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Biomedizinische Technik. Biomedical Engineering

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https://www.readbyqxmd.com/read/28306515/decentralized-safety-concept-for-closed-loop-controlled-intensive-care
#1
Jan Kühn, Christian Brendle, André Stollenwerk, Martin Schweigler, Stefan Kowalewski, Thorsten Janisch, Rolf Rossaint, Steffen Leonhardt, Marian Walter, Rüdger Kopp
This paper presents a decentralized safety concept for networked intensive care setups, for which a decentralized network of sensors and actuators is realized by embedded microcontroller nodes. It is evaluated for up to eleven medical devices in a setup for automated acute respiratory distress syndrome (ARDS) therapy. In this contribution we highlight a blood pump supervision as exemplary safety measure, which allows a reliable bubble detection in an extracorporeal blood circulation. The approach is validated with data of animal experiments including 35 bubbles with a size between 0...
March 17, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28306517/biomechanical-analysis-of-stiffness-and-fracture-displacement-after-using-pmma-augmented-sacroiliac-screw-fixation-for-sacrum-fractures
#2
Andreas Höch, Richard Schimpf, Niels Hammer, Stefan Schleifenbaum, Michael Werner, Christoph Josten, Jörg Böhme
Cement augmentation of pedicle screws is the gold standard for the stabilization of osteoporotic fractures of the spine. In-screw cement augmentation, in which cement is injected through the cannula, is another option for fracture stabilization of fragility fractures of the sacrum. However, biomechanical superiority of this technique compared to conventional sacroiliac screw fixation has not been tested. The present study compares the stability of cement-augmented and non-cement-augmented sacroiliac screw fixation in osteoporotic sacrum fractures under cyclic loading...
March 15, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28306516/identification-and-classification-of-upper-limb-motions-using-pca
#3
Karan Veer, Renu Vig
This paper describes the utility of principal component analysis (PCA) in classifying upper limb signals. PCA is a powerful tool for analyzing data of high dimension. Here, two different input strategies were explored. The first method uses upper arm dual-position-based myoelectric signal acquisition and the other solely uses PCA for classifying surface electromyogram (SEMG) signals. SEMG data from the biceps and the triceps brachii muscles and four independent muscle activities of the upper arm were measured in seven subjects (total dataset=56)...
March 15, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28259865/parametrization-of-an-in-silico-circulatory-simulation-by-clinical-datasets-towards-prediction-of-ventricular-function-following-assist-device-implantation
#4
Ajay Moza, Jonas Gesenhues, Rüdiger Autschbach, Dirk Abel, Rolf Rossaint, Thomas Schmitz-Rode, Andreas Goetzenich
BACKGROUND: Left ventricular assist device (LVAD) therapy has revolutionized the way end stage heart failure is treated today. Analysis of LVAD interaction with the whole cardiovascular system and its biological feedback loops is often conducted by means of computer models. Generating real time pressure volume loops (PV-loops) in patients, not using conductance catheters but routine diagnostics to feed an in-silico model could help to predict postoperative complications. METHODS: Routinely obtained hemodynamic measurements to evaluate myocardial function prior to LVAD implantation like pressure readings in the aorta, the left atrium and the left ventricle and simultaneous three-dimensional (3D) echocardiography recordings were assessed to parametrize a reduced computational model of the cardiovascular system...
March 6, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28258973/rapid-automated-mosaicking-of-the-human-corneal-subbasal-nerve-plexus
#5
Yash J Vaishnav, Stuart A Rucker, Keshav Saharia, Nancy A McNamara
Corneal confocal microscopy (CCM) is an in vivo technique used to study corneal nerve morphology. The largest proportion of nerves innervating the cornea lie within the subbasal nerve plexus, where their morphology is altered by refractive surgery, diabetes and dry eye. The main limitations to clinical use of CCM as a diagnostic tool are the small field of view of CCM images and the lengthy time needed to quantify nerves in collected images. Here, we present a novel, rapid, fully automated technique to mosaic individual CCM images into wide-field maps of corneal nerves...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28258972/design-of-a-mechanism-for-converting-the-energy-of-knee-motions-by-using-electroactive-polymers
#6
Pascal Armbruster, Yannick Oster, Marcel Vogt, Christian Pylatiuk
Harvesting energy from human body motions has become a promising option to prolong battery life for powering medical devices for autonomy. Up to now, different generating principles including dielectric electroactive polymers (DEAPs) have been suggested for energy conversion. However, there is a lack of mechanisms that are specifically designed to convert energy with DEAPs. In a proof of concept study, a mechanical system was designed for stretching DEAPs in those phases of the gait cycle, in which the muscles mainly perform negative work...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28258971/an-image-processing-strategy-to-extract-important-information-suitable-for-a-low-size-stimulus-pattern-in-a-retinal-prosthesis
#7
Yili Chen, Jixiang Fu, Dawei Chu, Rongmao Li, Yaoqin Xie
BACKGROUND: A retinal prosthesis is designed to help the blind to obtain some sight. It consists of an external part and an internal part. The external part is made up of a camera, an image processor and an RF transmitter. The internal part is made up of an RF receiver, implant chip and microelectrode. METHODS: Currently, the number of microelectrodes is in the hundreds, and we do not know the mechanism for using an electrode to stimulate the optic nerve. A simple hypothesis is that the pixels in an image correspond to the electrode...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28222012/effects-of-the-nasal-passage-on-forced-oscillation-lung-function-measurements
#8
Chuong Ngo, Karl Krüger, Thomas Vollmer, Stefan Winter, Bernhard Penzlin, Sylvia Lehmann, Steffen Leonhardt, Berno Misgeld
The forced oscillation technique (FOT) is a non-invasive pulmonary function test which is based on the measurement of respiratory impedance. Recently, promising results were obtained by the application of FOT on patients with respiratory failure and obstructive sleep apnea (OSA). By using a nasal mask instead of a mouthpiece, the influences of the nasal passage and upper shunt alter the measured mechanical impedance. In this paper, we investigated the effects of the nasal passage and mask on FOT measurements from eight healthy subjects...
February 21, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28222011/automatic-sleep-stage-classification-of-single-channel-eeg-by-using-complex-valued-convolutional-neural-network
#9
Junming Zhang, Yan Wu
Many systems are developed for automatic sleep stage classification. However, nearly all models are based on handcrafted features. Because of the large feature space, there are so many features that feature selection should be used. Meanwhile, designing handcrafted features is a difficult and time-consuming task because the feature designing needs domain knowledge of experienced experts. Results vary when different sets of features are chosen to identify sleep stages. Additionally, many features that we may be unaware of exist...
February 21, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28182575/response-of-a-physiological-controller-for-ventricular-assist-devices-during-acute-patho-physiological-events-an-in-vitro-study
#10
Anastasios Petrou, Panagiotis Pergantis, Gregor Ochsner, Raffael Amacher, Thomas Krabatsch, Volkmar Falk, Mirko Meboldt, Marianne Schmid Daners
The current paper analyzes the performance of a physiological controller for turbodynamic ventricular assist devices (tVADs) during acute patho-physiological events. The numerical model of the human blood circulation implemented on our hybrid mock circulation was extended in order to simulate the Valsalva maneuver (VM) and premature ventricular contractions (PVCs). The performance of an end-diastolic volume (EDV)-based physiological controller for VADs, named preload responsive speed (PRS) controller was evaluated under VM and PVCs...
February 9, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28182574/rapidnam-generative-manufacturing-approach-of-nasoalveolar-molding-devices-for-presurgical-cleft-lip-and-palate-treatment
#11
Franz Xaver Bauer, Markus Schönberger, Johannes Gattinger, Markus Eblenkamp, Erich Wintermantel, Andrea Rau, Florian Dieter Güll, Klaus-Dietrich Wolff, Denys J Loeffelbein
Nasoalveolar molding (NAM) is an accepted treatment strategy in presurgical cleft therapy. The major drawbacks of the treatment listed in the literature relate to the time of the treatment and the coordination of the required interdisciplinary team of therapists, parents, and patients. To overcome these limitations, we present the automated RapidNAM concept that facilitates the design and manufacturing process of NAM devices, and that allows the virtual modification and subsequent manufacture of the devices in advance, with a growth prediction factor adapted to the patient's natural growth...
February 9, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28157689/differential-mineralization-of-human-dental-pulp-stem-cells-on-diverse-polymers
#12
Christian Apel, Patricia Buttler, Jochen Salber, Anandhan Dhanasingh, Sabine Neuss
In tissue engineering, biomaterials are used as scaffolds for spatial distribution of specific cell types. Biomaterials can potentially influence cell proliferation and extracellular matrix formation, both in positive and negative ways. The aim of the present study was to investigate and compare mineralized matrix production of human dental pulp stem cells (DPSC), cultured on 17 different well-characterized polymers. Osteogenic differentiation of DPSC was induced for 21 days on biomaterials using dexamethasone, L-ascorbic-acid-2-phosphate, and sodium β-glycerophosphate...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28157688/pattern-recognition-of-enrichment-levels-of-selex-based-candidate-aptamers-for-human-c-reactive-protein
#13
Xinliang Yu, Ruqin Yu, Xiaohai Yang
Selecting aptamers for human C-reactive protein (CRP) would be of critical importance in predicting the risk for cardiovascular disease. The enrichment level of DNA aptamers is an important parameter for selecting candidate aptamers for further affinity and specificity determination. This paper is the first report on pattern recognition used for CRP aptamer enrichment levels in the systematic evolution of ligands by exponential enrichment (SELEX) process, by applying structure-activity relationship models. After generating 10 rounds of graphene oxide (GO)-SELEX and 1670 molecular descriptors, eight molecular descriptors were selected and five latent variables were then obtained with principal component analysis (PCA), to develop a support vector classification (SVC) model...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28121615/physiological-closed-loop-control-of-mechanical-ventilation-and-extracorporeal-membrane-oxygenation
#14
Christian Brendle, Thorsten Mülders, Jan Kühn, Thorsten Janisch, Rüdger Kopp, Rolf Rossaint, Andre Stollenwerk, Stefan Kowalewski, Berno Misgeld, Steffen Leonhardt, Marian Walter
A new concept is presented for cooperative automation of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) therapy for treatment of acute respiratory distress syndrome (ARDS). While mechanical ventilation is continuously optimized to promote lung protection, extracorporeal gas transfer rates are simultaneously adjusted to control oxygen supply and carbon dioxide removal using a robust patient-in-the-loop control system. In addition, the cooperative therapy management uses higher-level algorithms to adjust both therapeutic approaches...
January 25, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28121614/benefits-of-object-oriented-models-and-modelichart-modern-tools-and-methods-for-the-interdisciplinary-research-on-smart-biomedical-technology
#15
Jonas Gesenhues, Marc Hein, Maike Ketelhut, Moriz Habigt, Daniel Rüschen, Mare Mechelinck, Thivaharan Albin, Steffen Leonhardt, Thomas Schmitz-Rode, Rolf Rossaint, Rüdiger Autschbach, Dirk Abel
Computational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined...
January 25, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28110313/framework-for-2d-3d-image-fusion-of-infrared-thermography-with-preoperative-mri
#16
Nico Hoffmann, Florian Weidner, Peter Urban, Tobias Meyer, Christian Schnabel, Yordan Radev, Gabriele Schackert, Uwe Petersohn, Edmund Koch, Stefan Gumhold, Gerald Steiner, Matthias Kirsch
Multimodal medical image fusion combines information of one or more images in order to improve the diagnostic value. While previous applications mainly focus on merging images from computed tomography, magnetic resonance imaging (MRI), ultrasonic and single-photon emission computed tomography, we propose a novel approach for the registration and fusion of preoperative 3D MRI with intraoperative 2D infrared thermography. Image-guided neurosurgeries are based on neuronavigation systems, which further allow us track the position and orientation of arbitrary cameras...
January 23, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28099115/examination-of-the-reliability-of-an-inertial-sensor-based-gait-analysis-system
#17
Katja Orlowski, Falko Eckardt, Fabian Herold, Norman Aye, Jürgen Edelmann-Nusser, Kerstin Witte
Gait analysis is an important and useful part of the daily therapeutic routine. InvestiGAIT, an inertial sensor-based system, was developed for using in different research projects with a changing number and position of sensors and because commercial systems do not capture the motion of the upper body. The current study is designed to evaluate the reliability of InvestiGAIT consisting of four off-the-shelf inertial sensors and in-house capturing and analysis software. Besides the determination of standard gait parameters, the motion of the upper body (pelvis and spine) can be investigated...
January 18, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076297/dynamics-of-the-cardiovascular-autonomic-regulation-during-orthostatic-challenge-is-more-relaxed-in-women
#18
Sina Reulecke, Sonia Charleston-Villalobos, Andreas Voss, Ramón González-Camarena, Jesús González-Hermosillo, Mercedes Gaitán-González, Guadalupe Hernández-Pacheco, Rico Schroeder, Tomás Aljama-Corrales
Linear dynamic analysis of cardiovascular and respiratory time series was performed in healthy subjects with respect to gender by shifted short-term segments throughout a head-up tilt (HUT) test. Beat-to-beat intervals (BBI), systolic (SYS) and diastolic (DIA) blood pressure and respiratory interval (RESP) time series were acquired in 14 men and 15 women. In time domain (TD), the descending slope of the auto-correlation function (ACF) (BBI_a31cor) was more pronounced in women than in men (p<0.05) during the HUT test and considerably steeper (p<0...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076296/efficiency-test-of-current-carotid-embolic-protection-devices
#19
Anja Kurzhals, Jörn-Bo Matthies, Reimer Andresen, Christian Wissgott, Klaus-Peter Schmitz, Niels Grabow, Wolfram Schmidt
Embolic protection devices were developed to reduce the risk of stroke during carotid artery stenting. The aim of this study was to test the capture efficiency of five embolic protection devices under reproducible in vitro conditions. The setup consisted of silicone tubes representing the vessel modeling round and oval cross sections. Spherical polystyrene particles (150 μm, COOH-coating) were used to simulate the plaque. The particles were inserted in a clean water circuit and either captured by the device or collected in a glass filter...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076295/convolutive-blind-source-separation-of-surface-emg-measurements-of-the-respiratory-muscles
#20
Eike Petersen, Herbert Buchner, Marcus Eger, Philipp Rostalski
Electromyography (EMG) has long been used for the assessment of muscle function and activity and has recently been applied to the control of medical ventilation. For this application, the EMG signal is usually recorded invasively by means of electrodes on a nasogastric tube which is placed inside the esophagus in order to minimize noise and crosstalk from other muscles. Replacing these invasive measurements with an EMG signal obtained non-invasively on the body surface is difficult and requires techniques for signal separation in order to reconstruct the contributions of the individual respiratory muscles...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
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