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Matteo Tebaldi, Simone Biscaglia, Carlo Tumscitz, Annamaria Del Franco, Francesco Gallo, Giosafat Spitaleri, Luca Fileti, Matteo Serenelli, Elisabetta Tonet, Andrea Erriquez, Gianluca Campo, Roberto Ferrari
OBJECTIVE: We sought to demonstrate that the combination of a local vasodilator (verapamil), modern materials, patent hemostasis, and intravenous anticoagulant only in the case of percutaneous coronary intervention, as compared to default heparin administration after sheath insertion, may optimize a combined endpoint, including radial artery oc-clusion (RAO), radial artery spasm (RAS), and access site complication. METHODS: This is a prospective, single-center, double-blind randomized trial...
June 13, 2018: Cardiology
Konstantinos Dean Boudoulas, Konstantinos Marmagkiolis, Antonios A Pitsis, Harisios Boudoulas
No abstract text is available yet for this article.
June 13, 2018: Cardiology
Panagiotis G Stamatopoulos, George Dangas, Konstantinos Tsarouhas, George Ziogas, Christina Tsitsimpikou, Georgios Stamatopoulos, George Chrousos
Screening for cardiovascular disease in athletes is crucial to avoid life-threatening complications. Here, we present the case of a fairly asymptomatic young professional soccer player with several cardiovascular risk factors, who proved to have significant coronary artery disease on coronary computed tomography which was ordered based on clinical suspicion and his family history. Informed consent for publication was obtained from the patient.
June 13, 2018: Cardiology
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
June 6, 2018: Cardiology
Dominik Lautsch, Anselm K Gitt
No abstract text is available yet for this article.
June 6, 2018: Cardiology
Minoru Nodera, Hitoshi Suzuki, Yoshiyuki Matsumoto, Masashi Kamioka, Takashi Kaneshiro, Akiomi Yoshihisa, Tetsuya Ohira, Yasuchika Takeishi
OBJECTIVES: The uric acid (UA) level is related to cardiac events and mortality, but little is known about the clinical significance of serum UA with regard to the ventricular tachyarrhythmia (VT) risk in patients with heart failure. METHODS: The present study enrolled 56 patients with ischemic and nonischemic cardiomyopathy (37 males, mean age 64.7 ± 11.1 years) who received prophylactic implantable cardioverter-defibrillator (ICD) implantation. Based on a median serum UA value, study subjects were divided into two groups: serum UA < 6...
May 25, 2018: Cardiology
Andrew Xanthopoulos, Randall C Starling, Filippos Triposkiadis
No abstract text is available yet for this article.
May 17, 2018: Cardiology
Tisa Saha, Syed Yaseen Naqvi, Sheldon Goldberg
Hybrid coronary revascularization (HCR) combines surgical bypass with percutaneous coronary intervention (PCI) performed either during the same procedure or in a staged approach within 60 days. Coronary artery bypass grafting using the left internal mammary artery (LIMA) has shown excellent long-term patency with improved patient survival. It remains the gold standard treatment for the majority of patients with multivessel coronary artery disease. However, saphenous vein grafts have poor long-term patency. Advances in stent technology have resulted in reduced rates of thrombosis and restenosis, making PCI a viable alternative to coronary surgery in selected patients...
May 7, 2018: Cardiology
Björn W Karlson, Stephen J Nicholls, Pia Lundman, Philip J Barter, Michael K Palmer
OBJECTIVE: We used individual patient data from the VOYAGER database to estimate cardiovascular (CV) risk reduction with commonly used high-intensity statins. METHODS: In patients with known atherosclerotic CV disease (ASCVD) treated with high-intensity statin therapy (n = 6,735), the predicted risk reduction was estimated using the Cholesterol Treatment Trialists' Collaboration meta-analysis, which determined risk reduction per 38.7 mg/dL statin-mediated reduction in low-density lipoprotein cholesterol...
April 27, 2018: Cardiology
In-Jeong Cho, Soo-Jin Kim, Donghee Han, Darae Kim, Chi Young Shim, Geu-Ru Hong, Hyuk-Jae Chang
BACKGROUND: We aimed to investigate the characteristics and echocardiographic changes in patients with severe mitral stenosis (MS) who maintained sinus rhythm (SR) for at least 10 years after successful percutaneous mitral balloon valvuloplasty (PMV). METHODS: We retrospectively reviewed 107 patients who had successful PMV and follow-up echocardiography for at least 10 years without mitral valve surgery. Preprocedural, immediate postprocedural (PMV), and long-term follow-up echocardiography (at least 10 years after PMV) data were reviewed...
April 12, 2018: Cardiology
Kai Yu, Xiao-Juan Bai, Bo Jin, Xin Zhao, Lu-Lu Han, Wei-Guang Zhang
PURPOSE: To explore the relationship between central blood pressure (BP) parameters and cardiac structure and function parameters in healthy individuals. METHODS: Four hundred Chinese participants with no overt cardiovascular disease participated in this study. One hundred and seventy-one participants (42.8%) were male and the mean age was 60 years. Central BP was measured with the SphygmoCor system. Cardiac structure and function were assessed by echocardiography...
April 10, 2018: Cardiology
Suli Zhang, Jinhang Zhu, Hua Li, Lei Wang, Jiamin Niu, Bin Zhu, Lin He, Lu Shen, Shengying Qin, Shuxin Fang
OBJECTIVES: Genetic variation is thought to contribute to considerable interindividual variability in platelet function, and there is a pressing need to identify genetic markers that can be used to predict the response to treatment. Our study investigated whether PEAR1, P2Y12, and UGT2A1 polymorphisms were associated with platelet reactivity in response to dual antiplatelet therapy in Chinese patients with acute coronary syndrome. METHODS: Patients with inhibition of platelet aggregation (IPA) < 30% after treatment were classified as the high platelet reactivity (HPR) group...
April 10, 2018: Cardiology
Kim Boddum, Arnela Saljic, Thomas Jespersen, Alex Hørby Christensen
A variety of life-threating arrhythmias are caused by mutations in the cardiac voltage-gated sodium channel encoded by the SCN5A gene. In this study, we report a novel loss-of-function SCN5A variant, p.Ile1343Val (c.4027A>G), identified in a 42-year-old proband who presented with an unusual ECG with abnormal repolarization with biphasic T-waves in anteroseptal leads, persistent atrial fibrillation (AF), intermittent left bundle branch block (LBBB), and reversible cardiomyopathy. The patient did not meet the diagnostic criteria for Brugada syndrome, long QT syndrome, or any other known SCN5A-associated phenotype...
April 10, 2018: Cardiology
Wei Cai, Yan Dong, Lu Tian, Chun-Xia Cao, Xiu-Long Niu, Xin-Lin Liu, Jun-Xiang Liu, Wen-Jie Ji, Zhuoli Zhang, Xin Zhou, Yu-Ming Li
OBJECTIVES: To investigate the predictive value of four-dimensional (4D) strain echocardiography for major adverse cardiovascular events (MACE) in ST-elevation acute myocardial infarction (STEMI) patients. METHODS: Consecutive STEMI patients who underwent successful primary coronary interven tion (PCI) were enrolled and followed, with 2D and 4D strain echocardiography performed within 1 week after PCI. RESULTS: Twenty-six first MACE were recorded in 81 patients who finished a ∼3...
2018: Cardiology
Jeffrey S Borer
No abstract text is available yet for this article.
2018: Cardiology
Ni Yang, Xiao-Lu Shi, Bing-Lun Zhang, Jian Rong, Tie-Ning Zhang, Wei Xu, Chun-Feng Liu
Septic shock with low cardiac output is very common in children. However, the mechanism underlying myocardial depression is unclear. The role of β3-AR in the development of myocardial depression in sepsis is unknown. In the present study, we generated an adolescent rat model of hypodynamic septic shock induced by lipopolysaccharide (LPS). Neonatal cardiomyocytes were also treated with LPS to mimic myocardial depression in sepsis, which was confirmed via an in vivo left ventricular hemodynamic study, and measurements of contractility and the Ca2+ transient in isolated adolescent and neonatal cardiomyocytes...
2018: Cardiology
Jie Fu, Yiwei Chen, Fen Li
BACKGROUND: The effect of microRNA (miR)-495 on cardiomyocyte hypertrophy was explored by investigating the expression of proteins in the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway. METHODS: The study used a rat model of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT) administration (60 mg/kg) for 2 weeks. Arterial wall thickness and right ventricular hypertrophy were examined by hematoxylin and eosin (HE) staining in the lungs and hearts...
2018: Cardiology
Masaru Hiki, Hiroshi Iwata, Yuko Kawaguchi, Kazuhisa Takamura, Makoto Hiki, Tetsuro Miyazaki, Shinichiro Fujimoto, Atsushi Amano, Hiroyuki Daida
A giant right coronary artery aneurysm (60 × 70 mm in size) was incidentally found by chest X-ray as an abnormal right atrial enlargement, and it needed surgical resection. Although the majority of giant coronary artery aneurysms present with symptoms of coronary ischemia, this case presented without any specific symptom. This study indicates that when chest X-ray shows abnormal atrial enlargement, a differential diagnosis of giant coronary artery aneurysm may need to be considered.
2018: Cardiology
Christoph Gräni, Dominik C Benz, Dominik A Steffen, Andreas A Giannopoulos, Michael Messerli, Aju P Pazhenkottil, Oliver Gaemperli, Cathérine Gebhard, Christian Schmied, Philipp A Kaufmann, Ronny R Buechel
OBJECTIVES: Recommendations regarding sports restriction are lacking for middle-aged athletes with anomalous coronary arteries originating from the opposite sinus of Valsalva (ACAOS). METHODS: Sixty-three patients with ACAOS were subdivided into ACAOS with (n = 38) or without (n = 25) an interarterial course (IAC). Sports behavior, either competitive (COMP) or recreational (REC), was evaluated at the time of diagnosis and after a median follow-up of 4.2 years. RESULTS: Mean age was 56 ± 11 years and 48 (76...
2018: Cardiology
Yun Shen, Xueli Zhang, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
OBJECTIVES: To investigate whether serum fibroblast growth factor 21 (FGF21) levels can be used to predict the future development of major adverse cardiovascular events (MACEs). METHODS: This study included 253 patients who received subsequent follow-up, and complete data were collected for 234 patients. Independent predictors of MACEs were identified by using the Cox proportional-hazards regression analysis. The prognostic value of FGF21 levels for MACEs was evaluated by Kaplan-Meier survival analysis...
2018: Cardiology
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