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Seminars in Arthritis and Rheumatism

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https://www.readbyqxmd.com/read/28320529/prevalence-of-neuropathic-pain-in-knee-or-hip-osteoarthritis-a-systematic-review-and-meta-analysis
#1
REVIEW
Helen P French, Keith M Smart, Frank Doyle
OBJECTIVE: Discordance between radiographic and pain severity in osteoarthritis (OA) has led researchers to investigate other pain mechanisms, including neuropathic pain. Accurate identification of any neuropathic pain in hip or knee OA is important for appropriate management, but neuropathic pain prevalence is unknown. We aimed to obtain an overall prevalence estimate by systematically reviewing and meta-analysing the prevalence of neuropathic pain in people with hip or knee OA. METHOD: Observational studies which measured neuropathic pain in people aged 18 years and older with hip or knee OA were considered for inclusion...
February 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28284845/risks-of-malignancies-related-to-tofacitinib-and-biological-drugs-in-rheumatoid-arthritis-systematic-review-meta-analysis-and-network-meta-analysis
#2
José Ramón Maneiro, Alejandro Souto, Juan J Gomez-Reino
OBJECTIVE: To summarize and compare the risks of malignancies accompanying biologic DMARDs (b-DMARDs) and tofacitinib in rheumatoid arthritis (RA) in randomized clinical trials (RCTs) and long-term extension studies (LTEs). METHODS: Articles in Medline, Embase, Cochrane Library, and the Web of Science dated from 2000 to February 2015. Selection criteria were as follows: (1) focus on RCTs or LTEs in RA; (2) treatment with b-DMARDs or tofacitinib; (3) data on malignancies; and (4) a minimum follow-up of 12 weeks...
February 16, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28291582/sequential-nailfold-videocapillaroscopy-examinations-have-responsiveness-to-detect-organ-progression-in-systemic-sclerosis
#3
Jérôme Avouac, Gemma Lepri, Vanessa Smith, Elide Toniolo, Charlotte Hurabielle, Anaïs Vallet, Fazia Amrouche, André Kahan, Maurizio Cutolo, Yannick Allanore
OBJECTIVE: To determine the merit of nailfold videocapillaroscopy (NVC) to detect meaningful microvascular changes over time in patients with systemic sclerosis (SSc) and whether these changes are associated with overall disease progression and organ involvements. METHODS: A prospective cohort of 140 SSc patients was recruited over a 12-month period and was followed up on an annual basis for 3 years. Detailed NVC analysis was performed at inclusion and repeated annually...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28284844/investigating-methotrexate-toxicity-within-a-randomized-double-blinded-placebo-controlled-trial-rationale-and-design-of-the-cardiovascular-inflammation-reduction-trial-adverse-events-cirt-ae-study
#4
Jeffrey A Sparks, Medha Barbhaiya, Elizabeth W Karlson, Susan Y Ritter, Soumya Raychaudhuri, Cassandra C Corrigan, Fengxin Lu, Jacob Selhub, Daniel I Chasman, Nina P Paynter, Paul M Ridker, Daniel H Solomon
BACKGROUND: The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use. Prior observational studies investigating LDM toxicity compared LDM to other active drugs. Prior placebo-controlled clinical trials of LDM in inflammatory conditions were not large enough to investigate toxicity. The Cardiovascular Inflammation Reduction Trial (CIRT) is an ongoing NIH-funded, randomized, double-blind, placebo-controlled trial of LDM in the secondary prevention of cardiovascular disease...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28274482/clinical-characteristics-of-patients-with-bone-sarcoidosis
#5
Ying Zhou, Elyse E Lower, Huiping Li, Yolanda Farhey, Robert P Baughman
OBJECTIVE: To assess the clinical features, diagnosis, and treatment of bone sarcoidosis in the United States. METHODS: Patients with bone sarcoidosis were identified and matched to sarcoidosis patients based on race, gender, and age. Detailed characteristics were obtained by medical record review. RESULTS: A total of 64 patients with bone sarcoidosis were enrolled in this study. The female:male ratio was 1.46:1 and the white:black ratio was 3:1...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28274481/no-detection-of-varicella-zoster-virus-in-temporal-arteries-of-patients-with-giant-cell-arteritis
#6
Francesco Muratore, Stefania Croci, Ione Tamagnini, Alessandro Zerbini, Salvatore Bellafiore, Lucia Belloni, Luigi Boiardi, Alessandra Bisagni, Nicolò Pipitone, Maria Parmeggiani, Alberto Cavazza, Carlo Salvarani
OBJECTIVE: Data on the presence of varicella-zoster virus (VZV) in temporal arteries of patients with giant cell arteritis (GCA) are controversial. We analyzed VZV infection in temporal arteries from Italian patients with temporal artery biopsy (TAB)-positive GCA, TAB-negative GCA, and controls. METHODS: A total of 79 formalin-fixed, paraffin-embedded (FFPE) TABs performed between 2009 and 2012 at a single institution from 34 TAB-positive GCA patients, 15 TAB-negative GCA patients, and 30 controls were retrieved...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28325471/can-we-identify-who-gets-benefit-or-harm-from-mycophenolate-mofetil-in-systemic-lupus-erythematosus-a-systematic-review
#7
Claudia Mendoza-Pinto, Carmelo Pirone, Daniëlle A van der Windt, Ben Parker, Ian N Bruce
OBJECTIVES: We aimed to summarize the evidence examining factors that predict differential response to mycophenolate mofetil (MMF) in systemic lupus erythematosus (SLE). METHODS: Systematic searches of randomized clinical trials (RCT) to identify predictors of the effects of MMF (moderators), and cohort studies to explore prognostic factors associated with MMF outcomes (response, relapse, or adverse events) were performed. Two reviewers independently assessed the methodological quality of RCTs using the Cochrane Collaboration risk of bias tool and cohort studies using the QUality In Prognosis Studies tool...
February 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28268026/in-hospital-mortality-in-febrile-lupus-patients-based-on-2016-eular-acr-printo-classification-criteria-for-macrophage-activation-syndrome
#8
Sung Soo Ahn, Byung-Woo Yoo, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
OBJECTIVE: To evaluate the clinical significance of the 2016 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR)/Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria for macrophage activation syndrome (MAS) in patients with febrile systemic lupus erythematosus (SLE). METHODS: We performed a retrospective analysis of SLE patients with fever, who were admitted to Severance Hospital between December 2005 and May 2016...
February 8, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28291583/factors-predictive-of-high-disease-activity-early-in-the-course-of-sle-in-patients-from-a-latin-american-cohort
#9
Victor R Pimentel-Quiroz, Manuel F Ugarte-Gil, Guillermo J Pons-Estel, Enrique R Soriano, Verónica Saurit, Emilia I Sato, Lilian T Lavras Costallat, José Fernando Molina, Antonio Iglesias-Gamarra, Gil Reyes-Llerena, Oscar J Neira, Leonor A Barile, Luis H Silveira, María Ines Segami, Rosa Chacón-Díaz, Daniel Wojdyla, Graciela S Alarcón, Bernardo A Pons-Estel
AIMS: To determine the factors predictive of disease activity early in the course of SLE (baseline visit). METHODS: Patients from GLADEL, a multi-national, multi-ethnic, Latin-American lupus cohort were included. Disease activity was evaluated at baseline with the SLEDAI score. Demographic characteristics (age at diagnosis, gender, ethnicity, marital status, educational level, medical coverage and socioeconomic status) were assessed. Disease duration was defined as the time between the fourth ACR criterion and baseline...
February 2, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28233572/clinical-association-between-kikuchi-s-disease-and-systemic-lupus-erythematosus-a-systematic-literature-review
#10
REVIEW
Bernardo Sopeña, Alberto Rivera, Antonio Chamorro, Mayka Freire, Vanessa Alende, Elena Seco, Miguel A González-Gay, Arturo González-Quintela
OBJECTIVE: To perform a systematic review of all cases of the association between Kikuchi's disease (KD) and systemic lupus erythematosus (SLE), and to ascertain the clinical and laboratory characteristics of this association (KD-SLE). METHODS: We conducted a systematic search of the scientific literature until 31 January 2016. For study purposes, only patients aged >14 years, with histologically proven KD, definite SLE and adequate clinical data were included...
January 29, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28259425/incidence-associated-factors-and-clinical-impact-of-severe-infections-in-a-large-multicentric-cohort-of-patients-with-systemic-lupus-erythematosus
#11
Íñigo Rúa-Figueroa, Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Víctor Del Campo, Alejandro Olivé-Marqués, Sabina Pérez-Vicente, Antonio Fernández-Nebro, Mariano Andrés, Celia Erausquin, Eva Tomero, Loreto Horcada, Esther Uriarte, Mercedes Freire, Carlos Montilla, Ana Sánchez-Atrio, Gregorio Santos, Alina Boteanu, Elvira Díez-Álvarez, Javier Narváez, Víctor Martínez-Taboada, Lucía Silva-Fernández, Esther Ruiz-Lucea, José Luis Andreu, José Ángel Hernández-Beriain, Marian Gantes, Blanca Hernández-Cruz, José Pérez-Venegas, Ángela Pecondón-Español, Carlos Marras, Mónica Ibáñez-Barceló, Gema Bonilla, Vicente Torrente, Iván Castellví, Juan José Alegre, Joan Calvet, Jose Luis Marenco, Enrique Raya, Tomás Vázquez, Victor Quevedo, Santiago Muñoz-Fernández, Manuel Rodríguez-Gómez, Jesús Ibáñez, José M Pego-Reigosa
OBJECTIVES: To estimate the incidence of severe infection and investigate the associated factors and clinical impact in a large systemic lupus erythematosus (SLE) retrospective cohort. METHODS: All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria were retrospectively investigated for severe infections. Patients with and without infections were compared in terms of SLE severity, damage, comorbidities, and demographic characteristics...
January 27, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28285723/epigenetic-aspects-of-rheumatoid-arthritis-contribution-of-non-coding-rnas
#12
REVIEW
Bogdan Kolarz, Maria Majdan
Since microRNA was discovered in the late 1990s the role of non-coding RNAs in the regulation of cellular processes has been confirmed. Intensive researches have revealed a number of subtypes of non-coding RNA. It has been proved that these molecules can influence each step of the development of cells and tissues. Moreover, researchers have found their expression change during disease development. In this article, we gathered the current results on the contribution of microRNA and long non-coding RNA in rheumatoid arthritis pathogenesis and their potential use in rheumatoid arthritis treatment...
January 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28258768/quality-assessment-of-websites-providing-educational-content-for-patients-with-rheumatoid-arthritis
#13
Harish Rajashekarappa Siddhanamatha, Eric Heung, Maria de Los Angeles Lopez-Olivo, Noha Abdel-Wahab, Ana Ojeda-Prias, Irmgard Willcockson, Amye Leong, Maria Eugenia Suarez-Almazor
OBJECTIVE: We performed an environmental scan of currently available websites providing educational information about rheumatoid arthritis (RA) and evaluated the quality of these websites. METHODS: We searched three separate search engines, Google, Bing, and Ask.com, on August 27, 2015, using two search terms, "arthritis" and "rheumatoid." Only patient education websites were included. Two independent investigators evaluated the accuracy, completeness, technical elements, design and esthetics, readability, usability, and accessibility of the websites...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28216195/golimumab-in-real-life-settings-2-years-drug-survival-and-predictors-of-clinical-outcomes-in-rheumatoid-arthritis-spondyloarthritis-and-psoriatic-arthritis
#14
Florenzo Iannone, Leonardo Santo, Maria Grazia Anelli, Romano Bucci, Angelo Semeraro, Laura Quarta, Francesca D'Onofrio, Antonio Marsico, Giorgio Carlino, Oriana Casilli, Fabio Cacciapaglia, Carmelo Zuccaro, Paola Chiara Falappone, Francesco Paolo Cantatore, Maurizio Muratore, Giovanni Lapadula
OBJECTIVES: To assess the drug survival of golimumab, and predictors thereof, in patients affected with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) in a prospective observational cohort. METHODS: This is a non-interventional, longitudinal study on RA, SpA, and PsA patients starting treatment with golimumab. Endpoints were the 2 years persistence rate of golimumab and predictors of therapy discontinuation. Drug retention was analyzed using Kaplan-Meier and Cox models...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28216194/safety-of-resuming-biologic-dmards-in-patients-who-develop-tuberculosis-after-anti-tnf-treatment
#15
Soo-Kyung Cho, Dam Kim, Soyoung Won, Minkyung Han, Jiyoung Lee, Eun Jin Jang, Tae-Hyung Kim, Sang-Cheol Bae, Yoon-Kyoung Sung
OBJECTIVES: To estimate the incidence of tuberculosis (TB) in rheumatoid arthritis (RA) patients treated with tumor necrotizing factor inhibitor (TNFI) and evaluate the safety of resuming biologic disease-modifying anti-rheumatic drugs (DMARDs) in patients who developed TB after anti-TNF treatment. METHODS: We conducted an inception cohort study of RA patients in the Korean Healthcare Claims Database who started TNFI as the first biologic DMARD between January 2009 and December 2013...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28216193/frequency-of-concomitant-fibromyalgia-in-rheumatic-diseases-monocentric-study-of-691-patients
#16
Angelique Fan, Bruno Pereira, Anne Tournadre, Zuzana Tatar, Sandrine Malochet-Guinamand, Sylvain Mathieu, Marion Couderc, Martin Soubrier, Jean-Jacques Dubost
OBJECTIVE: Fibromyalgia (FM) is a confounding factor for diagnosing and assessing rheumatic disease activity. This study sought to assess the extent of this syndrome in rheumatism patients at a French rheumatology department. METHOD: This monocentric epidemiological study enrolled all patients consulting due to rheumatoid arthritis (RA), spondyloarthritis (SpA), or connective tissue disease (CTD). FM diagnosis was confirmed or excluded according to the rheumatologist opinion and the 1990 American College of Rheumatology (ACR) criteria...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28216192/does-expert-opinion-match-the-operational-definition-of-the-lupus-low-disease-activity-state-lldas-a-case-based-construct-validity-study
#17
Vera Golder, Molla Huq, Kate Franklyn, Alicia Calderone, Aisha Lateef, Chak Sing Lau, Alfred Lok Hang Lee, Sandra Teresa V Navarra, Timothy Godfrey, Shereen Oon, Alberta Yik Bun Hoi, Eric Francis Morand, Mandana Nikpour
OBJECTIVE: To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). METHODS: Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international rheumatologists with expertise in SLE, but with no prior involvement in the LLDAS project, responded to a survey in which they were asked to categorize the disease activity state of each case as remission, low, moderate, or high...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28196621/psoriatic-arthritis-disease-activity-during-pregnancy-and-the-first-year-postpartum
#18
Ari Polachek, Suzanne Li, Inbal Shlomi Polachek, Vinod Chandran, Dafna Gladman
OBJECTIVES: To evaluate disease activity in the joints and skin during pregnancy and the first-year postpartum in patients with psoriatic arthritis (PsA). METHODS: Women with PsA who were pregnant between 1990 and 2015 with at least 1 clinic visit during pregnancy were identified from the Toronto PsA database. The course of joint and skin disease activity was defined by the following 5 states: improvement, worsening, stable low, stable high, or a mixed. As controls, 67 nonpregnant PsA women were identified and evaluated over a similar timeframe...
January 16, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28214014/controlling-the-digital-ulcerative-disease-in-systemic-sclerosis-is-associated-with-improved-hand-function
#19
Luc Mouthon, Patrick H Carpentier, Catherine Lok, Pierre Clerson, Virginie Gressin, Eric Hachulla, Alice Bérezné, Elisabeth Diot, Aurélie Khau Van Kien, Patrick Jego, Christian Agard, Anne-Bénédicte Duval-Modeste, Agnès Sparsa, Eve Puzenat, Marie-Aleth Richard
OBJECTIVES: Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan. METHODS: ECLIPSE (Study AC-052-517) is a 2-year prospective, multicenter, and observational study. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan were included between October 2009 and March 2011...
January 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28040245/the-rising-prevalence-and-incidence-of-gout-in-british-columbia-canada-population-based-trends-from-2000-to-2012
#20
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Kam Shojania, Eric C Sayre, Hyon K Choi
OBJECTIVES: Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available. We estimated the prevalence, incidence, prescription patterns, and comorbidity burden of gout in an entire Canadian province [British Columbia (BC)] over the last decade. METHODS: We utilized PopulationData BC, a province-wide database, to estimate temporal trends in the prevalence and incidence of gout from 2000 to 2012, as well as according to age category...
February 2017: Seminars in Arthritis and Rheumatism
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