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European Journal of Immunology

Oliver Schweier, Ulrike Aichele, Anna-Friederike Marx, Tobias Straub, J Sjef Verbeek, Daniel D Pinschewer, Hanspeter Pircher
Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8+ T cells independently of CD4+ T cell help. Residual viral antigen may, however, persist for a prolonged time. Here, we demonstrate that mice that had been transiently depleted of CD4+ T cells during acute LCMV Arm infection generated high levels of virus-specific IgG antibodies (Ab) after viral clearance. Robust induction of LCMV-specific IgG after transient CD4+ T cell depletion was dependent on Fcγ receptors but not on the complement receptors CD21/CD35...
January 12, 2019: European Journal of Immunology
Shida Yousefi, Darko Stojkov, Nina Germic, Dagmar Simon, Xiaoliang Wang, Charaf Benarafa, Hans-Uwe Simon
Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins. This process does not depend on cell death, but requires glycolytic ATP production for rearrangements in the microtubule network and F-actin. Such cytoskeletal rearrangements are essential for both mitochondrial DNA release and degranulation...
January 10, 2019: European Journal of Immunology
Angela M Thornton, Jinghua Lu, Patricia E Korty, Yong Chan Kim, Craig Martens, Peter D Sun, Ethan M Shevach
The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios- Treg were induced from Foxp3- T conventional (Tconv) cells in the periphery (pTreg). To compare the two Treg subpopulations, we generated Helios-GFP reporter mice and crossed them to Foxp3-RFP reporter mice. The Helios+ Treg population expressed a more activated phenotype, had a slightly higher suppressive capacity in vitro and expressed a more highly demethylated TSDR but were equivalent in their ability to suppress inflammatory bowel disease in vivo...
January 8, 2019: European Journal of Immunology
Nicole Müller, Julius C Fischer, Monica Yabal, Tobias Haas, Hendrik Poeck, Philipp J Jost
No abstract text is available yet for this article.
December 25, 2018: European Journal of Immunology
Marsilius Mues, Gurumoorthy Krishnamoorthy
No abstract text is available yet for this article.
December 22, 2018: European Journal of Immunology
Sebastian Fuchs, Nadia Sawas, Nicolas Staedler, David A Schubert, Annalisa D'Andrea, Robert Zeiser, Luca Piali, Petr Hruz, Andreas P Frei
Immune checkpoints are regulators of immune cells and play key roles in the modulation of immune responses. The role of checkpoints in autoimmune disease is poorly understood but likely to be central since checkpoint inhibition during cancer treatment can cause autoimmunity. We generated a high-dimensional single-cell proteomics data set from PBMCs of healthy individuals and patients with ulcerative colitis (UC) by mass cytometry, enabling systems-wide analyses of immune cell frequencies and cell type-specific expression patterns of 12 immune checkpoints...
December 22, 2018: European Journal of Immunology
Xiaojuan Han, Hongtao Liu, Huarong Huang, Xinyuan Liu, Baoqian Jia, George Fu Gao, Fuping Zhang
Antigen-specific Th1 cells could traffic to the infection sites during infection to execute effector functions, such as help CD8+ T cells to localize in these sites by secretion of anti-viral cytokines-IFN-γ or direct cytotoxicity of antigen-bearing cells. However, the molecular components that modulate Th1 cell differentiation and function in response to viral infection remain incompletely understood. Here, we reported that both inhibitor of DNA binding 3(Id3) protein and inhibitor of DNA binding 2(Id2) protein promoted Th1 cell differentiation...
December 22, 2018: European Journal of Immunology
Saima Naz, Srikanth Battu, Rafiq Ahmad Khan, Sumbul Afroz, Jeevan Giddaluru, Sandeep Kumar Vishwakarma, Vishnupriya Satti, Md Aejaz Habeeb, Aleem Ahmed Khan, Nooruddin Khan
Immune cells sense and programme its cellular machinery appropriately to the environmental changes through the activation of cytoprotective adaptive pathway so-called the "integrated stress response (ISR)". However, the mechanisms implicated in ISR-induced protective responses are poorly understood. Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1β production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel post- transcriptional and translation regulatory (PTR) mechanism...
December 22, 2018: European Journal of Immunology
Diana Cortes-Selva, Andrew Ready, Lisa Gibbs, Bartek Rajwa, Keke C Fairfax
IL-4 is critical for differentiation of Th2 cells and antibody isotype switching, but our work demonstrated that it is produced in the peripheral lymph node (LN) under both Type 2, and Type 1 conditions, raising the possibility of other functions. We found that IL-4 is vital for proper positioning of hematopoietic and stromal cells in steady state, and the lack of IL-4 or IL-4Rα correlates with disarrangement of both follicular dendritic cells and CD31+ endothelial cells. We observed a marked disorganization of B cells in these mice, suggesting that the lymphocyte-stromal cell axis is maintained by the IL-4 signaling pathway...
December 21, 2018: European Journal of Immunology
Dan Wu, Jonathan M Han, Xin Yu, Avery J Lam, Romy E Hoeppli, Anne M Pesenacker, Qing Huang, Virginia Chen, Cate Speake, Ekua Yorke, Nam Nguyen, Sharadh Sampath, David Harris, Megan K Levings
Obesity-associated visceral adipose tissue (AT) inflammation promotes insulin resistance and type 2 diabetes (T2D). In mice, lean visceral AT is populated with anti-inflammatory cells, notably regulatory T cells (Tregs) expressing the IL-33 receptor ST2. Conversely, obese AT contains fewer Tregs and more pro-inflammatory cells. In humans, however, there is limited evidence for a similar pattern of obesity-associated immunomodulation. We used flow cytometry and mRNA quantification to characterize human omental AT in 29 obese, 18 of whom had T2D...
December 19, 2018: European Journal of Immunology
Anja Dolch, Stefanie Kunz, Britta Dorn, Francesca Alessandrini, Werner Muller, Robert S Jack, Stefan F Martin, Axel Roers, Thilo Jakob
Allergen specific tolerance induction efficiently ameliorates subsequent allergen induced inflammatory responses. The underlying regulatory mechanisms have been attributed mainly to interleukin (IL)-10 produced by diverse hematopoietic cells, while targets of IL-10 in allergen specific tolerance induction have not yet been well defined. Here, we investigate potential cellular targets of IL-10 in allergen specific tolerance induction using mice with a cell type specific inactivation of the IL-10 receptor gene...
December 19, 2018: European Journal of Immunology
Oskar Thofte, Ravinder Kaur, Yu Ching Su, Marta Brant, Anna Rudin, Derek Hood, Kristian Riesbeck
Non-typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and occasionally suffer from exacerbations by the bacterium leading to increased morbidity. Elongation-factor thermo unstable (EF-Tu), a protein critical for bacterial protein synthesis, has been found to moonlight on the surface of several bacteria...
December 19, 2018: European Journal of Immunology
Michio Shimamura, Shin-Ichi Kamijo, Petr Illarionov
No abstract text is available yet for this article.
December 13, 2018: European Journal of Immunology
Emily Gage, Neal Van Hoeven, Natasha Dubois Cauwelaert, Sasha E Larsen, Jesse Erasmus, Mark T Orr, Rhea N Coler
Influenza A annually infects 5-10% of the world's human population resulting in one million deaths. Influenza causes annual epidemics and re-infects previously exposed individuals because of antigenic drift in the glycoprotein hemagglutinin. Due to antigenic drift, the immune system is simultaneously exposed to novel and conserved parts of the influenza virus via vaccination and/or infection throughout life. Preexisting immunity has long been known to augment subsequent hemagglutination inhibitory antibody (hAb) responses...
December 12, 2018: European Journal of Immunology
Catalina Burbano, Jose A Gomez-Puerta, Carlos Muñoz-Vahos, Adriana Vanegas-García, Mauricio Rojas, Gloria Vásquez, Diana Castaño
Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Blood and urine samples from SLE patients were collected. In monocyte subsets from whole blood samples several phenotypic markers were evaluated...
December 10, 2018: European Journal of Immunology
Julien J Karrich, Mónica Romera-Hernández, Natalie Papazian, Sharon Veenbergen, Ferry Cornelissen, Patricia Aparicio-Domingo, Frances H Stenhouse, C Diana Peddie, Remco M Hoogenboezem, Chelsea W J den Hollander, Terri Gaskell, Tanya Medley, Louis Boon, C Claire Blackburn, David R Withers, Janneke N Samsom, Tom Cupedo
Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. In contrast, the molecular mechanisms allowing DCs to efficiently migrate through the complex extracellular matrix of the intestinal lamina propria prior to antigen encounter are still incompletely understood...
December 7, 2018: European Journal of Immunology
Orit Berhani, Ariella Glasner, Shira Kahlon, Alexandra Duev-Cohen, Rachel Yamin, Elad Horwitz, Jonatan Enk, Ofra Moshel, Alexandar Varvak, Angel Porgador, Stipan Jonjic, Ofer Mandelboim
Natural Killer (NK) cells are innate lymphocytes that efficiently eliminate cancerous and infected cells. NKp46 is an important NK activating receptor shown to participate in recognition and activation of NK cells against pathogens, tumor cells, virally infected cells, and self-cells in autoimmune conditions, including type I and II diabetes. However, some of the NKp46 ligands are unknown and therefore investigating human NKp46 activity and its critical role in NK cell biology is problematic. We developed a unique anti-human NKp46 monocloncal antibody, denoted hNKp46...
December 7, 2018: European Journal of Immunology
Anne S Dejean, Emeline Joulia, Thierry Walzer
Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2019. 49: XXXX-XXXX] Mazzoni et al. and Gruarin et al. studied the role of Eomes in human CD4 T-cell differentiation. Mazzoni et al. showed that Eomes plays a key role in helper T cell (Th) plasticity by favoring the phenotype shift of Th17 cells towards non-classic Th1 cells; while Gruarin et al...
December 7, 2018: European Journal of Immunology
Elisabeth G Bjørnsen, Lavanya Thiruchelvam-Kyle, Sigurd E Hoelsbrekken, Camilla Henden, Per C Saether, Preben Boysen, Michael R Daws, Erik Dissen
NK cells kill cancer cells and infected cells upon activation by cell surface receptors. Human NKp30 is an activating receptor expressed by all mature NK cells. The B7 family member B7H6 has been identified as one ligand for NKp30. Several alternative ligands have also been reported, and the field remains unsettled. To this end, we have identified full-length functional B7H6 orthologs in rat and cattle, demonstrated by phylogenetic analysis and transfection experiments. In cell-cell contact-dependent assays, chimeric NKp30 reporter cells responded strongly to B7H6 in rat and cattle...
December 4, 2018: European Journal of Immunology
Ramesh Chandra Halder, Cynthia Tran, Priti Prasad, Jing Wang, Dhiraj Nallapothula, Tatsuya Ishikawa, Meiying Wang, Dirk M Zajonc, Ram Raj Singh
Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid-reactive invariant NKT-cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid-reactive T-cells (PLT). We report that the normal mouse immune repertoire contains αβ T-cells, which recognize self-glycerophospholipids such as phosphatidic acid (PA) in a CD1d-restricted manner and don't cross-react with iNKT-cell ligands. PA bound to CD1d in the absence of lipid transfer proteins. Upon in vivo priming, PA induced an expansion and activation of T-cells in Ag-specific manner...
December 3, 2018: European Journal of Immunology
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