Xin Zhou, Kaini Zhang, Chen Wang, Yunfei Teng, Peihong Yu, Wei Cai, Wenjie Gao, Min Li, Ying Ding, Peng Sun, Fang Chen, Yipin Wang, Juan Ma, Noriaki Maeshige, Xiaoqi Ma, Qingguo Li, Xiubin Liang, Yaqin Zhang, Dongming Su
While previous studies have indicated the involvement of Isthmin 1 (ISM1), a secreted protein, in cancer development, the precise mechanisms have remained elusive. In this study, we unveiled that ISM1 is significantly overexpressed in both the blood and tissue samples of colorectal cancer (CRC) patients, correlating with their poor prognosis. Functional experiments demonstrated that enforced ISM1 expression significantly enhances CRC proliferation, migration, invasion and tumor growth. Notably, our investigation reveals an interaction of ISM1 with epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase (RTK) family of CRC cells...
April 7, 2024: Cancer Letters