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Seminars in Arthritis and Rheumatism

Mohammad Hassan A Noureldine, Wared Nour-Eldine, Munther A Khamashta, Imad Uthman
The Antiphospholipid syndrome (APS), formerly known as Anticardiolipin or Hughes syndrome, is a systemic autoimmune disorder characterized by obstetrical complications and thrombotic events affecting almost every organ-system in patients persistently testing positive for antiphospholipid antibodies (aPL). The contribution of the extra-criteria aPL to the pathogenesis of APS have exceeded the expectations of a simple, direct pathologic 'hit' leading to thrombogenesis or obstetrical complications, and more pathologic pathways are being linked directly or indirectly to aPL...
August 23, 2018: Seminars in Arthritis and Rheumatism
Kathryn Connelly, Julian Segan, Alicia Lu, Meher Saini, Flavia M Cicuttini, Louisa Chou, Andrew M Briggs, Kaye Sullivan, Maheeka Seneviwickrama, Anita E Wluka
OBJECTIVES: To identify the breadth of the literature regarding patients' perceived health information needs related to inflammatory arthritis care. METHODS: A systematic scoping review of MEDLINE, EMBASE, CINAHL and PsycINFO was performed to identify relevant articles (1990 -2016) examining patients' perceived needs relating to health information in inflammatory arthritis. Data and themes were identified and categorised and risk of bias assessed. RESULTS: Twenty nine studies (11 quantitative, 14 qualitative and 4 mixed methods) from 4121 identified articles were relevant for inclusion...
August 18, 2018: Seminars in Arthritis and Rheumatism
Maria Mouyis, Julia D Flint, Ian P Giles
There is limited evidence relating to the impact of disease modifying anti-rheumatic drugs (DMARDs) upon male fertility and peri-conception paternal exposure in men with rheumatic disease. Therefore, we conducted a systematic review of available evidence to update information on this subject and guide paternal counselling. A systematic search of PubMed and Embase was carried out up to September 2017, to find relevant peer-reviewed papers, using keywords for fertility/spermatogenesis/conception, men, and disease modifying or biologic drugs commonly prescribed in patients with rheumatic disease...
August 17, 2018: Seminars in Arthritis and Rheumatism
Michael Hughes, John D Pauling
Digital ulcers are common in patients with systemic sclerosis, affecting over half of patients during the course of their disease. For some patients, digital ulcers occur as isolated phenomena; whereas, for others, digital ulceration is recurrent, and often refractory to intervention. Demonstrating treatment efficacy for digital ulcer disease has typically focussed on clinician opinion of ulcer healing and new ulcer occurrence. Advances in management have improved outcomes which may have had the unfortunate effect of rendering traditional trial endpoints less effective at demonstrating treatment efficacy...
August 11, 2018: Seminars in Arthritis and Rheumatism
Luna Gargani, Cosimo Bruni, Tatiana Barskova, Valentina Hartwig, Martina Marinelli, Maria Giovanna Trivella, Marco Matucci-Cerinic, Antonio L'Abbate
OBJECTIVES: Systemic sclerosis (SSc) causes functional and structural microcirculatory dysfunction, affecting also distal extremities. Optical Near-InfraRed Spectroscopy (NIRS) of blood HbO2 saturation (stO2 ) is able to evaluate O2 delivery/consumption balance in the explored tissue. The NIRS-sensitive camera non-invasively detects stO2 values in superficial tissues, automatically generating 2D-imaging maps in real time. We aimed at testing whether NIRS hand imaging may evaluate peripheral microcirculatory dysfunction and its spatial heterogeneity in SSc patients compared to controls...
August 11, 2018: Seminars in Arthritis and Rheumatism
Sarah Stewart, Angela Brenton-Rule, Nicola Dalbeth, Ashok Aiyer, Christopher Frampton, Keith Rome
OBJECTIVE: To determine characteristics of the foot and ankle in people with systemic lupus erythematosus (SLE). METHODS: Medline, CINAHL, Sports-Discus, Scopus and Cochrane Library databases were searched up to January 2018. Studies reporting foot- and ankle-related outcomes in the following domains were included: vascular, neurological, musculoskeletal, cutaneous (skin and nail) or pain/function. The Quality Index tool was used to assess methodological quality...
August 6, 2018: Seminars in Arthritis and Rheumatism
Anaïs Dartevel, Benjamin Chaigne, Laurence Moachon, Florian Grenier, Nicolas Dupin, Loïc Guillevin, Laurence Bouillet, Luc Mouthon
OBJECTIVE: To characterize levamisole-induced vasculopathy. METHODS: We performed a systematic review searching MEDLINE for articles published from 1972 to 2016. RESULTS: We retrieved 357 references and abstracts and selected 111 articles. Levamisole-induced vasculopathy was reported in 192 patients, with a female predominance (n = 122, 63.5%). Median [interquartile range] age was 44 [38-50]. Skin was the most frequently involved organ (n = 182, 94...
August 1, 2018: Seminars in Arthritis and Rheumatism
Medha Barbhaiya, Candace H Feldman, Hongshu Guan, Sarah K Chen, Michael A Fischer, Daniel H Solomon, Brendan M Everett, Karen H Costenbader
OBJECTIVE: Systemic lupus erythematosus (SLE), which is associated with increased stroke risk, is more prevalent and often more severe among Blacks, Asians, and Hispanics than Whites. We examined racial/ethnic variation in stroke rates and risks, overall and by hemorrhagic versus ischemic subtype, among SLE patients. METHODS: Within Medicaid (2000-2010), we identified patients aged 18-65 with SLE (≥ 3 ICD-9 710.0 codes, ≥ 30 days apart) and ≥12 months of continuous enrollment...
July 31, 2018: Seminars in Arthritis and Rheumatism
Deepan S Dalal, Josefina Duran, Tina Brar, Rasha Alqadi, Christopher Halladay, Alisha Lakhani, James L Rudolph
OBJECTIVE: Biologic anti-rheumatic drugs are used with less frequency among older patients compared to young patients. This population is less represented in studies performed to evaluate the efficacy and safety of this drugs. We aimed to assess the efficacy and safety of biological agents between the older RA patients compared to young. METHODS: A comprehensive, systematic search was conducted in major indexing databases using key terms for RA and each biological agent...
July 31, 2018: Seminars in Arthritis and Rheumatism
M T Sanchez-Santos, A Judge, M Gulati, T D Spector, D J Hart, J L Newton, N K Arden, S Kluzek
OBJECTIVE: It is unclear whether the association between osteoarthritis (OA) and metabolic syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim was to describe the association between MetS and radiographic OA (ROA) affecting the knee or the hand in the presence or absence of concurrent joint pain. METHODS: Cross-sectional data of 952 women, aged 45-65 years from the Chingford study, a population-based longitudinal cohort of middle-aged women initiated in 1988-1989 in London (UK), was analysed...
July 31, 2018: Seminars in Arthritis and Rheumatism
Laura Ross, David Prior, Susanna Proudman, Alessandra Vacca, Murray Baron, Mandana Nikpour
BACKGROUND: Clinically evident primary heart involvement due to systemic sclerosis (SHI) is considered a poor prognostic factor and is a leading cause of systemic sclerosis (SSc) related death. Yet, there remains no consensus definition of SHI and poor understanding of the natural history and risk factors for the development of SHI. METHODS: We performed a scoping literature review of published articles with a primary focus of SHI to capture previously used definitions of SHI and items used to measure SHI...
July 31, 2018: Seminars in Arthritis and Rheumatism
Sandra Mara Meireles, Anamaria Jones, Jamil Natour
OBJECTIVE: investigating the effectiveness of orthosis for rhizarthrosis by means of a systematic review and meta-analysis. METHODS: A systematic review was carried out using eight electronic databases. The randomized controlled trials included were those presenting subjects using orthosis for rhizarthrosis compared with individuals without orthosis or other rehabilitation interventions, as well as studies that compared different types of orthosis. The systematic review was performed according to the Cochrane methodology...
July 31, 2018: Seminars in Arthritis and Rheumatism
Gina Hetland Brinkmann, Vibeke Norvang, Ellen Sauar Norli, Lars Grøvle, Anne Julsrud Haugen, Åse Stavland Lexberg, Erik Rødevand, Gunnstein Bakland, Halvor Nygaard, Frode Krøll, Inger Johanne Widding-Hansen, Olav Bjørneboe, Cathrine Thunem, Tore Kvien, Maria Dahl Mjaavatten, Elisabeth Lie
OBJECTIVE: To assess the 2-year effect on disease activity and health-related quality of life (HRQoL) of implementing a clinical practice treat-to-target (T2T) strategy in patients with rheumatoid arthritis (RA). METHODS: Patients in the Norwegian Very Early Arthritis Cohort 2.0 (NOR-VEAC 2.0), included 2010-2015, were treated according to T2T principles with visits at baseline, 3, 6, 9, 12 months, then every 6 months plus monthly visits until DAS28 <2.6. These patients were compared to a pre-T2T cohort of patients included in the Norwegian Disease Modifying Anti-Rheumatic Drug (NOR-DMARD) register 2006-2009...
July 25, 2018: Seminars in Arthritis and Rheumatism
Marc Scherlinger, Emmanuel Langlois, Vincent Germain, Thierry Schaeverbeke
OBJECTIVE: To study acceptance rate and factors influencing acceptance of the switch from originator etanercept (Enbrel©) to biosimilar etanercept (SB4, Bénépali©) in patients with rheumatic disease. METHODS: Patients with a well-controlled rheumatic disease consulting in our rheumatology department were offered the switch for SB4. After oral and written information concerning biosimilar, free choice to accept the switch was left to the patients. The main outcome was primary switch acceptance rate defined by switch acceptance during the initial consult...
July 20, 2018: Seminars in Arthritis and Rheumatism
Alan J Kivitz, Stanley Cohen, Edward Keystone, Ronald F van Vollenhoven, Boulos Haraoui, Jeffrey Kaine, Haiyun Fan, Carol A Connell, Eustratios Bananis, Liza Takiya, Roy Fleischmann
OBJECTIVE: This post-hoc, pooled analysis of Phase 3 studies of tofacitinib examined the safety of tofacitinib 5 and 10 mg twice daily (BID) when used as monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in patients with rheumatoid arthritis (RA). METHODS: Pooled data from six double-blind, randomized controlled Phase 3 studies of tofacitinib 5 and 10 mg BID in patients with RA were analyzed for safety and stratified by administration as monotherapy (ORAL Solo: NCT00814307 and ORAL Start: NCT01039688) or in combination with csDMARDs (ORAL Sync: NCT00856544, ORAL Standard: NCT00853385, ORAL Scan: NCT00847613, and ORAL Step: NCT00960440), and by glucocorticoid use at baseline...
July 19, 2018: Seminars in Arthritis and Rheumatism
Linda Kimsey, Joel S Weissman, Avni Patel, Allison Drew, Tracey Koehlmoos, Jeffrey A Sparks
OBJECTIVE: To investigate factors associated with delay in initiation of initial disease-modifying antirheumatic drug (DMARD) in patients newly diagnosed with rheumatoid arthritis (RA). METHODS: We performed a retrospective cohort descriptive study using administrative data from the US military's TRICARE program (2007-2012). We identified incident RA cases using billing codes and initial DMARD receipt using prescription fill date. We quantified the time between RA presentation and initial DMARD receipt, evaluated temporal changes in delay over the study period, and investigated predictors of treatment delay (> 90 days) using logistic regression...
July 18, 2018: Seminars in Arthritis and Rheumatism
David N Brennan, Patompong Ungprasert, Kenneth J Warrington, Matthew J Koster
OBJECTIVES: To investigate the association between smoking and giant cell arteritis (GCA). METHODS: A systematic review was performed and meta-analysis conducted on observational studies that reported absolute numbers and/or statistical comparisons with 95% confidence intervals comparing smoking history and presence of GCA, among patients with GCA and non-GCA controls. Studies were reviewed in accordance with PRISMA guidelines. Point estimates and standard errors were extracted from individual studies and were combined by the generic inverse variance method of DerSimonian and Laird...
July 11, 2018: Seminars in Arthritis and Rheumatism
Alvise Berti, Divi Cornec, Jose R Medina Inojosa, Eric L Matteson, M Hassan Murad
BACKGROUND: To better communicate the results of randomized controlled trials (RCTs) of giant cell arteritis (GCA), we propose the use of the fragility index (FI), which is an intuitive measure defined as the minimum number of subjects whose status would have to change (e.g., from having the outcome to not) to render a statistically significant result nonsignificant, or vice-versa. METHODS: We conducted a systematic review and random-effects meta-analysis of RCTs of glucocorticoid (GC) sparing strategies for relapse-free maintenance in GCA, and used the FI to simplify the presentation of results...
August 2018: Seminars in Arthritis and Rheumatism
Parvaneh Heidari, Wendy Cross, Kimberley Crawford
INTRODUCTION: For individuals with a chronic condition, long-term management of their medication can be difficult and as a result non-adherence is common among this cohort. In patients with rheumatoid arthritis (RA), the introduction of biologic agents was a revolutionary treatment but the high costs of this medication might limit their utilisation. OBJECTIVE: This systematic review aimed to determine whether out-of-pocket (OOP) costs affect adherence to RA medications in adults with a diagnosis of RA...
August 2018: Seminars in Arthritis and Rheumatism
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, entheses, enthesitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, monitoring, and/or diagnosis of enthesitis in PsA, or if they discussed clinical or imaging indices used to assess enthesitis...
August 2018: Seminars in Arthritis and Rheumatism
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