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Grasielle Pereira Jannuzzi, José Roberto Fogaça de Almeida, Suelen Silvana Dos Santos, Sandro Rogério de Almeida, Karen Spadari Ferreira
The Notch signaling pathway participates in several cellular functional aspects. This signaling has an important role in targeting both DC maturation and DC-mediated T cell responses. Thus, it is essential to investigate the influence of this signaling pathway in the role played by DCs in the pathogenesis of experimental paracoccidioidomycosis. This disease is a granulomatous and systemic mycosis that mainly affects lung tissue and can spread to any other organ and system. In this study, we demonstrated that bone marrow-derived DCs infected with yeasts from Paracoccidioides brasiliensis strain 18 performed efficiently their maturation after the activation of Notch signaling, with an increase in CD80, CD86, CCR7, and CD40 expression and the release of cytokines such as IL-6 and TNF-α...
June 18, 2018: Mycopathologia
Caroline S Silveira, Deborah Cesar, M Kelly Keating, Marlene DeLeon-Carnes, Aníbal G Armién, Martín Luhers, Franklin Riet-Correa, Federico Giannitti
Protothecosis is a rare disease caused by environmental algae of the genus Prototheca. These are saprophytic, non-photosynthetic, aerobic, colorless algae that belong to the Chlorellaceae family. Seven different species have been described. Prototheca zopfii genotype 2 and P. wickerhamii are most commonly involved in pathogenic infections in humans and animals. The objective of this work is to describe, for the first time, a case of protothecosis caused by P. zopfii genotype 1 in a dog. The dog, a 4-year-old mix bred male, was presented to a veterinary clinic in Montevideo, Uruguay, with multiple skin nodules, one of which was excised by surgical biopsy...
June 6, 2018: Mycopathologia
Hyeon-Jeong Lee, Sung-Yeon Cho, Dong-Gun Lee, Chulmin Park, Hye-Sun Chun, Yeon-Joon Park
Azole resistance in Aspergillus fumigatus is an emerging problem, especially in immunocompromised patients. It has been reported worldwide, including in Asia, but has not yet been reported in Korea. Here, we report a case of invasive pulmonary aspergillosis (IPA) caused by azole-resistant A. fumigatus that developed in a hematopoietic stem cell transplantation recipient during posaconazole prophylaxis for immunosuppressive therapy of graft-versus-host diseases. We identified TR34/L98H/S297T/F495L mutation in the CYP51A gene of A...
June 1, 2018: Mycopathologia
Clenivaldo Alves Caixeta, Marina Lara de Carli, Noé Vital Ribeiro Júnior, Felipe Fornias Sperandio, Suely Nonogaki, Denismar Alves Nogueira, Alessandro Antônio Costa Pereira, João Adolfo Costa Hanemann
BACKGROUND: Paracoccidioidomycosis is a neglected tropical fungal infection with great predilection for adult men, indicating the participation of female hormone estrogen in preventing paracoccidioidomycosis development in women. Estrogen has an immunologic effect leading to polarization toward the Th2 immune response, which favors the disease evolution. OBJECTIVES: To evaluate estrogen and progesterone receptors in oral paracoccidioidomycosis lesions and to verify any association with tissue fungi counting in women and men...
May 23, 2018: Mycopathologia
Pakpoom Phoompoung, Methee Chayakulkeeree, Popchai Ngamskulrungroj, Ananya Pongpaibul
Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world's first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient's liver showed infiltration of fungal organisms in portal vein and hepatic granulomas...
May 22, 2018: Mycopathologia
Shotaro Nakagun, Masako Okazaki, Takahito Toyotome, Nobuki Sugiyama, Kenichi Watanabe, Noriyuki Horiuchi, Yoshiyasu Kobayashi
A 4-year-old captive ringed seal (Pusa hispida) was treated with subcutaneous antibacterial injections for pus exuding wounds in the skin and associated blubber following a bite attack. Three months after the incident, the animal presented nystagmus and died the following day. At necropsy, there was a 25 × 18 × 25 mm well-delineated, opaque nodular mass in the lung, besides the skin ulcers and localized areas of discoloration in the blubber correlating with the bite wound and injection sites. Histopathology of the pulmonary mass demonstrated severe eosinophilic inflammatory infiltration among numerous intralesional fungal hyphae...
May 22, 2018: Mycopathologia
Qing Cai, Lian-Juan Yang, Jia Chen, Hong Yang, Zhi-Qin Gao, Xiu-Li Wang
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues...
May 16, 2018: Mycopathologia
Laura Reisfeld, Carlos Sacristán, Paloma Canedo, Bruna Schwarz, Ana Carolina Ewbank, Fernando Esperón, José Luiz Catão-Dias
Superficial mycoses are commonly reported in captive pinnipeds, usually maintained in wet and warm environments, favorable to fungal growth. Most superficial mycoses in pinnipeds have been described as difficult to treat; however, the majority of the reports come from past decades. Cutaneous lesions associated with opportunistic Fusarium sp. infections have been previously recognized in this taxon. We described the clinical signs, associated lesions and diagnosis (thermography, imprint cytology, histopathology, culture, electron microscopy, PCR) of a fusariosis case by Fusarium sp...
May 14, 2018: Mycopathologia
M J Najafzadeh, V A Vicente, Peiying Feng, A Naseri, Jiufeng Sun, A Rezaei-Matehkolaei, G S de Hoog
The Editorial Office of Mycopathologia reports that several paragraphs of Najafzadeh et al. were transcribed with only minor edits from previously published material by Najafzadeh M.J.
May 14, 2018: Mycopathologia
Wenhao Cao, Cui Jian, Huojun Zhang, Shuyun Xu
Whether the clinical features of cryptococcal meningitis (CM) patients vary with the coexistence of pulmonary nodules is not clear. This study aimed to compare the clinical features of CM in patients with and without pulmonary nodules detected by chest computed tomography (CT). The medical records of CM patients hospitalized in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 1, 2010, to December 31, 2016, were retrospectively reviewed. Baseline demographics, laboratory and radiographic findings, clinical managements, and outcomes were analyzed...
May 8, 2018: Mycopathologia
Larissa de Oliveira Souza Beltrão, Mayara Pangracio, Cacilda da Silva Souza
We discuss the sarcoid-like clinical presentation, a rare type of infiltrative paracoccidioidomycosis (PCM) that is almost exclusively cutaneous, involves the face and histologically has a tuberculoid granulomatous pattern with few fungi. It is often misdiagnosed. In endemic regions of Brazil, PCM is more common among men from rural areas, while women of a reproductive age appear to be protected. We report the sarcoid-like PCM in a female urban dweller and highlight the main findings of a literature review.
May 8, 2018: Mycopathologia
Heidi G Rodriguez-Ramirez, Adolfo Soto-Dominguez, Gloria M González, Oralia Barboza-Quintana, Mario C Salinas-Carmona, Luis A Ceceñas-Falcon, Roberto Montes-de-Oca-Luna, Alma Y Arce-Mendoza, Adrian G Rosas-Taraco
Coccidioidomycosis is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii. These fungi are endemic in the southern USA and northern Mexico. Immunocompromised patients are susceptible to develop severe forms of this fungal infection. Cytokines play an important role in controlling the fungal infection, but little is known about the predominant immunological environment in human lung tissue from fatal cases. Our aim was to analyze the pro-inflammatory and anti-inflammatory cytokines and monocyte/macrophages markers (CD14 and CD206) in the granulomas of six fatal cases of coccidioidomycosis...
May 7, 2018: Mycopathologia
Süleyha Hilmioğlu-Polat, Somayeh Sharifynia, Yasemin Öz, Müge Aslan, Nuray Gündoğdu, Ayşe Serin, Haleh Rafati, Faezeh Mohammadi, Dilek Yeşim-Metin, Aylin Döğen, Macit Ilkit, Seyedmojtaba Seyedmousavi
Candida parapsilosis sensu stricto is an emerging cause of hospital-acquired Candida infections, predominantly in southern Europe, South America, and Asia. We investigated the genetic diversity and antifungal susceptibility profile of 170 independent C. parapsilosis sensu stricto strains obtained from patients with candidemia who were treated at the Ege University Hospital in Izmir, Turkey, between 2006 and 2014. The identity of each strain was confirmed via PCR amplification and digestion of the secondary alcohol dehydrogenase-encoding gene...
May 3, 2018: Mycopathologia
Yuko Matsuda, Otomi Cho, Takashi Sugita, Daiki Ogishima, Satoru Takeda
PURPOSE: Vulvovaginal candidiasis (VVC) is a common superficial infection of the vaginal mucous membranes caused by the fungus Candida albicans. The aim of this study was to assess the mechanisms underlying the inhibitory effects of the culture supernatants of Lactobacillus gasseri and L. crispatus, the predominant microbiota in Asian healthy women, on C. albicans biofilm formation. The inhibition of C. albicans adhesion to HeLa cells by Lactobacillus culture supernatant was also investigated...
March 30, 2018: Mycopathologia
Priya Madhavan, Farida Jamal, Chong Pei Pei, Fauziah Othman, Arunkumar Karunanidhi, Kee Peng Ng
Infections by non-albicans Candida species are a life-threatening condition, and formation of biofilms can lead to treatment failure in a clinical setting. This study was aimed to demonstrate the in vitro antibiofilm activity of fluconazole (FLU) and voriconazole (VOR) against C. glabrata, C. parapsilosis and C. rugosa with diverse antifungal susceptibilities to FLU and VOR. The antibiofilm activities of FLU and VOR in the form of suspension as well as pre-coatings were assessed by XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] reduction assay...
June 2018: Mycopathologia
Barbara Hartl, Iris Zeller, Angelika Manhart, Brigitte Selitsch, Cornelia Lass-Flörl, Birgit Willinger
Because of their high mortality rates and non-specific symptoms, invasive Candida infections pose a huge diagnostic and therapeutic challenge. In this study, we evaluated the three mannan antigen assays Platelia, Platelia Plus and Serion, and the (1-3)-β-D-glucan assay Fungitell in a group of high-risk (hematological and surgical) patients. Test results of 305 patients hospitalized at the Vienna General Hospital and the University Hospital of Innsbruck were retrospectively analyzed. We assessed the test accuracy by means of descriptive statistics...
June 2018: Mycopathologia
Sujeesh Sebastian, Rajesh Malhotra, Ashish Pande, Deepak Gautam, Immaculata Xess, Benu Dhawan
Fungal prosthetic joint infection is a rare complication in total joint arthroplasty. There are no established guidelines for management of these infections. We present a case of a 53-year-old male with a hip joint prosthesis co-infected with Candida tropicalis and Staphylococcus haemolyticus. A two-stage exchange arthroplasty was performed. The patient underwent implant removal, debridement, irrigation with saline solution and application of cement spacer impregnated with vancomycin followed by aggressive antimicrobial treatment in first stage...
June 2018: Mycopathologia
Damien Dupont, Antoine Huguenin, Elodie Tisserand, Véronique Reiter, Emmanuel Morelon, Lionel Badet, Isabelle Villena, Martine Wallon, Dominique Toubas
We report here a case of possible donor-derived Candida stellimalicola infection after pancreas transplantation. Candida stellimalicola, an environmental non-filamentous yeast, was isolated from both the peritoneal fluid of the graft donor and the preservation fluid of the transplanted pancreas. Interestingly, this strain exhibited high minimum inhibitory concentrations to azoles. These results justified the use of echinocandins as therapy instead of fluconazole. This switch permitted a favorable outcome. To our knowledge, this is the first report of C...
June 2018: Mycopathologia
Sunita Mahariya, Meenakshi Sharma
Mycologically, succession is more precisely the sequential occupation of the same site by thalli (normally mycelia) either of different fungi or of different associations of fungi. For the study of fungal succession on hair bait, different soil samples were collected from different habitats of Jaipur. The fungal growth isolated from soil samples was observed macroscopically and microscopically for the appearance of fungi at regular interval of 15 days for more than 6 months. Regular microscopic examination of fungi of soil samples baited with hair showed a successional colonization of non-keratinophilic and keratinophilic fungi...
June 2018: Mycopathologia
Masaaki Yoshida, Naoki Kiyota, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Toyokawa, Shigehiro Hagiwara, Koichi Makimura, Naomi Sato, Shinji Taniuchi, Toru Nakazawa
Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us...
April 2018: Mycopathologia
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