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Cold Spring Harbor Symposia on Quantitative Biology

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https://www.readbyqxmd.com/read/29848514/dorcas-cummings-lecture
#1
(no author information available yet)
No abstract text is available yet for this article.
May 30, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29802152/a-conversation-with-tim-stearns
#2
(no author information available yet)
No abstract text is available yet for this article.
May 25, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29802151/how-the-genome-folds-divides-lives-and-dies
#3
Whitney L Johnson, Kathleen T Xie, Mijung Kwon, Shiwei Liu, David Pellman
No abstract text is available yet for this article.
May 25, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29743337/oocyte-quality-control-causes-mechanisms-and-consequences
#4
Neil Hunter
Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division...
May 9, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29743336/a-conversation-with-martin-hetzer
#5
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29743335/a-conversation-with-maria-jasin
#6
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29728444/emerging-evidence-of-chromosome-folding-by-loop-extrusion
#7
Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Anton Goloborodko, Leonid A Mirny
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating interactions between specific genomic elements? The mechanism of active loop extrusion holds great promise for explaining interphase and mitotic chromosome folding, yet remains difficult to assay directly. We discuss predictions from our polymer models of loop extrusion with barrier elements and review recent experimental studies that provide strong support for loop extrusion, focusing on perturbations to CTCF and cohesin assayed via Hi-C in interphase...
May 4, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29728443/a-conversation-with-leonid-mirny
#8
(no author information available yet)
No abstract text is available yet for this article.
May 4, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29728442/a-conversation-with-timothy-mitchison
#9
(no author information available yet)
No abstract text is available yet for this article.
May 4, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29700236/a-conversation-with-aaron-straight
#10
(no author information available yet)
No abstract text is available yet for this article.
April 26, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29700235/a-conversation-with-yukiko-yamashita
#11
(no author information available yet)
No abstract text is available yet for this article.
April 26, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29700234/a-conversation-with-arshad-desai
#12
(no author information available yet)
No abstract text is available yet for this article.
April 26, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29700233/aurora-a-kinase-function-at-kinetochores
#13
Jennifer G DeLuca
One of the most important regulatory aspects of chromosome segregation is the ability of kinetochores to precisely control their attachment strength to spindle microtubules. Central to this regulation is Aurora B, a mitotic kinase that phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the kinetochore protein Ndc80/Hec1, which is a component of the NDC80 complex, the primary force-transducing link between kinetochores and microtubules. Although Aurora B is regarded as the "master regulator" of kinetochore-microtubule attachment, it is becoming clear that this kinase is not solely responsible for phosphorylating Hec1 and other kinetochore substrates to facilitate microtubule turnover...
April 26, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29686034/topologically-associating-domains-in-chromosome-architecture-and-gene-regulatory-landscapes-during-development-disease-and-evolution
#14
Rafael Galupa, Edith Heard
The packaging of genetic material into chromatin and chromosomes has been recognized for more than a century, thanks to microscopy and biochemical approaches. This was followed by the progressive realization that chromatin organization is critical for genome functions such as transcription and DNA replication and repair. The recent discovery that chromosomes are partitioned at the submegabase scale into topologically associating domains (TADs) has implications for our understanding of gene regulation during developmental processes such as X-chromosome inactivation, as well as for evolution and for the search for disease-associated loci...
April 23, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29686033/homologous-recombination-and-replication-fork-protection-brca2-and-more
#15
Weiran Feng, Maria Jasin
BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks...
April 23, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29686032/noncanonical-biogenesis-of-centrioles-and-basal-bodies
#16
Catarina Nabais, Sónia Gomes Pereira, Mónica Bettencourt-Dias
Centrioles and basal bodies (CBBs) organize centrosomes and cilia within eukaryotic cells. These organelles are composed of microtubules and hundreds of proteins performing multiple functions such as signaling, cytoskeleton remodeling, and cell motility. The CBB is present in all branches of the eukaryotic tree of life and, despite its ultrastructural and protein conservation, there is diversity in its function, occurrence (i.e., presence/absence), and modes of biogenesis across species. In this review, we provide an overview of the multiple pathways through which CBBs are formed in nature, with a special focus on the less studied, noncanonical ways...
April 23, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29610245/function-of-junk-pericentromeric-satellite-dna-in-chromosome-maintenance
#17
Madhav Jagannathan, Yukiko M Yamashita
Satellite DNAs are simple tandem repeats that exist at centromeric and pericentromeric regions on eukaryotic chromosomes. Unlike the centromeric satellite DNA that comprises the vast majority of natural centromeres, function(s) for the much more abundant pericentromeric satellite repeats are poorly understood. In fact, the lack of coding potential allied with rapid divergence of repeat sequences across eukaryotes has led to their dismissal as "junk DNA" or "selfish parasites." Although implicated in various biological processes, a conserved function for pericentromeric satellite DNA remains unidentified...
April 2, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29610244/a-conversation-with-bernard-de-massy
#18
(no author information available yet)
No abstract text is available yet for this article.
April 2, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29610243/impact-of-centrosome-aberrations-on-chromosome-segregation-and-tissue-architecture-in-cancer
#19
Erich A Nigg, Dominik Schnerch, Olivier Ganier
Centrosomes determine the disposition of microtubule networks and thereby contribute to regulate cell shape, polarity, and motility, as well as chromosome segregation during cell division. Additionally, centrioles, the core components of centrosomes, are required for the formation of cilia and flagella. Mutations in genes coding for centrosomal and centriolar proteins are responsible for several human diseases, foremost ciliopathies and developmental disorders resulting in small brains (primary microcephaly) or small body size (dwarfism)...
April 2, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29610242/a-conversation-with-ian-hickson
#20
(no author information available yet)
No abstract text is available yet for this article.
April 2, 2018: Cold Spring Harbor Symposia on Quantitative Biology
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