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Medical Hypotheses

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https://www.readbyqxmd.com/read/28110705/creating-dynamic-virtual-quarantines-using-pok%C3%A3-mon-go-to-limit-infectious-diseases-spread
#1
LETTER
Martijn R Tannemaat, N Ahmad Aziz
No abstract text is available yet for this article.
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110704/dimorphic-placental-stress-a-repercussion-of-interaction-between-endocrine-disrupting-chemicals-edcs-and-fetal-sex
#2
Surbhi Sood, Sudhanshu Shekhar, Winkins Santosh
Placental homeostasis is critical for fetal development as it determines the health of mother and fetus during pregnancy and in later life. Interestingly even the fetus, in a sexually dimorphic manner, influences the pedantic growth and development of placenta. Although placenta is thought to act as a protective barrier against chemical exposures, certain endocrine disrupting chemicals (EDCs) that are circulating in mother's blood tend to cross placenta. These EDCs have been reported to cause changes in expression levels of certain genes, immunogenic factors and non-coding RNAs such as micro RNA (miRNA) and long non-coding RNA (lncRNA) leading to placental stress...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110703/plant-based-diets-relatively-low-in-bioavailable-phosphate-and-calcium-may-aid-prevention-and-control-of-prostate-cancer-by-lessening-production-of-fibroblast-growth-factor-23
#3
Mark F McCarty
Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers. In some of these cancers, autocrine production of FGF23 drives their proliferation. FGF23 synthesized within bone likely promotes the expansion of prostate cancer bone metastases. Hence, dietary or lifestyle factors which boost bone's production of FGF23 may encourage the induction and spread of prostate cancer...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110702/use-of-nanoparticles-with-escherichia-coli-receptors-for-prophylaxis-of-recurrent-urinary-tract-infections-in-children
#4
LETTER
Ilke Beyitler, Salih Kavukcu
No abstract text is available yet for this article.
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110701/potential-relationship-between-periodontal-diseases-and-eye-diseases
#5
Z A D Pockpa, X Struillou, N T Coulibaly, M Weber, A Soueidan, Z Badran
Periodontal diseases are inflammatory lesions initiated by oral bacteria and lead to the destruction of the supporting structures of the teeth (gingiva, periodontal ligament and alveolar bone) in susceptible patient. Via several biological mechanisms, periodontal diseases have been associated with multiple systemic diseases, such as rheumatoid arthritis, diabetes, cardiovascular diseases, Alzheimer's disease and adverse pregnancy outcomes. Similarly certain eye diseases have been associated with systemic diseases of the inflammatory pathway...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110700/huperzine-a-a-promising-anticonvulsant-disease-modifying-and-memory-enhancing-treatment-option-in-alzheimer-s-disease
#6
Ugur Damar, Roman Gersner, Joshua T Johnstone, Steven Schachter, Alexander Rotenberg
Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction and increase the risk of falls. On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110699/high-concentration-topical-capsaicin-may-abolish-the-clinical-manifestations-of-allergic-contact-dermatitis-by-effects-on-induction-and-elicitation
#7
Hjalte H Andersen, Jesper Elberling, Lars Arendt-Nielsen
Allergic contact dermatitis (ACD) is a common skin condition caused by a type-IV hypersensitivity reaction. Even though ACD is considered as a T-cell mediated disease, indications exists that peptidergic nerve fibers at the site of allergen exposure and associated with the draining lymph node play a prominent role in both induction and elicitation of ACD. This neuro-immune cross talk seems rely on neuropeptides such as Substance P secreted by nerve fiber terminals. It is hypothesized that local complete or partial cutaneous denervation/defunctionalization of peptidergic fibers in humans could be a feasible approach towards treating allergic contact dermatitis...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110698/heart-rate-variability-regression-and-risk-of-sudden-unexpected-death-in-epilepsy
#8
Alessio Galli, Federico Lombardi
The exact mechanisms of sudden unexpected death in epilepsy remain elusive, despite there is consensus that SUDEP is associated with severe derangements in the autonomic control to vital functions as breathing and heart rate regulation. Heart rate variability (HRV) has been advocated as biomarker of autonomic control to the heart. Cardiac dysautonomia has been found in diseases where other branches of the autonomous nervous system are damaged, as Parkinson disease and multiple system atrophy. In this perspective, an impaired HRV not only is a risk factor for sudden cardiac death mediated by arrhythmias, but also a potential biomarker for monitoring a progressive decline of the autonomous nervous system...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110697/vogt-koyanagi-harada-syndrome-and-hyperhomocysteinemia-is-there-a-hidden-link
#9
LETTER
Omer Ć Ibrahimagić, Dževdet Smajlović, Zikrija Dostović, Jasmin Zvorničanin, Zejneba Pašić, Denisa Salihović Hajdarević
No abstract text is available yet for this article.
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110696/serum-insulin-in-pathogenesis-and-treatment-of-osteoarthritis
#10
Alireza Askari, Elham Ehrampoush, Reza Homayounfar, Ehsan Bahramali, Mojtaba Farjam
Osteoarthritis (OA) is one of the major health problems that's development and progression is obesity-related. We believe that higher levels of insulin may explains this link especially. High levels of insulin in obesity and metabolic syndrome can induce numerous complications. Insulin can increase proliferation of chondrocyte but simultaneously, it prevents their differentiation. Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110695/men1-and-micrornas-the-link-between-sporadic-pituitary-parathyroid-and-adrenocortical-tumors
#11
Z Nagy, P M Szabó, V K Grolmusz, P Perge, I Igaz, A Patócs, P Igaz
Sporadic tumors of the pituitary, parathyroids and adrenal cortex are unique, as their benign forms are very common, but malignant forms are exceptionally rare. Hereditary forms of these tumors occur in multiple endocrine neoplasia syndrome type 1 (MEN1). We hypothesize that the pathogenic link among the sporadic tumors of these organs of different germ layers might be represented by common molecular pathways involving the MEN1 gene and microRNAs (miR). miR-24 might be a microRNA linking the three tumor entities, but other candidates such as miR-142-3p and microRNAs forming the DLK1-MEG3 miRNA cluster might also be of importance...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110694/tourette-syndrome-in-the-context-of-evolution-and-behavioral-ecology
#12
Jared Edward Reser
Tourette syndrome, and the closely related spectrum of tic disorders, are inherited neuropsychiatric conditions characterized by the presence of repetitive and stereotyped movements. Tics are elicited by either environmental experiences or internal signals that instruct the basal ganglia to initiate automatic or procedural movements. In most vertebrates the basal ganglia encode instructions for habitually used sequences of motor movements that are essential to survival. Tic disorders may represent evolved phenotypes with a lower threshold for basal ganglia-directed actions...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110693/could-calprotectin-and-endocan-serve-as-troponin-of-nephrologists
#13
Arsalan Azimi
AKI, a serious, common and occasionally under-recognized condition, which is a significant contributor to the growing incidence of CKD and end-stage renal disease (ESRD). To date, the diagnosis of AKI is made by serial measurement of Cr and BUN which are late and imprecise markers of kidney injury. "Calprotectin" and "endocan" are two biomarkers that could reflect renal tubular injury and glomerular/endothelial-vascular damage, respectively. Measurement of urinary calprotectin could help the physicians to diagnose tubular degradation and differentiate prerenal AKI from intrinsic AKI...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110692/are-linear-achr-epitopes-the-real-culprit-in-ocular-myasthenia-gravis
#14
LETTER
Xiaorong Wu, Erdem Tüzün
Extraocular muscle weakness occurs in most of the myasthenia gravis (MG) patients and it is often the initial complaint. Approximately 10-20% of MG patients with extraocular muscle weakness display only ocular symptoms and rest of the patients subsequently develop generalized muscle weakness. It is not entirely clear why some MG patients develop only ocular symptoms and why extraocular muscle weakness almost always precedes generalized muscle weakness. These facts are often explained by increased susceptibility of extraocular muscles due to their reduced endplate safety factor and lower complement inhibitor expression...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110691/is-insulin-growth-factor-1-the-future-for-treating-autism-spectrum-disorder-and-or-schizophrenia
#15
Rami Bou Khalil
To date, no curative psychopharmacologic treatment exists for the core symptoms of autism spectrum disorder (ASD) as well as for schizophrenia. Bumatenide is a specific antagonist of the first isoform of the Na-K-Cl cotransporter (NKCC1). It is usually used as a diuretic but may also promote a decrease in intraneuronal chloride ion concentration leading to hyperpolarization in neuronal membrane and subsequent decrease in neuronal hyperexcitability. This physiologic effect has been considered to be behind the relative efficacy of bumetanide in improving symptoms of ASD and, to a lesser extent, schizophrenia...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110690/improved-cognitive-and-memory-abilities-in-a-patient-with-alzheimer-s-disease-treated-with-activated-immune-cells-immune-cell-therapy-may-benefit-more-ad-patients
#16
B Laumbacher, B Fellerhoff-Loesch, R Wank
So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring late-onset AD of higher-aged individuals, comprising 90% of AD patients. Thorough investigations have detected a prevalence of certain microbes which are known to affect brain activities in the brains of AD patients...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110689/cannabinoids-possible-agents-for-treatment-of-psoriasis-via-suppression-of-angiogenesis-and-inflammation
#17
Amir Hossein Norooznezhad, Fatemeh Norooznezhad
Psoriasis is a chronic skin disease also affecting other sites such as joints. This disease highly depends on inflammation and angiogenesis as well as other pathways. At each step of the psoriasis molecular pathway, different inflammatory cytokines and angiogenic growth factors are involved such as hypoxia inducible factor-1 α (HIF-1 α), vascular endothelial growth factor (VEGF), matrix metalo proteinases (MMPs), basic fibroblast growth factor (bFGF), Angiopoitin-2, interleukin-8 (IL-8), IL-17, and IL-2. Beside the mentioned growth factors and cytokines, cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) which play roles in both angiogenesis and inflammation are also involved in the pathogenesis...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110688/intradialytic-creatine-supplementation-a-scientific-rationale-for-improving-the-health-and-quality-of-life-of-dialysis-patients
#18
Theo Wallimann, Uwe Riek, Michael Möddel
The CK/PCr-system, with creatine (Cr) as an energy precursor, plays a crucial role in cellular physiology. In the kidney, as in other organs and cells with high and fluctuating energy requirements, energy-charged phospho-creatine (PCr) acts as an immediate high-energy source and energy buffer, and as an intracellular energy transport vehicle. A maximally filled total Cr (Cr plus PCr) pool is a prerequisite for optimal functioning of the body and its organs, and health. Skeletal- and cardiac muscles of dialysis patients with chronic kidney disease (CKD) are depleted of Cr in parallel with the duration of dialysis...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28012613/towards-improvement-of-facilitating-the-contralateral-limb-cannulation-of-currently-available-endografts-for-the-treatment-of-abdominal-aortic-aneurysms-first-innovate-then-intervene
#19
LETTER
Efstratios Georgakarakos, George S Georgiadis
No abstract text is available yet for this article.
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28012612/paying-the-price-for-body-evolution-the-role-of-evolution-in-disorders-of-body-representation
#20
Francesca G Magnani, Anna Sedda
Since its beginning, research about cognitive representation of our bodies has debated over multiple representations models. Furthermore, recent years have seen a rise in the study of body representation disorders and related impairments. However, why human beings manifest so many deficits is still a mystery. Considering human evolution, frontal brain regions are well known for their changes in dimensions and connections. Less known is that parietal and temporal lobes encountered similar changes. These areas, especially in the right hemisphere, are crucial for body representation...
January 2017: Medical Hypotheses
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