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Medical Hypotheses

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https://www.readbyqxmd.com/read/29447943/novel-mutant-of-escherichia-coli-asparaginase-ii-to-reduction-of-the-glutaminase-activity-in-treatment-of-acute-lymphocytic-leukemia-by-molecular-dynamics-simulations-and-qm-mm-studies
#1
Noeman Ardalan, Sako Mirzaie, Abbas Akhavan Sepahi, Ramazan Ali Khavari-Nejad
L-Asparaginases (ASNase) belong to a family of amidohydrolases, have both asparaginase and glutaminase activity. Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. Bacterial ASNase has been used for the treatment of ALL. Glutaminase activity of enzyme causes some side effect and it is not essential for anticancer activity. The aim of this study was engineering of Escherichia coli asparaginase II to find a mutant with reduced glutaminase activity by molecular docking, molecular dynamics (MD) and QM-MM (Quantum mechanics molecular dynamics) simulations...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447942/pathogenesis-of-idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-irvan-or-idiopathic-retinal-arteriolar-aneurysms-iraa-with-macular-star
#2
LETTER
https://www.readbyqxmd.com/read/29447941/eliminated-respiration-coupled-oscillations-in-the-brain-as-a-possible-link-between-adenotonsillar-hypertrophy-and-cognitive-impairment
#3
LETTER
Farhad Tabasi, Mohammad Reza Raoufy
No abstract text is available yet for this article.
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447940/the-relationship-between-plasma-vascular-endothelial-growth-factor-and-erythrocyte-2-3-bisphosphoglycerate-the-putative-role-of-chronic-hypoxia
#4
B K Puri, J A Monro
The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hypoxia. Arterial blood oxygen measurement is invasive and often does not give a good indication of the level of tissue hypoxia. Other suggested methods include the use of positron emission tomography, magnetic resonance T2 ∗ relaxation time measurement, photoacoustics and high-frequency ultrasound...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447939/the-cardiovascular-robustness-hypothesis-unmasking-young-adults-hidden-risk-for-premature-cardiovascular-death
#5
Lutz E Kraushaar, Alexander Dressel
An undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor levels is an acknowledged obstacle to CVD prevention. In this paper, we present the hypothesis that the vasculature's robustness against risk factor load will complement conventional risk factor models as a novel stratifier of risk. Figuratively speaking, mortality risk prediction without robustness scoring is akin to predicting the breaking risk of a lake's ice sheet considering load only while disregarding the sheet's bearing strength...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447938/hypothesis-is-there-a-link-between-the-immune-response-to-human-herpes-virus-type-6%C3%AE-hhv-6%C3%AE-infection-and-the-interaction-network-interactome-of-the-genes-encoding-the-ctss-ptx3-chi3l1-mx1-cxcl16-birc3-and-bst2-proteins
#6
Erasmia Rouka
Human Herpes Virus type 6 (HHV-6) is a ubiquitous virus consisting of two viral species, HHV-6A and HHV-6B that have been associated with numerous and diverse pathologies. As many other viruses HHV-6 modulates the apoptotic machinery of its host to subvert immune response to infection, yet the exact mechanisms behind this process remain under investigation. The genes encoding the CTSS, PTX3, CHI3L1, Mx1, CXCL16, BIRC3 and BST2 proteins have been linked to HHV-6Α related neurologic diseases whilst also associated with apoptosis...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447937/splenectomy-may-have-more-complications-than-currently-proven
#7
Somayeh Zakeri, Narjes Gorji, Marjan Akhtari, Reihaneh Moeini
The spleen has been one of the least understood major organs for centuries. Its significance is relatively well-known today but it seems that all aspects of its activities are not fully understood. Persian medicine (PM) has special views on the function of spleen; many side effects were reported in PM due to spleen dysfunction. On the other hand nowadays splenectomy as a treatment strategy is recommended for some disorders and increasing risk of infections is considered as the most important long term side effect of that...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447936/inducing-hypertrophic-effects-of-type-i-skeletal-muscle-fibers-a-hypothetical-role-of-time-under-load-in-resistance-training-aimed-at-muscular-hypertrophy
#8
Jozo Grgic, Jan Homolak, Pavle Mikulic, Javier Botella, Brad J Schoenfeld
An emerging body of evidence is starting to suggest that the hypertrophy of skeletal muscle fibers might be load specific. In other words, it may be that resistance training with high loads (i.e., ≥60% of 1 repetition maximum [RM]) emphasizes a greater growth of type II muscle fibers, while resistance training with low loads (i.e., <60% of 1RM) might primarily augment hypertrophy of type I muscle fibers. Type I and type II muscle fibers possess certain distinct characteristics, with type II muscle fibers having faster calcium kinetics, faster shortening velocities, and ability to generate more power than type I muscle fibers...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447935/biofilms-busters-to-improve-the-detection-of-borrelia-using-pcr
#9
Alexis Lacout, Véronique Dacher, Mostafa El Hajjam, Pierre Yves Marcy, Christian Perronne
Lyme disease is an affection caused by a spirochete infection called Borrelia Burgdorferi which may harbor a varied and misleading clinical symptomatology. The serology tests commonly used for diagnosis show a wide sensitivity varying from 34% to 70,5%, leaving many infected patients with false negative tests. Alternative techniques such as polymerase chain reaction (PCR) could be helpful but not conclusive enough. Using biofilm busters, such as stevia and serratiopeptidase, could lead to bacterial blood release, thus increasing the spirochete load, making PCR test more sensitive, thus improving the patient's diagnosis and management...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447934/mismatch-between-gluts-and-glucose-levels-causes-neuronal-damage-during-glucose-fluctuations
#10
Zhichao Xie, Jun Guo, Yan Kang, Xiaofeng Ou
Abnormal glucose levels damage the central nervous system, especially in case of rapid fluctuations. Even a single episode of glucose reperfusion can result in overt impairment of neurons. Oxidative stress plays an important role in this process, sharing properties with the pathophysiologic changes of glucose neurotoxicity. Glucose transporters (GLUTs) located in the brain are involved in direct glucose uptake by neurons. Instead of being insulin-sensitive, these transporters are regulated by glucose levels in the extracellular fluid, increasing their expression while glucose levels fall, to absorb more glucose...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447933/ultrasound-guided-percutaneous-electrolysis-a-new-therapeutic-option-for-mammary-fistulas
#11
Juan D Berná-Serna, José A García-Vidal, Pilar Escolar-Reina, Juan D Berná-Mestre
Mammary fistula (MF) is a recurrent condition characterised by the draining of abscesses around the areola. The best management for MF remains challenging. Moreover, the main problem is the high recurrence rate of this disease. MF is considered a chronic process. The percutaneous electrolysis (PE) technique involves the application of a galvanic current with an ultrasound-guided needle to induce ablation and repair of the affected tissue. Good results have been obtained with PE in chronic tendinopathies. Below we present a hypothesis that PE may be a new therapeutic option for MF...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447932/determining-the-venous-oxygen-reservoir-a-novel-hypothetical-approach-to-titration-of-supplemental-oxygen-in-preterm-newborns
#12
Chad C Andersen, Nicolette A Hodyl, Nina M Ziegler, Michael J Stark
While normal oxygen saturation is commonly thought to be a marker of normal oxygenation, cutaneous saturation does not account for the sufficiency of oxygen within each cell or that of the system overall. Rather, cutaneous oximetry simply defines the saturation of haemoglobin (Hb) with oxygen in a pulsatile vessel. Assessment of sufficiency is best determined by measurement of the amount of oxygen left over following aerobic respiration. This left over oxygen is 'stored' on Hb in the venous compartment and can be calculated as the venous oxygen content...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447931/impulsive-mechanisms-influencing-relapse-in-alcohol-drinking
#13
Hugo E Reyes-Huerta, Cristiano Dos Santos, Kalina Martínez
Impulsivity has been related to different features of addictive behaviors. Growing data, generated in separated lines of research, suggest that different processes underlying impulsivity are associated to relapse in alcohol drinking. Considering the evidence, relapse can be understood as an impulsive choice or as an impulsive action. In the first case, the return to drinking behavior is a consequence of insensitive to delayed consequence, that is, to the discounting of delayed rewards. In the second case, relapse is a consequence of failures to inhibit prepotent responses...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447930/linked-help-from-bacterial-proteins-drives-autoantibody-production-in-small-vessel-vasculitis
#14
David B G Oliveira
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The recent finding that S. aureus produces proteins that bind tightly to and block the function of both PR3 and MPO suggests a mechanism for ANCA formation. The bacterial protein-autoantigen conjugate is recognised by B cells with ANCA specificity, internalised, and the bacterial protein processed and presented to T cells with specificity for bacterial peptides...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447929/a-complex-systems-approach-to-cancer-prevention
#15
P W Jupp
Cancer incidence continues to be a major health problem possibly because cancer is a complex system comprising many agents that interact in a non-linear manner resulting in many possible outcomes. The degree of complexity of a cancer system could be vast involving multiple endogenous and exogenous agents interacting with the over 10 trillion cells comprising the body. It is hypothesized that the practical management of this complexity may be a key to cancer prevention and possibly treatment. But the management and resolution of such an immensely complex system is difficult and may require a multidisciplinary approach including physics, biology, biochemistry and medical science...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447928/the-use-of-polysulfated-polysaccharides-heparin-like-compounds-glycosaminoglycans-and-vitamin-b17-as-a-possible-treatment-for-prostate-cancer
#16
Jamil Hantash
Prostate cancer is impacting many men globally. It is a disease that has no effective treatment is available in the market. The understanding of the biophysical and biochemical aspects of the disease and the mechanism that allow it to metastasize is key to finding an effect treatment. Maintenance or pretreatment drug as well as a post treatment drug can be effective to avoid or delay the disease from appearing. The polysaccharides and monosaccharides polymers combined with vitamins can be the ingredient to developing the treatment...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29407005/would-glucagon-like-peptide-1-receptor-agonists-have-efficacy-in-binge-eating-disorder-and-bulimia-nervosa-a-review-of-the-current-literature
#17
Susan L McElroy, Nicole Mori, Anna I Guerdjikova, Paul E Keck
Binge eating, eating an abnormally large amount of food in a discrete period of time with a sense of loss of control over eating, is a defining feature of the eating disorders binge eating disorder (BED) and bulimia nervosa (BN). Both BED and BN are important public health problems for which there are few medical treatments. However, almost all drugs with central nervous system-mediated weight loss properties studied thus far in randomized, placebo-controlled trials in persons with BED or BN have been efficacious for reducing binge eating behavior...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29407004/breast-milk-is-conditionally-perfect
#18
Miriam Erick
Breast milk is the universal preferred nutrition for the newborn human infant. New mother have been encouraged to exclusively breastfeed by health care professionals and consumer-advocacy forums for years, citing "breast milk is the perfect food". The benefits are numerous and include psychological, convenience, economical, ecological and nutritionally superior. Human milk is a composite of nutritional choices of the mother, commencing in the pre-conceptual era. Events influencing the eventual nutritional profile of breast milk for the neonate start with pre-conceptual dietary habits through pregnancy and finally to postpartum...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29407003/no-incision-and-tension-free-vaginal-sling-for-stress-urinary-incontinence-the-role-of-knotless-barbed-suture
#19
Qiang Niu, Jinping Zheng, Xiaohui Han
Midurethral mesh sling is the most performed incontinence procedure. This hypotheses propose knotless barbed suture could be positioned as a tension-free trans-vaginal sling under the mid-urethra without vaginal incision. Knotless suture sling support and stabilize mid-urethra when intraabdominal pressure increase. This procedure is designed to replace midurethral mesh sling operation, aiming at reducing complications. It is completed in a similar way with retropubic mesh sling procedure, and less invasive...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29407002/a-hypothetical-pathogenesis-model-for-androgenic-alopecia-clarifying-the-dihydrotestosterone-paradox-and-rate-limiting-recovery-factors
#20
Robert S English
Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence and extensive study, a coherent pathology model describing androgenic alopecia's precursors, biological step-processes, and physiological responses does not yet exist. While consensus is that androgenic alopecia is genetic and androgen-mediated by dihydrotestosterone, questions remain regarding dihydrotestosterone's exact role in androgenic alopecia onset...
February 2018: Medical Hypotheses
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