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Memórias do Instituto Oswaldo Cruz

Luis Ernesto Contreras-Rodríguez, Catherin Yizet Marin-Mogollon, Lina Marcela Sánchez-Mejía, María Helena Ramírez-Hernández
The biochemical pathways involved in nicotinamide adenine dinucleotide (NAD) biosynthesis converge at the enzymatic step catalysed by nicotinamide mononucleotide adenylyltransferase (NMNAT, EC: The majority of NMNATs are assembled into homo-oligomeric states that comprise 2-6 subunits. Recently, the NMNAT of Plasmodium falciparum (PfNMNAT) has been identified as a pharmacological target. The enzymatic characterisation, cellular location, and tertiary structure of the PfNMNAT protein have been reported...
July 10, 2018: Memórias do Instituto Oswaldo Cruz
Juliana Nunes Ramos, Izabel Dos Santos Rodrigues, Paulo Victor Pereira Baio, João Flávio Carneiro Veras, Rommel Thiago Jucá Ramos, Luis Gc Pacheco, Vasco Ariston Azevedo, Raphael Hirata Júnior, Michel Abanto Marín, Ana Luiza de Mattos-Guaraldi, Verônica Viana Vieira
Multidrug-resistant (MDR) Corynebacterium striatum has been cited with increased frequency as pathogen of nosocomial infections. In this study, we report the draft genome of a C. striatum isolated from a patient with bloodstream infection in a hospital of Rio de Janeiro, Brazil. The isolate presented susceptibility only to tetracycline, vancomycin and linezolid. The detection of various antibiotic resistance genes is fully consistent with previously observed multidrug-resistant pattern in Corynebacterium spp...
July 10, 2018: Memórias do Instituto Oswaldo Cruz
Edson Machado, Sidra Ezidio Gonçalves Vasconcellos, Camillo Cerdeira, Lia Lima Gomes, Ricardo Junqueira, Luciana Distasio de Carvalho, Jesus Pais Ramos, Paulo Redner, Carlos Eduardo Dias Campos, Paulo Cesar de Souza Caldas, Ana Paula Chaves Sobral Gomes, Telma Goldenberg, Fatima Fandinho Montes, Fernanda Carvalho de Queiroz Mello, Vinicius de Oliveira Mussi, Elena Lasunskaia, Dick van Soolingen, Antonio Basílio de Miranda, Leen Rigouts, Bouke C de Jong, Conor J Meehan, Marcos Catanho, Philip N Suffys
Mycobacterium kansasii is an opportunistic pathogen and one of the most commonly encountered species in individuals with lung disease. We here report the complete genome sequence of 12 clinical isolates of M. kansasii from patients with pulmonary disease in Brazil.
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Lysianne Pinto, Luiz Fernando Zmetek Granja, Mariana Amorim de Almeida, Daniela Sales Alviano, Maria Helena da Silva, Regina Ejzemberg, Sonia Rozental, Celuta Sales Alviano
BACKGROUND: Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America. OBJECTIVE: The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fungal cell ghosts obtained by Novozym 234 treatment on their ability to activate the human complement system...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Marcos César Lima de Mendonça, Maria Angelica Mares-Guia, Cintia Damasceno Dos Santos Rodrigues, Carolina Cardoso Dos Santos, Flavia Lowen Levy Chalhoub, Eliane Saraiva Machado Araújo, Alexandre Otávio Chieppe, Rita Maria Ribeiro Nogueira, Ana Maria Bispo de Filippis
The dengue virus (DENV), of the genus Flavivirus (Flaviviridae), has four antigenically distinct serotypes, of which DENV-3 is classified into five genotypes. Here, we describe the detection of DENV-3 genotype I in sera of a Brazilian patient travelling from Singapore to Rio de Janeiro, Brazil, by using multiplex real-time RT-PCR, DNA sequencing of the whole envelope protein gene, and phylogenetic analysis. The virus shares ancestry with those identified in Bali, Indonesia, in 2015. It is possible that arboviruses such as Chikungunya ECSA genotype, DENV-4 genotype I, and Zika were introduced in Brazil from other continents during the multiple international events hosted by the country over the last four years, including World Youth Day, the Soccer World Cup, and the Summer Olympics...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Paulo Sousa Prado, José Teófilo Duarte Almeida Júnior, Lanna Takada de Abreu, Cristina Gabriel Silva, Larissa da Costa Souza, Marizoneide Cavalcante Gomes, Lucinda Malheiros Teixeira Mendes, Eliane Maria Dos Santos, Gustavo Adolfo Sierra Romero
BACKGROUND: The diagnosis of dengue is complex. Until recently, only specialised laboratories were able to confirm dengue infection. However, this has changed with the newly available immunochromatographic rapid tests. Early diagnosis is of great interest, and point-of-care rapid tests have been increasingly used in Brazil. Most of those tests have not undergone validation in the Brazilian population. In this context, we decided to evaluate a rapid test introduced in the Federal District (FD)...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Dario Brock Ramalho, Rosiana Estéfane da Silva, Maria Camilo Ribeiro de Senna, Hugo Silva Assis Moreira, Mariana Junqueira Pedras, Daniel Moreira de Avelar, Lara Saraiva, Ana Rabello, Gláucia Cota
BACKGROUND: Cutaneous leishmaniasis (CL) is a world-wide health problem which currently lacks effective, affordable and easy to use therapy. Recently, the meglumine antimoniate (MA) intralesional infiltration was included among the acceptable therapies for New World leishmaniasis. While this approach is attractive, there is currently little evidence to support its use in Americas. OBJECTIVES: The aim of this study was to provide information about effectiveness and safety of a standardised MA intralesional infiltration technique for the treatment of CL...
June 21, 2018: Memórias do Instituto Oswaldo Cruz
Bianca Cristina Leires Marques, Mariza Gonçalves Morgado, Monick Lindenmeyer Guimarães
In Brazil, detection of the HIV-1 sub-subtype F1 has decreased with a simultaneous increase in detection of the recombinant FB and FC forms. In previous HIV-1 env molecular epidemiology studies in Rio de Janeiro, 11.4% of the detected sequences were of the F1 sub-subtype. With the goal of re-estimating the prevalence of the HIV-1 F1 sub-subtype, we performed extended analyses of these samples by examining five genomic regions, resulting in 3.3% being confirmed as F1. Moreover, genomic analysis of 11 of the 21 samples identified as F1 confirmed that nine were F1 and two were BF1...
June 11, 2018: Memórias do Instituto Oswaldo Cruz
Marcio Roberto Silva, Adalgiza da Silva Rocha, Flábio Ribeiro Araújo, Antônio Augusto Fonseca-Júnior, Andrea Padilha de Alencar, Philip Noel Suffys, Ronaldo Rodrigues da Costa, Maria Aparecida Scatamburlo Moreira, Mark Drew Crosland Guimarães
BACKGROUND: The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study. OBJECTIVE: The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes...
June 11, 2018: Memórias do Instituto Oswaldo Cruz
João Pedro Rueda Furlan, André Pitondo-Silva, Eliana Guedes Stehling
This study reports the presence of the blaNDM-1 gene in an isolate of Stenotrophomonas maltophilia obtained from a Brazilian soil, inside an IncA/C plasmid with ~ 45 Kb. To the best of our knowledge, this is the second report in the world and the first in Brazil of NDM-producing bacterium isolated from soil.
May 14, 2018: Memórias do Instituto Oswaldo Cruz
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
Sudhansu Sekhar Sahu, Smrutidhara Dash, Thankachy Sonia, Subramaniam Muthukumaravel, Thirumal Sankari, Kasinathan Gunasekaran, Purushothaman Jambulingam
BACKGROUND: A severe outbreak of Japanese encephalitis (JE) and acute encephalitis syndrome (AES) with high case fatality was reported from Malkangiri district of Odisha state, India during September to November 2016 affecting 336 children with 103 deaths. OBJECTIVES: The purpose of this study was to investigate the outbreak in the light of entomological determinants. METHODS: Entomological investigation was carried out in 48 villages from four mostly affected Community Health Centres (CHCs) of Malkangiri district...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
Lucia Elena Alvarado-Arnez, Angelica Martins Batista, Silvia Marinho Alves, Gloria Melo, Virgínia Maria Barros de Lorena, Cynthia C Cardoso, Isabela Resende Pereira, Cristina Carrazzone, Antonio G Pacheco, Wilson Oliveira, Milton Ozório Moraes, Joseli Lannes-Vieira
BACKGROUND: The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
Helen Aline Melo, Diogo Francisco Rossoni, Ueslei Teodoro
BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in the state of Paraná, Brazil. OBJECTIVE: This study aimed at analysing the influence of the remaining native vegetation on the prevalence of CL in Paraná. METHODS: Global testing was used for spatial autocorrelation along with simultaneous autoregressive model (SAR). The regression was based on the CL coefficient (cases/100,000 inhabitants) as a function of the percentage of natural vegetation cover, altitude, total number of cases, and spatial density (SD) per km2; the location data of the Paraná state municipalities and the detection coefficient (DC) (cases/100,000 inhabitants) of autochthonous cases of CL were obtained from the SINAN in 2012 and 2016...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
Caio César de Melo Freire, Giuseppe Palmisano, Carla T Braconi, Fernanda R Cugola, Fabiele B Russo, Patricia Cb Beltrão-Braga, Atila Iamarino, Daniel Ferreira de Lima Neto, Amadou Alpha Sall, Livia Rosa-Fernandes, Martin R Larsen, Paolo Marinho de Andrade Zanotto
BACKGROUND: Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome...
May 10, 2018: Memórias do Instituto Oswaldo Cruz
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Memórias do Instituto Oswaldo Cruz
André Filipe Pastor, Abraham Rocha, Klécia de Melo Cassemiro, Marli Tenório, Paula Melo, Maria Rosângela Grilis, Maressa Rhuama, Antonio Mauro Rezende, Osvaldo Pompilio de Melo Neto, Ernesto Marques, Rafael Dhalia
BACKGROUND: Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity) and limited diagnostic kits. OBJECTIVES: The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT) as part of an enzyme-linked immunosorbent assay (ELISA) based antibody capture tests for LF...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
Rafaella Albuquerque E Silva, Andrey José de Andrade, Bruno Beust Quint, Gabriel Elias Salmen Raffoul, Guilherme Loureiro Werneck, Elizabeth Ferreira Rangel, Gustavo Adolfo Sierra Romero
BACKGROUND: There is little information on the effect of using deltamethrin-impregnated dog collars for the control of canine visceral leishmaniasis. OBJECTIVES: The objective of this study was to evaluate the effectiveness of the use of 4% deltamethrin-impregnated collars (Scalibor®) in controlling visceral leishmaniasis in Lutzomyia longipalpis by comparing populations in intervention and non-intervention areas. METHODS: Phlebotomine flies were captured over 30 months in four neighbourhoods with intense visceral leishmaniasis transmission in Fortaleza and Montes Claros...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
Luisa Z Moreno, Fabiana Miraglia, Ana P Loureiro, Frederico S Kremer, Marcus R Eslabao, Odir A Dellagostin, Walter Lilenbaum, Silvio A Vasconcellos, Marcos B Heinemann, Andrea M Moreno
Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
Yanouk Epelboin, Sarah C Chaney, Amandine Guidez, Nausicaa Habchi-Hanriot, Stanislas Talaga, Lanjiao Wang, Isabelle Dusfour
Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniques. This review summarises the history of vector control in French Guiana by reporting the records found in the private archives of the Institute Pasteur in French Guiana and those accessible in libraries worldwide...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
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