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Cardiology

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https://www.readbyqxmd.com/read/28697492/incidence-and-causes-for-early-ticagrelor-discontinuation-a-real-world-dutch-registry-experience
#1
Thomas O Bergmeijer, Paul W A Janssen, Mathijs van Oevelen, Dymphie van Rooijen, Thea C Godschalk, Johannes C Kelder, Vera H M Deneer, Victor L Serebruany, Jurriën M Ten Berg
OBJECTIVES: The PLATO trial revealed superiority of ticagrelor over clopidogrel for the prevention of atherothrombotic events in patients with acute coronary syndrome. However, adverse events such as bleeding, dyspnea, and bradycardia were frequently reported, potentially leading to excess early ticagrelor discontinuation (ETD), later confirmed in the PEGASUS trial. We here evaluated the incidence and causes for ETD in a real-world patient cohort in a high-volume nonacademic percutaneous coronary intervention center in the Netherlands...
July 12, 2017: Cardiology
https://www.readbyqxmd.com/read/28683456/can-noncardiac-syncope-occur-during-exercise
#2
Georgios A Christou, Konstantinos A Christou, Evangelos A Christou, Dimitrios N Kiortsis
We describe the case of a 25-year-old athlete experiencing syncope during a 5-km running race. A thorough diagnostic workup reasonably excluded a cardiac disorder as the cause of syncope. The characterization of this episode of syncope as noncardiac appears to contradict the common belief that syncope during exercise has always a cardiac origin. Following a detailed history taking, it was revealed that the symptoms of the athlete started after a 180° turn of the route. This situation represents a setting relevant to a runner who stops suddenly after reaching the finish line and soon after experiences noncardiac syncope due to the abrupt cessation of muscle pump function of the lower limbs...
July 6, 2017: Cardiology
https://www.readbyqxmd.com/read/28654925/cardiovascular-oncologic-emergencies
#3
Sundeep Shenoy, Safal Shetty, Shilpa Lankala, Faiz Anwer, Andrew Yeager, Sasikanth Adigopula
Oncologic emergencies can present either as a progression of a known cancer or as the initial presentation of a previously undiagnosed cancer. In most of these situations, a very high degree of suspicion is required to allow prompt assessment, diagnosis, and treatment. In this article, we review the presentation and management of cardiovascular oncologic emergencies from primary and metastatic tumors of the heart and complications such as pericardial tamponade, superior vena cava syndrome, and hyperviscosity syndrome...
June 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28654919/a-clinical-score-for-predicting-atrial-fibrillation-in-patients-with-cryptogenic-stroke-or-transient-ischemic-attack
#4
Calvin Kwong, Albee Y Ling, Michael H Crawford, Susan X Zhao, Nigam H Shah
OBJECTIVES: Detection of atrial fibrillation (AF) in post-cryptogenic stroke (CS) or transient ischemic attack (TIA) patients carries important therapeutic implications. METHODS: To risk stratify CS/TIA patients for later development of AF, we conducted a retrospective cohort study using data from 1995 to 2015 in the Stanford Translational Research Integrated Database Environment (STRIDE). RESULTS: Of the 9,589 adult patients (age ≥40 years) with CS/TIA included, 482 (5%) patients developed AF post CS/TIA...
June 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28651249/administration-of-the-mitochondrial-permeability-transition-pore-inhibitor-tro40303-prior-to-primary-percutaneous-coronary-intervention-does-not-affect-the-levels-of-pro-inflammatory-cytokines-or-acute-phase-proteins
#5
Noreen Butt, Lena K Bache-Mathiesen, Jan Erik Nordrehaug, Vegard Tuseth, Peter Scott Munk, Vernon Bonarjee, Trygve Sundby Hall, Svend Eggert Jensen, Sigrun Halvorsen, Huseyin Firat, Dan Atar, Alf Inge Larsen
OBJECTIVES: In the MITOCARE study, reperfusion injury was not prevented after administration of the mitochondrial permeability transition pore (mPTP) opening inhibitor, TRO40303, in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The effects of TRO40303 on pro-inflammatory cytokines and acute-phase proteins were assessed. METHODS: STEMI patients (n = 163, mean age 62 years) with chest pain within 6 h before admission for pPCI were randomized to intravenous bolus of TRO40303 (n = 83) or placebo (n = 80) prior to reperfusion...
June 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28651248/evaluation-of-plasma-thrombomodulin-in-patients-with-coronary-slow-flow
#6
Yong Wang, Peng-Yu Jia, Bao-Jun Chen, Yan Chen, Hang Yu, Yao Yu, Hui-Min Yang, Da-Lin Jia, Chun-Yan Ma
BACKGROUND: It has been reported that coronary slow flow (CSF) is associated with acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, and even sudden cardiac death. Although studies concerning the etiopathogenesis of CSF are scarce, diffuse atherosclerosis and endothelial dysfunction are thought to play important roles. It has been suggested that a high plasma thrombomodulin (TM) level seems to play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction...
June 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28641292/the-incidence-clinical-significance-and-treatment-effects-of-depression-in-cardiac-resynchronization-therapy-recipients
#7
Tomasz Podolecki, Robert Pudlo, Michal Mazurek, Monika Koziel, Ewa Jedrzejczyk-Patej, Joanna Boidol, Katarzyna Przybylska, Adam Sokal, Oskar Kowalski, Jacek Kowalczyk, Radoslaw Lenarczyk, Zbigniew Kalarus
OBJECTIVES: Chronic heart failure (HF) is associated with significantly increased prevalence of depression. The aim of the study was to assess the incidence and clinical impact of depression as well as the effectiveness of depression treatment in HF patients. METHODS: A prospective interventional trial included 285 consecutive cardiac resynchronization therapy recipients. Patients underwent a psychiatric examination at the time of implantation and then it was routinely repeated at 3, 6, and 12 months after the procedure, and every 6 months thereafter...
June 23, 2017: Cardiology
https://www.readbyqxmd.com/read/28618423/long-term-clinical-outcomes-of-the-carpentier-edwards-perimount-pericardial-bioprosthesis-in-chinese-patients-with-single-or-multiple-valve-replacement-in-aortic-mitral-or-tricuspid-positions
#8
Huiming Guo, Cong Lu, Huanlei Huang, Bin Xie, Jian Liu, Shaoyi Zheng, Ruixin Fan, Jimei Chen, Jian Zhuang
OBJECTIVES: To report the safety and efficacy results of a 9- to 15-year follow-up investigation among patients who had received Carpentier-Edwards Perimount (CE-P) bovine pericardial bioprostheses (Edwards Lifesciences, Irvine, CA, USA) for valve replacement. METHODS: This retrospective study investigated freedom from structural valve deterioration (SVD) as well as survival and reoperation among different age and etiology groups in patients who were implanted with a CE-P bioprosthesis at Guangdong General Hospital between 2001 and 2007...
June 16, 2017: Cardiology
https://www.readbyqxmd.com/read/28618414/failed-downregulation-of-circulating-microrna-155-as-a-marker-of-adverse-left-ventricular-remodeling-a-new-useful-tool-for-cardiologists
#9
https://www.readbyqxmd.com/read/28618412/failed-downregulation-of-circulating-microrna-155-in-the-early-phase-after-st-elevation-myocardial-infarction-is-associated-with-adverse-left-ventricular-remodeling
#10
Sam C Latet, Paul L Van Herck, Marc J Claeys, Amaryllis H Van Craenenbroeck, Steven E Haine, Tom R Vandendriessche, Viviane O Van Hoof, Erik Fransen, Benedicte Y De Winter, Emeline M Van Craenenbroeck, Hein Heidbuchel, Christiaan J Vrints, Vicky Y Hoymans
BACKGROUND: MicroRNA are noncoding RNA that have a significant role in both inflammatory and cardiovascular diseases. AIMS: We aimed to assess whether the inflammation-related microRNA-155 is associated with the development of adverse left ventricular (LV) remodeling following ST elevation myocardial infarction (STEMI). METHODS: Peripheral blood samples were collected in the inflammatory (day 2), proliferative (day 5), and maturation phases (6 months) after STEMI (n = 20)...
June 16, 2017: Cardiology
https://www.readbyqxmd.com/read/28618408/inflammatory-pathways-in-acute-myocardial-infarction-a-matter-of-prime-importance
#11
Gonzalo Luis Alonso Salinas, Marina Pascual Izco, José Luis Zamorano
No abstract text is available yet for this article.
June 16, 2017: Cardiology
https://www.readbyqxmd.com/read/28618405/upregulation-of-circulating-mir-195-3p-in-heart-failure
#12
Xia He, Jun Ji, Tao Wang, Ming-Bang Wang, Xiao-Ling Chen
OBJECTIVES: Many circulating microRNAs (miRs) have been shown to have potential biomarker effects in cardiovascular disease. We studied the dysregulation of circulating miR-195-3p in patients with heart failure (HF) to elucidate its value as a potential biomarker for HF. METHODS: Eight ischemic HF (IHF) patients, 8 nonischemic HF patients (NIHF), and 8 healthy volunteers (matched by age and sex - normal controls [NCs]) were chosen for miR sequencing. The plasma RNA was extracted, and a small RNA library of HF was established and then sequenced using next-generation sequencing (NGS) technology...
June 16, 2017: Cardiology
https://www.readbyqxmd.com/read/28614834/left-ventricular-mechanical-reverse-remodelling-not-followed-by-electrical-reverse-remodelling-a-case-report
#13
Sandra Amorim, Raquel Garcia, Teresa Pinho, João Rodrigues, Filipe Macedo, José Silva-Cardoso, M Júlia Maciel
Patients with severely depressed left ventricular ejection fractions (LVEFs) receive implantable cardioverter-defibrillators (ICDs) for the primary prevention of sudden death. However, in some patients, LVEFs may improve or even normalize over time, and these patients would no longer be qualified for ICD implantation based on the original criteria for which they have initially received an ICD. We report a patient with idiopathic dilated cardiomyopathy whose LVEF recovered to normal values after pharmacological therapy...
June 15, 2017: Cardiology
https://www.readbyqxmd.com/read/28609767/improving-outcomes-in-high-risk-percutaneous-coronary-interventions-and-newer-generation-drug-eluting-stents-good-but-not-good-enough
#14
Usman Baber, Roxana Mehran
No abstract text is available yet for this article.
June 14, 2017: Cardiology
https://www.readbyqxmd.com/read/28609765/transcatheter-treatment-of-aortopulmonary-window-with-a-symmetrical-membranous-ventricular-septal-occluder
#15
Hai-Xia Xu, Dong-Dong Zheng, Min Pan, Xiao-Fei Li
Aortopulmonary window (APW), the presence of a communication between aorta and pulmonary artery, is a rare congenital heart disease, and surgical intervention is the standard for closure. Recently, several cases have been treated with transcatheter device occluders. Here, we report an APW patient treated successfully using a transcatheter closure with a symmetrical membranous ventricular septal occluder. We are the first to report on a case treated with this type of occluder for APW.
June 14, 2017: Cardiology
https://www.readbyqxmd.com/read/28605744/a-clinical-case-of-catecholaminergic-polymorphic-ventricular-tachycardia-the-clinical-suspicious-and-the-need-of-genetics
#16
Annamaria Del Franco, Francesca Gualandi, Michele Malagù, Alessandra Ferlini, Dang Xiao, Roberto Ferrari, Matteo Bertini
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a very rare genetic cardiac channelopathy, which has not been sufficiently studied yet. The first clinical manifestation has been described during the first decade of life, linked to strenuous exercise or acute emotion. The absence of structural heart disease and a family history of possible arrhythmogenic disorder generally guide the diagnosis towards a potential channelopathy. The opportunity to perform an extensive genetic analysis allows physicians to make the correct diagnosis and to optimize clinical management...
June 13, 2017: Cardiology
https://www.readbyqxmd.com/read/28605731/why-all-the-pushback-against-counterpulsation
#17
Phillip J Habib, Susan M Joseph
No abstract text is available yet for this article.
June 13, 2017: Cardiology
https://www.readbyqxmd.com/read/28601882/bioabsorbable-scaffolds-can-the-problems-of-dissolution-be-overcome
#18
Mary C Shields, Sheldon Goldberg
No abstract text is available yet for this article.
June 10, 2017: Cardiology
https://www.readbyqxmd.com/read/28578331/whole-genome-sequence-identified-a-rare-homozygous-pathogenic-mutation-of-the-dsg2-gene-in-a-familial-arrhythmogenic-cardiomyopathy-involving-both-ventricles
#19
Yubi Lin, Qianhuan Zhang, Zhi An Zhong, Zhe Xu, Siqi He, Fang Rao, Yang Liu, Jiaojiao Tang, Feng Wang, Hui Liu, Jiajun Xie, Hongmei Wu, Shuxia Wang, Xin Li, Zhixin Shan, Chunyu Deng, Zili Liao, Hai Deng, Hongtao Liao, Yumei Xue, Wanqun Chen, Xianzhang Zhan, Bin Zhang, Shulin Wu
BACKGROUND: This study was designed to identify the pathogenic mutation in a Chinese family with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) using whole genome sequencing (WGS). METHODS AND RESULTS: Probands II:1 and II:2 underwent routine examinations for diagnosis. Genomic DNA was extracted from the peripheral blood of family members and analyzed using WGS. A total of 60,285 single-nucleotide polymorphisms (SNP) and 13,918 insertions/deletions (InDel) occurring in the exonic regions of genes and predisposing to cardiomyopathies and arrhythmias were identified...
June 3, 2017: Cardiology
https://www.readbyqxmd.com/read/28571039/johnny-can-t-read-and-it-is-killing-him
#20
Robert Chait
No abstract text is available yet for this article.
June 2, 2017: Cardiology
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