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Inflammation

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https://www.readbyqxmd.com/read/28718067/theoretical-and-experimental-in-vivo-study-of-antioxidant-activity-of-crocin-in-order-to-propose-novel-derivatives-with-higher-antioxidant-activity-and-their-delivery-via-nanotubes-and-nanocones
#1
Houshang Najafi, Zeynab Mohamadi Yarijani, Meysam Najafi
In this study, the antioxidant activity of crocin via experimental and theoretical methods was investigated. In order to induce oxidative stress, 30-min renal ischemia and 24-h reperfusion were used in male Wistar rats. Oxidative stress was assessed by measuring tissue malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP). The results showed that following ischemia/reperfusion, the level of MDA was increased and FRAP decreased. Both of these changes were alleviated by crocin administration. The bond dissociation enthalpy and ionization potential values as enthalpies of mechanism of antioxidant activity of crocin were calculated by density functional theory method...
July 17, 2017: Inflammation
https://www.readbyqxmd.com/read/28707248/macrophage-m1-plays-a-positive-role-in-aseptic-inflammation-related-graft-loosening-after-anterior-cruciate-ligament-reconstruction-surgery
#2
Bing Song, Chuan Jiang, Huan Luo, Zhong Chen, Jingyi Hou, Yunfeng Zhou, Rui Yang, Huiyong Shen, Weiping Li
Macrophage-related inflammatory response is one of the main biological factors resulting in failure of anterior cruciate ligament (ACL) reconstruction, although the specific pathomechanism remains to be clarified. Our aim was to investigate the association between graft loosening and macrophage-related inflammation in cases of loosening of reconstructed ACL autografts. Tissue samples were obtained from 21 patients who underwent a second-look arthroscopy within the first year after arthroscopic ACL reconstruction using single-bundle hamstring tendon autografts...
July 13, 2017: Inflammation
https://www.readbyqxmd.com/read/28695368/an-interaction-of-lps-and-rsv-infection-in-augmenting-the-ahr-and-airway-inflammation-in-mice
#3
Na Zhou, Wei Li, Luo Ren, Xiaohong Xie, Enmei Liu
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection (LRTI) in children under 5 years of age, especially infants with severe bronchiolitis. Our preliminary clinical experiments showed that bacterial colonization was commonly observed in children with virus-induced wheezing, particularly in those with recurrent wheezing, suggesting that bacterial colonization with an accompanying viral infection may contribute to disease severity. In most cases, RSV-infected infants were colonized with pathogenic bacteria (mainly Gram-negative bacteria)...
July 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28695367/paeonol-inhibits-il-1%C3%AE-induced-inflammation-via-pi3k-akt-nf-%C3%AE%C2%BAb-pathways-in-vivo-and-vitro-studies
#4
Yiting Lou, Chenggui Wang, Qian Tang, Wenhao Zheng, Zhenhua Feng, Xingfang Yu, Xiaoshan Guo, Jianshun Wang
Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this study was to investigate the anti-inflammatory effects and mechanism of paeonol in IL-1β-induced human OA chondrocytes as well as mice OA models. Human OA chondrocytes were pretreated with different concentrations of paeonol 2 h prior to IL-1β (10 ng/mL) stimulation for 24 h. Nitric oxide (NO) production was determined by Griess method...
July 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28688099/increased-o-linked-n-acetylglucosamine-modification-of-nf-%C3%AE-b-and-augmented-cytokine-production-in-the-placentas-from-hyperglycemic-rats
#5
Vanessa Dela Justina, Jéssica S Gonçalves, Raiany Alves de Freitas, Adriany Dias Fonseca, Gustavo T Volpato, Rita C Tostes, Fernando S Carneiro, Victor Vitorino Lima, Fernanda R Giachini
Inflammation as a result of NF-κB activation may result from the classical (canonical) pathway, with disconnection of the IκB inhibitor and subsequent nuclear translocation or, alternatively, by post-translational modifications of modulatory proteins or NF-κB subunits (non-canonical pathway). We hypothesized that hyperglycemia-induced increased glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) of NF-κB in placental tissue leads to augmented production of pro-inflammatory cytokines, culminating in placental dysfunction and fetal restriction growth...
July 8, 2017: Inflammation
https://www.readbyqxmd.com/read/28688098/the-attenuation-of-14-3-3%C3%AE-is-involved-in-the-caffeic-acid-blocked-lipopolysaccharide-stimulated-inflammatory-response-in-raw264-7-macrophages
#6
Ming Lu, Yi Dai, Miao Xu, Chi Zhang, Yuhong Ma, Ping Gao, Mengying Teng, Kailin Jiao, Guangming Huang, Jianping Zhang, Ye Yang, Zhiping Chu
Inflammation plays important roles in the initiation and progress of many diseases. Caffeic acid (CaA) is a naturally occurring hydroxycinnamic acid derivative, which shows hypotoxicity and diverse biological functions, including anti-inflammation. The molecular mechanisms involved in the CaA-inhibited inflammatory response are very complex; generally, the down-regulated phosphorylation of such important transcriptional factors, for example, nuclear factor κB (NF-κB) and signal transducers and activators of transcription-3 (STAT-3), plays an important role...
July 7, 2017: Inflammation
https://www.readbyqxmd.com/read/28688097/b-lymphocyte-chemoattractant-cxcl13-is-an-indicator-of-acute-gastrointestinal-gvhd-in-murine-model
#7
Yigeng Cao, Xiaoyi Qin, Na Wang, Erlie Jiang, Mingzhe Han, Yongyong Ma, Bin Liang, Kaiyan Yang, Kang Yu, Haige Ye
Gastrointestinal acute graft-vs.-host disease (GI aGVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation and is a major cause of morbidity and mortality. In addition, GI aGVHD is often clinically indistinguishable from other causes of GI dysfunction such as conditioning regimen toxicity, infections, or medications, which complicates the diagnosis. Thus, specific biomarkers are needed to help improve diagnosis and obtain a deeper understanding of the cytokine changes in GI aGVHD...
July 7, 2017: Inflammation
https://www.readbyqxmd.com/read/28685413/telluric-acid-ameliorates-endotoxemic-kidney-injury-in-mice-involvement-of-tlr4-nrf2-and-pi3k-akt-signaling-pathways
#8
Ahmed F Mohamed, Marwa M Safar, Hala F Zaki, Helmy M Sayed
Being one of the most abundant trace elements in the human body, the therapeutic potential of tellurium-based compounds has been a target of interest. Recent reports denoted their redox-modulating and anti-inflammatory activities in experimental endotoxemia. However, their potential nephroprotective effect against endotoxemic kidney injury is yet to be elucidated. This study investigated the possible renoprotective effect of telluric acid (TEL) against lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice, targeting toll-like receptor 4 (TLR4), phosphoinositide 3-kinase (PI3K)/Akt, and nuclear factor-erythroid 2-related factor-2 (Nrf2) pathways as possible mechanistic contributors to TEL's effect...
July 6, 2017: Inflammation
https://www.readbyqxmd.com/read/28674792/adipose-tissue-inflammation-and-oxidative-stress-the-ameliorative-effects-of-vitamin-d
#9
Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Hajiluian, Ghazaleh Nameni, Parviz Shahabi
Obesity is a low-grade inflammatory disease and is associated with numerous comorbidities. The current study was aimed to evaluate the effects of vitamin D administrations on markers of inflammation and oxidative stress in adipose tissue of high-fat diet-induced obese rats. In the beginning of the study, 40 rats were divided into two groups: normal diet and high-fat diet (HFD) for 16 weeks; then, each group was subdivided into two groups including ND, ND + vitamin D, HFD, and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage...
July 3, 2017: Inflammation
https://www.readbyqxmd.com/read/28667503/antipyretic-effects-of-citral-and-possible-mechanisms-of-action
#10
Maycon T Emílio-Silva, Clarissa M D Mota, Clélia A Hiruma-Lima, José Antunes-Rodrigues, Evelin C Cárnio, Luiz G S Branco
Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of lipopolysaccharide ( LPS ) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1β, IL-6, and TNF-α) release, and prostaglandin E2 (PGE2) synthesis (both peripherally and hypothalamic)]...
June 30, 2017: Inflammation
https://www.readbyqxmd.com/read/28667502/lysophosphatidic-acid-protects-against-endotoxin-induced-acute-kidney-injury
#11
Koryun Mirzoyan, Colette Denis, Audrey Casemayou, Marion Gilet, Dimitri Marsal, Dominique Goudounéche, Stanislas Faguer, Jean-Loup Bascands, Joost P Schanstra, Jean-Sébastien Saulnier-Blache
Septic shock is the most common cause of acute kidney injury (AKI), but the underlying mechanisms remain unclear and no targeted therapies exist. Lysophosphatidic acid (LPA) is a bioactive lipid which in vivo administration was reported to mitigate inflammation and injuries caused by bacterial endotoxemia in the liver and lung. The objective of the present study was to determine whether LPA can protect against sepsis-associated AKI. C57BL/6 mice were treated with LPA 18:1 (5 mg/kg, i.p.) 1 h before being injected with the endotoxin lipopolysaccharide (LPS), and AKI was evaluated after 24 h...
June 30, 2017: Inflammation
https://www.readbyqxmd.com/read/28656530/deficiency-of-nalp3-signaling-impairs-liver-regeneration-after-partial-hepatectomy
#12
Tatsuya Ando, Hiroyasu Ito, Ayumu Kanbe, Akira Hara, Mitsuru Seishima
Inflammatory response is required to proceed the optimal liver regeneration after liver injury. Recent reports demonstrated that inflammasomes are involved in the innate immune response. Several NOD-Like receptors (NLRs) participated in the formation of the inflammasomes. NACHT, LRR, and PYD domain-containing protein 3 (NALP3) belongs to the NLR families and recognizes adenosine triphosphate (ATP), crystals, and reactive oxygen species. The present study examined the effect of inflammasomes on the process of liver regeneration using NALP3 knockout (KO) mice...
June 28, 2017: Inflammation
https://www.readbyqxmd.com/read/28656529/il-22-enhances-tnf-%C3%AE-and-il-1-induced-cxcl8-responses-by-intestinal-epithelial-cell-lines
#13
Rebecca S Young, Brody M Wiles, Dennis W McGee
IL-22 is known to induce intestinal epithelial cells (IECs) to produce the chemokine CXCL8. However, IECs exist in a cytokine network during mucosal inflammation, such that IL-22 must act in concert with potent pro-inflammatory cytokines like TNF-α and IL-1. Our studies show that IL-22 alone increased CXCL8 secretion from HT-29 cells, but the levels were minimal compared to that of the cells treated with TNF-α or IL-1 only. More significantly, co-stimulation with IL-22 and TNF-α enhanced both CXCL8 secretion and mRNA levels well over that of TNF-α stimulation alone...
June 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28656528/chitinase-3-like-1-deficient-splenocytes-deteriorated-the-pathogenesis-of-acute-graft-versus-host-disease-via-regulating-differentiation-of-tfh-cells
#14
Zengyao Li, Hao Lu, Jian Gu, Jing Liu, Qin Zhu, Yunjie Lu, Xuehao Wang
Acute graft-versus-host disease (aGVHD) is an intractable complication in transplant patients, limiting the efficacy of this therapy. Chitinase 3-like-1 (CHI3L1), a member of the glycosyl hydrolase 18 family that lacks chitinase activity, plays a critical role in a variety of inflammatory diseases. Here, we investigated the in vitro and in vivo effects of CHI3L1 on the development of aGVHD. In this study, mixed lymphocyte reactions (MLR) in vitro showed that CHI3L1 deficiency in CD4(+) T cell promoted the production of interferon (IFN)-γ and T follicular helper (Tfh)-related cytokines such as interleukin-6 (IL-6) and interleukin-21 (IL-21)...
June 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28656527/erratum-to-fisetin-alleviates-lipopolysaccharide-induced-acute-lung-injury-via-tlr4-mediated-nf-%C3%AE%C2%BAb-signaling-pathway-in-rats
#15
Guang Feng, Ze-Yu Jiang, Bo Sun, Jie Fu, Tian-Zuo Li
No abstract text is available yet for this article.
June 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28646428/effects-of-carvacrol-on-survival-mesenteric-blood-flow-aortic-function-and-multiple-organ-injury-in-a-murine-model-of-polymicrobial-sepsis
#16
Erdem Kamil Ozer, Mustafa Tugrul Goktas, Aysun Toker, Hulagu Bariskaner, Ceyhan Ugurluoglu, Alper Bektas Iskit
Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Wistar rats were allocated into the following four groups: Sham, CLP, Sham + CRV, and CLP + CRV. The animals were orally administered with CRV (80 mg/kg/day) or vehicle (corn oil; 1 mL/kg/day) for 7 days...
June 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28646427/tanshinone-iia-attenuates-atherosclerosis-in-apolipoprotein-e-knockout-mice-infected-with-porphyromonas-gingivalis
#17
Yan Xuan, Yue Gao, Hao Huang, Xiaoxuan Wang, Yu Cai, Qing Xian Luan
Tanshinone IIA (TSA), a pharmacologically active component isolated from Danshen, may prevent cardiovascular diseases due to its anti-inflammatory, anti-oxidative, and anti-adipogenic effects. Porphyromonas gingivalis, a major periodontal pathogen, may contribute to the progression of atherosclerosis. Here, we studied the effects of TSA on atherosclerosis in ApoE(-/-) mice with P. gingivalis infection. Eight-week-old ApoE(-/-) mice were randomized to (a) phosphate-buffered saline (PBS), (b) P. gingivalis, and (c) P...
June 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28639050/paeoniflorin-suppressed-high-glucose-induced-retinal-microglia-mmp-9-expression-and-inflammatory-response-via-inhibition-of-tlr4-nf-%C3%AE%C2%BAb-pathway-through-upregulation-of-socs3-in-diabetic-retinopathy
#18
Su-Hua Zhu, Bing-Qian Liu, Mao-Juan Hao, Yi-Xin Fan, Cheng Qian, Peng Teng, Xiao-Wei Zhou, Liang Hu, Wen-Tao Liu, Zhi-Lan Yuan, Qing-Ping Li
Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the destruction of the integrity of the blood-retinal barrier (BRB) associated with the development of DR. MMP-9 was also considered important for regulating inflammatory responses. Paeoniflorin, a monoterpene glucoside, has a potent immunomodulatory effect on microglia...
June 21, 2017: Inflammation
https://www.readbyqxmd.com/read/28634844/thrombospondin-1-production-regulates-the-inflammatory-cytokine-secretion-in-thp-1-cells-through-nf-%C3%AE%C2%BAb-signaling-pathway
#19
Tian Xing, Yao Wang, Wen-Jie Ding, Yuan-Ling Li, Xiao-Dong Hu, Cong Wang, Ao Ding, Ji-Long Shen
Thrombospondin-1 (TSP-1) is upregulated in several inflammatory diseases. Recent data have shown that macrophages from TSP-1-deficient mice have a reduced inflammatory phenotype, suggesting that TSP-1 plays a part in macrophage activation. DNA microarray approach revealed that Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) may induce the enhanced TSP-1 expression in human monocytes, suggesting a role of TSP-1-mediated pathogenesis in periodontitis. Until recently, the function of TSP-1 has been a matter of debate...
June 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28620821/administration-of-exogenous-melatonin-after-the-onset-of-systemic-inflammation-is-hardly-beneficial
#20
Lisa Brencher, Maren Oude Lansink, Katharina Effenberger-Neidnicht
Melatonin improves survival and functional impairment including hemolysis, thrombocytopenia, and hypotension when administered in a prophylactic manner or early after initiation of sepsis or endotoxemia. In the present study, melatonin was given not before first symptoms of systemic inflammation became manifest. Lipopolysaccharide was infused at a rate of 0.5 mg/kg × h to induce systemic inflammation in male Wistar rats. Melatonin (single dose 3 mg/kg × 15 min) was intravenously administered 180 and 270 min after starting of the lipopolysaccharide infusion...
June 15, 2017: Inflammation
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