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British Journal of Clinical Pharmacology

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https://www.readbyqxmd.com/read/28736944/short-term-acipimox-treatment-is-associated-with-decreased-cardiac-parasympathetic-modulation
#1
Esben Thyssen Vestergaard, Simon Lebech Cichosz, Niels Møller, Jens Otto Lunde Jørgensen, Jesper Fleischer
AIM: The nicotinic acid analogue acipimox is an anti-lipolytic agent, which acutely inhibits lipolysis, and suppresses systemic levels of free fatty acids (FFA) and improves insulin sensitivity in obese patients. These effects of acipimox are transient due to a counter-regulatory increase in growth hormone (GH) levels that reverse the anti-lipolytic effect of acipimox. Hypopituitary patients constitute a viable model to study the GH-independent effects of acipimox and the impact of isolated changes in FFA concentrations and insulin sensitivity on parasympathetic nervous activity...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28735510/fxa-inhibition-by-rivaroxaban-modifies-mechanisms-associated-with-the-pathogenesis-of-human-abdominal-aortic-aneurysms
#2
G Moñux, J J Zamorano-León, P Marqués, B Sopeña, J M García-García, G Laich de Koller, B Calvo-Rico, M A García-Fernandez, J Serrano, A López-Farré
AIM: To evaluate if Rivaroxaban, an oral factor Xa (FXa) inhibitor, could in vitro modify the expression of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS: AAA sites with intraluminal mural thrombus were obtained from six patients undergoing elective AAA repair. In addition, control abdominal aortic samples were obtained from six organ donors. AAA sites were incubated in the presence and absence of 50 nmol/L Rivaroxaban...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28735507/response-to-r-warfarin-anticoagulant-effect
#3
LETTER
Ling Xue, Nick Holford, Li-Yan Miao
No abstract text is available yet for this article.
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28734011/maternal-ssri-discontinuation-use-psychiatric-disorder-and-the-risk-of-autism-in-children-a-meta-analysis-of-cohort-studies
#4
Yusuf Cem Kaplan, Elif Keskin-Arslan, Selin Acar, Kaan Sozmen
We undertook an exclusive meta-analysis of cohort studies investigating the possible link between prenatal SSRI exposure and autism spectrum disorders (ASD) in children to further investigate our previous suggestion of confounding by indication. The point estimates regarding the following cohorts were extracted and pooled: (1) Pregnant women who discontinued SSRI until 3 months before pregnancy. (2) Pregnant women who were exposed to SSRI during pregnancy. (3) Pregnant women with maternal psychiatric disorder but no exposure to SSRI during pregnancy...
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28734007/real-world-complexity-of-atrial-fibrillation-treatment-with-oral-anticoagulants-design-and-interpretation-of-pharmacoepidemiological-studies
#5
LETTER
Andreas D Meid, Sarah Mächler, Walter E Haefeli, Gerd Mikus
No abstract text is available yet for this article.
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28733983/population-pharmacokinetics-and-exposure-response-of-trastuzumab-emtansine-in-advanced-breast-cancer-previously-treated-with-%C3%A2-2-her2-targeted-regimens
#6
Shang-Chiung Chen, Angelica Quartino, Daniel Polhamus, Matthew Riggs, Jonathan French, Xin Wang, Shweta Vadhavkar, Melanie Smitt, Silke Hoersch, Alexander Strasak, Jin Yan Jin, Sandhya Girish, Chunze Li
AIMS: We conducted population pharmacokinetic (PopPK) and exposure-response analyses for trastuzumab emtansine (T-DM1) to assess the need for T-DM1 dose optimization in patients with low exposure by using TH3RESA study data (NCT01419197). The randomized phase III TH3RESA study investigated T-DM1 vs. treatment of physician's choice (TPC) in patients with heavily pretreated HER2-positive advanced breast cancer. METHODS: We compared a historical T-DM1 PopPK model with T-DM1 pharmacokinetics in TH3RESA and performed exposure-response analyses using model-predicted cycle 1 Cmax , cycle 1 Cmin , and AUCss ...
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28722184/appropriateness-of-antiplatelet-therapy-for-primary-and-secondary-cardio-and-cerebrovascular-prevention-in-acutely-hospitalized-older-people
#7
I Ardoino, R Rossio, D Di Blanca, A Nobili, L Pasina, P M Mannucci, F Peyvandi, C Franchi
BACKGROUND: Antiplatelet therapy is recommended for the secondary prevention of cardio- and cerebrovascular disease, but for primary prevention it is advised only in patients at very high risk. With this background, this study aims to assess the appropriateness of antiplatelet therapy in acutely hospitalized older people according to their risk profile. METHODS: Data were obtained from the REPOSI register held in Italian and Spanish internal medicine and geriatric wards in 2012 and 2014...
July 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28722171/use-of-antibiotics-during-pregnancy-and-the-risk-of-major-congenital-malformations-a-population-based-cohort-study
#8
Flory T Muanda, Odile Sheehy, Anick Bérard
INTRODUCTION: Few studies have investigated the link between individual antibiotics and major congenital malformations (MCMs) including specific malformations owing to small sample size. We aimed to quantify the association between exposure to gestational antibiotic and the risk of MCMs. METHODS: Using the Quebec pregnancy cohort (1998 -2008), we included a total of 139,938 liveborn singleton alive whose mothers were covered by the «Régie de l'assurance maladie du Québec" drug plan for at least 12 months before and during pregnancy...
July 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28722153/pharmacokinetics-and-safety-of-the-anti-human-cytomegalovirus-drug-letermovir-in-subjects-with-hepatic-impairment
#9
D Kropeit, D McCormick, K Erb-Zohar, V S Moiseev, Z D Kobalava, H P Stobernack, H Zimmermann, H Rübsamen-Schaeff
AIM: Human cytomegalovirus constitutes a prevalent and serious threat to immunocompromised individuals and requires new treatments. Letermovir is a novel viral-terminase inhibitor that has demonstrated prophylactic/preemptive activity against human cytomegalovirus in Phase 2 and 3 transplant trials. As unchanged letermovir is primarily excreted via the liver by bile, this trial aimed to assess the effect of hepatic impairment on letermovir pharmacokinetics. METHODS: Phase 1, open-label, parallel-group pharmacokinetic and safety comparison of multiple once-daily oral letermovir in female subjects with hepatic impairment and healthy matched controls...
July 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28715853/effect-of-gemfibrozil-or-rifampicin-on-the-pharmacokinetics-of-selexipag-and-its-active-metabolite-in-healthy-subjects
#10
Shirin Bruderer, Marc Petersen-Sylla, Margaux Boehler, Tatiana Remeňová, Atef Halabi, Jasper Dingemanse
AIMS: Based on in vitro data CYP2C8 is involved in the metabolism of selexipag and its active metabolite, ACT-333679. The present study evaluated the possible pharmacokinetic interactions of selexipag with gemfibrozil, a strong CYP2C8 inhibitor and rifampicin, an inducer of CYP2C8. METHODS: The study consisted of two independent parts, each conducted according to an open-label, randomized crossover design. The pharmacokinetics and safety of selexipag and ACT-333679 were studied following single-dose administration either alone or in the presence of multiple-dose gemfibrozil (Part I) or rifampicin (Part II) in healthy male subjects...
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28715608/ticagrelor-mitigates-ischemia-reperfusion-induced-vascular-endothelial-dysfunction-in-healthy-young-males-a-randomised-single-blinded-study
#11
Stefan Weisshaar, Brigitte Litschauer, Matthias Eipeldauer, Eva Luise Hobl, Michael Wolzt
AIM: Animal data suggest that ticagrelor but not clopidogrel protects against tissue injury. It is unclear if this effect of ticagrelor is also detectable in humans. We studied the effect of ticagrelor and clopidogrel at standard clinical doses on endothelial dysfunction in an experimental model of forearm vascular ischemia-reperfusion (IR) injury. METHODS: In a randomised, single-blinded trial 24 subjects underwent forearm blood flow (FBF) measurements in response to the endothelium-dependent vasodilator acetylcholine (ACh) and to glyceryltrinitrate (GTN; endothelium-independent) before and after a 20 min forearm ischemia...
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28714109/opioids-out-of-control
#12
EDITORIAL
Christopher N Floyd, John B Warren
No abstract text is available yet for this article.
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28707406/quantitative-efficacy-of-topical-administration-of-tranexamic-acid-on-postoperative-bleeding-in-total-knee-arthroplasty
#13
Ruijuan Xu, Dongquan Shi, Weihong Ge, Qing Jiang
AIMS: Topical tranexamic acid (TXA) was used in patients undergoing total knee arthroplasty to reduce perioperative blood loss. However, the optimal dosing regimen remains undetermined. The aim of the present study was to quantitatively evaluate the effect of topical TXA on the reduction of postoperative drainage, and identify the dosing regimen factors affecting the efficacy of topical TXA. METHODS: Model based meta-analysis (MBMA) was used to evaluate the efficacy of topical TXA and the dosing regimen factors influencing clinical efficacy...
July 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28707329/drugs-and-obstructive-sleep-apnoea
#14
LETTER
Bruno Revol, Ingrid Jullian-Desayes, Jean-Louis Pepin, Marie Joyeux-Faure
No abstract text is available yet for this article.
July 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28701029/high-risk-prescribing-in-an-irish-primary-care-population-trends-and-variation
#15
Catherine J Byrne, Caitriona Cahir, Carmel Curran, Kathleen Bennett
AIMS: To examine the prevalence of high-risk prescribing (HRP) in community-dwelling adults in Ireland from 2011-2015 using consensus-validated indicators, factors associated with HRP, and variation in HRP between general practitioners (GPs) and dispensing of high-risk prescriptions between pharmacies. METHODS: A repeated cross-sectional national pharmacy claims database study. Prescribing indicators were based on those developed in formal consensus studies and applicable to pharmacy claims data...
July 12, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28695570/population-pharmacokinetics-and-electrocardiographic-effects-of-dihydroartemisinin-piperaquine-in-healthy-volunteers
#16
Palang Chotsiri, Thanaporn Wattanakul, Richard Hoglund, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Daniel Blessborn, Podjanee Jittamala, Nicholas J White, Nicholas P J Day, Joel Tarning
AIMS: The aims of the presented study were to evaluate the pharmacokinetic properties of dihydroartemisinin and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS: Population pharmacokinetic properties of dihydroartemisinin and piperaquine were assessed in 16 in healthy Thai adults using an open-label randomized crossover study. Drug concentration-time data and electrocardiographic measurements were evaluated with nonlinear mixed-effects modelling...
July 11, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28689375/psychotropic-polypharmacy-in-australia-2006-to-2015-a-descriptive-cohort-study
#17
Jonathan Brett, Benjamin Daniels, Emily A Karanges, Nicholas A Buckley, Carl Schneider, Atheer Nassir, Andrew J McLachlan, Sallie-Anne Pearson
AIMS: To describe psychotropic polypharmacy in Australia between 2006 and 2015. METHODS: We used pharmaceutical claims from a national 10% sample of people with complete dispensing histories to estimate the annual prevalence of the combined use (overlap of > 60 days exposure) of ≥2 psychotropics overall and within the same class or subclass (class and subclass polypharmacy). We also estimated the proportion of polypharmacy episodes involving one, two, three and four or more unique prescribers...
July 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28688130/the-pharmaceutical-industry-needs-more-clinical-pharmacologists
#18
Richard Peck
No abstract text is available yet for this article.
July 8, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28688108/a-physiologically-based-pharmacokinetic-modeling-approach-to-predict-buprenorphine-pharmacokinetics-following-intravenous-sublingual-administration
#19
Hari V Kalluri, Hongfei Zhang, Steve N Caritis, Raman Venkataramanan
INTRODUCTION: Opioid dependence is associated with high morbidity and mortality. Buprenorphine(BUP) is approved by the FDA to treat opioid dependence. There is a lack of clear consensus on appropriate dosing of BUP due to inter-patient physiological differences in absorption/disposition, subjective response assessment and other patient comorbidities. The objective of this study is to build and validate robust physiologically-based-pharmacokinetic(PBPK) models for intravenous(IV) and Sublingual(SL) BUP as a first-step to optimize BUP pharmacotherapy...
July 8, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28686294/nfat-regulated-cytokine-gene-expression-during-tacrolimus-therapy-early-after-renal-transplantation
#20
Sara Bremer, Nils T Vethe, Morten Skauby, Margrete Kasbo, Elisabet D Johansson, Karsten Midtvedt, Stein Bergan
AIMS: Despite pharmacokinetic monitoring of calcineurin inhibitors, the long-term outcome after transplantation (Tx) is still hampered by the side effects of these drugs. The aim of this study was to characterize the nuclear factor of activated T cells (NFAT)-regulated gene expression as a potential pharmacodynamic biomarker for further individualization of tacrolimus (Tac) therapy. METHODS: In 29 renal allograft recipients samples were drawn once pre-Tx, and before and 1...
July 7, 2017: British Journal of Clinical Pharmacology
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