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Mycopathologia

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https://www.readbyqxmd.com/read/28447292/ecology-of-the-human-opportunistic-black-yeast-exophiala-dermatitidis-indicates-preference-for-human-made-habitats
#1
Monika Novak Babič, Jerneja Zupančič, Nina Gunde-Cimerman, Sybren de Hoog, Polona Zalar
Exophiala dermatitidis is an ascomycetous black yeast from the order Chaetothyriales. Its growth characteristics include the polymorphic life cycle, ability to grow at high and low temperatures, at a wide pH range, survival at high concentrations of NaCl, and survival at high UV and radioactive radiation. Exophiala dermatitidis causes deep or localized phaeohyphomycosis in immuno-compromised people worldwide and is regularly encountered in the lungs of cystic fibrosis patients. Regardless of numerous ecological studies worldwide, little is known about its natural habitat or the possible infection routes...
April 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28439794/the-effectiveness-of-voriconazole-in-therapy-of-candida-glabrata-s-biofilms-oral-infections-and-its-influence-on-the-matrix-composition-and-gene-expression
#2
Célia F Rodrigues, Bruna Gonçalves, Maria Elisa Rodrigues, Sónia Silva, Joana Azeredo, Mariana Henriques
Candida glabrata is one of most prevalent yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms. The main goal of this work was to study the effectiveness of voriconazole (Vcz) against C. glabrata biofilms oral pathologies, as esophageal or oropharyngeal candidiasis. Antifungal susceptibilities were determined in pre-formed 24-h-biofilms and ERG genes expression was determined by qRT-PCR. Protein quantification was performed using BCA(®) Kit, carbohydrate was estimated according to the Dubois assay and β-1,3 glucans concentration were determined using Glucatell(®) kit...
April 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28421452/susceptibility-of-candida-albicans-from-cystic-fibrosis-patients
#3
Raquel Sabino, Elisabete Carolino, Richard B Moss, Niaz Banaei, Cristina Verissimo, David A Stevens
Candida albicans is a common microbe, colonizer and potential pathogen found in respiratory cultures of cystic fibrosis (CF) patients. Because of possible development of resistance in patient isolates resulting from residence in the abnormal milieu of CF patient airways, or from exposure to antifungals, and considering the possibility of patient-to-patient spread of microbes and reports of elevated resistance to other fungal pathogens, it was important to assay the susceptibility of isolates of Candida and compare that profile to isolates from the community...
April 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28378240/candida-albicans-germ-tube-antibody-evaluation-of-a-new-automatic-assay-for-diagnosing-invasive-candidiasis-in-icu-patients
#4
Manuel Parra-Sánchez, Ismail Zakariya-Yousef Breval, Carmen Castro Méndez, Silvia García-Rey, Ana Loza Vazquez, Alejandro Úbeda Iglesias, Desiree Macías Guerrero, Ana Romero Mejías, Cristobal León Gil, Estrella Martín-Mazuelos
Testing for Candida albicans germ-tube antibody IFA IgG assay (CAGTA) is used to detect invasive candidiasis infection. However, most suitable assays lack automation and rapid single-sample testing. The CAGTA assay was adapted in an automatic monotest system (invasive candidiasis [CAGTA] VirClia(®) IgG monotest (VirClia(®)), a chemiluminescence assay with ready-to-use reagents that provides a rapid objective result. CAGTA assay was compared with the monotest automatic VirClia(®) assay in order to establish the diagnostic reliability, accuracy, and usefulness of this method...
April 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28378239/usefulness-of-1-3-beta-d-glucan-detection-in-non-hiv-immunocompromised-mechanical-ventilated-critically-ill-patients-with-ards-and-suspected-pneumocystis-jirovecii-pneumonia
#5
Tobias Lahmer, Clarissa Prazeres da Costa, Jürgen Held, Sebastian Rasch, Ursula Ehmer, Roland M Schmid, Wolfgang Huber
INTRODUCTION: Pneumocystis jirovecii pneumonia (PCP) is a major cause of disease in immunocompromised individuals. Diagnosis is typically obtained by microscopy and/or PCR. For ambiguous PCR results, we evaluated the new biomarker 1,3-Beta-D-Glucan (BDG). METHODS: BDG serum levels were assessed and correlated to PCR results in immunosuppressed patients with ARDS. RESULTS: 11 (22%) out of 50 patients had suspected PCP. APACHE II (26 vs. 24; p < 0...
April 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28365835/paecilomyces-variotii-fungemia-in-a-patient-with-lymphoma-needing-liver-transplant
#6
A P Bellanger, J P Cervoni, J F Faucher, D Weil-Verhoeven, M Ginet, E Deconinck, F Grenouillet
Paecilomyces sp. are emerging pathogens in immunocompromised patients. We report here a case of Paecilomyces variotii fungemia, cured with amphotericin and anidulafungin, illustrating difficulties of early diagnosis and therapeutic choice in such rare fungal infection.
April 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28349349/acute-disseminated-talaromyces-marneffei-in-an-immunocompetent-patient
#7
Pingli Wang, Youfei Chen, Hao Xu, Liren Ding, Zuqun Wu, Zhijiang Xu, Kai Wang
Talaromyces marneffei (also called Penicilliosis Marneffei or T. marneffei) is a rare fungal disease that is prevalent mainly in Southeast Asia and commonly seen in immunocompromised hosts. It was rarely observed in immunocompetent hosts. We report a case of acute disseminated T. marneffei in an immunocompetent patient in the non-prevalent region. This patient had never visited the endemic area. The patient experienced a persistent fever. Brain CT and magnetic resonance imaging (MRI) showed a mass in the right frontal with osteolytic damage...
March 27, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28337637/in-vivo-paracoccidioides-sp-biofilm-on-vascular-prosthesis
#8
Maria Emilia Cattana, Maria Fernanda Tracogna, Isabel Marques, Florencia Rojas, Mariana Fernández, María de Los Ángeles Sosa, Javier Mussin, Gustavo Giusiano
Paracoccidioidomycosis is an endemic mycosis caused by Paracoccidioides species limited to Latin America arising with the chronic form in 90% of cases. The capacity of microorganisms to form biofilms is considered of great importance medical since can contribute to the persistence and to the chronic state of the diseases. The ability of Paracoccidioides to form biofilm has been demonstrated in vitro. In our study, for the first time we have observed this capability in vivo on a vascular prosthesis using scanning electron microscope showing a dense network of Paracoccidioides yeasts covered by an extracellular matrix...
March 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28324245/comparison-of-dna-microarray-loop-mediated-isothermal-amplification-lamp-and-real-time-pcr-with-dna-sequencing-for-identification-of-fusarium-spp-obtained-from-patients-with-hematologic-malignancies
#9
Marcela de Souza, Tetsuhiro Matsuzawa, Kanae Sakai, Yasunori Muraosa, Luzia Lyra, Ariane Fidelis Busso-Lopes, Anna Sara Shafferman Levin, Angélica Zaninelli Schreiber, Yuzuru Mikami, Tohoru Gonoi, Katsuhiko Kamei, Maria Luiza Moretti, Plínio Trabasso
The performance of three molecular biology techniques, i.e., DNA microarray, loop-mediated isothermal amplification (LAMP), and real-time PCR were compared with DNA sequencing for properly identification of 20 isolates of Fusarium spp. obtained from blood stream as etiologic agent of invasive infections in patients with hematologic malignancies. DNA microarray, LAMP and real-time PCR identified 16 (80%) out of 20 samples as Fusarium solani species complex (FSSC) and four (20%) as Fusarium spp. The agreement among the techniques was 100%...
March 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28324244/animal-models-and-antifungal-agents-in-paracoccidioidomycosis-an-overview
#10
REVIEW
Luciano Z Goldani, Fernanda Wirth
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America. The morbidity and mortality associated with paracoccidioidomycosis necessitate our understanding of fungal pathogenesis and discovering of new agents to treat this infection. Animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. This is true for animal models of the primary fungal pathogens such as P. brasiliensis...
March 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28324243/fungal-keratitis-secondary-to-trametes-betulina-a-case-report-and-review-of-literature
#11
Joshua S Hardin, Deanna A Sutton, Nathan P Wiederhold, James Mele, Sunali Goyal
PURPOSE: We report the first case of human infection and keratitis secondary to Trametes betulina, a rare filamentous fungus. METHODS: Clinical examination including external and slit-lamp examination and corneal scrapings with microbiologic evaluation were performed on a patient with chronic allergic conjunctivitis, entropion and a long-standing corneal ulcer resistant to treatment. RESULTS: The culture from the corneal scraping revealed a basidiomycetous fungus which was submitted for identification...
March 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28281037/pathogenic-dermatophytes-survive-in-nail-lesions-during-oral-terbinafine-treatment-for-tinea-unguium
#12
Tomoyuki Iwanaga, Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki
Tinea unguium caused by dermatophyte species are usually treated with oral antimycotic, terbinafine (TBF). To understand the mechanisms of improvement and recalcitrance of tinea unguium by oral TBF treatment, a method of quantifying dermatophyte viability in the nail was developed, and the viability of dermatophytes was analyzed in toenail lesions of 14 patients with KOH-positive tinea unguium treated with oral TBF 125 mg/day for up to 16 weeks. Mycological tests, including KOH examination and fungal culture, and targeted quantitative real-time PCR for internal transcribed spacer (ITS) region, including rRNA, were demonstrated at the initial visit and after 8 and 16 weeks of treatment...
March 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28260132/imported-talaromycosis-in-oman-in-advanced-hiv-a-diagnostic-challenge-outside-the-endemic-areas
#13
Jalila Mohsin, Sulin Al Khalili, A H G Gerrits van den Ende, Faryal Khamis, Eskild Petersen, G Sybren de Hoog, Jacques F Meis, Abdullah M S Al-Hatmi
A 37-year-old male living in Oman was seen by his physician with complaints of cough, body aches with bilateral lower limb weakness and on and off fever. He was diagnosed with HIV infection and culture from blood and bone marrow grew Talaromyces marneffei. He had travelled to Malaysia on several occasions. Treatment with liposomal amphotericin B resulted in complete cure. This case is reported for its rarity and unusual presentation to alert clinicians and microbiologists to consider T. marneffei as an etiology in high risk individuals...
March 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28251567/fungal-succession-on-keratinous-hair-and-nail-baits-of-human-origin
#14
Sunita Mahariya, Meenakshi Sharma
Mycologically, succession is more precisely the sequential occupation of the same site by thalli (normally mycelia) either of different fungi or of different associations of fungi. For the study of fungal succession on hair bait, different soil samples were collected from different habitats of Jaipur. The fungal growth isolated from soil samples was observed macroscopically and microscopically for the appearance of fungi at regular interval of 15 days for more than 6 months. Regular microscopic examination of fungi of soil samples baited with hair showed a successional colonization of non-keratinophilic and keratinophilic fungi...
March 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28213800/invasive-aspergillus-laryngotracheobronchitis-in-an-adult-with-primary-cns-lymphoma
#15
Mark E Barry, William Walsh Thomas, Buer Song, Natasha Mirza
Invasive aspergillosis can be difficult to diagnose, and early recognition and initiation of therapy is imperative for improving patient outcomes. A case of invasive Aspergillus laryngotracheobronchitis is presented here with a review of the relevant literature. A 58-year-old male undergoing treatment for CNS lymphoma presented with neutropenic sepsis and acute respiratory distress requiring intubation. Following extubation, he reported persistent hoarseness for 1-month duration and he was found to have pseudomembranous plaques and ulcers of the larynx, trachea, and right mainstem bronchus consistent with Aspergillus laryngotracheobronchitis...
February 17, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28197828/coinfection-with-lichtheimia-corymbifera-and-aspergillus-flavus-in-an-immune-competent-patient-mimicking-as-pulmonary-renal-syndrome
#16
Ali Bin Sarwar Zubairi, Farah Idrees, Kauser Jabeen, Saima Kamal, Afia Zafar
Lichtheimia corymbifera and Aspergillus flavus pulmonary coinfection has been rarely reported in immune-competent patients. We report case of a young male who presented with clinical features of pulmonary-renal syndrome and was later diagnosed to have bilateral polymicrobial fungal lung infection.
February 14, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28190203/subcutaneous-mycotic-cyst-caused-by-roussoella-percutanea-in-a-uk-renal-transplant-patient
#17
Julia A Vasant, Francesca Maggiani, Andrew M Borman
Fungi from more than 100 genera have been implicated in subcutaneous fungal infections, usually following traumatic inoculation of the etiologic agent. With the advent of molecular approaches to fungal identification and taxonomy, novel agents of subcutaneous mycoses are increasingly reported. In this manner, Roussoella percutanea, a novel species in Pleosporales, was described in 2014 from a subcutaneous mass in an immunocompetent male adult. Two additional cases involving renal transplant recipients were recently reported from patients resident in France and Germany, with several further cases discovered after analyses of historical culture collection isolates...
February 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28154954/deep-dermatophytosis-caused-by-zoophilic-strain-of%C3%A2-trichophyton-interdigitale%C3%A2-with-successful-treatment-of-itraconazole
#18
Hsuan-An Su, Pei-Lun Sun, Wen-Wei Sung, Su-Ya Cheng, Hui-Chin Chang, Jen-Hung Yang, Yu-Ping Hsiao
We report a 66-year-old female patient with deep dermatophytosis caused by zoophilic strain of Trichophyton interdigitale, a rare granulomatous presentation of Trichophyton species infection in patients with underlying systemic diseases, and she was successfully cured by itraconazole. Since the identification of Trichophyton mentagrophytes complex had been misused for years, a brief discussion of molecular diagnosis and taxonomy of T. mentagrophytes complex is given. The pathogenesis and comparison with cases reported in the literature are also discussed...
February 2, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28144822/in-vitro-activity-of-berberine-alone-and-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-trichosporon-asahii
#19
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients, with high mortality rates up to 80% despite treated with antifungal drugs. The biofilms-forming ability of T. asahii on indwelling medical devices may account for the resistance to antifungal drugs. Berberine (BBR) has been demonstrated to have antifungal activity and synergistic effects in combination with antifungal drugs against pathogenic fungi. In the present study, the in vitro activities of BBR alone or combined with fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against planktonic forms and biofilms of 21 clinical T...
January 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28144821/nebulized-liposomal-amphotericin-b-for-treatment-of-pulmonary-infection-caused-by-hormographiella-aspergillata-case-report-and-literature-review
#20
Cendrine Godet, Estelle Cateau, Blandine Rammaert, Marine Grosset, Gwenaël Le Moal, Guillaume Béraud, Jean Philippe Martellosio, Xavier Iriart, Jacques Cadranel, France Roblot
Invasive fungal infection is a serious complication following allogeneic hematopoietic stem cell transplantation. Pulmonary infection due to Hormographiella aspergillata is an uncommon condition associated with a high mortality rate. The susceptibility of H. aspergillata to available antifungal agents is not well established. We report for the first time a case of H. aspergillata lung infection that responded poorly to conventional treatment with liposomal amphotericin B (LAmB; 3 mg kg(-1) of body weight per day) with renal damage at higher posology (5 mg kg(-1) of body weight per day), but improved rapidly after addition of nebulized LAmB to intravenous LAmB (3 mg kg(-1) of body weight per day)...
January 31, 2017: Mycopathologia
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