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British Journal of Clinical Pharmacology

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https://www.readbyqxmd.com/read/29334406/dasatinib-induced-pulmonary-arterial-hypertension
#1
REVIEW
Nurgül Özgür Yurttaş, Ahmet Emre Eşkazan
Drug-induced (Group 1) pulmonary hypertension (PH) is an important subgroup of PH involving dasatinib as a likely related agent, which is a second-generation tyrosine kinase inhibitor (TKI), that is used in the treatment of chronic myeloid leukemia (CML). The mechanism of dasatinib-induced pulmonary arterial hypertension (PAH) is unclear. However, the occurence of PAH at a late onset in CML patients suggests a chronic pathological mechanism with an insidious onset rather than an acute inflammatory or cardiac etiology...
January 15, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29333656/first-case-of-stevens-johnson-syndrome-after-rabies-vaccination
#2
Li Ma, Xusheng Du, Yu Dong, Lirong Peng, Xiaonian Han, Jianhua Lyu, Hehe Bai
We describe the first case of Stevens-Johnson syndrome (SJS) occurring 8 days after the first dose of a 3-dose rabies vaccination series. She had no history of vaccine-related rash or other adverse drug reactions, nor had she received any other drug therapy. The temporal relationship between the development of SJS and the vaccination suggests that the rabies vaccination probably was the causal agent. This case serves as a warning of a distinct cutaneous reaction of rabies vaccination.
January 15, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29333622/metabolic-acidosis-and-anaemia-associated-with-dorzolamide-in-a-patient-with-impaired-renal-function
#3
Iva Hoffmanová, Daniel Sánchez
Topical carbonic anhydrase inhibitors (CAI), used for treatment of glaucoma, are generally regarded as safe and unconnected with systemic side effects. We report an unusual case of fatigue, metabolic acidosis, and normocytic anaemia associated with ocular administration of the CAI, dorzolamide, in a patient with impaired renal function. In chronic kidney disease, where CAI elimination may be decreased, and patients prone to develop metabolic acidosis, systemic absorption of ocular administered CAI could lead to rare, but potentially serious adverse reaction, that are a consequence of inhibition of extraocular carbonic anhydrase isoenzymes...
January 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29328514/a-systematic-review-of-population-pharmacokinetics-of-valproic-acid
#4
Janthima Methaneethorn
AIMS: Population pharmacokinetics is an essential tool that helps guiding individualized dosing regimens. The aims of this systematic review are to provide knowledge concerning population pharmacokinetics of valproic acid (VPA) and to identify factors influencing VPA pharmacokinetic variability. METHODS: Pubmed and Embase databases were systematically searched from inception to June, 2017. Relevant articles from reference lists were also included. All population pharmacokinetic studies of VPA conducted in human and employed nonlinear mixed effect modeling approach were included in this review...
January 12, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29319910/reversal-of-mecamylamine-induced-effects-in-healthy-subjects-by-nicotine-receptor-agonists-cognitive-and-electro-physiological-responses
#5
Ricardo Alvarez-Jimenez, Ellen P Hart, Samantha Prins, Marieke de Kam, Joop M A van Gerven, Adam F Cohen, Geert Jan Groeneveld
AIM: Establishing a pharmacologic challenge model could yield an important tool to understand the complex role of the nicotinic cholinergic system in cognition and to develop novel compounds acting on the nicotinic acetylcholine receptor. METHODS: This randomized, double-blind, double-dummy, placebo-controlled, four way cross-over study examined the effects of the nicotinic antagonist mecamylamine on a battery of cognitive and neurophysiologic test with co-administration of a placebo, nicotine or galantamine in order to reverse the cognitive impairment caused by mecamylamine...
January 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29319891/teicoplanin-anaphylaxis-associated-with-surgical-prophylaxis
#6
Tariq Azamgarhi, Ashik Shah, Simon Warren
BACKGROUND: The rate of true anaphylaxis to teicoplanin is currently unknown. METHODS: A case-series including all suspected anaphylactic reactions attributed to teicoplanin anaphylaxis within a single institution over a 29-month period were categorised according to the probability of true IgE mediated anaphylaxis using previously published criteria. The number of patients who receive Teicoplanin was determined and used to calculate the rate of IgE mediated anaphylaxis...
January 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29318653/pharmacokinetic-pharmacodynamic-modelling-of-neutrophil-response-to-g-csf-in-healthy-subjects-and-patients-with-chemotherapy-induced-neutropenia
#7
Murad Melhem, Isabelle Delor, Juan Jose Pérez-Ruixo, John Harrold, Andrew Chow, Liviawati Wu, Philippe Jacqmin
AIM: The objective of this study was to use pharmacokinetic-pharmacodynamic modelling to characterize the effects of chemotherapy on the granulopoietic system and to predict the absolute neutrophil counts (ANCs) for patients with chemotherapy-induced neutropenia (CIN) treated with filgrastim and pegfilgrastim. METHODS: Data were extracted from 10 phase 1-3 studies conducted in 110 healthy adults and 618 adult and 52 paediatric patients on chemotherapy following administration of filgrastim or pegfilgrastim...
January 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29318651/effect-of-the-angiotensin-receptor-neprilysin-inhibitor-sacubitril-valsartan-on-pharmacokinetics-and-pharmacodynamics-of-a-single-dose-of-furosemide
#8
Surya Ayalasomayajula, Uwe Schuehly, Parasar Pal, Fabian Chen, Wei Zhou, Gangadhar Sunkara, Thomas H Langenickel
AIMS: Sacubitril/valsartan is indicated for the treatment of heart failure and reduced ejection fraction (HFrEF). Furosemide, a loop diuretic commonly used for the treatment of HFrEF, may be co-administrated with sacubitril/valsartan in clinical practice. The effect of sacubitril/valsartan on pharmacokinetics and pharmacodynamics of furosemide was evaluated in this open label, two- period, single-sequence study in healthy subjects (N=28). METHODS: All subjects received 40 mg oral single dose furosemide during period 1 followed by washout of 2 days...
January 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29315699/topical-administration-of-regorafenib-eye-drops-phase-i-dose-escalation-study-in-healthy-volunteers
#9
Torsten Zimmermann, Joachim Höchel, Michael Becka, Michael K Boettger, Beate Rohde, Barbara Schug, Kathleen S Kunert, Frank Donath
AIM: Regorafenib is a multi-kinase inhibitor under investigation for use in neovascular age-related macular degeneration. In this Phase I study, regorafenib eye drops were administered to healthy volunteers to provide information on safety, tolerability and systemic exposure. METHODS: This was a single-centre, randomized, double-masked, parallel-group, dose-escalation, placebo-controlled study. Subjects received regorafenib eye drops (30 mg ml-1 , 25 μL) as a 0...
January 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29315721/do-final-year-medical-students-have-sufficient-prescribing-competencies-a-systematic-literature-review
#10
David J Brinkman, Jelle Tichelaar, Sanne Graaf, René H J Otten, Milan C Richir, Michiel A van Agtmael
AIMS: Prescribing errors are an important cause of patient safety incidents and are frequently caused by junior doctors. This might be because the prescribing competence of final-year medical students is poor as a result of inadequate clinical pharmacology and therapeutic (CPT) education. We reviewed the literature to investigate which prescribing competencies medical students should have acquired in order to prescribe safely and effectively, and whether these have been attained by the time they graduate...
January 8, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29315758/fatal-prescription-charts
#11
EDITORIAL
John B Warren
No abstract text is available yet for this article.
January 6, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29315725/response-to-aprepitant-and-fosaprepitant-decrease-the-effectiveness-of-hormonal-contraceptives
#12
LETTER
Priya Patel, J Steven Leeder, Micheline Piquette-Miller, L Lee Dupuis
No abstract text is available yet for this article.
January 6, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29315713/comment-on-use-of-antibiotics-during-pregnancy-and-the-risk-of-major-congenital-malformations-a-population-based-cohort-study-by-muanda-et-al
#13
LETTER
Selin Acar, Hilal Erol-Coskun, Yusuf Cem Kaplan
No abstract text is available yet for this article.
January 6, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29314183/fixed-dosing-of-intravenous-tocilizumab-in-rheumatoid-arthritis-results-from-a-population-pharmacokinetic-analysis
#14
Carla Bastida, Virginia Ruiz-Esquide, Mariona Pascal, Aurelia H M de Vries Schultink, Jordi Yagüe, Raimon Sanmartí, Alwin D R Huitema, Dolors Soy
AIM: Intravenous tocilizumab is currently dosed on body weight although a weak correlation between body weight and clearance has been described. The aim of the study was to assess the current dosing strategy and provide a scientific rational for dosing using a modeling and simulation approach. METHODS: Serum concentrations and covariates were obtained from intravenous tocilizumab treated subjects at a dose of 4, 6 or 8 mg every 28 days. A population pharmacokinetic analysis was performed using nonlinear mixed effects modeling...
January 4, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29293280/gender-differences-in-clinical-registration-trials-is-there-a-real-problem
#15
G Labots, A Jones, S J de Visser, R Rissmann, J Burggraaf
AIMS: Several studies reported under-representation of women in clinical trials, thereby challenging the external validity of benefit/risk assessments of launched drugs. Our aim was to determine the extent to which women have been included in clinical trials used for drug registration and to analyse the fraction of women participating in phase 1, 2 and 3. METHODS: We conducted a cross sectional, structured research of publicly available registration dossiers of FDA approved drugs that are frequently prescribed...
January 2, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29292523/association-between-antidepressant-medication-use-and-epithelial-ovarian-cancer-risk-a-systematic-review-and-meta-analysis-of-observational-studies
#16
REVIEW
Yun-Long Huo, Jia-Ming Qiao, Song Gao
AIM: To clarify the inconsistent findings in the association between antidepressant use and the risk of epithelial ovarian cancer (EOC). METHODS: Meta-analysis of observational studies retrieved from the PubMed, EMBASE, and Web of Science databases prior to August 15, 2017. Two researches independently screened studies and extracted study characteristics and risk estimates. The odds ratios (OR) and 95% confidence intervals (CI) of EOC risk were summarized using an inverse variance weighted random-effects model...
January 2, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29274100/population-exposure-safety-analysis-of-cediranib-for-phase-i-and-ii-studies-in-patients-with-cancer
#17
N Al-Huniti, K Petersson, W Tang, E Masson, J Li
No abstract text is available yet for this article.
December 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29272556/characterization-of-adherence-and-persistence-profile-in-a-real-life-population-of-patients-treated-with-adalimumab
#18
Omer Gendelman, Dahlia Weitzman, Vered Rosenberg, Varda Shalev, Gabriel Chodick, Howard Amital
BACKGROUND: Published data on long term adherence and persistence with Adalimumab (Humira®) in clinical practice are scarce and often limited to selected patient populations. This study assessed adherence with adalimumab across different indications and identified correlates and outcomes of poor adherence. METHODS: We analyzed data originating from the electronic database of Maccabi Healthcare Services (MHS) that includes 2.1 million enrollees. We randomly selected patients with at least one dispense of adalimumab since it was included in the local health basket in Israel in 2008 until the end of 2013...
December 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29266387/safety-and-efficacy-of-parenteral-iron-in-children-with-inflammatory-bowel-disease
#19
Michael Papadopoulos, Deepa Patel, Roxanna Korologou-Linden, Eunice Goto, Krishna Soondrum, John M E Fell, Jenny Epstein
OBJECTIVES: Iron deficiency anaemia (IDA) frequently complicates inflammatory bowel disease (IBD) in children and adults. Oral iron may exacerbate gastrointestinal symptoms and absorption may be insufficient in intestinal inflammation. Even where oral iron is successful, repletion of iron stores can be unacceptably slow. Intravenous (IV) iron compounds were in the past associated with serious adverse reactions and historically were considered a last resort in children. New generation preparations have a safer profile in adults although reluctance to use them in children may persist, where safety data is lacking...
December 20, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29266364/aprepitant-and-fosaprepitant-decrease-the-effectiveness-of-hormonal-contraceptives
#20
LETTER
Neil Bailard, Elizabeth Rebello
No abstract text is available yet for this article.
December 19, 2017: British Journal of Clinical Pharmacology
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