journal
MENU ▼
Read by QxMD icon Read
search

Memórias do Instituto Oswaldo Cruz

journal
https://www.readbyqxmd.com/read/28876359/tracing-the-origin-of-the-ns1-a188v-substitution-responsible-for-recent-enhancement-of-zika-virus-asian-genotype-infectivity
#1
Edson Delatorre, Daiana Mir, Gonzalo Bello
A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas...
September 4, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28954002/characterisation-of-complete-high-and-low-risk-human-papillomavirus-genomes-isolated-from-cervical-specimens-in-southern-brazil
#2
Gisele R de Oliveira, Juliana D Siqueira, Fabiana Finger-Jardim, Valdimara C Vieira, Ronald L Silva, Carla V Gonçalves, Esmeralda A Soares, Ana Maria Barral de Martinez, Marcelo A Soares
The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28954001/glimpse-into-the-genome-sequence-of-a-multidrug-resistant-acinetobacter-pittii-st950-clinical-isolate-carrying-the-blaoxa-72-and-blaoxa-533-genes-in-china
#3
Zhi Ruan, Yan Chen, Jianfeng Wang
The development of carbapenem-resistant Acinetobacter species is of serious concern in the hospital settings and naturally occurring oxacillinase genes (blaOXA) have been identified in several Acinetobacter species. In this study, we report the genome sequence of A. pittii TCM178 belongs to ST950, a multidrug-resistant isolate that harbored the blaOXA-72 and blaOXA-533 genes simultaneous. The genome size was estimated to be 3,789,564 bp with 3,501 predicted coding regions, and G+C content is 37.60%. Our findings have raised awareness of the possible constitution of a reservoir for peculiar carbapenemase genes in A...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28954000/emergence-of-trichosporon-mycotoxinivorans-apiotrichum-mycotoxinivorans-invasive-infections-in-latin-america
#4
João Nobrega de Almeida, Elaine Cristina Francisco, Maria Goreth M de Andrade Barberino, Luiz Vicente Ribeiro F da Silva, Oriana M Brandão, Arnaldo Lopes Colombo, Ana Carolina Barbosa Padovan
We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. A review of the relevant literature revealed that deep-seated infections were related to immunosuppression or invasive devices, while most of the CF patients showed a decline in lung function after positive cultures...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953999/multi-criteria-decision-analysis-and-spatial-statistic-an-approach-to-determining-human-vulnerability-to-vector-transmission-of-trypanosoma-cruzi
#5
Diego Montenegro, Ana Paula da Cunha, Simone Ladeia-Andrade, Mauricio Vera, Marcel Pedroso, Angela Junqueira
BACKGROUND: Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected human disease. It is endemic to the Americas and is estimated to have an economic impact, including lost productivity and disability, of 7 billion dollars per year on average. OBJECTIVES: To assess vulnerability to vector-borne transmission of T. cruzi in domiciliary environments within an area undergoing domiciliary vector interruption of T. cruzi in Colombia. METHODS: Multi-criteria decision analysis [preference ranking method for enrichment evaluation (PROMETHEE) and geometrical analysis for interactive assistance (GAIA) methods] and spatial statistics were performed on data from a socio-environmental questionnaire and an entomological survey...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953998/the-eco-epidemiology-of-triatoma-infestans-in-the-temperate-monte-desert-ecoregion-of-mid-western-argentina
#6
Ana Laura Carbajal-de-la-Fuente, Yael Mariana Provecho, María Del Pilar Fernández, Marta Victoria Cardinal, Patricia Lencina, Cynthia Spillmann, Ricardo Esteban Gürtler
BACKGROUND: The eco-epidemiological status of Chagas disease in the Monte Desert ecoregion of western Argentina is largely unknown. We investigated the environmental and socio-demographic determinants of house infestation with Triatoma infestans, bug abundance, vector infection with Trypanosoma cruzi and host-feeding sources in a well-defined rural area of Lavalle Department in the Mendoza province. METHODS: Technical personnel inspected 198 houses for evidence of infestation with T...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953997/antimycobacterial-and-antimalarial-activities-of-endophytic-fungi-associated-with-the-ancient-and-narrowly-endemic-neotropical-plant-vellozia-gigantea-from-brazil
#7
Mariana C Ferreira, Charles L Cantrell, David E Wedge, Vívian N Gonçalves, Melissa R Jacob, Shabana Khan, Carlos A Rosa, Luiz H Rosa
BACKGROUND: Endophytic fungi, present mainly in the Ascomycota and Basidiomycota phyla, are associated with different plants and represent important producers of bioactive natural products. Brazil has a rich biodiversity of plant species, including those reported as being endemic. Among the endemic Brazilian plant species, Vellozia gigantea (Velloziaceae) is threatened by extinction and is a promising target to recover endophytic fungi. OBJECTIVE: The present study focused on bioprospecting of bioactive compounds of the endophytic fungi associated with V...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953996/the-role-of-gallery-forests-in-maintaining-phlebotominae-populations-potential-leishmania-spp-vectors-in-the-brazilian-savanna
#8
Tâmara Dias Oliveira Machado, Thaís Tâmara Castro Minuzzi-Souza, Tauana de Sousa Ferreira, Luciana Pereira Freire, Renata Velôzo Timbó, Tamires Emanuele Vital, Nadjar Nitz, Mariana Neiva Silva, Alcinei de Souza Santos, Nathyla Morgana Cunha Sales, Marcos Takashi Obara, Andrey José de Andrade, Rodrigo Gurgel-Gonçalves
BACKGROUND: Knowledge on synanthropic phlebotomines and their natural infection by Leishmania is necessary for the identification of potential areas for leishmaniasis occurrence. OBJECTIVE: To analyse the occurrence of Phlebotominae in gallery forests and household units (HUs) in the city of Palmas and to determine the rate of natural infection by trypanosomatids. METHODS: Gallery forests and adjacent household areas were sampled on July (dry season) and November (rainy season) in 2014...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953995/environmental-suitability-for-lutzomyia-longipalpis-in-a-subtropical-city-with-a-recently-established-visceral-leishmaniasis-transmission-cycle-argentina
#9
Pablo Berrozpe, Daniela Lamattina, María Soledad Santini, Analía Vanesa Araujo, María Eugenia Utgés, Oscar Daniel Salomón
BACKGROUND: Visceral leishmaniasis (VL) is an endemic disease in northeastern Argentina including the Corrientes province, where the presence of the vector and canine cases of VL were recently confirmed in December 2008. OBJECTIVES: The objective of this study was to assess the modelling of micro- and macro-habitat variables to evaluate the urban environmental suitability for the spatial distribution of Lutzomyia longipalpis presence and abundance in an urban scenario...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953994/morphologic-study-of-the-effect-of-iron-on-pseudocyst-formation-in-trichomonas-vaginalis-and-its-interaction-with-human-epithelial-cells
#10
Geovane Dias-Lopes, Leonardo Saboia-Vahia, Eliane Trindade Margotti, Nilma de Souza Fernandes, Cássia Luana de Faria Castro, Francisco Odencio Oliveira, Juliana Figueiredo Peixoto, Constança Britto, Fernando Costa E Silva, Patricia Cuervo, José Batista de Jesus
BACKGROUND: Trichomonas vaginalis is the aetiological agent of human trichomoniasis, which is one of the most prevalent sexually transmitted diseases in humans. Iron is an important element for the survival of this parasite and the colonisation of the host urogenital tract. OBJECTIVES: In this study, we investigated the effects of iron on parasite proliferation in the dynamics of pseudocyst formation and morphologically characterised iron depletion-induced pseudocysts...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953993/in-silico-analysis-of-amino-acid-variation-in-human-respiratory-syncytial-virus-insights-into-immunodiagnostics
#11
Claudemir Souza, Nilson It Zanchin, Marco A Krieger, Adriana Ludwig
BACKGROUND: The highly contagious nature of human respiratory syncytial virus (HRSV) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem. Thus, a rapid and sensitive diagnostic test for viral detection that can be implemented upon the first appearance of symptoms is needed. The genetic variation of the virus must be considered for immunodiagnostic purposes. OBJECTIVES: To analyse HRSV genetic variation and discuss the possible consequences for capture immunoassay development...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28953992/brazilian-scientific-journals-challenges-dis-incentives-and-one-fundamental-question
#12
EDITORIAL
Adeilton Brandão, Elisa Cupolillo, Claude Pirmez
No abstract text is available yet for this article.
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902292/increased-number-of-deaths-during-a-chikungunya-epidemic-in-pernambuco-brazil
#13
Carlos Alexandre Antunes de Brito, Maria Glória Teixeira
In early 2016, it was suspected that there were more deaths in Pernambuco than in previous years during an epidemic of chikungunya. This study tested whether there was an increased number of deaths and, if so, whether this increase could be related to a chikungunya epidemic. Indeed, there was an increase of 4235 deaths in 2016 compared to the average of the four previous years, and the highest differences were found during the peak period of the epidemic. It was evident that not all of these deaths could be attributed to complications of chikungunya...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902291/emergence-of-methicillin-resistant-staphylococcus-aureus-from-clonal-complex-398-with-no-livestock-association-in-brazil
#14
Egidio Domingos André, Renata Freire Alves Pereira, Robert Eugene Snyder, Thamiris Santana Machado, Lialyz Soares Pereira André, Claudete Aparecida Araújo Cardoso, Fábio Aguiar-Alves
CC398 is a livestock-associated Staphylococcus aureus. However, it has also been isolated from humans with no previous contact with livestock. A surveillance of methicillin-resistant S. aureus colonisation among children attending public day care centres and hospitals in Niterói and Rio de Janeiro, Brazil, between 2011 and 2013, resulted in the isolation of six cases of CC398 from individuals with no previous exposure to livestock. These isolates showed a high frequency of the erm(C) gene (4/6, 66.7%) with induced resistance to clindamycin, and a relatively high frequency of SEs and lukS/lukF genes...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902290/effect-of-secondary-infection-on-epithelialisation-and-total-healing-of-cutaneous-leishmaniasis-lesions
#15
Liliane de Fátima Antonio, Marcelo Rosandiski Lyra, Maurício Naoto Saheki, Armando de Oliveira Schubach, Luciana de Freitas Campos Miranda, Maria de Fátima Madeira, Maria Cristina da Silva Lourenço, Aline Fagundes, Érica Aparecida Dos Santos Ribeiro, Leonardo Barreto, Maria Inês Fernandes Pimentel
BACKGROUND: Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE: This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS: Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902289/exposure-source-prevalence-is-associated-with-gender-in-hepatitis-c-virus-patients-from-rio-de-janeiro-brazil
#16
Daniele Blasquez Olmedo, Patrícia Marraccini Precioso, António Lugdero-Correia, Guida da Silva, Angela Maria Guimarães Dos Santos, Luís Cristóvão Pôrto
BACKGROUND: Hepatitis C virus (HCV) infection is a worldwide public health problem. A characterisation of the differences in exposure sources among genders will enable improvements in surveillance actions. METHODS: Exposure data were obtained for 1180 confirmed HCV cases Brazil's mandatory reporting to epidemiological surveillance, which was directed by a reference laboratory in Rio de Janeiro, Brazil. The Chi-square test (χ2) was used to assess the associations between exposure sources and gender...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902288/basal-core-promoter-and-precore-mutations-among-hepatitis-b-virus-circulating-in-brazil-and-its-association-with-severe-forms-of-hepatic-diseases
#17
Silvana Gama Florencio Chachá, Michele Soares Gomes-Gouvêa, Fernanda de Mello Malta, Sandro da Costa Ferreira, Márcia Guimarães Villanova, Fernanda Fernandes Souza, Andreza Correa Teixeira, Afonso Dinis da Costa Passos, João Renato Rebello Pinho, Ana de Lourdes Candolo Martinelli
BACKGROUND: In Brazil, few studies have investigated the prevalence of infection with the precore (PC) and basal core promoter (BCP) mutants of the hepatitis B virus (HBV). OBJECTIVES: This study aimed to analyse the frequency of PC and BCP mutations among patients infected with HBV and to evaluate the association between the variants and advanced hepatic disease. METHODS: A total of 161 patients infected with HBV were studied. To identify PC and BCP mutations, a 501-bp fragment of HBV DNA was amplified and sequenced...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902287/structural-insights-into-leishmanolysins-encoded-on-chromosome-10-of-leishmania-viannia-braziliensis
#18
Amanda Sutter, Deborah Antunes, Mariana Silva-Almeida, Maurício Garcia de Souza Costa, Ernesto Raul Caffarena
BACKGROUND: Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host's defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in its genome, especially in chromosome 10. However, the functional impact of such diversity is not understood, but may be attributed partially to the lack of structural data for proteins from this parasite. OBJECTIVES: This works aims to compare leishmanolysin sequences from L...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902286/specific-antigen-serologic-tests-in-leprosy-implications-for-epidemiological-surveillance-of-leprosy-cases-and-household-contacts
#19
Ana Paula Mendes Carvalho, Angélica da Conceição Oliveira Coelho, Rodrigo Correa-Oliveira, Francisco Carlos Félix Lana
BACKGROUND: There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE: The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (NDOLID)...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28902285/dipyridamole-potentiated-the-trypanocidal-effect-of-nifurtimox-and-improved-the-cardiac-function-in-nmri-mice-with-acute-chagasic-myocarditis
#20
Sonia Santeliz, Peter Caicedo, Elidiosmar Giraldo, Carmen Alvarez, María-Daniela Yustiz, Claudina Rodríguez-Bonfante, Romina Bonfante-Rodríguez, Rafael Bonfante-Cabarcas
BACKGROUND: As chronic Chagas disease does not have a definitive treatment, the development of alternative therapeutic protocols is a priority. Dipyridamole (DPY) is an alternative to counteract the pathophysiological phenomena involved in Chagas cardiomyopathy. OBJECTIVE: To evaluate the therapeutic efficacy of DPY associated with nifurtimox (Nfx) in epimastigote axenic cultures and in mice with acute Chagas disease. METHODS: NMRI adult male mice were divided into nine groups: three healthy and six Trypanosoma cruzi-infected groups...
September 2017: Memórias do Instituto Oswaldo Cruz
journal
journal
25712
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"