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Clinica Chimica Acta; International Journal of Clinical Chemistry

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https://www.readbyqxmd.com/read/29928865/prozone-like-phenomenon-found-in-chemiluminescent-enzyme-immunoassay-using-magnetic-particles-for-measurement-of-serum-anti-single-stranded-dna-antibody-titers-definition-and-management
#1
Takehiro Obara, Kazushi Toyomaki, Yurino Uegaki, Yoshie Kikuchi, Jiro Arai, Keiko Kuroda, Akira Suwabe
BACKGROUND: Serum anti-single stranded DNA antibody (anti-ssDNAab) is used as a marker for systemic lupus erythematosus. We found a 'prozone-like phenomenon,' which was different from an original prozone phenomenon, in chemiluminescent enzyme immunoassay using magnetic particles for the measurement of serum anti-ssDNAab titers. We investigated mechanisms of the prozone-like phenomenon and countermeasures to prevent it from being overlooked. METHODS: This study examined 679 samples from patients tested for anti-ssDNAab titer at our hospital...
June 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29908941/the-prognostic-value-of-preoperative-neutrophil-to-lymphocyte-ratio-in-patients-with-upper-tract-urothelial-carcinoma
#2
Ping Tan, Hang Xu, Liangren Liu, Jianzhong Ai, Huan Xu, Yong Jiang, Xiaoyu Zhang, Lu Yang, Qiang Wei
BACKGROUND: We evaluated the prognostic impact of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy treatment. METHODS: A total of 717 patients were identified between 2003 and 2016. The cutoff value of NLR was set as 2.5. Kaplan-Meier method and Cox's proportional hazards regression models were utilized to analyze the association between NLR and oncological outcomes. RESULTS: The median follow-up was 42 months...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29908940/a-nomogram-integrating-hepatic-reserve-and-tumor-characteristics-for-hepatocellular-carcinoma-following-curative-liver-resection
#3
Bin-Bin Cai, Ke-Qing Shi, Peng Li, Bi-Cheng Chen, Liang Shi, Philip J Johnson, Paul Lai, Hidenori Toyoda, Meng-Tao Zhou
BACKGROUND: Because of the mutual influence of liver dysfunction and malignancy, overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC). We developed a nomogram integrating albumin-bilirubin (ALBI) grade, a new index of hepatic reserve, and tumor characteristics of HCC for predicting OS following curative liver resection. METHODS: The nomogram was built to estimate the probabilities of 1, 3, and 5-y OS based on training cohort of 709 HCC, which was validated in an international independent dataset...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29906419/the-utility-of-long-non-coding-rna-zeb1-as1-as-a-prognostic-biomarker-in-human-solid-tumors-a-meta-analysis
#4
REVIEW
Xue-Liang Zuo, Juan Cai, Zhi-Qiang Chen, Yao Zhang, Lin-Hu Liang, Jun-Feng Wang, Jin-Guo Wang, Jian Wu, Jia-Ding Mao
PURPOSE: This meta-analysis aims to assess the prognostic value of long non-coding RNA ZEB1-AS1 in human solid tumors. METHODS: We searched the available databases up to January 2018. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of ZEB1-AS1 on patient survival. RESULTS: Eight eligible studies with a total of 586 patients were enrolled. A significant association was observed between ZEB1-AS1 overexpression and poor overall survival (OS; HR = 2...
June 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29906418/serum-gdnf-levels-and-anxiety-disorders-in-a-population-based-study-of-young-adults
#5
Fernanda Pedrotti Moreira, Carolina David Wiener, Karen Jansen, Luis Valmor Portela, Diogo R Lara, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Jean Pierre Oses
OBJECTIVE: The aim of this study was to verify the serum GDNF levels in individuals with anxiety disorder (AD) in a population-based study. METHODS: This was a cross-sectional study population-based, with people aged 18 to 35. AD's assessment was performed using the Mini International Neuropsychiatric Interview (M.I.N.I). Serum GDNF was measured by ELISA using a commercial kit. RESULTS: The prevalence was 3.3% for post-traumatic stress disorder, 6...
June 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29894782/assessing-the-stability-of-cd-mn-pb-se-and-total-hg-in-whole-human-blood-by-icp-drc-ms-as-a-function-of-temperature-and-time
#6
Denise S Tevis, Jeffery M Jarrett, Deanna R Jones, Po-Yung Cheng, Melanie Franklin, Neva Mullinex, Kathleen L Caldwell, Robert L Jones
BACKGROUND: Comprehensive information on the effect of time and temperature storage on the measurement of elements in human, whole blood (WB) by inductively coupled plasma-dynamic reaction cell-mass spectrometry (ICP-DRC-MS) is lacking, particularly for Mn and Se. METHODS: Human WB was spiked at 3 concentration levels, dispensed, and then stored at 5 different temperatures: -70 °C, -20 °C, 4 °C, 23 °C, and 37 °C. At 3 and 5 weeks, and at 2, 4, 6, 8, 10, 12, 36 months, samples were analyzed for Pb, Cd, Mn, Se and total Hg, using ICP-DRC-MS...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29894781/glycophagy-an-emerging-target-in-pathology
#7
REVIEW
Hong Zhao, Mingzhu Tang, Meiqing Liu, Linxi Chen
Autophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such as mitophagy, reticulophagy and glycophagy. Glycophagy, as a selective autophagy, plays a crucial role in maintaining glucose homeostasis in many tissues including heart, liver and skeletal muscles. Moreover, glycophagy is highly regulated by many signal pathways like the cyclic AMP protein kinase A/protein kinase A, PI3K-Akt/PKB-mTOR and Calcium...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29894780/the-rate-of-neonatal-respiratory-distress-syndrome-transient-tachypnea-in-the-newborn-and-the-amniotic-lamellar-body-count-in-twin-pregnancies-compared-with-singleton-pregnancies
#8
Hiroyuki Tsuda, Tomomi Kotani, Tomoko Nakano, Kenji Imai, Takafumi Ushida, Akihiro Hirakawa, Fumie Kinoshita, Yuichiro Takahashi, Shigenori Iwagaki, Fumitaka Kikkawa
BACKGROUND: Whether or not the period of fetal lung maturity differs between twin and singleton pregnancies has not been clarified. We examined whether or not fetal lung maturity and fetal lung absorption are achieved earlier in twin fetuses than in singleton fetuses. METHODS: We registered 454 singleton pregnancies and 398 twin pregnancies with no congenital abnormalities affecting the respiratory function or neonatal deaths. All patients were delivered by Caesarean section without labor between 24 and 38 gestational weeks...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29894779/mirna-221-222-in-thyroid-cancer-a-meta-analysis
#9
REVIEW
Ling Liang, Xucai Zheng, Mingjun Hu, Yanjie Cui, Qi Zhong, Shengying Wang, Fen Huang
OBJECTIVES: A meta-analysis was performed to observe whether a difference in miRNA-221/222 expression exists in thyroid cancer with normal thyroid or BTLs (benign thyroid lesions) and, under this premise, assess its diagnostic efficacy for thyroid cancer. METHODS: Systematic electronic literature searches were conducted to include PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science. The combined fold change (FC) was calculated, and pooled estimates of sensitivity, specificity, diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC) curves were calculated...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29890125/serum-uric-acid-and-metabolic-components-with-special-reference-to-diabetes-mellitus
#10
LETTER
Tomoyuki Kawada
No abstract text is available yet for this article.
June 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29885321/lncrna-zeb1-as1-expression-in-cancer-prognosis-review-and-meta-analysis
#11
REVIEW
Chunye Chen, Yan Feng, Xing Wang
BACKGROUNDS: Several studies have explored the prognostic value of long non-coding RNA ZEB1 antisense RNA 1 (lncRNA ZEB1-AS1) in various types of cancer. However, the role of lncRNA ZEB1-AS1 in cancer prognosis remains unclear. This study aimed to summarize the prognostic value of lncRNA ZEB1-AS1 in cancer. METHODS: PubMed, Web of Science, Embase and Cochrane Library were thoroughly searched. All relevant studies satisfying the inclusion criteria were enrolled. The endpoints used in this study included overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and various clinical parameters...
June 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29885320/objective-clinical-pain-analysis-using-serum-cyclooxygenase-2-and-inducible-nitric-oxide-synthase-in-american-patients
#12
Omowunmi A Sadik, Idris Yazgan, Orhan Eroglu, Peng Liu, Sarah T Olsen, Alecia M Moser, Phillip G Sander, Courage Tsiagbe, Kei Harada, Saeed Bajwa, Christian D Tvetenstrand, Lijun Yin, Peter Gerhardstein
BACKGROUND: Pain is a multidimensional condition of multiple origins. Determining both intensity and underlying cause are critical for effective management. Utilization of painkillers does not follow any guidelines relying on biomarkers, which effectively eliminates objective treatment. The aim of this study was to evaluate the use of serum cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as pain biomarkers. This work could significantly advance the diagnosis and treatment of pain...
June 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29885319/the-90-day-prognostic-value-of-serum-cyclophilin-a-in-traumatic-brain-injury
#13
Hang-Huang Jin, Tian-Ming Mao, Zhi-Qiang Bai, Yuan Chen, Hai-Long Ji, Yong Jin
BACKGROUND: Cyclophilin A is involved in many inflammatory diseases and its expression is up-regulated after brain injury. We determined if serum cyclophilin A could be used as a marker for severity and 90-day outcome in patients with traumatic brain injury (TBI). METHODS: Serum cyclophilin A concentrations were quantified in 105 severe TBI patients and 105 healthy individuals. Its association with Glasgow Coma Scale (GCS) score, 90-day mortality and 90-day poor outcome (Glasgow Outcome Scale score of 1-3) were investigated...
June 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29885318/independent-and-combined-effects-of-resting-heart-rate-and-pulse-pressure-with-metabolic-syndrome-in-chinese-rural-population-the-henan-rural-cohort-study
#14
Xia Zhang, Yuqian Li, Fang Wang, Jianguo Zang, Xiaotian Liu, Honglei Zhang, Kaili Yang, Gongyuan Zhang, Chongjian Wang
BACKGROUND: We examined the independent and cumulative associations of resting heart rate and pulse pressure with metabolic syndrome in Chinese rural population based on epidemiological research. METHODS: A total of 38,708 participants were derived from the Henan Rural Cohort study. Restricted cubic splines and logistic regression model were used to estimate the odds ratios and 95% confidence intervals of metabolic syndrome risk in relation to resting heart rate and pulse pressure...
June 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29883634/mir-139-in-digestive-system-tumor-diagnosis-and-detection-bioinformatics-and-meta-analysis
#15
REVIEW
Yu-Hui Wang, Jia Ji, Hong Weng, Bi-Cheng Wang, Fu-Bing Wang
BACKGROUND: Accumulating evidence has indicated that microRNAs play important roles in the initiation and progression of digestive system tumors. However, previous studies suggest that the accuracy of miRNA detection in digestive system tumors was inconsistent. METHODS: The candidate miRNAs were obtained from The Cancer Genome Atlas (TCGA). Meta-analysis was performed to evaluate the diagnostic value of these miRNAs in digestive system tumors. Furthermore, the potential target genes of the miRNAs were predicted and assessed with functional analysis...
June 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29883633/assessment-of-diagnostic-methods-for-the-detection-of-anticardiolipin-and-anti-%C3%AE-eta-2-glycoprotein-i-antibodies-in-patients-under-routine-evaluation-for-antiphospholipid-syndrome
#16
Thomas B Martins, Nahla Heikal, Jason Miller, Rohan Willis, Robert L Schmidt, Anne E Tebo
BACKGROUND: We assessed the performance characteristics and correlations of the traditional enzyme-linked immunosorbent assay (ELISA) and chemiluminescence immunoassay (CIA) for detecting IgG and IgM antibodies to cardiolipin (aCL) and beta2 glycoprotein (anti-β2 GPI) antibodies in patients under routine evaluation for APS. METHODS: Patients (n = 216) referred to ARUP Laboratories for lupus anticoagulant (LAC) and/or aCL or anti-β2 GPI IgG/IgM antibodies evaluation were assessed by ELISA and CIA methods...
June 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29883632/predictive-value-of-serum-cyclophilin-a-concentrations-after-acute-pancreatitis
#17
Guo-Wen Lu, De-Wen Lu, Yi-Xin Zhang
BACKGROUND: Cyclophilin A is identified as a biomarker for inflammation. We elucidated prognostic significance of serum cyclophilin A (CypA) concentrations in acute pancreatitis (AP). METHODS: In this prospective and observational study, serum CypA concentrations were quantified in 210 AP patients and 100 healthy controls. We recorded local complication, in-hospital mortality and organ failure. Disease severity was assessed using the traditional predictors, namely Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score and sequential organ failure assessment score...
June 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29883631/establishing-age-and-sex-dependent-upper-reference-limits-for-the-plasma-lipoprotein-a-in-a-chinese-health-check-up-population-and-according-to-its-relative-risk-of-primary-myocardial-infarction
#18
Feng-Mei Cui, Fang Fang, Yong-Ming He, Dong-Ping Cai, Jun He, Xiang-Jun Yang
BACKGROUND: Though lipoprotein (a) (Lp (a)) has been considered as a risk factor for coronary artery disease, there is a lack of cutoff values of Lp (a) for Chinese Han ethnicity. METHODS: We included 1 population for health check-ups. Lp (a) percentile distributions were analyzed and its cutoff for Chinese Han ethnicity was also proposed according to the its relative risk of myocardial infarction. RESULTS: Lp (a) distributions differed between sexes, and were highly skewed towards low concentrations with a long tail towards the highest ones...
June 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29879418/uric-acid-in-aortic-dissection-a-meta-analysis
#19
REVIEW
Xiaodong Li, Shanshan Jiang, Jiaan He, Nan Li, Yichuan Fan, Xingzhi Zhao, Xinhua Hu
BACKGROUND: Studies on the serum uric acid levels in patients with aortic dissection have yielded conflicting results. OBJECTIVE: To compare the difference in serum uric acid (SUA) levels between aortic dissection patients and controls by meta-analysis. METHODS: Electronic literature search was conducted in PubMed, Embase, CKNI, CBM, Wanfang, and VIP databases until January 31, 2018. All observational studies that investigated SUA levels in aortic dissection patients and controls were included...
June 4, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29870683/urinary-n-terminal-fragment-of-titin-is-a-marker-to-diagnose-muscular-dystrophy-in-patients-with-cardiomyopathy
#20
Akiomi Yoshihisa, Takatoyo Kiko, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi
The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e.g. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM)]. We measured and compared the U-TN/creatinine ratio (U-TN/Cr; pmol/mg/dl) in 278 control subjects and 331 patients with various cardiomyopathies (DCM, n = 199; sarcoidosis, n = 18; HCM, n = 86; amyloidosis, n = 15; Fabry disease, n = 6; MD, n = 7)...
June 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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