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Neuropsychobiology

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https://www.readbyqxmd.com/read/29151101/psychoacoustics-and-neurophysiological-alterations-after-30-36-hours-of-sleep-deprivation
#1
Adrián Poblano, Sergio Díaz-Leines, Olga Gama-Moreno, Blanca Flores-Avalos
BACKGROUND AND AIM: Sleep deprivation (SD) may result in perceptual and cognitive alterations in healthy subjects. Our objective was to compare whether psychoacoustics and neurophysiological variables in healthy subjects were altered after SD of 30-36 h. METHOD: We examined 22 subjects by means of several psychoacoustics tests, P300 and mismatch negativity (MMN) recordings, and brainstem auditory evoked potentials (BAEP) before and after 30-36 h of SD. RESULTS: In the psychoacoustics tests, we found that after SD, difficulties were experienced by the left ear in the discrimination of words in noise and by the right ear in music discrimination...
November 18, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29131015/therapeutic-response-to-paroxetine-in-major-depressive-disorder-predicted-by-dna-methylation
#2
Naohiro Takeuchi, Shinpei Nonen, Masaki Kato, Masataka Wakeno, Yoshiteru Takekita, Toshihiko Kinoshita, Fumihiko Kugawa
BACKGROUND: Antidepressants have variable therapeutic effects, depending on genetic and environmental factors. Approximately 30% of major depressive disorder (MDD) patients do not respond significantly to antidepressants such as paroxetine, a selective serotonin reuptake inhibitor (SSRI). However, the biological mechanisms behind this phenomenon are mostly unknown. Here, we examined the role of patients' epigenetic background in SSRI efficacy. METHODS: Genome-wide DNA methylation analysis of the peripheral blood of Japanese MDD patients was performed by using the Infinium HumanMethylation450 BeadChip...
November 4, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29065422/acute-phencyclidine-alters-neural-oscillations-evoked-by-tones-in-the-auditory-cortex-of-rats
#3
Ashley M Schnakenberg Martin, Brian F OʼDonnell, James B Millward, Jenifer L Vohs, Emma Leishman, Amanda R Bolbecker, Olga Rass, Sandra L Morzorati
BACKGROUND/AIMS: The onset response to a single tone as measured by electroencephalography (EEG) is diminished in power and synchrony in schizophrenia. Because neural synchrony, particularly at gamma frequencies (30-80 Hz), is hypothesized to be supported by the N-methyl-D-aspartate receptor (NMDAr) system, we tested whether phencyclidine (PCP), an NMDAr antagonist, produced similar deficits to tone stimuli in rats. METHODS: Experiment 1 tested the effect of a PCP dose (1...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29065417/comparisons-between-psychiatric-symptoms-of-patients-with-anti-nmdar-encephalitis-and-new-onset-psychiatric-patients
#4
Jinxiang Wang, Bo Zhang, Manxue Zhang, Junming Chen, Hong Deng, Qiang Wang, Xueli Sun
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a potentially lethal autoimmune disease. Early diagnosis and immunotherapy can improve prognosis; however, early prominent psychiatric symptoms have led to misdiagnosis in numerous cases, delaying diagnosis and treatment. This study aimed to explore the clinical features and psychiatric symptoms of anti-NMDAR encephalitis and the association between antibody titers and psychiatric symptoms. METHODS: In this retrospective study, 43 patients with anti-NMDAR encephalitis and 70 new-onset psychiatric patients were enrolled...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29065400/dose-dependent-effects-of-binge-like-methamphetamine-dosing-on-dopamine-and-neurotrophin-levels-in-rat-brain
#5
Andreia Moreira da Silva Santos, John P Kelly, Karen M Doyle
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29035887/valeriana-officinalis-root-extract-modulates-cortical-excitatory-circuits-in-humans
#6
Ludovico Mineo, Carmen Concerto, Dhaval Patel, Tyrone Mayorga, Michael Paula, Eileen Chusid, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Valeriana officinalis extract (VE) is a popular herbal medicine used for the treatment of anxiety and sleep disorders. Although the anxiolytic and sedative effects are mainly attributed to the modulation of GABA-ergic transmission, the mechanism of action has not been fully investigated in humans. Noninvasive brain stimulation protocols can be used to elucidate the mechanisms of action of psychoactive substances at the cortical level in humans. In this study, we investigated the effects of a single dose of VE on cortical excitability as assessed with transcranial magnetic stimulation (TMS)...
October 17, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29032375/erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28848102/plasma-bdnf-level-in-major-depression-biomarker-of-the-val66met-bdnf-polymorphism-and-of-the-clinical-course-in-met-carrier-patients
#8
Romain Colle, Séverine Trabado, Denis J David, Sylvie Brailly-Tabard, Patrick Hardy, Bruno Falissard, Bruno Fève, Laurent Becquemont, Céline Verstuyft, Emmanuelle Corruble
AIMS: Despite the involvement of the brain-derived neurotrophic factor (BDNF) in the physiopathology of major depressive disorder (MDD), the coherence between the components of the BDNF pathway and their link with the clinical features of MDD are insufficiently studied. We aimed to assess in Caucasian depressed patients the impact of the BDNF Val66Met polymorphism on plasma BDNF levels taking into account the clinical characteristics of MDD. METHODS: A total of 328 Caucasian adult MDD patients with a current major depressive episode (MDE) were assessed for the BDNF Val66Met polymorphism, plasma BDNF levels and clinical characteristics of the MDD...
August 23, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28803247/potential-gender-related-aging-processes-occur-earlier-and-faster-in-the-vermis-of-patients-with-bipolar-disorder-an-mri-study
#9
Marta Serati, Giuseppe Delvecchio, Giulia Orsenigo, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, Alfredo Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. METHODS: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1...
August 12, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28793304/frontal-cortex-myo-inositol-is-associated-with-sleep-and-depression-in-adolescents-a-proton-magnetic-resonance-spectroscopy-study
#10
Anna S Urrila, Antti Hakkarainen, Anu Castaneda, Tiina Paunio, Mauri Marttunen, Nina Lundbom
AIM: This study used proton magnetic resonance spectroscopy (1H MRS) to evaluate the neurochemistry of the frontal cortex in adolescents with symptoms of sleep and depression. METHODS: Nineteen non-medicated adolescent boys (mean age 16.0 years; 9 clinical cases with depression/sleep symptoms and 10 healthy controls) underwent 1H MRS at 3 T. MR spectra were acquired from the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex, and frontal white matter...
August 10, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28750407/in-individuals-following-aneurysmal-subarachnoid-haemorrhage-hair-cortisol-concentrations-are-higher-and-more-strongly-associated-with-psychological-functioning-and-sleep-complaints-than-in-healthy-controls
#11
Flora Colledge, Serge Brand, Stefan Zimmerer, Uwe Pühse, Edith Holsboer-Trachsler, Markus Gerber
BACKGROUND: Following an aneurysmal subarachnoid haemorrhage (aSAH), many patients report persistent deficits in psychological functioning, characterised by high levels of stress and symptoms of depression, low life satisfaction, along with poor sleep. Such deficits have been associated with altered saliva and serum cortisol levels due to a dysregulation of hypothalamic-pituitary-adrenal axis activity (HPA-AA). However, hair cortisol concentrations (HCCs) have not been assessed in this population, although this method allows a long-term insight into cortisol values...
July 28, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28700991/strain-differences-and-effects-of-environmental-manipulation-on-astrocytes-glial-fibrillary-acidic-protein-glucocorticoid-receptor-and-microglia-iba1-immunoreactivity-between-wistar-kyoto-and-wistar-females
#12
Guergana R Mileva, Carinna Moyes, Shaezeen Syed, Catherine Bielajew
BACKGROUND: Depression is often associated with an increase in hypothalamic-pituitary-adrenal (HPA) axis reactivity and immune response. To investigate this relationship, we examined the consequences of environmental manipulation on the neural correlates of the HPA axis and immune response in an animal model of depression, the Wistar-Kyoto (WKY) rat. Additionally, female animals are often overlooked in preclinical research because of the hormone fluctuations inherent in the estrous cycle...
July 13, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28178693/abstracts-of-award-winning-posters-16th-international-forum-on-mood-and-anxiety-disorders-rome-december-8-10-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28637048/use-of-light-therapy-by-office-based-physicians
#14
Edda Winkler-Pjrek, Marie Spies, Pia Baldinger-Melich, Lisa Perkmann, Siegfried Kasper, Dietmar Winkler
BACKGROUND: Light therapy (LT) is a non-pharmacological biological treatment that has been used in psychiatry since the 1980s. Previous research has investigated the usage of LT in hospitals. The aim of this study was to examine the pattern of use of LT by office-based physicians. METHODS: A questionnaire was sent by mail to 400 randomly selected doctors in Austria. We made sure that the sample was equally representative of general practitioners (GPs) and psychiatrists, public health service doctors and private doctors, physicians in cities and in the country as well as male and female doctors...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637044/depressed-patients-hospitalized-in-southeast-facing-rooms-are-discharged-earlier-than-patients-in-northwest-facing-rooms
#15
Krzysztof Gbyl, Helle Østergaard Madsen, Signe Dunker Svendsen, Paul Michael Petersen, Ida Hageman, Carlo Volf, Klaus Martiny
BACKGROUND AND AIM: Improvement in patients admitted to inpatient wards with severe depression is slow, and such patients are often discharged with residual symptoms which put them at risk for relapse. New treatments that can speed up recovery are highly desired. This naturalistic follow-up study in a specialized affective disorders unit investigated the impact of daylight on the length of hospital stay and improvement of depression. METHODS: For a period of 1 year, we collected data on sociodemographics, length of stay, vitamin D, and depression severity for patients in an inpatient affective disorders unit...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637043/editorial
#16
Anna Wirz-Justice, Mirjam Münch
No abstract text is available yet for this article.
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637035/is-there-a-relationship-between-vegetarianism-and-seasonal-affective-disorder-a-pilot-study
#17
Alie N R Meesters, Mirkka Maukonen, Timo Partonen, Satu Männistö, Marijke C M Gordijn, Ybe Meesters
BACKGROUND AND AIM: Seasonal patterns of food intake are found in healthy individuals and particularly in patients with seasonal affective disorder (SAD). One nutritional choice is a vegetarian diet. METHODS: In a Finnish population study, FINRISK 2012, information about diet and SAD was collected. In a Dutch outpatient clinic, SAD patients were asked if they were vegetarian. RESULTS: The percentage of SAD patients among Finnish vegetarians was 4 times higher than in the normal population...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637032/investigation-of-an-immediate-effect-of-bright-light-on-oxygen-consumption-heart-rate-cortisol-and-%C3%AE-amylase-in-seasonal-affective-disorder-subjects-and-healthy-controls
#18
Iana A Ivanova, Konstantin V Danilenko, Lyubomir I Aftanas
BACKGROUND: Body (fat) mass has been shown to decrease following bright light treatment for overweight women, irrespective of their seasonal (light) dependence. It is not known if this is due to an (immediate) increase of metabolism. METHODS: Ten women with seasonal affective disorder (SAD) and 10 non-SAD women matched by age, body mass index, and menopausal status participated in a laboratory study in the morning, twice within 1-5 days. During one session, bright light (4,300 lx) was presented for 30 min, and during the other session, red light (250 lx "placebo") was used...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637029/blue-enriched-morning-light-as-a-countermeasure-to-light-at-the-wrong-time-effects-on-cognition-sleepiness-sleep-and-circadian-phase
#19
Mirjam Münch, Claudia Nowozin, Johannes Regente, Frederik Bes, Jan De Zeeuw, Sven Hädel, Amely Wahnschaffe, Dieter Kunz
Light during the day and darkness at night are crucial factors for proper entrainment of the human circadian system to the solar 24-h day. However, modern life and work styles have led to much more time spent indoors, often with lower daytime and higher evening/nighttime light intensity from electrical lighting than outdoors. Whether this has long-term consequences for human health is being currently investigated. We tested if bright blue-enriched morning light over several days could counteract the detrimental effects of inadequate daytime and evening lighting...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/28637028/maximizing-outcome-in-light-treatment-patient-behavior-as-the-light-treatment-delivery-system
#20
Michael A Young
The effectiveness of light treatment depends on the treatment being properly received by the patient. Examination of the typical light treatment prescription shows that delivery of each component of the prescription consists of a behavior on the part of the patient. Light treatment delivery, and thus light treatment effectiveness, can be maximized by conceptualizing the treatment as a behavior change in the patient and by the application of well-established behavior change techniques.
2016: Neuropsychobiology
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