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Neuroscience Letters

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https://www.readbyqxmd.com/read/29031782/editorial
#1
EDITORIAL
Ernesto Carafoli, Marisa Brini, Tito Calì
No abstract text is available yet for this article.
October 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29031781/the-effectiveness-of-istradefylline-for-the-treatment-of-gait-deficits-and-sleepiness-in-patients-with-parkinson-s-disease
#2
Keita Matsuura, Hiroyuki Kajikawa, Ken-Ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
PURPOSE: Istradefylline is useful in treating the wearing-off state in Parkinson's disease (PD). We investigated the effectiveness of istradefylline (ISD) in improving arousal, sleep, and gait deficits in patients with PD. METHODS: We examined 14 patients with PD treated with ISD. We assessed the patients using the Unified Parkinson's Disease Rating Scale, Parkinson's Disease Questionnaire, Timed Up-and-Go test (TUG), Freezing of Gait Questionnaire (FOG-Q), Epworth Sleepiness Scale (ESS), and Parkinson's Disease Sleep Scale (PDSS) before and 1 month after ISD use...
October 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29031780/towards-plasma-like-collisionless-trajectories-in-the-brain
#3
Arturo Tozzi, James F Peters, Eva Déli
Plasma studies depictcollisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel, empirically testable, brain model which takes into account collisionless movements of charged particles in a system, the brain, equipped with oscillations. The model is cast in a mathematical fashionwith the potential of being operationalized, because it can be assessed in terms of McKean-Vlasov equations, derived from the classical Vlasov equations for plasma...
October 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29030221/inhibition-of-bdnf-production-by-mpp-through-up-regulation-of-mir-210-3p-contributes-to-dopaminergic-neuron-damage-in-mptp-model
#4
Shan Zhang, Shu Chen, Anmin Liu, Jungang Wan, Lingwen Tang, Niandong Zheng, Yi Xiong
The neurotrophin brain-derived neurotrophic factor (BDNF) has been involved in supporting of neuron survival. The observation of reduced level of BDNF in the substantia nigra (SN) of Parkinson's disease (PD) patients suggests its important role in neuron protection in PD pathogenesis. However, the mechanism underlying the down-regulation of BDNF in PD was largely unknown. In this study, we found that miR-210-3p is involved in the regulation of BDNF production by 1-methyl-4-phenylpyridinium (MPP(+)). MPP(+) inhibits the BDNF production in SH-SY5Y cells through a transcription independent manner...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29030220/the-correlation-between-dna-methylation-and-transcriptional-expression-of-human-dopamine-transporter-in-cell-lines
#5
Desheng Zhai, Songji Li, Gaopan Dong, Dushuang Zhou, Yuxin Yang, Xin Wang, Ying Zhao, Yunlei Yang, Zhicheng Lin
This study aims to investigate the relationship between DNA methylation and expression of human dopamine transporter (hDAT). We examined methylation status of hDAT in cells with various hDAT expression levels, including two dopaminergic neural cell lines (SK-N-AS and SH-SY-5Y) and one non-dopaminergic cell line (HEK293) by bisulfite sequencing PCR(BSP). The effects of DNA methyltransferase inhibitor 5-aza-dC or/and histone deacetylase inhibitor (HDACi, sodium butyrate, NaB) on the DNA methylation status and mRNA expression levels of hDAT were examined...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29030219/local-infusion-of-ghrelin-into-the-lateral-amygdala-blocks-extinction-of-conditioned-taste-aversion-in-rats
#6
Ge Song, Qianqian Zhu, Fubing Han, Shuai Liu, Chenyang Zhao, Yu Zhou
Ghrelin is an orexigenic brain-gut hormone promoting feeding and regulating energy metabolism in human and rodents. Our previous study showed that ghrelin locally infused into the lateral amygdala (LA) activates its receptor GHS-R1a and blocks acquisition of conditioned taste aversion (CTA) in rats. In this study, we further investigated the effect of ghrelin/GHS-R1a signaling on extinction of CTA. We found that local infusion of ghrelin (5μM, 0.5μl/side) into the LA not only interfered with CTA memory formation, but also the extinction of CTA memory...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29030218/acupuncture-suppresses-intravenous-methamphetamine-self-administration-through-gaba-receptor-s-mediation
#7
Yi Jeong Choi, Nam Jun Kim, Rong Jie Zhao, Da Hye Kim, Chae Ha Yang, Hee Young Kim, Young S Gwak, Eun Young Jang, Jae Su Kim, Yun Kyu Lee, Hyun Jong Lee, Sang Nam Lee, Sung Chul Lim, Bong Hyo Lee
OBJECTIVES: Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects of psychostimulant. Based on, the present study investigated if acupuncture could suppress intravenous methamphetamine self-administration behavior. In addition, a possible neuronal mechanism was investigated. MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were trained to intake food pellet...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29024727/interspecific-comparison-of-mushroom-body-synaptic-complexes-of-dimorphic-workers-in-the-ant-genus-pheidole
#8
Darcy G Gordon, Alejandra Zelaya, Katherine Ronk, James F A Traniello
Social insects may have morphologically and behaviorally specialized workers that vary in requirements for sensory information processing, making them excellent systems to examine the relationship between brain structure and behavior. The density and size of synaptic complexes (microglomeruli, MG) in the mushroom bodies (MB) have served as proxies for processing ability and synaptic plasticity have been shown to vary among insect species that differ in behavioral complexity. To understand the relationship between behavioral specialization and synaptic structure, we examined age-related changes in MG density and size between minor worker and soldier subcastes in two species of Pheidole ants, P...
October 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29024726/the-antiepileptic-drug-levetiracetam-promotes-neuroblast-differentiation-and-expression-of-superoxide-dismutase-in-the-mouse-hippocampal-dentate-gyrus-via-pi3k-akt-signalling
#9
Bing Chun Yan, Hui Shen, Yuanyuan Zhang, Xiaolu Zhu, Jie Wang, Pei Xu, Dan Jiang, Xing Yu
Levetiracetam (LEV), a second-generation antiepileptic drug, is commonly prescribed to treat certain types of seizures. Few studies have investigated the effects of LEV on hippocampal neurogenesis and its related mechanisms. In the present study, we investigated the effects of LEV on cell proliferation and neuronal differentiation in the mouse hippocampal dentate gyrus (DG). We here demonstrate a dose-dependent increase in Ki-67-immunoreactive cells in the subgranular zone of the DG in LEV-treated mice, and doublecortin-immunoreactive cells were also significantly increased in the hippocampal DG of mice treated with LEV...
October 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28993209/rotigotine-a-dopamine-receptor-agonist-increased-bdnf-protein-levels-in-the-rat-cortex-and-hippocampus
#10
Naoki Adachi, Aya Yoshimura, Shuichi Chiba, Shintaro Ogawa, Hiroshi Kunugi
Brain-derived neurotrophic factor (BDNF) critically controls the fate and function of the neuronal network and has received much attention as a target of many brain diseases. Dopaminergic system dysfunction has also been implicated in a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor agonist, is used in the treatment of Parkinson's disease and restless legs syndrome. To investigate the effects of rotigotine on neuronal functions both in vivo and in vitro, rats and primary cortical neurons were administered rotigotine, and the mRNA and protein expression levels of BDNF, its receptor TrkB and downstream signaling molecules, and synaptic proteins were determined...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28993208/intestinal-microbiota-impact-sepsis-associated-encephalopathy-via-the-vagus-nerve
#11
Suyan Li, Jian Lv, Jianguo Li, Zhaolong Zhao, Hui Guo, Yanni Zhang, Shichao Cheng, Jianbin Sun, Hongming Pan, Shaopeng Fan, Zhongxin Li
OBJECTIVE: The pathogenesis of sepsis associated encephalopathy (SAE) remains poorly understood. Vagus nerve plays an important role in gut-microbiota-brain axis. This study aimed to investigate whether vague nerve is a key mediator of the impact of intestinal microbiota on SAE. METHODS: Male rats were randomly divided into four groups (n=20): SHAM (SH) group, lipopolysaccharide (LPS) group, fecal microbiota transplantation (FMT) +LPS group, and vagotomy (VGX)+LPS+FMT group...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28993207/effects-of-transcranial-direct-current-stimulation-on-time-limit-and-ratings-of-perceived-exertion-in-physically-active-women
#12
Eduardo Lattari, Bruno Soares de Oliveira, Bruno Ribeiro Ramalho Oliveira, Rodrigo Cunha de Mello Pedreiro, Sérgio Machado, Geraldo Albuquerque Maranhão Neto
The limiting factors of maximum performance in humans have been extensively investigated. The aim of this study was to verify the acute effects of transcranial direct current stimulation on time limit (i.e., the time by which an individual is able to sustain a certain intensity of effort) at 100% of peak power (tlim@100%PP) and ratings of perceived exertion (RPE). Eleven moderately active women underwent an anthropometric evaluation and a maximal incremental test in the cycle ergometer, in order to obtain peak power (PP)...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28988973/comparative-connectomics-mapping-the-inter-individual-variability-of-connections-within-the-regions-of-the-human-brain
#13
Csaba Kerepesi, Balázs Szalkai, Bálint Varga, Vince Grolmusz
The human braingraph, or connectome is a description of the connections of the brain: the nodes of the graph correspond to small areas of the gray matter, and two nodes are connected by an edge if a diffusion MRI-based workflow finds fibers between those brain areas. We have constructed 1015-vertex graphs from the diffusion MRI brain images of 392 human subjects and compared the individual graphs with respect to several different areas of the brain. The inter-individual variability of the graphs within different brain regions was discovered and described...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28988972/arginine-vasopressin-antagonizes-the-effects-of-prostaglandin-e2-on-the-spontaneous-activity-of-warm-sensitive-and-temperature-insensitive-neurons-in-the-medial-preoptic-area-in-rats
#14
Jian-Hui Xu, Xiao-Yu Hou, Yu Tang, Rong Luo, Jie Zhang, Chang Liu, Yong-Lu Yang
Arginine vasopressin (AVP) plays an important role in thermoregulation and antipyresis. We have demonstrated that AVP could change the spontaneous activity of thermosensitive and temperature insensitive neurons in the preoptic area. However, whether AVP influences the effects of prostaglandin E2 (PGE2) on the spontaneous activity of neurons in the medial preoptic area (MPO) remains unclear. Our experiment showed that PGE2 decreased the spontaneous activity of warm-sensitive neurons, and increased that of low-slope temperature-insensitive neurons in the MPO...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28987818/the-anti-apoptotic-effect-of-fluid-mechanics-preconditioning-by-cells-membrane-and-mitochondria-in-rats-brain-microvascular-endothelial-cells
#15
Shan Tian, Fengping Zhu, Ruiping Hu, Song Tian, Xingxing Chen, Dan Lou, Bing Cao, Qiulei Chen, Bai Li, Fang Li, Yulong Bai, Yi Wu, Yulian Zhu
Exercise preconditioning is a simple and effective way to prevent ischemia. This paper further provided the mechanism in hemodynamic aspects at the cellular level. To study the anti-apoptotic effects of fluid mechanics preconditioning, Cultured rats brain microvascular endothelial cells were given fluid intervention in a parallel plate flow chamber before oxygen glucose deprivation. It showed that fluid mechanics preconditioning could inhibit the apoptosis of endothelial cells, and this process might be mediated by the shear stress activation of Tie-2 on cells membrane surface and Bcl-2 on the mitochondria surface...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28987817/the-sodium-channel-activator-lu-ae98134-normalizes-the-altered-firing-properties-of-fast-spiking-interneurons-in-dlx5-6-mice
#16
Nadia Lybøl von Schoubye, Kristen Frederiksen, Uffe Kristiansen, Anders Victor Petersen, Nils Ole Dalby, Morten Grunnet, Henrik Sindal Jensen, Thomas Jespersen, Vikaas S Sohal, Jean-François Perrier
Mental disorders such as schizophrenia are associated with impaired firing properties of fast spiking inhibitory interneurons (FSINs) causing reduced task-evoked gamma-oscillation in prefrontal cortex. The voltage-gated sodium channel NaV1.1 is highly expressed in PV-positive interneurons, but only at low levels in principal cells. Positive modulators of Nav1.1 channels are for this reason considered potential candidates for the treatment of cognitive disorders. Here we examined the effect of the novel positive modulator of voltage-gated sodium channels Lu AE98134...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28987816/aspirin-increases-ferroportin-1-expression-by-inhibiting-hepcidin-via-the-jak-stat3-pathway-in-interleukin-6-treated-pc-12-cells
#17
Su-Na Huang, Huai-Zhen Ruan, Mesona Yung-Jin Chen, Gan Zhou, Zhong Ming Qian
To understand the potential mechanisms involved in the beneficial effects of aspirin (ASA) in mood disorders, Alzheimer's (AD) and Parkinson's disease (PD), we investigated the effects of ASA on the expression of iron transport proteins transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1), and iron storage protein ferritin light chain (Ft-L) in interleukin-6 (IL-6)-treated PC-12 cells. We demonstrated that IL-6 alone could induce a severe decline in Fpn1 expression and cell viability, and an increase in Ft-L protein, while ASA could markedly diminish the effects of IL-6 on these parameters...
October 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28986122/mitochondrial-ros-mediated-post-transcriptional-regulation-of-%C3%AE-synuclein-through-mir-7-and-mir-153
#18
Goun Je, Yoon-Seong Kim
Dysregulation of human alpha-synuclein (α-SYN) is one of the major contributors in the pathogenesis of Parkinson's disease. 1-methyl-4-phenylpyridinium (MPP(+)) is well known neurotoxin which increases α-SYN expression and causes dopaminergic neuronal death. Increasing evidence suggests microRNAs (miRNAs), especially miRNA-7 and miR-153, have important role in the regulation of α-SYN translation and they can prevent MPP(+)-mediated neuronal death. Here, we examined whether MPP(+)-mediated upregulation of α-SYN expression is directly related to miRNA-7 and miR-153...
October 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28982597/chronic-trans-astaxanthin-treatment-exerts-antihyperalgesic-effect-and-corrects-co-morbid-depressive-like-behaviors-in-mice-with-chronic-pain
#19
Xi Jiang, Qizhi Yan, Fuhe Liu, Changfeng Jing, Lianshu Ding, Lijin Zhang, Cong Pang
Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare. Trans-astaxanthin has been shown in our previous studies to exert antidepressant-like effect. This work aimed to investigate the effects of trans-astaxanthin on pain-related depressive-like behaviors in mice and explored the mechanism(s). Chronic constriction injury (CCI) model was used in this research. Chronic pain was evaluated by thermal hyperalgesia in Hargreaves test and mechanical allodynia in von Frey test, depressive-like behaviors were evaluated by immobility time in forced swim test and tail suspension test...
October 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28982596/subsequent-maternal-separation-exacerbates-neurobehavioral-abnormalities-in-rats-neonatally-exposed-to-sevoflurane-anesthesia
#20
Jiaojiao Yang, Lingsha Ju, Min Jia, Hui Zhang, Xiaoru Sun, Muhuo Ji, Jianjun Yang, Anatoly E Martynyuk
Several recent studies suggest that in the human population, a routine, short anesthetic in otherwise healthy infants is void of neurodevelopmental insult. On the other hand, many human retrospective epidemiological studies report evidence of cognitive abnormalities in children after testing those who had different anesthesia-requiring procedures in early childhood. We tested in a rat model whether post-anesthesia stressful environmental factors can contribute to developmental abnormalities that were initiated by a relatively short exposure to sevoflurane, the most widely used anesthetic in pediatric anesthesia, whose polyvalent actions include enhancement of gamma-aminobutyric acid type A receptor (GABAAR) activity...
October 2, 2017: Neuroscience Letters
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