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George Latsios, Kostas Toutouzas, Dimitris Tousoulis
No abstract text is available yet for this article.
August 10, 2018: Cardiology
Daan Aeyels, Luk Bruyneel, Peter R Sinnaeve, Marc J Claeys, Sofie Gevaert, Danny Schoors, Massimiliano Panella, Walter Sermeus, Kris Vanhaecht
OBJECTIVES: To study the care pathway effect on the percentage of patients with ST-elevation myocardial infarction -(STEMI) receiving timely coronary reperfusion and the percentage of STEMI patients receiving optimal secondary prevention. METHODS: A care pathway was implemented by the Collaborative Model for Achieving Breakthrough Improvement. One pre-intervention and 2 post-intervention audits included all adult STEMI patients admitted within 24 h after onset and eligible for reperfusion...
August 10, 2018: Cardiology
Xiaoming Jia, Einar Heiberg, Maria Sejersten Ripa, Henrik Engblom, Marcus Carlsson, Sigrun Halvorsen, Håkan Arheden, Dan Atar, Peter Clemmensen, Yochai Birnbaum
The aim of our study was to examine the pathophysiology of ST depression (STD) in leads V1-V3 in the setting of inferior ST elevation myocardial infarction (iSTEMI) through the perspective of cardiac magnetic resonance (CMR). METHODS: Differences in myocardial area at risk (MaR), infarct size, ejection fraction and myocardial segment involvement by CMR were compared in MITOCARE trial patients with first iSTEMI with ST elevation (STE), STD or no ST changes (NST) in V1-V3. The frontal plane projection of the inferior wall MaR in relationship to the anterior/posterior chest wall was calculated and compared between groups...
August 10, 2018: Cardiology
JiaXin Li, Moo Hyun Kim, LongZhe Guo, Kai Song, Eun-Seok Shin, Soe Hee Ann, Soo Jin Kim, Yong-Rak Cho, Kyungil Park, Tae Ho Park, Young Dae Kim, Nikita Lomakin, Victor Serebruany
BACKGROUND: Whether genetic polymorphisms (GP) impact residual platelet aggregation (RPA) following prasugrel is unclear, especially during maintenance phase. We assessed the influence of CYP2C19 GP carriers on RPA in the prospective observational cohort study. METHODS AND RESULTS: All post-stent patients (n = 206) received prasugrel 60 mg loading and either 5 or 10 mg daily maintenance with aspirin100 mg. RPA levels by light transmission aggregometry (LTA), multiplate electrode aggregometry (MEA), and VerifyNow (P2Y12 reaction units, PRU) with CYP2C19 GP were measured simultaneously...
August 9, 2018: Cardiology
Vidar Ruddox, Jan Erik Otterstad, Dan Atar, Bjørn Bendz, Thor Edvardsen
OBJECTIVES: Patients surviving an acute myocardial infarction (AMI) are different today than when oral β-blockers first were shown to have an incremental effect on mortality. They are now, as opposed to then, offered revascularization procedures and effective secondary prevention. In this pilot-study, we aimed to explore the prescription of β-blockers to these patients stratified by their left ventricular ejection fraction (LVEF). METHODS: Consecutive stable patients treated with a percutaneous coronary intervention (PCI) procedure following an AMI were included for measurement of LVEF after 1-5 days...
August 8, 2018: Cardiology
Hymie H Chera, Cristina A Mitre, Justin Nealis, Alex Mironov, Adam S Budzikowski
OBJECTIVES: ST-segment elevation myocardial infarction (STEMI) can be associated with many conduction disturbances including complete atrioventricular block (CAVB). CAVB complicating STEMI resulted in an increased mortality before the modern era of primary percutaneous coronary intervention (PCI). The aim of this study was to ascertain the rate and risk factors for CAVB in STEMI patients undergoing rapid reperfusion with PCI. METHODS: We analyzed 223 patients presenting with STEMI...
July 17, 2018: Cardiology
Nicholas Z Kerin
The pharmacologic treatment of arrhythmias has seen little advance over the past few years. Physicians treating life threatening or hemodynamically destabilizing arrhythmias depend almost entirely on intravenous (IV) amiodarone. This is regrettable due to the multiple toxicities of amiodarone and its long half-life. Once administered, it is a therapeutic commitment to long-term therapy. Given the very long terminal elimination half-life, treatment with amiodarone may interfere with baseline electrophysiologic studies and ablation procedures...
July 17, 2018: Cardiology
Puneet Gandotra
No abstract text is available yet for this article.
July 11, 2018: Cardiology
Juan Zhang, Wen-Shu Zhao, Xin Wang, Lin Xu, Xin-Chun Yang
OBJECTIVE: We investigated the regulation of endothelin-1 (ET-1) expression in in vivo high-fat diet (HFD)-fed mice and in vitro cultured human aortic endothelial cells (HAECs). METHODS: Male C57BL/6 mice were fed on standard chow, serum was prepared, and ET-1 levels were analyzed using an ELISA kit. Quantitative PCR was performed using iQ SYBR Green Supermix. Statistical significance was assessed using SPSS, with p < 0.05 considered significant. RESULTS: The serum ET-1 content and endothelial expression of ET-1 mRNA were increased in the HFD-fed mice compared to the chow-fed control mice...
July 11, 2018: Cardiology
Dimitrios Farmakis, Periklis Davlouros, Gregory Giamouzis, George Giannakoulas, Athanasios Pipilis, Georgios Tsivgoulis, John Parissis
Direct or new oral anticoagulants (NOACs), including the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, have recently revolutionized the field of antithrombotic therapy for stroke and systemic embolism prevention in nonvalvular atrial fibrillation (NVAF). Randomized controlled trials have shown that these agents have at least comparable efficacy with vitamin K antagonists along with superior safety, at least in what concerns intracranial hemorrhage...
2018: Cardiology
Yaron Arbel
No abstract text is available yet for this article.
2018: Cardiology
Matthew J Czarny, Jon R Resar
No abstract text is available yet for this article.
2018: Cardiology
Ramy Abdelfattah, Haroon Kamran, Jason Lazar, John Kassotis
OBJECTIVE: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF. METHODS: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee...
2018: Cardiology
Aws Almufleh, F Daniel Ramirez, Derek So, Michel Le May, Aun-Yeong Chong, Nazi Torabi, Benjamin Hibbert
OBJECTIVES: Mitigating the gastrointestinal (GI) bleeding risks of dual antiplatelet therapy (DAPT) is a common clinical concern. While proton pump inhibitors (PPIs) remain the most effective therapy, their adverse events warrant considering alternatives, including Histamine 2 receptor antagonists (H2RAs). METHODS: We searched for randomized controlled trials in MEDLINE, EMBASE, PubMed, and Cochrane Central Register of Controlled Trials, published from 1980 to 2016...
2018: Cardiology
Adham Elmously, Katherine D Gray, Quynh A Truong, Aaron Burshtein, S Chiu Wong, Andreas R de Biasi, Berhane Worku, Arash Salemi
OBJECTIVES: The role of aortic angulation in attenuating procedural success in balloon-expandable (BE) and self-expandable (SE) transcatheter aortic valve replacement (TAVR) has been controversial. METHODS: We retrospectively assessed patients undergoing SE and BE TAVR who had an aortic angle measured on multidetector computed tomography at a single tertiary referral center. The primary outcome was device success, measured per the Valve Academic Research Consortium-2 criteria...
2018: Cardiology
Jun Huang, Hong-Tao Liao, Hong-Wen Fei, Yu-Mei Xue, Li Zhang, Qiong-Wen Lin, Si-Qi Ren, Xian-Zhang Zhan, Xian-Hong Fang, Mu-Rui Zheng, Shu-Lin Wu, Lin Xu
OBJECTIVES: The aim of the study was to examine the association of CHADS2/CHA2DS2-VASc scores with left atrial thrombus (LAT) and spontaneous echocardiographic contrast (SEC) in non-anticoagulated nonvalvular atrial fibrillation (NVAF) spontaneous patients, and to develop a new scoring system for LAT/SEC prediction. METHODS: Consecutive non-anticoagulated NVAF patients with or without LAT/SEC by transesophageal echocardiography were identified in the Guangdong General Hospital...
2018: Cardiology
Matteo Tebaldi, Simone Biscaglia, Carlo Tumscitz, Annamaria Del Franco, Francesco Gallo, Giosafat Spitaleri, Luca Fileti, Matteo Serenelli, Elisabetta Tonet, Andrea Erriquez, Gianluca Campo, Roberto Ferrari
OBJECTIVE: We sought to demonstrate that the combination of a local vasodilator (verapamil), modern materials, patent hemostasis, and intravenous anticoagulant only in the case of percutaneous coronary intervention, as compared to default heparin administration after sheath insertion, may optimize a combined endpoint, including radial artery oc-clusion (RAO), radial artery spasm (RAS), and access site complication. METHODS: This is a prospective, single-center, double-blind randomized trial...
2018: Cardiology
Konstantinos Dean Boudoulas, Konstantinos Marmagkiolis, Antonios A Pitsis, Harisios Boudoulas
No abstract text is available yet for this article.
2018: Cardiology
Panagiotis G Stamatopoulos, George Dangas, Konstantinos Tsarouhas, George Ziogas, Christina Tsitsimpikou, Georgios Stamatopoulos, George Chrousos
Screening for cardiovascular disease in athletes is crucial to avoid life-threatening complications. Here, we present the case of a fairly asymptomatic young professional soccer player with several cardiovascular risk factors, who proved to have significant coronary artery disease on coronary computed tomography which was ordered based on clinical suspicion and his family history. Informed consent for publication was obtained from the patient.
2018: Cardiology
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
2018: Cardiology
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