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Memórias do Instituto Oswaldo Cruz

Yao-Ting Huang, Wei-Yao Chuang, Bing-Ching Ho, Zong-Yen Wu, Rita C Kuo, Mengwei Ko, Po-Yu Liu
Raoultella planticola is an emerging zoonotic pathogen that is associated with rare but life-threatening cases of bacteremia, biliary tract infections, and urinary tract infections. Moreover, increasing antimicrobial resistance in the organism poses a potential threat to public health. In spite of its importance as a human pathogen, the genome of R. planticola remains largely unexplored and little is known about its virulence factors. Although lipopolysaccharides has been detected in R. planticola and implicated in the virulence in earlier studies, the genetic background is unknown...
August 27, 2018: Memórias do Instituto Oswaldo Cruz
(no author information available yet)
[This corrects the article doi: 10.1590/0074-0276140228].
August 27, 2018: Memórias do Instituto Oswaldo Cruz
Karine Pedreira Padilha, Maria Eduarda Barreto Resck, Octávio Augusto Talyuli da Cunha, Rayane Teles-de-Freitas, Stéphanie Silva Campos, Marcos Henrique Ferreira Sorgine, Ricardo Lourenço-de-Oliveira, Luana Cristina Farnesi, Rafaela Vieira Bruno
BACKGROUND: Zika has emerged as a new public health threat after the explosive epidemic in Brazil in 2015. It is an arbovirus transmitted mainly by Aedes aegypti mosquitoes. The knowledge of physiological, behavioural and biological features in virus-infected vectors may help the understanding of arbovirus transmission dynamics and elucidate their influence in vector capacity. OBJECTIVES: We aimed to investigate the effects of Zika virus (ZIKV) infection in the behaviour of Ae...
August 23, 2018: Memórias do Instituto Oswaldo Cruz
Henrique S Costa, Marcia Maria O Lima, Pedro Henrique S Figueiredo, Patrícia M Martinelli, Elizabeth Rs Camargos, Ana Thereza Chaves, Maria Carmo Pereira Nunes, Manoel Otavio C Rocha
BACKGROUND: Serum brain-derived neurotrophic factor (BDNF) levels have been shown to be lower in patients with Chagas cardiomyopathy (ChC) than in patients with non-dilated chagasic cardiomyopathy. However, its prognostic value was not established in patients with ChC. METHODS: Forty-nine patients with ChC (50 ± 7 years, New York Heart Association "NYHA" I-III); were evaluated by echocardiography, exercise testing, and blood analysis. Serum BDNF levels were determined using enzyme-linked immunosorbent assay sandwich...
August 20, 2018: Memórias do Instituto Oswaldo Cruz
André Luis Souza Dos Santos, Anna Clara Milesi Galdino, Thaís Pereira de Mello, Lívia de Souza Ramos, Marta Helena Branquinha, Ana Maria Bolognese, José Columbano Neto, Maryam Roudbary
Biofilm formation is the preferred mode of growth lifestyle for many microorganisms, including bacterial and fungal human pathogens. Biofilm is a strong and dynamic structure that confers a broad range of advantages to its members, such as adhesion/cohesion capabilities, mechanical properties, nutritional sources, metabolite exchange platform, cellular communication, protection and resistance to drugs (e.g., antimicrobials, antiseptics, and disinfectants), environmental stresses (e.g., dehydration and ultraviolet light), host immune attacks (e...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Danielle Mann, Flávia Marinho Sant'Anna, Carolina Arana Stanis Schmaltz, Dayvison Francis Saraiva Freitas, Valeria Cavalcanti Rolla, Solange Cesar Cavalcante, Maria Clara Gutierrez-Galhardo
BACKGROUND: Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported. OBJECTIVE: To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. METHODS: We describe a series of 15 CTB and HIV cases, based on secondary data from 2000 to 2016. Diagnosis was based on isolation of Mycobacterium tuberculosis in culture or clinical response to anti-tuberculous treatment associated with positive smear or histopathologic findings from affected skin or an adjacent lymph node...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Douglas de Souza Moreira, Ana Paula Duarte, Fabiano Sviatopolk Mirsky Pais, Rosiane Aparecida da Silva-Pereira, Alvaro José Romanha, Sergio Schenkman, Silvane Maria Fonseca Murta
Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A protein level was 2-fold lower in benznidazole (BZ)-resistant (BZR and 17LER) Trypanosoma cruzi populations than in their respective susceptible counterparts (BZS and 17WTS). To confirm the role of eIF5A in BZ resistance, we transfected BZS and 17WTS with the wild-type eIF5A or mutant eIF5A-S2A (in which serine 2 was replaced by alanine)...
July 26, 2018: Memórias do Instituto Oswaldo Cruz
Roberto Cardoso Ilacqua, Leonardo Suveges Moreira Chaves, Eduardo Sterlino Bergo, Jan E Conn, Maria Anice Mubeb Sallum, Gabriel Zorello Laporta
The Malaria Frontier Hypothesis (MFH) is the current model for predicting malaria emergence in the Brazilian Amazon. It has two important dimensions, 'settlement time' and 'malaria incidence', and its prediction are: malaria incidence peaks five years after the initiation of human settlement and declines towards zero after an estimated 10 years. Although MFH is currently accepted, it has been challenged recently. Herein, we described a novel method for estimating settlement timeline by using remote sensing technology integrated in an open-software geographic information system...
July 23, 2018: Memórias do Instituto Oswaldo Cruz
Guilherme L Werneck, Alejandro E Macias, Cesar Mascarenas, Laurent Coudeville, David Morley, Vincent Recamier, Mariana Guergova-Kuras, Esteban Puentes-Rosas, Nicolas Baurin, Myew-Ling Toh
Dengue remains an unmet public health burden. We determined risk factors for dengue in-hospital mortality in Brazil. Of 326,380 hospitalised dengue cases in 9-45-year-old individuals, there were 971 deaths. Risk of dying was 11-times higher in the presence of underlying common comorbidities (renal, infectious, pulmonary disease and diabetes), similar to the risk of dying from severe dengue and much higher with the combination. Ensuring access to integrated dengue preventative measures in individuals aged ≥ 9 years including those with comorbidities may help achieve the WHO objective of 50% reduction in mortality and 25% reduction in morbidity due to dengue by 2020...
July 23, 2018: Memórias do Instituto Oswaldo Cruz
Olga Lucía Cabrera, Erika Santamaría, Raúl Hernando Pardo
INTRODUCTION: Behavioural effects of insecticides on endophagic phlebotomine sand fly vectors of Leishmania are poorly understood mainly because of the lack of an experimental hut (EH) in which to study them. OBJECTIVE: To build an EH to evaluate the effects of long-lasting insecticide-treated nets (LLINs) on Lutzomyia longiflocosa. METHODS: The study had two phases: (1) Laboratory experiments using tunnel tests to select the traps for the EH; and (2) EH construction and evaluation of the effects of deltamethrin and lambda-cyhalothrin LLINs on L...
July 19, 2018: Memórias do Instituto Oswaldo Cruz
Matías Hernández, Susana Wicz, Miguel H Santamaría, Ricardo S Corral
BACKGROUND: The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi. OBJECTIVE: To evaluate the effects of oral therapy with Cur on T. cruzi-mediated cardiovasculopathy in acutely infected mice and analyse the in vitro response of parasite-infected human microvascular endothelial cells treated with this phytochemical...
July 16, 2018: Memórias do Instituto Oswaldo Cruz
Luis Ernesto Contreras-Rodríguez, Catherin Yizet Marin-Mogollon, Lina Marcela Sánchez-Mejía, María Helena Ramírez-Hernández
The biochemical pathways involved in nicotinamide adenine dinucleotide (NAD) biosynthesis converge at the enzymatic step catalysed by nicotinamide mononucleotide adenylyltransferase (NMNAT, EC: The majority of NMNATs are assembled into homo-oligomeric states that comprise 2-6 subunits. Recently, the NMNAT of Plasmodium falciparum (PfNMNAT) has been identified as a pharmacological target. The enzymatic characterisation, cellular location, and tertiary structure of the PfNMNAT protein have been reported...
July 10, 2018: Memórias do Instituto Oswaldo Cruz
Juliana Nunes Ramos, Izabel Dos Santos Rodrigues, Paulo Victor Pereira Baio, João Flávio Carneiro Veras, Rommel Thiago Jucá Ramos, Luis Gc Pacheco, Vasco Ariston Azevedo, Raphael Hirata Júnior, Michel Abanto Marín, Ana Luiza de Mattos-Guaraldi, Verônica Viana Vieira
Multidrug-resistant (MDR) Corynebacterium striatum has been cited with increased frequency as pathogen of nosocomial infections. In this study, we report the draft genome of a C. striatum isolated from a patient with bloodstream infection in a hospital of Rio de Janeiro, Brazil. The isolate presented susceptibility only to tetracycline, vancomycin and linezolid. The detection of various antibiotic resistance genes is fully consistent with previously observed multidrug-resistant pattern in Corynebacterium spp...
July 10, 2018: Memórias do Instituto Oswaldo Cruz
Edson Machado, Sidra Ezidio Gonçalves Vasconcellos, Camillo Cerdeira, Lia Lima Gomes, Ricardo Junqueira, Luciana Distasio de Carvalho, Jesus Pais Ramos, Paulo Redner, Carlos Eduardo Dias Campos, Paulo Cesar de Souza Caldas, Ana Paula Chaves Sobral Gomes, Telma Goldenberg, Fatima Fandinho Montes, Fernanda Carvalho de Queiroz Mello, Vinicius de Oliveira Mussi, Elena Lasunskaia, Dick van Soolingen, Antonio Basílio de Miranda, Leen Rigouts, Bouke C de Jong, Conor J Meehan, Marcos Catanho, Philip N Suffys
Mycobacterium kansasii is an opportunistic pathogen and one of the most commonly encountered species in individuals with lung disease. We here report the complete genome sequence of 12 clinical isolates of M. kansasii from patients with pulmonary disease in Brazil.
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Lysianne Pinto, Luiz Fernando Zmetek Granja, Mariana Amorim de Almeida, Daniela Sales Alviano, Maria Helena da Silva, Regina Ejzemberg, Sonia Rozental, Celuta Sales Alviano
BACKGROUND: Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America. OBJECTIVE: The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fungal cell ghosts obtained by Novozym 234 treatment on their ability to activate the human complement system...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Marcos César Lima de Mendonça, Maria Angelica Mares-Guia, Cintia Damasceno Dos Santos Rodrigues, Carolina Cardoso Dos Santos, Flavia Lowen Levy Chalhoub, Eliane Saraiva Machado Araújo, Alexandre Otávio Chieppe, Rita Maria Ribeiro Nogueira, Ana Maria Bispo de Filippis
The dengue virus (DENV), of the genus Flavivirus (Flaviviridae), has four antigenically distinct serotypes, of which DENV-3 is classified into five genotypes. Here, we describe the detection of DENV-3 genotype I in sera of a Brazilian patient travelling from Singapore to Rio de Janeiro, Brazil, by using multiplex real-time RT-PCR, DNA sequencing of the whole envelope protein gene, and phylogenetic analysis. The virus shares ancestry with those identified in Bali, Indonesia, in 2015. It is possible that arboviruses such as Chikungunya ECSA genotype, DENV-4 genotype I, and Zika were introduced in Brazil from other continents during the multiple international events hosted by the country over the last four years, including World Youth Day, the Soccer World Cup, and the Summer Olympics...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Paulo Sousa Prado, José Teófilo Duarte Almeida Júnior, Lanna Takada de Abreu, Cristina Gabriel Silva, Larissa da Costa Souza, Marizoneide Cavalcante Gomes, Lucinda Malheiros Teixeira Mendes, Eliane Maria Dos Santos, Gustavo Adolfo Sierra Romero
BACKGROUND: The diagnosis of dengue is complex. Until recently, only specialised laboratories were able to confirm dengue infection. However, this has changed with the newly available immunochromatographic rapid tests. Early diagnosis is of great interest, and point-of-care rapid tests have been increasingly used in Brazil. Most of those tests have not undergone validation in the Brazilian population. In this context, we decided to evaluate a rapid test introduced in the Federal District (FD)...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Dario Brock Ramalho, Rosiana Estéfane da Silva, Maria Camilo Ribeiro de Senna, Hugo Silva Assis Moreira, Mariana Junqueira Pedras, Daniel Moreira de Avelar, Lara Saraiva, Ana Rabello, Gláucia Cota
BACKGROUND: Cutaneous leishmaniasis (CL) is a world-wide health problem which currently lacks effective, affordable and easy to use therapy. Recently, the meglumine antimoniate (MA) intralesional infiltration was included among the acceptable therapies for New World leishmaniasis. While this approach is attractive, there is currently little evidence to support its use in Americas. OBJECTIVES: The aim of this study was to provide information about effectiveness and safety of a standardised MA intralesional infiltration technique for the treatment of CL...
June 21, 2018: Memórias do Instituto Oswaldo Cruz
Bianca Cristina Leires Marques, Mariza Gonçalves Morgado, Monick Lindenmeyer Guimarães
In Brazil, detection of the HIV-1 sub-subtype F1 has decreased with a simultaneous increase in detection of the recombinant FB and FC forms. In previous HIV-1 env molecular epidemiology studies in Rio de Janeiro, 11.4% of the detected sequences were of the F1 sub-subtype. With the goal of re-estimating the prevalence of the HIV-1 F1 sub-subtype, we performed extended analyses of these samples by examining five genomic regions, resulting in 3.3% being confirmed as F1. Moreover, genomic analysis of 11 of the 21 samples identified as F1 confirmed that nine were F1 and two were BF1...
June 11, 2018: Memórias do Instituto Oswaldo Cruz
Marcio Roberto Silva, Adalgiza da Silva Rocha, Flábio Ribeiro Araújo, Antônio Augusto Fonseca-Júnior, Andrea Padilha de Alencar, Philip Noel Suffys, Ronaldo Rodrigues da Costa, Maria Aparecida Scatamburlo Moreira, Mark Drew Crosland Guimarães
BACKGROUND: The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study. OBJECTIVE: The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes...
June 11, 2018: Memórias do Instituto Oswaldo Cruz
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