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Archives of Virology

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https://www.readbyqxmd.com/read/29159591/evaluation-of-the-associations-between-endothelial-dysfunction-inflammation-and-coagulation-in-crimean-congo-hemorrhagic-fever-patients
#1
Halef Okan Doğan, Seyit Ali Büyüktuna, Sercan Kapancik, Sevtap Bakir
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease. The aim of this study was to evaluate the association between inflammation, coagulation and endothelial dysfunction in CCHF. The study population consisted of 40 patients and 50 healthy controls. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), endocan, high sensitive C-reactive protein (hsCRP), international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelets values were determined in blood samples...
November 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29159590/nanovirus-alphasatellite-complex-identified-in-vicia-cracca-in-the-rh%C3%A3-ne-delta-region-of-france
#2
Romain Gallet, Simona Kraberger, Denis Filloux, Serge Galzi, Hugo Fontes, Darren P Martin, Arvind Varsani, Philippe Roumagnac
Nanoviruses are multi-component plant-infecting single-stranded DNA viruses. Using a viral metagenomics-informed approach, a new nanovirus and two associated alphasatellite molecules have been identified in an uncultivated asymptomatic Vicia cracca plant in the Rhône region of France. This novel nanovirus genome includes eight genomic components (named DNA-R, DNA-S, DNA-M, DNA-C, DNA-N, DNA-U1, DNA-U2 and DNA-U4) and, across all components, shares < 66% pairwise sequence identity with other nanovirus genomes...
November 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29149435/equine-herpesvirus-type-1-orf51-encoding-ul11-as-an-essential-gene-for-replication-in-cultured-cells
#3
Yassien Badr, Ayaka Okada, Rania Abo-Sakaya, Emad Beshir, Kenji Ohya, Hideto Fukushi
Equine herpesvirus type 1 (EHV-1) UL11 is a 74-amino-acid tegument protein encoded by ORF51 of the EHV-1 genome. EHV-1 UL11 was previously reported by other researchers using the RacL22 and RacH strains to be nonessential for viral replication in cultured cells. Here, we constructed UL11 mutant viruses including a UL11 null mutant and three C-terminal truncated mutants, for further characterization of EHV-1 UL11 using bacterial artificial chromosome (BAC) technology based on the neuropathogenic strain Ab4p...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29149434/enhancement-of-therapeutic-dna-vaccine-potency-by-melatonin-through-inhibiting-vegf-expression-and-induction-of-antitumor-immunity-mediated-by-cd8-t-cells
#4
Sanaz Baghban Rahimi, Alireza Mohebbi, Gelareh Vakilzadeh, Peyvand Biglari, Soodeh Razeghi Jahromi, Seyed Reza Mohebi, Sadegh Shirian, Ali Gorji, Amir Ghaemi
To be effective, therapeutic cancer vaccines should stimulate both an effective cell-mediated and a robust cytotoxic CD8+ T-cell response against human papillomavirus (HPV)-infected cells to treat the pre-existing tumors and prevent potential future tumors. In this study, the therapeutic experiments were designed in order to evaluate antitumor effect against the syngeneic TC-1 tumor model. The anti-tumor efficacy of a HPV-16 E7 DNA vaccine adjuvanted with melatonin (MLT) was evaluated in a C57BL/6 mouse tumor model by measuring tumor growth post vaccination and the survival rate of tumor-bearing mice, analyzing the specific lymphocyte proliferation responses in control and vaccinated mice by MTT assay...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29147784/molecular-characterization-of-faba-bean-necrotic-yellows-viruses-in-tunisia
#5
Simona Kraberger, Safaa G Kumari, Asma Najar, Daisy Stainton, Darren P Martin, Arvind Varsani
Faba bean necrotic yellows virus (FBNYV) (genus Nanovirus; family Nanoviridae) has a genome comprising eight individually encapsidated circular single-stranded DNA components. It has frequently been found infecting faba bean (Vicia faba L.) and chickpea (Cicer arietinum L.) in association with satellite molecules (alphasatellites). Genome sequences of FBNYV from Azerbaijan, Egypt, Iran, Morocco, Spain and Syria have been determined previously and we now report the first five genome sequences of FBNYV and associated alphasatellites from faba bean sampled in Tunisia...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29147783/new-virus-of-the-family-flaviviridae-detected-in-lumpfish-cyclopterus-lumpus
#6
Renate Hvidsten Skoge, Jarle Brattespe, Arnfinn Lodden Økland, Heidrun Plarre, Are Nylund
In this study, we determined the complete coding sequence of a putative new member of the family Flaviviridae, named "Cyclopterus lumpus virus" (CLuV), which is associated with a serious disease in lumpfish (Cyclopterus lumpus). The virus was present in all tissues tested, but pathology was primarily observed in the liver and kidneys. CLuV shows low but distinct similarity to the unassigned Tamana bat virus (TABV). Unlike other known members of the family Flaviviridae, translation of the entire CLuV polyprotein is dependent on a - 1 ribosomal frameshift in the NS2A region...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29147793/pharmacophoric-characteristics-of-dengue-virus-ns2b-ns3pro-inhibitors-a-systematic-review-of-the-most-promising-compounds
#7
REVIEW
Camyla Alves Leonel, William Gustavo Lima, Michelli Dos Santos, Ariane Coelho Ferraz, Alex Gutterres Taranto, José Carlos de Magalhães, Luciana Lara Dos Santos, Jaqueline Maria Siqueira Ferreira
Dengue virus (DENV) infection can lead to a wide range of clinical manifestations, including fatal hemorrhagic complications. There is a need to find effective pharmacotherapies to treat this disease due to the lack of specific immunotherapies and antiviral drugs. That said, the DENV NS2B/NS3pro protease complex is essential in both the viral multiplication cycle and in disease pathogenesis, and is considered a promising target for new antiviral therapies. Here, we performed a systematic review to evaluate the pharmacophoric characteristics of promising compounds against NS2B/NS3pro reported in the past 10 years...
November 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29147792/characterization-of-a-novel-single-stranded-rna-mycovirus-related-to-invertebrate-viruses-from-the-plant-pathogen-verticillium-dahliae
#8
M Carmen Cañizares, Francisco J López-Escudero, Encarnación Pérez-Artés, María D García-Pedrajas
Fungal viruses, also known as mycoviruses, are widespread in all major groups of fungi. Mycoviruses from plant pathogens can reduce the virulence of their host fungus and have therefore potential as biological control agents. This has spurred the identification of novel mycoviruses in plant pathogens, research which is greatly contributing to our understanding of these organisms. In this work, we report the characterization of a novel monopartite mycovirus from Verticillium dahliae, the main causal agent of Verticillium wilt...
November 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29147791/completed-sequence-and-corrected-annotation-of-the-genome-of-maize-iranian-mosaic-virus
#9
Abozar Ghorbani, Keramatollah Izadpanah, Ralf G Dietzgen
Maize Iranian mosaic virus (MIMV) is a negative-sense single-stranded RNA virus that is classified in the genus Nucleorhabdovirus, family Rhabdoviridae. The MIMV genome contains six open reading frames (ORFs) that encode in 3΄ to 5΄ order the nucleocapsid protein (N), phosphoprotein (P), putative movement protein (P3), matrix protein (M), glycoprotein (G) and RNA-dependent RNA polymerase (L). In this study, we determined the first complete genome sequence of MIMV using Illumina RNA-Seq and 3'/5' RACE. MIMV genome ('Fars' isolate) is 12,426 nucleotides in length...
November 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29143142/prevalence-of-ns5b-resistance-associated-variants-in-treatment-na%C3%A3-ve-asian-patients-with-chronic-hepatitis-c
#10
Song Yang, Huichun Xing, Shenghu Feng, Wei Ju, Shunai Liu, Xiaomei Wang, Weini Ou, Jun Cheng, Calvin Q Pan
There is little information on the association between baseline non-structural protein (NS) 5b resistance-associated variants (RAVs) and treatment failure in hepatitis C patients. This study examined the frequencies of natural hepatitis C virus (HCV) NS5B resistance-associated variants (RAVs) in an Asian cohort. Samples from Asian HCV patients enrolled between October 2009 and September 2014 were analyzed for NS5B RAVs within the region from amino acid 230 to 371. Serum samples were tested by PCR genotyping, with sequence alignment performed using the neighbor-joining method...
November 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29143141/prevalence-and-genomic-characteristics-of-canine-kobuvirus-in-southwest-china
#11
Mingxiang Li, Nan Yan, Min Wang, Bin Zhang, Hua Yue, Cheng Tang
To investigate canine kobuvirus (CaKoV) infection in southwest China, 107 fecal samples were collected from dogs with obvious diarrhea in Sichuan and Chongqing regions, China. CaKoV infection was detected in 54 diarrheic samples (50.46%) by RT-PCR targeting a partial fragment (504 bp) of the 3D gene. Comparison of these partial 3D gene sequences from 14 of these CaKoV-positive samples show 95.4%-99.0% nucleotide (nt) identity within this group, and nt identities ranging from 93.1% to 98.2% with previously reported CaKoV 3D gene sequences...
November 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134340/rapid-visual-detection-of-lily-mottle-virus-using-a-loop-mediated-isothermal-amplification-method
#12
Binan Zhao, Dan Yang, Yongchun Zhang, Yan Xu, Xiao Zhao, Jieling Liang, Xiaorui Fan, Yanan Du, Ziping Zhu, Bin Shi, Qi Zhang, Xiaoxia Zhang, Youming Cai, Kai Zhao
Lily mottle virus (LMoV; genus Potyvirus, family Potyviridae) infects plants of the genus Lilium, causing a reduction in flower and bulb quality. A rapid and sensitive loop-mediated isothermal amplification (LAMP) assay was developed to detect the coat protein gene of LMoV. This LAMP method was highly specific for LMoV, with no cross-reaction with other lily viruses. The sensitivity of LMoV using the LAMP assay was 100 times more sensitive than that using conventional polymerase chain reaction. A reverse transcription LAMP (RT-LAMP) was then successfully applied to detect LMoV RNA...
November 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134339/feline-immudeficiency-virus-subtypes-b-and-a-in-cats-from-s%C3%A3-o-luis-maranh%C3%A3-o-brazil
#13
Nathálya Dos S Martins, Ana Paula de S Rodrigues, Luciana A da Luz, Luana da L Dos Reis, Renata M de Oliveira, Rudson A de Oliveira, Ana Lucia Abreu-Silva, Jenner Karlisson P Dos Reis, Ferdinan A Melo
Feline immunodeficiency virus (FIV) is a retrovirus of the genus Lentivirus that is distributed worldwide, with prevalence rates varying between 2.5% and 44%. FIV causes immunosuppression, with depletion of TCD4(+) lymphocytes, with the majority of clinical signs caused by secondary and opportunistic infections. Blood samples were collected from nine domestic cats (Felis catus domesticus) from the city of São Luís, Maranhão State, Brazil. All samples were positive in a rapid immunochromatographic test (SNAP® Combo FeLV Ag/FIV Antibody Test) and in a polymerase chain reaction (PCR) assay...
November 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134338/molecular-characterization-of-a-novel-luteovirus-infecting-apple-by-next-generation-sequencing
#14
Pan Shen, Xin Tian, Song Zhang, Fang Ren, Ping Li, Yun-Qi Yu, Ruhui Li, Changyong Zhou, Mengji Cao
A new single-stranded positive-sense RNA virus, which shares the highest nucleotide (nt) sequence identity of 53.4% with the genome sequence of cherry-associated luteovirus South Korean isolate (ChALV-SK, genus Luteovirus), was discovered in this work. It is provisionally named apple-associated luteovirus (AaLV). The complete genome sequence of AaLV comprises 5,890 nt and contains eight open reading frames (ORFs), in a very similar arrangement that is typical of members of the genus Luteovirus. When compared with other members of the family Luteoviridae, ORF1 of AaLV was found to encompass another ORF, ORF1a, which encodes a putative 32...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134337/recombination-analysis-of-coxsackievirus-b5-genogroup-c
#15
Hongxing Shen
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134336/complete-genome-sequence-of-a-new-member-of-the-genus-badnavirus-dioscorea-bacilliform-rt-virus-3-reveals-the-first-evidence-of-recombination-in-yam-badnaviruses
#16
Moritz Bömer, Ajith I Rathnayake, Paul Visendi, Gonçalo Silva, Susan E Seal
Yams (Dioscorea spp.) host a diverse range of badnaviruses (genus Badnavirus, family Caulimoviridae). The first complete genome sequence of Dioscorea bacilliform RT virus 3 (DBRTV3), which belongs to the monophyletic species group K5, is described. This virus is most closely related to Dioscorea bacilliform SN virus (DBSNV, group K4) based on a comparison of genome sequences. Recombination analysis identified a unique recombination event in DBRTV3, with DBSNV likely to be the major parent and Dioscorea bacilliform AL virus (DBALV) the minor parent, providing the first evidence for recombination in yam badnaviruses...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29134335/quantitative-analysis-of-senecavirus-a-in-tissue-samples-from-naturally-infected-newborn-piglets
#17
Alais Maria Dall Agnol, Flavia Megumi Miyabe, Raquel Arruda Leme, Thalita Evani Silva Oliveira, Selwyn Arlington Headley, Amauri Alcindo Alfieri, Alice Fernandes Alfieri
In this study, we determined the distribution of senecavirus A (SVA) and viral RNA load in different organs and tissues of naturally infected piglets. A TaqMan-based qRT-PCR assay was performed using RNA extracted from brainstem, cerebellum, cerebrum, heart, kidney, liver, lungs, small intestine, spleen, urinary bladder, and tonsils of seven newborn piglets. SVA was detected in 57 out of 70 tissue samples (81.4%). Viral loads ranged from 4.07 to 10.38 log10 genomic copies per g of tissue. The results show that SVA has tropism for various organs in naturally infected newborn piglets, especially for tonsils, spleen, lungs, and liver...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29129019/genetic-characterization-of-bank-vole-virus-bavv-a-new-paramyxovirus-isolated-from-kidneys-of-bank-voles-in-russia
#18
Sergey Alkhovsky, Alexander Butenko, Aykaz Eremyan, Alexey Shchetinin
A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV...
November 11, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29127489/genetic-characterization-of-the-complete-genome-of-a-mutant-canine-parvovirus-isolated-in-china
#19
Chuanfeng Li, Jingyu Tang, Zongyan Chen, Qi Li, Zhenhua Huang, Quan Wang, Chunchun Meng, Yong Wang, Guangqing Liu
A field canine parvovirus (CPV) strain, CPV-SH14, was previously isolated from an outbreak of severe gastroenteritis in Shanghai in 2014. The complete genome of CPV-SH14 was determined by using PCR with modified primers. When compared to other CPV-2 strains, several insertions, deletions, and point mutations were identified in the 5' and 3' UTR, with key amino acid (aa) mutations (K19R, E572K in NS1 and F267Y, Y324I and T440A in VP2) also being observed in the coding regions of CPV-SH14. These results indicated that significant and unique genetic variations have occurred at key sites or residues in the genome of CPV-SH14, suggesting the presence of a novel genetic variant of new CPV-2a...
November 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29119360/optimization-of-a-magnetic-capture-rt-lamp-assay-for-fast-and-real-time-detection-of-potato-virus-y-and-differentiation-of-n-and-o-serotypes
#20
Krzysztof Treder, Joanna Chołuj, Bogumiła Zacharzewska, Lavanya Babujee, Mateusz Mielczarek, Adam Burzyński, Aurélie M Rakotondrafara
Potato virus Y (PVY) infection has been a global challenge for potato production and the leading cause of downgrading and rejection of seed crops for certification. Accurate and timely diagnosis is a key for effective disease control. Here, we have optimized a reverse transcription loop-mediated amplification (RT-LAMP) assay to differentiate the PVY O and N serotypes. The RT-LAMP assay is based on isothermal autocyclic strand displacement during DNA synthesis. The high specificity of this method relies heavily on the primer sets designed for the amplification of the targeted regions...
November 8, 2017: Archives of Virology
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