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Clinica Chimica Acta; International Journal of Clinical Chemistry

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https://www.readbyqxmd.com/read/29462592/platelet-lymphocyte-ratio-acts-as-an-independent-predictor-of-prognosis-in-patients-with-renal-cell-carcinoma
#1
Zhun Wang, Shuanghe Peng, Aixiang Wang, Hui Xie, Linpei Guo, Ning Jiang, Yuanjie Niu
BACKGROUND: The prognostic value of plated-lymphocyte ratio (PLR) in multiple malignancies had been investigated in previous studies; however, its prognostic value in renal cell carcinoma (RCC) remains controversial. This study was performed to assess the prognostic value of preoperative PLR in RCC patients. METHODS: Literature was searched from PubMed, Embase, Web of Science and Cochrane database, which evaluated the relationships between preoperative PLR and prognosis in RCC patients...
February 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29458051/elevated-systemic-zonula-occludens-1-is-positively-correlated-with-inflammation-in-cirrhosis
#2
Ashwini Karthikeyan, Pazhanivel Mohan, Palanivel Chinnakali, Balasubramaniyan Vairappan
BACKGROUND/AIM: It has been well established that disruption of the intestinal barrier function and increased intestinal permeability contribute to endotoxemia and associated liver injury in patients with cirrhosis. However, the relationship between systemic inflammation and tight junction protein in cirrhosis remain unidentified. The aim of this study was to assess and compare the blood concentrations of ZO-1 with systemic hsCRP in patients with cirrhosis and healthy individuals. METHODS: 30 cirrhotic patients and 30 healthy individuals were enrolled in the study...
February 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29458050/investigation-of-metabolic-stability-of-the-novel-alk-inhibitor-brigatinib-by-liquid-chromatography-tandem-mass-spectrometry
#3
Hany W Darwish, Adnan A Kadi, Mohamed W Attwa, Halah S Almutairi
Brigatinib (BGB) belongs to a class of drugs called ALK inhibitor. On April 28, 2017, BGB has been approved by U.S. FDA for use in metastatic ALK-positive NSCLC. A fast, specific, sensitive and validated LC-MS/MS method was developed for the quantification of BGB in human plasma matrix. This method was applied successfully to study metabolic stability of BGB. Reversed phase (C18 column) and isocratic binary mobile phase (55% 0.1% formic acid: 45% ACN) were used for chromatographic separation of BGB and ponatinib (IS)...
February 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29458049/a-comprehensive-brca1-2-ngs-pipeline-for-an-immediate-copy-number-variation-cnv-detection-in-breast-and-ovarian-cancer-molecular-diagnosis
#4
Paola Concolino, Roberta Rizza, Flavio Mignone, Alessandra Costella, Donatella Guarino, Ilaria Carboni, Ettore Capoluongo, Concetta Santonocito, Andrea Urbani, Angelo Minucci
No abstract text is available yet for this article.
February 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453971/prediction-value-of-serum-hbv-large-surface-protein-in-different-phases-of-hbv-infection-and-virological-response-of-chronic-hepatitis-b-patients
#5
Can Liu, Wennan Wu, Hongyan Shang, Sheng Lin, Zhen Xun, Er Huang, Jinpiao Lin, Bin Yang, Qishui Ou
BACKGROUND: Serum HBV large surface protein (HBV-LP) is an envelope protein that has a close relationship with HBV DNA level. This study is to explore the prediction value of HBV-LP in different phase of HBV infection and during antiviral therapy in chronic hepatitis B (CHB) patients. METHODS: A retrospective study was conducted in 2033 individuals, which included 1677 HBV infected patients in different phases and 356 healthy controls. HBV-LP, HBV serum markers and HBV DNA were detected by ELISA, CMIA and qRT-PCR, respectively...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453970/proton-nmr-based-serum-metabolic-profile-correlates-with-the-neurological-recovery-in-treated-acute-spinal-cord-injury-asci-subjects-a-pilot-study
#6
Alka Singh, Rajeshwar Nath Srivastava, Ashok Agrahari, Suruchi Singh, Saloni Raj, Tanushri Chatterji, Abbas Ali Mahdi, Ravindra Kumar Garg, Raja Roy
BACKGROUND: Acute Spinal Cord Injury (ASCI) is still having substantial morbidity and mortality despite of advanced therapeutics. Major obstacles are paucity of monitoring tools or biomarkers for severity determination, recovery and prognostication. A prospective case control pilot study with serum 1 H NMR spectroscopic metabolic profiling was carried out to evaluate metabolites perturbations and its relationship with recovery and to see role of stem cells in facilitating neurological recovery...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453969/s100-proteins-in-oral-squamous-cell-carcinoma
#7
REVIEW
Muhammad Arsalan Raffat, Naila Irum Hadi, Mervyn Hosein, Sana Mirza, Sana Ikram, Zohaib Akram
BACKGROUND: Controversy exists in the literature regarding the differential expression of S100 protein members and their functional correlations in oral squamous cell carcinoma (OSCC). The aim of the present study was to systematically review the expression of S100 protein family members among OSCC and healthy controls and to evaluate whether S100 protein members serve as diagnostic marker in OSCC. METHODS: Indexed databases were searched up to and including October 2017...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453968/lipoprotein-lipase-biosynthesis-regulatory-factors-and-its-role-in-atherosclerosis-and-other-diseases
#8
REVIEW
Ping-Ping He, Ting Jiang, Xin-Ping OuYang, Ya-Qin Liang, Jie-Qiong Zou, Yan Wang, Qian-Qian Shen, Li Liao, Xi-Long Zheng
Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL). A variety of parenchymal cells can synthesize and secrete LPL. Recent studies have demonstrated that complicated processes are involved in LPL biosynthesis, secretion and transport. The enzyme activity of LPL is regulated by many factors, such as apolipoproteins, angiopoietins, hormones and miRNAs...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29452082/pre-treatment-red-blood-cell-distribution-width-provides-prognostic-information-in-multiple-myeloma
#9
Di Zhou, Peipei Xu, Miaoxin Peng, Xiaoyan Shao, Miao Wang, Jian Ouyang, Bing Chen
BACKGROUND: The red blood cell distribution width (RDW), a credible marker for abnormal erythropoiesis, has recently been studied as a prognostic factor in oncology, but its role in multiple myeloma (MM) hasn't been thoroughly investigated. METHODS: We performed a retrospective study in 162 patients with multiple myeloma. Categorical parameters were analyzed using Pearson chi-squared test. The Mann-Whitney and Wilcoxon tests were used for group comparisons. Comparisons of repeated samples data were analyzed with the general linear model repeated-measures procedure...
February 13, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29447902/the-erythrocyte-osmotic-resistance-test-as-screening-tool-for-cholesterol-related-lysosomal-storage-diseases
#10
Laura López de Frutos, Jorge J Cebolla, Pilar Irún, Ralf Köhler, Pilar Giraldo
BACKGROUND: Erythrocyte volume regulation and membrane elasticity are essential for adaptation to osmotic and mechanical stress, and life span. Here, we evaluated whether defective cholesterol trafficking caused by the rare lysosomal storages diseases (LSDs), Niemann-Pick type C (NPC) and Lysosomal acid lipase (LAL) deficiency (LALD) impairs these properties. Moreover, we tested whether measurements of cholesterol membrane content and osmotic resistance serve as a screening test for these LSDs...
February 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29438681/the-diagnostic-value-of-five-serum-tumor-markers-for-patients-with-cholangiocarcinoma
#11
Yuanfu Qiu, Jian He, Xinliang Chen, Pinbo Huang, Kaishun Hu, Haiyan Yan
OBJECTIVE: To assess the clinical significance and diagnostic value of the single and combined detection of five tumor markers in patients with cholangiocarcinoma. METHODS: In total, 296 patients with biliary tract disease who were diagnosed and received treatment at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University during April 2011 to Dec 2017 were chosen for this study. Patients were divided into a cholangiocarcinoma group and a benign biliary tract disease group...
February 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29432710/serum-cystatin-c-is-independently-associated-with-aortic-arterial-stiffness-in-patients-with-type-2-diabetes
#12
I-Min Su, Du-An Wu, Chung-Jen Lee, Jia-Sian Hou, Bang-Gee Hsu, Ji-Hung Wang
BACKGROUND: Higher cystatin C levels are associated with an increased cardiovascular risk. We evaluated the association between serum cystatin C and aortic arterial stiffness in patients with type 2 diabetes mellitus (DM). METHODS: Fasting blood samples were collected from 170 patients with type 2 DM. Carotid-femoral pulse wave velocity (cfPWV) values > 10 m/s were used to define the high aortic arterial stiffness group. RESULTS: Sixty-seven patients with DM (39...
February 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29428198/sex-specific-associations-of-serum-uric-acid-with-metabolic-syndrome-in-chinese-rural-population-the-ruraldiab-study
#13
Honglei Zhang, Yuqian Li, Zhenxing Mao, Xiaotian Liu, Xia Zhang, Kaili Yang, Ruihua Liu, Xinling Qian, Haiqing Zhang, Jingjing Jiang, Gongyuan Zhang, Chongjian Wang
BACKGROUND: We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) in Chinese rural adults. METHODS: A total of 16,577 subjects (6354 men and 10,223 women) were from the RuralDiab study. SUA concentration was measured by the enzymatic colorimetric method. A meta-analysis including 12 eligible studies focused on SUA and MetS was preformed to confirm the findings of the cross-sectional study. RESULTS: After adjustment for age, educational level, and other covariates, the odds ratio (ORs) for MetS increased smoothly with the increasing SUA concentration in both sexes (P for no-linear trend > 0...
February 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29428199/elevated-soluble-st2-concentration-may-involve-in-the-progression-of-atrial-fibrillation
#14
Xu Ma, Hui Yuan, Hai-Xia Luan, Ya-Li Shi, Xiao-Li Zeng, Yan Wang
BACKGROUND: The aim of this study is to investigate the value of soluble suppression of tumorigenicity 2 (sST2) in Atrial fibrillation (AF) patients' risk prediction. METHODS: Healthy people (n = 60) and AF patients (n = 194) were consecutively enrolled into this project. RESULTS: In the health group, the mean age was 54 y (55% males). Serum median concentration of sST2 in healthy individuals was 17.04 ng/ml. In the AF patients group, the mean age was 61 years, and 64% were males...
February 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29427582/increased-plasma-nesfatin-1-levels-may-be-associated-with-corticosterone-il-6-and-crp-levels-in-patients-with-major-depressive-disorder
#15
Qing-Rong Xia, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Ya-Yun Xu
OBJECTIVES: The aim of the present study was to evaluate the plasma nesfatin-1, corticosterone, and inflammatory cytokine (IL-6, CRP, and TNF-α) concentrations cross-sectionally in patients with major depressive disorder. METHODS: Subjects in the patient group were randomly selected from the Anhui Mental Health Center, and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index...
February 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29425670/robustness-of-the-beckman-coulter-access-tsh-3rd-is-assay
#16
LETTER
Dina N Green, Patrick C Mathias
No abstract text is available yet for this article.
February 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29421151/fractional-excretion-as-a-new-marker-of-tubular-damage-in-children-with-chronic-kidney-disease
#17
Kinga Musiał, Danuta Zwolińska
OBJECTIVES: Vitamin D-binding protein (VDBP), retinol-binding protein (RBP)4, and heat shock proteins (hsp) are markers of tubular function and apoptosis, accompanying chronic kidney disease (CKD) from its earliest stages. Fractional excretion of proteins with urine is a marker of tubular damage. The aim of study was to assess the usefulness of fractional excretion (FE) of VDBP, RBP4, HSF1 and Hsp27 as markers of tubular damage in the course of CKD. METHODS: The study group consisted of 70 children with CKD stages 1-5, treated conservatively, and 12 age-matched controls with normal kidney function...
February 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29408173/pten-in-kidney-cancer-a-review-and-meta-analysis
#18
REVIEW
Wan-Cai Que, Hong-Qiang Qiu, Yu Cheng, Mao-Bai Liu, Chao-Yang Wu
BACKGROUND: Kidney cancer is one of the most common cancers in the USA causing 14,400 deaths per year. The phosphatase and tensin homolog (PTEN) has been extensively documented as a tumor suppresser gene in cancer. However, there is unclear evidence for its clinicopathological and prognostic role in kidney cancer. METHODS: A systematic review of literature assessing PTEN expression and clinical outcome in patients with kidney cancer. Web of Science, PubMed, Embase, and Chinese databases were searched for collecting for the eligible studies providing sufficient information...
February 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29408170/acute-phase-reactant-pentraxin-3-as-a-novel-marker-for-the-diagnosis-of-rheumatoid-arthritis
#19
A Sharma, R Khan, N Gupta, A Sharma, M S Zaheer, M Abbas, S A Khan
INTRODUCTION: Pentraxins are a group of highly conserved acute-phase reactant proteins and play crucial role as modulators of inflammatory processes. Pentraxin 3 (PTX3) is primarily produced and released by vascular cell wall, hence, we attempt to establish the role of PTX3 as a biomarker for Rheumatoid Arthritis (RA) compared to CRP. METHODS: Thirty patients having active RA as cases and 30 osteoarthritis (OA) patients as controls were recruited. Paired serum and synovial fluid samples were analysed for concentrations of both PTX3 and CRP by using high sensitivity ELISA kit and ROC curve was plotted...
February 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29407693/the-value-of-red-blood-cell-distribution-width-in-diagnosis-of-patients-with-colorectal-cancer
#20
Dianyu Yang, Wenqiang Quan, Junlu Wu, Xiaoyi Ji, Yan Dai, Weidong Xiao, Helen Chew, Zujun Sun, Dong Li
BACKGROUND: Red blood cell distribution width (RDW) is a parameter of standard full blood count tests that reflects the size variability of erythrocytes In recent studies, RDW levels have been associated with ischemic heart disease, acute and chronic heart failure, hypertension, and inflammatory bowel disease. However, it is unclear whether RDW is associated with colorectal cancer. METHODS: Eighty-five patients were diagnosed with colorectal cancer. Fifty-four other patients each diagnosed with colon polyps during the same period served as the control group...
February 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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