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Seminars in Arthritis and Rheumatism

Dam Kim, Jeongim Choi, Soo-Kyung Cho, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo, Sang-Cheol Bae, Yoon-Kyoung Sung
OBJECTIVE: To identify the clinical characteristics of diffuse alveolar hemorrhage (DAH) compared to other types of acute diffuse lung infiltration in SLE patients, and the factors associated with mortality in these patients. METHODS: We studied a retrospective cohort including SLE patients with acute diffuse lung infiltration on thoracic CT between January 2004 and August 2014. We divided them into 2 groups, a DAH and a non-DAH group, and compared the clinical characteristics and outcomes in the 2 groups...
September 14, 2016: Seminars in Arthritis and Rheumatism
Rille Pullerits, Hanna Schierbeck, Karin Uibo, Hille Liivamägi, Sirje Tarraste, Tiina Talvik, Erik Sundberg, Chris Pruunsild
OBJECTIVE: High mobility group box protein 1 (HMGB1) is an important pro-inflammatory mediator in adult rheumatoid arthritis. The diagnostic utility of HMGB1 in Juvenile Idiopathic Arthritis (JIA) is still unclear. The aim was to examine whether serum HMGB1 levels are associated with inflammation, radiological disease progression, and long-term prognosis in JIA. METHODS: We included 131 children with JIA from a population-based prevalence study; 38 of them were prospectively followed up for 10 years...
August 26, 2016: Seminars in Arthritis and Rheumatism
Felix Eckstein, Robert Buck, Wolfgang Wirth
OBJECTIVE: The metric accepted by regulatory bodies for determining structural progression in clinical trials of knee osteoarthritis (OA) remains change in radiographic joint space width in the medial femorotibial compartment. However, magnetic resonance imaging has revealed that cartilage loss is spatially heterogeneous, and that it is enigmatic which knee will lose cartilage at which location. Whereas previous reviews have focused on imaging in general, the purpose of this particular perspective is to highlight availability and applications of location-independent analysis methodology in measuring structural progression in epidemiological and interventional clinical trials, and to highlight its specific advantages over existing methodologies...
August 26, 2016: Seminars in Arthritis and Rheumatism
David J Gazeley, Supraja Yeturi, Payal J Patel, Ann K Rosenthal
BACKGROUND: Erosive osteoarthritis (EOA) is a commonly invoked diagnosis representing an important variant of hand osteoarthritis (OA). There is increasing literature on the prevalence, risk factors, etiology, and management of EOA. METHODS: We systematically reviewed the literature to assess variability in the diagnostic definitions used to define EOA in these studies. RESULTS: We reviewed 336 articles and found 62 articles citing diagnostic definitions for EOA...
August 24, 2016: Seminars in Arthritis and Rheumatism
Elizabeth Salt, Amanda T Wiggins, Mary Kay Rayens, Brent J Morris, David Mannino, Andrew Hoellein, Ryan P Donegan, Leslie J Crofford
OBJECTIVE: Inconclusive findings about infection risks, importantly the use of immunosuppressive medications in patients who have undergone large-joint total joint arthroplasty, challenge efforts to provide evidence-based perioperative total joint arthroplasty recommendations to improve surgical outcomes. Thus, the aim of this study was to describe risk factors for developing a post-operative infection in patients undergoing TJA of a large joint (total hip arthroplasty, total knee arthroplasty, or total shoulder arthroplasty) by identifying clinical and demographic factors, including the use of high-risk medications (i...
August 24, 2016: Seminars in Arthritis and Rheumatism
Kalliopi Klavdianou, Stamatis-Nick Liossis, Lazaros Sakkas, Dimitrios Daoussis
BACKGROUND: Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology and fibrosis. OBJECTIVES: To provide an overview of our current knowledge of the role of Dkk-1 in joint remodeling and fibrosis. METHODS: We performed an electronic search (Medline) using the following key words: Dickkopf-1 (or Dkk-1), new bone formation, joint remodeling, ankylosing spondylitis, systemic sclerosis (or scleroderma), and fibrosis, supplemented by a manual search of references from retrieved articles...
August 23, 2016: Seminars in Arthritis and Rheumatism
David Bar-Or, Kristin Salottolo
No abstract text is available yet for this article.
August 18, 2016: Seminars in Arthritis and Rheumatism
Julie J Paik, Lisa Christopher-Stine
No abstract text is available yet for this article.
August 17, 2016: Seminars in Arthritis and Rheumatism
Carmelo Messina, Luca M Sconfienza
No abstract text is available yet for this article.
August 17, 2016: Seminars in Arthritis and Rheumatism
Su-Shin Lee, Hung-Pin Tu
No abstract text is available yet for this article.
August 17, 2016: Seminars in Arthritis and Rheumatism
Ui-Yoon Choi, Seung-Beom Han, Soo-Young Lee, Dae-Chul Jeong
No abstract text is available yet for this article.
August 17, 2016: Seminars in Arthritis and Rheumatism
Michelle Hall, Tim V Wrigley, Jessica Kasza, Fiona Dobson, Yong Hao Pua, Ben R Metcalf, Kim L Bennell
INTRODUCTION: This study aimed to evaluate associations between strength of selected hip and knee muscles and self-reported physical function, and their clinical relevance, in men and women with hip osteoarthritis (OA). METHODS: Cross-sectional data from 195 participants with symptomatic hip OA were used. Peak isometric torque of hip extensors, flexors, and abductors, and knee extensors were measured, along with physical function using the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire...
August 16, 2016: Seminars in Arthritis and Rheumatism
Christina Petsch, Elizabeth Araujo, Axel Hueber, Georg Schett, Bernhard Manger, Juergen Rech
No abstract text is available yet for this article.
August 16, 2016: Seminars in Arthritis and Rheumatism
Giacomo Emmi, Maria Letizia Urban, Antonella Scalera, Matteo Becatti, Claudia Fiorillo, Elena Silvestri, Domenico Prisco
No abstract text is available yet for this article.
August 12, 2016: Seminars in Arthritis and Rheumatism
Aurélien Guffroy, Benjamin Dervieux, Simon Gravier, Camille Martinez, Joelle Deibener-Kaminsky, Eric Hachulla, Marc Michel, Jean-Christophe Weber, Anne-Sophie Korganow, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Sibilia
OBJECTIVES: Systemic capillary leak syndrome (Clarkson's disease) is a rare entity characterized by recurrent and unpredictable attacks of capillary leakage of plasma fluid and proteins throughout the endothelium. Some cases are secondary. We describe the rare association between secondary capillary leak syndrome (SCLS) and autoimmune diseases. METHODS: We conducted a nationwide, retrospective, observational, and collaborative study throughout the hospital units of the Club des Rhumatismes et Inflammations network (CRI) between March and August 2015...
August 12, 2016: Seminars in Arthritis and Rheumatism
Sunita Paudyal, Frances M Yang, Christopher Rice, Chen-Chun Chen, Michael Skelton, Monique Bethel, Shilpa Brown, Norris Stanley Nahman, Laura Carbone
OBJECTIVES: To determine the frequency of end-stage renal disease (ESRD) in patients with rheumatoid arthritis (RA), the causes of ESRD, and the treatment of RA in the setting of ESRD. METHODS: Cross-sectional study of RA (N = 3754) and non-RA (N = 326,776) patients in the United States Renal Data System (USRDS) during 2011 (N = 330,530). The epidemiology of ESRD in RA was determined and the etiology of ESRD in patients with and without RA was compared. The frequency of patients with RA with at least one filled prescription for prednisone/prednisolone, a DMARD, and/or a biologic in 2011 was determined...
August 2, 2016: Seminars in Arthritis and Rheumatism
Fleischmann R, Landewé R, Smolen J S
OBJECTIVE: Treatment options available to patients with rheumatoid arthritis (RA) are ever-changing, and understanding the similarities and differences of efficacy and safety between different RA therapies is of key importance in order to facilitate treatment decisions by both the patient and physician. Very few head-to-head, peer-reviewed trials exist; instead, evidence for efficacy of treatments is often ascertained from placebo-controlled trials, registries and meta-analyses, which often do not sufficiently address the relative effectiveness of two medications...
August 1, 2016: Seminars in Arthritis and Rheumatism
Lisa Stamp, Nicola Dalbeth
OBJECTIVE: The observed associations of hyperuricaemia with hypertension, cardiovascular disease and kidney disease are receiving increasing interest. The potential role of urate-lowering therapy in the management of these "non-gout diseases" has been raised, and in some countries it is already recommended. However, there is no consistent definition of hyperuricaemia or asymptomatic hyperuricaemia, much remains unknown about the causal role of urate in these "non-gout diseases" and there is currently a lack of evidence about the effects of urate lowering on disease progression...
July 28, 2016: Seminars in Arthritis and Rheumatism
Sella A Provan, Inge C Olsen, Cathrine Austad, Glenn Haugeberg, Tore K Kvien, Till Uhlig
OBJECTIVE: To investigate whether osteoporosis or use of calcium supplementations predict all-cause mortality, or death from CVD, in a longitudinal cohort of patients with rheumatoid arthritis (RA). METHODS: Patients in the Oslo RA register (ORAR) were examined, and bone mineral density was measured in 1996. The cohort was linked to the Norwegian Cause of Death registry on December 31, 2010. Death from CVD was defined in 3 following different outcomes: (1) primary atherosclerotic death, (2) atherosclerotic death as one of the 5 listed causes of death, and (3) CVD according to World Health Organization (WHO) definition as primary cause of death...
July 26, 2016: Seminars in Arthritis and Rheumatism
Edward Yelin, Stuart Weinstein, Toby King
No abstract text is available yet for this article.
July 26, 2016: Seminars in Arthritis and Rheumatism
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