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Christina Karazisi, Peter Eriksson, Mikael Dellborg
Congenital coronary artery fistulas are rare anomalies. As coronary angiography and multidetector computed tomography have become more accessible, they have been increasingly used in the investigation of chest pain and heart failure. Coronary artery fistulas are often an incidental finding, which raises the question of how patients with this condition should be managed. Intervention with either transcatheter closure or surgical closure is often technically possible. Many patients are asymptomatic early after closure...
August 30, 2017: Cardiology
Qingshu Wang, Ling Hu, Yu Hu, Gu Gong, Hua Tan, Li Deng, Xiaoqin Sun, Xiaobo Yi, Yangyang Sun, Wei Wu, Tao Li
OBJECTIVE: To investigate the therapeutic effect of carbon monoxide (CO) on high-altitude hypoxia-induced cardiac damage. METHODS: Forty male C57BL/6 mice were randomly divided into 4 groups. The mice were exposed to normoxia or simulated 5,500-meter high-altitude hypoxia in a hypobaric chamber for 7 days. During the first 3 days, the mice were pretreated with CO-saturated hemoglobin (Hb)-based oxygen carrier (CO-HBOC), oxygen-saturated hemoglobin-based oxygen carrier (O2-HBOC) at a dose of 0...
October 12, 2016: Cardiology
Friedrich-Christian Riess, Stefan Heller, Eva Cramer, Nizar Awwad, Wagma Amin, Lorenz Hansen, Claas Lehmann, Joachim Schofer, Jan Stripling, Stephan Winkel, Peter Kremer
BACKGROUND: This is an investigation of complete arterial coronary artery bypass grafting (CACABG) using bilateral internal mammary arteries (IMA) and the T-graft technique either on- or off-pump as a routine approach to treat coronary artery disease. METHODS: Between January 2000 and December 2012, 3,445 patients underwent on-pump (n = 2,216) or off-pump (n = 1,229) CACABG. A 30-day follow-up was performed prospectively, a long-term follow-up by a questionnaire, and coronary angiography in selected patients...
October 4, 2016: Cardiology
Weixian Xu, Haiyi Yu, Hubing Wu, Siheng Li, Baoxia Chen, Wei Gao
OBJECTIVES: To measure plasma catestatin levels in patients with acute coronary syndrome and investigate whether there is an association between catestatin levels and long-term outcome. METHODS: Patients (n = 170) with suspected acute coronary syndrome who underwent emergency coronary angiography were enrolled, including 46 with acute ST-segment elevation myocardial infarction (STEMI), 89 with unstable angina pectoris (UAP), and 35 without coronary artery disease (CAD)...
September 29, 2016: Cardiology
Lu Cao, Lihua Cheng, Jing Xu
No abstract text is available yet for this article.
September 23, 2016: Cardiology
Ines Frederix, Thijs Vandenberk, Leen Janssen, Anne Geurden, Pieter Vandervoort, Paul Dendale
OBJECTIVES: Cardiac telerehabilitation includes, in its most comprehensive format, telemonitoring, telecoaching, social interaction, and eLearning. The specific role of eLearning, however, was seldom assessed. The aim of eEduHeart I is to investigate the medium-term effectiveness of the addition of a cardiac web-based eLearing platform to conventional cardiac care. METHODS: In this prospective, multicenter randomized, controlled trial, 1,000 patients with coronary artery disease will be randomized 1:1 to an intervention group (receiving 1-month unrestricted access to the cardiac eLearning platform in addition to conventional cardiac care) or to conventional cardiac care alone...
September 23, 2016: Cardiology
Charlien Gabriels, Julie De Backer, Agnes Pasquet, Bernard P Paelinck, Marielle Morissens, Frederik Helsen, Alexander Van De Bruaene, Werner Budts
OBJECTIVES: Studies evaluating the long-term outcome of adults with ventricular septal defect (VSD) are important to inform patients about prognosis. This study investigated the long-term outcome of patients with perimembranous VSD (pmVSD) followed in the Belgian Registry on Adult Congenital Heart Disease. METHODS: All pmVSD patients in the registry were analyzed. RESULTS: Two hundred and sixty-six patients were studied. Fifteen patients had Eisenmenger syndrome...
September 21, 2016: Cardiology
Çağın Mustafa Üreyen, Cem Yunus Baş, Şakir Arslan
No abstract text is available yet for this article.
September 13, 2016: Cardiology
Jeffrey S Borer, Karl Swedberg, Michel Komajda, Ian Ford, Luigi Tavazzi, Michael Böhm, Christophe Depre, Yuna Wu, Juan Maya, Fabienne Dominjon
OBJECTIVES: In the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT), slowing of the heart rate with ivabradine reduced cardiovascular death or heart failure hospitalizations among patients with systolic chronic heart failure (CHF). Subsequently, in the Study Assessing the Morbidity-Mortality Benefits of the If Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) slowing of the heart rate in patients without CHF provided no benefit for cardiovascular death or nonfatal myocardial infarction (primary composite end point), with secondary analyses suggesting possible harm in the angina subgroup...
September 10, 2016: Cardiology
Marco Canepa, Pier Luigi Temporelli, Andrea Rossi, Andrea Rossi, Lucio Gonzini, Gian Luigi Nicolosi, Lidia Staszewsky, Roberto Marchioli, Aldo Pietro Maggioni, Luigi Tavazzi
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is a common comorbidity in patients with heart failure (HF). We aimed to assess its prevalence, characterization and long-term prognostic impact in the GISSI-HF population. METHODS: The study randomized 6,975 ambulatory HF patients to either n-3 polyunsaturated fatty acids or placebo. We performed a retrospective analysis of clinical characteristics and outcomes of the 1,533 patients diagnosed with COPD (22%)...
September 8, 2016: Cardiology
Dawn Harris Sherling, Charles H Hennekens
No abstract text is available yet for this article.
September 8, 2016: Cardiology
Shuoyan An, Chaomei Fan, Lirong Yan, Chi Cai, Yinjian Yang, Shanshan Zhai, Shihua Zhao, Yanling Liu, Fujian Duan, Zhimin Wang, Yishi Li
OBJECTIVES: As reported, diagnostic age, gender and presence of outflow tract obstruction have an impact on prognosis in patients with hypertrophic cardiomyopathy. The aim of this study was to compare the long-term outcome between apical hypertrophic cardiomyopathy (ApHCM) and asymmetric septal hypertrophic cardiomyopathy (ASHCM) after the exclusion of these factors. METHODS: A total of 540 patients (270 with ApHCM and 270 with ASHCM) identified in a consecutive single-center cohort were retrospectively studied...
September 6, 2016: Cardiology
Rahul Trikha, Peter R Kowey
OBJECTIVES: Dabigatran, rivaroxaban, apixaban, and edoxaban are nonvitamin K antagonist oral anticoagulants (NOACs) approved for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). Phase-3 clinical trials demonstrated NOACs were as effective as warfarin in the prevention of stroke or systemic embolism and associated with decreased incidences of intracranial bleeding. Additionally, NOACs provide quicker onset of action, simpler dosing, more predictable pharmacokinetic profiles, and decreased food and drug interactions compared with warfarin...
September 6, 2016: Cardiology
Guifang Sun, Fengqi Liu, Renhai Qu
OBJECTIVES: The impact of high thoracic sympathetic block (HTSB) on myocardial fibrosis in chronic heart failure (HF) is unclear. Myocardial collagen synthesis can be assessed by measuring circulating biomarkers. We observed the effect of HTSB on serum collagen biomarkers in HF. METHODS: Forty-four patients were randomized to a control and a HTSB group. They received routine medications. Repeated epidural injections were given to the HTSB group for 4 weeks. Echocardiography and measurements of serum carboxy-terminal propeptide of procollagen type I (PICP) and amino-terminal propeptide of procollagen type III (PIIINP) were performed at baseline and 4 weeks later...
September 3, 2016: Cardiology
Konstantinos Dean Boudoulas, Harisios Boudoulas
No abstract text is available yet for this article.
August 31, 2016: Cardiology
Cecilia Ostman, Daniel Jewiss, Neil A Smart
OBJECTIVES: To establish if exercise training intensity produces different effect sizes for quality of life in heart failure. BACKGROUND: Exercise intensity is the primary stimulus for physical and mental adaptation. METHODS: We conducted a MEDLINE search (1985 to February 2016) for exercise-based rehabilitation trials in heart failure using the search terms 'exercise training', 'left ventricular dysfunction', 'peak VO2', 'cardiomyopathy', and 'systolic heart dysfunction'...
August 27, 2016: Cardiology
Giovanni Di Salvo, Ghassan Siblini, Ziad Issa, Habdan Mohammed, Anas Abu Hazeem, Valeria Pergola, Nisreen Muhanna, Naif Al Qweai, Domenico Galzerano, Bahaa Fadel, Majid Fayyadh, Mansour Joufan, Zohair Halees, Ziad Bulbul
OBJECTIVE: Our aim was to evaluate left ventricular (LV) mechanics by using speckle tracking echocardiography (STE) in asymptomatic patients with abnormal origin of the left main coronary artery from the pulmonary trunk (ALCAPA), late after successful repair, in the presence of LV ejection fraction (EF) >50%. METHODS: We studied 30 ALCAPA patients (median age 4 years, range 1-25 years, NYHA class I, LVEF >50%) and 16 healthy age- and sex-matched controls (median age 5 years, range 1-25 years)...
August 26, 2016: Cardiology
Adam S Budzikowski, Granit Veseli
No abstract text is available yet for this article.
August 26, 2016: Cardiology
David J Milan, J Philip Saul, John C Somberg, Janos Molnar
OBJECTIVES: The role of sotalol is well established for the maintenance of sinus rhythm after successful conversion of atrial fibrillation (AF). However, its role in pharmacologic conversion of AF is poorly defined. The purpose of this study is to compare the efficacy of sotalol to that of other antiarrhythmic agents for AF conversion. METHODS: Standard methods of meta-analysis were employed. Full-text publications of clinical trials in English that compared the efficacy of sotalol to that of other antiarrhythmics or placebo/no treatment were eligible for inclusion...
August 24, 2016: Cardiology
Igal Kushnir, Ido Wolf
Nivolumab, a programmed death 1 (PD1) inhibitor, belongs to a family of drugs known as immune checkpoint inhibitors that share a similar toxicity profile, which includes rash, pruritus, colitis, hepatitis, pneumonitis and thyroid dysfunction. Nivolumab has a proven efficacy in the treatment of malignant melanoma, non-small cell lung cancer and renal cell carcinoma. We present the case of a 67-year-old male patient with metastatic squamous cell carcinoma of the lung who suffered from a massive pericardial effusion secondary to treatment with nivolumab, which he began in June 2015...
August 24, 2016: Cardiology
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