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Archives of Virology

Ibukun A Akinyemi, Fang Wang, Zhao-Xia Chang, Qingfa Wu
Maize-associated totivirus Anhui (MATV-Ah) is a novel totivirus with a 5536-nt genome and two large ORFs that encode a putative coat protein (CP) and an RNA-dependent RNA polymerase (RdRP). The two ORFs share amino acid identities of 32 and 56% when compared to other plant-associated totiviruses, respectively. Based on genome sequence similarity and phylogenetic analysis, MATV-Ah is proposed to be a member of the family Totiviridae genus Totivirus.
July 18, 2018: Archives of Virology
Seyed Mohammad Javad Hosseini, Seyed Mohsen Mirhosseini, Mehdi Taghian, Mehrdad Salehi, Maryam Moshkani Farahani, Fariba Bakhtiari, Masoumeh Ghasemi-Pirbaluti, Ehsan Motaghi
Previous studies have detected adenovirus and cytomegalovirus (CMV) in cardiac tissue of patients with myocarditis. Therefore, in this study, we investigated the frequency of these viruses, which may be involved in the development of severe dilated cardiomyopathy (DCM). Myocardial tissue from of 23 cardiac transplant candidates with acute idiopathic DCM below the age of 40 years were analyzed by amplification of adenovirus and CMV DNA and subsequent sequencing. Adenovirus was detected in four (17.4%) and CMV in one (4...
July 18, 2018: Archives of Virology
Ting-Kai Chang, Yuh-Kun Chen
Plants of the species Gomphocarpus physocarpus, commonly known as balloon plant or swan plant, exhibiting virus-like symptoms of mosaic, mottle and crinkling were observed and collected in the southwestern part of Taiwan in 2015. Electron microscopic examination showed the presence of virus-like flexuous-rod particles. Potyvirus pinwheel-shape and laminated inclusion bodies were observed in the preparations of ultrathin sections of diseased leaves. The complete genome sequence of the potyvirus of balloon plant was determined...
July 12, 2018: Archives of Virology
Charles H Calisher
No abstract text is available yet for this article.
July 11, 2018: Archives of Virology
Mohamed Hassan, Muhammad S Shahid, Ioannis E Tzanetakis
Blackberries exhibiting yellow vein disease symptoms were found to be infected by a new virus, a putative member of the genus Vitivirus. Recombination assessment of several vitiviruses revealed multiple events involving the newly identified virus isolate. Occurrence in areas of high disease pressure was investigated and the population structure was studied using the movement and coat protein genes; both under purifying selection. This information was exploited in the development of a detection protocol for routine screening and Rubus certification programs around the globe...
July 9, 2018: Archives of Virology
Supinya Phakaratsakul, Thanyaporn Sirihongthong, Chompunuch Boonarkart, Ornpreya Suptawiwat, Prasert Auewarakul
RNA viruses are classified by their genome polarity and replication strategies. Nucleotide composition and codon usage differ among virus groups, for instance positive-sense RNA (+ssRNA) viruses have higher GC-content than the other RNA virus groups. Codon usage of +ssRNA viruses is closer to humans showing significantly higher codon adaptation index (CAI) than those of negative-sense RNA (-ssRNA), double stranded RNA (dsRNA) and retroviruses. Ambisense viruses have high CAI comparable to that of +ssRNA virus despite their lower GC content, whereas dsRNA viruses have the lowest CAI...
July 9, 2018: Archives of Virology
Ning Shi, Hao Liu, Li-Xia Li, Bo Hu, Lei Zhang, Chuan-Fang Zhao, Xiao-Yu Deng, Xin-Tong Li, Xiang-Hong Xue, Xue Bai, Hai-Ling Zhang, Rong-Guang Lu, Shi-Zhen Lian, Yang Wang, Ming-Hao Yan, Xi-Jun Yan
Getah virus (GETV), a mosquito-borne virus that mainly infects horses and pigs, has emerged and spread in China. We developed a highly specific and reproducible TaqMan probe-based quantitative reverse transcription PCR (RT-qPCR) assay targeting the non-structural protein 1 of GETV, whose detection limit is 25.5 copies/µL, which is 100-fold higher than that of conventional RT-PCR. RT-qPCR was used to detect GETV RNA in mosquito and animal clinical samples, showing that the accuracy of RT-qPCR was higher than that of conventional RT-PCR...
July 9, 2018: Archives of Virology
Karin F L P Fontes, Luiz C Silva-Júnior, Sérgio A Nascimento, Daniel P Chaves, Jose W Pinheiro-Júnior, Antonio C Freitas, Roberto S Castro, André L S Jesus
A codon-optimized equine infectious anemia virus p26 gene was fused to a maltose-binding protein (MBP) and expressed in Escherichia coli for use as an antigen in agar gel immunodiffusion (AGID) and enzyme-linked immunosorbent assay (ELISA) for diagnosis of equine infectious anemia. An analysis of analytical sensitivity and specificity showed that the antigen MBP-p26rec reacted positively with a reference World Organization for Animal Health serum and demonstrated no cross-reaction against sera from vaccinated animals in either test...
July 7, 2018: Archives of Virology
Meiling Jin, Xiaoyan Wang, Kang Ning, Ning Liu, Dabing Zhang
Since early 2016, the Chinese goose industry has experienced severe outbreaks of gout; however, the etiological factor of the disease is still unclear. Here, we investigated the possible involvement of viral infection in the disease. Using sequence-independent PCR amplification, astrovirus sequences were generated from a gout case. Full-length genomic sequencing and sequence analysis of three goose astrovirus (GoAstV) strains revealed that they belong to a new avastrovirus most closely related to viruses classified within species Avastrovirus 3...
July 6, 2018: Archives of Virology
Evelyne Lemaitre, Françoise Zwingelstein, Stéphane Marchandeau, Ghislaine Le Gall-Reculé
We report the full genome sequence of the non-pathogenic rabbit lagovirus Lagovirus europaeus/GI.3/O cun/FR/2006/06-11 (GI.3/06-11), collected from a healthy French domestic rabbit in 2006, and initially described as 06-11 strain. The sequence reveals a genomic organization similar to lagoviruses. It was 7,436 bases long and contained two open reading frames (ORF). A dipeptide variation at the potential p23/2C-like helicase cleavage site (EE instead of ED) was observed, a feature only shared with non-recombinant pathogenic lagoviruses in GI...
July 5, 2018: Archives of Virology
Zhao Gao, Jiao Hu, Xiaoquan Wang, Qian Yang, Yanyan Liang, Chunxi Ma, Dong Liu, Kaituo Liu, Xiaoli Hao, Min Gu, Xiaowen Liu, Xin-An Jiao, Xiufan Liu
Polymerase acidic (PA) protein is a multifunctional regulator of influenza A virus (IAV) replication and pathogenesis. In a previous study, we reported that nucleolin (NCL) is a novel PA-interacting host protein. In this study, we further explored the role of NCL during highly pathogenic H5N1 avian influenza virus infection. We found that depletion of endogenous NCL in mammalian cells by siRNA targeting during H5N1 infection resulted in significantly increased viral polymerase activity, elevated viral mRNA, cRNA and vRNA synthesis, accelerated viral replication, and enhanced apoptosis and necrosis...
July 5, 2018: Archives of Virology
Mohamed Darwish Ahmed Abd Alla, Mostafa Kamel El Awady, Reham M Dawood, Mostafa Abdelaziz Elhawary, Shabaan Salah Al-Azhari, Al-Shazly Gaber Mohamed Galal
The disappearance of hepatitis C virus (HCV) from serum and tissues for 12 weeks after the end of treatment (EOT) with direct-acting antivirals (DAAs) is known as a "sustained virologic response" (SVR) and occurs more frequently in non-cirrhotic patients than in cirrhotic patients. In this study, we evaluated the outcome of HCV treatment with sofosbuvir (SOF) plus ledipasvir (LDV) at both EOT and 12 weeks after EOT in patients with and without hepatic cirrhosis to address the relationship of serologic relapse to persistent infection of PBMCs and the frequency of hepatic encephalopathy and hepatocellular carcinoma (HCC) after treatment...
July 3, 2018: Archives of Virology
Chenghuai Yang, Leyi Wang, Huigang Shen, Ying Zheng, Phillip C Gauger, Qi Chen, Jianqiang Zhang, Kyoung-Jin Yoon, Karen M Harmon, Rodger G Main, Ganwu Li
Hepatitis E virus (HEV) is a nonenveloped, positive-sense, single-stranded RNA virus that has been detected in a wide variety of animals. In 2017, an avian-like HEV was identified in sparrow feces sampled from around a pig farm in the midwestern United States. Sequence analysis revealed that the sparrow isolate represents a novel HEV that is distantly related to chicken and little egret HEVs.
July 3, 2018: Archives of Virology
Wahid H El-Dabae, Hussein Aly Hussein, Mohammed A Rohaim, Munir M El-Safty, Nagwa S Ata, Ismail M Reda
Despite extensive vaccination campaigns, Newcastle disease virus (NDV) remains endemic in many countries worldwide, and factors that contribute to this failure include mismatched vaccines, partial immunization, and poor husbandry practices. In order to overcome the problem of genetic divergence between circulating field strains and vaccine strains, we saponin-adjuvanted an Egyptian field strain and assessed its safety and immunogenicity in chickens. Immunization of chickens with the vaccine followed by challenge with a velogenic reference strain revealed the potential of the saponin-adjuvanted vaccine to induce a strong immune response that resulted in complete protection of chickens...
July 2, 2018: Archives of Virology
Dan Zhang, Haiyan Mao, Xiuyu Lou, Junhang Pan, Hao Yan, Hongfeng Tang, Yan Shu, Yun Zhao, Xiaoli Cheng, Hong Tao, Yanjun Zhang, Xuejun Ma
We developed a panel of multiplex quantitative real-time reverse transcription polymerase chain reaction (mqRT-PCR) assay consisting of seven internally controlled qRT-PCR assays to detect 16 different respiratory viruses. We compared the new mqRT-PCR with a previously reported two-tube mRT-PCR assay using 363 clinical sputum specimens. The mqRT-PCR assay performed comparably with the two-tube assay for most viruses, offering the advantages of quantitative analysis, easier performance, lower susceptibility to contamination, and shorter turnaround time in laboratories equipped with conventional real-time PCR instrumentation, and it could therefore be a valuable tool for routine surveillance of respiratory virus infections in China...
June 30, 2018: Archives of Virology
Regina Célia Moreira, Ana Paula de Torres Santos, Gaspar Lisboa-Neto, Maria Cássia Jacintho Mendes-Corrêa, Marcilio Figueiredo Lemos, Fernanda Mello Malta, Rúbia Anita Ferraz Santana, Gregório Tadeu Fernando Dastoli, Vanessa Fusco Duarte de Castro, João Renato Rebello Pinho
Hepatitis C (HCV)-infected patients are treated with direct-acting antiviral agents (DAAs) in highly effective, well-tolerated, all-oral regimens. However, naturally occurring resistance-associated amino acid substitutions (RASs) may be selected during treatment. This study aimed to screen naturally occurring RASs NS3/NS4A inhibitors (PIs). Samples were obtained from DAA naïve patients, living in São Paulo state, Brazil. Screening for RASs in the HCV NS3 region was conducted in 859 samples from HCV-infected patients, of which 425 and 434 samples were subtype 1a and 1b, respectively...
June 30, 2018: Archives of Virology
Myoung-Jin Kim, Seongdo Lee, G I Godahewa, Jee Youn Hwang, Jung Soo Seo, Seong Don Hwang, Jehee Lee
Spring viremia of carp (SVC) is listed as a notifiable viral disease by the World Organization for Animal Health (OIE). In 2016, the first official SVC outbreak was detected in the city of Gyeongsan, Korea. The present study reports the first complete genome analysis of SVC virus (SVCV, ADC-SVC2016-5) isolated from leather carp (Cyprinus carpio nudus). The results revealed that ADC-SVC2016-5 has a 11,029-bp genome containing five genes: N, P, M, G, and L. Phylogenetic analysis indicated that ADC-SVC2016-5 (accession number MG663512), isolated from leather carp, was closely related to genogroup Ia isolates of the Asian clade...
June 26, 2018: Archives of Virology
Alexander E Gorbalenya
This opinion article makes a case for increasing the number of ranks used in virus taxonomy from the current five to ten (as are used to classify cellular life forms) and placing the Baltimore classes in the proposed basal rank of domain. These suggestions aim at initiating the process of accommodation of Baltimore classes in virus taxonomy and extension of the virus taxonomy scale to encompass also the most distant relationships.
June 26, 2018: Archives of Virology
Hosni A M Hussein, Ikenna B Okafor, Lia R Walker, Usama M Abdel-Raouf, Shaw M Akula
Oncogenic viruses carry an extensive arsenal of oncogenes for hijacking cellular pathways. Notably, variations in oncogenes among tumor-producing viruses give rise to different mechanisms for cellular transformation. Specifically, Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus able to infect and transform a variety of cell types. The oncogenicity of KSHV disseminates from the virus' ability to induce and encode a wide variety of both cellular and viral oncogenes. Such an array of cellular and viral oncogenes enables KSHV to induce the malignant phenotype of a KSHV-associated cancer...
June 23, 2018: Archives of Virology
Felipe Gonçalves Motta Maia, William Marciel de Souza, Gilberto Sabino-Santos, Marcílio Jorge Fumagalli, Sejal Modha, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo
The nearly complete genome sequence of a novel polyomavirus from blood samples of Akodon montensis and Calomys tener collected in Brazil was determined by high-throughput sequencing. This virus showed a typical polyomaviruses genome organization, and it was classified as a member of the genus Betapolyomavirus. Our results expand the host range and viral diversity of the family Polyomaviridae.
June 21, 2018: Archives of Virology
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