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Journal of Genetics

Amal Djaout, Barbara Chiappini, Semir-Bechir-Suheil Gaouar, Farida Afri-Bouzebda, Michela Conte, Fakhreddine Chekkal, Zhanliang Shi, Rachid El-Bouyahiaoui, Rachid Boukhari, Umberto Agrimi, Gabriele Vaccari
No abstract text is available yet for this article.
September 2018: Journal of Genetics
Simmi Saini, Gagandeep Kaur Walia, Mohinder Pal Sachdeva, Vipin Gupta
Obesity is one of the largest global health problems associated with increased morbidity and mortality mediated by its association with several other metabolic disorders. The interaction between the genes and environment plays an important role in the manifestation of obesity. Despite a high heritability (40-70%) of obesity, the search for genetic variants associated with obesity susceptibility has been a challenging task. To date, limited studies have been conducted in India, restricted to the validation of few genetic variants identified by genomewide association studies...
September 2018: Journal of Genetics
Bashisth N Singh
Dobzhansky was the first to show that the inversion polymorphism in Drosophila pseudoobscura is subject to natural selection and is a device to cope with the diversity of environments. His extensive work on D. pseudoobscura has revealed interesting phenomena of population genetics. In continuation of his work on this species, he constructed a number of homozygous lines for different gene arrangements in the third chromosome, and while employing these lines in intrapopulation and interpopulation crosses, he quantified the fitness of inversion homokaryotypes and heterokaryotypes...
September 2018: Journal of Genetics
Hari Sharan Misra, Ganesh Kumar Maurya, Swathi Kota, Vijaya Kumar Charaka
Bacteria are unicellular organisms that do not show compartmentalization of the genetic material and other cellular organelles as seen in higher organisms. Earlier, bacterial genomes were defined as single circular chromosome and extrachromosomal plasmids. Recently, many bacteria were found harbouringmultipartite genome system and the numbers of copies of genome elements including chromosomes vary from one to several per cell. Interestingly, it is noticed that majority of multipartite genome-harbouring bacteria are either stress tolerant or pathogens...
September 2018: Journal of Genetics
Yan Zhang, Xibo Zhang, Ran Long, Ling Yu
Congenital anophthalmia is a rare eye anomaly which lacks a recognizable eye in the orbit. It can be isolated (nonsyndromic) or be observed as a sign of other diseases (syndromic). A Chinese infant was born with bilateral anophthalmia and palpebral fissure closures. Ocular and systemic examinations were performed, and genomic DNA was prepared from peripheral leukocytes. The coding exons and the adjacent intrinsic sequence of SOX2 were analysed by Sanger sequencing. A c.70_89del (p. Asn24ArgfsX65; rs398123693) mutation in SOX2 was identified in the Chinese infant with bilateral clinical anophthalmia and sensorineural hearing loss...
September 2018: Journal of Genetics
E Geethika, H N Triveni, R Srirama, R Siva, Siddappa Setty, G Ravikanth
Phyllanthus emblica and P. indofischeri , commonly known as the Indian gooseberry, are important nontimber forest product (NTFP) species widely distributed across the Indian subcontinent. The fruits of these species are rich in vitamin C and are used in the preparation of a number of herbal medicines for treating a wide range of disorders. Due to the increased demand, they have been harvested extensively and form a major source of income for the forest-dwelling communities living in southern India. There are limited studies to understand the impact of harvesting on the genetic structure of these species...
September 2018: Journal of Genetics
Chunyan Ma, Hongyu Ma, Guodong Xu, Chunlei Feng, Lingbo Ma, Lumin Wang
To provide massive genetic resources for the Antarctic krill ( Euphausia superba ), we sequenced and analysed the transcriptome by using high-throughput Illumina paired-end sequencing technology. A total of 77.1 million clean reads representing ~11.0Gb data were generated. The average length of these reads was 142 bp. De novo assembly yielded 125,211 transcripts with a N50 of 690 bp. Further analysis produced 106,250 unigenes, of which 31,683 were annotated based on protein homology searches against protein databases...
September 2018: Journal of Genetics
Huan Zhang, Xingbo Mo, Zhengyuan Zhou, Zhengbao Zhu, Xinfeng Huangfu, Tan Xu, Aili Wang, Zhirong Guo, Yonghong Zhang
Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smoking in the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNP-smoking interactions were detected in regression models...
September 2018: Journal of Genetics
Xiao Hong Guo, Qi Zhang, Meng Li, Peng Fei Gao, Guo Qing Cao, Zhi Min Cheng, Ning Fang Zhang, Bao Yu Le, Jian Feng Liu, Xiao Jun Liu, Bu Gao Li
The present study aimed to identify the alternatively spliced isoforms of pig MEF2A gene and to determine theirmRNA expression patterns. Four alternatively spliced isoforms of pig MEF2A gene (i.e. MEF2A1 , MEF2A2 , MEF2A3 and MEF2A4 ) were cloned according to the results of transcriptome sequencing. The fifth to eighth exons of MEF2A1 were normally spliced. In MEF2A2 , the fifth exon was missing; the sixth exon had an extra 138 bp at its 5' end, and the seventh exon had an extra 102 bp at its 3' end. In MEF2A3 , the fifth exon was missing, and the sixth exon had an additional 138 bp at its 5' end...
September 2018: Journal of Genetics
X Li, Cunyuan Li, Wei Ni, Dawei Wang, Xiaoxu Hou, Zhijin Liu, Yang Cao, Yang Yao, Xiangyu Zhang, Shengwei Hu
MicroRNAs (miRNAs) are a class of short-chain RNA molecules of ~22 nucleotides in length and regulate gene expression at posttranscriptional levels by interacting with mRNAs. Although many miRNAs have been identified, the expression and function of miRNAs in the pituitary gland of sheep are still unclear. In this study, the identity and abundance of miRNAs were determined in the sheep pituitary gland of prenatal and postnatal stages. We showed that 107 miRNAs are significantly ( P <0.05) differentially expressed in pituitary glands between the prenatal and postnatal stages, and 44 new miRNA candidates were found according to a series of filtration criteria...
September 2018: Journal of Genetics
A Charles Antony, Pankaj V Alone
The eIF5 protein plays an important role in the fidelity of AUG start codon selection. However, the hyper GTPase eIF5G31R mutation in yeast causes preferential utilization of UUG as initiation codon and is termed as suppressor of initiation codon (Sui- ) phenotype. The eIF5G31R mutant recognizes upUUG initiation codon from the 5' regulatory leader region of GCN4 transcript and dominantly represses GCN4 expression thereby conferring sensitivity to 3-amino-1,2,4-triazole (3AT)-induced starvation. The 3AT sensitivity was rescued by supplementing HIS4 UUG allele...
September 2018: Journal of Genetics
Balaji Aravindhan Pandian, John Joel, Vishnu Varthini Nachimuthu, Manonmani Swaminathan, P Govintharaj, Shalini Tannidi, Robin Sabariappan
Rice blast caused by fungal pathogen Pyricularia oryzae has a major impact on reducing yield potential of rice. In this study, homozygous plants were selected using microsatellite markers from the BC3 F2 population pyramided with four major genes in elite rice variety ADT 43. Background and selected lines with various blast resistance gene combinations were screened under natural conditions to study the effects of various gene combinations. Upon inspection of lines with different gene combinations, the three-gene pyramided line Pi54 + Pi33 + Pi1 was found to be highly resistant with the score of 3...
September 2018: Journal of Genetics
Shang Dandan, Chen Yuqin, Lu Wei, Peng Ziheng, Zhou Dapeng, Yang Jianzhu, Xin Xin, Liu Yonghong, Tian Fengjun
Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive disorder with distinctive deposition of calcium phosphate microliths in the lungs. Mutation of the SLC34A2 gene was proved to be responsible for PAM. Here, we report the study of a family affected by PAM in China. Two daughters of an inbred family whose parents are cousins and are affected by PAM. Mutation analysis of the SLC34A2 gene by polymerase chain reaction (PCR) amplification and direct sequencing in both patients revealed that exon 5 was deleted on both alleles...
September 2018: Journal of Genetics
Hao Li, J Feng, Xiaodan Xu, Ruiming Lin, Fengtao Wang, Shichang Xu
Wheat stripe (yellow) rust, caused by Puccinia striiformis West. f. sp. tritici ( Pst ), is one of the most destructive diseases in many wheat-growing countries, especially in China, the largest stripe rust epidemic area in the world. Growing the resistant cultivars is an effective, economic and environmentally friendly way to control this disease. Wheat cultivar Zhengmai 7698 has shown a high-level resistance to wheat stripe rust. To elucidate its genetic characteristics and location of the resistance gene, Zhengmai 7698 was crossed with susceptible variety Taichung 29 to produce F1 , F2 and BC1 progeny generations...
September 2018: Journal of Genetics
Ayman H Jawadi, Anwar Wakeel, Waleed Tamimi, A Nasr, Zafar Iqbal, Abdullah Mashhour, Mohamed A Fattah, Nawaf Alkhanein, Ahmad S Abu Jaffal
Developmental dysplasia of the hip (DDH) is a congenital condition characterized by abnormality in acetabulum size and/or shape. The incidence rate of DDH differs between different populations with risk factors including positive family history, breech presentation, sex, firstborn status, side of the hip, mode of delivery and oligohydramnios. It is recognized that DDH has a genetic component that exhibit autosomal dominant patterns. Many candidate genes have been studied and found to be associated with the disease; most of them are normally involved in cartilage development and joint metabolism...
September 2018: Journal of Genetics
Wen-Fang Dong, Hang Zhang, Ru-Meng Wang, Hong-Chun Pan
Our previous study based on the transcriptome profiling indicated that a fragment of α-crystallin type heat shock protein (α-Hsp) gene was one of the numerous cDNA sequences expressed differentially at various stages of head regeneration in Hydra vulgaris . To further investigate the role that which α-Hsp plays during hydra regeneration, a full-length cDNA of α-Hsp gene of H. vulgaris was isolated by the rapid amplification of cDNA ends (RACE) technique. The full-length cDNA of α-Hsp gene was 1156 bp, containing a 765 bp open-reading frame (ORF), which encodes a polypeptide of 254 amino acid residues with a molecular weight of 29...
September 2018: Journal of Genetics
Zhenxian Gao, Guoying Tian, Yanxia Wang, Yaqing Li, Qiao Cao, Meikun Han, Zhanliang Shi
In common wheat ( Triticum aestivum L.), allelic variations of Glu-1 loci have important influences on grain end-use quality. The allelic variations in high molecular weight glutenin subunits (HMW-GSs) were identified in 151 hexaploid wheat varieties representing a historical trend in the cultivars introduced or released inHebei province ofChina fromthe years 1970s to 2010s.Thirteen distinct alleles were detected for Glu-1. At Glu-A1, Glu-B1 and Glu-D1, we found that the most frequent alleles were the 1 (43...
September 2018: Journal of Genetics
Faruk Bozkaya, Sükrü Gürler
In this study, we aimed to assess the sequence diversity of major histocompatibility complex (MHC) class-II DRB gene at exon 2 in gazelles raised in Sanliurfa Province of Turkey. Twenty DNA samples isolated from gazelles ( Gazella subgutturosa ) were used for sequencing exon 2 of MHC class-II DRB gene. Target region was amplified by polymerase chain reaction (PCR) and their products were directly sequenced. Nine of these 20 samples yielded unambiguously readable sequences. Three of the nine samples were homozygotes and each showed different sequences...
September 2018: Journal of Genetics
Liang Wan, L Dong, Shijun Xiao, Zhaofang Han, Xiaoqing Wang, Z Wang
A traditional genomewide association study (GWAS) detects genotype-phenotype associations by the vast number of genotyped individuals. This method requires large-scale samples and considerable sequencing costs. Extreme phenotypic sampling proposes make GWAS more cost-efficient and are applied more widely. With extreme phenotypic sampling, we performed a GWAS for n-3 highly unsaturated fatty acids (HUFA) and eviscerated weight (EW) traits in the large yellowcroaker population. Of the 32,249 and 29,748 detected SNPs for the two traits, three candidate regions were found in each trait...
September 2018: Journal of Genetics
Padma Gunda, Mamata Manne, Syed Saifuddin Adeel, Ravi Kumar Reddy Kondareddy, Padma Tirunilai
The aim of this studywas to identify the gene causing bilateral autosomal dominant zonular congenital cataract (ADZCC) without pulverulent opacities in an extended Muslim family by exome sequencing and subsequent analysis. An extended family of 37 members (14 affected and 23 unaffected) who belong to different nuclear families was screened for causative gene. Proband and her unaffected son were screened for causative variant by exome sequencing followed by Sanger sequencing of the proband's entire nuclear family...
September 2018: Journal of Genetics
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