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Transactions of the American Ophthalmological Society

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https://www.readbyqxmd.com/read/29085257/evaluation-of-visual-field-and-imaging-outcomes-for-glaucoma-clinical-trials-an-american-ophthalomological-society-thesis
#1
David F Garway-Heath, Ana Quartilho, Philip Prah, David P Crabb, Qian Cheng, Haogang Zhu
PURPOSE: To evaluate the ability of various visual field (VF) analysis methods to discriminate treatment groups in glaucoma clinical trials and establish the value of time-domain optical coherence tomography (TD OCT) imaging as an additional outcome. METHODS: VFs and retinal nerve fibre layer thickness (RNFLT) measurements (acquired by TD OCT) from 373 glaucoma patients in the UK Glaucoma Treatment Study (UKGTS) at up to 11 scheduled visits over a 2 year interval formed the cohort to assess the sensitivity of progression analysis methods...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29021717/enhanced-detection-of-sub-retinal-pigment-epithelial-cell-layer-deposits-in-human-and-murine-tissue-imaging-zinc-as-a-biomarker-for-age-related-macular-degeneration-an-american-ophthalmological-society-thesis
#2
Frederik J G M van Kuijk, Scott W McPherson, Heidi Roehrich
PURPOSE: Understanding the apparent paradoxical role of zinc in the pathogenesis and prevention of age-related macular degeneration (AMD) has been limited by the lack of animal models for its detection in sub-retinal epithelial deposits (drusen), a definitive early hallmark of AMD. In-vitro studies using Zinpyr-1 showed drusen contained high levels of zinc, but the probe was not suitable for in-vivo studies. This study compares Zinpyr-1 to ZPP1, a new fluorescein-based probe for zinc, to assess the potential of ZPP1 for in-vivo detection of zinc in drusen...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29021716/continuous-curvilinear-capsulorhexis-training-and-non-rhexis-related-vitreous-loss-the-specificity-of-virtual-reality-simulator-surgical-training-an-american-ophthalmological-society-thesis
#3
Colin A McCannel
PURPOSE: To assess the specificity of simulation-based virtual reality ophthalmic cataract surgery training on the Eyesi ophthalmic virtual reality surgical simulator, and test the hypothesis that microsurgical motor learning is highly specific. METHODS: Retrospective educational interventional case series. The rates of vitreous loss and retained lens material, and vitreous loss and retained lens material associated with an errant continuous curvilinear capsulorhexis (CCC) were assessed among 1037 consecutive cataract surgeries performed during four consecutive academic years at a teaching hospital...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28900371/biochemical-measurements-of-free-opsin-in-macular-degeneration-eyes-examining-the-11-cis-retinal-deficiency-hypothesis-of-delayed-dark-adaptation-an-american-ophthalmological-society-thesis
#4
REVIEW
Anne Hanneken, Thomas Neikirk, Jennifer Johnson, Masahiro Kono
PURPOSE: To test the hypothesis that delayed dark adaptation in patients with macular degeneration is due to an excess of free unliganded opsin (apo-opsin) and a deficiency of the visual chromophore, 11-cis retinal, in rod outer segments. METHODS: A total of 50 human autopsy eyes were harvested from donors with and without macular degeneration within 2-24 hrs. postmortem. Protocols were developed which permitted dark adaptation of normal human eyes after death and enucleation...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28588345/neuroanatomic-variations-in-graves-dysthyroid-ophthalmopathy-as-studied-with-mri
#5
Rona Z Silkiss, Alex R Wade
PURPOSE: To evaluate whether patients with Graves' dysthyroid ophthalmopathy (GDO) have changes in brain anatomy that can be assessed by neuroimaging as compared to age-matched controls. METHODS: We examined 10 female, euthyroid patients with GDO and 14 age and gender matched controls using high-resolution structural MRI scanning. An automatic cortical segmentation algorithm was used to estimate the thickness of each subject's gray matter across the brain. The resulting cortical thickness measurements were transferred to a standard reference space via a template-based warping procedure...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28260821/erratum-the-hematologic-definition-of-monoclonal-gammopathy-of-undetermined-significance-in-relation-to-paraproteinemic-keratopathy-an-american-ophthalmological-society-thesis
#6
Walter Lisch, Joanna Wasielica-Poslednik, Tero Kivelä, Ursula Schlötzer-Schrehardt, Jens M Rohrbach, Walter Sekundo, Uwe Pleyer, Christina Lisch, Alexander Desuki, Heidi Rossmann, Jayne S Weiss
[This corrects the article on p. T7 in vol. 114, PMID: 28050052.].
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28050052/the-hematologic-definition-of-monoclonal-gammopathy-of-undetermined-significance-in-relation-to-paraproteinemic-keratopathy-an-american-ophthalmological-society-thesis
#7
Walter Lisch, Joanna Wasielica-Poslednik, Tero Kivelä, Ursula Schlötzer-Schrehardt, Jens M Rohrbach, Walter Sekundo, Uwe Pleyer, Christina Lisch, Alexander Desuki, Heidi Rossmann, Jayne S Weiss
PURPOSE: To determine if paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of undetermined significance (MGUS) causes distinct patterns of corneal opacification that can be distinguished from hereditary, immunologic, or inflammatory causes. METHODS: A retrospective, interventional study of patients showed distinct bilateral opacity patterns of the cornea at the eye clinics of Hanau, Mainz, Helsinki, Marburg, and Berlin between 1993 and 2015...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28050051/discordant-dry-eye-disease-an-american-ophthalmological-society-thesis
#8
Roni M Shtein, Daniel E Harper, Vincent Pallazola, Steven E Harte, Munira Hussain, Alan Sugar, David A Williams, Daniel J Clauw
PURPOSE: To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition. METHODS: Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28042184/the-palisades-of-vogt-in-congenital-corneal-opacification-an-american-ophthalmological-society-thesis
#9
Ken K Nischal, Kira L Lathrop
PURPOSE: The purposes of this study are first, to determine if the palisades of Vogt (POV) are present or absent in cases of congenital corneal opacification (CCO) by using spectral domain ocular coherence tomography (SD-OCT), and second, in those cases already undergoing penetrating keratoplasty (PKP), to see whether the absence or presence of POV corresponds to re-epithelialization following transplant. METHODS: This was a retrospective case review of 20 eyes (10 normal, 10 with CCO) evaluated with SD-OCT...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28018010/uveal-melanoma-cell-lines-where-do-they-come-from-an-american-ophthalmological-society-thesis
#10
REVIEW
Martine J Jager, J Antonio Bermudez Magner, Bruce R Ksander, Sander R Dubovy
PURPOSE: To determine whether some of the most often used uveal melanoma cell lines resemble their original tumor. METHODS: Analysis of the literature, patient charts, histopathology, mutations, chromosome status, HLA type, and expression of melanocyte markers on cell lines and their primary tumors. We examined five cell lines and the primary tumors from which they were derived. RESULTS: Four of the five examined primary tumors were unusual: one occupied the orbit, two were recurrences after prior irradiation, and one developed in an eye with a nevus of Ota...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28008209/paradigm-shifts-in-ophthalmic-diagnostics
#11
REVIEW
J Sebag, Alfredo A Sadun, Eric A Pierce
PURPOSE: Future advances in ophthalmology will see a paradigm shift in diagnostics from a focus on dysfunction and disease to better measures of psychophysical function and health. Practical methods to define genotypes will be increasingly important and non-invasive nanotechnologies are needed to detect molecular changes that predate histopathology. METHODS: This is not a review nor meant to be comprehensive. Specific topics have been selected to illustrate the principles of important paradigm shifts that will influence the future of ophthalmic diagnostics...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27881886/tank-binding-kinase-1-tbk1-gene-and-open-angle-glaucomas-an-american-ophthalmological-society-thesis
#12
John H Fingert, Alan L Robin, Todd E Scheetz, Young H Kwon, Jeffrey M Liebmann, Robert Ritch, Wallace L M Alward
PURPOSE: To investigate the role of TANK-binding kinase 1 (TBK1) gene copy-number variations (ie, gene duplications and triplications) in the pathophysiology of various open-angle glaucomas. METHODS: In previous studies, we discovered that copy-number variations in the TBK1 gene are associated with normal-tension glaucoma. Here, we investigated the prevalence of copy-number variations in cohorts of patients with other open-angle glaucomas-juvenile-onset open-angle glaucoma (n=30), pigmentary glaucoma (n=209), exfoliation glaucoma (n=225), and steroid-induced glaucoma (n=79)-using a quantitative polymerase chain reaction assay...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27630374/the-effect-of-different-dosing-schedules-of-intravitreal-sirolimus-a-mammalian-target-of-rapamycin-mtor-inhibitor-in-the-treatment-of-non-infectious-uveitis-an-american-ophthalmological-society-thesis
#13
RANDOMIZED CONTROLLED TRIAL
Quan Dong Nguyen, Mohammad Ali Sadiq, Mohamed Kamel Soliman, Aniruddha Agarwal, Diana V Do, Yasir J Sepah
PURPOSE: To determine if two different doses of intravitreal sirolimus, an mTOR inhibitor, can decrease inflammation and is safe in eyes with non-infectious posterior, intermediate, or panuveitis in the Sirolimus as a Therapeutic Approach UVEitis: Protocol-2 (SAVE-2) Study. METHODS: SAVE-2 is a prospective randomized, phase II, open-label interventional clinical trial conducted at 4 clinical centers in the United States. Eligible subjects were randomized into one of two treatments...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27630373/ranibizumab-for-the-prevention-of-radiation-complications-in-patients-treated-with-proton-beam-irradiation-for-choroidal-melanoma
#14
RANDOMIZED CONTROLLED TRIAL
Ivana K Kim, Anne Marie Lane, Purva Jain, Caroline Awh, Evangelos S Gragoudas
PURPOSE: To investigate the safety and potential efficacy of ranibizumab for prevention of radiation complications in patients treated with proton irradiation for choroidal melanoma. METHODS: Forty patients with tumors located within 2 disc diameters of the optic nerve and/or macula were enrolled in this open-label study. Participants received ranibizumab 0.5 mg or 1.0 mg at tumor localization and every 2 months thereafter for the study duration of 24 months. The incidence of adverse events, visual acuity, and other measures of ocular morbidity related to radiation complications were assessed...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27630372/a-large-scale-computational-analysis-of-corneal-structural-response-and-ectasia-risk-in-myopic-laser-refractive-surgery
#15
William Joseph Dupps, Ibrahim Seven
PURPOSE: To investigate biomechanical strain as a structural susceptibility metric for corneal ectasia in a large-scale computational trial. METHODS: A finite element modeling study was performed using retrospective Scheimpflug tomography data from 40 eyes of 40 patients. LASIK and PRK were simulated with varied myopic ablation profiles and flap thickness parameters across eyes from LASIK candidates, patients disqualified for LASIK, subjects with atypical topography, and keratoconus subjects in 280 simulations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27895380/the-age-related-macular-degeneration-complex-linking-epidemiology-and-histopathology-using-the-minnesota-grading-system-the-inaugural-frederick-c-blodi-lecture
#16
Timothy W Olsen, Alexander R Bottini, Pia Mendoza, Hans E Grossniklausk
PURPOSE: To describe the histopathologic findings of the four stages of age-related macular degeneration (AMD) as defined by the Age-Related Eye Disease Study (AREDS) using the Minnesota grading system (MGS). CLINICAL RELEVANCE: There are no animal models for AMD. Eye banks enable access to human tissue with AMD. The level of AMD (grades 1 through 4) as defined by AREDS is determined ex vivo using the MGS. The AREDS has the largest collection to date of prospectively gathered data on the natural history of AMD...
September 2015: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27507907/dry-eye-disease-incidence-associated-with-chronic-graft-host-disease-nonconcurrent-cohort-study-an-american-ophthalmological-society-thesis
#17
Shahzad I Mian, Paola De la Parra-Colín, Rafael De Melo-Franco, Christopher Johnson, Tonatiuh Barrientos-Gutierrez
PURPOSE: To determine if chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with stable or progressive dry eye disease and to determine the true incidence in patients with no prior history of dry eye disease. METHODS: A nonconcurrent cohort study at a single institution with 136 patients who had no previous history of dry eye disease before HSCT. Survival analysis was used to estimate dry eye disease incidence...
September 2015: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/26877563/ophthalmic-manifestations-of-amyotrophic-lateral-sclerosis-an-american-ophthalmological-society-thesis
#18
Nicholas J Volpe, Joseph Simonett, Amani A Fawzi, Teepu Siddique
PURPOSE: To determine if clinical and histopathologic findings were present in the eyes of patients with amyotrophic lateral sclerosis (ALS) and explore correlations to an animal model of ALS. METHODS: Two patients with ALS were studied histopathologically as well as the retinas of ALS/dementia transgenic mice with dysfunctional ubiquilin2, UBQLN2(P497H). Clinical study 1, an observational, cross-sectional study, was performed using optical coherence tomography (OCT) to obtain and compare mean total macular thickness and average and quadrant specific peripapillary retinal nerve fiber layer (pRNFL) scans from 16 patients with ALS to controls...
2015: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/26755855/long-term-outcome-of-half-dose-verteporfin-photodynamic-therapy-for-the-treatment-of-central-serous-chorioretinopathy-an-american-ophthalmological-society-thesis
#19
Timothy Y Y Lai, Raymond L M Wong, Wai-Man Chan
PURPOSE: To evaluate whether half-dose verteporfin photodynamic therapy (PDT) is better than natural history for the treatment of central serous chorioretinopathy (CSC). METHODS: Retrospective review of consecutive CSC patients treated with half-dose verteporfin PDT or untreated with observation and a minimum follow-up of 36 months. The main outcome measures included mean change in visual acuity and CSC recurrence. Survival analysis was performed to compare the CSC recurrence rates between the two groups...
2015: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/26755854/development-of-selective-lamellar-keratoplasty-within-an-asian-corneal-transplant-program-the-singapore-corneal-transplant-study-an-american-ophthalmological-society-thesis
#20
Donald Tan, Marcus Ang, Anshu Arundhati, Wei-Boon Khor
PURPOSE: To evaluate outcomes of anterior lamellar keratoplasty (ALK) and endothelial keratoplasty (EK) within the Singapore Corneal Transplant Study (SCTS), with the hypothesis that both ALK and EK are able to provide equivalent or improved clinical outcomes, compared to penetrating keratoplasty (PK), and to determine changing trends globally with other international databases. METHODS: Clinical data on all transplants performed was derived from our SCTS database, a prospective national keratoplasty registry, and clinical outcomes (graft survival, endothelial cell loss, complications, visual acuity) were compared between PK, ALK, and EK...
2015: Transactions of the American Ophthalmological Society
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