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Asim Katbeh, Tomas Ondrus, Emanuele Barbato, Maurizio Galderisi, Bruno Trimarco, Guy Van Camp, Marc Vanderheyden, Martin Penicka
Patients with severe aortic stenosis (AS) show progressive fibrotic changes in the myocardium, which may impair cardiac function and patient outcomes even after successful aortic valve replacement. Detection of patients who need an early operation remains a diagnostic challenge as myocardial functional changes may be subtle. In recent years, speckle tracking echocardiography (STE) and cardiac magnetic resonance mapping have been shown to provide complementary information for the assessment of left ventricular mechanics and identification of subtle damage by focal or diffuse myocardial fibrosis, respectively...
December 5, 2018: Cardiology
Zubair Shah, Venkat Vuddanda, Aniket S Rali, Hema Pamulapati, Reza Masoomi, Kamal Gupta
AIM: The aim of this study is to report recent trends in the performance of endomyocardial biopsy (EMB) and its in-hospital complications (and their predictors) in the United States (US). METHOD: We analyzed Nationwide Inpatient Sample (NIS) database from years 2007 through 2014 to identify patients who underwent EMB. Once identified, the patients were subdivided into those with no history of heart transplant (HT) (cohort 1) and those with history of HT (cohort 2)...
December 5, 2018: Cardiology
Jubo Jiang, Xianbao Liu, Yuxin He, Qiyuan Xu, Qifeng Zhu, Sanjay Jaiswal, Lihan Wang, Po Hu, Feng Gao, Yinghao Sun, Chunhui Liu, Xiaoping Lin, Jie Liang, Kaida Ren, Jian Apos An Wang
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is a recent and an effective treatment option for high- or extreme-surgical-risk patients with symptomatic severe aortic stenosis. However, pure severe native aortic valve regurgitation (NAVR) without aortic stenosis remains a contraindication to TAVR. The aim of our systemic review analysis was to evaluate TAVR in patients with pure NAVR. METHODS: We searched the published articles in the PubMed and Web of Science databases (2002-2017) using the Boolean operators for studies of NAVR patients undergoing TAVR...
December 5, 2018: Cardiology
Constantine N Antonopoulos, Christos D Liapis
No abstract text is available yet for this article.
November 22, 2018: Cardiology
Kanchi Patel, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
OBJECTIVES: In the course of extensive clinical aortic surgery, we noticed that the aorta was quite thick and fibrotic in diabetic patients. We thought the diabetic aortic aorta might be inimitable to aortic dissection. On this basis, we set out to review information in the literature regarding aortic growth and dissection in diabetic patients. METHODS: We used a 2-step search approach to the available literature on diabetes and aneurysm. Firstly, databases including PubMed, Cochrane, Embase and TRIP were searched...
November 19, 2018: Cardiology
Katerina Fountoulaki, Sotirios Tsiodras, Eftychia Polyzogopoulou, Christophoros Olympios, John Parissis
Influenza and pneumococcal infections have been suggested to be potential risk factors for causing adverse cardiovascular events, especially in high-risk patients. Vaccination against respiratory infections in patients with established cardiovascular disease (CVD) could serve as a potential cost-effective intervention to improve their clinical outcomes and cardiac societies have encouraged it. Previous studies have shown that influenza vaccination reduce mortality, acute coronary syndromes and hospitalization in patients with coronary heart disease (CHD) and/or heart failure (HF)...
November 14, 2018: Cardiology
Yan Gao, Yan Qiu, Jihua Wu, Wei Diao, Haibo Zhang, Siming Wang, Zhiqiang Du, Jun Dong, Mingqiang Zhang, Lixin Jiang
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising target for lowering plasma low-density lipoprotein cholesterol and preventing cardiovascular (CV) disease. Whether plasma PCSK9 measured during the acute phase predicts recurrent CV events in patients with acute myocardial infarction (AMI) remains unresolved. METHODS AND RESULTS: Plasma PCSK9 levels were measured in 1,646 patients with AMI from the China PEACE-Prospective AMI Study at the acute phase...
November 13, 2018: Cardiology
Yanfeng Jiang, Zehan Fan, Yingzhe Wang, Chen Suo, Mei Cui, Ziyu Yuan, Weizhong Tian, Min Fan, Dekun Zhang, Xiaofeng Wang, Li Jin, Weimin Ye, Shuyuan Li, Xingdong Chen
OBJECTIVES: Loss of bone mass may affect the progression of atherosclerosis. We investigated the relationship between low bone mineral density (BMD) and subclinical atherosclerosis in rural China. METHODS: In total, 333 men and 421 postmenopausal women aged 55-65 years were enrolled. BMD was measured in the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Subclinical atherosclerosis was defined as increased carotid artery intima-media thickness (CIMT ≥0...
November 13, 2018: Cardiology
Gaetano Morabito, Cesare Tripolino, Eliezer Joseph Tassone, Placido Grillo, Bindo Missiroli
We report the case of a stent under-expansion due to heavily calcified plaque treated with the shockwave lithoplasty system. A 77-year-old woman underwent coronary angiography, and intravascular ultrasound revealed stent under-expansion due to calcified plaque. Shockwave lithoplasty balloon was used to disrupt calcium deposits around the stent, thereby allowing a correct stent expansion with an excellent angiographic and intravascular ultrasound result.
November 8, 2018: Cardiology
George Lazaros, Maria I Drakopoulou, Dimitris Tousoulis
No abstract text is available yet for this article.
2018: Cardiology
Chris J Kapelios, Maria Bonou, John Barbetseas
No abstract text is available yet for this article.
2018: Cardiology
Efstathios Iliodromitis, Dimitrios Farmakis
No abstract text is available yet for this article.
2018: Cardiology
Xu Hu, Fu-Yao Yang, Yan Wang, Yi Zhang, Mao Chen
OBJECTIVES: Although dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is currently recommended in patients after transcatheter aortic valve implantation (TAVI), this practice is not supported by sufficient evidence. This study was performed to compare DAPT to single antiplatelet therapy (SAPT). METHODS: An electronic search was completed of PubMed, Embase, Ovid Medline, Web of Science, and Cochrane Central Register of Controlled Trials. Studies comparing DAPT versus SAPT in patients undergoing TAVI were included...
2018: Cardiology
Hideyuki Hayashi, Yukio Abe, Yusuke Morita, Eisaku Nakane, Yoshizumi Haruna, Tetsuya Haruna, Moriaki Inoko
BACKGROUND: Large V waves in the pulmonary capillary wedge pressure (PCWP) waveform traditionally indicate severe mitral regurgitation (MR). However, our understanding of MR etiology and hemodynamics has changed in recent decades. OBJECTIVES: We aimed to reevaluate the association between large V waves and current MR to determine whether traditional large V wave criteria remain optimal. METHOD: We reviewed 1,964 right heart catheterizations (RHCs) performed at our institution from 2010 to 2017, and retrospectively selected 126 patients with sinus rhythm who underwent echocardiography within 2 days (0...
2018: Cardiology
Sabine R Zwakenberg, Yvonne T van der Schouw, Cees Vermeer, Gerard Pasterkamp, Hester M den Ruijter, Joline W J Beulens
OBJECTIVE: This study aims to investigate whether plasma matrix Gla protein (MGP) species, desphospho-uncarboxylated (dp-uc) MGP, and total uncarboxylated (t-uc) MGP are associated with plaque levels of uncarboxylated (uc) MGP, markers of plaque stability, and cardiovascular disease (CVD) risk. METHODS: From the Athero-Express biobank, we selected carotid plaque samples of 100 patients who underwent carotid endarterectomy. The level of agreement between plasma MGP species and plaque ucMGP levels was assessed using weighted kappa (κ)...
2018: Cardiology
Dragos Alexandru, Simcha Pollack, Florentina Petillo, J Jane Cao, Eddy Barasch
OBJECTIVES: To substitute the stroke volume index (SVi) with flow rate (FR) in the hemodynamic classification of severe aortic stenosis (AS) with preserved ejection fraction (EF), in order to evaluate its prognostic value. METHODS: A total of 529 patients (78.8 ± 9.8 years old, 44.1% males) with isolated severe AS (aortic valve area, AVA < 1 cm2), EF ≥50%, in sinus rhythm, who underwent transthoracic echocardiography, were stratified by FR (≥/< 200 mL/s) and mean pressure gradient (MG) (≥/< 40 mm Hg): FRnormal/MGhigh, FRlow/MGhigh, FRnormal/MGlow, and FRlow/MGlow...
2018: Cardiology
Ling Sun, Yunjia Tang, Ye Wang, Guanghui Qian, Wenhua Yan, Bo Wang, Xuan Li, Haitao Lv
OBJECTIVES: The purpose of the present study was to explore the changes in epidemiological, clinical and laboratory characteristics of Kawasaki disease (KD) over a 12-year period in this area. METHODS: The medical records of KD patients hospitalized in the Children's Hospital of Soochow University from January 2006 to December 2017 were retrospectively reviewed and analyzed. To elucidate the changes more clearly in these years, we divided all patients into three groups according to the time of admission, 5-year time intervals apart...
2018: Cardiology
Dongyan Hou, Zhenping Fan, Lin Xu, Hua Wang, Zhiyong Zhang, Guiling Ma, Xiaorong Xu, Xin Wang, Juan Zhang, Jiamei Liu, Lin Zhang
BACKGROUND: Autoantibody against M2-muscarinic acetylcholine receptor (anti-M2AChR) has a biological effect similar to a vagus agonist. Digoxin has a function of vagus nervous system stimulation. We hypothesized that anti-M2AChR is highly correlated with digoxin in patients with chronic heart failure (CHF). METHODS: Synthetic M2AChR peptides served as the target antigen in an ELISA were used to screen the sera of 80 CHF patients, who were separated into a negative (-) or positive (+) anti-M2AChR group according to their anti-M2AChR reactivity...
2018: Cardiology
Arismendy Nunez, Sophia Russ, Muhammad Ihsan, Sarah Gaballah, Attiya Haque, Clive Goulbourne, Dale Railwah, Ryan Massay, Muhammad Afzal Khan, Louis Salciccioli, Mark Stewart, Jason M Lazar
BACKGROUND: The low ankle brachial index (ABI) values are indicative of peripheral arterial disease, but have recently been found to be associated with reduced left ventricular ejection fraction (LVEF). This may relate to coexisting coronary artery disease (CAD). AIM: This study prospectively assessed a potential ABI-LVEF association in patients without CAD. METHODS AND RESULTS: We studied 55 patients (age 57 ± 13 years, 49% male) with normal coronary arteries with LVEF determination...
2018: Cardiology
Konstantinos Dean Boudoulas, Filippos Triposkiadis, Harisios Boudoulas
No abstract text is available yet for this article.
2018: Cardiology
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