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Journal of General Physiology

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https://www.readbyqxmd.com/read/28916519/modeling-pacemaker-deterioration-with-age
#1
Caitlin Sedwick
New JGP study models how sinoatrial node pacemaker activity changes in aged hearts.
September 15, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28899933/chemistry-in-a-vesicle
#2
Meyer B Jackson
No abstract text is available yet for this article.
September 12, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28887411/age-related-pacemaker-deterioration-is-due-to-impaired-intracellular-and-membrane-mechanisms-insights-from-numerical-modeling
#3
Joachim Behar, Yael Yaniv
Age-related deterioration of pacemaker function has been documented in mammals, including humans. In aged isolated sinoatrial node tissues and cells, reduction in the spontaneous action potential (AP) firing rate was associated with deterioration of intracellular and membrane mechanisms; however, their relative contribution to age-associated deficient pacemaker function is not known. Interestingly, pharmacological interventions that increase posttranslation modification signaling activities can restore the basal and maximal AP firing rate, but the identities of the protein targets responsible for AP firing rate restoration are not known...
September 8, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28887410/a-coarse-grained-computational-model-of-the-nuclear-pore-complex-predicts-phe-gly-nucleoporin-dynamics
#4
Joan Pulupa, Manas Rachh, Michael D Tomasini, Joshua S Mincer, Sanford M Simon
The phenylalanine-glycine-repeat nucleoporins (FG-Nups), which occupy the lumen of the nuclear pore complex (NPC), are critical for transport between the nucleus and cytosol. Although NPCs differ in composition across species, they are largely conserved in organization and function. Transport through the pore is on the millisecond timescale. Here, to explore the dynamics of nucleoporins on this timescale, we use coarse-grained computational simulations. These simulations generate predictions that can be experimentally tested to distinguish between proposed mechanisms of transport...
September 8, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28882880/slow-fusion-pore-expansion-creates-a-unique-reaction-chamber-for-co-packaged-cargo
#5
Kevin P Bohannon, Mary A Bittner, Daniel A Lawrence, Daniel Axelrod, Ronald W Holz
A lumenal secretory granule protein, tissue plasminogen activator (tPA), greatly slows fusion pore dilation and thereby slows its own discharge. We investigated another outcome of the long-lived narrow fusion pore: the creation of a nanoscale chemical reaction chamber for granule contents in which the pH is suddenly neutralized upon fusion. Bovine adrenal chromaffin cells endogenously express both tPA and its primary protein inhibitor, plasminogen activator inhibitor 1 (PAI). We found by immunocytochemistry that tPA and PAI are co-packaged in the same secretory granule...
September 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720591/using-fluorescence-to-understand-%C3%AE-subunit-nav-channel-interactions
#6
Rene Barro-Soria, Sara I Liin, H Peter Larsson
No abstract text is available yet for this article.
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720590/mechanisms-of-noncovalent-%C3%AE-subunit-regulation-of-nav-channel-gating
#7
Wandi Zhu, Taylor L Voelker, Zoltan Varga, Angela R Schubert, Jeanne M Nerbonne, Jonathan R Silva
Voltage-gated Na(+) (NaV) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applying voltage clamp fluorometry to measure how the β subunits affect the conformational dynamics of the cardiac NaV channel (NaV1.5) voltage-sensing domains (VSDs). The pore-forming NaV1.5 α subunit contains four domains (DI-DIV), each with a VSD...
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720589/dynamic-role-of-the-tether-helix-in-pip2-dependent-gating-of-a-g-protein-gated-potassium-channel
#8
Emre Lacin, Prafulla Aryal, Ian W Glaaser, Karthik Bodhinathan, Eric Tsai, Nidaa Marsh, Stephen J Tucker, Mark S P Sansom, Paul A Slesinger
G protein-gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP2) is an essential cofactor for GIRK channel gating, but the precise mechanism by which PIP2 opens GIRK channels remains poorly understood. Previous structural studies have revealed several highly conserved, positively charged residues in the "tether helix" (C-linker) that interact with the negatively charged PIP2 However, these crystal structures of neuronal GIRK channels in complex with PIP2 provide only snapshots of PIP2's interaction with the channel and thus lack details about the gating transitions triggered by PIP2 binding...
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798281/control-of-cardiac-ryanodine-receptor-by-sarcoplasmic-reticulum-luminal-ca-2
#9
REVIEW
Peter P Jones, Wenting Guo, S R Wayne Chen
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798280/quenching-the-spark-termination-of-cicr-in-the-submicroscopic-space-of-the-dyad
#10
REVIEW
Mark B Cannell, Cherrie H T Kong
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798279/the-role-of-luminal-ca-regulation-in-ca-signaling-refractoriness-and-cardiac-arrhythmogenesis
#11
REVIEW
Sándor Györke, Andriy E Belevych, Bin Liu, Igor V Kubasov, Cynthia A Carnes, Przemysław B Radwański
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798278/perspectives-on-control-of-ca-release-from-within-the-cardiac-sarcoplasmic-reticulum
#12
REVIEW
Eduardo Ríos
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798277/the-intricacies-of-atrial-calcium-cycling-during-excitation-contraction-coupling
#13
REVIEW
Lothar A Blatter
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798276/ambiguous-interactions-between-diastolic-and-sr-ca-2-in-the-regulation-of-cardiac-ca-2-release
#14
REVIEW
Eric A Sobie, George S B Williams, W J Lederer
No abstract text is available yet for this article.
September 4, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28729458/the-junior-faculty-networking-cohort-filling-a-gap-in-support-for-our-community
#15
EDITORIAL
Sharona E Gordon
JGP, in partnership with the Society of General Physiologists, announces a new networking and mentoring program for junior faculty.
August 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28716806/different-strokes-for-different-synaptotagmins
#16
Caitlin Sedwick
JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion.
August 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28687607/synaptotagmin-isoforms-confer-distinct-activation-kinetics-and-dynamics-to-chromaffin-cell-granules
#17
Tejeshwar C Rao, Zuleirys Santana Rodriguez, Mazdak M Bradberry, Alexandra H Ranski, Peter J Dahl, Michael W Schmidtke, Paul M Jenkins, Daniel Axelrod, Edwin R Chapman, David R Giovannucci, Arun Anantharam
Adrenomedullary chromaffin cells respond to sympathetic nervous system activation by secreting a cocktail of potent neuropeptides and hormones into the circulation. The distinct phases of the chromaffin cell secretory response have been attributed to the progressive fusion of distinct populations of dense core granules with different activation kinetics. However, it has been difficult to define what distinguishes these populations at the molecular level. Functional segregation of granule pools may depend on selective sorting of synaptotagmin-1 (Syt-1) and synaptotagmin-7 (Syt-7), which our previous work showed are rarely cosorted to the same granule...
August 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28687606/camp-dependent-regulation-of-iks-single-channel-kinetics
#18
Emely Thompson, Jodene Eldstrom, Maartje Westhoff, Donald McAfee, Elise Balse, David Fedida
The delayed potassium rectifier current, IKs , is composed of KCNQ1 and KCNE1 subunits and plays an important role in cardiac action potential repolarization. During β-adrenergic stimulation, 3'-5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase in IKs current and a shortening of the action potential. Here, using cell-attached macropatches and single-channel recordings, we investigate the microscopic mechanisms underlying the cAMP-dependent increase in IKs current...
August 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28630134/correction-clustering-of-ca-2-transients-in-interstitial-cells-of-cajal-defines-slow-wave-duration
#19
Bernard T Drumm, Grant W Hennig, Matthew J Battersby, Erin K Cunningham, Tae Sik Sung, Sean M Ward, Kenton M Sanders, Salah A Baker
No abstract text is available yet for this article.
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28626063/no-fuzzy-space-for-intracellular-na-in-healthy-ventricular-myocytes
#20
Frank B Sachse, Robert Clark, Wayne R Giles
No abstract text is available yet for this article.
July 3, 2017: Journal of General Physiology
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