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Transactions of the American Clinical and Climatological Association

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https://www.readbyqxmd.com/read/28790532/present-members
#1
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790531/deceased-members-1884-through-2016
#2
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790530/acca-presidents-past-and-present-and-spouses
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790529/american-clinical-and-climatological-association-meeting-locations-1884-2016
#4
(no author information available yet)
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2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790528/constitution-and-by-laws
#5
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790527/former-officers-1884-through-2016
#6
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790526/officers-and-council-2017
#7
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790525/officers-and-council-2016
#8
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790524/instructions-to-authors-transactions-of-the-american-clinical-and-climatological-association
#9
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790523/recorder-s-report
#10
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790522/accountants-compilation-report
#11
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790521/secretary-treasurer-s-report
#12
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790520/index
#13
(no author information available yet)
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790519/errata
#14
(no author information available yet)
[This corrects the article on p. lxxxi in vol. 127, PMID: 28066079.].
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790518/coordinated-management-of-academic-health-centers
#15
Jeffrey R Balser, William W Stead
Academic health centers (AHCs) are the nation's primary resource for healthcare discovery, innovation, and training. US healthcare revenue growth has declined sharply since 2009, and is forecast to remain well below historic levels for the foreseeable future. As the cost of education and research at nearly all AHCs is heavily subsidized through large transfers from clinical care margins, our institutions face a mounting crisis. Choices centering on how to increase the cost-effectiveness of the AHC enterprise require unprecedented levels of alignment to preserve an environment that nurtures creativity...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790517/future-directions-in-minimally-invasive-intervention
#16
Jonathan S Lewin
No abstract text is available yet for this article.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790516/the-molecular-basis-of-portal-hypertension
#17
Don C Rockey
Cirrhosis leads to portal hypertension and vascular abnormalities in multiple vascular beds. There is intense vasoconstriction in the liver and the kidneys, but also vasodilation in the other vascular beds, including the periphery, lungs, brain, and mesentery. The derangement in each of these beds leads to specific clinical disease. The vasoconstrictive phenotype in the liver ultimately leads to clinical portal hypertension, and is caused by an imbalance of vasoconstrictive and vasorelaxing molecules, which will be the focus of this review...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790515/transient-receptor-potential-melastatin-channel-family-member-2-friend-or-foe
#18
Joseph Y Cheung, Barbara A Miller
Transient receptor potential melastatin 2 (Trpm2) channels are nonvoltage-activated channels permeable to monovalent and divalent cations, and are expressed in heart, brain, kidney, vasculature, and hematopoietic cells. Trpm2 is overexpressed in bladder, lung, breast, liver, head, and neck cancers. Classically, Trpm2 activation induces cell injury and death by Ca(2+) overload or enhanced inflammatory response. Recent studies show that Trpm2 protects lungs from endotoxin-induced injury by reducing reactive oxygen species production in phagocytes; and improves cardiac function after ischemia-reperfusion injury by preserving mitochondrial respiration and cellular adenosine triphosphate levels while decreasing reactive oxygen species levels...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790514/the-vhl-tumor-suppressor-gene-insights-into-oxygen-sensing-and-cancer
#19
William G Kaelin
Mammalian cells sense changes in oxygen and transduce that information into adaptive changes in gene expression using a conserved pathway that converges on the heterodimeric transcription factor called hypoxia-inducible factor (HIF), which contains a labile alpha subunit and a stable beta subunit. In the presence of oxygen, the alpha subunit is hydroxylated on one (or both) of two highly conserved prolyl residues by an Egg-Laying Defective Nine (EglN) [also called Prolyl Hydroxylase Domain (PHD)] dioxygenase, which recruits an ubiquitin ligase complex containing the VHL tumor suppressor gene product...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790513/the-jeremiah-metzger-lecture-cancer-in-the-twenty-first-century-an-inside-view-from-an-outsider
#20
Edward J Benz
Cancer is not a single disease. The term refers to literally hundreds of illnesses sharing common features: inappropriate proliferation of imperfectly differentiated cell types, invasion of nearby vital structures, and spread to distant sites (metastasis). Invasiveness and metastasis distinguish cancers from benign tumors such as fibroids and meningiomas. Yet, each type is distinct, possessed of defining morphologic, histologic, biochemical, and genomic features that have allowed oncologists to develop a nosology that guides diagnosis and therapy...
2017: Transactions of the American Clinical and Climatological Association
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