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Inflammation

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https://www.readbyqxmd.com/read/30519926/schisandrin-b-improves-the-renal-function-of-iga-nephropathy-rats-through-inhibition-of-the-nf-%C3%AE%C2%BAb-signalling-pathway
#1
Jian-Hua Qin, Jia-Ru Lin, Wen-Fei Ding, Wei-Hua Wu
Schisandrin B (SchB) is an active compound extracted from the Chinese herb Schisandra chinensis and shows excellent anti-inflammatory activity. This study was performed to examine the effects of SchB in a rat model of IgA nephropathy (IgAN). IgAN was established in Sprague-Dawley rats by immunization with lipopolysaccharide (LPS), bovine serum albumin, and carbon tetrachloride. Renal function was evaluated by determining the levels of urinary red blood cells, proteinuria, blood urea nitrogen (BUN), and creatinine (Cr)...
December 5, 2018: Inflammation
https://www.readbyqxmd.com/read/30506423/porphyromonas-gingivalis-induced-mif-regulates-intercellular-adhesion-molecule-1-expression-in-ea-hy926-cells-and-monocyte-endothelial-cell-adhesion-through-the-receptors-cd74-and-cxcr4
#2
Yun Wu, Wanyue Xu, Jingya Hou, Yanqing Liu, Rong Li, Jingbo Liu, Chen Li, Xiaolin Tang, Li Lin, Yaping Pan, Dongmei Zhang
Porphyromonas gingivalis (P. gingivalis) is an important pathogen that contributes to periodontal disease and causes infections that promote the progression of atherosclerosis. Our previous studies showed that macrophage migration inhibitory factor (MIF) facilitates monocyte adhesion to endothelial cells by regulating the expression of intercellular adhesion molecule-1 (ICAM-1) in P. gingivalis-infected endothelial cells. However, the detailed pathological role of MIF has yet to be elucidated in this context...
December 3, 2018: Inflammation
https://www.readbyqxmd.com/read/30506108/low-level-laser-therapy-prevents-treadmill-exercise-induced-progression-of-arthrogenic-joint-contracture-via-attenuation-of-inflammation-and-fibrosis-in-remobilized-rat-knees
#3
Akinori Kaneguchi, Junya Ozawa, Kengo Minamimoto, Kaoru Yamaoka
We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3 weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W + L) groups. Total and arthrogenic contractures were assessed by restrictions of passive range of motion (ROM) before (m-ROM) and after myotomy (a-ROM), respectively...
December 1, 2018: Inflammation
https://www.readbyqxmd.com/read/30506107/schisandrin-b-attenuates-inflammation-in-lps-induced-sepsis-through-mir-17-5p-downregulating-tlr4
#4
Zhi-Rong Ji, Wei-Liang Xue, Ling Zhang
To investigate the mechanism of Schisandrin B (Sch B) on the inflammation in LPS-induced sepsis. Sepsis mouse model was established by injecting LPS. qRT-PCR and western blot were used to measure the expression of miR-17-5p and TLR4. ELISA was used to test the concentrations of IL-1β and TNF-α. Sch B could increase miR-17-5p expression, promote inflammation, and decrease TLR4 expression in sepsis mice and LPS-induced macrophages. Moreover, miR-17-5p could negatively regulate TLR4. Overexpression of miR-17-5p suppressed the concentrations of inflammatory factors (IL-1β and TNF-α) in LPS induced-macrophages, while pcDNA-TLR4 could change the inhibition effect...
December 1, 2018: Inflammation
https://www.readbyqxmd.com/read/30506106/dusp6-inhibitor-e-z-bci-hydrochloride-attenuates-lipopolysaccharide-induced-inflammatory-responses-in-murine-macrophage-cells-via-activating-the-nrf2-signaling-axis-and-inhibiting-the-nf-%C3%AE%C2%BAb-pathway
#5
Fan Zhang, Bufu Tang, Zijiao Zhang, Di Xu, Guowu Ma
Macrophages play a fundamental role in human chronic diseases such as rheumatoid arthritis, atherosclerosis, and cancer. In the present study, we demonstrated that dual-specificity phosphatase 6 (DUSP6) was upregulated by lipopolysaccharide (LPS) treatment of macrophages. (E/Z)-BCI hydrochloride (BCI) functions as a small molecule inhibitor of DUSP6, and BCI treatment inhibited DUSP6 expression in LPS-activated macrophages. BCI treatment inhibited LPS-triggered inflammatory cytokine production, including IL-1β and IL-6, but not TNF-α, and also affected macrophage polarization to an M1 phenotype...
December 1, 2018: Inflammation
https://www.readbyqxmd.com/read/30506105/immunometabolism-another-road-to-sepsis-and-its-therapeutic-targeting
#6
REVIEW
Vijay Kumar
Sepsis is a major health problem all over the world. Despite its existence since the time of Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units. The most current US FDA-approved drug called recombinant human activated protein C or Drotrecogin-α is also failed in clinical trials and showed similar effects as placebo. The epidemiological data and studies have indicated sepsis as a major socioeconomic burden all over the world...
December 1, 2018: Inflammation
https://www.readbyqxmd.com/read/30488142/insulin-antagonizes-lps-induced-inflammatory-responses-by-activating-sr-a1-erk-axis-in-macrophages
#7
Liu Zhu, Lei Fan, Yaqin Zhu, Yan Wang, Hui Bai, Qing Yang, Jingjing Ben, Hanwen Zhang, Xiaoyu Li, Xudong Zhu, Qi Chen
Insulin is a key regulator of metabolism and inflammation in the body. However, the mechanism of the anti-inflammatory effect of insulin is not fully understood. In the present study, we investigated the role of the class A1 scavenger receptor (SR-A1), a prototypic member of the pattern recognition receptor family, in the insulin-mediated suppression of inflammatory responses in macrophages. Our murine in vivo studies show that insulin can attenuate lipopolysaccharide (LPS)-induced endotoxemia in a SR-A1-dependent manner, and this was consistent with our in vitro results which demonstrate that the SR-A1 is necessary for insulin to antagonize the LPS-induced inflammatory responses in macrophages...
November 29, 2018: Inflammation
https://www.readbyqxmd.com/read/30488141/peroxisome-proliferator-activated-receptor-%C3%AE-agonist-rosiglitazone-protects-blood-brain-barrier-integrity-following-diffuse-axonal-injury-by-decreasing-the-levels-of-inflammatory-mediators-through-a-caveolin-1-dependent-pathway
#8
Yonglin Zhao, Xing Wei, Jinning Song, Ming Zhang, Tingqin Huang, Jie Qin
Our early experiments confirmed that rosiglitazone (RSG), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, had therapeutic potential for the treatment of diffuse axonal injury (DAI) by inhibiting the expression of amyloid-beta precursor protein and reducing the loss and abnormal phosphorylation of tau, but the underlying mechanisms were not fully defined. In this study, we aimed to investigate a possible role for PPARγ in the protection of blood-brain barrier (BBB) integrity in a rat model of DAI, and the underlying mechanisms...
November 28, 2018: Inflammation
https://www.readbyqxmd.com/read/30484006/degradation-products-of-polydopamine-restrained-inflammatory-response-of-lps-stimulated-macrophages-through-mediation-tlr-4-myd88-dependent-signaling-pathways-by-antioxidant
#9
Liang Jin, Feng Yuan, Chenxin Chen, Jing Wu, Ruolan Gong, Guangyin Yuan, Hui Zeng, Jia Pei, Tongxin Chen
Polydopamine (PDA) has a promising application as coating of biomaterials due to its favorable degradability and bioadaptability. However, its bioactivity, such as anti-inflammatory capacity, was still little known. Herein, we investigated whether degradable products of PDA could affect inflammatory response in lipopolysaccharide (LPS)-stimulated human THP-1-derived macrophages. The supernatants containing degradation products of PDA, annotated as PDA extracts, were collected after PDA being immersed in cell culture medium for 3 days...
November 27, 2018: Inflammation
https://www.readbyqxmd.com/read/30484005/interleukin-il-35-suppresses-il-6-and-il-8-production-in-il-17a-stimulated-human-periodontal-ligament-cells
#10
Satoru Shindo, Yoshitaka Hosokawa, Ikuko Hosokawa, Hideki Shiba
Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 is reported to suppress IL-17A-producing helper T (Th17) cell activation. IL-17A is related to progression of periodontitis. Furthermore, IL-35 and IL-17A are detected in human gingival crevicular fluid. However, the effect of IL-35 and interaction between IL-35 and IL-17A on pro-inflammatory cytokine production in human periodontal resident cells are still unclear. The aim of this study was to clarify the effect of IL-35 on IL-6 and IL-8 production in human periodontal ligament cells (HPDLCs) stimulated with IL-17A...
November 27, 2018: Inflammation
https://www.readbyqxmd.com/read/30484004/metabolomics-analysis-reveals-therapeutic-effects-of-%C3%AE-mangostin-on-collagen-induced-arthritis-in-rats-by-down-regulating-nicotinamide-phosphoribosyltransferase
#11
Kui Yang, Qin Yin, Qingcheng Mao, Sheng Dai, Lin Wang, Jiyang Dong, Jian Zuo
α-Mangostin (MAN) is a bioactive compound isolated from pericarp of mangosteen (Garcinia mangostana Linn.) with significant anti-rheumatic potentials. The purpose of this study was to explore the mechanisms underlying its therapeutic effects on collagen-induced arthritis (CIA) in rats with metabolomics approaches. Therapeutic effects of MAN on CIA were assessed by radiographic, histological, and immunohistochemical methods. Metabolic profiles of rats were characterized based on UPLC-MS/MS analysis of urine samples, followed by verification in HFLS-RA cells using a variety of toxicological and biochemical assays...
November 27, 2018: Inflammation
https://www.readbyqxmd.com/read/30467622/the-expression-of-cxcl10-cxcr3-and-effect-of-the-axis-on-the-function-of-t-lymphocyte-involved-in-oral-lichen-planus
#12
Jiaxiang Fang, Chen Wang, Chen Shen, Jing Shan, Xuewei Wang, Lin Liu, Yuan Fan
The etiology of oral lichen planus (OLP) is still not clear. The purpose of this study was to explore the role of CXC chemokine receptor 3(CXCR3) and its ligand CXC motif chemokine 10(CXCL10) in the pathogenesis of OLP. We examined the expression of CXCR3 and CXCL10 in OLP patients and healthy controls by quantitative real-time PCR, Western blotting, ELISAs, and immunohistochemistry, respectively. Moreover, we detected the effects of CXCL10/CXCR3 axis on T lymphocyte migration, proliferation and apoptosis by Transwell assays, CCK8 assays, and flow cytometry...
November 22, 2018: Inflammation
https://www.readbyqxmd.com/read/30467621/effects-of-human-interleukin-10-on-ventilator-associated-lung-injury-in-rats
#13
Jinzhuan Chen, Jianqing Lin, Huiqin Luo, Minjie Li
Ventilator-induced lung injury (VILI) is one of the most serious complications of mechanical ventilation (MV) and can increase the mortality of patients with acute respiratory distress syndrome (ARDS). This work aimed to test the hypothesis that the anti-inflammatory properties of human interleukin-10 (hIL-10) can reduce VILI. Thirty-six healthy male Sprague-Dawley rats were randomly assigned into three groups (n = 12) as follows: a control group, a VILI group, and a hIL-10 group. Lung function was evaluated by oxygenation index and pulmonary edema, and morphological changes associated with lung injury were assessed by HE staining and quantitative histological lung injury score...
November 22, 2018: Inflammation
https://www.readbyqxmd.com/read/30465301/neutrophil-cytosolic-factor-1-contributes-to-the-development-of-sepsis
#14
Dei-Fang Chen, Xiu-Zhen Cui, Wen-Ming Cao, Wen Meng
To identify differentially expressed genes in sepsis and potential key role of reactive oxygen species (ROS) genes associated with sepsis. Gene expression dataset was available from GSE46599. Firstly, we screened the differentially expressed genes between sepsis and healthy samples. Then, the Database for Annotation, Visualization and Integrated Discovery (DAVID) online tools were utilized to perform gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses at the functional level...
November 21, 2018: Inflammation
https://www.readbyqxmd.com/read/30446982/breast-implant-texturization-does-not-affect-the-crosstalk-between-msc-and-alcl-cells
#15
Monia Orciani, Miriam Caffarini, Matteo Torresetti, Anna Campanati, Piercamillo Parodi, Giovanni Di Benedetto, Roberto Di Primio
In the last decade, there has been a growing interest about the possible association between anaplastic large cell lymphoma (ALCL) and breast implants (BIA-ALCL). Many variables, such as breast implants texturization, have been investigated. Breast implants often lead to the formation of a periprosthetic capsule, characterized by inflammation. The presence of the inflamed capsule has been found in the majority of patients with BIA-ALCL. Inflammation may be sustained or counteracted by mesenchymal stem cells (MSCs) by the secretion of pro- or anti-inflammatory cytokines...
November 16, 2018: Inflammation
https://www.readbyqxmd.com/read/30430362/1-25-dihydroxy-vitamin-d-3-attenuates-the-oxidative-stress-mediated-inflammation-induced-by-pm-2-5-via-the-p38-nf-%C3%AE%C2%BAb-nlrp3-pathway
#16
Lili Xin, Bizhong Che, Bingzhong Zhai, Qiulin Luo, Chen Zhang, Jianshu Wang, Shengli Wang, Guoqiang Fan, Zhiyong Liu, Jialiang Feng, Zengli Zhang
Vitamin D3 is reported to be involved in the regulation of inflammatory processes. In this study, biomarkers related to oxidative stress and inflammation were investigated to clarify the protective effects and possible mechanism of 1,25-dihydroxy vitamin D3 (1,25-(OH)2 D3 ) on PM2.5 -induced inflammatory response. In the in vitro study using human bronchial epithelial (HBE) cells, aqueous extracts of PM2.5 could induce oxidative damage which is characterized by significant increases in production of reactive oxygen species, malonaldehyde concentration, and protein expression of HSPA1A and HO-1...
November 14, 2018: Inflammation
https://www.readbyqxmd.com/read/30415433/correction-to-sam68-promotes-invasion-migration-and-proliferation-of-fibroblast-like-synoviocytes-by-enhancing-the-nf-%C3%AE%C2%BAb-p65-pathway-in-rheumatoid-arthritis
#17
Weiwei Sun, Rongqing Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Unfortunately the author name, Rongqing Qin, was wrongly spelt as Rongqin Qin in the original version. It has been updated and the complete corrected author group is given below.
November 10, 2018: Inflammation
https://www.readbyqxmd.com/read/30413905/locally-used-antibiotics-for-spinal-infection-prophylaxis-and-their-effects-on-epidural-fibrosis-an-experimental-laminectomy-study-in-rats-using-rifamycin-and-gentamycin
#18
Nese Keser, Merih Is, Duygu Ceman, Adnan Somay
The study aims to assess the effects of antibiotics (ABs), which are typically used in spinal infection prophylaxis, on the formation of epidural fibrosis (EF). Specifically, we investigated the effect of rifamycin and gentamycin on EF formation in laminectomized rats. Thirty-two rats were randomly and equally divided into four groups as follows: laminectomy and physiological saline (0.9% NaCl) solution (control); laminectomy and rifamycin; laminectomy and gentamicin; and laminectomy and a mixture of rifamycin and gentamicin...
November 10, 2018: Inflammation
https://www.readbyqxmd.com/read/30411213/acute-exposure-to-diesel-biodiesel-particulate-matter-promotes-murine-lung-oxidative-stress-by-nrf2-ho-1-and-inflammation-through-the-nf-kb-tnf-%C3%AE-pathways
#19
Isabella Cattani-Cavalieri, Samuel Santos Valenca, Manuella Lanzetti, Giovanna Marcella Cavalcante Carvalho, Walter Araújo Zin, Andréa Monte-Alto-Costa, Luís Cristóvão Porto, Bruna Romana-Souza
Air pollution caused by fuel burning contributes to respiratory impairments that may lead to death. We aimed to investigate the effects of biodiesel (DB) burning in mouse lungs. DB particulate matter was collected from the exhaust pipes of a bus engine. Mice were treated with 250 μg or 1000 μg of DB particulate matter by intranasal instillation over 5 consecutive days. We demonstrated that DB particulate matter penetrated the lung in the 250-μg and 1000-μg groups. In addition, the DB particulate matter number in pulmonary parenchyma was 175-fold higher in the 250-μg group and 300-fold higher in the 1000-μg group compared to control mice...
November 9, 2018: Inflammation
https://www.readbyqxmd.com/read/30411212/alcohol-binge-reduces-systemic-leukocyte-activation-and-pulmonary-pmn-infiltration-after-blunt-chest-trauma-and-hemorrhagic-shock
#20
Niklas Franz, Scott Dieteren, Kernt Köhler, Katharina Mörs, Ramona Sturm, Ingo Marzi, Mario Perl, Borna Relja, Nils Wagner
Blunt chest (thoracic) trauma (TxT) and hemorrhagic shock (HS)-induced local and systemic inflammation with increased neutrophil activity often result in an impaired organ function. Next to increasing the trauma risk, binge drinking causes anti-inflammatory effects due to immunomodulatory properties of alcohol (ethanol, EtOH). The impact of clinically relevant acute binge drinking scenario on local and systemic inflammatory changes, notably regarding the activity and longevity of leukocytes, has been analyzed in a combinatory trauma model of TxT + H/R...
November 9, 2018: Inflammation
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