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Cancer Letters

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https://www.readbyqxmd.com/read/28089831/monomethyltransferase-setd8-regulates-breast-cancer-metabolism-via-stabilizing-hypoxia-inducible-factor-1%C3%AE
#1
Run Huang, Yang Yu, Xiangyun Zong, Xiaolin Li, Lisi Ma, Qi Zheng
SETD8 is a methyltransferase that specifically catalyzes the monomethylation of lysine 20 on histone H4. Previous studies have demonstrated that SETD8 is associated with proper cell cycle progression, DNA damage response, and transcriptional regulation. A recent study revealed that SETD8 played an important role in epithelial-mesenchymal transition (EMT) in association with TWIST and enhanced metastatic potential of breast cancer cells. However, the contribution of SETD8 to metabolism reprogramming, one hallmark of cancer, has never been reported...
January 13, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28089830/tumor-suppressor-spop-ubiquitinates-and-degrades-egln2-to-compromise-growth-of-prostate-cancer-cells
#2
Linli Zhang, Shan Peng, Xiangpeng Dai, Wenjian Gan, Xin Nie, Wenyi Wei, Guoqing Hu, Jianping Guo
EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (HIFα) in tumors, the functional significance and the upstream regulatory mechanisms of EglN2, especially in prostate cancer setting, remain largely unclear. Here, we demonstrated that dysregulation of EglN2 facilitated prostate cancer growth both in cells and in vivo...
January 13, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28089834/recent-clinical-trials-utilizing-chimeric-antigen-receptor-t-cells-therapies-against-solid-tumors
#3
Shuanglin Han, Olivier Latchoumanin, Guang Wu, Gang Zhou, Lionel Hebbard, Jacob George, Liang Qiao
Chimeric antigen receptors (CARs) are a series of manufactured receptors that have the capacity of binding to specific antigens expressed on surface of tumor cells. A CAR normally has an extracellular antigen recognition domain derived from single variable chain of a monoclonal antibody, a transmembrane domain and an intracellular T cell activation domain. During the last decade, CAR-T cells were demonstrated to possess great therapeutic effects on hematological malignancies. However, strategies using CAR-T cells to treat solid tumors have been hindered by considerable obstacles including "on tissue off target" effects and cytokine storm syndrome...
January 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28089833/rufy3-promotes-metastasis-through-epithelial-mesenchymal-transition-in-colorectal-cancer
#4
Ruyi Xie, Jing Wang, Weimei Tang, Yueqiao Li, Ying Peng, Hui Zhang, Guangnan Liu, Xiaoting Huang, Jinjun Zhao, Aimin Li, Wei Gong, Ye Chen, Yuexin Ren, Yadong Wang, Guoxin Li, Side Liu, Jide Wang
Rufy3 is a RUN domain-containing protein that has been associated with gastric cancers; however, the role of Rufy3 in the progression of colorectal cancer (CRC) remains unknown. We demonstrated that Rufy3 expression was higher in 11/12 fresh CRC tissues than in adjacent normal tissues. Rufy3 induced elevated expression and transactivity of four major oncogenes in CRC. Moreover, siRNA-mediated repression of Rufy3 induced G0/G1 cell cycle arrest, and Rufy3 overexpression enhanced CRC cell proliferation in vitro and in vivo...
January 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28089832/androgen-receptor-ar-promotes-clear-cell-renal-cell-carcinoma-ccrcc-migration-and-invasion-via-altering-the-circhiat1-mir-195-5p-29a-3p-29c-3p-cdc42-signals
#5
Kefeng Wang, Yin Sun, Wei Tao, Xiang Fei, Chawnshang Chang
Increasing evidence has demonstrated that androgen receptor (AR) plays important roles to promote the metastasis of clear cell renal cell carcinoma (ccRCC). The detailed mechanisms, especially how AR functions via altering the circular RNAs (circRNAs) remain unclear. Here we identified a new circRNA (named as circHIAT1) whose expression was lower in ccRCCs than adjacent normal tissues. Targeting AR could suppress ccRCC cell progression via increasing circHIAT1 expression. ChIP assay and luciferase assay demonstrated that AR suppressed circHIAT1 expression via regulating its host gene (HIAT1) expression at the transcriptional level...
January 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28089829/resveratrol-and-capsaicin-used-together-as-food-complements-reduce-tumor-growth-and-rescue-full-efficiency-of-low-dose-gemcitabine-in-a-pancreatic-cancer-model
#6
Véronique Vendrely, Evelyne Peuchant, Etienne Buscail, Isabelle Moranvillier, Benoit Rousseau, Aurélie Bedel, Aurélia Brillac, Hubert de Verneuil, François Moreau-Gaudry, Sandrine Dabernat
Pancreatic adenocarcinoma, highly resistant to all current anti-cancer treatments, necessitates new approaches promoting cell death. We hypothesized that combined actions of several Bioactive Food Components (BFCs) might provide specific lethal effect towards tumor cells, sparing healthy cells. Human tumor pancreatic cell lines were tested in vitro for sensitivity to resveratrol, capsaicin, piceatannol, and sulforaphane cytotoxic effects. Combination of two or three components showed striking synergetic effect with gemcitabine in vitro...
January 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28043914/bay-1143269-a-novel-mnk1-inhibitor-targets-oncogenic-protein-expression-and-shows-potent-anti-tumor-activity
#7
Susann Santag, Franziska Siegel, Antje M Wengner, Claudia Lange, Ulf Bömer, Knut Eis, Florian Pühler, Philip Lienau, Linda Bergemann, Martin Michels, Franz von Nussbaum, Dominik Mumberg, Kirstin Petersen
The initiation of mRNA translation has received increasing attention as an attractive target for cancer treatment in the recent years. The oncogenic eukaryotic translation initiation factor 4E (eIF4E) is the major substrate of MAP kinase-interacting kinase 1 (MNK1), and it is located at the junction of the cancer-associated PI3K and MAPK pathways. The fact that MNK1 is linked to cell transformation and tumorigenesis renders the kinase a promising target for cancer therapy. We identified a novel small molecule MNK1 inhibitor, BAY 1143269, by high-throughput screening and lead optimization...
December 31, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28043913/sri36160-is-a-specific-inhibitor-of-wnt-%C3%AE-catenin-signaling-in-human-pancreatic-and-colorectal-cancer-cells
#8
Yonghe Li, Patsy G Oliver, Wenyan Lu, Vibha Pathak, Sivaram Sridharan, Corinne E Augelli-Szafran, Donald J Buchsbaum, Mark J Suto
Activation of Wnt/β-catenin signaling is associated with pancreatic and colorectal cancer, among others. To-date, there are no FDA-approved small molecule Wnt/β-catenin inhibitors and many past efforts resulted in compounds with undesirable off-target effects. We recently identified a series of benzimidazole analogs as potent inhibitors of Wnt/β-catenin signaling. Here, we show that the lead compound SRI36160 displayed selective Wnt inhibition and potent antiproliferative activity in pancreatic and colorectal cancer cells...
December 30, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28043912/ultrasound-mediated-destruction-of-oxygen-and-paclitaxel-loaded-dual-targeting-microbubbles-for-intraperitoneal-treatment-of-ovarian-cancer-xenografts
#9
Tingting Luo, Jiangchuan Sun, Shenyin Zhu, Juan He, Lan Hao, Linlin Xiao, Yi Zhu, Qianqian Wang, Xin Pan, Zhigang Wang, Shufang Chang
Folate receptor (FR) is overexpressed in many epithelial cancers and tumor-associated macrophages (TAMs), which enable it to function as an appropriate target for cancer treatment. We have successfully synthesized multifunctional folate-targeted and oxygen/paclitaxel loaded microbubbles (TOPLMBs) for ultrasound (US) mediated delivery for combination therapy in an intraperitoneal ovarian cancer xenograft model. The TOPLMBs target both ovarian cancer cells and TAMs and provide a promising drug delivery strategy for the combination treatment of ovarian cancer and tumor microenvironment...
December 30, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28043911/mir-181a-5p-promotes-the-progression-of-gastric-cancer-via-rassf6-mediated-mapk-signalling-activation
#10
Yushuai Mi, Dongyuan Zhang, Weiliang Jiang, Junyong Weng, Chongzhi Zhou, Kejian Huang, Huamei Tang, Yang Yu, Xisheng Liu, Weiyingqi Cui, Meng Zhang, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng, Senlin Zhao, Yugang Wen
We previously discovered that Ras association domain family member 6 (RASSF6) was downregulated and predicted poor prognosis in GC patients. However, the mechanisms of the down regulation of RASSF6 in GC remained unclear. Increasing evidence indicates that dysregulation of microRNAs promotes the progression of cancer through the repression of tumour suppressors. Here, we identified miR-181a-5p as a novel regulator of RASSF6 in GC. Functionally, ectopic expression or silencing of miR-181a-5p, respectively, promoted or inhibited GC cell proliferation, colony formation and cell cycle transition, as well as enhanced or prevented the invasion, metastasis of GC cells and epithelial to mesenchymal transition of GC cells in vitro and in vivo...
December 30, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28043910/metformin-inhibits-castration-induced-emt-in-prostate-cancer-by-repressing-cox2-pge2-stat3-axis
#11
Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, Jun Jiang
Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metastasis. In this study, we demonstrated that metformin is capable of inhibiting prostate cancer cell migration and invasion by repressing EMT evidenced by downregulating the mesenchymal markers N-cadherin, Vimentin, and Twist and upregulating the epithelium E-cadherin...
December 30, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28041977/induction-of-the-mcp-chemokine-cluster-cascade-in-the-periphery-by-cancer-cell-derived-ccl3
#12
Elena Farmaki, Vimala Kaza, Athanasios G Papavassiliou, Ioulia Chatzistamou, Hippokratis Kiaris
The induction of localized pro-inflammatory niches in the periphery is instrumental in metastasis. In order to better understand how tumors engage distal sites and activate a pro-inflammatory response we utilized syngeneic breast cancers as a model and showed that soluble factors from the neoplastic epithelium activate the expression of the monocyte chemoattractive protein (MCP) chemokines of the mouse 11C cluster that include Ccl1, Ccl2, Ccl7, Ccl8, Ccl11 and Ccl12. Tissues such as the lungs and the brain, that are more prone to colonization by breast cancer cells, were more sensitive to MCP cluster chemokine induction than others such as the liver...
December 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28040547/lemur-tyrosine-kinase-2-lmtk2-is-a-determinant-of-cell-sensitivity-to-apoptosis-by-regulating-the-levels-of-the-bcl2-family-members
#13
Annalisa Conti, Maria Teresa Majorini, Enrico Fontanella, Alberto Bardelli, Mauro Giacca, Domenico Delia, Miguel Mano, Daniele Lecis
Using a high-throughput approach, we identified lemur tyrosine kinase 2 (LMTK2) as a novel determinant of cell sensitivity to TRAIL. LMTK2 is a poorly characterized serine/threonine kinase believed to play a role in endosomal membrane trafficking and neuronal physiology, and recently found to be mutated in diverse tumor types. We show that LMTK2 silencing sensitizes immortalized epithelial cells and cancer cells to TRAIL, and this phenomenon is accompanied by changes in the expression of BCL2 family members...
December 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28040546/whole-genome-sequencing-reveals-the-mutational-landscape-of-metastatic-small-cell-gallbladder-neuroendocrine-carcinoma-gb-scnec
#14
Maolan Li, Fatao Liu, Yijian Zhang, Xiangsong Wu, Wenguang Wu, Xu-An Wang, Shuai Zhao, Shibo Liu, Haibin Liang, Fei Zhang, Qiang Ma, Shanshan Xiang, Huaifeng Li, Lin Jiang, Yunping Hu, Wei Gong, Yun Zhang, Tieliang Ma, Kai Zhang, Yun Liu, Yingbin Liu
Small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC) is a relatively rare histological type of gallbladder cancer, and the genomic landscape of GB-SCNEC is rarely considered in treatment decisions. We performed whole-genome sequencing on an advanced case of GB-SCNEC. We identified approximately 900 high-quality somatic single nucleotide variants (SNVs) and small insertions and deletions (INDELs), 109 of which were shared by both the primary and metastatic tumor tissues. Somatic non-synonymous coding variations with damaging impact in HMCN1 and CDH10 were observed in both the primary and metastatic tissue specimens...
December 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28040545/multifunctional-near-infrared-dye-magnetic-nanoparticles-for%C3%A2-bioimaging-and-cancer-therapy
#15
Xiaoyang Hou, Huige Zhou, Liming Wang, Jianqin Tang, Guan Jiang, Chunying Chen, Yanqun Liu
Theranostics based on nanoparticles have developed rapidly in the past decade and have been widely used in the diagnosis and treatment of liver cancer, breast cancer, and other tumors. However, for skin cancers, there are limited studies. In the present study, we successfully synthesized a theranostic nanoparticle by grating IR820 onto the surface of chitosan-coated magnetic iron oxide, IR820-CS-Fe3O4, showing an excellent magnetic resonance imaging (MRI) capability and cytotoxic effects against melanoma under irradiation with a near-infrared (NIR) laser (808 nm) in vitro...
December 29, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28038969/corrigendum-to-an-association-of-dnmt3b-protein-expression-with-p16ink4a-promoter-hypermethylation-in-non-smoking-female-lung-cancer-with-human-papillomavirus-infection-cancer-lett-226-1-2005-aug-8-77-84
#16
Torng-Sen Lin, Huei Lee, Ruei-A Chen, Ming-Lin Ho, Chia-Yu Lin, Ya-Hui Chen, Yi Yu Tsai, Ming-Chih Chou, Ya-Wen Cheng
No abstract text is available yet for this article.
December 27, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28034805/cd133-confers-cancer-stem-like-cell-properties-by-stabilizing-egfr-akt-signaling-in-hepatocellular-carcinoma
#17
Jae-Woo Jang, Yeonhwa Song, Se-Hyuk Kim, Jin-Sun Kim, Kang Mo Kim, Eun Kyung Choi, Joon Kim, Haeng Ran Seo
Hepatocellular carcinoma (HCC) is the seventh most common malignant tumor and the third leading cause of cancer-related death in the world. Cancer stem cells (CSCs) are small subpopulation of cells within tumors that drive chemoresistance and tumor recurrence in various cancers. We characterized CSCs in primary HCC and identified CD133 as a CSC surface marker. CD133(+) HCC cells displayed more stem cell-like properties, tumor spheroid-forming ability, chemoresistance, migration ability, and tumorigenic capacity than CD133(-) HCC cells...
December 27, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28034804/whole-body-clonality-analysis-in-an-aggressive-stlv-1-associated-leukemia-atll-reveals-an-unexpected-clonal-complexity
#18
Jocelyn Turpin, Sandrine Alais, Ambroise Marçais, Julie Bruneau, Anat Melamed, Nicolas Gadot, Yuetsu Tanaka, Olivier Hermine, Sandrine Melot, Romain Lacoste, Charles R Bangham, Renaud Mahieux
HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 10(10)/L, lymphocytes with abnormal nuclear morphology, and pulmonary and skin lesions. The animal was treated with a combination of AZT and alpha interferon. Proviral load (PVL) was measured every week. Because the disease continued to progress, the animal was euthanized. Abnormal infiltrates of CD3(+)CD25(+) lymphocytes and Tax-positive cells were found by histological analyses in both lymphoid and non-lymphoid organs...
December 26, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28025102/somatostatin-receptor-targeted-liposomes-with-diacerein-inhibit-il-6-for-breast-cancer-therapy
#19
Rashmi Bharti, Goutam Dey, Indranil Banerjee, Kaushik Kumar Dey, Sheetal Parida, B N Prashanth Kumar, Chandan Kanta Das, Ipsita Pal, Manabendra Mukherjee, Mridula Misra, Anjan K Pradhan, Luni Emdad, Swadesh K Das, Paul B Fisher, Mahitosh Mandal
Selective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this study, a synthetic somatostatin analogue (SST) was used as SSTR2 targeting agent and Diacerein was employed as therapeutic molecule. Diacerein loaded liposomes (DNL) were prepared and they were further decorated with the synthetic and stable analogue of somatostatin (SST-DNL)...
December 24, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28025101/soluble-guanylate-cyclase-stimulators-increase-sensitivity-to-cisplatin-in-head-and-neck-squamous-cell-carcinoma-cells
#20
Traci R Tuttle, Vinita Takiar, Bhavna Kumar, Pawan Kumar, Nira Ben-Jonathan
Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease. Cisplatin is the most common chemotherapeutic drug in the treatment of HNSCC, but intrinsic and acquired resistance are frequent, and severe side effects occur at high doses. The second messenger cyclic GMP (cGMP) is produced by soluble guanylate cyclase (sGC). We previously reported that activation of the cGMP signaling cascade caused apoptosis in HNSCC cells, while others found that this pathway enhances cisplatin efficacy in some cell types...
December 23, 2016: Cancer Letters
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