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Folia Medica

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https://www.readbyqxmd.com/read/28384116/ykl-40-and-cytokines-a-new-diagnostic-constellation-in-rheumatoid-arthritis
#1
Maria H Kazakova, Anastas Z Batalov, Nonka G Mateva, Zlatimir G Kolarov, Victoria S Sarafian
BACKGROUND: Rheumatoid arthritis (RA) causes chronic inflammation and alteration of articular tissue and joints. The pathogenesis of the disease remains unclear although it is known that proinflammatory cytokines play a major role in its induction. YKL-40 is a chitinase-like glycoprotein produced by activated macrophages, neutrophils, arthritic chondrocytes and cancer cells. It has been shown that YKL-40 is implicated in tissue remodeling, angiogenesis and inflammation. AIM: to investigate serum and synovial YKL-40 levels in relation to IL-1β, TNF-α, and IL-6 in RA patients...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384115/epidemiological-study-of-hepatitis-a-infection-in-eastern-bulgaria
#2
Gabriela St Tsankova, Tatina T Todorova, Neli M Ermenlieva, Tsvetelina K Popova, Dayana T Tsankova
BACKGROUND: Hepatitis A virus (HAV) infection is an acute, self-limited liver disease transmitted usually through the faecal-oral route via person-to-person contact. Bulgaria has intermediate HAV endemicity with higher susceptibility among adults and recurrent outbreaks. AIM: As HAV infection is strongly related to human movements and represents a significant risk to travelers and migrants, as well as to local population receiving these groups, we set out to analyze the epidemiological data on hepatitis A in five of the largest tourist border regions of Bulgaria located in its eastern part: Varna, Shumen, Dobrich, Burgas and Yambol...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384114/immune-cell-subsets-evaluation-as-a-predictive-tool-for-hepatitis-b-infection-outcome-and-treatment-responsiveness
#3
Snezhina M Kandilarova, Atanaska I Georgieva, Anastasiya P Mihaylova, Marta P Baleva, Valentina K Atanasova, Diana V Petrova, Georgi T Popov, Elissaveta J Naumova
BACKGROUND: The patient's immune response is one of the major factors influencing HBV eradication or chronification, and it is thought to be responsible for the treatment success. AIM: Our study aimed to investigate whether cellular defense mechanisms are associated with the course of HBV infection (spontaneous recovery [SR] or chronification [CHB]) and with the therapeutic approach. PATIENTS AND METHODS: A total of 139 patients (118 with CHB, 21 SR) and 29 healthy individuals (HI) were immunophenotyped by flowcytometry...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384113/the-5-minute-apgar-score-as-a-prognostic-factor-for-development-and-progression-of-retinopathy-of-prematurity
#4
Vasil G Marinov, Desislava N Koleva-Georgieva, Nelly P Sivkova, Maya B Krasteva
BACKGROUND: A low Apgar score at 5 minutes has been shown to be a risk factor for development of retinopathy of prematurity (ROP). AIM: To examine the prognostic value of Apgar score at 5 minutes for development and progression of ROP. MATERIALS AND METHODS: The study included 132 preterm infants who were screened from 4th week of life onward. Of these, 118 newborns were given Apgar score at 5 minutes. The prognostic significance of this index was studied as an absolute value and as a value ≤ 6...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384112/inflammatory-myopathies-with-cutaneous-involvement-from-diagnosis-to-therapy
#5
REVIEW
Lyubomir A Dourmishev
The group of idiopathic inflammatory myopathies (IIM) include various disorders of skeletal muscles with or without skin involvement. The most common types are dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). Dermatomyositis subdivides into various clinical forms such as juvenile, amyopathic or paraneoplastic dermatomyositis, scleromyositis, overlap or anti-synthetase syndromes, etc. Recently, numerous new antibodies defining the characteristic clinical phenotype have been described as anti-MDA5 antibodies associated with interstitial lung disease and amyopathic dermatomyositis or anti-TIF1γ antibodies as markers for paraneoplastic dermatomyositis...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384111/demographic-and-comorbidity-pattern-of-patients-with-critical-limb-ischemia
#6
Răzvan A Ciocan, Sorana D Bolboacă, Şerban Rădulescu, Bogdan Stancu, Andra Ciocan, Claudia D Gherman
AIM: The present study aimed at identifying the pattern of patients with critical limb ischemia (CLI) compared with those with peripheral arterial occlusive disease (PAOD). MATERIALS AND METHODS: A four-year retrospective study was conducted with patients hospitalized in the Second Surgical Clinic at the Emergency County Hospital Cluj-Napoca. The medical charts of patients with PAOD (n=466) and CLI (n=223) were reviewed and data were collected. RESULTS: The study included 689 patients; mean age 67 years for PAOD patients and 65 years for CLI patients...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384110/effects-of-the-novel-high-affinity-5-ht-1b-1d-receptor-ligand-frovatriptan-on-the-rat-carotid-artery
#7
Kremena E Saracheva, Natalia A Prissadova, Valentin I Turiiski, Valeri I Slavchev, Atanas D Krastev, Damianka P Getova
BACKGROUND: In blood vessels 5-HT stimulates sympathetic nerves, the endothelium and vascular smooth muscle cells. Triptans are specific anti-migraine drugs and they activate the serotoninergic 5HT1b/d receptors causing vasoconstriction of the cerebral vessels. AIM: To evaluate the effect of frovatriptan on isolated rat carotid artery. METHODS: Contractile activity of the preparations was registered isometrically. Krebs solution (pH = 7.4) was used for washing smooth muscle (SM) preparations aerated with 95% O2 and 5% CO2 at 37°C...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384109/an-incidental-finding-of-heart-echinococcosis-in-a-patient-with-infective-endocarditis-a-case-report
#8
Dolina G Gencheva, Dimitar N Menchev, Dimitar K Penchev, Mariya P Tokmakova
Echinococcosis is a cosmopolitan zoonotic parasitic disease caused by infection with the larval stage of tapeworms from the Echinococcus genus, most commonly Echinococcus granulosus. According to WHO, more than 1 million people are affected by hydatid disease at any time.1 About 10% of the annual cases are not officially diagnosed.2 In humans, the disease is characterized by development of three-layered cysts. The cysts develop primarily in the liver and the lungs, but can also affect any other organ due to the spreading of the oncospheres...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384108/profiling-of-circulating-serum-micrornas-in-children-with-autism-spectrum-disorder-using-stem-loop-qrt-pcr-assay
#9
Tatyana M Kichukova, Nikolay T Popov, Ivan S Ivanov, Tihomir I Vachev
BACKGROUND: Development of biomarkers for autism spectrum disorder (ASD) has still remained a challenge to date. Recently, alterations of the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to ASD. miRNAs are known to be secreted by various cell types and can mediate transmission of information into recipient cells and to modulate their physiological functions. On this basis it is assumed that circulating miRNAs could be useful biomarkers for the diagnosis or prognosis of pathological conditions...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384107/diagnostic-value-of-erg-in-prostate-needle-biopsies-containing-minute-cancer-foci
#10
Svitlana Y Bachurska, Dmitriy G Staykov, Ivan V Bakardzhiev, Petar A Antonov, Veselin T Belovezhdov
BACKGROUND: Prostate carcinoma (PC) is the second most diagnosed cancer in men population worldwide. The small amount of the tissue in prostate needle biopsy is often sufficient for the correct interpretation. Novel antibodies, as ERG, could add to the diagnostic value of IHC study in analysing difficult core biopsies. AIM: The aim of the present study was to establish a diagnostic use of ERG in a work-up of prostate needle biopsies containing minute PC, individually and in combination with AMACR/34βE12...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384106/diagnostic-dilemmas-in-hepatitis-c-virus-infection-for-hemodialysis-patients
#11
Radka T Komitova, Maria V Atanasova, Toska A Pavlova, Monica Sh Nyagolov, Aneta V Ivanova
BACKGROUND: Hepatitis C virus (HCV) is a leading cause of chronic hepatitis in dialysis patients. The diagnosis of HCV infection in these patients is predominantly based on laboratory tests because of the specificity of the clinical course of the disease. AIM: The present prospective study aimed at determining very accurately the prevalence rate of HCV infection in patients on dialysis by simultaneously testing them for anti-HCV and for HCV RNA levels. MATERIALS AND METHODS: For the present cross-sectional longitudinal study we recruited and followed up 93 patients from St George University Hospital Hemodialysis Unit between July 2013 and December 2014...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384105/effect-of-training-at-lactate-threshold-intensity-on-maximal-time-to-exhaustion-depression-and-anxiety-behaviour-of-spontaneously-hypertensive-rats-after-kainate-induced-status-epilepticus
#12
Katerina N Georgieva, Margarita S Hadjieva, Mihaela S Shishmanova-Doseva, Dora D Terzieva, Nikola G Georgiev, Georgi G Andreev, Jana D Tchekalarova
AIM: The objective of the present study was to investigate the effect of treadmill training at lactate threshold intensity on maximum time to exhaustion (MTE) and heart rate (HR) as well as behavioral changes after kainate (KA)-induced status epilepticus (SE) of spontaneously hypertensive rats (SHRs). MATERIALS AND METHODS: Male SHRs were divided in four groups: two sedentary (vehicle- and KA-treated) and two exercised (vehicle- and KA-treated), respectively. The exercised rats were trained on a treadmill at a speed of 20 m...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384104/development-of-bioethics-and-clinical-ethics-in-bulgaria
#13
Silviya S Aleksandrova-Yankulovska
BACKGROUND: Bioethics and clinical ethics emerged from the classical medical ethics in the 1970s of the 20th century. Both fields are new for the Bulgarian academic tradition. AIM: The aims of this paper were to demarcate the subject fields of medical ethics, bioethics, and clinical ethics, to present the developments in the field of medical ethics in Bulgaria, to delineate the obstacles to effective ethics education of medical professionals, and to present the results of the application of an adapted bottom-up methodology for clinical ethics consultation in several clinical units in Bulgaria...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384103/emulsion-of-chloramphenicol-an-overwhelming-approach-for-ocular-delivery
#14
Kalpesh C Ashara, Ketan V Shah
BACKGROUND: Ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity. AIM: The present study aimed at exploring the impact of different oil mixtures in the form of emulsion on the permeability of chloramphenicol after ocular application. MATERIALS AND METHODS: Selection of oil mixture and ratio of the components was made by an equilibrium solubility method. An emulsifier was chosen according to its emulsification properties...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28384102/anatomic-variation-of-the-median-nerve-associated-with-an-anomalous-muscle-of-the-forearm
#15
Atoni Dogood Atoni, Charles Aidemise Oyinbo
Documented anatomical variations are important not only for the study of the subject of anatomy, but also in clinical situation. This knowledge would aid surgeons in planning a preoperative strategy for surgical procedures and reconstructive surgery. The right forearm of a 35-year-old embalmed male cadaver present a splitting of the median nerve in the proximal 1/3 of the forearm to form medial and lateral divisions that accommodate an anomalous muscle. The split median nerve reunites at the distal 1/3 and continues as a single nerve...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28068286/pathobiochemical-mechanisms-relating-iron-homeostasis-to-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#16
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies, and DAS 28...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28068285/vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose
#17
Silvia M Gancheva, Maria D Zhelyazkova-Savova
BACKGROUND: The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as a factor predisposing to the development of depression, anxiety and cognitive impairment in humans. AIM: In the present study we examined the effects of vitamin K2 on the behavior of rats with metabolic syndrome and looked for relationships with the effects on blood sugar. MATERIALS AND METHODS: Male Wistar rats were divided in four groups: a control group on a regular rat chow, a metabolic syndrome (MS) group fed a high-fat high-fructose diet, a control group treated with vitamin K2 and a MS group treated with vitamin K2...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28068284/adaptation-and-validation-of-a-burnout-inventory-in-a-survey-of-the-staff-of-a-correctional-institution-in-bulgaria
#18
Stanislava N Harizanova, Nonka G Mateva, Tanya Ch Tarnovska
BACKGROUND: Burnout syndrome is a phenomenon that seems to be studied globally in relation to all types of populations. The staff in the system of correctional institutions in Bulgaria, however, is oddly left out of this tendency. There is no standardized model in Bulgaria that can be used to detect possible susceptibility to professional burnout. The methods available at present only register the irreversible changes that have already set in the functioning of the individual. V. Boyko's method for burnout assessment allows clinicians to use individual approach to patients and affords easy comparability of results with data from other psychodiagnostic instruments...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28068283/association-between-noise-pollution-and-prevalent-ischemic-heart-disease
#19
Angel M Dzhambov, Donka D Dimitrova
BACKGROUND: Noise pollution is considered a risk factor for ischemic heart disease (IHD). Both are highly prevalent in Bulgaria, but their association has not been studied sufficiently. AIM: The aim of the present study was to examine the risk of IHD associated with road traffic (Lden) and lifetime occupational noise exposure (LONE) in a Bulgarian sample. MATERIALS AND METHODS: A cross-sectional survey was carried out among 513 residents of Plovdiv, Bulgaria...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28068282/serological-and-molecular-biological-studies-of-parvovirus-b19-coxsackie-b-viruses-and-adenoviruses-as-potential-cardiotropic-viruses-in-bulgaria
#20
Stefka Kr Ivanova, Svetla G Angelova, Asya P Stoyanova, Irina L Georgieva, Lubomira K Nikolaeva-Glomb, Zafira G Mihneva, Neli St Korsun
BACKGROUND: Inflammatory diseases of the heart (myocarditis, pericarditis) are commonly caused by viruses. Among the human cardiotropic viruses, parvovirus B19, Coxsackie B viruses, and adenoviruses play a leading role. AIM: The aim of the present study was to determine the presumptive causative role of parvovirus B19, Coxsackie B viruses, and adenoviruses in the development of myocarditis, pericarditis and dilated cardiomyopathy by demonstrating the presence of specific antiviral antibodies or viral DNA in patients' serum samples...
December 1, 2016: Folia Medica
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