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Drug and Alcohol Dependence

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https://www.readbyqxmd.com/read/27923198/detoxification-with-titration-and-tapering-in-gamma-hydroxybutyrate-ghb-dependent-patients-the-dutch-ghb-monitor-project
#1
Boukje A G Dijkstra, Rama Kamal, Martijn S van Noorden, Hein de Haan, Anton J M Loonen, Cor A J De Jong
BACKGROUND AND AIMS: Gamma-hydroxybutyrate (GHB) detoxification procedures have been insufficiently studied for effectiveness and safety. Based on case reports, benzodiazepines are generally regarded as first-choice agents in GHB detoxification. Detoxification by titration and tapering (DeTiTap) with pharmaceutical GHB in an open-label consecutive case series of 23 GHB-dependent patients showed to be feasible, effective and safe. This study further explored the feasibility, effectiveness and safety of this detoxification procedure in a large group of patients...
November 21, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27918951/subjective-alcohol-responses-in-a-cross-sectional-field-based-study-of-adolescents-and-young-adults-effects-of-age-drinking-level-and-dependence-consequences
#2
Hayley Treloar, Mark A Celio, Stephen A Lisman, Robert Miranda, Linda P Spear
BACKGROUND: Adolescents are physically, cognitively, socially, and emotionally different than adults in ways that may partially explain why alcohol misuse typically develops during this period. Ample animal-science evidence and nascent ecological evidence points toward developmentally limited differences in sensitivity to alcohol's stimulatory and sedative effects. Field-based research methods were used to test for such age-related differences in a sample of adolescents through young adults...
November 16, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27918950/association-between-breath-alcohol-concentration-and-waterpipe-lounge-patrons-carbon-monoxide-exposure-a-field-investigation
#3
Eleanor L Leavens, Emma I Brett, Summer Frank, Raees A Shaikh, Thad R Leffingwell, Julie M Croff, Theodore L Wagener
BACKGROUND AND AIMS: Concurrent alcohol use and waterpipe (WP) smoking is common among young adults. WP smokers are more than twice as likely to use alcohol as non-users and frequently consume alcohol immediately before and during a WP smoking session. It is unclear what impact alcohol has on WP smoking patterns and resultant exposure to tobacco-related toxicants. The current research aimed to understand the association between alcohol consumption and WP smoke exposure among WP lounge patrons...
November 16, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27907862/alteration-of-%C3%AE-n-acetylgalactosaminidase-nagalase-concentration-in-alcohol-dependent-individuals-without-liver-disease-during-the-detoxification-therapy
#4
Margarita Zoga, Thomas Nikou, Anastasios Ioannidis, Elias Tzavellas, Thomas Paparrigopoulos, Konstantinos Th Lambrokostopoulos, Vassilis G Vasdekis, Maria Magana, Stylianos Chatzipanagiotou
BACKGROUND: The present study aimed to investigate for the first time, the alteration of α-N-acetylgalactosaminidase (nagalase) concentration in alcohol-dependent individuals without liver disease, before, during and at the end of the detoxification therapy. METHODS: Forty-eight alcohol-dependent individuals without liver disease who were admitted for alcohol detoxification, and eighty-four healthy controls participated in this study. Patients' blood was obtained upon admission, two weeks later and after the completion of the detoxification period (4-5 weeks)...
November 16, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27894043/treatment-seeking-in-cannabis-dependence-the-role-of-social-cognition
#5
Zoe E Papinczak, Jason P Connor, Gerald F X Feeney, Ross McD Young, Matthew J Gullo
BACKGROUND AND AIMS: Relatively few cannabis dependent individuals seek treatment and little is known about the determinants of treatment seeking. Social Cognitive Theory (SCT) provides a useful framework for examining human behaviour and motivation which may be helpful in explaining treatment seeking. This study examined the differences in cannabis outcome expectancies and cannabis refusal self-efficacy between treatment seekers and non-treatment seekers with cannabis dependence. DESIGN: Non-treatment seekers were referred to an illicit drug diversion program...
November 14, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27889592/marijuana-effects-on-changes-in-brain-structure-and-cognitive-function-among-hiv-and-hiv-adults
#6
April D Thames, Taylor P Kuhn, Timothy J Williamson, Jacob D Jones, Zanjbeel Mahmood, Andrea Hammond
BACKGROUND: The current study examined the independent and interactive effects of HIV and marijuana (MJ) use on brain structure and cognitive function among a sample of HIV-positive (HIV+) and HIV-negative (HIV-) individuals. METHODS: Participants (HIV+, n=48; HIV-, n=29) individuals underwent cognitive testing, questionnaires about substance use, and brain MRI. The HIV+ group was clinically stable based upon current plasma CD4 count, 50% had undetectable viral load (i...
November 14, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27889593/prevalence-and-patterns-of-cigarette-smoking-among-patients-co-infected-with-human-immunodeficiency-virus-and-tuberculosis-in-tanzania
#7
Ramadhani Stephano Mwiru, Tumaini Joseph Nagu, Pamela Kaduri, Ferdinand Mugusi, Wafaie Fawzi
INTRODUCTION: Cigarette smoking is one of the major risk factors for non-AIDS related morbidities and is highly prevalent among HIV infected people. However, no reports exist from Tanzania, one of the countries highly affected by the HIV pandemic and one of Africa's biggest tobacco producer. METHODS: We examined the patterns and prevalence of cigarette smoking among HIV and TB co-infected adult patients in Dar es Salaam using a cross sectional study design. Proportions were used to describe the pattern of cigarette smoking...
November 12, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27875801/the-widening-gender-gap-in-marijuana-use-prevalence-in-the-u-s-during-a-period-of-economic-change-2002-2014
#8
Hannah Carliner, Pia M Mauro, Qiana L Brown, Dvora Shmulewitz, Reanne Rahim-Juwel, Aaron L Sarvet, Melanie M Wall, Silvia S Martins, Geoffrey Carliner, Deborah S Hasin
AIM: Concurrently with increasingly permissive attitudes towards marijuana use and its legalization, the prevalence of marijuana use has increased in recent years in the U.S. Substance use is generally more prevalent in men than women, although for alcohol, the gender gap is narrowing. However, information is lacking on whether time trends in marijuana use differ by gender, or whether socioeconomic status in the context of the Great Recession may affect these changes. METHODS: Using repeated cross-sectional data from the National Survey on Drug Use and Health (2002-2014), we examined changes over time in prevalence of past-year marijuana use by gender, and whether gender differences varied across income levels...
November 11, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27886524/effects-of-ethanol-on-cocaine-self-administration-in-monkeys-responding-under-a-second-order-schedule-of-reinforcement
#9
William S John, Michael A Nader
BACKGROUND: Concurrent alcohol use among cocaine abusers is common but the behavioral variables that promote co-abuse are not well understood. The present study examined the effects of intragastric (i.g.) ethanol (EtOH) administration in monkeys responding under a schedule of cocaine reinforcement in which extensive drug seeking was maintained by conditioned stimuli. METHODS: Four adult male cynomolgus monkeys (Macaca fascicularis) were trained to respond under a second-order fixed-interval (FI) 600s (fixed-ratio (FR) 30:S) schedule of cocaine (0...
November 10, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27883946/pattern-and-risk-of-developing-alcohol-use-disorders-illegal-substance-use-and-psychiatric-disorders-after-early-onset-of-alcohol-use-results-of-the-thai-national-mental-health-survey-2013
#10
Athip Tanaree, Sawitri Assanangkornchai, Phunnapa Kittirattanapaiboon
INTRODUCTION: Although underage drinking is a global concern, little is known about the relationship between age at first drink and development of various psychiatric comorbidities. METHODS: A secondary data analysis was done among 2928 lifetime drinkers from the Thai National Mental Health Survey 2013. Age at first drink, and onset of related psychiatric outcomes were inquired. Survival analysis using Cox regression was performed to estimate the risk over time for psychiatric problems across age ranges at first drink...
November 10, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27883949/nicotine-levels-withdrawal-symptoms-and-smoking-reduction-success-in-real-world-use-a-comparison-of-cigarette-smokers-and-dual-users-of-both-cigarettes-and-e-cigarettes
#11
Douglas E Jorenby, Stevens S Smith, Michael C Fiore, Timothy B Baker
INTRODUCTION: To evaluate how experienced dual users used cigarettes and e-cigarettes in real-world use and under different levels of cigarette availability. METHODS: Dual users (cigarettes+e-cigarettes; n=74) and a smoke-only group (just cigarettes; n=74) engaged in a 26-day study with two ad lib use intervals, a week of 75% cigarette reduction and three days of 100% cigarette reduction. After a week of ad lib use of products, all participants were asked to reduce smoking by 75% (dual users were free to use their e-cigarettes as they wished), followed by another week of ad lib use...
November 9, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27875803/analysis-of-alcohol-use-disorders-from-the-nathan-kline-institute-rockland-sample-correlation-of-brain-cortical-thickness-with-neuroticism
#12
Yihong Zhao, Zhi-Liang Zheng, F Xavier Castellanos
BACKGROUND: Although differences in both neuroanatomical measures and personality traits, in particular neuroticism, have been associated with alcohol use disorders (AUD), whether lifetime AUD diagnosis alters the relationship between neuroticism and neuroanatomical structures remains to be determined. METHODS: Data from 65 patients with lifetime AUD diagnoses and 65 healthy comparisons (HC) group-matched on age, sex and race were extracted from the Nathan Kline Institute - Rockland Sample data set...
November 8, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27875800/evaluation-of-tspo-pet-imaging-a-marker-of-glial-activation-to-study-the-neuroimmune-footprints-of-morphine-exposure-and-withdrawal
#13
Sylvain Auvity, Sébastien Goutal, Benoît Thézé, Catarina Chaves, Benoît Hosten, Bertrand Kuhnast, Wadad Saba, Raphaël Boisgard, Irène Buvat, Salvatore Cisternino, Nicolas Tournier
INTRODUCTION: A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine-induced analgesia and prevent the development of tolerance and dependence. Positron emission tomography (PET) using translocator protein 18kDa (TSPO) radioligand is a clinically validated strategy for the non-invasive detection of microglial activation...
November 8, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27883948/prevalence-sociodemographic-correlates-and-dsm-5-substance-use-disorders-and-other-psychiatric-disorders-among-sexual-minorities-in-the-united-states
#14
Bradley T Kerridge, Roger P Pickering, Tulshi D Saha, W June Ruan, S Patricia Chou, Haitao Zhang, Jeesun Jung, Deborah S Hasin
PURPOSE: The purpose of this study was to present current nationally representative data on the prevalences, sociodemographic correlates and risk of DSM-5 substance use disorders and other psychiatric disorders among sexual minorities (SMs) relative to heterosexuals, and among SMs by gender. METHODS: Data were derived from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III. RESULTS: In the general noninstitutionalized population, 1...
November 7, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27865152/psychoactive-medications-and-disengagement-from-office-based-opioid-treatment-obot-with-buprenorphine
#15
Zoe M Weinstein, Debbie M Cheng, Emily Quinn, David Hui, Hyunjoong Kim, Gabriela Gryczynski, Jeffrey H Samet
BACKGROUND: The prevalence of psychoactive medications (PAMs) use in patients enrolled in Office Based Opioid Treatment (OBOT) and its association with engagement in this care is largely unknown. OBJECTIVE: To describe the use of PAMs, including those medications with emerging evidence of misuse ("emerging PAMs" - gabapentin, clonidine and promethazine) among patients on buprenorphine, and its association with disengagement from OBOT. METHODS: This is a retrospective cohort study of adults on buprenorphine from January 2002 to February 2014...
November 5, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27883947/social-cognitive-predictors-of-treatment-outcome-in-cannabis-dependence
#16
Matthew J Gullo, Marya Matveeva, Gerald F X Feeney, Ross McD Young, Jason P Connor
BACKGROUND: Drug-related outcomes expectancies and refusal self-efficacy are core components of Social Cognitive Theory. Both predict treatment outcome in alcohol use disorders. Few studies have reported expectancies and refusal self-efficacy in cannabis dependence. None have examined both, although both constructs are key targets in Cognitive-Behavioural Therapy (CBT). This study tests the predictive role of expectancies and refusal self-efficacy in treatment outcome for cannabis dependence...
November 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27870987/single-arm-trial-of-the-second-version-of-an-acceptance-commitment-therapy-smartphone-application-for-smoking-cessation
#17
Jonathan B Bricker, Wade Copeland, Kristin E Mull, Emily Y Zeng, Noreen L Watson, Katrina J Akioka, Jaimee L Heffner
BACKGROUND: The first randomized trial of a smartphone application (app) for adult smoking cessation (SmartQuit 1.0) revealed key features that predict cessation. These findings guided the revision of this Acceptance & Commitment Therapy (ACT)-based application (SmartQuit 2.0), which was primarily tested to examine participant receptivity, short-term cessation and reduction, and the relationship between program completion, smoking cessation and reduction. Secondarily, outcomes were descriptively compared with the SmartQuit1...
November 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27865151/effects-of-the-benzodiazepine-gabaa-%C3%AE-1-preferring-antagonist-3-isopropoxy-%C3%AE-carboline-hydrochloride-3-isopbc-on-alcohol-seeking-and-self-administration-in-baboons
#18
August F Holtyn, V V N Phani Babu Tiruveedhula, Michael Rajesh Stephen, James M Cook, Elise M Weerts
BACKGROUND: The major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), modulates many of the behavioral effects of alcohol, including sedation, tolerance, and withdrawal. The α1 subunit of the benzodiazepine GABAA receptor is the most widely expressed alpha subunit in the brain, and has been implicated in the reinforcing- and abuse-related effects of alcohol. The aim of the present study was to examine whether treatment with a benzodiazepine GABAA α1-preferring ligand, 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC), selectively decreases alcohol seeking and consumption...
November 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27855317/the-design-of-medical-marijuana-laws-and-adolescent-use-and-heavy-use-of-marijuana-analysis-of-45-states-from-1991-to-2011
#19
Julie Johnson, Dominic Hodgkin, Sion Kim Harris
OBJECTIVES: To assess the association between U.S. state medical marijuana laws (MML), the most liberal category of marijuana policies before legalization, their specific provisions, and adolescent past-30-day use and heavy marijuana use. METHODS: This quasi-experimental study used state Youth Risk Behavior Survey (YRBS) data collected during 1991-2011 from 45 states (N=715,014) to examine MML effects, taking advantage of heterogeneity across states in MML status and design...
November 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27889594/racial-ethnic-differences-in-30-year-trajectories-of-heavy-drinking-in-a-nationally-representative-u-s-sample
#20
Nina Mulia, Katherine J Karriker-Jaffe, Jane Witbrodt, Jason Bond, Edwina Williams, Sarah E Zemore
BACKGROUND: Racial/ethnic minorities bear a disproportionate burden of alcohol-related problems in the U.S. It is unknown whether this reflects harmful patterns of lifecourse heavy drinking. Prior research shows little support for the latter but has been limited to young samples. We examine racial/ethnic differences in heavy drinking trajectories from ages 21 to 51. METHODS: Data on heavy drinking (6+ drinks/occasion) are from the 1979 National Longitudinal Survey of Youth (N=9468), collected between 1982 and 2012...
November 3, 2016: Drug and Alcohol Dependence
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