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Journals British Journal of Clinical Ph...

British Journal of Clinical Pharmacology

https://read.qxmd.com/read/38450747/paliperidone-poisoning-and-measurable-plasma-concentrations-2-5%C3%A2-years-after-last-administered-dose-a-case-report
#21
Mariam Nersesjan, Maria Wagner, Kim Peder Dalhoff, Tonny Studsgaard Petersen, Søren Bøgevig, Henrik Horwitz
We report a poisoning with paliperidone palmitate, a once-monthly, long-acting injectable antipsychotic. The patient suffered from deep sedation and dystonia. She had been treated with extended release intramuscular paliperidone for several years and had received her last injection 8 days prior to admission. The plasma paliperidone was nearly five times higher than the upper reference range. Paliperidone is a substrate of p-glycoprotein and we therefore aimed to increase its elimination by inducing p-glycoprotein through treatment with St John's wort...
March 7, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38439592/the-relationship-of-pain-intensity-and-opioid-craving-with-delayed-methadone-dose-a-preliminary-study-of-individuals-with-opioid-use-disorder
#22
JOURNAL ARTICLE
R Ross MacLean, Suzanne Spinola, Brian Pittman, Julia Meyerovich, Sara K Szollosy, Noah R Wolkowicz, Stacy Minnix, Mehmet Sofuoglu
AIMS: Despite a strong theoretical link between opioid craving and pain, little is known about the temporal relationship between pain and craving and the acute experience of pain in the context of methadone treatment. Using a cross-over design, the current study evaluated the time course of pain and craving and objective experience of pain as a function of the last methadone dose. METHODS: Participants (n = 20) presented for the study in the morning and either received methadone dose as scheduled or delayed dose until the afternoon...
March 4, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38439145/feasibility-and-evaluation-of-high-fidelity-simulation-education-for-acute-clinical-toxicology
#23
JOURNAL ARTICLE
David J Brinkman, Nella S Wackwitz, Erik Donker, Jelle Tichelaar
To prepare medical students appropriately for the management of toxicological emergencies, we have developed a simulation-based medical education (SBME) training in acute clinical toxicology. Our aim is to report on the feasibility, evaluation and lessons learned of this training. Since 2019, each year approximately 180 fifth-year medical students are invited to participate in the SBME training. The training consists of an interactive lecture and two SBME stations. For each station, a team of students had to perform the primary assessment and management of an intoxicated patient...
March 4, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38417973/the-association-of-pain-impact-and-sleep-disruption-with-opioid-withdrawal-during-opioid-use-disorder-treatment
#24
JOURNAL ARTICLE
Jennifer D Ellis, Daniel Han, Jami Mayo, J Gregory Hobelmann, Patrick H Finan, Andrew S Huhn
AIMS: Persons with opioid-use disorder (OUD) often experience opioid withdrawal and opioid craving, which can drive continued opioid use and treatment discontinuation. In addition, hyperalgesia is common among persons with OUD, yet few studies have examined the role of pain impact during OUD treatment. The purpose of the present study was to test whether opioid withdrawal and craving were elevated in the context of greater pain impact (i.e. greater pain intensity and interference), and whether these associations changed throughout treatment...
February 28, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38408767/prevalence-of-potentially-inappropriate-medications-among-newly-treated-patients-with-type-2-diabetes-in-uk-primary-care
#25
JOURNAL ARTICLE
Maria Luisa Faquetti, Géraldine Frey, Dominik Stämpfli, Stefan Weiler, Andrea M Burden
AIMS: The aim of this study was to estimate the prevalence of potentially inappropriate prescriptions (PIPs) in patients starting their first noninsulin antidiabetic treatment (NIAD) using two explicit process measures of the appropriateness of prescribing in UK primary care, stratified by age and polypharmacy status. METHODS: A descriptive cohort study between 2016 and 2019 was conducted to assess PIPs in patients aged ≥45 years at the start of their first NIAD, stratified by age and polypharmacy status...
February 26, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38408756/effects-of-rifampicin-on-the-pharmacokinetics-and-safety-of-carotegrast-methyl-in-healthy-subjects-a-randomized-2%C3%A2-%C3%A3-%C3%A2-2-crossover-study
#26
JOURNAL ARTICLE
Hiromitsu Imai, Ichiro Oikawa, Tetsuya Koyama, Shunji Matsuki
AIMS: To evaluate the effect of the combination of carotegrast methyl with rifampicin, a potent inhibitor of organic anion transporter polypeptide, on the pharmacokinetics (PKs), safety and tolerability of carotegrast methyl. METHODS: In this 2 × 2 crossover study in 20 healthy Japanese adults, 10 subjects received carotegrast methyl 960 mg and rifampicin 600 mg on day 1 and received carotegrast methyl 960 mg on day 8. The subjects in the other sequence received the same treatments but in the opposite order...
February 26, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38403776/self-management-support-with-the-respiratory-adherence-care-enhancer-instrument-in-asthma-and-chronic-obstructive-pulmonary-disease-an-implementation-trial
#27
JOURNAL ARTICLE
Claire D Visser, Lisanne L M Antonisse, Floor M Alleda, Colin Bos, Privender Saini, Esther Kuipers, Henk-Jan Guchelaar, Martina Teichert
AIM: Suboptimal self-management with controller inhalation therapy in asthma and COPD is frequently observed with poor treatment outcomes. The developed 'Respiratory Adherence Care Enhancer' (RACE) instrument identifies and addresses individual barriers to self-management with a theoretical underpinning. This study investigates the feasibility of pharmaceutical support with this instrument. METHODS: An implementation trial was conducted with asthma and COPD patients in 5 community pharmacies in the Netherlands...
February 25, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38403473/advanced-prescription-of-injectable-anticancer-drugs-safety-assessment-in-a-european-comprehensive-cancer-centre-using-the-risk-matrix-approach
#28
JOURNAL ARTICLE
Alexandre Acramel, Sandy Blondeel-Gomes, Mathilde Dupré, Ornella Tangila Kayembe, Aude Rochereau, Laurence Escalup, Romain Desmaris, Nathalie Jourdan, Adeline Cordary, Pauline Vaflard, Paul Cottu, Audrey Bellesoeur
AIMS: The purpose of this work was to assess failures in the advanced prescription of parenteral anticancer agents in an adult day oncology care unit with more than 100 patients per day. METHODS: An a priori descriptive analysis was carried out by using the risk matrix approach. After defining the scope in a multidisciplinary meeting, we determined at each step the failure modes (FMs), their effects (E) and their associated causes (C). A severity score (S) was assigned to all effects and a probability of occurrence (O) to all causes...
February 25, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38382554/estimation-of-adherence-to-urate-lowering-therapy-in-people-living-with-gout-using-australia-s-pharmaceutical-benefits-scheme-and-patient-reported-dosing
#29
JOURNAL ARTICLE
Marcel Schulz, Matthew J Coleshill, Richard O Day, Daniel F B Wright, Jonathan Brett, Nancy E Briggs, Eindra Aung
AIMS: The aim of this study was to estimate adherence to urate-lowering therapy (ULT), predominately allopurinol, from Australia's Pharmaceutical Benefits Scheme (PBS) claims database in association with (1) patient-reported doses and (2) World Health Organization's (WHO) defined daily doses (DDD), namely, allopurinol (400 mg/day) or febuxostat (80 mg/day). METHODS: Proportion of days covered (PDC) was calculated in 108 Gout App (Gout APP) trial participants with at least two recorded ULT dispensings in an approximately 12-month period before provision of intervention or control apps...
February 21, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38373846/eculizumab-dose-tapering-should-take-into-account-the-nonlinearity-of-its-pharmacokinetics
#30
JOURNAL ARTICLE
Olivier Le Tilly, Philippe Gatault, Saida Semlali, Rebecca Sberro-Soussan, Christophe Passot, Dominique Bertrand, Céline Desvignes, Sophie Caillard, Gilles Paintaud, Jean-Michel Halimi, David Ternant
AIMS: Eculizumab is a monoclonal antibody targeting complement protein C5 used in renal diseases. As recommended dosing regimen leads to unnecessarily high concentrations in some patients, tailored dosing therapeutic drug monitoring was proposed to reduce treatment cost. The objectives of the present work were (i) to investigate the target-mediated elimination of eculizumab and (ii) whether a pharmacokinetic model integrating a nonlinear elimination allows a better prediction of eculizumab concentrations than a linear model...
February 19, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38369772/maternal-exposure-to-folate-antagonists-and-susceptibility-to-congenital-heart-disease-in-offspring-a-systematic-review-and-meta-analysis
#31
REVIEW
Prajjwol Luitel, Rukesh Yadav, Prince Mandal, Niranjan Adhikari, Sujan Paudel, Anish Mudvari
AIMS: The objective of this meta-analysis was to determine whether maternal exposure to folate antagonists is associated with increased rates of congenital heart disease in offspring. METHODS: A comprehensive search for articles in the MEDLINE (PubMed) and EMBASE databases published up to 21 August 2023 was performed. The search strategy was not limited by study design but only for articles in the English language. RESULTS: Analysis of 6 cohort studies and 5 cross-sectional studies, published between 1976 and 2020, showed significant increase in rate of congenital heart disease (odds ratio 1...
February 18, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38369687/genetic-biomarkers-of-methotrexate-response-and-safety-in-crohn-s-disease-data-from-the-spanish-eneida-registry
#32
JOURNAL ARTICLE
Juliana Salazar, Esther Garcia-Planella, Agnès Fernández-Clotet, Maria Esteve, Javier P Gisbert, David Busquets, Alfredo Lucendo, Lucía Márquez, Jordi Guardiola, María Dolores Martín-Arranz, Eva Iglesias, David Monfort, Albert Villoria, Fiorella Cañete, Olga Bell, Elena Ricart, Yamile Zabana, María Chaparro, Eugeni Domènech, Jordi Gordillo
AIMS: Methotrexate (MTX) is used to induce and maintain remission in patients with steroid-dependent Crohn's disease (CD). Despite its proven efficacy, its use is limited due to associated adverse events. Polymorphisms involving folate pathway genes might influence MTX efficacy and toxicity. We aimed to assess the impact of certain polymorphisms on the therapeutic outcomes of MTX in CD. METHODS: Patients with CD who exclusively followed MTX monotherapy and fulfilled inclusion criteria were identified from the GETECCU ENEIDA registry...
February 18, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38369619/quality-indicators-for-appropriate-in-hospital-pharmacotherapeutic-stewardship-an-international-modified-delphi-study
#33
JOURNAL ARTICLE
Rashudy F Mahomedradja, Jelle Tichelaar, Lidwine B Mokkink, Kim C E Sigaloff, Michiel A van Agtmael
AIMS: In-hospital prescribing errors may result in patient harm, such as prolonged hospitalisation and hospital (re)admission, and may be an emotional burden for the prescribers and healthcare professionals involved. Despite efforts, in-hospital prescribing errors and related harm still occur, necessitating an innovative approach. We therefore propose a novel approach, in-hospital pharmacotherapeutic stewardship (IPS). The aim of this study was to reach consensus on a set of quality indicators (QIs) as a basis for IPS...
February 18, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38359899/the-development-and-evaluation-of-dose-prediction-tools-for-allopurinol-therapy-easy-allo-tools
#34
JOURNAL ARTICLE
Daniel F B Wright, Hailemichael Z Hishe, Sophie L Stocker, Nicola Dalbeth, Anne Horne, Jill Drake, Janine Haslett, Amanda J Phipps-Green, Tony R Merriman, Lisa K Stamp
AIMS: Dose escalation at the initiation of allopurinol therapy can be protracted and resource intensive. Tools to predict the allopurinol doses required to achieve target serum urate concentrations would facilitate the implementation of more efficient dose-escalation strategies. The aim of this research was to develop and externally evaluate allopurinol dosing tools, one for use when the pre-urate-lowering therapy serum urate is known (Easy-Allo1) and one for when it is not known (Easy-Allo2)...
February 15, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38351575/bleeding-in-patients-on-concurrent-treatment-with-a-selective-serotonin-reuptake-inhibitor-ssri-and-low-dose-acetylsalicylic-acid-asa-compared-with-ssri-or-low-dose-asa-alone-a-systematic-review-and-meta-analysis
#35
REVIEW
Magnus A B Axelsson, Carina Tukukino, Naldy Parodi López, Susanna M Wallerstedt
AIMS: The aim of this study was to systematically review whether concurrent treatment with an SSRI and low-dose ASA increases the risk of bleeding compared with treatment with an SSRI alone or ASA alone. METHODS: Medline, Embase, the Cochrane Library, PsycINFO and Web of Science (from database inception to January 2023) were searched according to PICO: P = patients on treatment with an SSRI and/or low-dose ASA; I = intervention: SSRI + ASA; C = comparison: ASA or SSRI alone; O = outcomes: bleeding/major bleeding...
February 13, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38346317/economic-evaluation-of-personalized-vs-standard-dosing-of-5-fluorouracil-in-first-line-chemotherapy-for-metastatic-colorectal-cancer-in-australia
#36
JOURNAL ARTICLE
Daniel Erku, Jennifer H Martin, Michael Michael, Peter Galettis, Paul Scuffham
AIMS: Using pharmacokinetics (PK)-guided 5-fluorouracil (5-FU) for metastatic colorectal cancer (mCRC) improves overall survival (OS) and decreases toxicity, yet its value for money in the Australian setting is unknown. Our study assesses the cost-effectiveness of PK vs. body surface area (BSA) dosing of 5-FU for patients with mCRC. METHODS: We developed a semi-Markov model with four health states to compare PK-guided dosing within a FOLFOX regimen vs. BSA-guided dosing for mCRC patients from an Australian healthcare system perspective...
February 12, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38340019/physiologically-based-pharmacokinetic-modelling-of-long-acting-injectable-cabotegravir-and-rilpivirine-in-pregnancy
#37
JOURNAL ARTICLE
Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana-Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt
AIMS: Long-acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically-based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir and rilpivirine target concentrations (664 and 50 ng/mL, respectively). METHODS: An adult PBPK model was validated using clinical data of cabotegravir and rilpivirine in nonpregnant adults...
February 10, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38332645/an-artificial-intelligence-algorithm-for-co-clustering-to-help-in-pharmacovigilance-before-and-during-the-covid-19-pandemic
#38
JOURNAL ARTICLE
Alexandre Destere, Giulia Marchello, Diane Merino, Nouha Ben Othman, Alexandre O Gérard, Thibaud Lavrut, Delphine Viard, Fanny Rocher, Marco Corneli, Charles Bouveyron, Milou-Daniel Drici
AIMS: Monitoring drug safety in real-world settings is the primary aim of pharmacovigilance. Frequent adverse drug reactions (ADRs) are usually identified during drug development. Rare ones are mostly characterized through post-marketing scrutiny, increasingly with the use of data mining and disproportionality approaches, which lead to new drug safety signals. Nonetheless, waves of excessive numbers of reports, often stirred up by social media, may overwhelm and distort this process, as observed recently with levothyroxine or COVID-19 vaccines...
February 8, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38332460/determinants-of-early-change-in-serum-creatinine-after-initiation-of-dolutegravir-based-antiretroviral-therapy-in-south-africa
#39
JOURNAL ARTICLE
Rephaim Mpofu, Aida N Kawuma, Roeland E Wasmann, Godspower Akpomiemie, Nomathemba Chandiwana, Simiso Mandisa Sokhela, Michelle Moorhouse, Willem Daniel Francois Venter, Paolo Denti, Lubbe Wiesner, Frank A Post, David W Haas, Gary Maartens, Phumla Sinxadi
AIMS: Dolutegravir increases serum creatinine by inhibiting its renal tubular secretion and elimination. We investigated determinants of early changes in serum creatinine in a southern African cohort starting first-line dolutegravir-based antiretroviral therapy (ART). METHODS: We conducted a secondary analysis of data from participants in a randomized controlled trial of dolutegravir, emtricitabine and tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide fumarate (TAF) (ADVANCE, NCT03122262)...
February 8, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38321367/appropriateness-of-direct-oral-anticoagulant-prescribing-in-older-subjects-with-atrial-fibrillation-discharged-from-acute-medical-wards
#40
JOURNAL ARTICLE
Antonio De Vincentis, Luca Soraci, Elena Arena, Angela Sciacqua, Giuseppe Armentaro, Francesco Aucella, Andrea Corsonello, Filippo Aucella, Raffaele Antonelli Incalzi
AIMS: Knowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. This study aimed to evaluate the prevalence and appropriateness of DOAC prescriptions in hospitalized older subjects with AF, discharged from acute medical wards. METHODS: We analysed a cohort of 609 subjects with AF, aged ≥65 years (mean age 85 years) enrolled from 39 geriatric and nephrology wards in Italy...
February 6, 2024: British Journal of Clinical Pharmacology
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