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Clinica Chimica Acta; International Journal of Clinical Chemistry

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https://www.readbyqxmd.com/read/29031454/a-new-plasma-biomarker-enhance-the-clinical-prediction-of-postoperative-acute-kidney-injury-in-patients-with-hepatocellular-carcinoma
#1
Xing Zhou, Liyu Wang, Guoliang Wang, Xiang Cheng, Shaobo Hu, Wenbo Ke, Min Li, Yong Zhang, Zifang Song, Qichang Zheng
BACKGROUND: The ratio of serum γ-glutamyl transferase (GGT) to alanine aminotransferase (ALT) (GGT/ALT) is a marker for evaluating effects to antivirotic treatment and a helpful predictive factor for the prognosis of Child-Pugh A hepatocellular carcinoma (HCC) patients after surgery. The relationship between the incidence of postoperative acute kidney injury (AKI) and preoperative GGT/ALT is studied in hepatectomized hepatitis B- or C- associated HCC patients. METHODS: A total of 253 hepatitis B or C virus-related HCC patients undergoing hepatectomy between September 2012 and August 2016 at our hospital were included in the retrospective study...
October 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29024618/association-of-serum-asymmetric-dimethylarginine-homocysteine-and-l-arginine-concentrations-during-early-pregnancy-with-hypertensive-disorders-of-pregnancy
#2
Ei Maruta, Jingwen Wang, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Kenji Imai, Seiji Sumigama, Yoshimitsu Niwa, Takashi Mitsui, Shigeru Yoshida, Mamoru Yamashita, Akihiro Nawa, Koji Tamakoshi, Hiroaki Kajiyama, Fumitaka Kikkawa
BACKGROUND: Our previous study suggested that a lower l-arginine level (<70μM) at early gestation is associated with hypertensive disorders of pregnancy (HDP). The maternal asymmetric dimethylarginine (ADMA) and homocysteine (Hcy) concentrations also have been reported to be increased in HDP. These molecules have a key role in metabolism of nitric oxide. The aim of this study is to determine the most useful predictor of HDP at early gestation. METHODS: The concentrations of ADMA and Hcy at each of three periods in normal pregnancy were determined, and the values compared between the normal pregnancy and HDP groups...
October 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29017768/analytical-comparison-of-three-different-versions-of-a-high-sensitivity-cardiac-troponin-i-assay-over-10years
#3
Peter A Kavsak, Andrew Worster, Stephen A Hill, Andrew R MacRae, Allan S Jaffe
BACKGROUND: Concerns have been raised on the long-term analytical performance of high-sensitivity cardiac troponin (hs-cTn) assays with respect to different reagent formulations, lots and instrumentation. Our goal for the present study was to compare three different versions of an hs-cTnI assay in two different study populations to evaluate if assay re-formulation over 10years has also affected the analytical results. METHODS: Beckman Coulter's CE marked hs-cTnI assay (Access hsTnI, 2017) was tested in 100 lithium heparin plasma samples first tested in 2007 with their prototype hs-cTnI assay and in 100 serum samples tested with their enhanced hs-cTnI assay in 2011 with comparison performed by Passing-Bablok regression...
October 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28987777/palestinian-arab-ethnicity-is-associated-with-an-adverse-metabolic-phenotype
#4
Ram Weiss, Hisham Nassar, Ronit Sinnreich, Wiessam Abu Ahmad, James Otvos, Jeremy D Kark
Urban-dwelling Palestinians have been shown to have higher cardiovascular morbidity and mortality and prevalence of diabetes than urban Israelis. Inflammation is implicated in the etiology of these conditions. We hypothesized that increased inflammatory activation, manifested as increased GlycA, a novel biomarker of global inflammation, would be evident in Palestinians. We compared GlycA concentrations between Palestinians and Israelis and assessed the associations of GlycA with anthropometric, health behavioral and clinical variables in a sample of 1674 Palestinians and Israelis aged 25-74, residing in Jerusalem...
October 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28987776/bile-acid-profiles-in-neonatal-intrahepatic-cholestasis-caused-by-citrin-deficiency
#5
Ching-Hsuan Yang, Chiung-Yu Chen, Yen-Yin Chou, Hung-Chih Chiu, Wei-Lun Tsai, Shu-Chu Shiesh
BACKGROUND: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is characterized by conjugated hyperbilirubinemia and increased plasma bile acid concentrations. However, the underlying mechanisms remain unclear. We established a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for simultaneously quantifying plasma bile acids and examined bile acid profiles in NICCD infants. METHODS: We measured 15 bile acids within 15min and found a wide linear range for individual bile acids...
October 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28986053/external-quality-assessment-program-on-urinary-dysmorphic-erythrocytes
#6
LETTER
José Antonio Tesser Poloni, Fernanda Pereira da Silva Carpeggiani, Isabel Antas Tavares da Silva, Janaína A de Oliveira, Juliana Barroso Tobler, Edmo M Saldanha, Liane N Rotta
No abstract text is available yet for this article.
October 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28986052/an-effective-algorithm-for-the-serological-diagnosis-of-idiopathic-inflammatory-myopathies-the-key-role-of-anti-ro52-antibodies
#7
M Infantino, M Manfredi, V Grossi, M Benucci, G Morozzi, E Tonutti, M Tampoia, N Bizzaro
BACKGROUND: Patients with suspected idiopathic inflammatory myopathies (IIM) are commonly tested for the presence of anti-nuclear antibodies (ANA) by indirect immunofluorescence (IIF) on HEp-2 cell substrates. However, ANA-IIF false negative tests may occur in IIM because some antigens, such as Jo1 and Ro52, may be scarcely expressed on HEp-2 cells. In addition, cytoplasmic staining is often not appropriately investigated by a specific antibody assay, leading to decreased clinical sensitivity of the ANA test...
October 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28982590/copeptin-in-heart-failure-review-and-meta-analysis
#8
REVIEW
Yao Zhong, Rui Wang, Lulu Yan, Man Lin, Xingling Liu, Tianhui You
BACKGROUND: The aim of this study was to explore the prognostic value of copeptin for predicting all-cause mortality in heart failure (HF). METHODS: PubMed, Embase and Cochrane databases were systematically searched to identify if a 2×2 contingency table could be constructed based on both the copeptin level and the all-cause mortality in patients diagnosed with HF. The characteristics of test performance were summarized using forest plots and summary receiver operating characteristic curves (SROC)...
October 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28982054/urinary-metabolic-phenotyping-of-mucopolysaccharidosis-type-i-combining-untargeted-and-targeted-strategies-with-data-modeling
#9
Abdellah Tebani, Isabelle Schmitz-Afonso, Lenaig Abily-Donval, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Anais Brassier, Pascale De Lonlay, Farid Zerimech, Frédéric M Vaz, Bruno J Gonzalez, Stephane Marret, Carlos Afonso, Soumeya Bekri
BACKGROUND: Application of metabolic phenotyping could expand the pathophysiological knowledge of mucopolysaccharidoses (MPS) and may reveal the comprehensive metabolic impairments in MPS. However, few studies applied this approach to MPS. METHODS: We applied targeted and untargeted metabolic profiling in urine samples obtained from a French cohort comprising 19 MPS I and 15 MPS I treated patients along with 66 controls. For that purpose, we used ultra-high-performance liquid chromatography combined with ion mobility and high-resolution mass spectrometry following a protocol designed for large-scale metabolomics studies regarding robustness and reproducibility...
October 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28974361/comparing-the-diagnostic-ability-of-inflammatory-markers-in-metabolic-syndrome
#10
Ge Meng, Qi Zhu, Junwei Shao, Qing Zhang, Li Liu, Hongmei Wu, Yang Xia, Xue Bao, Yeqing Gu, Honglei Wang, Hongbin Shi, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Guolin Wang, Kun Song, Yuntang Wu, Kaijun Niu
BACKGROUND: Chronic low-grade inflammation contributes to the pathogenesis of the metabolic syndrome (MetS). Although some studies have demonstrated that several standard inflammatory markers provide diagnostic value for MetS, few studies have compared the diagnostic ability of various inflammatory markers. We demonstrated the diagnostic ability of several inflammatory markers in detecting MetS. METHODS: Complement component 3 (C3), C4, high-sensitivity C-reactive protein (hs-CRP), leukocyte count, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio (NLR) concentrations were measured in 6312 participants living in Tianjin, China...
September 30, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28969987/comparison-of-lipoprotein-derived-indices-for-evaluating-cardio-metabolic-risk-factors-and-subclinical-organ-damage-in-middle-aged-chinese-adults
#11
Xia Cao, Dongliang Wang, Jiansong Zhou, Zhiheng Chen
BACKGROUND: High-density lipoprotein cholesterol (HDL-C) and related lipoprotein ratios were used to assess lipid atherogenesis or insulin resistance. However, which of these indices is superior remains controversial and could differ across ethnic groups. We evaluated the efficacy of HDL-C, and related lipoprotein ratios in identifying cardio-metabolic risk factors (CMRs) or preclinical organ damage among a health check-ups population in China. METHODS: We conducted a cross-sectional study of 17,596 Chinese adults aged 40-64years, who participated in annual health checkups in China...
September 29, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28969986/prenatal-and-early-diagnosis-of-chinese-3-m-syndrome-patients-with-novel-pathogenic-variants
#12
Xuyun Hu, Hongdou Li, Baoheng Gui, Yufei Xu, Jin Wang, Niu Li, Jiasun Su, Shujie Zhang, Yanning Song, Yi Wang, Jingsi Luo, Xin Fan, Jian Wang, Shaoke Chen, Chunxiu Gong, Yiping Shen
BACKGROUND: 3-M syndrome is a clinically recognizable yet under-diagnosed primordial growth retardation disorder. Molecular testing for CUL7, OBSL1 or CCDC8 genes can provide confirmed diagnosis for patients at prenatal or early age. So far, the clinical and molecular features of Chinese 3-M syndrome patients have not been reported. METHODS: In this article, the authors performed prenatal and early diagnosis of Chinese patients with 3-M syndrome by Next-Generation Sequencing...
September 29, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28965771/enhanced-expression-of-nlrp3-inflammasome-related-inflammation-in-peripheral-blood-mononuclear-cells-in-sj%C3%A3-gren-s-syndrome
#13
Seong-Kyu Kim, Jung-Yoon Choe, Geon Ho Lee
OBJECTIVE: The aim of this study was to identify the association of NLRP3 inflammasome-induced inflammation with disease activity and damage in Sjögren's syndrome. METHODS: A total of 33 female patients with Sjögren's syndrome and 34 sex- and age-matched, healthy controls were consecutively enrolled. The mRNA expression levels of NLRP3, ASC, caspase-1, interleukin-1β (IL-1β), and IL-18 in peripheral blood mononuclear cells (PBMCs) were measured, as well as serum IL-1β and IL-18 protein expression levels...
September 29, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28964833/the-prognostic-role-of-controlling-nutritional-status-scores-in-patients-with-solid-tumors
#14
REVIEW
Ruo-Fei Liang, Jun-Hong Li, Mao Li, Yuan Yang, Yan-Hui Liu
BACKGROUND: We conducted a meta-analysis to investigate the association between preoperative controlling nutritional status (CONUT) scores in various solid tumors and clinical outcomes. METHODS: Relevant studies published up to August 12, 2017 were identified using electronic databases, including PubMed, Embase, and Web of Science. The pooled hazard ratios (HR) and their corresponding 95% confidence intervals (CI) for overall survival (OS) and event-free survival (EFS) were calculated to explore the relationship between preoperative CONUT score and prognosis...
September 28, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28964832/nafl-screening-score-a-basic-score-identifying-ultrasound-diagnosed-non-alcoholic-fatty-liver
#15
Yu-Jie Zhou, Yi-Fan Zhou, Ji-Na Zheng, Wen-Yue Liu, Sven Van Poucke, Tian-Tian Zou, Dong-Chu Zhang, Shengrong Shen, Ke-Qing Shi, Xiao-Dong Wang, Ming-Hua Zheng
BACKGROUND: Several non-invasive diagnostic scores for non-alcoholic fatty liver (NAFL) have been developed, but the clinical application is limited because of their complexity. AIM: To develop and validate an easy-to-calculate scoring system to identify ultrasound-diagnosed NAFL. METHODS: 48,489 patients from 2 centers were included in this study. Multivariable logistic regression models were employed for model development. Ultrasonography was applied to diagnose NAFL...
September 28, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28964834/combined-use-of-serum-gamma-glutamyl-transferase-level-and-ultrasonography-improves-prediction-of-perinatal-outcomes-associated-with-preeclamptic-pregnancy
#16
Juan Wu, Wei Zhou, Quanhua Li, Rui Yuan, Hezhou Li, Shihong Cui
INTRODUCTION: Serum gamma glutamyl transferase (GGT), produced and released mostly from the liver and bile duct, is an enzyme involved in response to oxidative stress, and has been used as a maker for prediction of cardiovascular events. Umbilical artery blood flow resistance index, e.g., the systolic/diastolic ratio (S/D ratio) as determined by ultrasound, has been used to assess the fetal intrauterine conditions. While changes of GGT and S/D ratio in preeclampsia are found to be associated with the risk for adverse perinatal outcome, the potential value of combined use of the two measurements for the prediction of adverse perinatal outcome has not been determined...
September 27, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28947355/serum-transforming-growth-factor-beta1-level-for-knee-osteoarthritis-diagnosis
#17
LETTER
Guo-Ming Zhang, Gao-Ming Zhang, Bing Gu
No abstract text is available yet for this article.
September 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28939099/prognostic-and-clinical-significance-of-vegfr-3-in-gastric-cancer-a-meta-analysis
#18
REVIEW
Hua Ge, Yan Yan, Lingfei Guo, Xueyan He, Xianzhi Yang
BACKGROUND: Recent studies have suggested that VEGFR-3 is involved in the development of gastric cancer, however, the results are contradictory. Hence, we conducted a meta-analysis to assess the correlation between VEGFR-3 and the clinicopathological characteristics of gastric cancer to assess its prognostic value. METHODS: An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, and Chinese CNKI. Correlations between VEGFR-3 expression and clinicopathological features and survival outcomes were analyzed...
September 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28917507/a-facile-gold-nanoparticle-based-elisa-system-for-detection-of-osteopontin-in-saliva-towards-oral-cancer-diagnostics
#19
Debolina Chakraborty, Thangaraj Soundara Viveka, Krishnamurthy Arvind, Vidyarani Shyamsundar, Murhekar Kanchan, Sruthi Ann Alex, N Chandrasekaran, Ramshankar Vijayalakshmi, Amitava Mukherjee
In the current study, we emphasize that osteopontin is overexpressed in oral squamous cell carcinoma. Overexpression of osteopontin levels was confirmed by mRNA quantification studies and immunohistochemistry analysis. Based on this, a gold nanoparticle-based ELISA system was developed for non-invasive osteopontin detection. The incorporation of AuNRs (Gold nanorods) or AuNSs (Gold nanospheres) in the conventional ELISA improved the sensitivity of analyses. A considerably lowered detection limit in case of AuNR (detection limit: 0...
September 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28818597/is-there-a-j-shaped-relationship-between-the-fatty-liver-index-and-risk-of-microalbuminuria-in-the-general-population
#20
Jong Wook Choi, Il Hwan Oh, Chang Hwa Lee, Joon-Sung Park
BACKGROUND: We investigated whether the fatty liver index (FLI), as a clinical indicator of hepatic fat accumulation based on body mass index, gamma-glutamyl-transferase, triglycerides, and waist circumference, has an association with microalbuminuria. METHODS: We analyzed anthropometric and biochemical data from a nation-wide, population-based, cross-sectional study. A total of 1605 participants included were healthy native Korean 40years or older and divided into quintiles according to their log-FLI and sex...
August 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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