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Journal of Neuroscience Research

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https://www.readbyqxmd.com/read/30402941/human-bdnf-rs6265-polymorphism-as-a-mediator-for-the-generalization-of-contextual-anxiety
#1
Marta Andreatta, Dorothea Neueder, Hannah Genheimer, Miriam A Schiele, Christoph Schartner, Jürgen Deckert, Katharina Domschke, Andreas Reif, Matthias J Wieser, Paul Pauli
The Met allele of the human brain-derived neurotrophic factor (BDNF) gene might be a risk factor for anxiety disorders and is associated with reduced hippocampal volume. Notably, hippocampus plays a crucial role in contextual learning and generalization. The role of the BDNF gene variation in human context-conditioning and generalization is still unknown. We investigated 33 carriers of the Met allele (18 females) and 32 homozygous carriers of the Val allele (15 females) with a virtual-reality context-conditioning paradigm...
November 7, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30394562/repeated-isoflurane-in-adult-male-mice-leads-to-acute-and-persistent-motor-decrements-with-long-term-modifications-in-corpus-callosum-microstructural-integrity
#2
Nikita M Bajwa, Jeong B Lee, Shina Halavi, Richard E Hartman, Andre Obenaus
Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental studies. Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane-induced inhalational anesthesia can lead to various pathophysiological and cognitive alterations. Therefore, we aimed to investigate the long-term behavioral and white matter consequences of repeated isoflurane exposure. Twenty 3-month-old C57BL/6J male mice received one exposure of isoflurane for 40 min or 2 exposures to isoflurane separated by 3 days...
November 5, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30387501/distribution-patterns-of-the-zebrafish-neuronal-intermediate-filaments-inaa-and-inab
#3
Meng-Lin Liao, Wei-Hau Peng, Daphne Kan, Chung-Liang Chien
It has been reported that the neuronal intermediate filament (IF) α-internexin may plays a role in the formation of the neuronal cytoskeleton during mammalian development. From a phylogenetic viewpoint, zebrafish express inaa and inab as homologs of mammalian α-internexin. However, the distribution patterns of the inaa and inab proteins throughout zebrafish development have not been well-characterized. We generated antibodies specific for zebrafish inaa and inab and analyzed the distribution of these two proteins in developing zebrafish...
November 2, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30383302/choosing-the-right-cell-for-spinal-cord-repair
#4
LETTER
Lyandysha V Zholudeva, Michael A Lane
No abstract text is available yet for this article.
November 1, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30378715/c1q-tnf-related-protein-9-a-novel-therapeutic-target-in-ischemic-stroke
#5
REVIEW
Cui Yang, Fan Fan, Darrell Sawmiller, Jun Tan, Qingsong Wang, Yang Xiang
Ischemic stroke has become a serious public health problem, which is in need of advanced research on the prevention and treatment. As a newly discovered adipokine, C1q/TNF-related protein 9 (CTRP9) plays a vital role in the pathogenesis of coronary atherosclerosis disease (CAD), including regulating energy metabolism, modulating vasomotion, protecting endothelial cells, inhibiting platelet activation, inhibiting pathological vascular remodeling, stabilizing atherosclerotic plaques, and protecting heart. The present review raised a critical question of whether CTRP9 could also have the capacity of protecting the brain tissue and decreasing the severity of brain lesions in the ischemic stroke since CAD and ischemic stroke are both the major subtypes of atherosclerotic vascular diseases which share a large of common pathogenesis in the vascular lesion particularly...
October 31, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30367726/neuronal-extracellular-micrornas-mir-124-and-mir-9-mediate-cell-cell-communication-between-neurons-and-microglia
#6
Tatyana Veremeyko, Inna S Kuznetsova, Marina Dukhinova, Amanda W Y Yung, Ekaterina Kopeikina, Natasha S Barteneva, Eugene D Ponomarev
In contrast to peripheral macrophages, microglia in the central nervous system (CNS) exhibit a specific deactivated phenotype; however, it is not clear how this phenotype is maintained. Two alternative hypotheses were postulated recently: (a) microglia differ from peripheral macrophages being derived from the yolk sac (YS), whereas peripheral macrophages originate from bone marrow (BM); (b) microglia acquire a specific phenotype under the influence of the CNS microenvironment. We have previously shown that microglia express miR-124, which was also induced in BM-derived macrophages co-cultured with a neurons...
October 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30367522/the-c-terminal-flanking-peptide-of-neuropeptide-y-npy-is-not-essential-for-seizure-suppressant-actions-of-prepro-npy-overexpression-in-male-rats
#7
Katia Soud, Søren Heide Jørgensen, David Paul Drucker Woldbye, Andreas Toft Sørensen
The full coding sequence of neuropeptide Y (NPY), prepro-NPY, is sequentially metabolized into three peptides; an N-terminus 28-amino acid signaling peptide, the NPY peptide itself (NPY1-36), and a 30-amino acid C-terminus peptide, known as the C-terminal flanking peptide of neuropeptide-Y (CPON). While the signaling peptide directs intracellular trafficking and NPY1-36 is well characterized, the biological function of CPON is unknown. This is noteworthy because CPON is co-stored and co-released along with NPY1-36 and could thus potentially serve important functions...
October 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30367513/aberrant-left-insular-cortex-response-a-possible-pathogenesis-of-reduced-vagal-nervous-system-activity-in-heart-failure-reply
#8
LETTER
Xiaopeng Song, Mary A Woo, Rajesh Kumar
No abstract text is available yet for this article.
October 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30362289/protein-dna-interaction-one-step-closer-to-understanding-the-mechanism-of-neurodegeneration
#9
Andrei Surguchov
No abstract text is available yet for this article.
October 26, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30345547/insights-into-major-facilitator-superfamily-domain-containing-protein-2a-mfsd2a-in-physiology-and-pathophysiology-what-do-we-know-so-far
#10
REVIEW
Pinar Eser Ocak, Umut Ocak, Prativa Sherchan, John H Zhang, Jiping Tang
Major facilitator superfamily domain-containing protein-2a (Mfsd2a) which was considered as an orphan transporter has recently gained attention for its regulatory role in the maintenance of proper functioning of the blood-brain barrier. Besides the major role of Mfsd2a in maintaining the barrier function, increasing evidence has emerged with regard to the contributions of Mfsd2a to various biological processes such as transport, cell fusion, cell cycle, inflammation and regeneration, managing tumor growth, functioning of other organs with barrier functions or responses to injury...
October 22, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30345544/ap-1-and-the-injury-response-of-the-gfap-gene
#11
Michael Brenner, Albee Messing, Michelle L Olsen
Increased GFAP gene expression is a common feature of CNS injury, resulting in its use as a reporter to investigate mechanisms producing gliosis. AP-1 transcription factors are among those proposed to participate in mediating the reactive response. Prior studies found a consensus AP-1 binding site in the GFAP promoter to be essential for activity of reporter constructs transfected into cultured cells, but to have little to no effect on basal transgene expression in mice. Since cultured astrocytes display some properties of reactive astrocytes, these findings suggested that AP-1 transcription factors are critical for the upregulation of GFAP in injury, but not for its resting level of expression...
October 22, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30320468/zebrafish-models-for-personalized-psychiatry-insights-from-individual-strain-and-sex-differences-and-modeling-gene-x-environment-interactions
#12
REVIEW
Andrey D Volgin, Oleg A Yakovlev, Konstantin A Demin, Murilo S de Abreu, Polina A Alekseeva, Ashton J Friend, Anton M Lakstygal, Tamara G Amstislavskaya, Wandong Bao, Cai Song, Allan V Kalueff
Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine...
October 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30320448/therapeutic-spectrum-of-interferon-%C3%AE-in-ischemic-stroke
#13
REVIEW
Madhuri Wanve, Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanta Pravalika, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R Yavagal, Kunjan R Dave, Pallab Bhattacharya
Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes...
October 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30315659/blood-brain-barrier-disruption-and-angiogenesis-in-a-rat-model-for-neurocysticercosis
#14
Rogger P Carmen-Orozco, Danitza G Dávila-Villacorta, Yudith Cauna, Edson G Bernal-Teran, Leandra Bitterfeld, Graham L Sutherland, Nancy Chile, Rensson H Céliz, María C Ferrufino-Schmidt, Cesar M Gavídia, Charles R Sterling, Héctor H García, Robert H Gilman, Manuela Renee Verástegui
Neurocysticercosis (NCC) is a helminth infection affecting the central nervous system caused by the larval stage (cysticercus) of Taenia solium. Since vascular alteration and blood-brain barrier (BBB) disruption contribute to NCC pathology, it is postulated that angiogenesis could contribute to the pathology of this disease. This study used a rat model for NCC and evaluated the expression of two angiogenic factors called vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF2). Also, two markers for BBB disruption, the endothelial barrier antigen and immunoglobulin G, were evaluated using immunohistochemical and immunofluorescence techniques...
October 13, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30311677/insights-on-unc-104-dynein-dynactin-interactions-and-their-implications-on-axonal-transport-in-caenorhabditis-elegans
#15
Chih-Wei Chen, Yu-Fei Peng, Ying-Cheng Yen, Prerana Bhan, Muniesh Muthaiyan Shanmugam, Dieter R Klopfenstein, Oliver I Wagner
Bidirectional cargo transport in neurons can be explained by two models: the "tug-of-war model" for short-range transport, in which several kinesin and dynein motors are bound to the same cargo but travel in opposing directions, and by the "motor coordination model" for long-range transport, in which small adaptors or the cargo itself activates or deactivates opposing motors. Direct interactions between the major axonal transporter kinesin-3 UNC-104(KIF1A) and the dynein/dynactin complex remains unknown...
October 12, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30311670/sex-adhd-symptoms-and-chrna5-genotype-influence-reaction-time-but-not-response-inhibition
#16
Andrea B Schote, Clara A L Sayk, Kathrin Pabst, Jacqueline K Meier, Christian Frings, Jobst Meyer
People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We examined the effects of two functional polymorphisms rs3841324 (S/L) and rs16969968 (G/A) of the cholinergic gene CHRNA5, ADHD symptoms and sex on response inhibition/reaction time in the Stop Signal Task...
October 12, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30272377/aberrant-left-insular-cortex-response-a-possible-pathogenesis-of-reduced-vagal-nervous-system-activity-in-heart-failure
#17
LETTER
Michiaki Nagai, Keigo Dote, Masaya Kato
No abstract text is available yet for this article.
October 1, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30260491/molecular-dissection-of-cone-photoreceptor-enriched-genes-encoding-transmembrane-and-secretory-proteins
#18
Samantha Papal, Christopher E Monti, Mackenzie E Tennison, Anand Swaroop
Cone photoreceptors mediate color perception and daylight vision through intricate synaptic circuitry. In most mammalian retina, cones are greatly outnumbered by rods and exhibit inter-dependence for functional maintenance and survival. Currently, we have limited understanding of cone-specific molecular components that mediate response to extrinsic signaling factors or are involved in communication with rods and other retinal cells. To fulfill this gap, we compared the recently-published transcriptomes of developing S-cone-like photoreceptors from the Nrl-/- mouse retina with those of rods and identified candidate genes responsible for cone cell functions and communication...
September 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30259550/neuroinflammation-and-blood-brain-barrier-disruption-following-traumatic-brain-injury-pathophysiology-and-potential-therapeutic-targets
#19
REVIEW
Suraj Sulhan, Kristopher A Lyon, Lee A Shapiro, Jason H Huang
Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million persons in the United States live with a TBI-related disability, including several neurocognitive disorders and functional limitations. Following the primary mechanical injury in TBI, literature suggests the presence of a delayed secondary injury involving a variety of neuroinflammatory changes...
September 27, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30242872/crotalus-atrox-disintegrin-reduces-hemorrhagic-transformation-by-attenuating-matrix-metalloproteinase-9-activity-after-middle-cerebral-artery-occlusion-in-hyperglycemic-male-rats
#20
Devin W McBride, Eric C K Gren, Wayne Kelln, William K Hayes, John H Zhang
Hemorrhagic transformation after ischemic stroke is an independent predictor for poor outcome and is characterized by blood vessel rupture leading to brain edema. To date, no therapies for preventing hemorrhagic transformation exist. Disintegrins from the venom of Crotalus atrox have targets within the coagulation cascade, including receptors on platelets. We hypothesized that disintegrins from C. atrox venom can attenuate hemorrhagic transformation by preventing activation of matrix metalloproteinase after middle cerebral artery occlusion (MCAO) in hyperglycemic rats...
September 22, 2018: Journal of Neuroscience Research
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