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Seminars in Arthritis and Rheumatism

Gabriela Schmajuk, Kashif Jafri, Michael Evans, Stephen Shiboski, Milena Gianfrancesco, Zara Izadi, Sarah L Patterson, Ishita Aggarwal, Urmimala Sarkar, R Adams Dudley, Jinoos Yazdany
INTRODUCTION/OBJECTIVES: Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal opportunistic infection; however, consensus varies around which conditions or medications confer a level of risk sufficient to justify antibiotic prophylaxis for PJP. We used electronic health record (EHR) data to assess the current patterns of PJP prophylaxis, PJP outcomes, and prophylaxis-related adverse events among patients with rheumatic diseases who were receiving high-risk immunosuppressant drugs...
November 3, 2018: Seminars in Arthritis and Rheumatism
Jiacai Cho, Jamie Zhou, Dominic Lo, Anselm Mak, Sen Hee Tay
OBJECTIVES: To determine the extent of end-of-life suffering and predictors of high symptom prevalence in the last one year of life in patients with systemic rheumatic diseases (SRDs) and the extent of supportive care received. METHODS: We identified adult patients with SRDs who died between 1 April 2006 and 1 April 2016. We collected data within 1 year before their death, on the following: (i) cumulative symptom prevalence, (ii) rates of Advance Care Planning (ACP), Do-Not-Resuscitate (DNR) orders and referral to a palliative physician...
November 2, 2018: Seminars in Arthritis and Rheumatism
Paul Rj Ames, Mira Merashli, Tommaso Bucci, Fabrizio Gentile, Jose Delgado-Alves
OBJECTIVE: To evaluate the effect of antiphospholipid antibodies (aPL) on renal allograft outcome after kidney transplantation. METHODS: A systematic search of EMBASE and PubMed databases from inception to July 2018 was run according to PRISMA guidelines; Peto's odds ratio (OR) for rare events was used for the meta-analysis. RESULTS: Our inclusion/exclusion criteria were met by 22 cohort studies having different outcomes: allograft thrombosis (n = 9) and thromboprophylaxis (n = 3), allograft loss from any cause (n = 9), allograft malfunction (n = 3), duration (n = 2), glomerular filtration rate at 1 year (n = 3) and allograft rejection (n = 5)...
October 19, 2018: Seminars in Arthritis and Rheumatism
Brandon L Adler, Catherine J Wang, Thanh-Lan Bui, Hannah M Schilperoort, April W Armstrong
BACKGROUND: Though anti-tumor necrosis factor agents (anti-TNFs) have been recommended as third-line therapy for sarcoidosis, an up-to-date systematic synthesis of their efficacy and safety is lacking. OBJECTIVES: To systematically review the literature to characterize the efficacy and safety of anti-TNFs in sarcoidosis. SETTINGS: All countries and treatment settings were included. METHODS: We searched MEDLINE, EMBASE, CINAHL, Web of Science, ClinicalTrials...
October 16, 2018: Seminars in Arthritis and Rheumatism
Gil Amarilyo, Gabriel Chodick, Jonathan Zalcman, Gideon Koren, Yoel Levinsky, Ido Somekh, Liora Harel
OBJECTIVE: Recurrent episodes of acute rheumatic fever may contribute to the development or worsening of rheumatic heart disease. Secondary penicillin prophylaxis (SPP) has been found to significantly reduce the incidence of rheumatic heart disease. This study sought to evaluate adherence to oral and intramuscular SPP in pediatric patients with rheumatic fever using real-world data spanning 10 years. METHODS: The study population included patients <18 years old insured by a 2...
October 16, 2018: Seminars in Arthritis and Rheumatism
Konstantinos Tselios, Dafna D Gladman, Murray B Urowitz
BACKGROUND: In recent years, low disease activity emerged as a state that is associated with improved long-term outcomes in systemic lupus erythematosus (SLE). Our aim was to review the current concepts for low disease activity in SLE in order to serve as the basis of a future consensus for standardization. METHODS: The PubMed database was searched for relevant articles from inception up to July 2018. Medical Subject Headings (MeSH terms) included "lupus" AND "low disease activity" OR "minimal disease activity"...
October 16, 2018: Seminars in Arthritis and Rheumatism
Meghan J Mooradian, Mazen Nasrallah, Justin F Gainor, Kerry L Reynolds, Justine V Cohen, Donald P Lawrence, Eli M Miloslavsky, Minna J Kohler, Ryan J Sullivan, Sara R Schoenfeld
BACKGROUND: The use of immune checkpoint inhibition (ICI) has revolutionized cancer treatment. However, these medications are associated with significant and potentially debilitating immune-related adverse events (irAEs). While certain toxicities have been well studied, rheumatic complications have been less widely recognized and characterized. METHODS: We report our experience of patients who were evaluated by rheumatology after the development of a suspected rheumatic irAE following ICI treatment...
October 16, 2018: Seminars in Arthritis and Rheumatism
Ans Van Ginckel, Michelle Hall, Fiona Dobson, Patrick Calders
OBJECTIVE: To investigate effects of long-term exercise therapy for people with knee osteoarthritis (OA) on radiographic disease severity and cartilage integrity (primary outcomes) as well as severity of bone marrow lesions (BMLs), synovitis and/or effusion (secondary outcomes). METHODS: We sourced randomized controlled trials in people with clinical and/or radiographic OA investigating the effect of land-based exercise therapy of > 6 months on radiographic disease severity and magnetic resonance imaging outcomes of cartilage integrity (morphology or composition) as well as BML, synovitis and/or effusion severity, when compared to no exercise...
October 16, 2018: Seminars in Arthritis and Rheumatism
Sonya Abraham, Anne Barton, Lihi Eder, Adrian Lim, Dennis McGonagle, Neil McHugh, Stephen Pennington, Raj Sengupta, Stefan Siebert, Paul Bowness, Peter H Schafer, Eva Cullen, Oliver FitzGerald
No abstract text is available yet for this article.
October 15, 2018: Seminars in Arthritis and Rheumatism
Lazaros I Sakkas, Dimitrios Daoussis, Athanasios Mavropoulos, Stamatis-Nick Liossis, Dimitrios P Bogdanos
OBJECTIVE: Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing autoimmune diseases. The aim of the study was to review the literature related to Bregs in autoimmune rheumatic diseases (ARDs). METHODS: A literature review of publications in PUBMED published in English was performed using the relevant combinations of terms...
October 15, 2018: Seminars in Arthritis and Rheumatism
Abdelhafeez Moshrif, Jean Denis Laredo, Hassan Bassiouni, Mohamed Abdelkareem, Pascal Richette, Matthieu Reshe Rigon, Thomas Bardin
BACKGROUND: Calcium pyrophosphate dihydrate deposition disease (CPPD) has been reported to involve the spine, but few systematic studies have been published. OBJECTIVE: To further characterize the spinal involvement with CPPD by a review of CPPD patients hospitalized in a rheumatology department. METHODS: We retrospectively reviewed data for patients consecutively admitted with a diagnosis of CPPD in the rheumatology department of Lariboisière hospital in Paris, France over 5 years by using a standardized protocol and electronic case report forms...
October 14, 2018: Seminars in Arthritis and Rheumatism
Amber Young, Vivek Nagaraja, Mark Basilious, Mirette Habib, Whitney Townsend, Heather Gladue, David Badesch, J Simon R Gibbs, Deepa Gopalan, Alessandra Manes, Ronald Oudiz, Toru Satoh, Adam Torbicki, Fernando Torres, Vallerie McLaughlin, Dinesh Khanna
OBJECTIVE: Pulmonary arterial hypertension (PAH) has high morbidity and mortality in connective tissue diseases (CTDs), especially systemic sclerosis (SSc). In this systematic review, we provide an update on screening measures for early detection of PAH in CTD. METHODS: Manuscripts published between July 2012 and October 2017, which incorporated screening measures to identify patients with PAH by right heart catheterization, were identified. Risk of bias was assessed using the QUADAS-2 tool...
October 14, 2018: Seminars in Arthritis and Rheumatism
N Champtiaux, V Cottin, G Chassagnon, B Chaigne, D Valeyre, H Nunes, E Hachulla, D Launay, B Crestani, C Cazalets, P Jego, G Bussone, A Bérezné, L Guillevin, M P Revel, J F Cordier, L Mouthon
BACKGROUND: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) primarily due to tobacco smoking has been reported in connective tissue disease, but little is known about its characteristics in systemic sclerosis (SSc). METHODS: In this retrospective multi-center case-control study, we identified 36 SSc patients with CPFE, and compared them with 72 SSc controls with interstitial lung disease (ILD) without emphysema. RESULTS: Rate of CPFE in SSc patients with CT scan was 3...
October 13, 2018: Seminars in Arthritis and Rheumatism
Francesco Muratore, Filippo Crescentini, Lucia Spaggiari, Giulia Pazzola, Massimiliano Casali, Luigi Boiardi, Nicolò Pipitone, Stefania Croci, Galli Elena, Raffaella Aldigeri, Annibale Versari, Carlo Salvarani
OBJECTIVE: To evaluate aortic diameter and predictors of aortic dilatation using 18 FDG-PET/CT in a longitudinally followed cohort of patients with large vessel vasculitis (LVV) compared with controls. METHODS: All consecutive patients with LVV who underwent at least 2 PET/CT scans between January 2008 and May 2015 were included. The first and last PET/CT study was evaluated by a radiologist and a nuclear medicine physician. Diameter and FDG uptake of the aorta was measured at 4 different levels: ascending, descending thoracic, suprarenal and infrarenal abdominal aorta...
October 12, 2018: Seminars in Arthritis and Rheumatism
Jocelyn Quistrebert, Signe Hässler, Delphine Bachelet, Cyprien Mbogning, Anne Musters, Paul Peter Tak, Carla Ann Wijbrandts, Marieke Herenius, Sytske Anne Bergstra, Gülşah Akdemir, Martina Johannesson, Bernard Combe, Bruno Fautrel, Sylvie Chollet-Martin, Aude Gleizes, Naoimh Donnellan, Florian Deisenhammer, Julie Davidson, Agnès Hincelin-Mery, Pierre Dönnes, Anna Fogdell-Hahn, Niek De Vries, Tom Huizinga, Imad Abugessaisa, Saedis Saevarsdottir, Salima Hacein-Bey-Abina, Marc Pallardy, Philippe Broët, Xavier Mariette
OBJECTIVES: To evaluate the incidence of anti-drug antibody (ADA) occurrences and ADA-related risk factors under adalimumab and infliximab treatment in rheumatoid arthritis (RA) patients. METHODS: The study combined retrospective cohorts from the ABIRISK project totaling 366 RA patients treated with adalimumab (n = 240) or infliximab (n = 126), 92.4% of them anti-TNF naive (n = 328/355) and 96.6% of them co-treated with methotrexate (n = 341/353) with up to 18 months follow-up...
October 12, 2018: Seminars in Arthritis and Rheumatism
Yvette C Cozier, Medha Barbhaiya, Nelsy Castro-Webb, Carolyn Conte, Sara Tedeschi, Cianna Leatherwood, Karen H Costenbader, Lynn Rosenberg
BACKGROUND: Obesity may influence systemic lupus erythematous (SLE) pathogenesis via stimulation of systemic inflammation, but the relationship between obesity and SLE risk is unclear. Past studies have predominantly assessed White women, while Black women have higher prevalence of both obesity and SLE. METHODS: We prospectively assessed the relationship between Body Mass Index (BMI, kg/m2 ) and incident SLE within the Black Women's Health Study (median age 38 at entry in 1995)...
October 11, 2018: Seminars in Arthritis and Rheumatism
Simon Tarp, Tanja S Jørgensen, Daniel E Furst, Anna Dossing, Peter C Taylor, Ernest H Choy, Maria E Suarez-Almazor, Anne Lyddiatt, Lars E Kristensen, Henning Bliddal, Robin Christensen
OBJECTIVES: To assess the efficacy and safety of methotrexate (MTX) in combination with an approved biological agent compared to biological monotherapy, in the management of patients with rheumatoid arthritis (RA). METHODS: MEDLINE, EMBASE, CENTRAL and other sources were searched for randomised trials evaluating a biological agent plus MTX versus the same biological agent in monotherapy. Co-primary outcomes were ACR50 and the number of patients who discontinued due to adverse events (AEs)...
October 9, 2018: Seminars in Arthritis and Rheumatism
Terese R Gullo, Yvonne M Golightly, Rebecca J Cleveland, Jordan B Renner, Leigh F Callahan, Joanne M Jordan, Virginia B Kraus, Amanda E Nelson
BACKGROUND/PURPOSE: To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort. METHODS: Following PRISMA guidelines and with the help of a professional research librarian, we performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, and multi-joint among others, to obtain articles related to MJOA. A total of 42 articles were included for data extraction based on multiple criteria including the requirement for a clearly stated definition of OA assessed at more than one body site...
October 9, 2018: Seminars in Arthritis and Rheumatism
Fiona Rayner, John D Isaacs
Experimental immune tolerance induction, enabling tissues to be transplanted across animal strains, was first demonstrated in the 1950s. Therapeutic tolerance induction, whereby immune tolerance is used to treat or prevent transplant rejection, and as a treatment for autoimmunity, followed in the 1980s. Clinical translation has been slow but the pace of change is accelerating. Numerous strategies are now being tested clinically, ranging from monoclonal antibodies against T-cells, to peptide therapies, cellular therapies and microbiome manipulation...
September 28, 2018: Seminars in Arthritis and Rheumatism
Antoine Grillon, Marc Scherlinger, Pierre-Hugues Boyer, Sylvie De Martino, Aleth Perdriger, Amandine Blasquez, Julien Wipff, Anne-Sophie Korganow, Christian Bonnard, Alain Cantagrel, Didier Eyer, François Guérin, Irène Monteiro, Jean-Marie Woehl, Paul Moreau, Jean-Loup Pennaforte, Joel Lechevallier, Frédéric Bastides, Antoine Colombey, Isabelle Imbert, Yves Maugars, Philippe Gicquel, François Cuchet, Michel Brax, Jean Sibilia, Laurence Zilliox, Cathy Barthel, Laurent Arnaud, Benoit Jaulhac
OBJECTIVES: To describe the clinical and microbiological characteristics and outcomes after antibiotic treatment of a national cohort of patients with Lyme arthritis confirmed by PCR testing on synovial fluid and by serology, when available. METHODS: Using the French National Reference Center for Borrelia database, patients with a positive PCR on synovial fluid for Borrelia were identified. Patient clinical and biological characteristics were reviewed from patient records...
September 28, 2018: Seminars in Arthritis and Rheumatism
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