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Clinica Chimica Acta; International Journal of Clinical Chemistry

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https://www.readbyqxmd.com/read/29241048/impact-of-serum-albumin-levels-on-long-term-all-cause-cardiovascular-and-cardiac-mortality-in-patients-with-first-onset-acute-myocardial-infarction
#1
Ming Xia, Chi Zhang, Jian Gu, Jing Chen, Lin-Chi Wang, Yan Lu, Chun-Yan Huang, Yong-Ming He, Xiang-Jun Yang
BACKGROUND: To evaluate the association of serum albumin (SA) with long-term all-cause, cardiovascular, and cardiac mortality in patients with first-onset acute myocardial infarction (AMI). METHODS: The cohort study enrolled 2305 patients with first-onset AMI. The median follow-up was of 1088days (3years). Impacts of SA on long-time mortality after AMI were determined using multivariate Cox proportional hazard regression analysis with backward selection. RESULTS: The patients were divided into three categories by SA tertiles (≤3...
December 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29233774/spurious-intraoperative-pth-results-observed-with-2nd-but-not-with-3rd-generation-pth-assays
#2
Etienne Cavalier, Marie-Louise Schleck, Jean-Claude Souberbielle
We report here an interference that has been observed with 2nd generation PTH assays (PTH2), but not with 3rd generation PTH ones (PTH3), during PTH monitoring occurring in a surgical intervention for the resection of a parathyroid adenoma. The patient was cured and calcium levels returned to normal the next day, but PTH did not decrease with PTH2 whereas it decreased by 50% with PTH3 assays during the intervention. The reason is probably a PTH fragment released by the parathyroid gland during surgery. This fragment possesses the C-terminal part of the peptide but lacks the first amino-acids and may thus be considered as a member of the non-(1-84) PTH fragments family...
December 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29229463/circulating-epithelial-cells-as-potential-biomarkers-for-detection-of-recurrence-in-patients-of-papillary-thyroid-carcinoma-with-positive-serum-anti-thyroglobulin-antibody
#3
Yan-Rong Li, Ching-Ping Tseng, Hsueh-Ling Hsu, Hung-Chih Lin, Yi-An Chen, Szu-Tah Chen, Miaw-Jene Liou, Jen-Der Lin
BACKGROUND: Serum thyroglobulin (Tg) is not a reliable tumor marker for monitoring disease status after treatment in patients with papillary thyroid carcinoma (PTC) with positive anti-thyroglobulin antibody (TgAb). The aim of this study was to evaluate the clinical role of circulating epithelial cells (CECs) in PTC patients with positive serum TgAb and undetectable serum Tg. METHODS: A pilot study was performed to evaluate CECs in 25 PTC patients with positive serum TgAb and undetectable serum Tg...
December 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29224950/mrna-microrna-and-lncrna-as-novel-bladder-tumor-markers
#4
REVIEW
Edyta Wieczorek, Edyta Reszka
Early detection of bladder cancer (BC) is essential for improvement of the patient's prognosis and general survival rates. Current diagnostic methods are still limited, so new specific and cost-effective biomarkers are emerging as the noninvasive tools in treatment decisions in recurrent BC. Gene expression and epigenetic profile can be analysed using quantitative real-time-PCR (qRT-PCR) method in urine, blood and tissue. This review provides an update of recent findings on BC molecular profile as novel markers in diagnosis and prognosis of bladder tumors...
December 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29223766/developing-a-value-proposition-for-high-sensitive-troponin-testing
#5
Andrew St John, Louise Cullen, Paul Jülicher, Christopher P Price
Laboratories are looking for ways that they can identify and deliver value through their service rather than just provide high quality test results. One way to demonstrate value has been described in the form of a value proposition where the application of a laboratory test is described explicitly in terms of the process of care and the patient outcomes. We have applied this concept to the use of high sensitive troponin assays for the assessment of patients with suspected acute coronary syndrome. From a previously described framework we use a checklist to describe the various steps in the complete intervention or clinical pathway, demonstrating how the test should be used, highlighting key evidence in the literature that supports the intervention and list some of the measures which can be used to assess how well the intervention is being adopted and implemented...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29223765/prognostic-role-of-serum-total-cholesterol-and-high-density-lipoprotein-cholesterol-in-cancer-survivors-a-systematic-review-and-meta-analysis
#6
REVIEW
Pingting Zhou, Bo Li, Bin Liu, Tianrui Chen, Jianru Xiao
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29223764/hypoxia-induced-and-hif1%C3%AE-vegf-mediated-tight-junction-dysfunction-in-choriocarcinoma-cells-implications-for-preeclampsia
#7
Yuan Zhang, Hai-Jun Zhao, Xin-Ru Xia, Fei-Yang Diao, Xiang Ma, Jing Wang, Li Gao, Jie Liu, Chao Gao, Yu-Gui Cui, Jia-Yin Liu
INTRODUCTION: Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced TJ dysfunction in trophoblast cells and its possible involvement in PE pathophysiology. METHODS: Choriocarcinoma cells were grown in a monolayer and treated with cobalt chloride (CoCl2) to induce hypoxia...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29221927/st2-as-a-novel-prognostic-marker-in-end-stage-renal-disease-patients-on-hemodiafiltration
#8
Evgenija Homsak, Robert Ekart
BACKGROUND: Patients with end-stage renal disease (ESRD) are prone to severe heart failure (HF) and to several life-threatening events. Therefore, the ability to assess disease prognosis and the risk of short-term events or death is of great importance. The role of soluble ST2 (sST2) as a potential new prognostic marker in ESRD patients is not yet known. The aim of our study was to assess the prognostic value of sST2 in ESRD patients on hemodiafiltration (HDF) and compare it with NT-proBNP, an established prognostic marker for HF and renal disease...
December 5, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29221926/plasma-protein-profiling-of-patients-with-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-as-potential-precursor-lesions-of-pancreatic-cancer
#9
Maria Ilies, Praveen Kumar Sappa, Cristina Adela Iuga, Felicia Loghin, Manuela Gesell Salazar, Frank Ulrich Weiss, Georg Beyer, Markus M Lerch, Uwe Völker, Julia Mayerle, Elke Hammer
Efforts for the early diagnosis of the pancreatic ductal adenocarcinoma (PDAC) have recently been driven to one of the precursor lesions, namely intraductal papillary mucinous neoplasm of the pancreas (IPMN). Only a few studies have focused on IPMN molecular biology and its overall progression to cancer. Therefore, IPMN lacks comprehensive characterization which makes its clinical management controversial. In this study, we characterized plasma proteins in the presence of IPMNs in comparison to healthy controls, chronic pancreatitis, and PDAC by a proteomics approach using data-independent acquisition based mass spectrometry...
December 5, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29217429/association-of-platelet-count-with-sarcopenic-obesity-in-postmenopausal-women-a-nationwide-population-based-study
#10
Woo-Jin Park, Dong-Hyuk Jung, Ji-Won Lee, Jae-Yong Shim, Yu-Jin Kwon
OBJECTIVES: The aim of this study was to examine the relationship between platelet count and sarcopenic obesity in postmenopausal women. METHOD: This cross-sectional study was conducted using nationally representative data. A total of 2810 postmenopausal women who participated in the 2008-2011 Korea National Health and Nutritional Examination Survey were included in this study. Sarcopenic obesity was defined by a sarcopenia criterion and an obesity criterion. Platelet counts were divided into quartiles as follows: Q, 150-222; Q2, 223-257; Q3, 258-294, and Q4, 295-450 (103/μl)...
December 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29217428/clinical-significance-of-galnacylated-glycans-in-cholangiocarcinoma-values-for-diagnosis-and-prognosis
#11
Waraporn Saentaweesuk, Atit Silsirivanit, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Chawalit Pairojkul, Ubon Cha'on, Somsiri Indramanee, Somchai Pinlaor, Thidarut Boonmars, Norie Araki, Chaisiri Wongkham
Cancer cells exhibited the aberrant cancer-associated glycans that are potential biomarkers for diagnosis and monitoring of the cancer. In this study, Sophora japonica agglutinin (SJA) was used to detect SJA-specific N-acetylgalactosamine-associated glycans (SNAG) in liver tissues and sera from cholangiocarcinoma (CCA) patients. Whether SNAG could be the diagnostic and prognostic markers for CCA was evaluated. SJA-histochemistry revealed that SNAG was undetec2 in normal bile ducts but was highly expressed in hyperplastic/dysplastic bile ducts and CCA...
December 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29208372/different-calibrator-options-may-strongly-influence-the-trueness-of-serum-transferrin-measured-by-abbott-architect-systems
#12
LETTER
Sara Pasqualetti, Assunta Carnevale, Elena Aloisio, Alberto Dolci, Mauro Panteghini
No abstract text is available yet for this article.
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29208371/integrated-semi-targeted-metabolomics-analysis-reveals-distinct-metabolic-dysregulation-in-pleural-effusion-caused-by-tuberculosis-and-malignancy
#13
Nanying Che, Yan Ma, Huabin Ruan, Lina Xu, Xueying Wang, Xinting Yang, Xiaohui Liu
BACKGROUND: Tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) are the 2 most frequent causes of exudative pleural effusions (PEs). However, the clinical differentiation is challenging. METHODS: Metabolic signatures in pleural effusion from 156 patients were profiled. An integrated semi-targeted metabolomics platform was incorporated for high throughput metabolite identification and quantitation. In this platform, orbitrap based mass spectrometry with data dependent MS/MS acquisition was applied in the analysis...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29203428/calibration-by-commutable-control-materials-is-able-to-reduce-inter-method-differences-of-current-high-performance-methods-for-hba2
#14
Renata Paleari, Ferruccio Ceriotti, Cornelis L Harteveld, Marta Strollo, Greet Bakker-Verweij, Jeanet Ter Huurne, Sharda Bisoen, Andrea Mosca
BACKGROUND: Most of the current methods used for the determination of HbA2 seem not well aligned. A comparison among the best performing techniques and the commutability of some control materials currently available and under development has been evaluated. METHODS: Forty blood samples were analyzed in duplicate over two separate days by different HPLC and capillary electrophoresis systems. The commutabilities of different control materials (NIBSC WHO reagent, Bio-Rad Lyphochek, and home prepared lyophilized controls RP1-3) have been assessed by analyzing the controls in quadruplicate over two consecutive days together with the blood samples...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29203427/the-association-between-plasma-homocysteine-and-ambulatory-blood-pressure-variability-in-patients-with-untreated-hypertension
#15
Suhua Li, Jieming Zhu, Lin Wu, Long Peng, Yanting Luo, Yunyue Zhao, Ruimin Dong, Lin Chen, Xixiang Tang, Jinlai Liu
BACKGROUND: Both homocysteine (Hcy) and blood pressure variability (BPV) are independent predictors of stroke, however, their relationship is rarely evaluated before. This study aimed to investigate the association Hcy and ambulatory BPV in subjects with untreated primary hypertension. METHODS: A total of 252 eligible patients were recruited. Plasma Hcy was measured and 24-h ambulatory blood pressure monitoring was performed for each subject. The systolic and diastolic BPV values were calculated as the SD of individual blood pressure values during 24h, daytime and nighttime, and then stratified by the tertiles of Hcy concentration (T1 to T3)...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29203429/oxidative-stress-in-urea-cycle-disorders-findings-from-clinical-and-basic-research
#16
REVIEW
Belisa Parmeggiani, Carmen Regla Vargas
Inborn errors of metabolism (IEM) comprise a group of over 600 disorders, each with a specific metabolic impairment due to a genetic defect. Urea cycle disorders (UCD) are IEM that affect the nitrogen disposal system, leading to hyperammonemia and the accumulation of other toxic metabolites in tissues of affected patients. UCD arise from mutations in the genes coding any of the enzymes participating in the urea cycle, either directly or as regulators of this pathway, causing severe respiratory alkalosis. Considering that the exact mechanisms underlying the damage found in UCD, the purpose of this minireview is to obtain data and search for links between UCD and oxidative stress, a phenomenon common to several IEM...
December 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29198990/prognostic-and-clinicopathological-value-of-nanog-in-hepatocellular-carcinoma-a-meta-analysis
#17
REVIEW
Chaojie Liang, Kaitong Zhang, Hua Ge, Wei Li, Guangming Li, Jixiang Wu
BACKGROUND AND AIMS: Recently, studies indicate that Nanog is over-expressed in hepatocellular carcinoma (HCC); however, the relationship between Nanog expression and clinicopathological and prognostic value remains controversial. Therefore, we conducted a meta-analysis to explore the role of Nanog in HCC. METHODS: Articles were included from PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and the Chinese WanFang database. The relationships between Nanog expression, clinicopathological features, and survival rate were calculated...
December 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29198989/effect-of-creatinine-and-cystatin-c-measurement-variations-on-calculated-estimated-glomerular-filtration-rate-variations-and-the-theoretical-impact-on-kidney-disease-stage-classification-a-retrospective-study
#18
Dae-Hyun Ko, Sung Woo Lee, Jungwon Hyun, Hyun Soo Kim, Min-Jeong Park, Dong Hoon Shin
BACKGROUND: The estimated glomerular filtration rate (eGFR) is an important parameter in the management of patients with kidney diseases, yet eGFR quality goals are lacking. We examined the uncertainties in eGFR determinations and assessed their impact on patient classifications, aiming to set eGFR quality goals. METHODS: Adult patients undergoing creatinine concentration assessments at our hospital, between June 2014 and October 2016, were included (N=285,982)...
December 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29198992/cardiac-troponin-and-adverse-outcomes-in-atrial-fibrillation-a-meta-analysis
#19
REVIEW
Yichuan Fan, Xingzhi Zhao, Xiaodong Li, Nan Li, Xinhua Hu
BACKGROUND: The prognostic value of cardiac troponin elevation in atrial fibrillation (AF) is unclear. OBJECTIVE: To investigate the association of cardiac troponin elevation with adverse outcomes in AF by conducting a meta-analysis. METHODS: We systematically searched the PubMed and Embase databases until April 2017 for studies assessing the association of cardiac troponin-T (cTnT) or troponin-I (cTnI) elevation with adverse outcomes in AF...
November 30, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29198991/interleukin-23-receptor-polymorphism-rs10889677-a-c-in-ankylosing-spondylitis-meta-analysis-in-caucasian-and-asian-populations
#20
REVIEW
Renfang Han, Qing Xia, Shengqian Xu, Dazhi Fan, Faming Pan
BACKGROUND: The association between interleukin-23 receptor (IL23R) gene rs10889677 polymorphism and ankylosing spondylitis (AS) susceptibility was inconsistent in the recent literatures. A systematic review and meta-analysis was therefore performed. METHODS: Online electronic databases were searched for relevant studies published up to November 2017. Meta-analyses were performed for the comparisons of allele (A versus C) and multiple genetic models, including dominant, recessive, heterozygous, and homozygous models using fixed or random effects models...
November 30, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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