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Medical Hypotheses

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https://www.readbyqxmd.com/read/27836221/corrigendum-to-paradigm-shift-redefining-molecular-metabolic-and-structural-events-in-alzheimer-s-disease-involves-a-proposed-contribution-by-transition-metals-defined-lengthy-preclinical-stage-provides-new-hope-to-circumvent-advancement-of-disease-and-age
#1
https://www.readbyqxmd.com/read/27665504/guest-editorial-how-stress-changes-the-brain-and-causes-a-cluster-of-uniquely-human-diseases
#2
Arnold E Eggers
No abstract text is available yet for this article.
September 17, 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27663632/the-effects-of-stress-on-the-dorsal-raphe-nucleus-of-the-reticular-formation-and-its-role-in-the-aetiology-of-disparate-medical-and-neuropsychiatric-disorders
#3
https://www.readbyqxmd.com/read/27876140/retinal-pigment-epithelium-cell-derived-exosomes-possible-relevance-to-cnv-in-wet-age-related-macular-degeneration
#4
Yao Tong, Ya-Li Zhou, Yi-Xiao Wang, Pei-Quan Zhao, Zhao-Yang Wang
Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes taken from the aqueous humor (AH) of patients with wet-age related macular degeneration (AMD) may function as a new diagnostic biomarker of AMD, suggesting that exosomes may play an important role in the occurrence and development of choroidal neovascularization (CNV)...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876139/conversations-between-insulin-and-bone-potential-mechanism-of-high-bone-density-in-patients-with-berardinelli-seip-congenital-lipodystrophy
#5
Josivan Gomes Lima, Natalia Nobrega Lima, Lucia Helena C Nobrega, Selma Maria B Jeronimo
Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a difficulty storing lipid in adipocytes, low body fat, hypertriglyceridemia, and fat liver. The serum leptin is usually very low, and serum insulin, as well as HOMAIR (homeostasis model assessment), is very high and correlated positively with bone mineral density (BMD). Despite deficiency/insufficiency of vitamin D, low body mass index, low daily calcium intake, physical inactivity, and menarche at a later age, BSCL patients usually have normal or even high BMD...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876138/adenomatoid-odontogenic-tumor-what-is-the-true-nature
#6
Arush Thakur, Jagdish Vishnu Tupkari, Tabita Joy, Amrut V Hanchate
The Adenomatoid odontogenic tumor (AOT) is one of the most controversial benign odontogenic tumor, which has been known to the pathologists for the past 100years. Since then the history, histogenesis and histopathologic designation of AOT remains a matter of debate. Some authors consider it as a true benign neoplasm while others consider it as a hamartoma and still others as an odontogenic cyst. Here we propose that the AOT should not be considered as a cyst because its true cystic nature remains questionable...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876137/cathepsin-k-the-association-between-cathepsin-k-expression-and-sphenoid-sinus-invasion-of-pituitary-adenomas
#7
Hongyan Liu, Guoqi Wang, Weijun Gu, Yiming Mu
Pituitary adenomas with sphenoid sinus or clivus invasion are not uncommon, but the pathogenesis responsible for this phenomenon remains unclear. Cathepsin K, expressed predominantly in osteoclasts, can degrade type I collagen and plays an essential role in bone resorption. Recent studies reported the expression of Cathepsin K in various malignant tumors, such as bone, breast, lung and prostate cancers, and its expression is further increased in bone metastasis or invasive subpopulations. In addition, cathepsin K inhibitors (CatKi) were demonstrated to effectively prevent or reduce osteolytic lesions in breast cancers with bone metastasis...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876136/worse-or-better-cirrhosis-with-hepatocellular-carcinoma
#8
Ran Xue, Qinghua Meng, Juan Li, Jiliang Feng, Hanping Shi
Hepatocellular carcinoma (HCC) accounts for about 90% of all malignant tumors of liver, ranking fifth in the worldwide incidence of malignant tumors and the third in fatality. More and more evidences suggest that cancer is a metabolic-related disease. From the analysis of recent clinical research data, we found that as the severity of the cirrhosis aggravated, patients with HCC and end-stage liver cirrhosis had a flat energy metabolism which was better than it in patients with simple end-stage liver cirrhosis...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876135/from-molecules-to-behavior-an-integrative-theory-of-autism-spectrum-disorder
#9
Alexandru-Ştefan Niculae, Denis Pavăl
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders for which various theories have been proposed. Each theory brings valuable insights and has experimental evidence backing it, yet none provides an overarching explanation for each of the pathological aspects involved in ASD. Here we present an integrative theory of ASD, centered on a sequence of events spanning from the molecular to the behavioral level. We propose that an abnormality in the interplay between retinoic acid and sex hormones predisposes an individual to specific molecular malfunctions...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876134/geniuses-of-medical-science-friendly-open-and-responsible-not-mad
#10
Maitane Oscoz-Irurozqui, Felipe Ortuño
Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876133/skin-phenotypes-can-offer-some-insight-about-the-association-between-telomere-length-and-cancer-susceptibility
#11
S Ribero, M Mangino, V Bataille
The role of telomere biology in cancer has been studied for a wide variety of different cancers but the association with telomere length has been controversial. This is because some cancers have been found to be associated with longer telomeres in circulating white cells whilst other cancer types are more common in individuals with shorter telomeres. Hence, there has been some skepticism as to whether telomere length may be helpful in estimating cancer risk. For melanoma, however, results have been fairly consistent showing that longer telomeres are associated with an increased risk...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876132/possible-role-of-intronic-polymorphisms-in-the-phactr1-gene-on-the-development-of-cardiovascular-disease
#12
José Manuel Rodríguez-Pérez, Ruben Blachman-Braun, Alan Pomerantz, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández
Cardiovascular disease (CVD) is a complex multifactorial and polygenetic disease in which the interaction of numerous genes, genetic variants, and environmental factors plays a major role in its development. In an attempt to demonstrate the association between certain genetic variants and CVD, researchers have run large genomic wild association studies (GWAS) in recent decades. These studies have correlated several genomic variants with the presence of CVD. Recently, certain polymorphisms in the phosphatase and actin regulator 1 (PHACTR1) gene have been shown to be associated with CVD (i...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876131/chemosensitization-role-of-fulvestrant-in-combination-with-chemotherapy-in-postmenopausal-hormone-receptor-positive-and-human-epidermal-growth-factor-negative-metastatic-breast-cancer
#13
Qing-Qing Luo, Vishnu Prasad Adhikari, Chun-Xia Zhao, He Wu, Wei Dai, Xin Li, Yu-Tuan Wu, Kai-Nan Wu, Ling-Quan Kong
In metastatic breast cancer (MBC), hormone receptor positive (HR+), human epidermal growth factor negative (HER2-) subtype accounts for the majority. With various new modalities available to prolong life span in this group of patients, the effect is distant from optimum. Prevalent strategy of treating postmenopausal HR+ HER2- MBC is application of chemotherapy (CT) after progression of disease on endocrine therapy (ET) of several lines. Generally, ET targets HR+ ingredients and CT works better with HR- tumor cells...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876130/the-potential-behavioral-and-economic-impacts-of-widespread-hmg-coa-reductase-inhibitor-statin-use
#14
Mathew H Gendle
Dyslipidemia is a common pathology throughout the industrialized world, and HMG-CoA reductase inhibitors (statins) are often administered to treat elevated lipid levels. Substantial concern has been raised regarding the aggressive clinical lowering of cholesterol, particularly in light of a growing body of research linking low circulating lipid levels with negative behavioral outcomes in both human samples and non-human primate models. In 2009, Goldstein and colleagues tentatively speculated that the greed, impulsiveness, and lack of foresight that lead to the worldwide economic collapse in 2007-2008 could have been caused (in part) by depressed population cholesterol levels resulting from the widespread use of statins by workers in the financial services industry...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876129/metabolic-syndrome-a-truly-psychosomatic-disorder-a-global-hypothesis
#15
Shrikant Madhukar Ghike
Exact cause of the metabolic syndrome [MS], a global epidemic, is still unclear. Man has same fundamental needs to live as animals but modern man's life-style compels him to acquire certainty of resources for all his needs in a complex social network. Today money has become the sole life essential need. Contrarily none of the animals needs to earn money. Brain is also an organ of the human body with a unique thought process to define logical actions to achieve a person's goals. This way life is a flow of desires followed by logical actions...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876128/can-subphysiological-cold-application-be-utilized-in-excessive-dermal-scarring-prophylaxis-and-treatment-a-promising-hypothetical-perspective
#16
Çağlayan Yağmur, Murat Sinan Engin, Rei Ogawa
Excessive dermal scarring (EDS) is a wound healing complication, characterized by protruded erythematous and inelastic 'proliferative scar tissue' which is associated with increased and prolonged inflammation process within the wound microenvironment. As inflammation plays a key role in this process, methods to contain or attenuate excessive inflammation hold promise in treatment and prophylaxis of EDS conditions. While cold exposure is notorious as the causative agent a wide array of morbidities and fatalities, its tempered use is exploited in medicine for ablative and therapeutic applications...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876127/in-silico-prediction-of-specific-pathways-that-regulate-mesangial-cell-proliferation-in-iga-nephropathy
#17
Elham Sadat Mirfazeli, Sayed-Amir Marashi, Shiva Kalantari
IgA nephropathy is one of the most common forms of primary glomerulonephritis worldwide leading to end-stage renal disease. Proliferation of mesangial cells, i.e., the multifunctional cells located in the intracapillary region of glomeruli, after IgA- dominant immune deposition is the major histologic feature in IgA nephropathy. In spite of several studies on molecular basis of proliferation in these cells, specific pathways responsible for regulation of proliferation are still to be discovered. In this study, we predicted a specific signaling pathway started from transferrin receptor (TFRC), a specific IgA1 receptor on mesangial cells, toward a set of proliferation-related proteins...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#18
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876125/is-there-a-relationship-between-sinusitis-and-psychological-disorders
#19
LETTER
Mohammad Reza Mehri, Zohre Feyzabadi
Chronic rhinosinusitis refers to inflammation of the nasal and sinuses mucosa and the main criteria for diagnosis of this disease related to the nasal cavity or the facial area. According to several reports based on the relationship of this disease with mental disorders, psychological issues are missing in the criteria of chronic rhinosinusitis diagnosis. In this study the etiology and clinical symptoms of the disease were studied by searching scientific databases and authentic Iranian Medicine books such as Avicenna's book The Canon of Medicine (Al-Qanun fi't-Tibb) that now taught in medicine schools of the Traditional East Asian; the results of this study showed that rhinosinusitis accompaniment with psychological symptoms are listed in abundance not only in old books but also in scientific literature before 1928 but after the discovery of antibiotics and extreme attention in the context of physiopathological assignment of diseases to pathogens, this relationship has been weakened...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27876124/estimating-the-influence-of-aortic-stent-grafts-after-endovascular-aneurysm-repair-are-we-missing-something
#20
Efstratios Georgakarakos
The implantation of a stiff aortic endograft for endovascular abdominal aneurysm repair (EVAR) has been reported to increase aortic stiffness and pulse wave velocity (PWV), raising potential concern over deterioration of myocardial performance. Yet, additional stiffness indices such as the augmentation index (AIx), reflection magnitude (RM) and changes in augmentation pressure (AP) have not been studied adequately to facilitate and improve our knowledge regarding the ways that EVAR affects central hemodynamics...
December 2016: Medical Hypotheses
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