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Biomedizinische Technik. Biomedical Engineering

Axel Kulcke, Amadeus Holmer, Philip Wahl, Frank Siemers, Thomas Wild, Georg Daeschlein
Worldwide, chronic wounds are still a major and increasing problem area in medicine with protracted suffering of patients and enormous costs. Beside conventional wound treatment, for instance kinds of oxygen therapy and cold plasma technology have been tested, providing an improvement in the perfusion of wounds and their healing potential, but these methods are unfortunately not sufficiently validated and accepted for clinical practice to date. Using hyperspectral imaging technology in the visible (VIS) and near infrared (NIR) region with high spectral and spatial resolution, perfusion parameters of tissue and wounds can be determined...
March 9, 2018: Biomedizinische Technik. Biomedical Engineering
Markus Bongert, Marius Geller, Werner Pennekamp, Volkmar Nicolas
Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients...
March 3, 2018: Biomedizinische Technik. Biomedical Engineering
Hendrik Kohlhof, Sebastian Köhring, Dieter Christian Wirtz, Hartmut Witte
The number of hip and knee arthroplasty replacement surgeries is increasing steadily. In combination with demographic aging and the number of periprosthetic complications, this development has lead to the phenomenon where the need for revision surgery is rising. The problem is, that, while implantation procedures of hip arthroplasties are more or less standardized, explantation is a non-standardized task for experienced specialists, due to the unpredictability of the adequate loosening method. The surgeon often only gets to decide on which tools and methods may be applied to detach the prosthesis, only after getting access to the operation site...
March 2, 2018: Biomedizinische Technik. Biomedical Engineering
Dirk Grosenick, Heidrun Wabnitz, Rainer Macdonald
Optical imaging of biological tissue in vivo at multiple wavelengths in the near-infrared (NIR) spectral range can be achieved with picosecond time resolution at high sensitivity by time-correlated single photon counting. Measuring and analyzing the distribution of times of flight of photons randomly propagated through the tissue has been applied for diffuse optical imaging and spectroscopy, e.g. of human breast tissue and of the brain. In this article, we review the main features and the potential of NIR multispectral imaging with picosecond time resolution and illustrate them by exemplar applications in these fields...
March 1, 2018: Biomedizinische Technik. Biomedical Engineering
Roberta Galli, Matthias Meinhardt, Edmund Koch, Gabriele Schackert, Gerald Steiner, Matthias Kirsch, Ortrud Uckermann
Label-free multiphoton imaging constitutes a promising technique for clinical diagnosis and therapeutic monitoring. Corpora amylacea (CoA) are starch-like structures often found in the diseased brain, whose origin and role in nervous pathologies are still a matter of debate. Recently, CoA in the diseased human hippocampus were found to be second harmonic generation (SHG) active. Here, we show that CoA formed in other parts of the diseased brain and in brain neoplasms display a similar SHG activity. The SHG pattern of CoA depended on laser polarization, indicating that a radial structure is responsible for their nonlinear activity...
February 28, 2018: Biomedizinische Technik. Biomedical Engineering
Richárd Fiáth, Katharina T Hofer, Vivien Csikós, Domonkos Horváth, Tibor Nánási, Kinga Tóth, Frederick Pothof, Christian Böhler, Maria Asplund, Patrick Ruther, István Ulbert
Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6-12 macro- or microelectrodes), limited spatial resolution (0.5-1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices...
February 26, 2018: Biomedizinische Technik. Biomedical Engineering
Vahid Abdollah, Eric C Parent, Michele C Battié
Disc height has been a focus of research on disc degeneration and low back pain (LBP). However, choosing an appropriate method to quantify disc height remains controversial. The aim of the present study was to determine the reliability and construct validity of disc height quantification methods. Repeated semi-automatic measurements of L4-5 and L5-S1 discs were obtained from 43 T2-weighted mid-sagittal 3T magnetic resonance (MR) images of 22 subjects with LBP (43±13 years), blinded to prior measurements. Heights were calculated with area-based methods (using 60%, 80% and 100% of the disc width), and point-based methods (Hurxthal's, Dabbs' and combining the two)...
February 13, 2018: Biomedizinische Technik. Biomedical Engineering
Jiao Cheng, Jing Jin, Ian Daly, Yu Zhang, Bei Wang, Xingyu Wang, Andrzej Cichocki
Brain-computer interface (BCI) systems can allow their users to communicate with the external world by recognizing intention directly from their brain activity without the assistance of the peripheral motor nervous system. The P300-speller is one of the most widely used visual BCI applications. In previous studies, a flip stimulus (rotating the background area of the character) that was based on apparent motion, suffered from less refractory effects. However, its performance was not improved significantly. In addition, a presentation paradigm that used a "zooming" action (changing the size of the symbol) has been shown to evoke relatively higher P300 amplitudes and obtain a better BCI performance...
February 13, 2018: Biomedizinische Technik. Biomedical Engineering
Christoph Hornberger, Heidrun Wabnitz
Pulse oximetry for arterial oxygenation monitoring and tissue oximetry for monitoring of cerebral oxygenation or muscle oxygenation are based on quantitative in vivo diffuse optical spectroscopy. However, in both cases the information on absolute or relative concentration of human tissue constituents and especially on hemoglobin oxygenation can often not be retrieved by model-based analysis. An in vivo calibration against an accepted reference measurement can be a practical alternative. Pulse oximeters and most of commercial cerebral tissue oximeters rely on empirical calibration based on invasive controlled human desaturation studies...
February 9, 2018: Biomedizinische Technik. Biomedical Engineering
Julius Thiele, Christina Schöllig, Malte Bellmann, Marc Kraft
A crossover design study with a small group of subjects was used to evaluate the performance of three microprocessor-controlled exoprosthetic knee joints (MPKs): C-Leg 4, Plié 3 and Rheo Knee 3. Given that the mechanical designs and control algorithms of the joints determine the user outcome, the influence of these inherent differences on the functional characteristics was investigated in this study. The knee joints were evaluated during level-ground walking at different velocities in a motion analysis laboratory...
February 9, 2018: Biomedizinische Technik. Biomedical Engineering
Anna Lohmann, Ludger Keilig, Friedhelm Heinemann, Christoph Bourauel, Istabrak Hasan
Poor stability of a complete denture is a common problem due to bone atrophy of the edentulous ridge. The aim of the present study was to analyze denture stability after receiving implants and to study the biomechanical properties of denture implants and the bone bed using conventional or mini implants. Five models based on computed tomography (CT) data of edentulous patients were created. The overdentures' connection to the implants was assured by means of ball head abutments and rubber rings. In three models, the denture was supported by two to four conventional implants and in two models, the overdenture was supported by three to five mini implants...
February 8, 2018: Biomedizinische Technik. Biomedical Engineering
Martin Oelschlägel, Tobias Meyer, Gabriele Schackert, Matthias Kirsch, Stephan B Sobottka, Ute Morgenstern
Brain tumor resection is even today one of the most challenging disciplines in neurosurgery. The current state of the art for the identification of tumor tissue during the surgical procedure comprises a wide variety of different tools, each with its own limitations and drawbacks. In this paper, we present a novel approach, the use of optical imaging in connection with direct electrical cortical stimulation (DCS), for identification of impaired tumor tissue and functional intact normal brain tissue under intraoperative conditions...
February 5, 2018: Biomedizinische Technik. Biomedical Engineering
Max Rockstroh, Stefan Franke, Raluca Dees, Angela Merzweiler, Gerd Schneider, Max Dingler, Christian Dietz, Jonas Pfeifer, Franziska Kühn, Malte Schmitz, Alexander Mildner, Armin Janß, Jasmin Dell'Anna Pudlik, Marcus Köny, Björn Andersen, Björn Bergh, Thomas Neumuth
The effective development and dissemination of the open integration for the next generation of operating rooms require a comprehensive testing environment. In this paper, we present the various challenges to be addressed in demonstration applications, and we discuss the implementation approach, the foci of the demonstration sites and the evaluation efforts. Overall, the demonstrator setups have proven the feasibility of the service-oriented medical device architecture (SOMDA) and real-time approaches with a large variety of example applications...
February 3, 2018: Biomedizinische Technik. Biomedical Engineering
Krunoslav Stingl, Tobias Peters, Torsten Strasser, Carina Kelbsch, Paul Richter, Helmut Wilhelm, Barbara Wilhelm
Pupillographic campimetry allows measuring the visual field objectively by analyzing the pupil response to perimetric stimuli. One of the drawbacks of this technique, similar to static perimetry, is the need of reliable fixation of the subject. By using stimulus sizes comparable to static perimetry and applying gaze tracking, we enable a retinotopic visual field examination regardless of fixation problems and with an increased stability and improved spatial resolution. Here, we present the results of applying the method in eight normal sighted subjects as well as in three patients suffering from diseases usually diagnosed by perimetry...
January 24, 2018: Biomedizinische Technik. Biomedical Engineering
Martin Kasparick, Malte Schmitz, Björn Andersen, Max Rockstroh, Stefan Franke, Stefan Schlichting, Frank Golatowski, Dirk Timmermann
Modern surgical departments are characterized by a high degree of automation supporting complex procedures. It recently became apparent that integrated operating rooms can improve the quality of care, simplify clinical workflows, and mitigate equipment-related incidents and human errors. Particularly using computer assistance based on data from integrated surgical devices is a promising opportunity. However, the lack of manufacturer-independent interoperability often prevents the deployment of collaborative assistive systems...
January 18, 2018: Biomedizinische Technik. Biomedical Engineering
Michael Czaplik, Verena Voigt, Hannes Kenngott, Hans Clusmann, Rüdiger Hoffmann, Armin Will
In the past decades, modern medicine has been undergoing a change in the direction of digitalisation and automation. Not only the integration of new digital technologies, but also the interconnection of all components can simplify clinical processes and allow progress and development of new innovations. The integration and interconnection of medical devices with each other and with information technology (IT) systems was addressed within the framework of the Federal Ministry of Education and Research (BMBF)-funded lighthouse project OR...
December 29, 2017: Biomedizinische Technik. Biomedical Engineering
Björn Andersen, Martin Kasparick, Hannes Ulrich, Stefan Franke, Jan Schlamelcher, Max Rockstroh, Josef Ingenerf
The new medical device communication protocol known as IEEE 11073 SDC is well-suited for the integration of (surgical) point-of-care devices, so are the established Health Level Seven (HL7) V2 and Digital Imaging and Communications in Medicine (DICOM) standards for the communication of systems in the clinical IT infrastructure (CITI). An integrated operating room (OR) and other integrated clinical environments, however, need interoperability between both domains to fully unfold their potential for improving the quality of care as well as clinical workflows...
December 22, 2017: Biomedizinische Technik. Biomedical Engineering
Hendrik Schorler, Robert Wendlandt, Christian Jürgens, Arndt-Peter Schulz, Christian Kaddick, Felix Capanni
This paper follows up on a recent systematic review of test methods and parameters for biomechanical testing of bone plates and it is the first study that contains recommendations for standardized mechanical testing of bone plate-screw constructs for osteosynthesis. Following the testing philosophy of ASTM F382 and ISO 9585, we have developed standardized quasi-static and dynamic testing methods for straight linear and anatomically shaped plates, including locked type and conventional systems. The test specification comprises torsion and bending tests along the implant axis and therefore modifies and extends the methods proposed by ASTM F382...
December 18, 2017: Biomedizinische Technik. Biomedical Engineering
Frank Golatowski, Armin Janss, Martin Leucker, Thomas Neumuth
No abstract text is available yet for this article.
February 23, 2018: Biomedizinische Technik. Biomedical Engineering
Urban Burnik, Štefan Dobravec, Marko Meža
Software-based medical devices need to be maintained throughout their entire life cycle. The efficiency of after-sales maintenance can be improved by managing medical systems remotely. This paper presents how to design the remote access function extensions in order to prevent risks imposed by uncontrolled remote access. A thorough analysis of standards and legislation requirements regarding safe operation and risk management of medical devices is presented. Based on the formal requirements, a multi-layer machine design solution is proposed that eliminates remote connectivity risks by strict separation of regular device functionalities from remote management service, deploys encrypted communication links and uses digital signatures to prevent mishandling of software images...
December 9, 2017: Biomedizinische Technik. Biomedical Engineering
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