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Archives of Virology

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https://www.readbyqxmd.com/read/29340806/distribution-of-il28b-and-il10-polymorphisms-as-genetic-predictors-of-treatment-response-in-pakistani-hcv-genotype-3-patients
#1
Humaira Naeemi, Rabia Aslam, Syed Mohsin Raza, Muhammad Aiman Shahzad, Shagufta Naz, Sobia Manzoor, Saba Khaliq
There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pathogenesis and clearance of HCV, and sustained virologic response (SVR). An interleukin 28B (IL28B) gene polymorphism has been shown to modify treatment outcomes, but the effects of interleukin 10 (IL10) polymorphisms have not been previously assessed in the Pakistani population...
January 16, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327238/the-complete-genome-sequence-of-hetpv20-an1-an-alphapartitivirus-infecting-the-conifer-pathogenic-fungus-heterobasidion-annosum
#2
Eeva J Vainio
Root rot fungi of the genus Heterobasidion are highly destructive conifer pathogens in the northern Boreal forest region. This report describes the complete genome sequence of Heterobasidion partitivirus 20 infecting a Finnish strain of Heterobasidion annosum. The bisegmented dsRNA genome of HetPV20-an1 encodes a predicted RNA-dependent RNA polymerase of 605 amino acids (aa) and a capsid protein of 536 aa. Based on sequence similarity and phylogenetic analysis, this virus is a new member of the genus Alphapartitivirus...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327237/regional-age-and-respiratory-secretion-specific-prevalence-of-respiratory-viruses-associated-with-asthma-exacerbation-a-literature-review
#3
REVIEW
Xue-Yan Zheng, Yan-Jun Xu, Wei-Jie Guan, Li-Feng Lin
Despite increased understanding of how viral infection is involved in asthma exacerbations, it is less clear which viruses are involved and to what extent they contribute to asthma exacerbations. Here, we sought to determine the prevalence of different respiratory viruses during asthma exacerbations. Systematic computerized searches of the literature up to June 2017 without language limitation were performed. The primary focus was on the prevalence of respiratory viruses, including AdV (adenovirus), BoV (bocavirus), CoV (coronavirus), CMV (cytomegalovirus), EnV (enterovirus), HSV (herpes simplex virus), IfV (influenza virus), MpV (metapneumovirus), PiV (parainfluenzavirus), RV (rhinovirus) and RSV (respiratory syncytial virus) during asthma exacerbations...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327236/complete-genome-sequence-and-construction-of-an-infectious-full-length-cdna-clone-of-a-german-isolate-of-celery-mosaic-virus
#4
Hanna Rose, Edgar Maiss
The complete genome sequence of a German isolate of celery mosaic virus (CeMV, a potyvirus) from Quedlinburg (DSMZ PV-1003) was determined (MF962880). This represents the second fully sequenced genome of this virus, along with a Californian isolate (HQ676607.1). The positive-sense single-stranded RNA is 10,000 nucleotides in length and shows the typical organization of potyviruses but has a shorter PIPO than CeMV California. In comparison to CeMV isolates from different origins, CeMV-Quedlinburg and isolates from the Netherlands (AF203531...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327235/complete-genome-sequence-of-a-phage-hyperparasite-of-candidatus-xenohaliotis-californiensis-rickettsiales-a-pathogen-of-haliotis-spp-gasteropoda
#5
Roberto Flores, Jorge Cáceres-Martínez, Miguel Ángel Del Río-Portilla, Alexei F Licea-Navarro, Ricardo Gonzales-Sánchez, Abraham Guerrero
Bacteriophages are recognized as major mortality agents of microbes, among them intracellular marine rickettsiales-like bacteria. Recently, a phage hyperparasite of Candidatus Xenohaliotis californiensis (CXc) has been described. This bacterium is considered the causal agent of Withering Syndrome (WS) which is a chronic and potentially lethal disease of abalone species from California, USA and the peninsula of Baja California, Mexico. This hyperparasite which infects CXc could be used as a biocontrol agent for WS...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327234/antiviral-effect-of-lithium-chloride-on-replication-of-avian-leukosis-virus-subgroup-j-in-cell-culture
#6
Kun Qian, Xiaowei Cheng, Danyang Zhang, Hongxia Shao, Yongxiu Yao, Venugopal Nair, Aijian Qin
Lithium chloride (LiCl) has been reported to possess antiviral activity against several viruses. In the current study, we assessed the antiviral activity effect of LiCl on ALV-J infection in CEF cells by using real-time PCR, Western blot analysis, IFA and p27 ELISA analysis. Our results showed that both viral RNA copy number and protein level decreased significantly in a dose and time dependent manner. Time-course analysis revealed that the antiviral effect was more pronounced when CEFs were treated at the post infection stage rather than at early absorption or pre-absorption stages...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327233/dcaf1-is-involved-in-hcv-replication-through-regulation-of-mir-122
#7
Yanling Yan, Conghui Li, Binlian Sun, Rongge Yang
Hepatitis C virus (HCV) is a worldwide threaten to human health with a high ratio of chronic infections. Recently, we found that Vpr-mediated regulation of HCV replication depends on the host protein DDB1-Cul4 associate factor 1 (DCAF1), implying that DCAF1 might be involved in the replication of HCV. In this study, we demonstrated that DCAF1 knockdown reduced HCV replication both in the infectious (JFH1) and replicon (Con1) systems. Further investigation showed a negative regulation of HCV internal ribosome entry site (IRES)-mediated translation by DCAF1...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327232/comparative-evaluation-of-the-omniplex-hpv-and-rfmp-hpv-papillotyper-for-detecting-human-papillomavirus-genotypes-in-cervical-specimens
#8
Young Ahn Yoon, Bo-Hyun Kim, Su-Hak Heo, Hwi Jun Kim, Young-Jin Choi
Human papillomavirus (HPV) is a major cause of cervical neoplasia development. HPV screening is very important because early treatment can prevent cervical cancer. Omniplex-HPV is a polymerase chain reaction followed by Luminex xMAP bead microarray technology that is designed for detecting 40 HPV genotypes. The aim of this study is to evaluate the analytical and clinical performance of the Omniplex-HPV in comparison with that of the commercially available RFMP (restriction fragment mass polymorphism) HPV PapilloTyper...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29322273/the-emerging-influenza-virus-threat-status-and-new-prospects-for-its-therapy-and-control
#9
REVIEW
Binod Kumar, Kumari Asha, Madhu Khanna, Larance Ronsard, Clement Adebajo Meseko, Melvin Sanicas
Influenza A viruses (IAVs) are zoonotic pathogens that cause yearly outbreaks with high rates of morbidity and fatality. The virus continuously acquires point mutations while circulating in several hosts, ranging from aquatic birds to mammals, including humans. The wide range of hosts provides influenza A viruses greater chances of genetic re-assortment, leading to the emergence of zoonotic strains and occasional pandemics that have a severe impact on human life. Four major influenza pandemics have been reported to date, and health authorities worldwide have shown tremendous progress in efforts to control epidemics and pandemics...
January 10, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29322272/a-novel-passerivirus-family-picornaviridae-in-an-outbreak-of-enteritis-with-high-mortality-in-estrildid-finches-uraeginthus-sp
#10
Péter Pankovics, Ákos Boros, Tung Gia Phan, Eric Delwart, Gábor Reuter
An enteric outbreak with high mortality (34/52, 65.4%) was recorded in 2014 in home-reared estrildid finches (Estrildidae) in Hungary. A novel passerivirus was identified in a diseased violet-eared waxbill using viral metagenomics and confirmed by RT-(q)PCR. The complete genome of finch picornavirus strain waxbill/DB01/HUN/2014 (MF977321) showed the highest amino acid sequence identity of 38.9%, 61.6%, 69.6% in P1cap, 2Chel and 3CproDpol, respectively, to passerivirus A1 (GU182406). A high viral load (6.58 × 1010 genomic copies/ml) was measured in a cloacal specimen and in the tissues (spinal cord, lung, and the intestines) of two additional affected finches...
January 10, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29318374/role-of-ribavirin-in-the-treatment-of-hepatitis-c-virus-associated-mixed-cryoglobulinemia-with-interferon-free-regimens
#11
Lucio Boglione, Jessica Cusato, Simone Mornese Pinna, Amedeo De Nicolò, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio
Mixed cryoglobulinemia (MC) is the most common extrahepatic manifestation of chronic hepatitis C (CHC), with the presence of symptoms in 10-15% of cases. There have been encouraging data regarding immunological and clinical responses in patients treated with the novel combinations of direct-acting antivirals (DAAs), but the role of ribavirin (RBV) in the treatment of MC has not yet been demonstrated. We prospectively enrolled 132 patients affected by MC and CHC, and virological, immunological and clinical responses were evaluated at 12 weeks after completion of treatment...
January 9, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29308543/chromogenic-detection-of-yam-mosaic-virus-by-closed-tube-reverse-transcription-loop-mediated-isothermal-amplification-ct-rt-lamp
#12
Chukwuemeka K Nkere, Joshua O Oyekanmi, Gonçalo Silva, Moritz Bömer, Gabriel I Atiri, Joseph Onyeka, Norbert G Maroya, Susan E Seal, P Lava Kumar
A closed-tube reverse transcription loop-mediated isothermal amplification (CT-RT-LAMP) assay was developed for the detection of yam mosaic virus (YMV, genus Potyvirus) infecting yam (Dioscorea spp.). The assay uses a set of six oligonucleotide primers targeting the YMV coat protein region, and the amplification products in YMV-positive samples are visualized by chromogenic detection with SYBR Green I dye. The CT-RT-LAMP assay detected YMV in leaf and tuber tissues of infected plants. The assay is 100 times more sensitive in detecting YMV than standard RT-PCR, while maintaining the same specificity...
January 8, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29307090/enemies-with-benefits-mutualistic-interactions-of-viruses-with-lower-eukaryotes
#13
REVIEW
Shounak S Jagdale, Rakesh S Joshi
Viruses represent some of the deadliest pathogens known to science. Recently they have been reported to have mutualistic interactions with their hosts, providing them direct or indirect benefits. The mutualism and symbiogenesis of such viruses with lower eukaryotic partners such as fungi, yeast, and insects have been reported but the full mechanism of interaction often remains an enigma. In many instances, these viral interactions provide resistance against several biotic and abiotic stresses, which could be the prime reason for the ecological success and positive selection of the hosts...
January 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29307089/genetic-and-biological-characterization-of-three-poultry-origin-h5n6-avian-influenza-viruses-with-all-internal-genes-from-genotype-s-h9n2-viruses
#14
Kaituo Liu, Min Gu, Shunlin Hu, Ruyi Gao, Juan Li, Liwei Shi, Wenqi Sun, Dong Liu, Zhao Gao, Xiulong Xu, Jiao Hu, Xiaoquan Wang, Xiaowen Liu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu
During surveillance for avian influenza viruses, three H5N6 viruses were isolated in chickens obtained from live bird markets in eastern China, between January 2015 and April 2016. Sequence analysis revealed a high genomic homology between these poultry isolates and recent human H5N6 variants whose internal genes were derived from genotype S H9N2 avian influenza viruses. Glycan binding assays revealed that all avian H5N6 viruses were capable of binding to both human-type SAα-2,6Gal receptors and avian-type SAα-2,3Gal receptors...
January 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29307088/physiological-traits-of-endornavirus-infected-and-endornavirus-free-common-bean-phaseolus-vulgaris-cv-black-turtle-soup
#15
S Khankhum, R A Valverde
This study evaluated the physiological traits of eight lines of common bean (Phaseolus vulgaris) cv. Black Turtle Soup, four of which were double-infected with Phaseolus vulgaris endornavirus 1 and Phaseolus vulgaris endornavirus 2, and four of which were endornavirus-free. Plants from all eight lines were morphologically similar and did not show statistically significant differences in plant height, wet weight, number of days to flowering and pod formation, pods per plant, pod thickness, seed size, number of seeds per pod, and anthocyanin content...
January 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29305646/genetic-and-immunogenicity-analysis-of-porcine-circovirus-type-2-strains-isolated-in-central-china
#16
Chang Liu, Yunchao Liu, Hongying Chen, Hua Feng, Yumei Chen, Yinbiao Wang, Juan Wang, Dongmin Liu, Ruiguang Deng, Gaiping Zhang
Porcine circovirus type 2 (PCV2) is an economically important pathogen in domestic pigs and wild boars all around the world. To understand the molecular epidemiology of PCV2 strains circulating in central China and to provide a potential vaccine candidate strain, we analyzed the genetic variations of 46 PCV2 isolates circulating from 2009 to 2016 in Henan Province (24 detected in the field from 2009-2013 and 22 from 2013-2016) and evaluated the efficacy of an isolate as a vaccine candidate strain in a mouse model...
January 5, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29302793/complete-genomic-sequence-of-raphanus-sativus-cryptic-virus-4-rscv4-a-novel-alphapartitivirus-from-radish
#17
Laurence Svanella-Dumas, Sébastien Theil, Matthieu Barret, Thierry Candresse
The present work reports the discovery and complete genome sequencing of a virus from symptomless radish seedlings, classifiable as a novel member of the genus Alphapartitivirus, family Partitiviridae. Total RNA extracted from germinating seedlings was sequenced using Illumina technology. Bioinformatic analysis of the RNA-seq data revealed two contigs representing the near full-length genomic sequences of two genomic RNAs representing a new virus. Analysis of the genome sequence (excluding the polyA tail, RNA1: 1976 nt and RNA2: 1751 nt, respectively) showed a genomic organization typical of viruses classed within the Partitiviridae, with each genomic RNA encoding a single open reading frame (ORF)...
January 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29302792/mitochondrial-bioenergy-alterations-in-avian-hd11-macrophages-infected-with-infectious-bronchitis-virus
#18
Sergio E L da Silva, Helena L Ferreira, Andrea F Garcia, Felipe E S Silva, Roberto Gameiro, Carolina U F Fabri, Dielson S Vieira, Tereza C Cardoso
To establish an association between mitochondrial dysfunction and apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results show that the M41 strain of IBV induced cytopathic effects followed by the release of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48 and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial membrane depolarization and reactive oxygen species (ROS) production at all of the examined timepoints p...
January 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29302791/molecular-characterization-of-a-putative-gammapartitivirus-in-the-phytopathogenic-fungus-nigrospora-oryzae
#19
Jin Xiu Yu, Jun Zi Zhu, Ying Wang, Chao Jun Zhang, Jie Zhong, Hong Jian Zhu, Bi Da Gao, Qian Zhou
We report the molecular attributes of a novel bisegmented double-stranded RNA (dsRNA) virus, designated "Nigrospora oryzae partitivirus 1" (NoPV1), from a phytopathogenic fungus Nigrospora oryzae. The genome of NoPV1 contains two dsRNA segments (dsRNA1 and 2), 1875 bp and 1601 bp in length, respectively. dsRNA1 and -2 both have a single open reading frame encoding the RNA-dependent RNA polymerase and coat protein, respectively. NoPV1 has a high degree of sequence identity to members of genus Gammapartitivirus in the family Partitiviridae...
January 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29299683/hpv-genotypes-detected-by-linear-array-and-next-generation-sequencing-in-anal-samples-from-hiv-positive-men-who-have-sex-with-men-in-mexico
#20
Luz A González-Hernández, María G Flores-Miramontes, Adriana Aguilar-Lemarroy, Krissya S Quintanilla-Peña, Fabiola L Martin-Amaya-Barajas, Moisés Ramos-Solano, Luis F Enciso Gómez, Jaime F Andrade-Villanueva, Luis F Jave-Suárez
The incidence of anal cancer has been rising, especially in HIV+ patients and has been associated with HPV infection. HIV+ patients are more at risk of HPV coinfection and are seven times more likely to have persistent HPV infection; moreover, HIV+ men have an increased risk of developing anal cancer compared to HIV+ women. The development of screening strategies for the detection of HPV in HIV+ men is of major importance; however, there is not enough information about the HPV genotypes and variants that are colonizing the anal epithelia of HIV+ men in diverse geographical regions...
January 3, 2018: Archives of Virology
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