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Memórias do Instituto Oswaldo Cruz

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https://www.readbyqxmd.com/read/27878214/lethal-and-sublethal-effects-of-essential-oil-of-lippia-sidoides-verbenaceae-and-monoterpenes-on-chagas-disease-vector-rhodnius-prolixus
#1
Marcela B Figueiredo, Geovany A Gomes, Jayme M Santangelo, Emerson G Pontes, Patricia Azambuja, Elói S Garcia, Mário G de Carvalho
The aim of this study was to identify the composition of the essential oil from leaves of Lippia sidoides (EOLS), a typical shrub commonly found in the dry northeast of Brazil, popularly known as "alecrim-pimenta". Additionally, we investigated the nymphicidal, ovicidal, phagoinhibitory and excretion effects of EOLS, its major constituent thymol and its isomer carvacrol, on fourth instar nymphs and eggs of Rhodnius prolixus, the Chagas' disease vector. The nymphicidal and ovicidal activity of thymol, carvacrol, and EOLS was assessed by tests using impregnated Petri dishes...
November 21, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27849221/prevalence-of-trypanosoma-cruzi-infection-among-bolivian-immigrants-in-the-city-of-s%C3%A3-o-paulo-brazil
#2
Expedito Ja Luna, Celia R Furucho, Rubens A Silva, Dalva M Wanderley, Noemia B Carvalho, Camila G Satolo, Ruth M Leite, Cassio Silveira, Lia Mb Silva, Fernando M Aith, Nivaldo Carneiro, Maria A Shikanai-Yasuda
With the urbanisation of the population in developing countries and the process of globalisation, Chagas has become an emerging disease in the urban areas of endemic and non-endemic countries. In 2006, it was estimated that the prevalence of Chagas disease among the general Bolivian population was 6.8%. The aim of the present study was to determine the prevalence of Trypanosoma cruzi infection among Bolivian immigrants living in São Paulo, Brazil. This study had a sample of 633 volunteers who were randomly selected from the clientele of primary care units located in the central districts of São Paulo, Brazil...
November 16, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27849220/surveillance-of-antiviral-resistance-markers-in-argentina-detection-of-e119v-neuraminidase-mutation-in-a-post-treatment-immunocompromised-patient
#3
Andrea Pontoriero, Martín Avaro, Estefania Benedetti, Mara Russo, Andrea Czech, Natalia Periolo, Ana Campos, Ana Zamora, Elsa Baumeister
Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample collected from an immunocompromised patient in Argentina...
November 16, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27849219/genomic-and-phylogenetic-evidence-of-viper-retrotransposon-domestication-in-trypanosomatids
#4
Adriana Ludwig, Marco Aurelio Krieger
Transposable elements are important residents of eukaryotic genomes and eventually the host can domesticate them to serve cellular functions. We reported here a possible domestication event of the vestigial interposed retroelement (VIPER) in trypanosomatids. We found a large gene in a syntenic location in Leishmania braziliensis, L. panamensis, Leptomanas pyrrhocoris, and Crithidia fasciculata whose products share similarity in the C-terminal portion with the third protein of VIPER. No remnants of other VIPER regions surrounding the gene sequence were found...
November 16, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27812602/a-non-hepatotropic-parasite-infection-increases-mortality-in-the-acetaminophen-induced-acute-liver-failure-murine-model-possible-roles-for-il-5-and-il-6
#5
Marco A De León-Nava, Carolina Álvarez-Delgado, Luis Donis-Maturano, Joselin Hernández-Ruiz, Aaron N Manjarrez-Reyna, Edgar Cruz-Avilés, Sonia Leon-Cabrera, Jorge Morales-Montor, José M Fragoso, Galileo Escobedo
We evaluated the effects of a non-hepatotropic parasite infection (Taenia crassiceps) on the outcome of acetaminophen-induced acute liver failure in mice. Uninfected and T. crassiceps infected mice orally received either 300 mg/kg acetaminophen or water as vehicle (n = 5 per group). Survival analysis, hepatocyte necrosis, alanine aminotransferase (ALT) levels, CYP2E1 protein, interleukin (IL-) 5, and IL-6 were assessed for all groups. All infected mice died within 16 h after exposure to acetaminophen (Tc+APAP group), whereas only one-third of uninfected animals exposed to acetaminophen (APAP group) died...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27812601/pyriproxyfen-and-the-microcephaly-epidemic-in-brazil-an-ecological-approach-to-explore-the-hypothesis-of-their-association
#6
Maria de Fatima P Militão de Albuquerque, Wayner V de Souza, Antônio da Cruz G Mendes, Tereza M Lyra, Ricardo Aa Ximenes, Thália Vb Araújo, Cynthia Braga, Demócrito B Miranda-Filho, Celina Mt Martelli, Laura C Rodrigues
The microcephaly epidemic in Brazil generated intense debate regarding its causality, and one hypothesised cause of this epidemic, now recognised as congenital Zika virus syndrome, was the treatment of drinking water tanks with pyriproxyfen to control Aedes aegypti larvae. We present the results of a geographical analysis of the association between the prevalence of microcephaly confirmed by Fenton growth charts and the type of larvicide used in the municipalities that were home to the mothers of the affected newborns in the metropolitan region of Recife in Pernambuco, the state in Brazil where the epidemic was first detected...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27812600/analysis-of-e2-gene-integrity-in-hpv16-and-hpv58-viruses-isolated-from-women-with-cervical-pathology
#7
María Del R González-Losa, Marylin Puerto-Solis, Juan Tenorio Ruiz, Ariel I Rosado-López, Oscar Hau-Aviles, Guadalupe Ayora-Talavera, Isidro Cisneros-Cutz, Laura Conde-Ferráez
Integration of human papillomavirus (HPV) DNA into human cells accompanied by the disruption of the viral genome has been described as a prerequisite for cancer development. This study aimed to investigate E2 gene integrity of HPV16 and HPV58 viruses isolated from infected women with cervical lesions. Forty-two HPV16- and 31 HPV58-positive samples were analysed. E2 integrity was assumed when all fragments covering the E2 gene were amplified with specific polymerase chain reaction primers. Overall, in 59% of the samples, at least one fragment was not amplified in HPV16- (57%) and HPV58-positive samples (61%)...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27812599/molecular-evidence-of-high-risk-human-papillomavirus-infection-in-colorectal-tumours-from-cuban-patients
#8
Yudira Soto, Celia Maria Limia, Licet González, Bienvenido Grá, Olga Marina Hano, Pedro Ariel Martínez, Vivian Kourí
The association between colorectal cancer and human papillomavirus (HPV) infection is still unproven. The aim of this study was to investigate the presence of high-risk HPV (HR-HPV) DNA in colorectal tissues from Cuban patients. A total of 63 colorectal formalin-fixed paraffin-embedded tissues were studied (24 adenocarcinoma, 18 adenoma, and 21 colorectal tissues classified as benign colitis). DNA from colorectal samples was analysed by quantitative real-time polymerase chain reaction to detect the most clinically relevant high HR-HPV types (HPV-16, -18, -31, -33, -45, -52, and -58)...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27812598/draft-genome-sequences-of-four-achromobacter-ruhlandii-strains-isolated-from-cystic-fibrosis-patients
#9
Elenice Ra Rodrigues, Géssica A Rocha, Alex G Ferreira, Robson S Leão, Rodolpho M Albano, Elizabeth A Marques
Achromobacter species are being increasingly isolated from the respiratory tract of cystic fibrosis patients. Recent reports indicate that Achromobacter ruhlandii is a potential human pathogen in cystic fibrosis-related infections. Here we report the draft genome of four A. ruhlandii strains isolated from cystic fibrosis patients in Brazil. This report describes A. ruhlandii as a potential opportunistic pathogen in cystic fibrosis and provides a framework to for additional enquires into potential virulence factors and resistance mechanisms within this species...
October 31, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783720/distribution-of-the-members-of-the-pipiens-assemblage-in-the-sympatric-area-from-argentina-which-is-where-and-when
#10
María V Cardo, Alejandra Rubio, Melania Junges, Darío Vezzani, Aníbal E Carbajo
Given their medical and veterinary relevance, the members of the Pipiens Assemblage are a worldwide target of ecological research. The distribution of Culex pipiens s.s. and Cx. quinquefasciatus converge in Buenos Aires, Argentina, where hybrids have been detected. Each member of the assemblage exhibits a distinct eco-physiological behaviour that can affect its efficiency in pathogen transmission. Our aim was to identify the environmental drivers for the spatio-temporal distribution of each member, focusing on latitudinal and urbanisation gradients...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783719/nicotinamide-mononucleotide-adenylyltransferase-of-trypanosoma-cruzi-tcnmnat-a-cytosol-protein-target-for-serine-kinases
#11
Diana Milena Sánchez-Lancheros, Luis Fernando Ospina-Giraldo, María Helena Ramírez-Hernández
Nicotinamide/nicotinate adenine dinucleotide (NAD+/NaAD) performs essential functions in cell metabolism and energy production due to its redox properties. The nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) enzyme catalyses the key step in the biosynthesis of NAD+. Previously, the enzyme NMNAT was identified in Trypanosoma cruzi (TcNMNAT), a pathogenic agent with epidemiological importance in Latin America. To continue with the functional characterisation of this enzyme, its subcellular location and its possible post-translational modifications were examined in this study...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783718/up-regulation-of-atp-binding-cassette-transporters-in-the-thp-1-human-macrophage-cell-line-by-the-antichagasic-benznidazole
#12
Virginia G Perdomo, Juan P Rigalli, Marcelo G Luquita, José M Pellegrino, María Laura Ruiz, Viviana A Catania
The effect of benznidazole (BZL) on the expression and activity of P-glycoprotein (P-gp, ABCB1) and multidrug resistance-associated protein 2 (MRP2, ABCC2), the two major transporters of endogenous and exogenous compounds, was evaluated in differentiated THP-1 cells. BZL induced P-gp and MRP2 proteins in a concentration-dependent manner. The increase in mRNA levels of both transporters suggests transcriptional regulation. P-gp and MRP2 activities correlated with increased protein levels. BZL intracellular accumulation was significantly lower in BZL-pre-treated cells than in control cells...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27783717/influence-of-il-6-il-8-and-tgf-%C3%AE-1-gene-polymorphisms-on-the-risk-of-human-papillomavirus-infection-in-women-from-pernambuco-brazil
#13
Sérgio Ferreira de Lima, Mayara Mansur Fernandes Tavares, Jamilly Lopes de Macedo, Renata Santos de Oliveira, Sandra de Andrade Heráclio, Maria de Mascena Diniz Maia, Paulo Roberto Eleutério de Souza, Ronald Moura, Sergio Crovella
Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27759770/mapping-of-courses-on-vector-biology-and-vector-borne-diseases-systems-time-for-a-worldwide-effort
#14
Jérôme Casas, Claudio Lazzari, Teresita Insausti, Pascal Launois, Florence Fouque
Major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. The discrepancy between the rates of production of knowledge and its use and need for solving crises is widening, in particular due to the highly differing time spans of the two concurrent processes. A worldwide web based search using multiple key words and search engines of onsite and online courses in English, Spanish, Portuguese, French, Italian and German concerned with the biology of vectors identified over 140 courses...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27759769/hepatitis-e-virus-infection-in-patients-with-acute-non-a-non-b-non-c-hepatitis-in-central-brazil
#15
Nara Rubia de Freitas, Edna Braz Rocha de Santana, Ágabo Macedo da Costa E Silva, Sueli Meira da Silva, Sheila Araújo Teles, Noemi Rovaris Gardinali, Marcelo Alves Pinto, Regina Maria Bringel Martins
Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27759768/immune-response-in-hamsters-immunised-with-a-recombinant-fragment-of-liga-from-leptospira-interrogans-associated-with-carrier-molecules
#16
Thaís L Oliveira, Kátia L Bacelo, Rodrigo A Schuch, Fabiana K Seixas, Tiago Collares, Oscar Ed Rodrigues, Josimar Vargas, Rafaella O do Nascimento, Odir A Dellagostin, Daiane D Hartwig
Immunisation with the C-terminal region of leptospiral immunoglobulin-like A protein (LigANI) has shown promising results against leptospirosis. We evaluated the humoral immune response and protection induced by LigANI associated with carboxyl multi-walled carbon nanotubes (COOH-MWCNTs), CpG oligodeoxynucleotides (CpG ODNs), or Alhydrogel. Animals immunised with CpG ODNs were unable to develop a humoral immune response, whereas immunisation with LigANI and COOH-MWCNTs produced a high level of IgG antibodies, similar to that with LigANI and Alhydrogel, but it was not protective...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27759767/triatoma-maculata-colonises-urban-domicilies-in-boa-vista-roraima-brazil
#17
Alice Ricardo-Silva, Teresa Cristina Monte Gonçalves, José Francisco Luitgards-Moura, Catarina Macedo Lopes, Silvano Pedrosa da Silva, Amanda Queiroz Bastos, Nathalia Coelho Vargas, Maria-Rosa Goreti Freitas
During a medical entomology course in Boa Vista, Roraima, colonies of Triatoma maculata closely associated with pigeon nests were observed in concrete air-conditioner box located on the external plastered and cemented walls of a modern brick-built apartment block. In only one eight-hole ceramic brick, located inside one air-conditioner box, 127 specimens of T. maculata were collected. T. maculata is a recognised vector of Trypanosoma cruzi in the surrounding area and its domiciliation increases the risk of Chagas disease transmission...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27706381/culture-media-profoundly-affect-candida-albicans-and-candida-tropicalis-growth-adhesion-and-biofilm-development
#18
Manjula M Weerasekera, Gayan K Wijesinghe, Thilini A Jayarathna, Chinthika P Gunasekara, Neluka Fernando, Nilwala Kottegoda, Lakshman P Samaranayake
As there are sparse data on the impact of growth media on the phenomenon of biofilm development for Candida we evaluated the efficacy of three culture media on growth, adhesion and biofilm formation of two pathogenic yeasts, Candida albicans and Candida tropicalis. The planktonic phase yeast growth, either as monocultures or mixed cultures, in sabouraud dextrose broth (SDB), yeast nitrogen base (YNB), and RPMI 1640 was compared, and adhesion as well as biofilm formation were monitored using MTT and crystal violet (CV) assays and scanning electron microscopy...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27706380/symbiont-modulates-expression-of-specific-gene-categories-in-angomonas-deanei
#19
Luciana Loureiro Penha, Luísa Hoffmann, Silvanna Sant'Anna de Souza, Allan Cézar de Azevedo Martins, Thayane Bottaro, Francisco Prosdocimi, Débora Souza Faffe, Maria Cristina Machado Motta, Turán Péter Ürményi, Rosane Silva
Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosynthesis. Angomonas deanei is an example of a symbiont-containing trypanosomatid. In this paper, we sought to investigate how symbionts influence host cells by characterising and comparing the transcriptomes of the symbiont-containing A. deanei (wild type) and the symbiont-free aposymbiotic strains...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27759766/vancomycin-intermediate-livestock-associated-methicillin-resistant-staphylococcus-aureus-st398-t9538-from-swine-in-brazil
#20
Luisa Z Moreno, Mauricio C Dutra, Marina Moreno, Thais Sp Ferreira, Givago Fr da Silva, Carlos Ec Matajira, Ana Paula S Silva, Andrea M Moreno
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has been mainly related with pig farming, in Europe and North America, with the ST398 as the most commonly identified type of LA-MRSA. Here we present the draft genome of the first vancomycin-intermediate MRSA ST398/t9538 isolated from a swine presenting exudative epidermitis in Brazil.
October 2016: Memórias do Instituto Oswaldo Cruz
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