Lina M Castano-Jaramillo, Francisco Rivas Larrauri, Selma C Scheffler-Mendoza, Alonso Gutierrez-Hernandez, Juan Carlos Bustamante Ogando, Paulina Colin, Margarita Ortega Cisneros, Sandra Rajme-López, Edgar Alejandro Medina-Torres, Laura Berron Ruiz, Ana Luisa Rodriguez-Lozano, Sara Elva Espinosa Padilla, Marco Antonio Yamazaki-Nakashimada, Saul O Lugo Reyes
Inborn errors of immunity may present with autoimmunity and autoinflammation as hallmark clinical manifestations. We aimed to identify the potential monogenic causes of autoimmune disorders in 26 patients from a pediatric reference hospital in Mexico through whole-exome sequencing. We specifically selected patients with a family history of autoimmune diseases, early-onset symptoms, and difficult-to-control autoimmune disorders or autoimmunity associated with infection predisposition. We identified the genetic variants that were compatible with the patients' phenotype in 54% of the patients...
2023: Journal of Genetics