Read by QxMD icon Read


Berend Malchow, Katrin Levold, Marcin Labusga, Katriona Keller-Varady, Thomas Schneider-Axmann, Thomas Wobrock, Andrea Schmitt, Peter Falkai, Alkomiet Hasan
BACKGROUND: Aerobic endurance training has been discussed to induce brain plasticity and improve cognitive functions in healthy subjects and patients with neuropsychiatric disorders. For schizophrenia, a motor cortical inhibitory deficit has been established as one aspect of impaired plasticity, especially involving impairments in GABAergic interneuron networks, but the possibility to restore these deficits via exercise-induced plasticity has not been evaluated yet. METHODS: 17 schizophrenia patients and 16 matched healthy controls underwent 3 months of aerobic endurance training (30 min, 3 times a week) on bicycle ergometers...
July 12, 2018: Neuropsychobiology
Linda van Diermen, Didier Schrijvers, Olivia Cools, Tom K Birkenhäger, Erik Fransen, Bernard G C Sabbe
BACKGROUND: Retardation and agitation are symptoms of major depressive disorder (MDD), and their presence could play a role in determining clinically meaningful depressive subtypes such as nonmelancholic depression (NMD) and melancholic depression (MD). In this project, we explored whether three depression subgroups (NMD, MD with psychotic symptoms, and MD without psychotic symptoms) could be distinguished based on objective measures of psychomotor functioning. METHODS: Sixty-nine patients with MDD underwent extensive clinical and psychomotor testing prior to treatment with electroconvulsive therapy...
July 4, 2018: Neuropsychobiology
Alma Delia Genis-Mendoza, María Lilia López-Narvaez, Carlos Alfonso Tovilla-Zárate, Emmanuel Sarmiento, Adriana Chavez, Jose Jaime Martinez-Magaña, Thelma Beatriz González-Castro, Yazmín Hernández-Díaz, Isela Esther Juárez-Rojop, Ángela Ávila-Fernández, Humberto Nicolini
BACKGROUND: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. METHODS: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models...
July 2, 2018: Neuropsychobiology
Goyo Nagai, Kazuo Mihara, Shoko Kagawa, Akifumi Nakamura, Takeshi Suzuki, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: The present study prospectively examined whether or not a partial response at week 4 predicts subsequent response at week 8 during lamotrigine augmentation therapy in 51 (16 males and 35 females) inpatients with treatment-resistant depressive disorder using an open-study design. METHODS: The subjects were 51 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
June 29, 2018: Neuropsychobiology
Amit Shalev, Fortunato Benarroch, Tanya Goltser-Dubner, Laura Canetti, Chen Saloner, Asael Roichman, Haim Cohen, Esti Galili-Weisstub, Ronen Segman
BACKGROUND AND AIM: Long-term immune alterations have been proposed to play a mechanistic role in posttraumatic stress disorder (PTSD) as well as in its associated increase in medical morbidity and mortality. Better characterization of altered immune function may help identify diagnostic and prognostic biomarkers and potentially targets for preventive intervention. METHODS: As part of an ongoing study, we conducted a preliminary case-control comparison of resting immune inflammatory profiles between terror victims treated in childhood at the emergency department over the previous decade, who developed chronic PTSD upon long-term follow-up, and healthy controls...
June 27, 2018: Neuropsychobiology
Vera E Golimbet, Zhanna V Garakh, Yuliya Zaytseva, Margarita V Alfimova, Tatyana V Lezheiko, Nikolay V Kondratiev, Alexander B Shmukler, Isaac Ya Gurovich, Valeria B Strelets
BACKGROUND: Visual word recognition is one of the central topics in cognitive psychology and cognitive neuroscience. Genetic factors are known to contribute to the visual word recognition, but no genes associated with this process have been identified so far. We studied the impact of the DRD2 C957T polymorphism on the efficiency of visual word recognition by measuring its neuronal correlates and behavioral parameters. Early (~200 ms) components of event-related potentials (ERP) were recorded during a lexical decision task...
June 26, 2018: Neuropsychobiology
Athanasia Papadopoulou, Athanasios Douzenis, Christos Christodoulou, Rossetos Gournellis, Charalabos Papageorgiou, Manolis Markianos
OBJECTIVE: There is evidence that suicidal behavior, among others, is an abnormal response to stress caused by a dysfunction in the activity of hypothalamus-pituitary-adrenal axis, and that cortisol levels are low in a considerable number of people attempting suicide. In this study, we aimed to search for associations of plasma cortisol levels with the clinical characteristics of a group of psychiatric suicide attempters. METHOD: The cortisol was measured in the morning in 200 psychiatric patients hospitalized after a suicide attempt, with diagnoses of major depressive disorder, bipolar disorder, psychosis, and personality/adjustment disorder, and compared to the levels of 138 healthy controls...
June 25, 2018: Neuropsychobiology
Julius Burkauskas, Adomas Bunevičius, Julija Brožaitienė, Julius Neverauskas, Naomi A Fineberg, David Wellsted, Robertas Bunevičius, Narseta Mickuvienė
OBJECTIVE: Fatigue and reduced exercise capacity are common concomitants of coronary artery disease (CAD). They are known to be associated with the deterioration in mental health, including emotional and cognitive status. However, the precise nature of the inter-relationship is poorly understood. The aim of this study was to investigate the relationship between fatigue and exercise capacity on the one hand and changes in cognitive functioning on the other, to generate new heuristics for clinical management and outcome prediction of CAD...
June 25, 2018: Neuropsychobiology
Annemarie Goltz, Deborah Janowitz, Anke Hannemann, Matthias Nauck, Johanna Hoffmann, Tom Seyfart, Henry Völzke, Jan Terock, Hans Jörgen Grabe
BACKGROUND: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. METHODS: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926)...
June 19, 2018: Neuropsychobiology
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with trichotillomania (both are OC-related disorders). The role of inflammation in the pathophysiology of trichotillomania has garnered little research to date. METHODS: Individuals with trichotillomania provided saliva sample for analysis of inflammatory cytokines...
June 19, 2018: Neuropsychobiology
Nitzan Zohar, Eldar Hochman, Nachum Katz, Amir Krivoy, Abraham Weizman, Ran Barzilay
The interplay between the immune system and behaviour is of increasing interest in psychiatry research. Specifically, accumulating data points to a link between inflammation and psychopathology, including affective symptomatology. We investigated the association between inflammation and affective polarity in psychiatric inpatients who were hospitalized due to an affective exacerbation. Data was collected retrospectively and comparisons were made between manic and depressed patients. C-reactive protein (CRP), a general laboratory marker of immune activation and inflammation, was used as a non-specific inflammatory biomarker...
June 14, 2018: Neuropsychobiology
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
Kaitlin E Bountress, Silviu-Alin Bacanu, Rachel L Tomko, Kristina J Korte, Terrell Hicks, Christina Sheerin, Mackenzie J Lind, Marisa Marraccini, Nicole Nugent, Ananda B Amstadter
OBJECTIVE: Given evidence that posttraumatic stress disorder (PTSD) is moderately heritable, a number of studies utilizing candidate gene approaches have attempted to examine the potential contributions of theoretically relevant genetic variation. Some of these studies have found sup port for a brain-derived neurotrophic factor (BDNF) variant, Val66Met, in the risk of developing PTSD, while others have failed to find this link. METHODS: This study sought to reconcile these conflicting findings using a meta-analysis framework...
June 6, 2018: Neuropsychobiology
Brian J Lithgow, Zahra Moussavi
Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women during their menses, and follicular and luteal phases of their menstrual cycle, and (2) compare these features to those observed in previous studies for depression with and without anxiety. Three EVestG recordings were made on 15 young healthy menstruating females during menses, and follicular and luteal phases...
2017: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2018: Neuropsychobiology
Flora Colledge, Serge Brand, Uwe Pühse, Edith Holsboer-Trachsler, Stefan Zimmerer, Ramona Schleith, Markus Gerber
OBJECTIVES: Deficits in psychological functioning, cognitive functioning, and sleep are frequently experienced by individuals who have survived aneurysmal subarachnoid haemorrhage (aSAH). Exercise has been shown to improve these domains; to date, it has never been explored in patients following aSAH. The aim of this exploratory study is to compare the effects of an exercise programme in this population with another patient group, and a group of healthy controls. METHODS: The present study explored the effects of 12 weeks of moderate aerobic exercise training on 15 aSAH patients, 16 meningioma patients, and 17 healthy controls...
April 25, 2018: Neuropsychobiology
Vesna Bryn, Robert Verkerk, Ola H Skjeldal, Ola Didrik Saugstad, Heidi Ormstad
BACKGROUND: There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory states, we aimed to determine whether this pathway is activated in ASD. METHODS: Sixty-five pediatric ASD patients (including 52 boys) were enrolled from an epidemiological survey covering 2 counties in Norway; 30 (46...
April 25, 2018: Neuropsychobiology
Mohammad Ahmadpanah, Amir Hosein Rahighi, Mohammad Haghighi
BACKGROUND: Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western Iran specifically. Here, we report sociodemographic, psychological, and psychiatric characteristics of patients attempting self-immolation (PSIs), compared to patients with accident burns (PABs). METHOD: Patients referred to the Burns Emergency Unit of the Besat Hospital (Hamadan, Iran) were enrolled in the present study between winter 2015 and summer 2016...
April 12, 2018: Neuropsychobiology
Ludovico Mineo, Carmen Concerto, Dhaval Patel, Tyrone Mayorga, Michael Paula, Eileen Chusid, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Valeriana officinalis extract (VE) is a popular herbal medicine used for the treatment of anxiety and sleep disorders. Although the anxiolytic and sedative effects are mainly attributed to the modulation of GABA-ergic transmission, the mechanism of action has not been fully investigated in humans. Noninvasive brain stimulation protocols can be used to elucidate the mechanisms of action of psychoactive substances at the cortical level in humans. In this study, we investigated the effects of a single dose of VE on cortical excitability as assessed with transcranial magnetic stimulation (TMS)...
October 17, 2017: Neuropsychobiology
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Neuropsychobiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"