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Cold Spring Harbor Symposia on Quantitative Biology

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https://www.readbyqxmd.com/read/27815544/functional-genomic-characterization-of-cancer-genomes
#1
Thomas P Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L Hong, Mik Rinne, Andrew J Aguirre, Jesse S Boehm, William C Hahn
International efforts to sequence cancer genomes now provide an overview of the major genetic alterations that occur in most human cancers. These studies have identified many highly recurrent alterations in specific cancer subtypes but have also identified mutations that occur at lower frequency and unstudied variants of known cancer-associated genes. To elucidate the function of such cancer alleles, we have developed several approaches to systematically interrogate genomic changes found in human tumors. In general, we have taken two complementary approaches...
November 4, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27815543/genetic-dissection-of-cancer-development-therapy-response-and-resistance-in-mouse-models-of-breast-cancer
#2
Stefano Annunziato, Marco Barazas, Sven Rottenberg, Jos Jonkers
The cancer genomics revolution has rapidly expanded the inventory of somatic mutations characterizing human malignancies, highlighting a previously underappreciated extent of molecular variability between and within patients. Also in breast cancer, the most commonly diagnosed malignancy in women, this heterogeneity complicates the understanding of the stepwise sequence of pathogenic events and the design of effective and long-lasting target therapies. To disentangle this complexity and pinpoint which molecular perturbations are crucial to hijack the cellular machinery and lead to tumorigenesis and drug resistance, functional studies are needed in model systems that faithfully and comprehensively recapitulate all the salient aspects of their cognate human counterparts...
November 4, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27815542/cell-of-origin-and-cancer-stem-cells-in-tumor-suppressor-mouse-models-of-glioblastoma
#3
Sheila R Alcantara Llaguno, Xuanhua Xie, Luis F Parada
The cellular origins and the mechanisms of progression, maintenance of tumorigenicity, and therapeutic resistance are central questions in the glioblastoma multiforme (GBM) field. Using tumor suppressor mouse models, our group recently reported two independent populations of adult GBM-initiating central nervous system progenitors. We found different functional and molecular subtypes depending on the tumor-initiating cell lineage, indicating that the cell of origin is a driver of GBM subtype diversity. Using an in vivo model, we also showed that GBM cancer stem cells (CSCs) or glioma stem cells (GSCs) contribute to resistance to chemotherapeutic agents and that genetic ablation of GSCs leads to a delay in tumor progression...
November 4, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27811212/to-prime-or-not-to-prime-that-is-the-question
#4
Danielle S Potter, Anthony Letai
Mitochondrial priming is regulated by the B-cell lymphoma 2 (BCL-2) family of proteins and determines a cell's "readiness" for apoptosis. A highly primed cell will undergo apoptosis more easily than an unprimed cell in response to apoptotic stimuli via the intrinsic apoptotic pathway. Priming can be measured via BH3 profiling, which uses BH3 peptides derived from the BH3 domain of pro-apoptotic BH3-only BCL-2 family members to provoke a response from viable mitochondria. BH3 profiling can be performed on tumor cells and can identify mechanisms a cell uses to evade apoptosis and anti-apoptotic dependency to the anti-apoptotic BCL-2 family members...
November 3, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27125265/publisher-s-comment
#5
(no author information available yet)
No abstract text is available yet for this article.
April 28, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/25948641/corrigendum-animal-to-animal-variability-in-neuromodulation-and-circuit-function
#6
Albert W Hamood, Eve Marder
No abstract text is available yet for this article.
May 6, 2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325736/front-matter
#7
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325735/subject-index
#8
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325734/author-index
#9
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325733/a-conversation-with-rick-young
#10
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325732/a-conversation-with-joanna-wysocka
#11
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325731/a-conversation-with-alexander-tarakhovsky
#12
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325730/a-conversation-with-davor-solter
#13
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325729/a-conversation-with-ueli-schibler
#14
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325728/a-conversation-with-bing-ren
#15
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325727/a-conversation-with-wolf-reik
#16
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325726/a-conversation-with-david-page
#17
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325725/a-conversation-with-richard-morimoto
#18
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325724/a-conversation-with-dan-littman
#19
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2015: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27325723/a-conversation-with-susan-lindquist
#20
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2015: Cold Spring Harbor Symposia on Quantitative Biology
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