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Journal of Neurochemistry

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https://www.readbyqxmd.com/read/28337771/5-ht7-receptor-shapes-spinogenesis-in-cortical-and-striatal-neurons-an-editorial-highlight-for-serotonin-5-ht7-receptor-increases-the-density-of-dendritic-spines-and-facilitates-synaptogenesis-in-forebrain-neurons
#1
EDITORIAL
Philippe Marin, Alexander Dityatev
Read the highlighted article 'Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons' on doi: 10.1111/jnc.13962.
March 24, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28332187/new-mechanisms-for-pain-from-neurons-to-glia-from-spinal-cord-to-cortex
#2
Min Zhuo
This is the Preface for the special article series "Pain".
March 22, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28326552/biogenesis-assembly-and-trafficking-of-acetylcholinesterase
#3
REVIEW
Richard L Rotundo
Acetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid-anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post-transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post-translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28326551/cyclic-imine-toxins-from-dinoflagellates-a-growing-family-of-potent-antagonists-of-the-nicotinic-acetylcholine-receptors
#4
REVIEW
Jordi Molgó, Pascale Marchot, Rómulo Aráoz, Evelyne Benoit, Bogdan I Iorga, Armen Zakarian, Palmer Taylor, Yves Bourne, Denis Servent
We present an overview of the toxicological profile of the fast-acting, lipophilic macrocyclic imine toxins, an emerging family of organic compounds associated with algal blooms, shellfish contamination and neurotoxicity. Worldwide, shellfish contamination incidents are expanding; therefore, the significance of these toxins for the shellfish food industry deserves further study. Emphasis is directed to the dinoflagellate species involved in their production, their chemical structures, and their specific mode of interaction with their principal natural molecular targets, the nicotinic acetylcholine receptors, or with the soluble acetylcholine-binding protein, used as a surrogate receptor model...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28326549/the-three-finger-toxin-fold-a-multifunctional-structural-scaffold-able-to-modulate-cholinergic-functions
#5
REVIEW
Pascal Kessler, Pascale Marchot, Marcela Silva, Denis Servent
Three-finger fold toxins are miniproteins frequently found in Elapidae snake venoms. This fold is characterized by three distinct loops rich in β-strands and emerging from a dense, globular core reticulated by four highly conserved disulfide bridges. The number and diversity of receptors, channels, and enzymes identified as targets of three-finger fold toxins is increasing continuously. Such manifold diversity highlights the specific adaptability of this fold for generating pleiotropic functions. Although this toxin superfamily disturbs many biological functions by interacting with a large diversity of molecular targets, the most significant target is the cholinergic system...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28326544/personalized-genetics-of-the-cholinergic-blockade-of-neuroinflammation
#6
REVIEW
Alon Simchovitz, Michael T Heneka, Hermona Soreq
Acetylcholine signaling is essential for cognitive functioning and blocks inflammation. To maintain homeostasis, cholinergic signaling is subjected to multi-leveled and bidirectional regulation by both proteins and non-coding microRNAs ('CholinomiRs'). CholinomiRs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (AChE). Notably, AChE inhibitors are the only currently approved line of treatment for Alzheimer's disease patients...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28326543/animal-models-for-studying-motor-axon-terminal-paralysis-and-recovery
#7
REVIEW
Michela Rigoni, Cesare Montecucco
An extraordinary property of the peripheral nervous system is that nerve terminals can regenerate after damage caused by different physical, chemical, or biological pathogens. Regeneration is the result of a complex and ill-known interplay among the nerve, the glia, the muscle, the basal lamina and, in some cases, the immune system. This phenomenon has been studied using different injury models mainly in rodents, particularly in mice, where a lesion can be produced in a chosen anatomical area. These approaches differ significantly among them for the nature of the lesion and the final outcomes...
March 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28306143/mutant-eif2b-leads-to-impaired-mitochondrial-oxidative-phosphorylation-in-vanishing-white-matter-disease
#8
Gali Raini, Reut Sharet, Melisa Herrero, Andrea Atzmon, Anjana Shenoy, Tamar Geiger, Orna Elroy-Stein
Eukaryotic translation initiation factor 2B (eIF2B) is a master regulator of protein synthesis under normal and stress conditions. Mutations in any of the five genes encoding its subunits lead to Vanishing White Matter (VWM) disease, a recessive genetic deadly illness caused by progressive loss of white matter in the brain. In the current study we used fibroblasts, which are not involved in the disease, to demonstrate the involvement of eIF2B in mitochondrial function and abundance. Mass-spectrometry of total proteome of mouse embryonic fibroblasts (MEFs) isolated from Eif2b5(R132H/R132H) mice revealed unbalanced stoichiometry of proteins involved in oxidative phosphorylation and of mitochondrial translation machinery components, among others...
March 17, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28301040/dimercaprol-is-an-acrolein-scavenger-that-mitigates-acrolein-mediated-pc-12-cells-toxicity-and-reduces-acrolein-in-rat-following-spinal-cord-injury
#9
Ran Tian, Riyi Shi
Acrolein is one of the most toxic byproducts of lipid peroxidation, and it has been shown to be associated with multiple pathological processes in trauma and diseases, including spinal cord injury, multiple sclerosis, and Alzheimer's disease. Therefore, suppressing acrolein using acrolein scavengers has been suggested as a novel strategy of neuroprotection. In an effort to identify effective acrolein scavengers, we have confirmed that dimercaprol, which possesses thiol functional groups, could bind and trap acrolein...
March 16, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28299805/novel-ketone-body-therapy-for-managing-alzheimer-s-disease-an-editorial-highlight-for-effects-of-a-dietary-ketone-ester-on-hippocampal-glycolytic-and-tricarboxylic-acid-cycle-intermediates-and-amino-acids-in-a-3xtgad-mouse-model-of-alzheimer-s-disease
#10
EDITORIAL
Michelle A Puchowicz, Thomas N Seyfried
Read the highlighted article 'Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease' on doi: 10.1111/jnc.13958.
March 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28295333/calmodulin-kinases-essential-regulators-in-health-and-disease
#11
REVIEW
Sayaka Takemoto-Kimura, Kanzo Suzuki, Shin-Ichiro Horigane, Satoshi Kamijo, Masatoshi Inoue, Masayuki Sakamoto, Hajime Fujii, Haruhiko Bito
Neuronal activity induces intracellular Ca(2+) increase, which triggers activation of a series of Ca(2+) -dependent signalling cascades. Among these, the multifunctional Ca(2+) / calmodulin-dependent protein kinases (CaMKs, or calmodulin kinases) play key roles in neuronal transmission, synaptic plasticity, circuit development and cognition. The most investigated CaMKs for these roles in neuronal functions are CaMKI, CaMKII, CaMKIV and we will shed light on these neuronal CaMKs' functions in this review. Catalytically active members of CaMKs currently are CaMKI, CaMKII, CaMKIV and CaMKK...
March 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28295323/crip1a-inhibits-endocytosis-of-g-protein-coupled-receptors-activated-by-endocannabinoids-and-glutamate-by-a-common-molecular-mechanism
#12
Fabrizio Mascia, Lisa Klotz, Judith Lerch, Mostafa A Ahmed, Yan Zhang, Ralf Enz
The excitability of the central nervous system depends largely on the surface density of neurotransmitter receptors. The endocannabinoid receptor CB1 R and the metabotropic glutamate receptor mGlu8 R are expressed presynaptically where they reduce glutamate release into the synaptic cleft. Recently, the CB1 R interacting protein CRIP1a was identified and characterized to regulate CB1 R activity in neurons. However, underlying molecular mechanisms are largely unknown. Here, we identified a common mechanism used by CRIP1a to regulate the cell surface density of two different types of G-protein coupled receptors, CB1 R and mGlu8a R...
March 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28294337/copper-increases-the-ability-of-6-hydroxydopamine-to-generate-oxidative-stress-and-the-ability-of-ascorbate-and-glutathione-to-potentiate-this-effect-potential-implications-in-parkinson-s-disease
#13
Antón Cruces-Sande, Estefanía Méndez-Álvarez, Ramón Soto-Otero
Copper is an essential metal for the function of many proteins related to important cellular reactions and also involved in the synaptic transmission. Although there are several mechanisms involved in copper homeostasis, a dysregulation in this process can result in serious neurological consequences, including degeneration of dopaminergic neurons. 6-Hydroxydopamine is a dopaminergic neurotoxin mainly used in experimental models of Parkinson's disease, whose neurotoxicity has been related to its ability to generate free radicals...
March 14, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28294336/adenosine-production-by-brain-cells
#14
Edwin K Jackson, Shawn E Kotermanski, Elizabeth V Menshikova, Raghvendra K Dubey, Travis C Jackson, Patrick M Kochanek
The early release of adenosine following traumatic brain injury (TBI) suppresses seizures and brain inflammation; thus, it is important to elucidate the cellular sources of adenosine following injurious stimuli triggered by TBI so that therapeutics for enhancing the early adenosine-release response can be optimized. Using mass spectrometry with (13) C-labelled standards, we investigated in cultured rat neurons, astrocytes, and microglia the effects of oxygen-glucose deprivation (OGD; models energy failure), H2 O2 (produces oxidative stress), and glutamate (induces excitotoxicity) on intracellular and extracellular levels of 5'-AMP (adenosine precursor), adenosine, and inosine and hypoxanthine (adenosine metabolites)...
March 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28295320/brefeldin-a-sensitive-mechanisms-contribute-to-endocytotic-membrane-retrieval-and-vesicle-recycling-in-cerebellar-granule-cells
#15
Alberto Rampérez, José Sánchez-Prieto, Magdalena Torres
The recycling of synaptic vesicle (SV) proteins and transmitter release both occur at multiple sites along the axon. These processes are sensitive to inhibition of the small GTP binding protein ARF1, which regulates the AP-1/AP-3 complex. As the axon matures, SV recycling becomes restricted to the presynaptic bouton, and its machinery undergoes a complex process of maturation. We used the styryl dye FM1-43 to highlight differences in the efficiency of membrane recycling at different sites in cerebellar granule cells cultured for 7 days in vitro...
March 11, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28295345/the-viral-protein-gp120-decreases-the-acetylation-of-neuronal-tubulin-potential-mechanism-of-neurotoxicity
#16
Valeria Avdoshina, Seamus P Caragher, Erin D Wenzel, Francesca Taraballi, Italo Mocchetti, G Jean Harry
The human immunodeficiency virus (HIV) envelope protein gp120 promotes axonal damage and neurite pruning, similar to that observed in HIV positive subjects with neurocognitive disorders. Thus, gp120 has been used to examine molecular and cellular pathways underlying HIV-mediated neuronal dysfunction. Gp120 binds to tubulin beta III, a component of neuronal microtubules. Microtubule function, which modulates the homeostasis of neurons, is regulated by polymerization and post-translational modifications. Based on these considerations, we tested the hypothesis that gp120 induces dynamic instability of neuronal microtubules...
March 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28294334/comparative-assessment-of-6-18-f-fluoro-l-m-tyrosine-and-6-18-f-fluoro-l-dopa-to-evaluate-dopaminergic-presynaptic-integrity-in-a-parkinson-s-disease-rat-model
#17
REVIEW
Guillaume Becker, Bahri Mohamed Ali, Anne Michel, Fabian Hustadt, Gaëtan Garraux, André Luxen, Christian Lemaire, Alain Plenevaux
Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson's disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [(18) F]fluoro-3,4-dihydroxyphenyl-L-alanine ([(18) F]FDOPA) and 6-[(18) F]fluoro-L-m-tyrosine ([(18) F]FMT)...
March 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28278364/methyl-cpg-level-at-distal-part-of-heat-shock-protein-promoter-hsp70-exhibits-epigenetic-memory-for-heat-stress-by-modulating-recruitment-of-pou2f1-associated-nucleosome-remodeling-deacetylase-nurd-complex
#18
Tatiana Kisliouk, Tomer Cramer, Noam Meiri
Depending on its stringency, exposure to heat in early life leads to either resilience or vulnerability to heat stress later in life. We hypothesized that epigenetic alterations in genes belonging to the cell proteostasis pathways are attributed to long-term responses to heat stress. Epigenetic regulation of the mRNA expression of the molecular chaperone heat-shock protein (HSP) 70 (HSPA2) was evaluated in the chick hypothalamus during the critical period of thermal-control establishment on day 3 posthatch and during heat challenge on day 10...
March 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28278355/functional-and-structural-plasticity-in-the-primary-somatosensory-cortex-associated-with-chronic-pain
#19
REVIEW
Woojin Kim, Sun Kwang Kim, Junichi Nabekura
Tissue or nerve injury induces widespread plastic changes from the periphery and spinal cord up to the cortex, resulting in chronic pain. Although many clinicians and researchers have extensively studied altered nociceptive signaling and neural circuit plasticity at the spinal cord level, effective treatments to ameliorate chronic pain are still insufficient. For about the last two decades, the rapid development in macroscopic brain imaging studies on humans and animal models have revealed maladaptive plastic changes in the 'pain matrix' brain regions, which may subsequently contribute to chronic pain...
March 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28267200/microtubule-dynamics-and-the-neurodegenerative-triad-of-alzheimer-s-disease-the-hidden-connection
#20
REVIEW
Roland Brandt, Lidia Bakota
Alzheimer's disease (AD) is the most common neurodegenerative disorder and is, on a histopathological level, characterized by the presence of extracellular amyloid plaques composed of the protein fragment Aβ, and intracellular neurofibrillary tangles (NFTs), which contain the microtubule-associated protein tau in a hyperphosphorylated state. In AD defects in microtubule (MT) assembly and organization have also been reported; however, it is unclear whether MT abnormalities have a causal and early role in the disease process or represent a common end point downstream of the neurodegenerative cascade...
March 7, 2017: Journal of Neurochemistry
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