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Mycopathologia

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https://www.readbyqxmd.com/read/29603066/culture-supernatants-of-lactobacillus-gasseri-and-l-crispatus-inhibit-candida-albicans-biofilm-formation-and-adhesion-to-hela-cells
#1
Yuko Matsuda, Otomi Cho, Takashi Sugita, Daiki Ogishima, Satoru Takeda
PURPOSE: Vulvovaginal candidiasis (VVC) is a common superficial infection of the vaginal mucous membranes caused by the fungus Candida albicans. The aim of this study was to assess the mechanisms underlying the inhibitory effects of the culture supernatants of Lactobacillus gasseri and L. crispatus, the predominant microbiota in Asian healthy women, on C. albicans biofilm formation. The inhibition of C. albicans adhesion to HeLa cells by Lactobacillus culture supernatant was also investigated...
March 30, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29572768/candidemia-in-adults-at-a-tertiary-hospital-in-china-clinical-characteristics-species-distribution-resistance-and-outcomes
#2
Shaoming Lin, Ruilan Chen, Song Zhu, Huijun Wang, Lianfang Wang, Jian Zou, Jingdong Yan, Xiangdong Zhang, Dimitrios Farmakiotis, Xiaojiang Tan, Eleftherios Mylonakis
BACKGROUND: Candidemia is one of the most common nosocomial bloodstream infections. Early diagnosis and antifungal treatment improve clinical outcomes in some studies but not all, with diverse data reported from different institutions. Similarly, antifungal resistance is more common in the USA than in Europe, but there is little data regarding the microbiology and clinical course of candidemia in adult patients in Asia. AIMS: (1) To capture species distribution and drug resistance rates among Candida bloodstream isolates, (2) to describe clinical features of candidemia, and (3) to identify factors associated with all-cause mortality, with emphasis on early initiation of antifungal treatment, at a large tertiary University Hospital in China...
March 23, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29564632/infections-caused-by-fusarium-species-in-pediatric-cancer-patients-and-review-of-published-literature
#3
Mariana Volpe Arnoni, Claudete Rodrigues Paula, Marcos Ereno Auler, Cirilo Cesar Naozuka Simões, Shirley Nakano, Maria Walderez Szeszs, Márcia de Souza Carvalho Melhem, Virgínia Bodelão Richini Pereira, Hans Garcia Garces, Eduardo Bagagli, Eriques Gonçalves Silva, Melissa Ferreira de Macêdo, Luciana da Silva Ruiz
Fusarium species have emerged as responsible for a broad spectrum of infections, including superficial, locally invasive and disseminated ones, especially in the hospital environment. Since there are few reports of invasive and disseminated fusariosis in children, the aim of this study was to report four cases of nosocomial infection caused by this microorganism in children with cancer hospitalized in a public children's hospital located in Brazil. Two of these patients were female and two were male. All patients presented febrile neutropenia, while three patients had acute lymphocytic leukemia and one patient had Wilms' tumor as underlying disease...
March 21, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29557534/mycetoma-in-the-togolese-an-update-from-a-single-center-experience
#4
Tchin Darré, Bayaki Saka, Abas Mouhari-Toure, Mazamaesso Tchaou, Améyo Monique Dorkenoo, Kwamé Doh, Atchi Walla, Koffi Amégbor, Vincent Palokinam Pitché, Gado Napo-Koura
BACKGROUND: Mycetoma is a chronic inflammatory process caused either by fungi (eumycetoma) or bacteria (actinomycetoma). In this retrospective study, we report epidemiologic and histopathological data of mycetoma observed in the Lome Hospital, Togo in a 25-year period (1992-2016). METHODOLOGY: This is a retrospective study, over a period of 25 years, to analyze epidemiological and etiological findings of mycetomas seen in the single laboratory of pathological anatomy of the Lomé, Togo...
March 20, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29524085/a-literature-review-of-blood-disseminated-p-marneffei-infection-and-a-case-study-of-this-infection-in-an-hiv-negative-child-with-comorbid-eosinophilia
#5
Xiu-Jing Han, Dan-Hong Su, Jian-Yun Yi, Ya-Wei Zou, Yu-Ling Shi
BACKGROUND: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia. CASE PRESENTATION: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea...
March 9, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29504057/rapid-identification-of-seven-waterborne-exophiala-species-by-rca-dna-padlock-probes
#6
M J Najafzadeh, V A Vicente, Peiying Feng, A Naseri, Jiufeng Sun, A Rezaei-Matehkolaei, G S de Hoog
The black yeast genus Exophiala includes numerous potential opportunistic species that potentially cause systematic and disseminated infections in immunocompetent individuals. Species causing systemic disease have ability to grow at 37-40 °C, while others consistently lack thermotolerance and are involved in diseases of cold-blooded, waterborne vertebrates and occasionally invertebrates. We explain a fast and sensitive assay for recognition and identification of waterborne Exophiala species without sequencing...
March 5, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29500637/rna-seq-profile-reveals-th-1-and-th-17-type-of-immune-responses-in-mice-infected-systemically-with-aspergillus-fumigatus
#7
Jata Shankar, Gustavo C Cerqueira, Jennifer R Wortman, Karl V Clemons, David A Stevens
With the increasing numbers of immunocompromised hosts, Aspergillus fumigatus emerges as a lethal opportunistic fungal pathogen. Understanding innate and acquired immunity responses of the host is important for a better therapeutic strategy to deal with aspergillosis patients. To determine the transcriptome in the kidneys in aspergillosis, we employed RNA-Seq to obtain single 76-base reads of whole-genome transcripts of murine kidneys on a temporal basis (days 0; uninfected, 1, 2, 3 and 8) during invasive aspergillosis...
March 2, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29500636/laboratory-diagnosis-and-characterization-of-fungal-disease-in-patients-with-cystic-fibrosis-cf-a-survey-of-current-uk-practice-in-a-cohort-of-clinical-microbiology-laboratories
#8
Maeve Boyle, John E Moore, Joanna L Whitehouse, Diana Bilton, Damian G Downey
There is much uncertainty as to how fungal disease is diagnosed and characterized in patients with cystic fibrosis (CF). A 19-question anonymous electronic questionnaire was developed and distributed to ascertain current practice in clinical microbiology laboratories providing a fungal laboratory service to CF centres in the UK. Analyses of responses identified the following: (1) current UK laboratory practice, in general, follows the current guidelines, but the scope and diversity of what is currently being delivered by laboratories far exceeds what is detailed in the guidelines; (2) there is a lack of standardization of fungal tests amongst laboratories, outside of the current guidelines; (3) both the UK CF Trust Laboratory Standards for Processing Microbiological Samples from People with Cystic Fibrosis and the US Cumulative Techniques and Procedures in Clinical Microbiology (Cumitech) Guidelines 43 Cystic Fibrosis Microbiology need to be updated to reflect both new methodological innovations, as well as better knowledge of fungal disease pathophysiology in CF; (4) there is a need for clinical medicine to decide upon a stratification strategy for the provision of new fungal assays that will add value to the physician in the optimal management of CF patients; (5) there is also a need to rationale what assays should be performed at local laboratory level and those which are best served at National Mycology Reference Laboratory level; and (6) further research is required in developing laboratory assays, which will help ascertain the clinical importance of 'old' fungal pathogens, as well as 'emerging' fungal pathogens...
March 2, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29497926/antifungal-activity-of-chitosan-coated-poly-lactic-co-glycolic-acid-nanoparticles-containing-amphotericin-b
#9
Daniel Brustolin Ludwig, Luciana Erzinger Alves de Camargo, Najeh Maissar Khalil, Marcos Ereno Auler, Rubiana Mara Mainardes
Amphotericin B (AmB) is one of the most used drugs for the treatment of systemic fungal infections; however, the treatment causes several toxic manifestations, including nephrotoxicity and hemolytic anemia. Chitosan-coated poly(lactide-co-glycolide) (PLGA) nanoparticles containing AmB were developed with the aim to decrease AmB toxicity and propose the oral route for AmB delivery. In this work, the antifungal efficacy of chitosan-coated PLGA nanoparticles containing AmB was evaluated in 20 strains of fungus isolates from patients with vulvovaginal candidiasis (01 Candida glabrata and 03 Candida albicans), bloodstream infections (04 C...
March 1, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29476307/paracoccidioides-brasiliensis-infection-mimicking-recurrent-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#10
Ayaz Ghani, Molly Weinberg, Nusrat Pathan, Ramapriya Vidhun, Steven Sieber
Paracoccidioides infection is a rare entity in the USA. This dimorphic fungus is found in Central and South America and is thought to be acquired by inhalation through the soil. We report a case of Paracoccidioides brasiliensis infection presenting as a clavicular bone lesion, peripancreatic mass, and various skin lesions. A 35-year-old man with a history significant for Hodgkin lymphoma presented with a left clavicular mass that was suspected clinically and radiologically as recurrent Hodgkin lymphoma. He was not experiencing any associated symptoms and was undergoing chemotherapy treatment for his known Hodgkin disease...
February 23, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29453699/unusual-intestinal-involvement-by-paracoccidioidomycosis-diagnosed-after-oral-manifestation
#11
Rodrigo Neves-Silva, Patrícia Maria Fernandes, Alan Roger Santos-Silva, Pablo Agustin Vargas, Ricardo de Souza Cavalcante, Marcio Ajudarte Lopes
Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29453698/corneal-collagen-cross-linking-for-the-management-of-mycotic-keratitis
#12
Elif Erdem, Ibrahim Inan Harbiyeli, Hazal Boral, Macit Ilkit, Meltem Yagmur, Reha Ersoz
PURPOSE: To evaluate the efficiency of corneal collagen cross-linking (CXL) in addition to topical voriconazole in cases with mycotic keratitis. DESIGN: Retrospective case series in a tertiary university hospital. PARTICIPANTS: CXL was performed on 13 patients with mycotic keratitis who presented poor or no response to topical voriconazole treatment. METHODS: The clinical features, symptoms, treatment results and complications were recorded retrospectively...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29445920/phylogenetic-diversity-and-in-vitro-susceptibility-profiles-of-human-pathogenic-members-of-the-fusarium-fujikuroi-species-complex-isolated-from-south-india
#13
Ananya Tupaki-Sreepurna, Vijayakishore Thanneru, Sangeetha Natarajan, Savitri Sharma, Anjana Gopi, Murugan Sundaram, Anupma Jyoti Kindo
Availability of molecular methods, gene sequencing, and phylogenetic species recognition have led to rare fungi being recognized as opportunistic pathogens. Fungal keratitis and onychomycosis are fairly common mycoses in the tropics, especially among outdoor workers and enthusiasts. The frequently isolated etiological agents belong to genera Candida, Aspergillus, and Fusarium. Within the genus Fusarium, known to be recalcitrant to prolonged antifungal treatment and associated with poor outcome, members of the Fusarium solani species complex are reported to be most common, followed by members of the Fusarium oxysporum SC and the Fusarium fujikuroi SC (FFSC)...
February 14, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29383575/antifungal-susceptibility-morphological-and-molecular-characterization-of-lasiodiplodia-theobromae-isolated-from-a-patient-with-keratitis
#14
Priscila Dallé da Rosa, Claudete Locatelli, Karla Scheid, Diane Marinho, Lúcia Kliemann, Alexandre Fuentefria, Luciano Zubaran Goldani
Lasiodiplodia theobromae is a rare ocular pathogen. We report a patient with fungal keratitis caused by L. theobromae. The patient was a 75-year-old male, a farmer with diabetes type II, and no previous history of ocular trauma. Histopathology analysis revealed the presence fungi invading Descemet's membrane of the cornea. The fungus was characterized by septate, highly bulged fungal filaments involving full corneal thickness in the corresponding histopathology specimens. A dematiaceous mold was isolated and initally identified as L...
January 30, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29383574/a-fatal-case-of-candida-auris-and-candida-tropicalis-candidemia-in-neutropenic-patient
#15
Ratna Mohd Tap, Teck Choon Lim, Nur Amalina Kamarudin, Stephanie Jane Ginsapu, Mohd Fuat Abd Razak, Norazah Ahmad, Fairuz Amran
We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested...
January 30, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29380188/comparative-study-of-the-effects-of-fluconazole-and-voriconazole-on-candida-glabrata-candida-parapsilosis-and-candida-rugosa-biofilms
#16
Priya Madhavan, Farida Jamal, Chong Pei Pei, Fauziah Othman, Arunkumar Karunanidhi, Kee Peng Ng
Infections by non-albicans Candida species are a life-threatening condition, and formation of biofilms can lead to treatment failure in a clinical setting. This study was aimed to demonstrate the in vitro antibiofilm activity of fluconazole (FLU) and voriconazole (VOR) against C. glabrata, C. parapsilosis and C. rugosa with diverse antifungal susceptibilities to FLU and VOR. The antibiofilm activities of FLU and VOR in the form of suspension as well as pre-coatings were assessed by XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] reduction assay...
January 29, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29380187/correction-to-resistance-mechanism-in-a-terbinafine-resistant-strain-of-microsporum-canis
#17
Rui Kano, Yun-Hsia Hsiao, Hock Siew Han, Charles Chen, Atsuhiko Hasegawa, Hiroshi Kamata
In the initial online publication, the name of author Hock Siew Han was given incorrectly as Han Hock Siew. The original article has been corrected.
January 29, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29380186/the-effect-of-some-natural-essential-oils-against-bovine-mastitis-caused-by-prototheca-zopfii-isolates-in-vitro
#18
Barbara Grzesiak, Barbara Kołodziej, Anna Głowacka, Henryk Krukowski
The aim of the study was to evaluate the effect of essential oils obtained from Thymus vulgaris L., Origanum vulgare L., Origanum majerana L., Mentha × piperita L. and Allium ursinum L. against Prototheca zopfii strains that cause inflammation of the udder (mastitis) in cows. The study was conducted on ten strains derived from milk samples. The microdilution method was used to determine the sensitivity of P. zopfii strains to the studied essential oils, and the disk diffusion method was used to determine the sensitivity to antifungal chemotherapeutics...
January 27, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29374798/exophiala-dermatitidis-endophthalmitis-case-report-and-literature-review
#19
Mónika Homa, Palanisamy Manikandan, Veerappan Saravanan, Rajaraman Revathi, Raghavan Anita, Venkatapathy Narendran, Kanesan Panneerselvam, Coimbatore Subramanian Shobana, Mohammed Al Aidarous, László Galgóczy, Csaba Vágvölgyi, Tamás Papp, László Kredics
We report a case of a 59-year-old male patient with a postoperative fungal infection of the left eye. A dark-pigmented yeast, Exophiala dermatitidis (previously known as Wangiella dermatitidis), was identified from the culture of the biopsy taken from the posterior capsule. The infection was successfully eradicated by a combination of surgical and medical (i.e., voriconazole and fluconazole) treatment. This is the first report of successfully treated E. dermatitidis endophthalmitis, which demonstrates that a prompt and aggressive antifungal therapy combined with surgical intervention is necessary to prevent vision loss in cases of endophthalmitis due to Exophiala species...
January 27, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29249044/endogenous-fusarium-endophthalmitis-during-treatment-for-acute-myeloid-leukemia-successfully-treated-with-25-gauge-vitrectomy-and-antifungal-medications
#20
Masaaki Yoshida, Naoki Kiyota, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Toyokawa, Shigehiro Hagiwara, Koichi Makimura, Naomi Sato, Shinji Taniuchi, Toru Nakazawa
Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us...
April 2018: Mycopathologia
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