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Journal of General Physiology

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https://www.readbyqxmd.com/read/28798281/control-of-cardiac-ryanodine-receptor-by-sarcoplasmic-reticulum-luminal-ca-2
#1
REVIEW
Peter P Jones, Wenting Guo, S R Wayne Chen
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798280/quenching-the-spark-termination-of-cicr-in-the-submicroscopic-space-of-the-dyad
#2
REVIEW
Mark B Cannell, Cherrie H T Kong
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798279/the-role-of-luminal-ca-regulation-in-ca-signaling-refractoriness-and-cardiac-arrhythmogenesis
#3
REVIEW
Sándor Györke, Andriy E Belevych, Bin Liu, Igor V Kubasov, Cynthia A Carnes, Przemysław B Radwański
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798278/perspectives-on-control-of-ca-release-from-within-the-cardiac-sarcoplasmic-reticulum
#4
REVIEW
Eduardo Ríos
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798277/the-intricacies-of-atrial-calcium-cycling-during-excitation-contraction-coupling
#5
REVIEW
Lothar A Blatter
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798276/ambiguous-interactions-between-diastolic-and-sr-ca-2-in-the-regulation-of-cardiac-ca-2-release
#6
REVIEW
Eric A Sobie, George S B Williams, W J Lederer
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28729458/the-junior-faculty-networking-cohort-filling-a-gap-in-support-for-our-community
#7
EDITORIAL
Sharona E Gordon
JGP, in partnership with the Society of General Physiologists, announces a new networking and mentoring program for junior faculty.
July 20, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720591/using-fluorescence-to-understand-%C3%AE-subunit-nav-channel-interactions
#8
Rene Barro-Soria, Sara I Liin, H Peter Larsson
No abstract text is available yet for this article.
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720590/mechanisms-of-noncovalent-%C3%AE-subunit-regulation-of-nav-channel-gating
#9
Wandi Zhu, Taylor L Voelker, Zoltan Varga, Angela R Schubert, Jeanne M Nerbonne, Jonathan R Silva
Voltage-gated Na(+) (NaV) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applying voltage clamp fluorometry to measure how the β subunits affect the conformational dynamics of the cardiac NaV channel (NaV1.5) voltage-sensing domains (VSDs). The pore-forming NaV1.5 α subunit contains four domains (DI-DIV), each with a VSD...
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28720589/dynamic-role-of-the-tether-helix-in-pip2-dependent-gating-of-a-g-protein-gated-potassium-channel
#10
Emre Lacin, Prafulla Aryal, Ian W Glaaser, Karthik Bodhinathan, Eric Tsai, Nidaa Marsh, Stephen J Tucker, Mark S P Sansom, Paul A Slesinger
G protein-gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP2) is an essential cofactor for GIRK channel gating, but the precise mechanism by which PIP2 opens GIRK channels remains poorly understood. Previous structural studies have revealed several highly conserved, positively charged residues in the "tether helix" (C-linker) that interact with the negatively charged PIP2 However, these crystal structures of neuronal GIRK channels in complex with PIP2 provide only snapshots of PIP2's interaction with the channel and thus lack details about the gating transitions triggered by PIP2 binding...
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28716806/different-strokes-for-different-synaptotagmins
#11
Caitlin Sedwick
JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion.
July 17, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28687607/synaptotagmin-isoforms-confer-distinct-activation-kinetics-and-dynamics-to-chromaffin-cell-granules
#12
Tejeshwar C Rao, Zuleirys Santana Rodriguez, Mazdak M Bradberry, Alexandra H Ranski, Peter J Dahl, Michael W Schmidtke, Paul M Jenkins, Daniel Axelrod, Edwin R Chapman, David R Giovannucci, Arun Anantharam
Adrenomedullary chromaffin cells respond to sympathetic nervous system activation by secreting a cocktail of potent neuropeptides and hormones into the circulation. The distinct phases of the chromaffin cell secretory response have been attributed to the progressive fusion of distinct populations of dense core granules with different activation kinetics. However, it has been difficult to define what distinguishes these populations at the molecular level. Functional segregation of granule pools may depend on selective sorting of synaptotagmin-1 (Syt-1) and synaptotagmin-7 (Syt-7), which our previous work showed are rarely cosorted to the same granule...
July 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28687606/camp-dependent-regulation-of-iks-single-channel-kinetics
#13
Emely Thompson, Jodene Eldstrom, Maartje Westhoff, Donald McAfee, Elise Balse, David Fedida
The delayed potassium rectifier current, IKs , is composed of KCNQ1 and KCNE1 subunits and plays an important role in cardiac action potential repolarization. During β-adrenergic stimulation, 3'-5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) phosphorylates KCNQ1, producing an increase in IKs current and a shortening of the action potential. Here, using cell-attached macropatches and single-channel recordings, we investigate the microscopic mechanisms underlying the cAMP-dependent increase in IKs current...
July 7, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28630134/correction-clustering-of-ca-2-transients-in-interstitial-cells-of-cajal-defines-slow-wave-duration
#14
Bernard T Drumm, Grant W Hennig, Matthew J Battersby, Erin K Cunningham, Tae Sik Sung, Sean M Ward, Kenton M Sanders, Salah A Baker
No abstract text is available yet for this article.
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28626063/no-fuzzy-space-for-intracellular-na-in-healthy-ventricular-myocytes
#15
Frank B Sachse, Robert Clark, Wayne R Giles
No abstract text is available yet for this article.
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28619745/many-parts-make-a-whole-calcium-transients-sum-for-slow-waves
#16
Caitlin Sedwick
New JGP study shows how calcium events drive long intestinal slow wave plateaus.
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28611079/elevated-camp-improves-signal-to-noise-ratio-in-amphibian-rod-photoreceptors
#17
Luba A Astakhova, Darya A Nikolaeva, Tamara V Fedotkina, Victor I Govardovskii, Michael L Firsov
The absolute sensitivity of vertebrate retinas is set by a background noise, called dark noise, which originates from several different cell types and is generated by different molecular mechanisms. The major share of dark noise is produced by photoreceptors and consists of two components, discrete and continuous. Discrete noise is generated by spontaneous thermal activations of visual pigment. These events are undistinguishable from real single-photon responses (SPRs) and might be considered an equivalent of the signal...
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28606910/na-k-pump-inactivation-subsarcolemmal-na-measurements-and-cytoplasmic-ion-turnover-kinetics-contradict-restricted-na-spaces-in-murine-cardiac-myocytes
#18
Fang-Min Lu, Donald W Hilgemann
Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constitutive transsarcolemmal Na flux with the Na channel opener veratridine in whole-cell patch-clamp recordings. Using 25 mM Na in the patch pipette, pump currents decay strongly during continuous activation by extracellular K (τ, ∼2 s). In contradiction to depletion hypotheses, the decay becomes stronger when pump currents are decreased by hyperpolarization...
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28592421/clustering-of-ca-2-transients-in-interstitial-cells-of-cajal-defines-slow-wave-duration
#19
Bernard T Drumm, Grant W Hennig, Matthew J Battersby, Erin K Cunningham, Tae Sik Sung, Sean M Ward, Kenton M Sanders, Salah A Baker
Interstitial cells of Cajal (ICC) in the myenteric plexus region (ICC-MY) of the small intestine are pacemakers that generate rhythmic depolarizations known as slow waves. Slow waves depend on activation of Ca(2+)-activated Cl(-) channels (ANO1) in ICC, propagate actively within networks of ICC-MY, and conduct to smooth muscle cells where they generate action potentials and phasic contractions. Thus, mechanisms of Ca(2+) regulation in ICC are fundamental to the motor patterns of the bowel. Here, we characterize the nature of Ca(2+) transients in ICC-MY within intact muscles, using mice expressing a genetically encoded Ca(2+) sensor, GCaMP3, in ICC...
July 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28522439/interpreting-the-functional-role-of-a-novel-interaction-motif-in-prokaryotic-sodium-channels
#20
REVIEW
Altin Sula, B A Wallace
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential. In humans, mutations in sodium channels give rise to several neurological and cardiovascular diseases, and hence they are targets for pharmaceutical drug developments. Prokaryotic sodium channel crystal structures have provided detailed views of sodium channels, which by homology have suggested potentially important functionally related structural features in human sodium channels...
June 5, 2017: Journal of General Physiology
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