journal
MENU ▼
Read by QxMD icon Read
search

Advances in Clinical Chemistry

journal
https://www.readbyqxmd.com/read/29655464/preface
#1
EDITORIAL
Gregory S Makowski
No abstract text is available yet for this article.
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655463/proteomics-for-biomarker-identification-and-clinical-application-in-kidney-disease
#2
Lin Chen, Wei Su, Hua Chen, Dan-Qian Chen, Ming Wang, Yan Guo, Ying-Yong Zhao
Treatment effectiveness for kidney disease is limited by lack of accuracy, sensitivity, specificity of diagnostic, prognostic, and therapeutic biomarkers. The gold standard test renal biopsy along with serum creatinine and proteinuria is often necessary to establish a diagnosis, particularly in glomerular disease. Proteomics has become a powerful tool for novel biomarker discovery in kidney disease. Novel proteomics offer earlier and more accurate diagnosis of renal pathology than possible with traditional biomarkers such as serum creatinine and urine protein...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#3
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655461/metabolomics-and-lipidomics-of-ischemic-stroke
#4
Anthony Au
Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics and lipidomics are modern disciplines that characterize the metabolites and lipid components of a biological system, respectively. Because the pathogenesis of ischemic stroke is heterogeneous and multifactorial, it is crucial to establish comprehensive metabolomic and lipidomic approaches to elucidate these alterations in this disease...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655460/uncertainty-in-measurement-procedures-for-determining-uncertainty-with-application-to-clinical-laboratory-calculations
#5
Robert B Frenkel, Ian Farrance
In Part II of this review we consider the very common case of multiple inputs to a measurement process. We derive, using only elementary steps and the basic mathematics covered in Part I, the formula for the propagation of uncertainties from the inputs to the output. The Gaussian density distribution is briefly explained, since an understanding of this distribution is needed for the determination of so-called expanded uncertainties at the end of a measurement process. The propagation formula in general involves correlations among the inputs, although in many cases these correlations can be considered negligible...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655459/adiponectin-and-its-isoforms-in-pathophysiology
#6
Merel van Andel, Annemieke C Heijboer, Madeleine L Drent
Adiponectin circulates in blood in multiple isoforms. High molecular weight (HMW) adiponectin is thought to be most biologically active and promotes glucose uptake, insulin sensitivity, and fatty acid oxidation. In obesity, adiponectin isoform formation is disrupted, leading to an inverse association between metabolic disease and HMW and total adiponectin. Adiponectin isoforms also function as acute-phase reactants influencing inflammation in acute and chronic disease. Interestingly, adiponectin and mortality have a U-shaped association...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29655458/standardization-of-bnp-and-nt-probnp-immunoassays-in-light-of-the-diverse-and-complex-nature-of-circulating-bnp-related-peptides
#7
Alexander G Semenov, Evgeniya E Feygina
Brain natriuretic peptide (BNP) and the N-terminal fragment of the BNP precursor (NT-proBNP) are widely used as heart failure (HF) biomarkers. Since the discovery of BNP in 1988, much effort has been allocated to the precise detection of BNP and NT-proBNP levels for reliable HF diagnostics. As a result, measurements of these biomarkers are globally accepted and used in clinical practice for the diagnosis of acute and chronic HF, risk stratification, and monitoring response to therapy. Several immunoassays specific for BNP and NT-proBNP are currently commercially available...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478518/preface
#8
EDITORIAL
Gregory S Makowski
No abstract text is available yet for this article.
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478517/metabolomics-of-major-depressive-disorder-and-bipolar-disorder-overview-and-future-perspective
#9
Kenji Hashimoto
Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their shared clinical features result in high rates of misdiagnosis due to a lack of biomarkers that allow their differentiation. BD is more frequently misdiagnosed as MDD because of overlapping symptomology, often later onset of mania, and frequent occurrence of depressive episodes in patients with BD. Misdiagnosis is also increased when patients with BD present symptoms indicative of a clinically significant depressive episode, but are premorbid for manic symptoms, or previous manic states not recognized...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478516/inflammatory-response-during-myocardial-infarction
#10
Joaquim B Oliveira, Alexandre A S M Soares, Andrei C Sposito
The occlusion of a coronary artery by a thrombus generated on a ruptured atherosclerotic plaque has been pursued in the last decades as a determining event for the clinical outcome after myocardial infarction (MI). Yet, MI causes a cell death wave front, which triggers an inflammatory response to clear cellular debris, and which in excess can double the myocardial lesion and influence the clinical prognosis in the short and long term. Accordingly, proper, timely regulated inflammatory response has now been considered a second pivotal player in cardiac recovery after MI justifying the search for pharmacological strategies to modulate inflammatory effectors...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478515/distribution-of-fatty-acids-and-lipids-during-pregnancy
#11
Preeti Chavan-Gautam, Alka Rani, Dilys J Freeman
Maternal fatty acid and lipid metabolism undergoes changes during pregnancy to facilitate fetal growth and development. Different types of fatty acids have different roles in maintaining a successful pregnancy and they are incorporated into different forms of lipids for the purpose of storage and transport. This chapter aims to provide an understanding of the distribution and metabolism of fatty acids and lipids in the maternal, placental, and fetal compartments. We further describe how this distribution is altered in maternal obesity, preterm birth, and pregnancy complications such as gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478514/uncertainty-in-measurement-procedures-for-determining-uncertainty-with-application-to-clinical-laboratory-calculations
#12
Robert B Frenkel, Ian Farrance
The "Guide to the Expression of Uncertainty in Measurement" (GUM) is the foundational document of metrology. Its recommendations apply to all areas of metrology including metrology associated with the biomedical sciences. When the output of a measurement process depends on the measurement of several inputs through a measurement equation or functional relationship, the propagation of uncertainties in the inputs to the uncertainty in the output demands a level of understanding of the differential calculus...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478513/blood-glucose-determination-effect-of-tube-additives
#13
Giuseppe Lippi, Mads Nybo, Janne Cadamuro, Joao T Guimaraes, Edmée van Dongen-Lases, Ana-Maria Simundic
The measurement of fasting plasma glucose may be biased by a time-dependent decrease of glucose in blood tubes, mainly attributable to blood cell metabolism when glycolysis is not rapidly inhibited or blood cells cannot be rapidly separated from plasma. Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29478512/protein-carbamylation-chemistry-pathophysiological-involvement-and-biomarkers
#14
Stéphane Jaisson, Christine Pietrement, Philippe Gillery
Protein carbamylation refers to a nonenzymatic modification, which consists in the binding of isocyanic acid on protein functional groups. This reaction is responsible for the alteration in structural and functional properties of proteins, which participate in their molecular aging. Protein molecular aging is now considered a molecular substratum for the development of chronic and inflammatory diseases, including atherosclerosis, chronic kidney disease, or rheumatoid arthritis. As a consequence, carbamylation-derived products have been proposed as interesting biomarkers in various pathological contexts and appropriate analytical methods have been developed for their quantification in biological fluids...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304905/preface
#15
EDITORIAL
Gregory S Makowski
No abstract text is available yet for this article.
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304904/liquid-biopsy-from-basic-research-to-clinical-practice
#16
Mónica Macías, Estibaliz Alegre, Angel Díaz-Lagares, Ana Patiño, Jose L Pérez-Gracia, Miguel Sanmamed, Rafael López-López, Nerea Varo, Alvaro González
Liquid biopsy refers to the molecular analysis in biological fluids of nucleic acids, subcellular structures, especially exosomes, and, in the context of cancer, circulating tumor cells. In the last 10 years, there has been an intensive research in liquid biopsy to achieve a less invasive and more precise personalized medicine. Molecular assessment of these circulating biomarkers can complement or even surrogate tissue biopsy. Because of this research, liquid biopsy has been introduced in clinical practice, especially in oncology, prenatal screening, and transplantation...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304903/locked-nucleic-acid-technology-for-highly-sensitive-detection-of-somatic-mutations-in-cancer
#17
Takayuki Ishige, Sakae Itoga, Kazuyuki Matsushita
The molecular diagnosis of the cancer mutational status is essential for modern clinical laboratory medicine. Mutations in EGFR, KRAS, BRAF, and PIK3CA genes are widely analyzed in solid tumors such as lung cancer, colorectal cancer, breast cancer, and melanoma. The allele-specific polymerase chain reaction, high-resolution melting, and Sanger sequencing are used for detecting and identifying gene mutations in many clinical laboratories. The locked nucleic acid (LNA) is a class of nucleic acid analogs that contain a methylene bridge connecting the 2' oxygen and 4' carbon in the ribose moiety...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304902/laboratory-assessment-of-anemia
#18
Sirisha Kundrapu, Jaime Noguez
Anemia is one of the most common health problems in both industrialized and developing countries. It has been recognized by the World Health Organization as an important disorder leading to significant health care burden. Laboratory testing plays a significant role in the diagnosis of most types of anemia since the clinical diagnosis may not always be straightforward, especially with multiple underlying conditions. Once the existence of anemia is established, the cause must be determined to enable selection of a specific and effective therapy...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304901/indoor-tanning-a-gianus-bifrons-vitamin-d-and-human-cancer
#19
Giuseppe Lippi, Gianfranco Cervellin, Elisa Danese
Despite it is now undeniable that indoor tanning exposure is associated with a number of skin cancers, its favorable effects on vitamin D status may bear some underestimated and currently unexplored health benefits. Vitamin D is a fat-soluble vitamin naturally present in a limited number of foods, the concentration of which largely depends on ultraviolet (UV) B sources exposure in humans. A strong, graded, and inverse association has been documented between serum vitamin D and the risk of developing certain types of malignancy, especially colorectal, breast, lung, bladder, and kidney cancers...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304900/circulating-tumor-cells-and-implications-of-the-epithelial-to-mesenchymal-transition
#20
Lori E Lowes, Alison L Allan
The majority of cancer-related deaths result from metastasis, the process by which cancer cells escape the primary tumor site and enter into the blood circulation in order to disseminate to secondary locations throughout the body. Tumor cells found within the circulation are referred to as circulating tumor cells (CTCs), and their detection and enumeration correlate with poor prognosis. The epithelial-to-mesenchymal transition (EMT) is a dynamic process that imparts epithelial cells with mesenchymal-like properties, thus facilitating tumor cell dissemination and contributing to metastasis...
2018: Advances in Clinical Chemistry
journal
journal
25561
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"