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Medical Hypotheses

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https://www.readbyqxmd.com/read/28351501/hypothesis-a-perfect-day-conveys-internal-time
#1
J V Groß, L Fritschi, T C Erren
In 2007 the International Agency for Research on Cancer [IARC] concluded "shift work that involves circadian disruption is probably carcinogenic to humans" (Group 2A). To investigate the "probable" causal link, information on individual chronobiology is needed to specify exposures to circadian disruption associated with shift work. In epidemiological studies this information is usually assessed by questionnaire. The most widely used Morningness-Eveningness-Questionnaire (MEQ) and MunichChronoTypeQuestionnaire (MCTQ) reveal information on circadian type (MEQ) and actual sleep behaviour (MCTQ)...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351500/stream-of-consciousness-quantum-and-biochemical-assumptions-regarding-psychopathology
#2
Lucio Tonello, Massimo Cocchi, Fabio Gabrielli, Jack A Tuszynski
The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousness seem to offer a profound change to the current approaches. Unfortunately these quantum paradigms harbor at least two serious problems. First, they are simply models, theories, and assumptions, with no convincing experiments supporting their claims...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351499/retina-tissue-engineering-by-conjunctiva-mesenchymal-stem-cells-encapsulated-in-fibrin-gel-hypotheses-on-novel-approach-to-retinal-diseases-treatment
#3
Mostafa Soleimannejad, Somayeh Ebrahimi-Barough, Samad Nadri, Mohammad Riazi-Esfahani, Masoud Soleimani, Seyed Mohammad Tavangar, Jafar Ai
BACKGROUND: Retinitis pigmentosa (RP) and age related macular degeneration (AMD) are two retinal diseases that progress by photoreceptor cells death. In retinal transplantation studies, stem and progenitor cells inject into the sub retinal space or vitreous and then these cells can be migrate to the site of retinal degeneration and locate in the host retina and restitute vision. PRESENTATION OF THE HYPOTHESIS: Our hypothesis suggests that using human conjunctiva stem cells (as the source for increasing the number of human stem cells progenitor cells in retina dysfunction diseases) with fibrin gel and also assessing its relating in vitro (cellular and molecular processes) and in vivo (vision tests and pathology) could be a promising strategy for treatment of AMD and RP disorders...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351498/iron-accumulation-glutathione-depletion-and-lipid-peroxidation-must-occur-simultaneously-during-ferroptosis-and-are-mutually-amplifying-events
#4
Robert L Bertrand
Ferroptosis is a recently discovered form of regulated necrosis that involves iron-dependent lipid peroxidation. How cells die once ferroptosis is triggered remains unclear. Ferroptosis is hypothesized to require three critical events: (1) accumulation of redox-active iron, (2) glutathione depletion, and (3) lipid peroxidation. It is proposed that these three events must unfold simultaneously because stopping any critical event also stops ferroptosis. These events are hypothesized to amplify in severity through positive feedback loops...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351497/a-preferential-delivery-method-to-investigate-direct-neuromuscular-blockade-effect-of-inhaled-anesthetics-on-skeletal-muscle
#5
Ling Ye, Pingliang Yang
Inhaled anesthetics can enhance the effect of neuromuscular blocker, but whether inhaled anesthetics such as sevoflurane have a direct effect on skeletal muscle contractility is unknown. Selectively blocking skeletal muscle may prevent the interference effect of central nervous system. So we decided to evaluate a local application of neuromuscular blocker (NMB) atracurium to prevent the general effect on skeletal muscle. In part 1, sevoflurane (a inhaled anesthetic) minimum alveolar concentrations (MAC) of 1...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351496/a-new-in-vivo-method-to-retard-progression-of-intervertebral-disc-degeneration-through-stimulation-of-endogenous-stem-cells-with-simvastatin
#6
Zenan Huang, Liang Zhang, Xinmin Feng, Tao Chen, Songchao Bi
Degenerative disc disease is a worldwide problem, however, conservative treatment and surgical treatment can only partly relieve symptoms, but do not have therapeutic effect on the degenerated intervertebral disc (IVD) itself. The use of stem cell transplantation has become one of the most popular treatments. With gradually understanding of the endogenous mechanism of stem cells migration and movement in vivo, endogenous IVD stem cells can be activated to repair and reconstruct the degenerated IVD. Nucleus pulposus mensenchymal stem cells exhibit more potent biological activity in the hypoxic environment of the IVD...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351495/ethical-considerations-in-providing-an-upper-limb-exoskeleton-device-for-stroke-patients
#7
Adriana E Bulboacă, Sorana D Bolboacă, Angelo C Bulboacă
The health care system needs to face new and advanced medical technologies that can improve the patients' quality of life by replacing lost or decreased functions. In stroke patients, the disabilities that follow cerebral lesions may impair the mandatory daily activities of an independent life. These activities are dependent mostly on the patient's upper limb function so that they can carry out most of the common activities associated with a normal life. Therefore, an upper limb exoskeleton device for stroke patients can contribute a real improvement of quality of their life...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351494/perfusion-computed-tomography-imaging-of-abdominal-aortic-aneurysms-may-be-of-value-for-patient-specific-rupture-risk-estimation
#8
Nikolaos Kontopodis, Nikolaos Galanakis, Dimitrios Tsetis, Christos V Ioannou
Abdominal aortic aneurysm (AAA) continues to pose a significant cause of unexpected mortality in the developed countries with its incidence constantly rising. The indication of elective surgical repair is currently based on the maximum diameter and growth rate criteria which represent an oversimplification of the Law of Laplace stating that the stress exerted in a cylinder or sphere is proportional to its radius. These criteria fail to capture the complex pathophysiology of the aneurismal disease thus often leading to therapeutic inaccuracies (treating large AAAs with a very low actual rupture risk while observing smaller ones with a much greater risk)...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351493/social-death-melancholia-and-zombies-same-patterns
#9
LETTER
P Charlier, S Deo, J Hassin, C Hervé
No abstract text is available yet for this article.
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351492/prevalence-of-sleep-bruxism-and-awake-bruxism-in-different-chronotype-profiles-hypothesis-of-an-association
#10
J M Serra-Negra, F Lobbezoo, C C Martins, E Stellini, D Manfredini
Sleep (SB) and awake bruxism (AB) recognize a multifactorial etiology and have a relationship with several psychological factors. Psychological disorders have recently been associated also with the chronotype, which is the propensity for an individual to be especially active at a particular time during a 24-h period. Based on the chronotype, the two extreme profiles are morningness and eveningness individuals. Due to the relationship that both the chronotype and bruxism have with psychological factors and the fact that performing tasks not compatible with chronotype can trigger stress, this review presents the hypothesis that the prevalence of SB and AB can differ with the various chronotype profiles...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351491/vegf-inhibition-as-possible-therapy-in-spondyloarthritis-patients-targeting-bone-remodelling
#11
Alexis Lacout, Robert Yves Carlier, Mostafa El Hajjam, Pierre Yves Marcy
Spondyloarthritis refers to a group of chronic inflammatory rheumatic diseases that predominantly affects the axial skeleton, causing pain and stiffness. Human bone is highly dynamic organ that interacts with a wide array cells and tissues. Process of bone remodelling relies on a delicate balance between bone formation and bone resorption, orchestrated by osteoblasts and osteoclasts. Disruption of this homeostatic balance of bone removal and replacement can manifest as inappropriate new bone formation found in spondylarthritis...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351490/high-meniscal-slope-angle-as-a-risk-factor-for-meniscal-allograft-extrusion
#12
P Łuczkiewicz, K Daszkiewicz, J Chróścielewski, W Witkowski, L Kuik
A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allograft transplantation. Because a meniscal extrusion is associated with a cartilage deterioration and the progression of osteoarthritis there is a great interest in how to prevent this phenomenon...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351489/dying-for-love-perimenopausal-degeneration-of-vaginal-microbiome-drives-the-chronic-inflammation-malignant-transformation-of-benign-prostatic-hyperplasia-to-prostatic-adenocarcinoma
#13
Albert Stuart Reece
Prostatic carcinoma is the second commonest cancer in males and is so common as to become almost holoendemic with advancing age. The recent demonstration that far from being benign, "benign" prostatic hypertrophy is a likely a reaction of the prostate to chronic untreated lower genital tract infection, and that this chronic inflammation is likely the usual precursor to the frequent occurrence of prostatic carcinoma has far reaching implications. The obvious source for the chronic inflammatory stimulus in the prostate is the documented dramatically altered lower female genital microbiota associated with the menopause...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351488/investigating-the-effect-of-external-trauma-through-a-dynamic-system-modeling-approach-for-clustering-causality-in-diabetic-foot-ulcer-development
#14
Parisa Salimi, Mohsen Hamedi, Nima Jamshidi, Milad Vismeh
Diabetes and its associated complications are realized as one of the most challenging medical conditions threatening more than 29 million people only in the USA. The forecasts suggest a suffering of more than half a billion worldwide by 2030. Amid all diabetic complications, diabetic foot ulcer (DFU) has attracted much scientific investigations to lead to a better management of this disease. In this paper, a system thinking methodology is adopted to investigate the dynamic nature of the ulceration. The causal loop diagram as a tool is utilized to illustrate the well-researched relations and interrelations between causes of the DFU...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351487/viremic-attack-explains-the-dual-hit-theory-of-parkinson-s-disease
#15
Isamu Mori
The dual-hit theory of Parkinson's disease proposes that an airborne pathogen attacks both the olfactory and enteric nervous systems to initiate the Lewy pathology, gradually leading to devastating neurodegenerative processes within the brain. Based on published literatures, this article proposes a hypothesis that viruses with viremic potential can simultaneously attack both of these nervous systems via viremia due to the lack of a blood-nerve barrier in these tissues, thereby explaining the dual-hit theory...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351486/potential-usefulness-of-diastolic-parameters-measured-by-strain-imaging-echocardiography-in-the-early-prediction-of-chemotherapy-induced-cardiotoxicity
#16
Dagmar F Hernandez-Suarez, Angel López-Candales
Over the past decades, chemotherapy has significantly increased the overall prognosis and survival of several patients diagnosed with cancer. However, the usefulness of some chemotherapeutic agents has been hindered by a collateral dose-dependent cardiotoxicity. To date, although extensive efforts have been directed to the early detection of subclinical toxicity in patients treated with these drugs, it remains unclear which approach would be best in order to prevent chemotherapy-induced cardiotoxicity (CIC)...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351485/a-new-proposition-for-the-screening-of-platelet-function-defects-using-an-hematology-analyzer
#17
Mohammed Nazim Bennaoum, Hassiba Lazreg, Affaf Adda, Mohamed Hammadi
In this paper we suggest a new method for the screening of congenital thrombopathies using an hematology analyzer. This method is an improvement of the platelet count ratio principle which uses an impedance counter to search a decrease of the free platelet count after adding platelet agonist to whole blood. We suggest using novel platelet parameters provided by an optical hematology analyzer such as ADVIA 2120i (Siemens Healthcare Diagnostics) to search morphological and structural changes of platelet that are supposed reflecting platelet activation in normal platelets after addition of an agonist...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351484/hypocapnic-hypothesis-of-leigh-disease
#18
Ewa Pronicka
Leigh syndrome (LS) is a neurogenetic disorder of children caused by mutations in at least 75 genes which impair mitochondrial bioenergetics. The changes have typical localization in basal ganglia and brainstem, and typical histological picture of spongiform appearance, vascular proliferation and gliosis. ATP deprivation, free radicals and lactate accumulation are suspected to be the causes. Hypocapnic hypothesis proposed in the paper questions the energy deprivation as the mechanism of LS. We assume that the primary harmful factor is hypocapnia (decrease in pCO2) and respiratory alkalosis (increase in pH) due to hyperventilation, permanent or in response to stress...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351483/surface-modified-nano-lipid-drug-conjugates-of-positive-allosteric-modulators-of-m1-muscarinic-acetylcholine-receptor-for-the-treatment-of-alzheimer-s-disease
#19
Pavan Kumar Chintamaneni, Praveen T Krishnamurthy, Pachava Vengal Rao, SaiKiran S S Pindiprolu
Acetyl Cholinesterase (AChE) inhibitors such as Donepezil, Rivastigmine and Galantamine are approved by US-FDA as first line drugs to treat the cognitive symptoms of Alzheimer's disease (AD). Their beneficial effects are attributed to their ability to elevate endogenous acetylcholine (ACh) at the M1 muscarinic receptor in the brain. However, their side effects such as nausea, vomiting, dizziness, insomnia, loss of appetite and altered heart rate are related to non-specific activation of M2-M5 muscarinic subtypes in various tissues...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28351482/fermi-pasta-ulam-auto-recurrence-in-the-description-of-the-electrical-activity-of-the-heart
#20
M A Novopashin, A V Shmid, A A Berezin
The authors proposed and mathematically described model of a new type of the Fermi-Pasta-Ulam recurrence (the FPU auto recurrence) and hypothesized an adequate description of the heart's electrical dynamics within the observed phenomenon. The dynamics of the FPU auto recurrence making appropriate electrical dynamics of the normal functioning of the heart in the form of an electrocardiogram (ECG) was obtained by a computer model study. The model solutions in the form of the FPU auto recurrence - ECG Fourier spectrum were evaluated for resistance to external disturbances in the form of random effects, as well as periodic perturbation at a frequency close to the heart beating rate of about 1Hz...
April 2017: Medical Hypotheses
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