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Inflammation

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https://www.readbyqxmd.com/read/28332176/a-naphthoquinone-from-sinningia-canescens-inhibits-inflammation-and-fever-in-mice
#1
Luís A Lomba, Paulo H Vogt, Victor E P Souza, Mariane C G Leite-Avalca, Maria H Verdan, Maria Elida A Stefanello, Aleksander R Zampronio
We previously showed that plants from the genus Sinningia are a source of antiinflammatory and analgesic compounds with different mechanisms of action. The present study evaluated the antiinflammatory, antinociceptive, and antipyretic effects of a crude extract (CE) from Sinningia canescens, its fractions, and 6-methoxy-7-hydroxy-α-dunnione (MHD) in mice. These effects were evaluated using carrageenan (Cg)-induced paw edema, acetic acid- and formalin-induced nociception, mechanical hyperalgesia, lipopolysaccharide (LPS)-induced fever, and plasma cytokine levels...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28326455/neutralization-of-mmp-2-and-tnfr1-regulates-the-severity-of-s-aureus-induced-septic-arthritis-by-differential-alteration-of-local-and-systemic-proinflammatory-cytokines-in-mice
#2
Sahin Sultana, Rana Adhikary, Biswadev Bishayi
Despite advancement in the field of antibiotics septic arthritis remains a serious concern till date. Staphylococcus aureus is the most common bacterium that causes septic arthritis. Severity of this disease is directly correlated with chronic inflammation induced by proinflammatory cytokines like TNF-α, interleukin (IL)-1β, IL-6, and induction of matrix metalloproteinases (MMPs) including MMP-2. The objective of our study was to evaluate the role of MMP-2 and tumor necrosis factor receptor 1 (TNFR1) in the pathogenesis of S...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28326454/quercetin-and-ascorbic-acid-suppress-fructose-induced-nlrp3-inflammasome-activation-by-blocking-intracellular-shuttling-of-txnip-in-human-macrophage-cell-lines
#3
Jung-Yoon Choe, Seong-Kyu Kim
The aim of this study was to identify the role of thioredoxin-interacting protein (TXNIP) and its interaction with antioxidants in the activation of the fructose-induced NOD-like receptor protein 3 (NLRP3) inflammasome in human macrophages. The study was performed with U937 and THP-1 macrophage cell lines. Total reactive oxygen species (ROS) were measured by flow cytometry. Interleukin-1β (IL-1β), IL-18, NLRP3, TXNIP, and caspase-1 protein expression was detected using western blotting. Quantitative real-time polymerase chain reaction was used to detect IL-1β, IL-18, and caspase-1 gene expression...
March 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28321785/microrna-34a-suppresses-autophagy-in-alveolar-type-ii-epithelial-cells-in-acute-lung-injury-by-inhibiting-foxo3-expression
#4
Lan Song, Fangliang Zhou, Lijuan Cheng, Mei Hu, Yingchun He, Bo Zhang, Duanfang Liao, Zhaojun Xu
Excessive autophagic activity of alveolar type II epithelial (AT-II) cells is one of the main causes of acute lung injury (ALI); however, the underlying molecular mechanism remains to be determined. The microRNAs (miRNAs) are involved with autophagy in many diseases. The objective of this study was therefore to investigate the relationship between the miRNA expression and the autophagic activity of the AT-II cells in the pathogenesis of ALI and its molecular mechanism. A mouse model of ALI and AT-II cell injury was induced using lipopolysaccharide (LPS) in vivo and in vitro, and the expression of miR-34a and the autophagy-related proteins LC3 II/I and p62 were determined...
March 21, 2017: Inflammation
https://www.readbyqxmd.com/read/28315999/artesunate-protects-lps-induced-acute-lung-injury-by-inhibiting-tlr4-expression-and-inducing-nrf2-activation
#5
Deli Zhao, Jinling Zhang, Guangquan Xu, Qiushi Wang
Artesunate, a derivative of artemisinin, has been reported to have anti-inflammatory property. However, few studies showed the protective effects of artesunate on lung injury. In this study, we aimed to investigate the effects of artesunate on LPS-induced lung injury in mice. The mice were treated with artesunate 1 h before or after LPS treatment. The effects of artesunate on lung MPO activity and malondialdehyde (MDA) content were detected. The lung wet/dry radio and the numbers of inflammatory cells in BALF were also measured...
March 18, 2017: Inflammation
https://www.readbyqxmd.com/read/28303417/protective-effect-of-amygdalin-on-lps-induced-acute-lung-injury-by-inhibiting-nf-%C3%AE%C2%BAb-and-nlrp3-signaling-pathways
#6
Ao Zhang, Weiyun Pan, Juan Lv, Hui Wu
The acute lung injury (ALI) is a leading cause of morbidity and mortality in critically ill patients. Amygdalin is derived from the bitter apricot kernel, an efficacious Chinese herbal medicine. Although amygdalin is used by many cancer patients as an antitumor agent, there is no report about the effect of amygdalin on acute lung injury. Here we explored the protective effect of amygdalin on ALI using lipopolysaccharide (LPS)-induced murine model by detecting the lung wet/dry ratio, the myeloperoxidase (MPO) in lung tissues, inflammatory cells in the bronchoalveolar lavage fluid (BALF), inflammatory cytokines production, as well as NLRP3 and NF-κB signaling pathways...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28303416/microrna-24-modulates-staphylococcus-aureus-induced-macrophage-polarization-by-suppressing-chi3l1
#7
Zhang Jingjing, Zhang Nan, Wu Wei, Guo Qinghe, Wang Weijuan, Wang Peng, Wang Xiangpeng
Macrophages play a crucial role in host innate anti-Staphylococcus aureus defense, which is tightly regulated by multiple factors, including microRNAs. A recent study showed that miR-24 plays an important role in macrophage polarization. Here, we investigated the biological function of miR-24 in S. aureus-stimulated macrophages. The results revealed that miR-24 expression was significantly decreased in both human and mouse macrophage cell lines with S. aureus stimulation in a time-dependent manner. Moreover, miR-24 overexpression significantly decreased the production of M1 phenotype markers, such as IL-6, iNOS, TNF-α, CD86, and CD80, whereas it increased the production of M2 markers, such as Arg1, CCL17, CCL22, CD163, and CD206, in S...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28303415/anti-inflammatory-effects-of-schisandrin-b-on-lps-stimulated-bv2-microglia-via-activating-ppar-%C3%AE
#8
Na Liu, Jin-Xu Zheng, Yuan-Su Zhuang, Zhi-Kui Zhou, Jin-Hua Zhao, Lei Yang
Schisandrin B (Sch B), a dibenzocyclooctadiene lignan isolated from Schisandra chinensis (Turcz.) Baill, has been shown to have anti-inflammatory effect. The purpose of this study was to evaluate the effect of Sch B on LPS-induced inflammation in microglia and to investigate the molecular targets of Sch B. BV2 cells were stimulated by LPS in the presence or absence of Sch B. The results showed that the levels of TNF-α, IL-6, IL-1β, and PGE2 upregulated by LPS were significantly suppressed by Sch B. LPS-induced NF-κB activation was also inhibited by Sch B...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28299486/the-influence-of-%C3%AE-tocopherol-on-serum-biochemical-markers-during-experimentally-induced-pleuritis-in-rats-exposed-to-dioxin
#9
Ireneusz Całkosiński, Kinga Gostomska-Pampuch, Jacek Majda, Anna Leśków, Maciej Janeczek, Oleg P Melnyk, Andrzej Gamian
Toxicity of dioxins is wide ranging. Amongst the organs, the liver is the most susceptible to damage by dioxins. Damage caused to liver cells results in promoting inflammatory processes. The aim of this work was to evaluate whether high doses of tocopherol will change the inflammatory response, monitored by biochemical indicators, by improving liver function in rats exposed to tetrachlorodibenzo-p-dioxin (TCDD). The study was conducted on a population of female Buffalo rats. The animals were divided into the following groups: Control Group A-representing physiological norms for the studied diagnostic indicators; Control Group B-subjects were administered a 1% ceragenin solution to induce pleuritis; Study Group 1-where rats were administered α-tocopherol acetate for 3 weeks, after which pleuritis was induced; Study Group 2-rats were administered a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), while 3 weeks later, pleuritis was induced; and Study Group 3-rats were administered a single dose of TCDD and next, were administered α-tocopherol acetate for 3 weeks, followed by pleuritis induction...
March 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28285462/2-3-diarylxanthones-as-potential-inhibitors-of-arachidonic-acid-metabolic-pathways
#10
Clementina M M Santos, Daniela Ribeiro, Artur M S Silva, Eduarda Fernandes
In response to an inflammatory stimulus, arachidonic acid (AA), the main polyunsaturated fatty acid present in the phospholipid layer of cell membranes, is released and metabolized to a series of eicosanoids. These bioactive lipid mediators of inflammation arise physiologically through the action of the enzymes 5-lipoxygenase (5-LOX) and cyclooxygenases (constitutive COX-1 and inducible COX-2). It is believed that dual inhibition of 5-LOX and COXs may have a higher beneficial impact in the treatment of inflammatory disorders rather than the inhibition of each enzyme...
March 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28285461/effects-of-sdf-1-cxcr4-on-acute-lung-injury-induced-by-cardiopulmonary-bypass
#11
Hai Shi, Rujian Lu, Shuo Wang, Honglin Chen, Fei Wang, Kun Liu
Acute lung injury (ALI) is one of the most important complications after cardiopulmonary bypass (CPB) and the complex pathophysiology remains to be resolved incomplete. SDF-1/CXCR4 chemokine axis can chemotactically accumulate inflammatory cell to local tissue and regulate the release of inflammatory factors, and SDF-1 has a strong chemotaxis effect on neutrophils with CXCR4. Since CPB animal model was difficult to establish, there was still no report about the effect of SDF-1/CXCR4 on neutrophil chemotaxis in ALI after CPB...
March 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28251449/a20-attenuates-liver-fibrosis-in-nafld-and-inhibits-inflammation-responses
#12
Xiaohan Wang, Luoyan Ai, Qingqing Xu, Changwei Wu, Zhiwei Chen, Dazhi Su, Xiaoke Jiang, Zhuping Fan
We previously reported A20 was able to inhibit lipid accumulation in nonalcoholic steatohepatitis. We want to investigate whether A20 influences liver fibrosis in this study. Liver tissues from patients with hepatic fibrosis (n = 9) and healthy individuals (n = 7) were studied for A20 protein level by immunohistochemistry. A20 messenger RNA (mRNA) and protein level were also analyzed in two murine hepatic fibrosis models: methionine- and choline-deficient (MCD) diet and extrahepatic bile duct ligation (BDL) operation by real-time PCR and western blot...
March 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28251448/effects-of-ergosterol-on-copd-in-mice-via-jak3-stat3-nf-%C3%AE%C2%BAb-pathway
#13
Wang Huan, Zhang Tianzhu, Li Yu, Wang Shumin
The present study was to evaluate the effect of ergosterol (ER) on CS (cigarette smoke)-induced chronic obstructive pulmonary disease (COPD) in mice. Fifty male ICR mice were randomly assigned to five groups: control group, CS group, CS + dexamethasone (Dex, 2 mg/kg) group, CS + ER (ER, 25 mg/kg) group, CS + ER (ER, 50 mg/kg). H&E staining demonstrated that ER inhibited CS-induced pathological injury in lung tissue. Besides, ER could restore the activities of superoxide dismutase (SOD) in serum and in the lung, catalase (CAT) in serum and reduce the content of malondialdehyde (MDA) in serum and in the lung...
March 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28251447/switch-of-steady-state-to-an-accelerated-granulopoiesis-in-response-to-androctonus-australis-hector-venom
#14
Asma Kaddache, Moustapha Hassan, Fatima Laraba-Djebari, Djelila Hammoudi-Triki
Although several studies have shown that scorpion venoms cause a systemic inflammatory response syndrome, little is known about the contribution of the hematopoietic organs. The aim of this study was to investigate the effect of Androctonus australis hector venom on the bone marrow and on local inflammatory mediators, in concordance with the systemic inflammatory reaction elicited in mice. The consequences of a direct interaction of venom with murine bone marrow cells were also assessed by in vitro study. Obtained results showed that the early systemic neutrophilia correlated with a rapid granulocyte mobilization...
March 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28251446/atorvastatin-and-simvastatin-promoted-mouse-lung-repair-after-cigarette-smoke-induced-emphysema
#15
Vanessa Pinho-Ribeiro, Adriana Correa Melo, Emanuel Kennedy-Feitosa, Adriane Graca-Reis, Marina Valente Barroso, Isabella Cattani-Cavalieri, Giovanna Marcella Cavalcante Carvalho, Walter Araújo Zin, Luis Cristóvão Porto, Lycia Brito Gitirana, Manuella Lanzetti, Samuel Santos Valença
Cigarette smoke (CS) induces pulmonary emphysema by inflammation, oxidative stress, and metalloproteinase (MMP) activation. Pharmacological research studies have not focused on tissue repair after the establishment of emphysema but have instead focused on inflammatory stimulation. The aim of our study was to analyze the effects of atorvastatin and simvastatin on mouse lung repair after emphysema caused by CS. Male mice (C57BL/6, n = 45) were divided into the following groups: control (sham-exposed), CSr (mice exposed to 12 cigarettes a day for 60 days and then treated for another 60 days with the vehicle), CSr+A (CSr mice treated with atorvastatin for 60 days), and CSr+S (CSr mice treated with simvastatin for 60 days)...
March 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28247166/progranulin-protects-against-osteonecrosis-of-the-femoral-head-by-activating-erk1-2-pathway
#16
Yingguang Han, Meng Si, Yunpeng Zhao, Yi Liu, Kaiyuan Cheng, Yuedong Zhang, Jialin Jia, Jingkun Li, Lin Nie
The aim of this study was to investigate progranulin (PGRN) expression and its effect in cartilage degradation and in the pathogenesis of osteonecrosis of the femoral head (ONFH). Cartilage specimens were obtained from ONFH and FNF patients and PGRN expression was analyzed by immunohistochemistry, western blot analysis, and RT-PCR. Peripheral blood PGRN level was detected by ELISA. Additionally, primary chondrocytes were cultured and treated with PGRN. Next, the expression of aggrecan and collagen II and the activation of ERK1/2 were detected...
February 28, 2017: Inflammation
https://www.readbyqxmd.com/read/28243950/anti-inflammatory-role-of-pilose-antler-peptide-in-lps-induced-lung-injury
#17
Chunhua Ma, Hongyan Long, Chunhui Yang, Wenjun Cai, Tianzhu Zhang, Wenhai Zhao
The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry weight (W/D) ratio and lung myeloperoxidase (MPO) activity and restored LPS-induced lung histopathological changes. PAP also increased super oxide dismutase (SOD) level and inhibited malondialdehyde (MDA) content and levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) in LPS-stimulated mice...
February 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28233078/establishment-of-a-novel-autoimmune-experimental-model-of-bladder-pain-syndrome-interstitial-cystitis-in-c57bl-6-mice
#18
Xing-Wei Jin, Bo-Ke Liu, Xiang Zhang, Zhong-Hua Zhao, Yuan Shao
The aim of this study is to identify whether vaccinating twice with bladder homogenate can establish a new model of experimental autoimmune cystitis (EAC) in C57BL/6 strain mice. C57BL/6 mice were vaccinated with bladder homogenate in complete Freund's adjuvant (CFA) and boost immunized with bladder homogenate in incomplete Freund's adjuvant (IFA) after 2 weeks were used as the EAC model. Mice immunized with phosphate-buffered saline (PBS) in CFA or IFA were used as the control. Micturition habits and suprapubic-pelvic pain threshold were measured 4 weeks after primary immunization...
February 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28220341/adenovirus-mediated-small-interfering-rna-targeting-tak1-ameliorates-joint-inflammation-with-collagen-induced-arthritis-in-mice
#19
Xinjing Luo, Yongfeng Chen, Guoju Lv, Zhidong Zhou, Jie Chen, Xuanrong Mo, Jiangwen Xie
Transforming growth factor β-activated kinase-1 (TAK1) is a key upstream kinase in cell signaling during inflammation, which regulates the expression of inflammatory mediators. Small interfering RNA (siRNA) against TAK1 offers promise as a potential therapeutic strategy in immune-mediated inflammatory disorder including rheumatoid arthritis. Here, we are to evaluate the therapeutic effects of intra-articular administration of adenoviral-mediated siRNA against TAK1 (ad-siRNA-TAK1) on collagen-induced arthritis (CIA) in mice...
February 21, 2017: Inflammation
https://www.readbyqxmd.com/read/28213866/5-aminosalicylic-acid-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats-by-increasing-the-expression-of-nur77
#20
Ling-Yue Sun, Zong-Ye Cai, Jun Pu, Jian Li, Jie-Yan Shen, Cheng-de Yang, Ben He
The aim of this study is to investigate the effect of 5-aminosalicylic acid (5-ASA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats and its molecular mechanism. Sixty male Sprague-Dawley rats (250-300 g) were evenly randomized into six groups: control group; PAH group induced by MCT intraperitoneal injection (50 mg/kg) on day 1; and four PAH groups treated for 30 days from day 2 with 5-ASA at 50 (5-ASA-50 group), 100 (5-ASA-100 group), 150 (5-ASA-150 group), and 200 mg/kg/day (5-ASA-200 group), respectively...
February 17, 2017: Inflammation
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