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Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Natalie Moll, Beat Lutz, Laura Bindila, Inga Zerr, Matthias Schmitz, Kaj Blennow, Henrik Zetterberg, Dieter Haffner, Maren Leifheit-Nestler, Cagakan Ozbalci, Christoph Janke, Manfred Thiel, Alexander Sartorius
BACKGROUND: No candidate biomarkers based on cerebrospinal fluid (CSF) have been identified as prognostic factors in patients with major depression treated with electroconvulsive therapy (ECT), yet. METHOD: Following different underlying hypotheses, we analysed baseline CSF levels of markers of neurodegeneration (tau proteins, β-amyloids and neurogranin), elements of the innate immune system (interleukin [IL]-6, neopterin, soluble CD14, soluble CD163, migration inhibitory factor and monocyte chemotactic protein 1), endocannabinoids, sphingolipids and Klotho before ECT in patients with depression (n = 12) to identify possible correlations with the clinical antidepressant response to ECT...
August 17, 2018: Neuropsychobiology
Vincenzo De Luca, Gianfranco Spalletta, Renan P Souza, Ariel Graff, Luciana Bastos-Rodrigues, Maria Aparecida Camargos Bicalho
BACKGROUND/OBJECTIVES: This study aims to investigate the role of apolipoprotein E (APOE) e4 influencing the age at onset (AAO) of Alzheimer's disease (AD). In AD, the AAO of dementia varies from 40 to 90 years. Usually, AD patients who develop symptoms before the age of 65 are considered as early-onset AD (EOAD). However, considering the heterogeneity of the AD onset, the definition of late-onset AD (LOAD) cannot rely on an arbitrary cut-off. Thus, we aim to validate the anticipation effect of the APOE e4 allele in LOAD...
August 15, 2018: Neuropsychobiology
Penelope M Sheehan, Chad Bousman, Angela Komiti, Fiona Judd, Louise Newman, Bruce Tonge, David Castle, Ian Everall
INTRODUCTION: The aim of this study was to expand on this field of work by examining, within a cohort of pregnant women with diagnosed clinical anxiety, the mRNA expression of a panel of genes associated with the cortisol pathway and comparing them to controls. METHODS: Placental samples were obtained from 24 pregnant women, 12 with a diagnosed anxiety disorder and 12 with no psychiatric history, within 30 min of delivery. Differential expression analysis of 85 genes known to be involved in glucocorticoid synthesis, metabolism or signalling was conducted for the: (1) full sample, (2) those at term without labour (5 cases, 7 controls) and (3) those at term with labour (7 cases, 5 controls)...
August 15, 2018: Neuropsychobiology
Maurizio Pompili, Luana Lionetto, Martina Curto, Alberto Forte, Denise Erbuto, Franco Montebovi, Maria Elena Seretti, Isabella Berardelli, Gianluca Serafini, Marco Innamorati, Mario Amore, Ross J Baldessarini, Paolo Girardi, Maurizio Simmaco
BACKGROUND: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects of inflammatory peptides which activate indoleamine-2,3-dioxygenase. However, these findings have been inconsistent and require replication...
August 15, 2018: Neuropsychobiology
Eiji Kirino, Shoji Tanaka, Mayuko Fukuta, Rie Inami, Reiichi Inoue, Shigeki Aoki
BACKGROUND: Aberrant functional connectivity (FC) is increasingly implicated in the clinical phenomenology of schizophrenia. This study focused on the FC of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations. METHODS: We used simultaneous resting-state functional magnetic resonance imaging (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia...
July 26, 2018: Neuropsychobiology
Berend Malchow, Katrin Levold, Marcin Labusga, Katriona Keller-Varady, Thomas Schneider-Axmann, Thomas Wobrock, Andrea Schmitt, Peter Falkai, Alkomiet Hasan
BACKGROUND: Aerobic endurance training has been discussed to induce brain plasticity and improve cognitive functions in healthy subjects and patients with neuropsychiatric disorders. For schizophrenia, a motor cortical inhibitory deficit has been established as one aspect of impaired plasticity, especially involving impairments in GABAergic interneuron networks, but the possibility to restore these deficits via exercise-induced plasticity has not been evaluated yet. METHODS: 17 schizophrenia patients and 16 matched healthy controls underwent 3 months of aerobic endurance training (30 min, 3 times a week) on bicycle ergometers...
July 12, 2018: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2018: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2017: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
2017: Neuropsychobiology
Stefano Porcelli, Agnese Marsano, Elisabetta Caletti, Michela Sala, Vera Abbiati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Gian Mario Mandolini, Alessandro Pigoni, Riccardo Augusto Paoli, Sara Piccin, Matteo Lazzaretti, Dora Fabbro, Giuseppe Damante, Carolina Bonivento, Clarissa Ferrari, Roberta Rossi, Laura Pedrini, Alessandro Serretti, Paolo Brambilla
BACKGROUND: Bipolar disorder (BD) has been associated with temperamental and personality traits, although the relationship is still to be fully elucidated. Several studies investigated the genetic basis of temperament and character, identifying catechol-O-methyltransferase (COMT), brain derived neurotrophic factor (BDNF), and serotonin transporter (5-HTT) gene variants as strong candidates. METHODS: In the GECO-BIP study, 125 BD patients and 173 HC were recruited...
2017: Neuropsychobiology
Linda van Diermen, Didier Schrijvers, Olivia Cools, Tom K Birkenhäger, Erik Fransen, Bernard G C Sabbe
BACKGROUND: Retardation and agitation are symptoms of major depressive disorder (MDD), and their presence could play a role in determining clinically meaningful depressive subtypes such as nonmelancholic depression (NMD) and melancholic depression (MD). In this project, we explored whether three depression subgroups (NMD, MD with psychotic symptoms, and MD without psychotic symptoms) could be distinguished based on objective measures of psychomotor functioning. METHODS: Sixty-nine patients with MDD underwent extensive clinical and psychomotor testing prior to treatment with electroconvulsive therapy...
2017: Neuropsychobiology
Alma Delia Genis-Mendoza, María Lilia López-Narvaez, Carlos Alfonso Tovilla-Zárate, Emmanuel Sarmiento, Adriana Chavez, Jose Jaime Martinez-Magaña, Thelma Beatriz González-Castro, Yazmín Hernández-Díaz, Isela Esther Juárez-Rojop, Ángela Ávila-Fernández, Humberto Nicolini
BACKGROUND: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. METHODS: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models...
2017: Neuropsychobiology
Goyo Nagai, Kazuo Mihara, Shoko Kagawa, Akifumi Nakamura, Takeshi Suzuki, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: The present study prospectively examined whether or not a partial response at week 4 predicts subsequent response at week 8 during lamotrigine augmentation therapy in 51 (16 males and 35 females) inpatients with treatment-resistant depressive disorder using an open-study design. METHODS: The subjects were 51 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
2017: Neuropsychobiology
Amit Shalev, Fortunato Benarroch, Tanya Goltser-Dubner, Laura Canetti, Chen Saloner, Asael Roichman, Haim Cohen, Esti Galili-Weisstub, Ronen Segman
BACKGROUND AND AIM: Long-term immune alterations have been proposed to play a mechanistic role in posttraumatic stress disorder (PTSD) as well as in its associated increase in medical morbidity and mortality. Better characterization of altered immune function may help identify diagnostic and prognostic biomarkers and potentially targets for preventive intervention. METHODS: As part of an ongoing study, we conducted a preliminary case-control comparison of resting immune inflammatory profiles between terror victims treated in childhood at the emergency department over the previous decade, who developed chronic PTSD upon long-term follow-up, and healthy controls...
2017: Neuropsychobiology
Vera E Golimbet, Zhanna V Garakh, Yuliya Zaytseva, Margarita V Alfimova, Tatyana V Lezheiko, Nikolay V Kondratiev, Alexander B Shmukler, Isaac Ya Gurovich, Valeria B Strelets
BACKGROUND: Visual word recognition is one of the central topics in cognitive psychology and cognitive neuroscience. Genetic factors are known to contribute to the visual word recognition, but no genes associated with this process have been identified so far. We studied the impact of the DRD2 C957T polymorphism on the efficiency of visual word recognition by measuring its neuronal correlates and behavioral parameters. Early (~200 ms) components of event-related potentials (ERP) were recorded during a lexical decision task...
2017: Neuropsychobiology
Athanasia Papadopoulou, Athanasios Douzenis, Christos Christodoulou, Rossetos Gournellis, Charalabos Papageorgiou, Manolis Markianos
OBJECTIVE: There is evidence that suicidal behavior, among others, is an abnormal response to stress caused by a dysfunction in the activity of hypothalamus-pituitary-adrenal axis, and that cortisol levels are low in a considerable number of people attempting suicide. In this study, we aimed to search for associations of plasma cortisol levels with the clinical characteristics of a group of psychiatric suicide attempters. METHOD: The cortisol was measured in the morning in 200 psychiatric patients hospitalized after a suicide attempt, with diagnoses of major depressive disorder, bipolar disorder, psychosis, and personality/adjustment disorder, and compared to the levels of 138 healthy controls...
2017: Neuropsychobiology
Julius Burkauskas, Adomas Bunevičius, Julija Brožaitienė, Julius Neverauskas, Naomi A Fineberg, David Wellsted, Robertas Bunevičius, Narseta Mickuvienė
OBJECTIVE: Fatigue and reduced exercise capacity are common concomitants of coronary artery disease (CAD). They are known to be associated with the deterioration in mental health, including emotional and cognitive status. However, the precise nature of the inter-relationship is poorly understood. The aim of this study was to investigate the relationship between fatigue and exercise capacity on the one hand and changes in cognitive functioning on the other, to generate new heuristics for clinical management and outcome prediction of CAD...
2017: Neuropsychobiology
Annemarie Goltz, Deborah Janowitz, Anke Hannemann, Matthias Nauck, Johanna Hoffmann, Tom Seyfart, Henry Völzke, Jan Terock, Hans Jörgen Grabe
BACKGROUND: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. METHODS: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926)...
2017: Neuropsychobiology
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with trichotillomania (both are OC-related disorders). The role of inflammation in the pathophysiology of trichotillomania has garnered little research to date. METHODS: Individuals with trichotillomania provided saliva sample for analysis of inflammatory cytokines...
2017: Neuropsychobiology
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