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JPMA. the Journal of the Pakistan Medical Association

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https://www.readbyqxmd.com/read/27812083/regression-of-hepatocellular-carcinoma-after-treatment-with-sofosbuvir-a-case-report
#1
Shafaq Mahmood, Aleesha Gul, Tayyaba Saif
Spontaneous regression (SR) of hepatocellular carcinoma (HCC) is a rare event. Several factors have been suggested as the underlying mechanism but the exact pathogenesis is not understood. The role of sofosbuvir in HCC regression has not been established yet. We report here a case of a 59 years old male who developed HCC secondary to chronic HCV infection. He failed treatment with interferon but the tumour regressed completely after treatment of hepatitis C with sofosbuvir and ribavirin for 48 weeks.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812082/assessment-of-inhalation-technique-among-patients-of-chronic-respiratory-disorders-in-civil-hospital-karachi-a-cross-sectional-study
#2
Muhammad Zain Farooq, Muhammad Saad Farooq, Wajiha Waqar, Marium Mustaqeem, Javaid Ahmed Khan, Samiyah Saadullah
OBJECTIVE: To evaluate the inhaler technique of patients and the awareness acquired during pulmonary teachings given in the beginning of the treatment. METHODS: This cross-sectional study was conducted at Civil Hospital, Karachi, from December 2013 to July 2014, and comprised patients diagnosed with obstructive broncho-pulmonary diseases and who were using inhaler therapy. A questionnaire was designed to assess the technique by an inhaler technique checklist, which was pilot-tested and was filled after obtaining verbal consent...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812081/response-to-comments-on-the-editorial-on-national-guideline-and-ild-pak-registry
#3
Mosavir Ansarie
No abstract text is available yet for this article.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812080/comments-on-the-editorial-on-ild-published-in-the-september-2016-issue-of-jpma
#4
Ali Bin Sarwar Zubairi
No abstract text is available yet for this article.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812079/comment-on-rahsan-ozcan-et-al-j-pak-med-assoc-2016-66-893-895-why-verify-helicobacter-pylori-eradication
#5
Rinaldo Pellicano
No abstract text is available yet for this article.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812078/classification-of-non-insulin-glucose-lowering-drugs
#6
Sanjay Kalra
This article proposes a simple and pragmatic classification of non-insulin glucose lowering drugs, which makes the pharmacology of diabetes easy to understand. While it is based on predominant mechanism of action, it encourages a pathophysiology-based approach to choice of drugs and drug combinations/permutations.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812077/preconception-management-of-endocrine-disorders
#7
Bharti Kalra, Yashdeep Gupta, Sanjay Kalra
Endocrine function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal endocrine function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. This review describes aspects of pre conception management related to various endocrine glands. Pre conception management of diabetes and thyroid will be covered in later articles.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812076/encapsulated-papillary-carcinoma-epc-of-breast-a-clinical-pathological-and-immunohistochemical-analysis-of-eight-cases
#8
Naima Tariq, Nadira Mamoon, Mariam Usman, Zafar Ali, Imran Nazir
Encapsulated papillary carcinoma (EPC) is a rare low grade carcinoma of the breast with excellent prognosis. This case series focuses on its histopathological and clinical characteristics in our material. Cases of papillary lesions of breast from 1st January 2012 to 30th December 2014 were retrieved from the hospital database. A total of 8 cases were categorized as EPC. Mean age of patients was 66 years. Breast lump with tumour size ranged from 1.5 to 5.0cm, and was the presentation in 75% of cases. Histopathology showed a well circumscribed lesion within a dilated duct comprising of fibro vascular cores lined by neoplastic cells, surrounded by thick fibrous capsule...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812075/can-a-diabetic-foot-be-malignant
#9
Muhammad Shoaib Zaidi, Asim Hassan, Samir Ouizi
Diabetes has been linked with malignancies like colon, rectum, liver, biliary tract, pancreas, kidney, leukaemia and melanoma. Melanoma can sometimes manifest as a diabetic foot ulcer.We describe an elderly male with Type 2 diabetes, who had presented to us with a non-healing wound at the right heel, that later turned out to be an invasive malignant melanoma.
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812074/cytomegalovirus-pneumonia-and-pulmonary-haemorrhage-in-a-patient-with-polyarteritis-nodosa
#10
Aysel Sunnetcioglu, Mahmut Sunnetcioglu, Habib Emre, Lokman Soyoral, Ugur Goktas
Cytomegaloviruses are opportunistic pathogens that cause lung infection in immunocompromised individuals. A 24-year-old male was admitted to the hospital with complaints of cough, fever and dyspnoea. He was receiving immunosuppressive therapy for polyarteritis nodosa. A chest X-ray showed heterogeneous right-sided opacity in the middle and lower lung zones. The diagnosis of cytomegalovirus pneumonia was confirmed by positive testfor serum cytomegalovirus IgM antibodies.Oneday after admission, haemoptysis developed and patient with hemoptysis who had shortness of breath was intubated...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812073/eosinophilic-granulomatosis-with-polyangiitis-presenting-with-multiple-intracerebral-haemorrhages-a-case-report
#11
Zafar Ullah, Zain Ul Abideen, Raja Farhat Shoaib, Arsalan Ahmad, Qamar Zaman, Rashid Nazir
Eosinophilic granulomatosis with polyangiitis also known as Churgg-Strauss syndrome is a systemic multi system vasculitis. Neurological involvement is mostly in the form of peripheral nervous system disease. Central nervous system involvement is relatively uncommon with most cases being secondary to ischaemic infarctions. Intra cerebral haemorrhage is rare and is usually in the form of solitary haemorrhagic lesions. Multiple intra cerebral haemorrhages are exceptionally rare with only one case documented in medical literature...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812072/descriptive-epidemiology-of-karachi-road-traffic-crash-mortality-from-2007-to-2014
#12
Rashid Jooma, Masood Ali Shaikh
According to World Health Organization's estimate for Pakistan, there were 25,781 (95% CI: 20,979-30582) Road Traffic Collision (RTC) fatalities in year 2013. The Road Traffic Injury Research and Prevention Center, collects RTC data on injuries and fatalities from five major public and private hospitals' emergency departments in Karachi. For the eight-year period, from 2007-2014, 9129 fatalities were recorded. Males accounted for 8008 (87.7%) all RTC fatalities. Highest number of fatalities were recorded in the 21-25 age group with 1329 (15...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812071/physical-therapy-as-a-profession-and-its-educational-development-in-pakistan
#13
Aamir Raoof Memon, Nasir Mansoor Sahibzada, Muhammad Ehab Azim, Furqan Ahmed Siddiqui
Physical therapists work in different medical and related settings and serve to maintain and restore functional capability. Pakistan has a disability rate of 2.65% with a total of around 5.035 million disabled people. Physical therapy as a profession started in 1956 at the Jinnah Postgraduate Medical Centre with a 2-year diploma, later on 4 years bachelors programme was also started. In 2008, doctor of physical therapy programme was initiated. The representative body "Pakistan Physical Therapy Association" was also established in 2008 which then joined the World Confederation for Physical Therapy in 2011...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812070/the-global-polio-eradication-initiative-gpei-in-pakistan
#14
Nighat Jahan Nadeem
The Global Polio Eradication Initiative (GPEI) has significantly reduced the worldwide incidence of poliomyelitis. However, polio remains endemic in Pakistan which poses a threat to the success of the GPEI. Issues faced by Pakistan relate to politics, terrorism, war, natural disasters, funding constraints, misconceptions and inadequate infrastructure. These contribute in hampering the aims of the GPEI and allow the deadly poliovirus to maintain its reservoir in Pakistan. Until polio is completely eradicated, all countries remain at risk of its re-emergence and this is of grave concern as potentially it could reverse the polio-free certified status of a whole World Health Organisation (WHO) region...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812069/frequency-of-different-types-of-gastric-varices-in-patients-with-cirrhosis-due-to-chronic-hepatitis-c
#15
Zamir Butt, Syed Muhammad Ali Shah, Muhammad Afzal, Irfan Younis, Muhammad Waqas, Hamna Atta
OBJECTIVE: To determine the frequency of different types of gastric varices in patients with hepatitis C virus-related cirrhosis. METHODS: The observational cross-sectional study was conducted from August 2014 to August 2015 at Aziz Bhatti Shaheed Teaching Hospital, Gujrat, Pakistan, using non-probability consecutive sampling. Patients having liver cirrhosis only due to chronic hepatitis C virus, portal vein diameter >12mm or spleen size >12cm in long axis and ascites with no previous history of variceal banding were included...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812068/dupatta-long-scarf-related-injuries-in-female-pillion-riders-in-karachi-pakistan
#16
Muhammad Saeed Minhas, Muhammad Muzzammil Sangani, Kashif Mehmood, Anissudin Bhatti, Ayesha Mughal, Ranjeet Kumar
OBJECTIVE: To assess the frequency, type of injuries and reason behind avoidable injuries due to dupatta entrapment in motorcycle wheels among female pillion riders. METHODS: This observational / descriptive study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from July 2013 to December 2014, and comprised female patients with dupatta-related motorbike injuries. The patients had injuries around head and neck, face, chest, abdomen, etc. SPSS 11 was used for data analysis...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812067/knowledge-regarding-calcium-contained-in-food-amongst-secondary-school-going-adolescents-in-karachi
#17
Sanam Shah, Niloufer Sultan Ali, Kashmira Nanji
OBJECTIVE: To determine the knowledge regarding calcium contained in food among secondary school-going children. METHODS: The cross-sectional study was conducted from February to May 2013 in two public and two private schools of Jamshed Town, Karachi. Stratified random sampling was used to raise the study sample. A pre-coded, piloted questionnaire was used for data collection. Data was analysed using SPSS 19. RESULTS: Of the 153 participants, 27(18...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812066/life-stress-and-somatic-symptoms-among-adolescents-gender-as-moderator
#18
Tasnim Rehna, Rubina Hanif, Sana Zahra Ali
OBJECTIVE: To study the impact of life stress on somatic symptoms of adolescents and to explore the moderating role of gender. METHODS: This cross-sectional study was conducted from September to December 2014 at secondary schools located in Islamabad, Pakistan. Data was collected by administering self-reported measures on a sample of adolescents including both males and females. SPSS 21 was used for data analysis. RESULTS: Of the 663 participants, 228(34...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812065/effect-of-administration-of-glucose-on-body-length-and-body-weight-of-the-chick-embryos
#19
Ruqqiq Shafi Minhas, Muhammad Yunus Khan
Objective: To assess the effect of glucose on body length and body weight of chick embryos. Methods: This experimental study was carried out at the College of Physicians and Surgeons Pakistan, Islamabad, from January 2013 to January 2014, and comprised chicken eggs. Fertilised eggs of Egyptian Fayyumi breed were injected with glucose (5% weight/volume solution) into egg albumen. The eggs were put in the incubator under standard conditions of temperature and humidity...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812064/pre-and-post-apheresis-platelet-cd-markers-evaluation-using-flow-cytometry
#20
Saleh Abdullah, Qamar Ayub, Muhammad Saboor
OBJECTIVE: To evaluate the effect of apheresis procedure on platelet's activation dependent glycoproteins' expression on their surface. METHODS: This study was conducted between June 2012 and June 2014, and comprised blood and platelet samples. Two samples were collected i.e. venous blood sample and apheresed platelet sample from the same donor. Platelet cluster of differentiation markers (41, 61, 62p and 63) were analysed within 2 hours of sample collection using flow cytometry...
November 2016: JPMA. the Journal of the Pakistan Medical Association
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