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Memórias do Instituto Oswaldo Cruz

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https://www.readbyqxmd.com/read/29768625/detection-of-blandm-1-in-stenotrophomonas-maltophilia-isolated-from-brazilian-soil
#1
João Pedro Rueda Furlan, André Pitondo-Silva, Eliana Guedes Stehling
This study reports the presence of the blaNDM-1 gene in an isolate of Stenotrophomonas maltophilia obtained from a Brazilian soil, inside an IncA/C plasmid with ~ 45 Kb. To the best of our knowledge, this is the second report in the world and the first in Brazil of NDM-producing bacterium isolated from soil.
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768624/analysis-of-the-immunological-biomarker-profile-during-acute-zika-virus-infection-reveals-the-overexpression-of-cxcl10-a-chemokine-linked-to-neuronal-damage
#2
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768623/entomological-investigation-of-japanese-encephalitis-outbreak-in-malkangiri-district-of-odisha-state-india
#3
Sudhansu Sekhar Sahu, Smrutidhara Dash, Thankachy Sonia, Subramaniam Muthukumaravel, Thirumal Sankari, Kasinathan Gunasekaran, Purushothaman Jambulingam
BACKGROUND: A severe outbreak of Japanese encephalitis (JE) and acute encephalitis syndrome (AES) with high case fatality was reported from Malkangiri district of Odisha state, India during September to November 2016 affecting 336 children with 103 deaths. OBJECTIVES: The purpose of this study was to investigate the outbreak in the light of entomological determinants. METHODS: Entomological investigation was carried out in 48 villages from four mostly affected Community Health Centres (CHCs) of Malkangiri district...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768622/single-nucleotide-polymorphisms-of-cytokine-related-genes-and-association-with-clinical-outcome-in-a-chagas-disease-case-control-study-from-brazil
#4
Lucia Elena Alvarado-Arnez, Angelica Martins Batista, Silvia Marinho Alves, Gloria Melo, Virgínia Maria Barros de Lorena, Cynthia C Cardoso, Isabela Resende Pereira, Cristina Carrazzone, Antonio G Pacheco, Wilson Oliveira, Milton Ozório Moraes, Joseli Lannes-Vieira
BACKGROUND: The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768531/effect-of-vegetation-on-cutaneous-leishmaniasis-in-paran%C3%A3-brazil
#5
Helen Aline Melo, Diogo Francisco Rossoni, Ueslei Teodoro
BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in the state of Paraná, Brazil. OBJECTIVE: This study aimed at analysing the influence of the remaining native vegetation on the prevalence of CL in Paraná. METHODS: Global testing was used for spatial autocorrelation along with simultaneous autoregressive model (SAR). The regression was based on the CL coefficient (cases/100,000 inhabitants) as a function of the percentage of natural vegetation cover, altitude, total number of cases, and spatial density (SD) per km2; the location data of the Paraná state municipalities and the detection coefficient (DC) (cases/100,000 inhabitants) of autochthonous cases of CL were obtained from the SINAN in 2012 and 2016...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768530/ns1-codon-usage-adaptation-to-humans-in-pandemic-zika-virus
#6
Caio César de Melo Freire, Giuseppe Palmisano, Carla T Braconi, Fernanda R Cugola, Fabiele B Russo, Patricia Cb Beltrão-Braga, Atila Iamarino, Daniel Ferreira de Lima Neto, Amadou Alpha Sall, Livia Rosa-Fernandes, Martin R Larsen, Paolo Marinho de Andrade Zanotto
BACKGROUND: Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome...
May 10, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/26676376/erratum-trichuris-trichiura-in-a-post-colonial-brazilian-mummy
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29590236/evaluation-of-the-recombinant-antigens-wb14-and-wbt-for-the-capture-antibody-diagnosis-of-lymphatic-filariasis
#8
André Filipe Pastor, Abraham Rocha, Klécia de Melo Cassemiro, Marli Tenório, Paula Melo, Maria Rosângela Grilis, Maressa Rhuama, Antonio Mauro Rezende, Osvaldo Pompilio de Melo Neto, Ernesto Marques, Rafael Dhalia
BACKGROUND: Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity) and limited diagnostic kits. OBJECTIVES: The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT) as part of an enzyme-linked immunosorbent assay (ELISA) based antibody capture tests for LF...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29590235/effectiveness-of-dog-collars-impregnated-with-4-deltamethrin-in-controlling-visceral-leishmaniasis-in-lutzomyia-longipalpis-diptera-psychodidade-phlebotominae-populations
#9
Rafaella Albuquerque E Silva, Andrey José de Andrade, Bruno Beust Quint, Gabriel Elias Salmen Raffoul, Guilherme Loureiro Werneck, Elizabeth Ferreira Rangel, Gustavo Adolfo Sierra Romero
BACKGROUND: There is little information on the effect of using deltamethrin-impregnated dog collars for the control of canine visceral leishmaniasis. OBJECTIVES: The objective of this study was to evaluate the effectiveness of the use of 4% deltamethrin-impregnated collars (Scalibor®) in controlling visceral leishmaniasis in Lutzomyia longipalpis by comparing populations in intervention and non-intervention areas. METHODS: Phlebotomine flies were captured over 30 months in four neighbourhoods with intense visceral leishmaniasis transmission in Fortaleza and Montes Claros...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29538491/genomic-characterisation-of-leptospira-inadai-serogroup-lyme-isolated-from-captured-rat-in-brazil-and-comparative-analysis-with-human-reference-strain
#10
Luisa Z Moreno, Fabiana Miraglia, Ana P Loureiro, Frederico S Kremer, Marcus R Eslabao, Odir A Dellagostin, Walter Lilenbaum, Silvio A Vasconcellos, Marcos B Heinemann, Andrea M Moreno
Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29538490/successes-and-failures-of-sixty-years-of-vector-control-in-french-guiana-what-is-the-next-step
#11
Yanouk Epelboin, Sarah C Chaney, Amandine Guidez, Nausicaa Habchi-Hanriot, Stanislas Talaga, Lanjiao Wang, Isabelle Dusfour
Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniques. This review summarises the history of vector control in French Guiana by reporting the records found in the private archives of the Institute Pasteur in French Guiana and those accessible in libraries worldwide...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412361/entomopathogenic-fungi-and-their-potential-for-the-management-of-aedes-aegypti-diptera-culicidae-in-the-americas
#12
Harry C Evans, Simon L Elliot, Robert W Barreto
Classical biological control has been used extensively for the management of exotic weeds and agricultural pests, but never for alien insect vectors of medical importance. This simple but elegant control strategy involves the introduction of coevolved natural enemies from the centre of origin of the target alien species. Aedes aegypti - the primary vector of the dengue, yellow fever and Zika flaviviruses - is just such an invasive alien in the Americas where it arrived accidentally from its West African home during the slave trade...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412360/lutzomyia-umbratilis-from-an-area-south-of-the-negro-river-is-refractory-to-in-vitro-interaction-with-leishmania-guyanensis
#13
Rodrigo Pedro Soares, Paula Monalisa Nogueira, Nágila Francinete Secundino, Eric Fabrício Marialva, Cláudia Maria Ríos-Velásquez, Felipe Arley Costa Pessoa
BACKGROUND: Lutzomyia umbratilis, the vector for Leishmania guyanensis in northern South America, has been found naturally infected with L. guyanensis only in areas north of the Negro and Amazon rivers. While populations of this sand fly species are also found in areas south of these rivers, these populations have never been reported to be infected and/or transmitting L. guyanensis. However, no studies on the corresponding host-parasite interactions are available. OBJECTIVES: This study evaluated the interaction between Lu...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412359/potential-application-of-rlc36-protein-for-diagnosis-of-canine-visceral-leishmaniasis
#14
Camila Tita Nogueira, Mayara Lúcia Del Cistia, Ana Carolina Urbaczek, Márcia Mg Jusi, Angela Maria Arenas Velásquez, Rosângela Zacarias Machado, Henrique Ferreira, Flávio Henrique-Silva, Hélio Langoni, Paulo Inácio da Costa, Márcia As Graminha
Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412358/feline-sporotrichosis-associations-between-clinical-epidemiological-profiles-and-phenotypic-genotypic-characteristics-of-the-etiological-agents-in-the-rio-de-janeiro-epizootic-area
#15
Jéssica Sepulveda Boechat, Manoel Marques Evangelista Oliveira, Rodrigo Almeida-Paes, Isabella Dib Ferreira Gremião, Ana Caroline de Sá Machado, Raquel de Vasconcelos Carvalhaes Oliveira, Anna Barreto Fernandes Figueiredo, Vanessa Brito de Souza Rabello, Karoline Benevides de Lima Silva, Rosely Maria Zancopé-Oliveira, Tânia Maria Pacheco Schubach, Sandro Antonio Pereira
BACKGROUND: Sporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely. OBJECTIVES: To characterise the clinical isolates from cats at the species level and correlate them with the clinical and epidemiological characteristics of the cats...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412357/identification-of-the-alpha-enolase-p46-in-the-extracellular-membrane-vesicles-of-bacteroides-fragilis
#16
Thais Gonçalves Ferreira, Camilla Nunes Dos Reis Trindade, Petra Bell, André Teixeira-Ferreira, Jonas E Perales, Rossiane C Vommaro, Regina Maria Cavalcanti Pilotto Domingues, Eliane de Oliveira Ferreira
BACKGROUND: Members of the Bacteroides fragilis group are the most important components of the normal human gut microbiome, but are also major opportunistic pathogens that are responsible for significant mortality, especially in the case of bacteraemia and other severe infections, such as intra-abdominal abscesses. Up to now, several virulence factors have been described that might explain the involvement of B. fragilis in these infections. The secretion of extracellular membrane vesicles (EMVs) has been proposed to play a role in pathogenesis and symbiosis in gram-negative bacteria, by releasing soluble proteins and other molecules...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412356/sensitivity-of-diagnostic-methods-for-mansonella-ozzardi-microfilariae-detection-in-the-brazilian-amazon-region
#17
COMPARATIVE STUDY
Jansen Fernandes Medeiros, Gilberto Fontes, Vilma Lopes do Nascimento, Moreno Rodrigues, Jacob Cohen, Edmar Vaz de Andrade, Felipe Arley Costa Pessoa, Marilaine Martins
BACKGROUND: The human filarial worm Mansonella ozzardi is highly endemic in the large tributaries of the Amazon River. This infection is still highly neglected and can be falsely negative when microfilariae levels are low. OBJECTIVES: This study investigated the frequency of individuals with M. ozzardi in riverine communities in Coari municipality, Brazilian Amazon. METHODS: Different diagnostic methods including polymerase chain reaction (PCR), blood polycarbonate membrane filtration (PCMF), Knott's method (Knott), digital thick blood smears (DTBS) and venous thick blood smears (VTBS) were used to compare sensitivity and specificity among the methods...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412355/paracoccidioidomycosis-due-to-paracoccidioides-brasiliensis-s1-plus-hiv-co-infection
#18
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Hugo Boechat Andrade, Ana Beatriz Teixeira Brandão Camello Ferreira, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
BACKGROUND: Paracoccidioidomycosis (PCM) is one of the most important systemic mycoses in Latin America and the leading fungal cause of mortality in non-immunosuppressed individuals in Brazil. However, HIV/PCM co-infection can increase the clinical severity in these co-infected patients. This co-infection is rarely reported in the literature mainly because of the different epidemiological profiles of these infections. Furthermore, PCM is a neglected and non-notifiable disease, which may underestimate the real importance of this disease...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412354/mycobacterium-tuberculosis-promotes-genomic-instability-in-macrophages
#19
COMPARATIVE STUDY
Jorge Castro-Garza, Miriam Lorena Luévano-Martínez, Licet Villarreal-Treviño, Jaime Gosálvez, José Luis Fernández, Martha Imelda Dávila-Rodríguez, Catalina García-Vielma, Silvia González-Hernández, Elva Irene Cortés-Gutiérrez
BACKGROUND: Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES: To evaluate the genomic instability of M. tuberculosis-infected macrophages and compare it with that of uninfected macrophages. METHODS: We analysed the possible variations in the genomic instability of Mycobacterium-infected macrophages using the DNA breakage detection fluorescence in situ hybridisation (DBD-FISH) technique with a whole human genome DNA probe...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412353/looking-for-combination-of-benznidazole-and-trypanosoma-cruzi-triosephosphate-isomerase-inhibitors-for-chagas-disease-treatment
#20
Elena Aguilera, Javier Varela, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa Vera de Bilbao, Hugo Cerecetto, Guzmán Alvarez, Mercedes González
BACKGROUND: The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES: Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three new synthetic T. cruzi-triosephosphate isomerase inhibitors, 2, 3, and 4, in order to potentiate their actions. METHODS: The in vitro effect of the drug combinations were determined constructing the corresponding isobolograms...
March 2018: Memórias do Instituto Oswaldo Cruz
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