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Biomedizinische Technik. Biomedical Engineering

Jan Osmers, Michael Sorg, Andreas Fischer
Motivation Glaucoma is currently the most common irreversible cause of blindness worldwide. A significant risk factor is an individually increased intraocular pressure (IOP). A precise measurement method is needed to determine the IOP in order to support the diagnosis of the disease and to monitor the outcome of the IOP reduction as a medical intervention. A handheld device is under development with which the patient can perform self-measurements outside the clinical environment. Method For the measurement principle of the self-tonometer the eye is acoustically excited to oscillate, which is analyzed and attributed to the present IOP...
September 19, 2018: Biomedizinische Technik. Biomedical Engineering
Nurul Salwani Mohamad Saadon, Nur Azah Hamzaid, Nazirah Hasnan, Muhammad Afiq Dzulkifli, Glen M Davis
Repetitive electrically-evoked muscle contraction leads to accelerated muscle fatigue. This study assessed electrically-evoked fatiguing muscle with changes to mechanomyography root mean square percentage (%RMS-MMG) and tissue saturation index (%TSI) in extensor carpi radialis. Forty healthy volunteers (n=40) performed repetitive electrical-evoked wrist extension to fatigue and results were analyzed pre- and post-fatigue, i.e. 50% power output (%PO) drop. Responses of %PO, %TSI and %RMS-MMG were correlated while the relationships between %RMS-MMG and %TSI were investigated using linear regression...
September 19, 2018: Biomedizinische Technik. Biomedical Engineering
ChangMin Choi, Se-Han Lee, DongGeon Lee, SoungKyun Hong, SeungHyeon Pyo, SuHo Park, Kyeongbong Lee, GyuChang Lee
The elderly population in many countries has been rising rapidly, and falls are a serious event many elderly people experience. Assistive equipment is actively used to reduce falls among elderly people. Popular types of assistive equipment include canes, electric wheelchairs, and wheeled walkers. Wheeled walkers support the body of elderly people, making their gait comfortable as they age or recover from injuries. Wheeled walkers may be equipped with hand brakes; however, frail older people may experience difficulty using such hand brakes, as they require force to operate...
September 19, 2018: Biomedizinische Technik. Biomedical Engineering
Birgit Huber, Eva Hoch, Iván Calderon, Kirsten Borchers, Petra J Kluger
Size and function of bioartificial tissue models are still limited due to the lack of blood vessels and dynamic perfusion for nutrient supply. In this study, we evaluated the use of cytocompatible methacryl-modified gelatin for the fabrication of a hydrogel-based tube by dip-coating and subsequent photo-initiated cross-linking. The wall thickness of the tubes and the diameter were tuned by the degree of gelatin methacryl-modification and the number of dipping cycles. The dipping temperature of the gelatin solution was adjusted to achieve low viscous fluids of approximately 0...
September 18, 2018: Biomedizinische Technik. Biomedical Engineering
Wenke Markgraf, Philipp Feistel, Christine Thiele, Hagen Malberg
The lack of donor grafts is a severe problem in transplantation medicine. Hence, the improved preservation of existing and the usage of organs that were deemed untransplantable is as urgent as ever. The development of novel preservation techniques has come into focus. A promising alternative to traditional cold storage is normothermic machine perfusion (NMP), which provides the benefit of improving the organs' viability and of assessing the organs' status under physiological conditions. For this purpose, methods for evaluating organ parameters have yet to be developed...
September 15, 2018: Biomedizinische Technik. Biomedical Engineering
Claudia Sicher, Rico Rutkowski, Stine Lutze, Sebastian von Podewils, Thomas Wild, Markus Kretching, Georg Daeschlein
There is a lack of imaging tools for the evaluation of spatial alterations in microcirculation including blood oxygen saturation and hemoglobin distribution but recent innovative developments in hyperspectral technology may offer a solution. We examined different hemodynamic disorders in patients suffering from scleroderma, Dupuytren surgery, chronic foot ulcera and skin infections. Superficial and deeper blood oxygen saturation, hemoglobin distribution and water content were determined using hyperspectral imaging (HSI)...
September 13, 2018: Biomedizinische Technik. Biomedical Engineering
Bennet Hensen, Urte Kägebein, Marcel Gutberlet, Kristina I Ringe, Van Dai Vo-Chieu, Daniel Stucht, Oliver Speck, Ralf Vick, Frank Wacker, Enrico Pannicke
No abstract text is available yet for this article.
September 6, 2018: Biomedizinische Technik. Biomedical Engineering
Steffi Grohmann, Manuela Menne, Diana Hesse, Sabine Bischoff, René Schiffner, Michael Diefenbeck, Klaus Liefeith
No abstract text is available yet for this article.
September 3, 2018: Biomedizinische Technik. Biomedical Engineering
Florian Tetschke, Lars Kirsten, Jonas Golde, Julia Walther, Roberta Galli, Edmund Koch, Christian Hannig
No abstract text is available yet for this article.
August 25, 2018: Biomedizinische Technik. Biomedical Engineering
Muhammad Noor-Ul-Huda, Samabia Tehsin, Sairam Ahmed, Fuad A K Niazi, Zeerish Murtaza
Diabetes mellitus is an enduring disease related with significant morbidity and mortality. The main pathogenesis behind this disease is its numerous micro- and macrovascular complications. In developing countries, diabetic retinopathy (DR) is one of the major sources of vision impairment in working age population. DR has been classified into two categories: proliferative diabetic retinopathy (PDR) and non-proliferative diabetic retinopathy (NPDR). NPDR is further classified into mild, moderate and severe, while PDR is further classified into early PDR, high risk PDR and advanced diabetic eye disease...
July 28, 2018: Biomedizinische Technik. Biomedical Engineering
T Rajalakshmi, Shanthi Prince
The physiological modeling of retinal layers to provide an insight into how the incoming image is converted into its equivalent spike train that can be decoded by the human brain is a key issue. Most of the retinal layer models concentrate mainly on image compression, edge detection and image reconstruction. A retinal layer model to generate spike waveform corresponding to the visual information is not covered much in the literature. The aim of this study was to develop a mathematical model of retinal layers that has complex neural structures, that can detect the incoming signal and transform the signal into the equivalent spike train...
July 28, 2018: Biomedizinische Technik. Biomedical Engineering
Song Ma, Guan Wang, Liubin Li, Yuhua Cheng
Oscillometry is the most popular technique for automatic blood pressure (BP) estimation. This method relies on recording the cuff deflation curve (CDC) from a high suprasystolic BP (SSBP) to a low subdiastolic BP (SDBP) and is very sensitive to noise caused by breathing, motion artifacts, muscle contraction and the environment. We developed a unified BP estimation method involving two integrated sub-procedures based on the arterial lumen area (ALA) model and applied it for continuous BP measurement. Our proposed method is coefficient free and continuous...
July 27, 2018: Biomedizinische Technik. Biomedical Engineering
Amadeus Holmer, Jörg Marotz, Philip Wahl, Michael Dau, Peer W Kämmerer
Blood perfusion is the supply of tissue with blood, and oxygen is a key factor in the field of minor and major wound healing. Reduced perfusion of a wound bed or transplant often causes various complications. Reliable methods for an objective evaluation of perfusion status are still lacking, and insufficient perfusion may remain undiscovered, resulting in chronic processes and failing transplants. Hyperspectral imaging (HSI) represents a novel method with increasing importance for clinical practice. Therefore, methods, software and algorithms for a new HSI system are presented which can be used to observe tissue oxygenation and other parameters that are of importance in supervising healing processes...
July 20, 2018: Biomedizinische Technik. Biomedical Engineering
Taha Haddadifam, Mohammad Azim Karami
Digital silicon photomultiplier (dSiPM) is introduced for diffuse optical imaging (DOI) applications instead of conventional photomultiplier tubes and avalanche photodiodes (APDs) as a state-of-the-art detector. According to the low-level light regime in DOI applications, high sensitivity and high dynamic range (DR) image sensors are needed for DOI systems. dSiPM is proposed as a developing detector which can detect low-level lights. Also, an accurate equation is obtained for calculating the DR of dSiPMs. Different dSiPMs and the corresponding benefits are studied for DOI applications...
July 12, 2018: Biomedizinische Technik. Biomedical Engineering
Axel Boese, Philipp Hündorf, Christoph Arens, Daniel T Friedrich, Michael Friebe
Purpose For the treatment of malignant diseases of the oral cavity and the larynx, a total or partial resection is the standard therapy, while in special cases chemo- and/or external radiation therapy is considered. Transoral access reduces trauma and hospitalization time. Transoral surgery is usually executed using external microscopic imaging. Therefore, the microscope is placed in the visual line of the opening of the mouth and throat. However, specific anatomical structures like the posterior commissure (dorsal end of the vocal cords) are not visible in these procedures...
July 12, 2018: Biomedizinische Technik. Biomedical Engineering
Beibei Zhang, Ning Bi, Chao Zhang, Xiangping Gao, Zhao Lv
Human activity recognition (HAR) is a research hotspot in the field of artificial intelligence and pattern recognition. The electrooculography (EOG)-based HAR system has attracted much attention due to its good realizability and great application potential. Focusing on the signal processing method of the EOG-HAR system, we propose a robust EOG-based saccade recognition using the multi-channel convolutional independent component analysis (ICA) method. To establish frequency-domain observation vectors, short-time Fourier transform (STFT) is used to process time-domain EOG signals by applying the sliding window technique...
July 5, 2018: Biomedizinische Technik. Biomedical Engineering
Michael Czaplik, Mark Ulbrich, Nadine Hochhausen, Rolf Rossaint, Steffen Leonhardt
The gold standard for estimating blood alcohol content (BAC) after alcohol consumption is a blood sample analysis. An innovative technology to estimate BAC is based on impedance cardiography and bioimpedance spectroscopy (BIS). This study investigated whether it is possible to estimate increasing blood alcohol levels during a drinking trial with bioimpedance measurement techniques. Twenty-one healthy volunteers were assigned to a test (ethanol) group (ETH) or a reference group (H2O). After baseline measurements, the ETH group ingested 120 ml of vodka, followed by a resorption phase of 50 min...
June 27, 2018: Biomedizinische Technik. Biomedical Engineering
Randy E S Harnarinesingh, Chanan S Syan
Brain-computer interface (BCI) applications such as keyboard control and vehicular navigation present significant assistive merit for disabled individuals. However, there are limitations associated with BCI paradigms which restrict a wider adoption of BCI technology. For example, rapid serial visual presentation (RSVP) paradigms can induce seizures in photosensitive epileptic subjects. This paper evaluates the novel mirrored-word reading paradigm (MWRP) for BCI implementation using an offline experimental study...
June 27, 2018: Biomedizinische Technik. Biomedical Engineering
Quentin Péntek, Simon Hein, Arkadiusz Miernik, Alexander Reiterer
Bladder cancer is likely to recur after resection. For this reason, bladder cancer survivors often undergo follow-up cystoscopy for years after treatment to look for bladder cancer recurrence. 3D modeling of the bladder could provide more reliable cystoscopic documentation by giving an overall picture of the organ and tumor positions. However, 3D reconstruction of the urinary bladder based on endoscopic images is challenging. This is due to the small field of view of the endoscope, considerable image distortion, and occlusion by urea, blood or particles...
July 26, 2018: Biomedizinische Technik. Biomedical Engineering
Katharina Olze, Christof Jan Wehrmann, Luyang Mu, Meinhard Schilling
In brain computer interface (BCI) applications, the use of steady-state visually evoked potentials (SSVEPs) is common. Therefore, a visual stimulation with a constant repetition frequency is necessary. However, using a computer monitor, the set of frequencies that can be used is restricted by the refresh rate of the screen. Frequencies that are not an integer divisor of the refresh rate cannot be displayed correctly. Furthermore, the programming language the stimulation software is written in and the operating system influence the actually generated and presented frequencies...
July 26, 2018: Biomedizinische Technik. Biomedical Engineering
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