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Biomedizinische Technik. Biomedical Engineering

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https://www.readbyqxmd.com/read/28182575/response-of-a-physiological-controller-for-ventricular-assist-devices-during-acute-patho-physiological-events-an-in-vitro-study
#1
Anastasios Petrou, Panagiotis Pergantis, Gregor Ochsner, Raffael Amacher, Thomas Krabatsch, Volkmar Falk, Mirko Meboldt, Marianne Schmid Daners
The current paper analyzes the performance of a physiological controller for turbodynamic ventricular assist devices (tVADs) during acute patho-physiological events. The numerical model of the human blood circulation implemented on our hybrid mock circulation was extended in order to simulate the Valsalva maneuver (VM) and premature ventricular contractions (PVCs). The performance of an end-diastolic volume (EDV)-based physiological controller for VADs, named preload responsive speed (PRS) controller was evaluated under VM and PVCs...
February 9, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28182574/rapidnam-generative-manufacturing-approach-of-nasoalveolar-molding-devices-for-presurgical-cleft-lip-and-palate-treatment
#2
Franz Xaver Bauer, Markus Schönberger, Johannes Gattinger, Markus Eblenkamp, Erich Wintermantel, Andrea Rau, Florian Dieter Güll, Klaus-Dietrich Wolff, Denys J Loeffelbein
Nasoalveolar molding (NAM) is an accepted treatment strategy in presurgical cleft therapy. The major drawbacks of the treatment listed in the literature relate to the time of the treatment and the coordination of the required interdisciplinary team of therapists, parents, and patients. To overcome these limitations, we present the automated RapidNAM concept that facilitates the design and manufacturing process of NAM devices, and that allows the virtual modification and subsequent manufacture of the devices in advance, with a growth prediction factor adapted to the patient's natural growth...
February 9, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28157689/differential-mineralization-of-human-dental-pulp-stem-cells-on-diverse-polymers
#3
Christian Apel, Patricia Buttler, Jochen Salber, Anandhan Dhanasingh, Sabine Neuss
In tissue engineering, biomaterials are used as scaffolds for spatial distribution of specific cell types. Biomaterials can potentially influence cell proliferation and extracellular matrix formation, both in positive and negative ways. The aim of the present study was to investigate and compare mineralized matrix production of human dental pulp stem cells (DPSC), cultured on 17 different well-characterized polymers. Osteogenic differentiation of DPSC was induced for 21 days on biomaterials using dexamethasone, L-ascorbic-acid-2-phosphate, and sodium β-glycerophosphate...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28157688/pattern-recognition-of-enrichment-levels-of-selex-based-candidate-aptamers-for-human-c-reactive-protein
#4
Xinliang Yu, Ruqin Yu, Xiaohai Yang
Selecting aptamers for human C-reactive protein (CRP) would be of critical importance in predicting the risk for cardiovascular disease. The enrichment level of DNA aptamers is an important parameter for selecting candidate aptamers for further affinity and specificity determination. This paper is the first report on pattern recognition used for CRP aptamer enrichment levels in the systematic evolution of ligands by exponential enrichment (SELEX) process, by applying structure-activity relationship models. After generating 10 rounds of graphene oxide (GO)-SELEX and 1670 molecular descriptors, eight molecular descriptors were selected and five latent variables were then obtained with principal component analysis (PCA), to develop a support vector classification (SVC) model...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28121615/physiological-closed-loop-control-of-mechanical-ventilation-and-extracorporeal-membrane-oxygenation
#5
Christian Brendle, Thorsten Mülders, Jan Kühn, Thorsten Janisch, Rüdger Kopp, Rolf Rossaint, Andre Stollenwerk, Stefan Kowalewski, Berno Misgeld, Steffen Leonhardt, Marian Walter
A new concept is presented for cooperative automation of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) therapy for treatment of acute respiratory distress syndrome (ARDS). While mechanical ventilation is continuously optimized to promote lung protection, extracorporeal gas transfer rates are simultaneously adjusted to control oxygen supply and carbon dioxide removal using a robust patient-in-the-loop control system. In addition, the cooperative therapy management uses higher-level algorithms to adjust both therapeutic approaches...
January 25, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28121614/benefits-of-object-oriented-models-and-modelichart-modern-tools-and-methods-for-the-interdisciplinary-research-on-smart-biomedical-technology
#6
Jonas Gesenhues, Marc Hein, Maike Ketelhut, Moriz Habigt, Daniel Rüschen, Mare Mechelinck, Thivaharan Albin, Steffen Leonhardt, Thomas Schmitz-Rode, Rolf Rossaint, Rüdiger Autschbach, Dirk Abel
Computational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined...
January 25, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28110313/framework-for-2d-3d-image-fusion-of-infrared-thermography-with-preoperative-mri
#7
Nico Hoffmann, Florian Weidner, Peter Urban, Tobias Meyer, Christian Schnabel, Yordan Radev, Gabriele Schackert, Uwe Petersohn, Edmund Koch, Stefan Gumhold, Gerald Steiner, Matthias Kirsch
Multimodal medical image fusion combines information of one or more images in order to improve the diagnostic value. While previous applications mainly focus on merging images from computed tomography, magnetic resonance imaging (MRI), ultrasonic and single-photon emission computed tomography, we propose a novel approach for the registration and fusion of preoperative 3D MRI with intraoperative 2D infrared thermography. Image-guided neurosurgeries are based on neuronavigation systems, which further allow us track the position and orientation of arbitrary cameras...
January 23, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28099115/examination-of-the-reliability-of-an-inertial-sensor-based-gait-analysis-system
#8
Katja Orlowski, Falko Eckardt, Fabian Herold, Norman Aye, Jürgen Edelmann-Nusser, Kerstin Witte
Gait analysis is an important and useful part of the daily therapeutic routine. InvestiGAIT, an inertial sensor-based system, was developed for using in different research projects with a changing number and position of sensors and because commercial systems do not capture the motion of the upper body. The current study is designed to evaluate the reliability of InvestiGAIT consisting of four off-the-shelf inertial sensors and in-house capturing and analysis software. Besides the determination of standard gait parameters, the motion of the upper body (pelvis and spine) can be investigated...
January 18, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076297/dynamics-of-the-cardiovascular-autonomic-regulation-during-orthostatic-challenge-is-more-relaxed-in-women
#9
Sina Reulecke, Sonia Charleston-Villalobos, Andreas Voss, Ramón González-Camarena, Jesús González-Hermosillo, Mercedes Gaitán-González, Guadalupe Hernández-Pacheco, Rico Schroeder, Tomás Aljama-Corrales
Linear dynamic analysis of cardiovascular and respiratory time series was performed in healthy subjects with respect to gender by shifted short-term segments throughout a head-up tilt (HUT) test. Beat-to-beat intervals (BBI), systolic (SYS) and diastolic (DIA) blood pressure and respiratory interval (RESP) time series were acquired in 14 men and 15 women. In time domain (TD), the descending slope of the auto-correlation function (ACF) (BBI_a31cor) was more pronounced in women than in men (p<0.05) during the HUT test and considerably steeper (p<0...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076296/efficiency-test-of-current-carotid-embolic-protection-devices
#10
Anja Kurzhals, Jörn-Bo Matthies, Reimer Andresen, Christian Wissgott, Klaus-Peter Schmitz, Niels Grabow, Wolfram Schmidt
Embolic protection devices were developed to reduce the risk of stroke during carotid artery stenting. The aim of this study was to test the capture efficiency of five embolic protection devices under reproducible in vitro conditions. The setup consisted of silicone tubes representing the vessel modeling round and oval cross sections. Spherical polystyrene particles (150 μm, COOH-coating) were used to simulate the plaque. The particles were inserted in a clean water circuit and either captured by the device or collected in a glass filter...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076295/convolutive-blind-source-separation-of-surface-emg-measurements-of-the-respiratory-muscles
#11
Eike Petersen, Herbert Buchner, Marcus Eger, Philipp Rostalski
Electromyography (EMG) has long been used for the assessment of muscle function and activity and has recently been applied to the control of medical ventilation. For this application, the EMG signal is usually recorded invasively by means of electrodes on a nasogastric tube which is placed inside the esophagus in order to minimize noise and crosstalk from other muscles. Replacing these invasive measurements with an EMG signal obtained non-invasively on the body surface is difficult and requires techniques for signal separation in order to reconstruct the contributions of the individual respiratory muscles...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076294/simulation-of-effects-of-the-electrode-structure-and-material-in-the-density-measuring-system-of-the-peripheral-nerve-based-on-micro-electrical-impedance-tomography
#12
Saber Behkami, Javad Frounchi, Firouz Ghaderi Pakdel, Thomas Stieglitz
The electrode structure in micro-electrical impedance tomography (MEIT) highly influences the measurement sensitivity and therefore the reconstructed image quality. Hence, optimizing the electrode structure leads to the improvement of image quality in the reconstruction procedure. Although there have been many investigations on electrical impedance tomography (EIT) electrodes, there is no comprehensive study on their influence on images of the peripheral nerve. In this paper, we present a simulation method to study the effects of the electrode structure in the density measurement system of the peripheral nerve based on MEIT...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076293/electromyographic-classification-of-effort-in-muscle-strength-assessment
#13
Karan Veer, Tanu Sharma
Dual-channel evaluation of surface electromyogram (SEMG) signals acquired from amputee subjects using computational techniques for classification of arm motions is presented in this study. SEMG signals were classified by the neural network (NN) and interpretation was done using statistical techniques to extract the effectiveness of the recorded signals. From the results, it was observed that there exists a calculative difference in amplitude gain across different motions and that SEMG signals have great potential to classify arm motions...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076292/445-nm-diode-laser-assisted-debonding-of-self-ligating-ceramic-brackets
#14
Steffen Stein, Alexander Kleye, Michael Schauseil, Andreas Hellak, Heike Korbmacher-Steiner, Andreas Braun
OBJECTIVES: This study determined the influence of irradiation on aesthetic ceramic brackets with a novel 445-nm diode laser prior to debonding on the bracket failure mode. MATERIALS AND METHODS: Thirty ceramic brackets (In-Ovation® C, GAC) were standard-bonded to the oral and buccal planed and polished enamel surfaces of 15 caries-free human 3rd molars. Prior to study-blinded debonding, the brackets in the laser group were irradiated with the diode laser (SIROLaser Blue®, Sirona), while the irradiation was simulated within the conventional group...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076291/individual-construction-of-freeform-fabricated-polycaprolactone-scaffolds-for-osteogenesis
#15
Lu Liu, Guixin Shi, Ying Cui, Hui Li, Zhengchao Li, Qiangcheng Zeng, Yong Guo
The construction of engineered bone mostly focuses on simulating the extracellular matrix (ECM) for proper biological activity. However, the complexity of architecture and the variability of the mechanical properties of natural bones are related to individual differences in age, nutritional state, mechanical loading and disease status. Defect substitutions should be normed with the host natural bone, balancing architectural and mechanical adaption, as well as biological activity. Using a freeform fabrication (FFF) method, we prepared polycaprolactone (PCL) scaffolds with different architectures...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28076290/tailored-interactive-sequences-for-continuous-mr-image-guided-freehand-biopsies-of-different-organs-in-an-open-system-at-1-0-tesla-t-initial-experience
#16
Florian Streitparth, Christian Althoff, Martin Jonczyk, Felix Guettler, Martin Maurer, Hendrik Rathke, Keno Moritz Sponheuer, Bernd Hamm, Ulf K Teichgräber, Maximilian de Bucourt
OBJECTIVES: To assess the feasibility, image quality, and accuracy of freehand biopsies of liver, bone, muscle, vertebral disc, soft tissue, and other lesions using balanced steady-state free precession (SSFP, balanced fast field echo: bFFE), spoiled and nonspoiled gradient echo (FFE), and turbo spin echo (TSE) sequences for interactive continuous navigation in an open magnetic resonance imaging (MRI) system at 1.0 tesla (T). METHODS: Twenty-six MR-guided biopsies (five liver, five bone, four muscle, four vertebral disc, one lung, one kidney, one suprarenal gland, and five soft or other tissue) were performed in 23 patients in a 1...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28002026/validation-and-comparison-of-shank-and-lumbar-worn-imus-for-step-time-estimation
#17
William Johnston, Matthew Patterson, Niamh O'Mahony, Brian Caulfield
Gait assessment is frequently used as an outcome measure to determine changes in an individual's mobility and disease processes. Inertial measurement units (IMUs) are quickly becoming commonplace in gait analysis. The purpose of this study was to determine and compare the validity of shank and lumbar IMU mounting locations in the estimation of temporal gait features. Thirty-seven adults performed 20 walking trials each over a gold standard force platform while wearing shank and lumbar-mounted IMUs. Data from the IMUs were used to estimate step times using previously published algorithms and were compared with those derived from the force platform...
December 21, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28002025/increased-beat-to-beat-t-wave-variability-in-myocardial-infarction-patients
#18
Muhammad A Hasan, Derek Abbott, Mathias Baumert, Sridhar Krishnan
The purpose of this study was to investigate the beat-to-beat variability of T-waves (TWV) and to assess the diagnostic capabilities of T-wave-based features for myocardial infarction (MI). A total of 148 recordings of standard 12-lead electrocardiograms (ECGs) from 79 MI patients (22 females, mean age 63±12 years; 57 males, mean age 57±10 years) and 69 recordings from healthy subjects (HS) (17 females, 42±18 years; 52 males, 40±13 years) were studied. For the quantification of beat-to-beat QT intervals in ECG signal, a template-matching algorithm was applied...
December 21, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27987353/a-seepage-outlet-boundary-condition-in-hemodynamics-modeling
#19
Fan He, Lu Hua, Li-Jian Gao
BACKGROUND: In computational fluid dynamics (CFD) models for hemodynamics applications, boundary conditions remain one of the major issues in obtaining accurate fluid flow predictions. OBJECTIVE: As an important part of the arterial circulation, microcirculation plays important roles in many aspects, such as substance exchange, interstitial fluid generation and inverse flow. It is necessary to consider microcirculation in hemodynamics modeling. This is a methodological paper to test and validate a new type of boundary condition never applied to microcirculation before...
December 17, 2016: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/27987352/design-of-a-right-ventricular-mock-circulation-loop-as-a-test-bench-for-right-ventricular-assist-devices
#20
Indra Mueller, So-Hyun Jansen-Park, Michael Neidlin, Ulrich Steinseifer, Dirk Abel, Rüdiger Autschbach, Rolf Rossaint, Thomas Schmitz-Rode, Simon Johannes Sonntag
Right heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the in vitro test bench, which simulates the hemodynamic behavior of the native circulatory system. To model healthy and diseased arterial-pulmonary hemodynamics in adults (mild and severe PH and RHF), a right heart mock circulation loop (MCL) was developed...
December 17, 2016: Biomedizinische Technik. Biomedical Engineering
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