam walking distance to predict falls...
October 18, 2018: Gerontology
Frederico Pieruccini-Faria, Yanina Sarquis-Adamson, Manuel Montero-Odasso
BACKGROUND: Older adults with Mild Cognitive Impairment (MCI) are at higher risk of falls and injuries, but the underlying mechanism is poorly understood. Inappropriate anticipatory postural adjustments to overcome balance perturbations are affected by cognitive decline. However, it is unknown whether anticipatory gait control to avoid an obstacle is affected in MCI. OBJECTIVE: Using the dual-task paradigm, we aim to assess whether gait control is affected during obstacle negotiation challenges in older adults with MCI...
October 12, 2018: Gerontology
Lee Friedman, Susan Avila, Daniel Friedman, Wendy Meltzer
BACKGROUND: Studies have demonstrated that measures of lower quality of care and associated adverse health effects are more prevalent in for-profit nursing homes compared to not-for-profit facilities. However, these studies omit persons who receive care in the community setting, and exclusively focus on isolated clinical signs that may obscure the true effect size, since these clinical signs rarely occur in isolation. OBJECTIVE: In this study, we use the Clinical Signs of Neglect Scale (CSNS), which is an aggregate measure of clinical signs of neglect and substandard care, to evaluate the association of residence type on health outcomes among individuals living in both private community residences and for-profit and not-for-profit long-term care facilities...
October 9, 2018: Gerontology
Georg Wick
No abstract text is available yet for this article.
October 2, 2018: Gerontology
Ai Koyanagi, Hans Oh, Davy Vancampfort, Andre F Carvalho, Nicola Veronese, Brendon Stubbs, Elvira Lara
BACKGROUND: Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. OBJECTIVE: We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa) using nationally representative data. METHODS: Cross-sectional, community-based data on individuals aged ≥50 years from the World Health Organization's Study on Global Ageing and Adult Health were analyzed...
September 10, 2018: Gerontology
Marina Peball, Philipp Mahlknecht, Mario Werkmann, Kathrin Marini, Franziska Murr, Helga Herzmann, Heike Stockner, Roberto de Marzi, Beatrice Heim, Atbin Djamshidian, Peter Willeit, Johann Willeit, Stefan Kiechl, Dora Valent, Florian Krismer, Gregor Karl Wenning, Michael Nocker, Katherina Mair, Werner Poewe, Klaus Seppi
BACKGROUND: Sarcopenia and frailty are found in up to one-third of the general elderly population. Both are associated with major adverse health outcomes such as nursing home placement, disability, decreased quality of life, and death. Data on the frequency of both syndromes in Parkinson's disease (PD), however, are very limited. OBJECTIVE: We aimed to screen for sarcopenia and frailty in PD patients and to assess potential associations of both geriatric syndromes with demographic and clinical parameters as well as quality of life...
September 10, 2018: Gerontology
Joseph M Castellano
Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting health-care costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzhei-mer's disease. As the proportion of aged individuals continues to rise in the coming decades, aging-related costs are expected to increase dramatically. Diverse approaches have emerged to meet the clinical need to treat aging and its associated conditions, including those aimed at increasing longevity, slowing the aging process itself, and improving healthspan...
September 7, 2018: Gerontology
Stefan Kiechl, Johann Willeit
The Bruneck Study is a prospective community-based study enrolling an age- and sex-stratified random sample of 1,000 men and women. It achieved an extraordinary participation rate of 93.4% and a near-complete long-term follow-up exceeding a quarter of a century (1990-2018). High-quality ascertainment of most common human diseases enables reliable evaluation of: disease epidemiology, overlaps between age-related diseases, and risk factors, and discovery of novel biomarkers. Research priorities include atherosclerosis, cardiovascular disease, aging and longevity, neurological diseases, disorders of the bone, and cancer...
September 4, 2018: Gerontology
Bojana Jakic, Mattias Carlsson, Maja Buszko, Giuseppe Cappellano, Christian Ploner, Elisabeth Onestingel, Maria Foti, Hubert Hackl, Egon Demetz, Hermann Dietrich, Cecilia Wick, Georg Wick
BACKGROUND: Atherosclerosis is the leading cause of death worldwide. The disease development is by and large driven by old age and lifestyle factors, such as diet, physical activity, and smoking. In the present study, we have investigated the effect of exercise and diet on the development of atherosclerosis in young and aged mice. OBJECTIVE: This study aimed at comparing multiple age-dependent factors that may influence atherosclerosis in a transgenic mouse model...
August 30, 2018: Gerontology
Caren J Frost, Nathaniel J Morgan, Hayder Allkhenfr, Susan Dearden, Rebekah Ess, Wafi Fawzan Albalawi, Allyson Berri, L Scott Benson, Lisa H Gren
In 2017, there were over 65 million displaced persons at the global level, with approximately 23 million of these people living as refugees around the world. In this same year, the US resettled 53,716 refugees, with the State of Utah receiving 954 of those refugees. Refugees, in general, often face health-related challenges upon resettlement. Since the health of aging refugee men and women is of growing concern, host communities face significant challenges in accommodating the health needs of a diverse refugee population...
August 21, 2018: Gerontology
Nele Christin Lemke, Christian Werner, Stefanie Wiloth, Peter Oster, Jürgen M Bauer, Klaus Hauer
BACKGROUND: Specific dual-task (DT) training is effective to improve DT performance in trained tasks in patients with dementia (PwD). However, it remains an open research question whether successfully trained DTs show a transfer effect to untrained DT performances. OBJECTIVE: To examine transfer effects and the sustainability of a specific DT training in PwD. METHODS: One hundred and five patients with mild-to-moderate dementia (Mini-Mental State Examination: 21...
July 24, 2018: Gerontology
Gizem Hülür, Henrike Wolf, Florian Riese, Nathan Theill
BACKGROUND: Research on terminal decline has widely documented that cognitive performance steeply declines with nearing death. To date, it is unclear whether these changes are normative, based on pathologies associated with (preclinical) dementia, or both. OBJECTIVES: We analyzed heterogeneity in trajectories of terminal cognitive change in Swiss nursing home residents with the objective of examining whether terminal change is normative or whether one or multiple subgroup(s) with relative stability exist...
July 24, 2018: Gerontology
Tammy T Hshieh, Tamara G Fong, Eva M Schmitt, Edward R Marcantonio, Madeline L D'Aquila, Jacqueline Gallagher, Guoquan Xu, Yun R Guo, Tatiana F Abrantes, Sylvie E Bertrand, Richard N Jones, Sharon K Inouye
BACKGROUND/OBJECTIVES: To describe the design, procedures, and cohort for the Better ASsessment of ILlness -(BASIL) study, which is conducted to develop and test new delirium severity measures, compare them with existing measures, and examine related clinical outcomes. METHODS: Prospective cohort study with 1 year follow-up of study participants at a large teaching hospital in Boston, Massachusetts. After brief cognitive testing and the Delirium Symptom Interview, delirium and delirium severity were rated daily in the hospital using the Confusion Assessment Method (CAM) and CAM-Severity score, the Delirium Rating Scale-Revised-98 (DRS-R-98), and the Memorial Delirium Assessment Scale (MDAS)...
July 20, 2018: Gerontology
Giuseppe Barbesino
BACKGROUND: Thyroid hormones have significant effects on the cardiovascular systems. In general, hyperthyroidism is associated with an increased risk of dysrhythmias, while hypothyroidism may cause atherosclerosis. Recent large studies have sought to identify aging-associated changes in thyroid function and their relevance to cardiovascular morbidity and mortality in the elderly. Conflicting results have often been published, likely due to the heterogeneity of the studied populations...
July 20, 2018: Gerontology
Helene Benveniste, Xiaodan Liu, Sunil Koundal, Simon Sanggaard, Hedok Lee, Joanna Wardlaw
The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic products. Specifically, the glymphatic network serves as a "front end" for waste clearance, and is connected downstream to an authentic lymphatic network, associated with dura covering the brain as well as cranial nerves and large vessels at the skull exits. The anatomical and functional interconnections between these two networks are not completely understood...
July 11, 2018: Gerontology
Ana A Esteban-Burgos, Jamal El Mansouri-Yachou, Rafael Muñoz-Ramirez, Cesar Hueso-Montoro, Maria P Garcia-Caro, Rafael Montoya-Juarez
BACKGROUND: Health status and the needs presented by people admitted to nursing homes make it necessary to contemplate aspects such as prognosis to offer quality palliative care. OBJECTIVE: To compare the prognostic utility in nursing homes of two prognostic models of 6-month survival based on the Palliative Prognostic Index (PPI) or Palliative Performance Status (PPS) instruments and palliative needs indicators. METHODS: A longitudinal prospective observational and analytical cohort study of survival and prognostic models in 88 patients with palliative needs (assessed by the NECPAL-ICO-CCOMS©) from an Andalusian (Spain) nursing home was performed...
June 29, 2018: Gerontology
Nina Kohn, Maria Brown, Israel Doron
BACKGROUND: Academics have long called for greater interaction between gerontologists and legal scholars. However, prior studies have suggested that disciplinary borders remain a barrier to such interaction, hampering gerontology's ability to function as a truly multi- or interdisciplinary field. OBJECTIVE: This study was designed to understand the nature of current interactions between legal scholars and gerontologists, and to identify opportunities to advance scientific dialogue and cooperation between the two...
June 19, 2018: Gerontology
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