Read by QxMD icon Read

British Journal of Clinical Pharmacology

Jinju Guk, Dongwoo Chae, Hankil Son, Joonsang Yoo, Ji Hoe Heo, Kyungsoo Park
AIMS: Recombinant tissue plasminogen activator (rt-PA) is the only first-line agent approved by the Food and Drug Administration to treat acute ischaemic stroke. However, it often causes the serious adverse event (AE) of haemorrhagic transformation. This study developed a pharmacometric model for rt-PA treatment effect and AE and, using the developed model, proposed a benefit-to-risk ratio assessment scheme as a supportive tool to optimize treatment outcome. METHODS: Data of 336 acute ischaemic stroke patients were used...
July 13, 2018: British Journal of Clinical Pharmacology
Charles Khouri, Bruno Revol, Jean-Luc Cracowski, Matthieu Roustit
No abstract text is available yet for this article.
July 12, 2018: British Journal of Clinical Pharmacology
C J Lucas, P Galettis, J Schneider
There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regarding their pharmacokinetics and pharmacodynamics to guide prescribers. Cannabis medicines contain a wide variety of chemical compounds, including the cannabinoids delta-9-tetrahydrocannabinol (THC), which is psychoactive, and the non-psychoactive cannabidiol (CBD). Cannabis use is associated with both pathological and behavioural toxicity and accordingly, is contraindicated in the context of significant psychiatric, cardiovascular, renal or hepatic illness...
July 12, 2018: British Journal of Clinical Pharmacology
Gary Tse, Leonardo Roever, Martin C S Wong, Gregory Y H Lip, Tong Liu
No abstract text is available yet for this article.
July 8, 2018: British Journal of Clinical Pharmacology
Selma Audi, Daniel R Burrage, Dagan O Lonsdale, Sarah Pontefract, Jamie J Coleman, Andrew W Hitchings, Emma H Baker
AIMS: Prescribing is a complex skill required of doctors and, increasingly, other healthcare professionals. Use of a personal formulary can help to develop this skill. In 2006-9, we developed a core list of the 100 most commonly prescribed drugs. Our aim in the present study was to update this 'starter formulary' to ensure its continued relevance for prescriber training. METHODS: We analysed large contemporary primary and secondary care datasets to identify the most frequently prescribed medicinal products...
July 5, 2018: British Journal of Clinical Pharmacology
Pier Giorgio Cojutti, Anna Candoni, Davide Lazzarotto, Nicholas Rabassi, Renato Fanin, William Hope, Federico Pea
AIM: The aim of this study was to determine clinical variables associated with posaconazole exposure among adult patients with hematological malignancies who received posaconazole tablets for prophylaxis of invasive fungal infections (IFIs). METHODS: The study population included adult patients with hematological malignancies who received posaconazole delayed-release tablets for prophylaxis of IFIs after induction chemotherapy for acute leukemia or graft-versus-host-disease (GVHD) complicating hematopoietic stem cell transplantation (HSCT) in the period January 2016 - December 2017...
July 5, 2018: British Journal of Clinical Pharmacology
Marina Simeonova, Frank de Vries, Sander Pouwels, Johanna H M Driessen, Hubert G M Leufkens, Suzanne M Cadarette, Andrea M Burden
AIMS: Domperidone is used to treat gastrointestinal symptoms in patients with Parkinson's disease (PD) and is linked to an increased risk of mortality. We sought to examine the risk of all-cause mortality associated with domperidone exposure in PD. METHODS: We conducted a cohort study using data from the Clinical Practice Research Datalink database (1987-2011). The first recorded PD diagnosis defined index date. Time-dependent Cox proportional hazards models estimated Hazard Ratio's (HRs) of all-cause mortality associated with domperidone use...
July 5, 2018: British Journal of Clinical Pharmacology
Kannan Sridharan, Reginald P Sequeira
BACKGROUND: Several antihypertensive drugs are in use for treating severe hypertension in pregnancy. The present study is a network meta-analysis comparing the efficacy and safety of these drugs. METHODS: Electronic databases were searched for randomized clinical trials comparing drugs used for treating severe hypertension in pregnancy. Number of women achieving the target blood pressure (BP) was the primary outcome. Doses required and time taken for achieving the target BP, failure rate, and incidences of maternal tachycardia, palpitation, hypotension, headache, and neonatal death and stillbirth were the secondary outcomes...
July 4, 2018: British Journal of Clinical Pharmacology
Thomas Goedecke, Daniel R Morales, Alexandra Pacurariu, Xavier Kurz
No abstract text is available yet for this article.
July 3, 2018: British Journal of Clinical Pharmacology
Valeria Avataneo, Amedeo De Nicolò, Franco Rabbia, Elisa Perlo, Jacopo Burrello, Elena Berra, Marco Pappaccogli, Jessica Cusato, Antonio D'Avolio, Giovanni Di Perri, Franco Veglio
AIMS: Arterial hypertension is an important cardiovascular risk factor. A substantial proportion of patients show resistance to antihypertensive treatment but poor adherence to medication regimens is also a significant cause of treatment failure. In this context, Therapeutic Drug Monitoring (TDM) could be useful. The objective of this study was to assess adherence to treatment in patients with resistant hypertension by TDM and to identify parameters that predict non-adherence. METHODS: Liquid chromatography tandem mass spectrometry was used to quantify a wide panel of antihypertensive drugs in human plasma to assess treatment compliance...
July 3, 2018: British Journal of Clinical Pharmacology
Seyyed-Reza Sadat-Ebrahimi, Neda Parnianfard, Nafiseh Vahed, Hossein Babaei, Morteza Ghojazadeh, Sydney Tang, Amir Azarpazhooh
PURPOSE: Lisinopril is one of the angiotensin-converting-enzyme inhibitors that is largely being administered for its off-label uses. This study aims to provide a comprehensive review of off-label uses of lisinopril to aid physicians to make evidence-based decisions. METHODS: The following bibliographic databases were searched from inception until 30 March 2017: PubMed, EMBASE, the Cochrane Library, Cochrane Central Register of Controlled Trials, Scopus, Ovid, and Proquest...
July 3, 2018: British Journal of Clinical Pharmacology
Zaipul I Md Dom, Janet K Coller, Robert P Carroll, Jonathan Tuke, Brett C McWhinney, Andrew A Somogyi, Benedetta C Sallustio
AIMS: Although therapeutic drug monitoring of plasma mycophenolic acid (MPA) concentrations has been recommended to individualise dosage in transplant recipients, little is known regarding lymphocyte concentrations of MPA, where MPA inhibits inosine monophosphate dehydrogenase (IMPDH). This study investigated the utility of measuring pre-dose MPA concentrations in peripheral blood mononuclear cells (PBMCs) (C0C ) and pre-dose IMPDH activity, as predictors of graft rejection in renal transplant recipients...
July 2, 2018: British Journal of Clinical Pharmacology
Yvonne Bonomo, José Diogo Souza, Aidan Jackson, José Alexandre S Crippa, Nadia Solowij
No abstract text is available yet for this article.
July 2, 2018: British Journal of Clinical Pharmacology
Frank Schneider, Lavi Erisson, Hooman Beygi, Margaret Bradbury, Orit Cohen-Barak, Igor D Grachev, Serge Guzy, Pippa S Loupe, Micha Levi, Mirna McDonald, Juha-Matti Savola, Spyros Papapetropoulos, William G Tracewell, Maria Velinova, Ofer Spiegelstein
AIM: SD-1077, a selectively deuterated precursor of dopamine (DA) structurally related to L-3,4-dihydroxyphenylalanine (L-DOPA), is under development for treatment of motor symptoms of Parkinson's disease. Preclinical models have shown slower metabolism of central deuterated DA. The present study investigated the peripheral pharmacokinetics (PK), metabolism and safety of SD-1077. METHODS: Plasma and urine PK of drug and metabolites and safety after a single oral 150 mg SD-1077 dose were compared to 150 mg L-DOPA, each in combination with 37...
June 29, 2018: British Journal of Clinical Pharmacology
Rodrigo Metzker Pereira Ribeiro, Fernanda de Lima Moreira, Elaine Christine Dantas Moisés, Ricardo Carvalho Cavalli, Silvana Maria Quintana, Vera Lucia Lanchote, Geraldo Duarte
AIM: The present study evaluated the placental transfer and amniotic fluid distribution of bupivacaine enantiomers in health pregnant women and in HIV-infected pregnant women receiving epidural anaesthesia for caesarean section. METHODS: Twelve HIV-infected pregnant women (HIV group) were treated long-term (at least 8 weeks) with lopinavir/ritonavir (400/100 mg bid), and twelve healthy pregnant women (Control group) who submitted to epidural anaesthesia with racemic bupivacaine (75 mg) during caesarean section were investigated...
June 29, 2018: British Journal of Clinical Pharmacology
Yuji Kumagai, Hideki Amano, Yoshinobu Sasaki, Chie Nakagawa, Mika Maeda, Ichiro Oikawa, Hidetoshi Furuie
AIMS: Elobixibat is a minimally absorbed ileal bile acid transporter inhibitor. This study aimed to investigate the safety, tolerability, efficacy, pharmacokinetics (PK) and pharmacodynamics of elobixibat in Japanese patients with chronic constipation (CC). METHODS: This study consisted of single-dose and multiple-dose tests with a dose-escalating design. Sixty patients including female and male were randomised into five dose levels of elobixibat (2.5, 5, 10, 15 or 20 mg, n = 10 per level) and corresponding placebo (n = 2 per group)...
June 29, 2018: British Journal of Clinical Pharmacology
Nikesh Parekh, Jennifer M Stevenson, Rebekah Schiff, J Graham Davies, Stephen Bremner, Tischa Van der Cammen, Jatinder Harchowal, Chakravarthi Rajkumar, Khalid Ali
AIMS: Medication-related harm (MRH) is common in older adults following hospital discharge. In resource-limited health systems, interventions to reduce this risk can be targeted at high-risk patients. This study aims to determine whether (1) doctors can predict which older patients will experience MRH requiring healthcare following hospital discharge, (2) clinical experience and confidence in prediction influence the accuracy of the prediction. METHODS: A multicentre observational prospective study involving five teaching hospitals in England between September 2013 and November 2015...
June 29, 2018: British Journal of Clinical Pharmacology
Spyridon Siafis, Georgios Papazisis
AIM: Recent data suggest that antidepressants are associated with incident diabetes but the possible pharmacological mechanism is still questioned. The aim of the present study was to evaluate antidepressant's risk for reporting diabetes using disproportionality analysis of the FDA adverse events spontaneous reporting system (FAERS) database and to investigate possible receptor/transporter mechanisms involved. METHODS: Data from 2004 to 2017 were analyzed using OpenVigil2 and adjusted reporting odds ratio (aROR) for reporting diabetes was calculated for 22 antidepressants...
June 28, 2018: British Journal of Clinical Pharmacology
Laura M Dryburgh, Nanthi S Bolan, Christopher P L Grof, Peter Galettis, Jennifer Schneider, Catherine J Lucas, Jennifer H Martin
BACKGROUND: There has been a resurgence in interest and use of the Cannabis plant for medical purposes. However, an in-depth understanding of plant contaminants and toxins effects on; stability of plant compounds and human bioavailability is needed. AIMS: This systematic review aims to assess current understanding of the contaminants of Cannabis and their effect on human health, leading to the identification of knowledge gaps for future investigation. METHODS: A systematic search of seven indexed biological and biomedical databases and the Cochrane library was undertaken from inception up to December 2017...
June 28, 2018: British Journal of Clinical Pharmacology
Elin M Svensson, Jeannine du Bois, Rene Kitshoff, Veronique R de Jager, Lubbe Wiesner, Jennifer Norman, Sharon Nachman, Betsy Smith, Andreas Diacon, Anneke C Hesseling, Anthony J Garcia-Prats
OBJECTIVES: Bedaquiline is an important novel drug for treatment of multidrug-resistant tuberculosis, but no paediatric formulation is yet available. This work aimed to explore the possibility of using the existing tablet formulation in children by evaluating the relative bioavailability, short-term safety, acceptability and palatability of suspended bedaquiline tablets compared to whole tablets. METHODS: A randomized, open-label, two-period cross-over study was conducted in 24 healthy adult volunteers...
June 27, 2018: British Journal of Clinical Pharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"