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Clinica Chimica Acta; International Journal of Clinical Chemistry

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https://www.readbyqxmd.com/read/28645551/association-between-blood-vitamin-d-and-myocardial-infarction-a-meta-analysis-including-observational-studies
#1
REVIEW
Jizhen Huang, Zhiwei Wang, Zhipeng Hu, Wanli Jiang, Bowen Li
BACKGROUND: The association between blood vitamin D levels and the risk of myocardial infarction (MI) is controversial. This meta-analysis aimed to describe the relationship between MI risk and blood vitamin D levels. METHODS: Online databases were searched in PubMed, EMBASE and Web of science till February 2017 for observational studies in relation to reporting the vitamin D levels in MI cases and non-MI controls. The weighted mean difference (WMD) or odds ratio (OR), with 95% confidence interval (CI), were calculated to evaluate the relationship between MI risk and blood vitamin D levels...
June 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28641961/wnt5a-and-its-signaling-pathway-in-angiogenesis
#2
REVIEW
Ya-Ning Shi, Neng Zhu, Chan Liu, Hong-Tao Wu, Yu Gui, Duan-Fang Liao, Li Qin
Wnt5a, a secreted glycoprotein, belongs to the noncanonical Wnt family involved in a wide range of organism development and tissue homeostasis. Wnt5a and its signaling pathway can regulate fundamental cellular processes, including specification of cell fate, proliferation, and survival. Accumulating evidence indicates that Wnt5a exhibits dual effects on angiogenesis. The formation of new blood vessels derives from pre-existing vessels via canonical and non-canonical Wnt pathways, depending on cell types, receptors, downstream effectors, and microenvironment...
June 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28633928/clinical-immunophenotype-of-nasopharyngeal-neuroendocrine-carcinoma-with-metastatic-liver-cancer
#3
Chao Guo, Qijin Pan, Min Su, Rong Li
BACKGROUND: Nasopharyngeal neuroendocrine carcinoma (NNC) refers to a rare and lethal cancer, characterized with high risk of metastases. Here, we report a case of nasopharyngeal neuroendocrine carcinoma with subsequent liver metastases to discuss its clinical immunophenotype and challenges. METHODS: In clinical biochemical assays, hematological determination, immunohistochemical examination, imaging medicine investigations, and therapeutical analysis were subjected to the hospitalized patient, respectively...
June 17, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28625681/variation-of-calcium-copper-and-iron-levels-in-serum-bile-and-stone-samples-of-patients-having-different-types-of-gallstone-a-comparative-study
#4
Mustafa Khan, Tasneem Gul Kazi, Hassan Imran Afridi, Sirajuddin, Muhammad Bilal, Asma Akhtar, Sabir Khan, Salma Kadar
BACKGROUND: Epidemiological data among the human population has shown a significantly increased incidence of gallstone (GS) disease worldwide. It was studied that some essential (calcium) and transition elements (iron and copper) in bile play an important role in the development of GS. METHOD: The estimation of calcium, copper and iron were carried out in the serum, gall bladder bile and different types of GS (cholesterol, mixed and pigmented) of 172 patients, age ranged 20-55years...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28624501/new-biomarkers-for-diagnosis-and-management-of-polycystic-ovary-syndrome
#5
REVIEW
Sidika E Karakas
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting young women. Even though the definition of PCOS has changed over the years, all diagnostic criteria include two or more of the following: oligomenorrhea/oligoovulation/anovulation, androgen excess and polycystic ovaries (PCO). Traditional method of assessing the ovarian morphology has been transvaginal pelvic ultrasound. Recent studies support that serum anti-Mullerian hormone (AMH) levels correlate with the number of ovarian follicles and cysts...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28624500/phoenixin-14-concentrations-are-increased-in-association-with-luteinizing-hormone-and-nesfatin-1-concentrations-in-women-with-polycystic-ovary-syndrome
#6
Kamran Ullah, Tanzil Ur Rahman, Dan-Dan Wu, Xian-Hua Lin, Ye Liu, Xiao-Yan Guo, Peter C K Leung, Run-Ju Zhang, He-Feng Huang, Jian-Zhong Sheng
BACKGROUND: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28624499/evaluation-of-whole-exome-sequencing-by-targeted-gene-sequencing-and-sanger-sequencing
#7
Ya-Sian Chang, Hsien-Da Huang, Kun-Tu Yeh, Jan-Gowth Chang
BACKGROUND: Targeted gene sequencing (TGS) and whole exome sequencing (WES) are being used in clinical testing in laboratories. We compared the performances of TGS and WES using the same DNA samples. METHODS: DNA was extracted from 10 endometrial tumor tissue specimens. Sequencing were performed with an Illumina HiSeq 2000. We randomly selected variants to confirm through Sanger sequencing or mutant-enriched PCR with Sanger sequencing. RESULTS: We found that the variants identified in both TGS and WES were true positives (47/47), regardless of the sequencing depth...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28624498/impact-of-glycemic-variability-on-the-occurrence-of-periprocedural-myocardial-infarction-and-major-adverse-cardiovascular-events-mace-after-coronary-intervention-in-patients-with-stable-angina-pectoris-at-6months-follow-up
#8
Jinggang Xia, Ji Xu, Shaodong Hu, Hengjian Hao, Chunlin Yin, Dong Xu
BACKGROUND: We explored the impact of glycemic variability on the occurrence of periprocedural myocardial infarction and major adverse cardiovascular events (MACE) after coronary intervention in patients with stable angina pectoris (SAP) at 6months follow-up. METHODS: From May 2015 to April 2016, a total of 746 patients with SAP were divided to high glycemic variability group (H group) (n=261) and low glycemic variability group (L group) (n=485). The primary end point was incidence of periprocedural myocardial infarction and MACE at 6months follow-up...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28622967/new-markers-of-urinary-tract-infection
#9
REVIEW
Anna Masajtis-Zagajewska, Michal Nowicki
Urinary tract infection (UTI) is the most common bacterial infection independent of age. It is also one of the most common causes of hospitalizations for infections among elderly people and the most common indication for antibiotic prescriptions in primary care. Both diagnostics and management of lower and upper urinary tract infections provide challenges in clinical practice due to their high prevalence and recurrence, and worldwide increase of antibiotic resistance. The clinical symptoms of UTI are often uncharacteristic or asymptomatic...
June 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28622966/immunohistochemical-expression-analysis-of-leucine-rich-ppr-motif-containing-protein-lrpprc-a-candidate-colorectal-cancer-biomarker-identified-by-shotgun-proteomics-using-itraq
#10
Tomohisa Nishio, Nobuya Kurabe, Naoko Goto-Inoue, Toshio Nakamura, Haruhiko Sugimura, Mitsutoshi Setou, Masato Maekawa
BACKGROUND: Colorectal cancer (CRC) is the fourth most frequent cause of cancer deaths in the world. Novel biomarkers for the diagnosis, prognosis, and treatment of CRC are required to improve the clinical strategy. METHODS: We applied shotgun proteomics using isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel biomarkers of CRC, and then we detected leucine-rich PPR-motif-containing protein (LRPPRC) expression in 83 normal colorectal tissues and 133 CRC tissues by immunohistochemistry...
June 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28619360/further-delineation-of-cog8-cdg-a-case-with-novel-compound-heterozygous-mutations-diagnosed-by-targeted-exome-sequencing
#11
Aram Yang, Sung Yoon Cho, Ja-Hyun Jang, Jinsup Kim, Sook Za Kim, Beom Hee Lee, Han-Wook Yoo, Dong-Kyu Jin
Congenital disorders of glycosylation (CDG) are a rapidly expanding group of inherited metabolic disorders with highly variable clinical presentations caused by deficient glycosylation of proteins and/or lipids. CDG-IIh is a very rare subgroup of CDG caused by mutations in the conserved oligomeric Golgi (COG) complex gene, COG8, and so far, only two cases have been reported in the medical literature. Here, we describe an 8-year-old Korean boy with psychomotor retardation, hypotonia, failure to thrive, elevated serum liver enzymes, microcephaly, and talipes equinovarus...
June 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28606604/the-ability-of-the-wide-range-crp-assay-to-classify-individuals-with-low-grade-inflammation-into-cardiovascular-risk-groups
#12
Tomer Ziv-Baran, Shani Shenhar-Tsarfaty, Inbal Etz-Hadar, Ilana Goldiner, Ahuva Gottreich, Yifat Alcalay, David Zeltser, Itzhak Shapira, Yoel Angel, Limor Friedensohn, Michal Ehrenwald, Shlomo Berliner, Ori Rogowski
BACKGROUND: High sensitivity C-reactive protein (hsCRP) has become a routine assessment tool to discriminate between patients at low, intermediate or high risk for cardiovascular events using the threshold values of 1 and 3mg/L, respectively. Over the past years, several studies have proposed the wide range C-reactive protein (wrCRP) as an alternative to the hsCRP in various clinical scenarios. However, the potential use of wrCRP in assessing the cardiovascular risk has not yet been evaluated...
June 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28602964/droplet-digital-pcr-improved-the-egfr-mutation-diagnosis-with-pleural-fluid-samples-in-non-small-cell-lung-cancer-patients
#13
Xiaoyan Li, Yi Liu, Weiwei Shi, Huayan Xu, Haixu Hu, Zhengwei Dong, Guanshan Zhu, Yun Sun, Bing Liu, Hongjun Gao, Chuanhao Tang, Xiaoqing Liu
BACKGROUND: Droplet digital polymerase chain reaction (ddPCR) is a promising method for analyzing minor amounts of nucleic acid. However, its application has not been reported in pleural fluid, which is an ideal sample source for epidermal growth factor receptor (EGFR) mutation analysis in non-small-cell lung cancer (NSCLC) patients. METHODS: The extracted DNA from supernatants of pleural fluid was selected from our sample bank and re-analyzed by our previously established ddPCR assay...
June 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28601671/ebv-infection-and-msi-status-significantly-influence-the-clinical-outcomes-of-gastric-cancer-patients
#14
Hua Shen, Meizuo Zhong, Weili Wang, Ping Liao, Xianli Yin, Daniel Rotroff, Todd C Knepper, Howard L Mcleod, Chengfang Zhou, Shangchen Xie, Wei Li, Biaobo Xu, Yijing He
BACKGROUND: Epstein-Barr virus (EBV) and microsatellite instability (MSI) are associated with the carcinogenesis of many kinds of tumors, including gastric cancer (GC). However, the impact of EBV and MSI status on the prognosis of stage II and III GC is still unclear. The aim of this study was to find out the prognostic value of EBV and MSI status in a population of GC patients from Southern China. METHODS: Patients were genotyped for EBV infection based on the detection of EBV DNA from the formalin-fixed paraffin-embedded (FFPE) specimens...
June 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28601670/oxidized-ldl-but-not-total-ldl-is-associated-with-hba1c-in-individuals-without-diabetes
#15
Débora Spessatto, Liz Marina Bueno Dos Passos Brum, Joíza Lins Camargo
OBJECTIVE: This study investigates the association between HbA1c, LDL and oxi-LDL in individuals without diabetes (DM). METHODS: One hundred and ninety-six individuals, without DM, were enrolled and divided into three groups according to HbA1c and fasting plasma glucose values. HbA1c, oxi-LDL, LDL, and other biochemical measurements of lipid profile were also carried out. RESULTS: oxi-LDL levels showed significant differences among all groups and group 3 presented higher values [34U/L (27-46); 44U/L (37-70); and 86U/L (49-136); p<0...
June 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28601669/the-diagnostic-value-of-rescaled-renal-biomarkers-serum-creatinine-and-serum-cystatin-c-and-their-relation-with-measured-glomerular-filtration-rate
#16
Hans Pottel, Laurence Dubourg, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J Lamb, Andrew D Rule, Stephen T Turner, Richard J Glassock, Vandréa De Souza, Luciano Selistre, Karolien Goffin, Steven Pauwels, Christophe Mariat, Martin Flamant, Sebastjan Bevc, Pierre Delanaye, Natalie Ebert
BACKGROUND: Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between 'rescaled' levels of these renal biomarkers (with reference interval of [0.67-1.33]) and measured GFR (mGFR). METHODS: We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC...
June 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28587955/-daisy-like-crystals-a-rare-and-unknown-type-of-urinary-crystal
#17
G B Fogazzi, R Anderlini, S Canovi, C Covarelli, J Gras, J Kučera, A Proietti, D Rogic, R Teboul, C Ferraris Fusarini, F de Liso, G Garigali, M Daudon
BACKGROUND: Crystals are well known structures of urinary sediment, most of which are identified by the combined knowledge of crystal morphology, birefringence features at polarized light, and urine pH. In this paper, we report on a cohort of subjects whose urine contained a very rare type of crystal, which we first described in 2004 and which, based on its peculiar morphology, we define as "daisy-like crystal" (DLcr). METHODS: Reports on DLcr were spontaneously sent to our laboratory over a 10...
June 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28587954/increased-admission-serum-cold-inducible-rna-binding-protein-concentration-is-associated-with-prognosis-of-severe-acute-pancreatitis
#18
Jian-De Gong, Xu-Fei Qi, Yi Zhang, Hong-Liang Li
BACKGROUND: Cold-inducible RNA-binding protein (CIRP) is a pro-inflammatory cytokine. This study assessed its relation to disease severity and major adverse events (namely local complications, organ failure and in-hospital mortality) of severe acute pancreatitis (SAP) and its discriminatory ability for SAP. METHODS: This prospective and observational study recruited a total of 102 SAP patients, 48 patients with mild acute pancreatitis and 102 healthy individuals...
June 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28579142/stability-of-lyophilized-pooled-sera-as-quality-control-materials-for-tumor-marker-assays-in-external-quality-assessment
#19
Sunyoung Ahn, Jungyong Park, Young Ran Kim, Jeong-Ho Kim, Hyon-Suk Kim
BACKGROUND: External quality assessment (EQA) requires stable quality control (QC) materials. We evaluated the stability of QC materials made of lyophilized and liquid pooled sera for the tumor markers α-fetoprotein, carcinoembryonic antigen, carbohydrate antigen 125, and carbohydrate antigen 19-9. METHODS: Specimens of the 4 tumor markers were collected from the sera of patients and stored at -20°C. After sera collection and pooling, liquid or lyophilized samples were stored at -20°C, 5°C, or room temperature...
June 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28579141/diagnostic-potential-of-inflammatory-biomarkers-in-early-childhood-caries-a-case-control-study
#20
Vrinda Sharma, Nidhi Gupta, Nikhil Srivastava, Vivek Rana, Preetika Chandna, Savita Yadav, Alpana Sharma
BACKGROUND: Early Childhood Caries (ECC) is most common chronic infectious disease of childhood. Diagnosis of dental caries has been limited to clinical, visual and radiographic methods but its inflammatory component remained unexplored. Hence, this study aims to evaluate salivary levels of inflammatory cytokines in children with ECC to assess their potential as non-invasive biomarkers. METHODS: 50 subjects were recruited (25 ECC patients and 25 healthy children)...
June 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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