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Revista da Sociedade Brasileira de Medicina Tropical

Sebastian Vernal, Maria Jose Franco Brochado, Roberto Bueno-Filho, Paulo Louzada-Junior, Ana Maria Roselino
INTRODUCTION: Corticosteroids and/or thalidomides have been associated with thromboembolism events (TBE) in multibacillary (MB) leprosy. This report aimed to determine genetic and laboratory profiles associated with leprosy and TBE. METHODS: Antiphospholipid antibodies (aPL), coagulation-related exams, prothrombin and Leiden's factor V mutations, and ß2-glycoprotein-I (ß2GPI) Val247Leu polymorphism were assessed. RESULTS: Six out of seven patients with leprosy were treated with prednisone and/or thalidomide during TBE and presented at least one positive aPL...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Thaís Silva Peleteiro, Evelin Santos Oliveira, Elisabete Lopes Conceição, Francisco Nascimento-Sampaio, Neuza Maria Alcântara-Neves, Carlos Mauricio Cardeal Mendes, Theolis Costa Barbosa Bessa
INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Roya Ghanavati, Mohammad Emaneini, Davood Kalantar-Neyestanaki, Azin Sattari Maraji, Mosayyeb Dalvand, Reza Beigverdi, Fereshteh Jabalameli
INTRODUCTION: Here, we determined the genes encoding antibiotic resistance enzymes and virulence factors and evaluated the genetic relationship between Enterobacter spp. isolated from different clinical samples. METHODS: A total of 57 clinical isolates of Enterobacter spp. were tested for the production of extended-spectrum β-lactamases (ESBLs), carbapenemase, and AmpC using phenotypic and genotypic methods. RESULTS: The most common ESBLs and AmpC β-lactamases were bla TEM (63...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Lucas Eduardo Trevisoli, Larissa Bail, Luiza Souza Rodrigues, Danieli Conte, Jussara Kasuko Palmeiro, Libera Maria Dalla-Costa
INTRODUCTION.: This study aimed to evaluate different methods for differentiation of species of coagulase-negative staphylococci (CoNS) that caused infections in hospitalized immunocompromised patients. METHODS.: A total of 134 CoNS strains were characterized using four different methods. RESULTS.: The results of matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) analysis were in complete agreement with those of tuf gene sequencing (kappa index = 1...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Allyson Guimarães Costa, Bárbara Aparecida Chaves, Felipe Leão Gomes Murta, Jacqueline Almeida Gonçalves Sachett, Vanderson Souza Sampaio, Vanessa Costa Silva, Wuelton Marcelo Monteiro
INTRODUCTION: Hymenoptera injuries are commonly caused by stinging insects. In Amazonas state, Brazil, there is no information regarding distribution, profile, and systemic manifestations associated with Hymenoptera injuries. METHODS: This study aimed to identify risk factors for systemic manifestation using the Brazilian Notifiable Diseases Surveillance System (2007 to 2015). RESULTS: Half of Hymenoptera injuries were caused by bee stings...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Leandro José Ramos, Janis Lunier de Souza, Cláudio Rodrigues de Souza, Jader de Oliveira, João Aristeu da Rosa, Luis Marcelo Aranha Camargo, Renildo Moura da Cunha, Dionatas Ulises de Oliveira Meneguetti
INTRODUCTION: The occurrence of Triatoma sordida in the Brazilian Western Amazon is reported for the first time. METHODS: Triatoma sordida specimens were collected from a Gallus gallus nest in a peridomiciliary area of Senador Guiomard municipality in the state of Acre. RESULTS: The number of triatomine species in Acre increased from six to seven with this first report of T. sordida in the Brazilian Western Amazon. CONCLUSIONS: The occurrence of T...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Açucena Veleh Rivas, Renata Defante, Robson Michael Delai, Jean Avemir Rios, André da Silva Britto, André de Souza Leandro, Daniela Dib Gonçalves
INTRODUCTION: the Building Infestation Index (BII) uses the Rapid Assay of the Larval Index for Aedes aegypti (LIRAa) to express the relationship between positive and surveyed properties. We evaluated LIRAa and the relationship between the BII and climate variables for dengue cases in Foz do Iguaçu municipality, Paraná. METHODS: Spearman's correlations for mean precipitation, mean temperature, BII, and dengue cases (time lag). RESULTS: positive correlations between BII and cases, and mean temperature and cases at two months...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Catarina Oliveira Paulo, Sofia Jordão, João Correia-Pinto, Fernando Ferreira, Isabel Neves
Actinomycosis remains characteristically uncommon, but is still an important cause of morbidity. Its clinical presentation is usually indolent and chronic as slow growing masses that can evolve into fistulae, and for that reason are frequently underdiagnosed. Actinomyces spp is often disregarded clinically and is classified as a colonizing microorganism. In this review of literature, we concomitantly present 11 cases of actinomycosis with different localizations, diagnosed at a tertiary hospital between 2009 and 2016...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Sabrina Ribeiro de Almeida Queiroz, José Valter Joaquim Silva Júnior, Andréa Nazaré Monteiro Rangel da Silva, Amanda Gomes de Oliveira Carvalho, Jefferson José da Silva Santos, Laura Helena Vega Gonzales Gil
INTRODUCTION: Pseudo-infectious yellow fever viral particles (YFV-PIVs) have been used to study vaccines and viral packaging. Here, we report the development of a packaging cell line, which expresses the YFV prM/E proteins. METHODS: HEK293 cells were transfected with YFV prM/E and C (84 nt) genes to generate HEK293-YFV-PrM/E-opt. The cells were evaluated for their ability to express the heterologous proteins and to package the replicon repYFV-17D-LucIRES, generating YFV-PIVs...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Luciano Pamplona de Góes Cavalcanti, Sara Mendes D'angelo, Daniele Rocha Queiroz Lemos, Francisca Kalline de Almeida Barreto, André Machado Siqueira, Fabio Miyajima
INTRODUCTION: Chikungunya virus (CHIKV) can negatively influence outcomes in patients with pre-existing conditions. We investigated the association between the recent CHIKV outbreak and increased type 2 diabetes (T2D)-attributable deaths. METHODS: Monthly averages of T2D-attributable deaths between 2001 and 2016 were determined and compared to the equivalent data for 2017 and the recent CHIKV outbreak. RESULTS: CHKV outbreak peaked in April 2017 with 4,394...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Juliana Boaventura Avelar, Marcos Gontijo da Silva, Hanstter Hallison Alves Rezende, Heloisa Ribeiro Storchilo, Waldemar Naves do Amaral, Isolina Rodrigues Xavier, Mariza Martins Avelino, Ana Maria de Castro
INTRODUCTION: Knowledge of the epidemiological profile and risk factors for Toxoplasma gondii infection among postpartum women is a relevant issue, because this protozoan can be vertically transmitted to the developing fetus, which can cause severe and debilitating disease. The aim of this study was to assess the risk factors associated with T. gondii infection in postpartum women in Goiânia, GO, Brazil. METHODS: This cross-sectional study comprised 229 postpartum women, among whom 204 were chronically infected (IgG+/IgM-), and 25 were seronegative (IgG-/IgM-; control group)...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Angela Maria Lourenço, Cristiane Castro Faccini, Cristiane Aparecida de Jesus Costa, Gabrielle Balestrin Mendes, Abilio Augusto Fragata Filho
INTRODUCTION: Approximately seven to eight million people worldwide have Chagas disease. In Brazil, benznidazole is the most commonly used active drug against Trypanosoma cruzi; however, its efficacy is limited, and side effects are frequent. Recent studies suggest that amiodarone may be beneficial in the treatment of this disease, by exerting anti-T. cruzi action. This study evaluated changes in T. cruzi cell count in in vitro cultures subjected to different doses of benznidazole, amiodarone, and their combination...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Zahra Hashemizadeh, Davood Kalantar-Neyestanaki, Shahla Mansouri
INTRODUCTION: Multidrug-resistant (MDR) Escherichia coli, a species that is a leading cause of urinary tract infections (UTIs) and is a major global public health concern. This study was designed to detect the differences in antibiotic resistance patterns, the production and type of extended spectrum β-lactamases (ESBLs), and the clonal relationships among E. coli isolates from UTIs and fecal samples. METHODS: Antibacterial resistance was determined by the disk diffusion method...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Thaila Francini Corona, Beatriz Böger, Tatiana Carneiro da Rocha, Walfrido Külh Svoboda, Eliane Carneiro Gomes
INTRODUCTION: Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold standard). Studies conducted over the past three decades indicate that MIT and Virus Isolation in Cell Culture (VICC) can provide the same effectiveness, the latter being considered superior in bioethics and animal welfare...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Tatiana Schäffer Gregianini, Claudete Farina Seadi, Ivone Menegolla, Letícia Garay Martins, Nilo Ikuta, Jonas Michel Wolf, Vagner Ricardo Lunge
INTRODUCTION: Infections caused by respiratory viruses are important problems worldwide, especially in children. Human metapneumovirus (hMPV) is a respiratory pathogen and causes severe infections with nonspecific symptoms. This study reports the hMPV occurrence and dissemination in southern Brazil and compares the frequency of occurrence of this virus and the human respiratory syncytial virus (hRSV) in the epidemiological weeks in a three-year period (2009-2011). METHODS: In total, 545 nasopharyngeal (NP) specimens from individuals with Severe Acute Respiratory Syndrome (SARS) who were negative for other seven respiratory viruses were analyzed for the presence of hMPV...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Aletheia Soares Sampaio, Ana Lucia Ribeiro de Vasconcelos, Clarice Neuenschwander Lins de Morais, George Tadeu Nunes Diniz, Anna Lígia de Castro Figueiredo, Sílvia Maria Lucena Montenegro
INTRODUCTION: The functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of this study was to correlate social status with levels of interleukin (IL)-10 (non-inflammatory) and interferon-gamma (IFN-γ; inflammatory) cytokines. METHODS: A cross-sectional study was conducted with three groups of women: 33 pregnant HIV-infected (G1); 40 non-pregnant, HIV-infected (G2); and 35 pregnant, HIV-uninfected...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Afranio Kritski, Kleydson Bonfim Andrade, Rafael Mello Galliez, Ethel Leonor Noia Maciel, Marcelo Cordeiro-Santos, Silvana Spindola Miranda, Teresa Scatena Villa, Antonio Ruffino Netto, Denise Arakaki-Sanchéz, Julio Croda
This article reviews tuberculosis control actions performed over the last decade, at a global level. The perspectives for the fulfillment of the goals of the new Global Tuberculosis Elimination Plan are described, where the insertion of social protection (Pillar 2) and research (Pillar 3) will play an innovative and strategic role, especially in high-burden countries, like Brazil.
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Cirley Maria de Oliveira Lobato, Natalia Balassiano, Elodie Bomfim Hyppolito, Rafaela Liz Pellegrim Sanchez-Lermen, Izabelle Venturini Signorelli, Miguel Yasuo Tomita Nicacio, Alberto Pereira Firmino Filho, Thais Guaraná de Andrade, José Milton de Castro Lima, Talita Amorim de Arruda, Fernanda Schwanz Coutinho, Everton Felipe do Vale Araujo, Ticiana Mota Esmeraldo, Erlon Cortez, Rafaela Lorenzon Aragão Capeli, Melquior Brunno Mateus de Matos, Francisco Sérgio Rangel Pessoa, Hélder Cássio de Oliveira, Érico Antônio Gomes de Arruda, Patrícia Lofêgo Gonçalves, Antônio Haroldo Araújo Filho, Eliane Bordalo Cathalá Esberard, Francisco José Dutra Souto
INTRODUCTION: In 2013, combination therapy using peginterferon, ribavirin, and boceprevir or telaprevir was introduced to treat hepatitis C virus genotype 1 infection in Brazil. The effectiveness of this therapy in four Brazilian regions was evaluated. METHODS: Clinical and virological data were obtained from patients of public health institutions in five cities, including sustained virological response (SVR) and side effects. Patients with advanced fibrosis (F3/4), moderate fibrosis (F2) for > 3 years, or extra-hepatic manifestations were treated according to Ministry of Health protocol...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Edgar Marcelino Carvalho, Alejandro Llanos-Cuentas, Gustavo Adolfo Sierra Romero
No abstract text is available yet for this article.
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Walter de Araujo Eyer-Silva, Fabio Bettini Pitombo, Guilherme Almeida Rosa da Silva
No abstract text is available yet for this article.
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
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