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Revista do Instituto de Medicina Tropical de São Paulo

Felipe Francisco Tuon, Carolina Rocio Santos, Juliette Cieslinski, Regina Maia de Souza, Rui Imamura, Valdir Sabbaga Amato
No abstract text is available yet for this article.
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Yu-Kang Chang, Kou-Huang Chen, Kow-Tong Chen
Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and control. The morbidity rate of EV-A71 infection differs between countries. The pathogen's genetic lineages are undergoing rapid evolutionary changes. An association between the occurrence of EV-A71 infection and the circulation of different genetic strains of EV-A71 virus has been identified around the world...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Fernanda Gil de Souza, Francini Pereira da Silva, Rodrigo Staggemeier, Caroline Rigotto, Fernando Rosado Spilki
Hepatitis A virus (HAV), a member of Picornaviridae family, is the main causative agent of acute viral hepatitis in the world, mainly in developing countries. HAV may be present in contaminated water and food and its presence is often associated to a lesser extent with socioeconomic factors and environmental quality. The main goals in the present study were to standardize a cell culture combined to a polymerase chain reaction protocol for the detection and quantification of viral viability and analyze whether the virus could be found in water samples collected in four urban streams of Sinos River watershed...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Denise Costa Boamorte Cortela, Maria Renata Sales Nogueira, Ana Carla Pereira, Alcione Lescano de Souza Junior, Eliane Ignotti
The inflammatory cytokines involved in the immune response to chronic periodontal disease (CPD) in the context of leprosy reactions (LR) were analyzed in 57 new cases of multibacillary leprosy (MBL). They were stratified by the presence of CPD and LR. Messenger RNA (mRNA) expression of inflammatory mediators was determined by qRT-PCR using skin biopsy and by ELISA using serum samples, maintaining 5% of significance level in ANOVA and correlation analyses. Twenty-three (40.4%) patients presented the first LR, whereas 22 (45...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Leticia Ferrigolo Zanella, Iara Beatriz Andrade de Sousa, Marcelo Dos Santos Barbosa, Odival Faccenda, Simone Simionatto, Silvana Beutinger Marchioro
Leprosy remains a public health problem in Brazil, and the Mato Grosso do Sul State (MS) had the seventh highest rate of detection of new cases in the country in 2015 (26.59 per 100,000 inhabitants) which was classified as very high. This work aimed to determine the epidemiological characteristics of leprosy in MS. Descriptive statistics were performed with data from the Information System on Diseases of Compulsory Declaration (SINAN) between 2001 and 2015, with all patients included in the system serving as the sample...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Amanda Gabryelle Nunes Cardoso Mello, Michelle Valéria Dias Ferreira Vieira, Luann Wendel Pereira de Sena, Thiago Portal da Paixão, Ana Carla Godinho Pinto, Daniella Paternostro de Araújo Grisólia, Margareth Tavares Silva, José Luiz Fernandes Vieira
In the last two years, a substantial increase in the number of malaria vivax cases has occurred in the Brazilian Amazon basin. The adequate exposure of hypnozoites to primaquine is a matter of interest as these dormant forms are responsible for the maintenance or even the increase of malaria burden in endemic areas. The aim of this study was to estimate the levels of primaquine and carboxyprimaquine in whole blood samples of patients with P. vivax treated with chloroquine and an abbreviated regimen of primaquine (0...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Guilherme Almeida Rosa da Silva, Heloisa Loureiro de Sá Neves Motta, Erik Friedrich Alex de Souza, Pedro Afonso Nogueira Moises Cardoso, José Henrique Pilotto, Walter Araujo Eyer-Silva, Luiz Cláudio Pereira Ribeiro, Mônica Soares Dos Santos, Marcelo Costa Velho Mendes de Azevedo, Jorge Francisco da Cunha Pinto, Rogerio Neves Motta, Fernando Raphael de Almeida Ferry
A prevalence of 3.47% of asymptomatic Chlamydia trachomatis urethritis has been previously reported among males living with HIV infection in Brazil. This study aims to assess the recurrence of C. trachomatis urethritis three years later in the same cohort of patients and analyze associated risk factors. A total of 115 male patients diagnosed with HIV infection, with no symptoms of urethritis and observed since May of 2015 in followup visits were enrolled. They had urine samplers tested by PCR for C. trachomatis and N...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Vivian Iida Avelino-Silva, Conrado Alvarenga, Carolina Abreu, Tania Regina Tozetto-Mendoza, Cynthia Liliane Motta do Canto, Erika Regina Manuli, Maria Cassia Mendes-Correa, Ester Cerdeira Sabino, Walter Manso Figueiredo, Aluísio Cotrim Segurado, Philippe Mayaud
BACKGROUND: Zika virus (ZIKV) sexual transmission and prolonged viral shedding in semen have been previously reported, suggesting a strong viral affinity for genital tissues. A transient impact of ZIKV on male fertility was shown in animal and human studies. METHODS: Adult male patients with confirmed ZIKV infection diagnosed in the city of Araraquara, Brazil during the epidemic season of 2016 were invited one year after the acute infection to respond to a questionnaire of genital symptoms and to provide a semen sample for molecular ZIKV testing and spermogram analysis, as well as a serum sample for hormonal testing...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Jocieli Malacarne, Ida Viktoria Kolte, Lais Picinini Freitas, Jesem Douglas Yamall Orellana, Maximiliano Loiola Ponte de Souza, Reinaldo Souza-Santos, Paulo Cesar Basta
The Mato Grosso do Sul State (MS) has the second-largest indigenous population and the highest incidence rates of TB among indigenous people in Brazil. However, little is known about the risk factors associated with active TB in indigenous people in the region, especially regarding socioeconomic factors. The aim of this study is to assess the effect of the Family Allowance Program (BFP) and of other predictors of active TB in a high-risk indigenous population in Brazil. We conducted a case-control study with incident TB cases matched by age and by village of residence (1:2 proportion) between March 2011 and December 2012...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Silmery da Silva Brito Costa, Maria Dos Remédios Freitas Carvalho Branco, José Aquino Junior, Zulimar Márita Ribeiro Rodrigues, Rejane Christine de Sousa Queiroz, Adriana Soraya Araujo, Ana Patrícia Barros Câmara, Polyana Sousa Dos Santos, Emile Danielly Amorim Pereira, Maria do Socorro da Silva, Flávia Regina Vieira da Costa, Amanda Valéria Damasceno Dos Santos, Maria Nilza Lima Medeiros, José Odval Alcântara Júnior, Vitor Vieira Vasconcelos, Alcione Miranda Dos Santos, Antônio Augusto Moura da Silva
Dengue fever, chikungunya fever, and zika virus infections are increasing public health problems in the world, the last two diseases having recently emerged in Brazil. This ecological study employed spatial analysis of probable cases of dengue fever, chikungunya fever, and zika virus infections reported to the National Mandatory Reporting System (SINAN) in Maranhao State from 2015 to 2016. The software GeoDa version 1.10 was used for calculating global and local Moran indices. The global Moran index identified a significant autocorrelation of incidence rates of dengue (I=0...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Inês Stranieri, Kelly Aparecida Kanunfre, Jonatas Cristian Rodrigues, Lidia Yamamoto, Maria Isabel Valdomir Nadaf, Patricia Palmeira, Thelma Suely Okay
Bacterial sepsis remains a major cause of mortality and blood cultures are the gold standard of laboratory diagnosis even though they lack sensitivity in neonates. Culturenegative sepsis, also known as clinical sepsis, has long been considered a diagnosis in neonatal intensive care units because, as well as culture-positive infants, culture-negative neonates have worse prognosis in comparison with non-infected ones. Quantitative amplifications are used to detect bacterial infections in neonates but results are considered only in a qualitative way (positive or negative)...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Thaísa Cristina Silva, Ana Laura de Sene Amâncio Zara, Fabyola Amaral da Silva Sá, Maria Teresa Freitas Bara, Renato Ivan de Ávila, Carolina Rodrigues Costa, Marize Campos Valadares, Andressa Santana Dos Santos, Vivianny Aparecida Queiroz Freitas, Maria do Rosário Rodrigues Silva
This study evaluated the antifungal activity and cytotoxicity profile of the ellagitannin punicalagin, a compound extracted from the L. pacari A. St.-Hil (Lythraceae) leaf, against Cryptococcus neoformans species complex. Minimum inhibitory concentrations (MIC) were checked using the broth microdilution method. Minimum fungicidal concentrations (MFC) and time of death were used to confirm the antifungal activity of the compound. The in vitro cytotoxicity of punicalagin was tested in BALB/c3T3 fibroblasts and A549 human lung cancer cell line, while the hemolytic potential was tested on sheep erythrocytes...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Katia Regina Assunção Borges, Igor Vinícius Pimentel, Lidiane Cristina Lima Dos Santos Lucena, Marcos Antonio Custódio Neto da Silva, Silvio Gomes Monteiro, Cristina Andrade Monteiro, Maria do Desterro Soares Brandão Nascimento, Geusa Felipa de Barros Bezerra
INTRODUCTION: Candida parapsilosis is one of the main species that is able to adhere to forming biofilms on inert materials. Adhesion is the first step towards the colonization and invasion of host cells during the infectious process. Among the infections, vulvovaginal candidiasis is increasingly common. The objective was to evaluate the profile of adherence and biofilm formation of eight isolates of C. parapsilosis on the metal used in intrauterine devices (IUDs). METHODS: Eight strains of C...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Taniela Marli Bes, Roberta Ruedas Martins, Lauro Perdigão, Diego Mongelos, Luisa Moreno, Andrea Moreno, Gerson Salvador de Oliveira, Silvia Figueiredo Costa, Anna Sara Levin
Staphylococcus aureus (SA) is a commensal habitant of nasal cavities and skin. Colonization by community-acquired methicillin-resistant SA (CA-MRSA) is associated with infections in patients who have not been recently hospitalized. The aim of this study is to determine the prevalence of MRSA colonization in an outpatient population, currently unknown in Brazil. Three-hundred patients or caregivers from two teaching hospitals were included. A questionnaire was applied and nasal swabs were obtained from patients...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Francielle Beltrão Pereira, Walderez O Dutra, Kenneth J Gollob, Edna Afonso Reis, Ana Laura Grossi de Oliveira, Manoel Otávio da Costa Rocha, Cristiane Alves da Silva Menezes
The vasoactive intestinal peptide (VIP) expression is lower in cardiac chagasic patients and is related to worse cardiac function. The reduction of VIP in patients with Chagas disease may be a result of its enhanced degradation. To test this hypothesis, the tryptase and chymase expression was evaluated. We also related VIP levels with interleukin-17 (IL-17) expression since VIP may modulate IL-17 production. Plasma levels of chymase were higher in chagasic patients. Conversely, VIP/chymase and VIP/tryptase ratios were lower in chagasic patients when compared to non-infected individuals...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Benjawan Phetsuksiri, Sopa Srisungngam, Janisara Rudeeaneksin, Supranee Boonchu, Wiphat Klayut, Ronnayuth Norrarat, Somchai Sangkitporn, Yuthichai Kasetjaroen
Interferon-gamma (IFN-γ) release assays have improved latent tuberculosis (TB) detection and have been considered promising for the diagnosis of TB disease. However, diagnosis efficacy data is limited in high burden countries. The aim of this study was to determine the diagnostic potential of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test for the diagnosis of active TB in an endemic setting for TB. A cross-sectional study was conducted in a group of 102 Thai patients with clinical symptoms and chest x-ray findings suggesting of active pulmonary TB and a group of 112 healthy adults...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
María Soledad Santini, Mariana Manteca Acosta, Maria Eugenia Utgés, Maria Esther Aldaz, Oscar Daniel Salomón
The objective of this study was to evaluate the presence of Lutzomyia longipalpis in the Argentine city of Concordia, in the province of Entre Rios, without record of this species despite previous samplings, but with canine cases of visceral leishmaniasis and Lu. longipalpis reports both, from Northern Argentine localities and from the city of Salto, Uruguay, located just across the river and the international border. This study confirms the presence of Lu. longipalpis and Nyssomyia whitmani, related to the risk of visceral and tegumentary leishmaniasis, respectively, in Concordia-Entre Rios...
October 22, 2018: Revista do Instituto de Medicina Tropical de São Paulo
(no author information available yet)
[This corrects the article doi: 10.1590/S1678-9946201860051].
October 11, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Julian E Garcia-Rejon, Armando Ulloa-Garcia, Nohemi Cigarroa-Toledo, Angelica Pech-May, Carlos Machain-Williams, Rosa Carmina Cetina-Trejo, Lourdes Gabriela Talavera-Aguilar, Oswaldo Margarito Torres-Chable, Juan Carlos Navarro, Carlos Marcial Baak-Baak
Aedes aegypti is the vector of the arboviruses causing dengue, chikungunya and zika infections in Mexico. However, its presence in public places has not been fully evaluated. In a cemetery from Merida, Yucatan, Mexico, the productivity of Ae. aegypti, the gonotrophic cycle, and the presence of Ae. aegypti females infected with arboviruses were evaluated. Immature and adult mosquitoes were inspected every two months between April 2016 to June 2017. For the gonotrophic cycle length, the daily pattern of total and parous female ratio was registered and was analyzed using time series analysis...
August 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Thaísa Regina Rocha Lopes, Caroline Simões Silva, André Filipe Pastor, José Valter Joaquim Silva Júnior
No abstract text is available yet for this article.
August 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
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