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Journal of Genetics

N Mokhtari, B E Sayed-Tabatabaei, M Bahar, H Arabnezhad
This experiment was conducted to assess genetic relationships among safflower genotypes from different geographical regions of Iran and other countries using newly developed simple sequence repeat (SSR) markers. By enrichment method, 32 primer pairs were designed of which 18 pairs were able to detect polymorphism in 105 safflower cultivars from Carthamus tinctorius , C. oxyacanthus , C. lanatus , C. glaucus , C. boissieri and C. dentatus . The selected SSR primers amplified a total of 59 alleles with an average of 3...
June 15, 2018: Journal of Genetics
Ling Wang, Hong Yu, Qi Li
Chlorostoma rustica is an ecologically and economically important species in China, which plays an important role on the overall function of the coastal systems. Understanding of the genetic structure of C. rustica populations is vital to breeding strategies and conservation programmes. In this study, we isolated and characterized 23 microsatellite loci with high polymorphism using the restriction site-associated DNA sequencing approach. The number of alleles per locus ranged from 6 to 18, and the expected heterozygosities varied from 0...
June 6, 2018: Journal of Genetics
Piyali Misra, Subramaniam Ganesh
No abstract text is available yet for this article.
June 2018: Journal of Genetics
Eva Šatović, Miroslav Plohl
In this study, characterization of DTHS3 satellite DNA (satDNA) was further expanded within the class Bivalvia. Monomer variants of DTHS3 satDNA were compared in 12 bivalve species belonging to two different subclasses, Heterodonta and Pteriomorphia. This satDNA, whose age is estimated to a minimum of 516 Ma, is contributing to the concept of the dual character of satDNA sequences: their sequence preservation throughout long evolutionary periods and generation of species-specific variants of the same satDNA family...
June 2018: Journal of Genetics
Vincenzo Buono, Giorgia Galliani, Emiliano Mancini, Francesca Davoli, Chiara Mengoni, Nadia Mucci, Leonardo Vignoli
Habitat loss and fragmentation are threatening amphibians by increasing population isolation. However, artificial waterbodies created for livestockmay contrast this phenomenon by providing surrogate habitats for amphibians. Here, we performed a genetic study on an amphibian species, Lissotriton vulgaris meridionalis , in a rural area in central Italy where natural wetlands are disappearing and drinking troughs for cattle watering are widespread. Specifically, we tested a panel of microsatellite markers to identify a suitable tool for addressing conservation genetic issues of this species that is undergoing severe local decline...
June 2018: Journal of Genetics
Peipei Wang, Cheng Zhao, Shuqiao Chen, Shaowu Yin, Qintao Wang, Zecheng Li, Guoqin Zhou
Microsatellite lociwere used for parentage identification of Odontobutis potamophlia in five full-sib families. The combined exclusion probability of the first (E-1P) and the second parent (E-2P) revealed an obvious increase with the increase of number of microsatellite loci. The combined exclusion probability based on allele frequency suggested that at least eight microsatellite loci were needed for the identification of the 150 individuals from five families supported by the genetic distance analysis of individuals of these families...
June 2018: Journal of Genetics
Andreas Syrimis, Nayia Nicolaou, Angelos Alexandrou, Ioannis Papaevripidou, Michael Nicolaou, Eleni Loukianou, Violetta Christophidou-Anastasiadou, Stavros Malas, Carolina Sismani, George A Tanteles
Aniridia is a rare congenital ocular malformation that follows an autosomal dominant mode of inheritance. Most patients carry pathogenic point mutations in the paired box 6 gene ( PAX6 ), but some carry deletions involving the 11p13 region, encompassing partly or completely PAX6 or the region downstream. We identified a novel deletion, ~564 kb in size located about 46.5 kb downstream of PAX6 in a family with bilateral aniridia and foveal hypoplasia using array-CGH and multiplex ligation-dependent probe amplification...
June 2018: Journal of Genetics
Fraser J Combe, Evelyn Taylor-Cox, Graeme Fox, Tommy Sandri, Nick Davis, Martin J Jones, Bradley Cain, David Mallon, W Edwin Harris
High-throughput sequencing tools promise to revolutionize many aspects of genetic research, e.g. by allowing the identification of functional adaptive genetic variation. However, the expense and expertise required to apply these tools to basic conservation questions is a challenge for applications outside academia, resulting in a so-called 'conservation genomics gap' (Shafer et al . 2015). The conservation genetics paradigm is that, basic information about inbreeding and gene flow are often critical to inform conservation management of small populations (Ouborg et al ...
June 2018: Journal of Genetics
Zhan-Ji Liu, Fei Li, Li-Guo Wang, Ren-Zhong Liu, Jun-Jun Ma, Ming-Chuan Fu
NAC genes, specific to plants, play important roles in plant development as well as in response to biotic and abiotic stresses. Here, a novel gene encoding a NAC domain, named as GhSNAC3 , was isolated from upland cotton ( Gossypium hirsutum L.). Sequence analyses showed that GhSNAC3 encodes a protein of 346 amino acids with an estimated molecular mass of 38.4 kDa and pI of 8.87. Transient localization assays in onion epidermal cells confirmed GhSNAC3 is a nuclear protein. Transactivation studies using a yeast system revealed that GhSNAC3 functions as a transcription activator...
June 2018: Journal of Genetics
Tajamul Hussain, Salman Alrokayan, Upadhyay Upasna, Manickam Pavithrakumari, Jaganathan Jayapriya, Vijay Kumar Kutala, Shaik Mohammad Naushad
Studies on the association of cytochrome p450 A1 (m1, m2), catechol-O-methyltransferase (COMT) H108L, glutathione S-transferase (GST) T1 and M1 polymorphisms with breast cancer risk were inconclusive. The current study was aimed to clarify the ambiguity in genetic associations of these enzymes with breast cancer risk on a global perspective. A systematic literature search was carried out in PubMed, Google Scholar and Medline, covering all the case-control studies published until September 2017. A meta-analysis was performed based on the random-effect and fixed-effect models to calculate the overall association of each genetic variant with breast cancer risk...
June 2018: Journal of Genetics
Mulugeta Seyoum, Xiong Ming Du, Shou Pu He, Yin Hua Jia, Zhaoe Pan, Jun Ling Sun
Improvement of cotton fibre yield and quality is challenging due to the narrow genetic base of modern cotton cultivars, which emphasizes the great need to effectively explore the existing germplasm resources. With major objective to assess the genetic diversity and population structure at DNA level, 302 elite upland cotton germplasm accessions (253 Chinese and 49 different exotic origins), were genotyped using 198 simple sequence repeats (SSRs) markers. Each of the 198 markers differed greatly in its ability to detect variations in the panel of cotton germplasm...
June 2018: Journal of Genetics
Pacint Moez, Reham Moftah, Hayam A Mahmoud
Sickle cell haemoglobinopathy is a genetic disorder caused by the presence of haemoglobin S (HbS) including sickle cell disease (SCD) (sickle cell anemia, HbS/β -thalassaemia and HbSC disease) and sickle cell trait. In Siwa Oasis, most remote oasis town in Egypt, the prevalence rate of sickle cell haemoglobinopathy is approaching 20%. The Xmn 1 polymorphism was reported to increase the HbF level ameliorating the severity of the SCD. The present study aims mainly to investigate the genotype frequency of -158Gγ (C→T) Xmn1 polymorphism in Siwa Oasis, Egypt and to study, if possible, any association with increased HbF expression...
June 2018: Journal of Genetics
Majid Pasandideh, Ghodrat Rahimi-Mianji, Mohsen Gholizadeh
Genomewide association study (GWAS) is an efficient tool for the detection of SNPs and candidate genes in quantitative traits. Growth rate is an important trait for increasing the meat production in sheep. A total of 96 Baluchi sheep were genotyped using Illumina Ovine SNP50 BeadChip to run a GWAS for an average daily gain (ADG) and Kleiber ratio (KR) traits in different periods of age in sheep. Traits included were average daily gain from birth to three months (ADG0-3 ), from three months to six months (ADG3-6 ), from six months to nine months (ADG6-9 ), from nine months to yearling (ADG9-12 ), from birth to six months (ADG0-6 ), from three months to nine months (ADG3-9 ), from three months to yearling (ADG3-12 ) and corresponding Kleiber ratios (KR0-3 , KR3-6 , KR6-9 , KR9-12 , KR0-6 , KR3-9 and KR3-12 , respectively)...
June 2018: Journal of Genetics
G R Gowane, Najif Akram, S S Misra, Ved Prakash, Arun Kumar
The objective of this study was to assess the genetic diversity of the Sirohi goat for DQB and DQB1 loci, and to study their association with antibody response induced by the Peste des petits ruminants (PPR) vaccine. A total of 360 Sirohi kids were studied using single stranded confirmation polymorphism (SSCP) followed by polymerase chain reaction sequence-based typing (PCR-SBT) for DQB and DQB1 diversities. The competitive enzyme-linked immuno-sorbent assay (C-ELISA) was used to evaluate immune response post-PPR vaccination...
June 2018: Journal of Genetics
Bujun Mei, Zhihua Wang
Genomewide association studies (GWASs) typically require a base of linkage disequilibrium (LD) to capture quantitative trait locus (QTL) signals. In this study, we tested whether identifying QTLs in the framework of GWAS can be based only on linkage information. Our study sought to validate a method to replace LD with linkage in association studies, and we investigated the statistical power of different heritabilities and the number of QTLs using simulation data. We found that it is entirely feasible to exploit the multiple regression method for GWASs using only linkage information...
June 2018: Journal of Genetics
Meijuan Li, Shili Li, Yu Rao, Sheng Cui, Kemian Gou
Smooth muscle myosin heavy chain (SM-MHC) is exclusively expresses in smooth muscle, which takes part in smooth muscle cell contraction. Here, we used an insertional mutation mouse whose heavy polypeptide 11 ( Myh11 ) gene has been disrupted and no SM-MHC protein has been detected. Compared to the wild-type and SM-MHC+/- mice, the SM-MHC-/- neonates had large round bellies, thin-walled giant bladders, and large stomachs with huge gas bubbles. Most of it died within 10 h and the rest within 20 h after birth...
June 2018: Journal of Genetics
Naisu Yang, Lin Mu, Bohao Zhao, Manman Wang, Shuaishuai Hu, Bin Zhao, Yang Chen, Xinsheng Wu
Solute carrier family 7 member 11 ( SLC7A11 ) is a cystine/glutamate exchanger, also known as xCT, has been found to play an important role in pheomelanin synthesis. Adjusting the cystine content of cells to influence pheomelanin synthesis affects the proportion of total melanin, changing mammalian coat colour. In our previous study, we used RNA-seq to show that SLC7A11 was involved in coat colour regulation in Rex rabbits. However, the precise role of SLC7A11 in rabbit coat colour formation has not been investigated...
June 2018: Journal of Genetics
Amal Djaout, Barbara Chiappini, S Bechir Suheil Gaouar, Farida Afri-Bouzebda, Michela Conte, Fakhreddine Chekkal, Rachid El-Bouyahiaoui, Rachid Boukhari, Umberto Agrimi, Gabriele Vaccari
Scrapie is a prion disease that affects the sheep and goats. It belongs to the group of transmissible spongiform encephalopathies (TSE). TSEs are characterized by the accumulation of the pathological form (PrPSc ) of the cellular prion protein (PrPC ). The susceptibility of sheep to scrapie is influenced by polymorphisms in the PrP gene (PRNP). The aim of this study was to identify the genetic variability of sheep PRNP in Algerian sheep. Two-hundred and thirteen Algerian sheep from eight breeds (Ouled Djellal, Rembi, Hamra, Berbere, Barbarine, Sidaou, Taadmit and Tazegzawt) with no clinical manifestation of scrapie were analysed...
June 2018: Journal of Genetics
Rongrong Guo, Bo Wang, Ling Lin, Guo Cheng, Sihong Zhou, Shuyu Xie, Xiaofang Shi, Muming Cao, Ying Zhang, Xianjin Bai
The fruitfulness of grapevines ( Vitis vinifera L.) is determined to a large extent by the differentiation of uncommitted meristems, especially in the second-crop production of some varieties, where the intermediate of inflorescence and tendril accounts for a significant proportion in two-crop-a-year grape culture system. The differentiation of uncommitted lateral meristem was reported to be regulated by a network, whose backbone was composed of several floral meristem identity genes. In the present study, the phylogenetics of grape floral meristem identity genes with their orthologues in other species, and their conserved domain and interaction networks were analysed...
June 2018: Journal of Genetics
Saikat Chakraborty, Shantanu P Shukla, K P Arunkumar, Javaregowda Nagaraju, Raghavendra Gadagkar
Ropalidia marginata is a social wasp in which colonies consist of a single fertile queen and several sterile workers. If the queen is removed, one of the workers, potential queen (PQ), becomes hyperaggressive and becomes the next queen. The identity of the PQ cannot be predicted in the presence of the queen. The probability of a worker succeeding the queen is uncorrelated with her body size, dominance rank, ovarian or mating status, but imperfectly correlated with her age. Here, we investigate whether genetic relatedness help to predict the queen's successors...
June 2018: Journal of Genetics
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