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Polimery W Medycynie

Anna Fizia-Orlicz, Marta Misiuk-Hojło
According to the World Health Organization, cataract remains the leading cause of the curable visual impairment worldwide. Cataract can only be cured by surgery during which the cloudy lens is replaced with an artificial intraocular lens. It is one of the most common surgeries being performed worldwide. There are age-related, congenital, traumatic and metabolic types of cataract which have been distinguished. Age-related cataract is the most common one and it affects people over 60 with the greatest frequency...
July 2015: Polimery W Medycynie
Gabriela Wyszogrodzka, Przemysław Dorożyński
Metal-organic frameworks (MOFs) belong to the new class of mesoporous, hybrid materials composed of metal ions and organic binding ligands. Their unique features: wide range of chemical building components, which enables obtaining biocompatible materials, and high surface area and loading capacity, make them promising drug delivery vehicles for therapeutic agents. The ability to tune their structures and porosities provides better adjustment for adsorbed drug molecule. Moreover, MOFs functionalized with ligands or antibodies can be used in cancer targeted therapy...
July 2015: Polimery W Medycynie
Wojciech Andrzej Linka, Ilona Wojtaszek, Marian Mikołaj Zgoda, Michał Krzysztof Kołodziejczyk
BACKGROUND: Dry extracts are now frequently used in medicine as an alternative to synthetic drugs. In the case of tablet technology with dry plant extracts, the proper selection of disintegrants (superdisintegrants) is particularly important. Objectives. The aim of this study was to evaluate the usefulness of the polymers constituting superdisintegrants (Vivasol®, Vivastar®, Polyplasdone XL) in uncoated tablet formulation of alcoholic extracted from Asparagus officinalis. MATERIAL AND METHODS: Dry the ethanol extract of Asparagus officinalis, Vivasol®, Vivastar®, Vivapur®, Kollidon VA64, Polyplasdone XL, magnesium stearate...
July 2015: Polimery W Medycynie
Pramod Kumar Sharma, Rishabha Malviya
BACKGROUND: Oral delivery of drugs is the most common method, but due to the inability of drugs to restrain and localize in the gastro-intestinal tract, oral administration of drugs in conventional dosage forms have short-term limitations. Carrier technology may provide many approaches for the delivery of drugs by coupling the drug to a carrier particle, such as Microspheres, nanoparticles and liposomes, which modulate the release and absorption characteristics of the drug. OBJECTIVES: The aim of this study was to prepare Diclofenac sodium microspheres using a natural polymer and show the effect of calcium chloride on the release behavior of microspheres...
July 2015: Polimery W Medycynie
Manoj Kumar, Rajendra Awasthi
BACKGROUND: Crohn’s disease and ulcerative colitis are the main autoimmune inflammatory bowel diseases. Metronidazole is the most commonly used drug for the treatment of Crohn’s disease. However, the pharmacokinetic profile of this drug indicates that the largest amount of the drug is absorbed from the upper part of the intestines and very little concentration of the drugs reaches the colon.Objectives: The aim of this investigation was to formulate metronidazole loaded microspheres for the efficient therapy of inflammatory bowel diseases...
July 2015: Polimery W Medycynie
Andrzej Polski, Karol Iwaniak, Regina Kasperek, Joanna Modrzewska, Karolina Sobótka-Polska, Karolina Sławińska, Ewa Poleszak
BACKGROUND: The capsule is one of the most important solid dosage forms in the pharmaceutical industry. It is easier and faster to produce than a tablet, because it requires fewer excipients. Generally, capsules are easy to swallow and mask any unpleasant taste of the substances used while their release profiles can be easily modified. Papaverine hydrochloride was used as a model substance to show different release profiles using different excipients. OBJECTIVES: The main aim of the study was to analyze the impact of using different polymers on the release profile of papaverine hydrochloride from hard gelatin capsules...
July 2015: Polimery W Medycynie
Joanna Monika Kobierska-Brzoza, Maciej Dobrzyński, Katarzyna Agnieszka Fita, Dorota Bader-Orłowska, Maria Szymonowicz
Conservative treatment which restores the function, aesthetics and protects remaining tooth structure, and what is the most important, the viability of the tooth pulp, is still needed. Dental fillings replace specialized tissues of the tooth that have been lost due to caries or injury. Any decision concerning the use of a particular restorative material should be individualized and based on the competence regarding the composition, properties and characteristics of the specific restorative material. This requires continuous updating of knowledge about available dental materials as well as education of patients who, according to actual models of dental care, should be active partners in the therapeutic process...
January 2015: Polimery W Medycynie
Katarzyna Filipecka, Mariusz Budaj, Bogdan Miskowiak, Małgorzata Makowska-Janusik, Jacek Filipecki
BACKGROUND: The polymeric materials: hydrogel, silicone--hydrogel and methacrylic acid are used in ophthalmology for the manufacture of contact lenses. It is important to research the structure of these materials, mainly the prevalence of free volumes. OBJECTIVES: The study has been conducted in order to comparison the presence of free volume gaps in the structure of the polymer soft contact lenses: Etafilcon A (hydrogel), Narafilcon A (silicone-hydrogel) and the polymer rigid gas permeable (RGP) contact lens (Fluor-Silicon-Methacrylat-Copolymer)...
January 2015: Polimery W Medycynie
Sumedha Panta, Rishabha Malviya, Pramod Sharma
BACKGROUND: This manuscript deals with the purification and characterization of Boswellia serrata gum as a suspending agent. The Boswellia serrata gum was purchased as crude material, purified and further characterized in terms of organoleptic properties and further micromeritic studies were carried out to characterize the polymer as a pharmaceutical excipient. The suspending properties of the polymer were also evaluated. The results showed that the extracted gum possesses optimum organoleptic as well as micromeritic and suspending properties...
January 2015: Polimery W Medycynie
Andrzej Polski, Regina Kasperek, Magdalena Rogowska, Karol Iwaniak, Karolina Sobòtka-Polska, Ewa Poleszak
BACKGROUND: In tablet production, the most important aspects are the physical properties of the tablets and their dissolution studies, which can be performed in four pharmacopoeial apparatuses. There are differences between them in construction and action, so differences in the results obtained are possible. OBJECTIVES: The aim of the study was to compare the release of a model drug substance (papaverine hydrochloride) from tablets in three pharmacopoeial dissolution apparatus: a basket, a paddle (closed system) and flow-through cell (open system)...
January 2015: Polimery W Medycynie
Tarique Ali Meer, Kailas Moravkar, Jaywant Pawar, Purnima Amin
UNLABELLED: Background. Starch is one of the most potential natural polymers used for various bio applications. Literature reports a num- ber of modification strategies such as physical, chemical, enzymatic and genetic to enhance the positive attributes and iron out the undesired features of neat starch. OBJECTIVES: To synthesize a crosslinked porous starch (CPS) as an efficient cargo for the delivery of calcium carbonate in an efficiently controlled manner for the treatment of hyperphosphatemia...
January 2015: Polimery W Medycynie
Dorota Kamińska, Mariusz Kusztal
The flood of scientific information increases the risk of research findings distortion. The authors brought attention to the possible pitfalls of statistical inference in biomedical research. Due to intentional or non-intentional errors in study design and size, data collection and inappropriate statistical analysis some of research findings are false or exaggerated. Researchers excessively motivated to publish all possible study results sometimes seek any possible way to achieve p-value less than 0.05. False-positive study results can be obtained in underpowered studies, excessive flexibility in study designs and participants recruitment, probing different control groups, creating special subgroups or changing statistical tests...
January 2015: Polimery W Medycynie
Jacek Filipecki, Agnieszka Kocela, Witold Korzekwa
BACKGROUND: Polymer materials based on hydrogel and silicone-hydrogel materials are commonly used in ophthalmology. It is important to research the structure of these materials, mainly the prevalence of free volumes. OBJECTIVES: The study has been conducted in order to determine the presence of free volume gaps in the structure of polymer hydrogel and silicone-hydrogel contact lenses. In addition, to demonstrate differences in the occurrence of free volumes between types of represented contact lenses...
October 2014: Polimery W Medycynie
Regina Kasperek, Łukasz Zimmer, Agnieszka Szalast-Pietrzak, Zbigniew Marzec, Ewa Poleszak
BACKGROUND: In the pharmaceutical technology there is a trend to produce tablets composed of several medicinal substances to increase therapeutic effect and reduce the frequency of drug administration. In the literature there are reports concerning pharmacological studies in which a potentiation of the effects has been observed after a co-administration of antidepressant imipramine and magnesium. Currently, there is no formulation on the market comprising imipramine and magnesium, therefore, it was decided to produce uncoated tablets...
October 2014: Polimery W Medycynie
Wojciech Andrzej Linka, Ewa Golenia, Marian Mikołaj Zgoda, Michał Krzysztof Kołodziejczyk
BACKGROUND: Halitosis and gingivitis are most common pathologies (15-60% of population) which, if left untreated, lead to periodontal diseases and tooth loss. OBJECTIVES: The aim of this study was to develop, based on polymers of dry sage extract and zinc gluconate, tablets intended for sucking and chewing that can be applied in the treatment of halitosis and gingivitis. MATERIAL AND METHODS: Dried aqueous sage extract, zinc gluconate, Pharmagum M, Prosolv SMCC90 and SMCCHD90, Vivapur 102, sorbitol, mannitol, ludipress...
October 2014: Polimery W Medycynie
Łukasz Zimmer, Regina Kasperek, Ewa Poleszak
BACKGROUND: Oral disintegrating tablet (ODT) dissolves or disintegrates in saliva and then it is swallowed. Diluent in direct compression formulation has a dual role: it increases bulk of the dosage form and it promotes binding of the constituent particles of the formulation. Hence, selection of diluent is important in tablets produced by direct compression method. OBJECTIVES: The aim of this work was to exame feasibility of preparing and optimizing oral disintegrating tablet formulation using β-cyclodextrin as a diluent...
October 2014: Polimery W Medycynie
Jadupati Malakar, Krishnagopal Das, Amit Kumar Nayak
BACKGROUND: The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention. OBJECTIVES: The study involves the development and optimization of in situ cross-linked matrix tablets for sustained salbutamol sulfate release. MATERIAL AND METHODS: In situ cross-linked matrix tablets of salbutamol sulfate were prepared by direct compression and optimized by response surface methodology based on 32 factorial design...
October 2014: Polimery W Medycynie
Olutayo Ademola Adeleye, Mbang Nyong Femi-Oyewo, Michael Ayodele Odeniyi
BACKGROUND: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics. OBJECTIVES: To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporating cissus gum as controlled release polymer. MATERIAL AND METHODS: Water (CW) and acetone (CA) extracts of cissus gum were obtained from Cissus populea stem and two methods - wet granulation and direct compression - were used to compress the tablet and compare it with xanthan gum (X) formulations...
October 2014: Polimery W Medycynie
Paweł Poznański, Sławomir Niedźwiecki
Animal-based models used in biomedical sciences allow to perform research that, conducted on humans, would be highly problematic because of bioethical and technical issues. Contemporary researchers race can lead to abuse, hence the need for special law regulations regarding this subject. This necessity reflected both in the EU and Polish legislation, and is rooted in the philosophical and moral achievements of Europe. EU legislation in this case takes the form of directives implemented in the legal systems of the member states...
October 2014: Polimery W Medycynie
Łukasz Zimmer, Regina Kasperek, Ewa Poleszak
Matrix tablets are the most popular method of oral drug administration, and polymeric materials have been used broadly in matrix formulations to modify and modulate drug release rate. The main goal of the system is to extend drug release profiles to maintain a constant in vivo plasma drug concentration and a consistent pharmacological effect. Polymeric matrix tablets offer a great potential as oral controlled drug delivery systems. Cellulose derivatives, like hydroxypropyl methylcellulose (HPMC) are often used as matrix formers...
July 2014: Polimery W Medycynie
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