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Molecular and Cellular Endocrinology

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https://www.readbyqxmd.com/read/29680290/estrogen-receptor-beta-signaling-inhibits-pdgf-induced-human-airway-smooth-muscle-proliferation
#1
Nilesh Sudhakar Ambhore, Rathnavali Katragadda, Rama Satyanarayana Raju Kalidhindi, Michael A Thompson, Christina M Pabelick, Y S Prakash, Sathish Venkatachalem
Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of considerable interest, given epidemiological data showing more asthma in pre-menopausal women and aging men. Our previous studies demonstrated that estrogen receptor (ER) expression increases in asthmatic human ASM; however, very limited data are available regarding differential roles of ERα vs. ERβ isoforms in human ASM cell proliferation. In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved...
April 19, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29655603/new-technologies-to-uncover-the-molecular-basis-of-disorders-of-sex-development
#2
REVIEW
Hayk Barseghyan, Emmanuèle C Délot, Eric Vilain
The elegant developmental biology experiments conducted in the 1940s by French physiologist Alfred Jost demonstrated that the sexual phenotype of a mammalian embryo depended whether the embryonic gonad develops into a testis or not. In humans, anomalies in the processes that regulate development of chromosomal, gonadal or anatomic sex result in a spectrum of conditions termed Disorders/Differences of Sex Development (DSD). Each of these conditions is rare, and understanding of their genetic etiology is still incomplete...
April 12, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29655602/overexpression-of-ctrp3-protects-against-sepsis-induced-myocardial-dysfunction-in-mice
#3
Wen-Ying Wei, Zhen-Guo Ma, Ning Zhang, Si-Chi Xu, Yu-Pei Yuan, Xiao-Feng Zeng, Qi-Zhu Tang
C1q/tumor necrosis factor-related protein-3 (CTRP3) shows striking homologies of genomic structure to the adiponectin. In this study, we aimed to investigate the protective role of CTRP3 against sepsis-induced cardiomyopathy. Here, we overexpressed CTRP3 in myocardium by direct intramyocardial injection and constructed a model of lipopolysaccharide (LPS)-induced sepsis in mice. Our results demonstrated that cardiac-specific overexpression of CTRP3 remarkably attenuated myocardial dysfunction and increased the phosphorylation level of AMPKα during LPS-induced sepsis...
April 12, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29635012/a-brief-history-of-sex-determination
#4
REVIEW
Isabelle Stévant, Marilena D Papaioannou, Serge Nef
A fundamental biological question that has puzzled, but also fascinated mankind since antiquity is the one pertaining to the differences between sexes. Ancient cultures and mythologies poetically intended to explain the origin of the two sexes; philosophy offered insightful albeit occasionally paradoxical perceptions about men and women; and society as a whole put forward numerous intuitive observations about the traits that distinguish the two sexes. However, it was only through meticulous scientific research that began in the 16th century, and gradual technical improvements that followed over the next centuries, that the study of sex determination bore fruit...
April 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29627317/intestinal-cart-is-a-regulator-of-gip-and-glp-1-secretion-and-expression
#5
L Shcherbina, A Lindqvist, A-H Thorén Fischer, E Ahlqvist, E Zhang, S E Falkmer, E Renström, J Koffert, H Honka, N Wierup
Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression. CART expression was found in glucose-dependent insulinotropic polypeptide (GIP)-producing K-cells and glucagon-like peptide-1 (GLP-1)-producing L-cells in human duodenum and jejunum and CART levels were increased 60 min after a meal in humans...
April 5, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29614340/maternal-lipopolysaccharide-exposure-results-in-glucose-metabolism-disorders-and-sex-hormone-imbalance-in-male-offspring
#6
Mei Zhao, Li Yuan, Man-Man Yuan, Li-Li Huang, Chang Su, Yuan-Hua Chen, Yu-Ying Yang, Yan Hu, De-Xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29614339/key-gene-co-expression-modules-and-functional-pathways-involved-in-the-pathogenesis-of-graves-disease
#7
Xiaoqing Shao, Bin Wang, Kaida Mu, Ling Li, Qian Li, Weiwei He, Qiuming Yao, Xi Jia, Jin-An Zhang
Graves' disease (GD) is a common autoimmune thyroid disease characterized by positive thyroid stimulating hormone receptor antibody. To better understand its molecular pathogenesis, we adopted the weighted gene co-expression network analysis to reveal co-expression modules of key genes involved in the pathogenesis of GD, protein-protein interaction network analysis to identify the hub genes related to GD development and functional analyses to explore their possible functions. Our results showed that 1) a total of 2667 differentially expressed genes in our microarray study and 16 different gene co-expression modules were associated with GD, and 2) the most significant module was associated with the percentage of macrophages, T follicular helper cells and CD4+ memory T cells and mainly enriched in immune regulation and immune response...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29605460/impairment-of-learning-and-memory-performances-induced-by-bpa-evidences-from-the-literature-of-a-moa-mediated-through-an-ed
#8
REVIEW
Sakina Mhaouty-Kodja, Luc P Belzunces, Marie-Chantal Canivenc, Henri Schroeder, Cécile Chevrier, Elodie Pasquier
Many rodent studies and a few non-human primate data report impairments of spatial and non-spatial memory induced by exposure to bisphenol A (BPA), which are associated with neural modifications, particularly in processes involved in synaptic plasticity. BPA-induced alterations involve disruption of the estrogenic pathway as established by reversal of BPA-induced effects with estrogenic receptor antagonist or by interference of BPA with administered estradiol in ovariectomised animals. Sex differences in hormonal impregnation during critical periods of development and their influence on maturation of learning and memory processes may explain the sexual dimorphism observed in BPA-induced effects in some studies...
March 29, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29604329/mir-451a-attenuates-free-fatty-acids-mediated-hepatocyte-steatosis-by-targeting-the-thyroid-hormone-responsive-spot-14-gene
#9
Ni Zeng, Rong Huang, Nan Li, Hongmei Jiang, Ruobi Li, Fei Wang, Wen Chen, Min Xia, Qing Wang
The thyroid hormone responsive spot 14 (THRSP) gene is a de novo lipogenesis-related gene that plays a significant role in the initiation and development of nonalcoholic fatty liver disease (NAFLD). Several previous studies had shown that endogenous and environmental factors could regulate the expression of THRSP. The role of microRNAs (miRNAs), however, in controlling THRSP expression has not been investigated. In this study, we first constructed the hepatic steatosis cell model by using a mixture of free fatty acids (FFAs; oleate/palmitate, 2:1 ratio) to treat and demonstrate the promotive role of THRSP in lipid accumulation in hepatic cells...
March 28, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29596969/global-gene-expression-analysis-indicates-that-small-luteal-cells-are-involved-in-extracellular-matrix-modulation-and-immune-cell-recruitment-in-the-bovine-corpus-luteum
#10
Vijay Simha Baddela, Dirk Koczan, Torsten Viergutz, Andreas Vernunft, Jens Vanselow
Genome wide mRNA expression analysis of small and large luteal cells, isolated from the mature staged corpora lutea (CL), was not performed in any species. In the current study, we have isolated bovine small and large luteal cells from mid-cycle (day 10-11) animals and characterized their transcriptomes using "GeneChip™ Bovine Gene 1.0 ST Arrays". A total of 1276 genes were identified to be differentially expressed between small and large luteal cells. Data evaluation revealed that novel functions, extracellular matrix synthesis and immune cell recruitment, were enriched in small luteal cells...
March 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29596968/sequential-gene-regulatory-events-leading-to-glucocorticoid-evoked-apoptosis-of-cem-human-leukemic-cells-interactions-of-mapk-myc-and-glucocorticoid-pathways
#11
REVIEW
M S Webb, A L Miller, T L Howard, B H Johnson, S Chumakov, Y Fofanov, T Nguyen-Vu, C Y Lin, E B Thompson
Gene expression responses to glucocorticoid (GC) in the hours preceding onset of apoptosis was compared in three clones of human acute lymphoblastic leukemia CEM cells. Between 2 and 20 h, all three clones showed increasing numbers of responding genes. Each clone had many unique responses, but the two responsive clones showed a group of responding genes in common, different from the resistant clone. MYC levels and the balance of activities between the three major groups of MAPKs are known important regulators of glucocorticoid-driven apoptosis in several lymphoid cell systems...
March 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29596967/parabens-and-their-effects-on-the-endocrine-system
#12
REVIEW
Karolina Nowak, Wioletta Ratajczak-Wrona, Maria Górska, Ewa Jabłońska
Preservatives (ingredients which inhibit growth of microorganisms) are used to prolong shelf life of various foods, cosmetics, and pharmaceutical products. Parabens are one of the most popular preservatives used in the aforementioned products and is currently being used worldwide. Parabens are easily absorbed by the human body. Thus, it is important to discuss about their safety with respect to human physiology. In view of the current literature, which classifies parabens as a group of endocrine disrupting chemicals (EDCs), it seems that the precise assessment of their influence on the human endocrine system is particularly important...
March 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29580824/esr2-regulates-granulosa-cell-genes-essential-for-follicle-maturation-and-ovulation
#13
Vincentaben Khristi, V Praveen Chakravarthi, Prabhakar Singh, Subhra Ghosh, Archit Pramanik, Anamika Ratri, Shaon Borosha, Katherine F Roby, Michael W Wolfe, M A Karim Rumi
Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation. Ovulation failure occurred in two distinct rat models, a null mutant and a DNA binding domain (DBD) mutant of ESR2, indicating that transcriptional regulation by ESR2 is indispensable for ovulation. To define the regulatory role of ESR2 in preovulatory follicular maturation and ovulation, we investigated ovarian responsiveness to exogenous gonadotropins in prepubertal females...
March 23, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29580823/gw0742-ppar-beta-agonist-attenuates-hepatic-endoplasmic-reticulum-stress-by-improving-hepatic-energy-metabolism-in-high-fat-diet-fed-mice
#14
Flavia Maria Silva-Veiga, Tamiris Lima Rachid, Letícia de Oliveira, Francielle Graus-Nunes, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Endoplasmic reticulum (ER) stress and hepatic steatosis are intertwined with insulin resistance. PPARs are at the crossroads of these pathways. This study aimed to investigate the effects of GW0742 (PPAR-beta agonist) on hepatic energy metabolism and ER stress in a murine diet-induced obesity model. HF diet caused overweight, hyperinsulinemia, hepatic inflammation (increased NF-kB, TNF-alpha, and IL-6 protein expression) and favored hepatic lipogenesis, leading to ER stress, with ultrastructural and molecular alterations, ending up in proapoptotic stimulus...
March 23, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29577943/evidence-based-adverse-outcome-pathway-approach-for-the-identification-of-bpa-as-en-endocrine-disruptor-in-relation-to-its-effect-on-the-estrous-cycle
#15
REVIEW
Catherine Viguié, Sakina Mhaouty-Kodja, René Habert, Cécile Chevrier, Cécile Michel, Elodie Pasquier
Proper cyclicity is essential to reach successful optimal fertility. In rat and mice, BPA exposure is repeatedly and reliably reported to show an adverse effect on the estrous cycle after exposures at different life stages. In humans, a possible association between modifications of menstrual cycle characteristics (e.g. length of the cycle, duration of menstrual bleeding) and sub-fecundity or spontaneous abortion has been observed. Alterations of ovarian cyclicity can therefore be definitely considered as an adverse health outcome...
March 22, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29577942/emodin-protects-hyperglycemia-induced-injury-in-pc-12-cells-by-up-regulation-of-mir-9
#16
Lei Fan, Huifeng Zhang, Xiaobin Li, Guang Yang, Jingtao Ru, Tao Liu
BACKGROUND: Diabetic foot is a severe complication of diabetes mellitus, mainly caused by diabetic peripheral neuropathy. The objective of this study was to investigate the function of emodin (a neuroprotective agent reported previously) in diabetic peripheral neuropathy. METHODS: A neuron-like cell line PC-12 was subjected with high level glucose, before which emodin was applied to treat cells. The expression of miR-9 in cell was overexpressed or suppressed by miRNA transfection...
March 22, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29574003/cd105-maintains-the-thermogenic-program-of-beige-adipocytes-by-regulating-smad2-signaling
#17
Ryoko Higa, Toshikatsu Hanada, Hitoshi Teranishi, Daisuke Miki, Kazuyuki Seo, Kazumasa Hada, Hiroshi Shiraishi, Hiromitsu Mimata, Reiko Hanada, Kenji Kangawa, Toshiya Murai, Kazuwa Nakao
Beige adipocytes are thermogenic adipocytes with developmental and anatomical properties distinct from those of classical brown adipocytes. Recent studies have revealed several key molecular regulators of beige adipocyte development. CD105, also called endoglin, is a membrane protein composed of TGF-β receptor complex. It regulates TGF-β-family signal transduction and vascular formation in vivo. We report here that CD105 maintains the thermogenic gene program of beige adipocytes by regulating Smad2 signaling...
March 21, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29555596/aberrant-expression-of-the-sfrp-and-wif1-genes-in-invasive-non-functioning-pituitary-adenomas
#18
Wang Song, Liu Qian, Guo Jing, Feng Jie, Shan Xiaosong, Liu Chunhui, Li Yangfang, Li Guilin, Hua Gao, Zhang Yazhuo
Non-functioning pituitary adenomas (NFPAs) are the most common pituitary tumors and mainly invade the sphenoid, cavernous sinus or dura mate. Aberrant regulation of the Wnt signaling pathway plays an important role in tumorigenesis. This study was designed to investigate the relationships between secreted frizzled-related proteins (sFRPs), WIF1 genes and the invasion of NFPAs by tissue microassays (TMAs) of samples from 163 patients. Significantly weaker staining of WIF1 and sFRP4 were detected in the invasive group compared with the non-invasive group by TMAs (p = 0...
March 16, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29530783/protein-kinase-d1-conditional-null-mice-show-minimal-bone-loss-following-ovariectomy
#19
Wendy B Bollag, Ke-Hong Ding, Vivek Choudhary, Jianrui Xu, Qing Zhong, Ranya Elsayed, Lakiea J Bailey, Mohammed Elsalanty, Kanglun Yu, Maribeth H Johnson, Meghan E McGee-Lawrence, Carlos M Isales
We previously found that 3- and 6-month-old male mice with conditional ablation of protein kinase D1 (PRKD1) in osteoprogenitor cells (expressing Osterix) exhibited reduced bone mass. Others have demonstrated similar effects in young female PRKD1-deficient mice. Here we examined the bone resorptive response of adult female floxed control and conditional knockout (cKO) mice undergoing sham surgery or OVX. Femoral and tibial bone mineral density (BMD) values were significantly reduced upon OVX in control, but not cKO, females compared to the respective sham-operated mice...
March 9, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29524480/bisphenol-a-stimulates-differentiation-of-rat-stem-leydig-cells-in-vivo-and-in-vitro
#20
Lanlan Chen, Yu Zhao, Linchao Li, Lubin Xie, Xianwu Chen, Jianpeng Liu, Xiaoheng Li, Lixu Jin, Xingwang Li, Ren-Shan Ge
Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration model that mimics the pubertal development of Leydig cells and an in vitro stem Leydig cell differentiation model to examine the roles of BPA in Leydig cell development in rats. Intratesticular exposure to doses (100 and 1000 pmol/testis) of BPA from post-EDS day 14-28 stimulated Leydig cell developmental regeneration process by increasing serum testosterone level and Leydig cell-specific gene (Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1) and their protein expression levels...
March 7, 2018: Molecular and Cellular Endocrinology
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