journal
MENU ▼
Read by QxMD icon Read
search

European Journal of Pharmacology

journal
https://www.readbyqxmd.com/read/29042208/antiallodynic-activity-of-leflunomide-is-partially-inhibited-by-naltrexone-and-glibenclamide-and-associated-with-reduced-production-of-tnf-%C3%AE-and-cxcl-1
#1
Ana Mercy S Brito, Adriana M Godin, Paulo Sérgio A Augusto, Raquel R Menezes, Ivo S F Melo, Marcela G M B Dutra, Sarah O A M Costa, Franciele A Goulart, Felipe F Rodrigues, Isis MoraisMarcela Ísis Morais, Renes R Machado, Márcio M Coelho
Leflunomide, an immunosuppressive drug approved for the treatment of patients with rheumatoid arthritis, exhibits many mechanisms which may affect the nociceptive processing. Therefore, the present study aimed to evaluate the effect induced by leflunomide on the mechanical allodynia in models of inflammatory and neuropathic pain in mice and investigate mechanisms mediating such effects. Per os (p.o.) administration of leflunomide (25, 50 or 100 mg/kg) inhibited the inflammatory edema and mechanical allodynia induced by intraplantar carrageenan...
October 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29042207/nimodipine-attenuates-tau-phosphorylation-at-ser396-via-mir-132-gsk-3%C3%AE-pathway-in-chronic-cerebral-hypoperfusion-rats
#2
Zihu Tan, Yan Chen, Wenting Xie, Xi Liu, Yuanyue Zhu, Yan Zhu
Chronic cerebral hypofusion (CCH) promotes hyperphosphorylation of tau proteins, a key neuropathological trait that reflects neurodegenerative disorders. Nimodipine, an L-type calcium channel antagonist, has been reported to show neuroprotective effects. In this study, we investigated the potential mechanism of nimodipine in tauopathies induced by CCH. MiR-132 is downregulated in tauopathies such as AD and directly targets tau mRNA to regulate its expression. Here, we report that CCH induced miR-132 deficiency and increased tau phosphorylation at Ser396 while tau expression was not influenced...
October 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29042206/alpha-asarone-attenuates-depression-like-behavior-in-nicotine-withdrawn-mice-evidence-for-the-modulation-of-hippocampal-pcreb-levels-during-nicotine-withdrawal
#3
Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohamed
In the present study, the effect α-asarone on nicotine withdrawal-induced depression-like behavior in mice was investigated. In this study, mice were exposed to drinking water or nicotine solution (10-200µg/ml) as a source of drinking for forty days. During this period, daily fluid consumption, food intake and body weight were recorded. The serum cotinine level was estimated before nicotine withdrawal. Naïve mice or nicotine-withdrawn mice were treated with α-asarone (5, 10 and 20mg/kg, i.p.) or bupropion (10mg/kg, i...
October 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29037767/dt-13-synergistically-potentiates-the-sensitivity-of-gastric-cancer-cells-to-topotecan-via-cell-cycle-arrest-in-vitro-and-in-vivo
#4
Hongzhi Du, Yang Liu, Xudong Chen, Xiaowen Yu, Xiaoying Hou, Hongyang Li, Meixiao Zhan, Sensen Lin, Ligong Lu, Shengtao Yuan, Li Sun
Natural medicine has multi-levels, multi-paths and multi-targets, and an increasing number of reports have confirmed that the combination of natural medicine with chemotherapy drugs exhibit a significant synergistic effect. It is necessary to find drug combination strategies to enhance efficacy and reduce toxicity, which can relieve the restrictions on the use of several chemotherapy drugs that have serious toxicity. Our previous reports showed that DT-13 inhibits cancer proliferation, invasion, migration, metastasis, and angiogenesis and induces autophagy...
October 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29032106/effect-of-monoamine-oxidase-inhibitors-on-ischaemia-reperfusion-induced-acute-kidney-injury-in-rats
#5
Hidenobu Tsutsui, Takaomi Shimokawa, Takeshi Miura, Masashi Takama, Toru Nishinaka, Tomoyuki Terada, Masayo Yamagata, Tokihito Yukimura
Increases in renal sympathetic nerve activity during ischaemia and renal venous norepinephrine levels after reperfusion play important roles in the development of ischaemia/reperfusion-induced acute kidney injury. In the present study, we examined the effect of isatin, an endogenous monoamine oxidase inhibitor, on renal venous norepinephrine levels, superoxide production after reperfusion, and ischaemia/reperfusion-induced acute kidney injury. Ischaemia/reperfusion-induced acute kidney injury was accomplished by clamping the left renal artery and vein for 45min, followed by reperfusion, 2 weeks after contralateral nephrectomy...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29032105/a-comprehensive-review-on-the-anti-cancer-properties-and-mechanisms-of-action-of-sesamin-a-lignan-in-sesame-seeds-sesamum-indicum
#6
REVIEW
Amin F Majdalawieh, Mariam Massri, Gheyath K Nasrallah
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its anti-proliferative, pro-apoptotic, anti-inflammatory, anti-metastatic, anti- and pro-angiogenic, and pro-autophagocytic activities. In this review, we provide a comprehensive summary of the reported anti-cancer effects of sesamin, both in vitro and in vivo. Experimental findings related to the potential of sesamin to attenuate oxidative stress, inflammation, proliferation, metastasis, and angiogenesis in various cancer cells and tumors are analyzed...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29032104/participation-of-gabab-receptors-in-cortical-postictal-excitability-in-immature-rats
#7
Pavel Mareš
Arrest of seizures is due to an active inhibition and is followed in mature brain by period of refractoriness markedly present one min after the end of seizures. To study changes in cortical excitability after epileptic seizures we used electrical stimulation of sensorimotor cortical area in immature rats - 25-day-old ones with mature postictal refractoriness and 12-day-old where postictal potentiation of afterdischarges (ADs) is present instead of refractoriness at one minute after the end of the conditioning AD...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29032103/mast-cells-in-atherosclerotic-cardiovascular-disease-activators-and-actions
#8
Petri T Kovanen, Ilze Bot
Mast cells are potent actors involved in inflammatory reactions in various tissues, including both in the intimal and the adventitial layers of atherosclerotic arteries. In the arterial intima, the site of atherogenesis, mast cells are activated to degranulate, and thereby triggered to release an abundance of preformed inflammatory mediators, notably histamine, heparin, neutral proteases and cytokines stored in their cytoplasmic secretory granules. Depending on the stimulus, mast cell activation may also launch prolonged synthesis and secretion of single bioactive molecules, such as cytokines and derivatives of arachidonic acid...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031903/agmatine-inhibits-chronic-morphine-exposure-induced-impairment-of-hippocampal-neural-progenitor-proliferation-in-adult-rats
#9
Ying Liu, Guan-Yi Lu, Wen-Qiang Chen, Yun-Feng Li, Ning Wu, Jin Li
Our previous studies have shown that agmatine inhibited opioid dependence, yet the neural mechanism remains unclear. Growing evidence showed that opioids decrease neurogenesis in the adult hippocampal subgranular zone by inhibiting neural progenitor proliferation. However, whether agmatine affects chronic opioid exposure-induced impairment to hippocampal neural progenitor cell proliferation remains unknown. In the present study, we investigated the role of agmatine in hippocampal neural progenitors in morphine dependence rats...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031902/chrysophanol-inhibits-endoplasmic-reticulum-stress-in-cerebral-ischemia-and-reperfusion-mice
#10
Yongmei Zhao, Yalan Fang, Haiping Zhao, Jincheng Li, Yunxia Duan, Wenjuan Shi, Yuyou Huang, Li Gao, Yumin Luo
Endoplasmic reticulum (ER) stress plays a critical role in mediating ischemia/reperfusion (I/R) damage in the brain. Our previous study showed that Chrysophanol (CHR) alleviated cerebral ischemic injury in mice and nuclear factor-κB (NF-κB) involved in its neuroprotective effect, but the precise mechanism remains not fully understood. The present study investigated the effect of CHR treatment on I/R-induced ER stress. Mice were subjected to middle cerebral artery occlusion (MCAO) for 45min and received either vehicle or CHR (0...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031901/als-and-ftd-insights-into-the-disease-mechanisms-and-therapeutic-targets
#11
Rajka M Liscic
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders, related by signs of deteriorating motor and cognitive functions, and short survival. The causes are still largely unknown and no effective treatment currently exists. It has been shown that FTLD may coexist with ALS. The overlap between ALS and frontotemporal dementia (FTD), the clinical syndrome associated with FTLD, occurs at clinical, genetic, and pathological levels. The hallmark proteins of the pathognomonic inclusions are SOD-1, TDP-43 or FUS, rarely the disease is caused by mutations in the respective genes...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031900/resveratrol-improved-detrusor-fibrosis-induced-by-mast-cells-during-progression-of-chronic-prostatitis-in-rats
#12
Yi He, Huizhi Zeng, Yang Yu, Jiashu Zhang, Qi Liu, Bo Yang
To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. Experiments of bladder pressure and volume test in rats are used to investigate the effect of resveratrol on urinary dysfunction in CP rats. To assess tissue fibrosis, picrosirius red staining is performed...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031899/synapse-formation-in-the-brain-can-be-enhanced-by-co-administering-three-specific-nutrients
#13
Richard J Wurtman
The memory impairments of early Alzheimer's disease [AD] are thought to result from a deficiency in synapses within the hippocampus and related brain regions. This deficiency could result from an acceleration in synapse turnover - perhaps caused by an endogenous neurotoxin like A-beta oligomers - or from a decrease in the production of the synaptic membrane needed to form new synapses. An AD-associated decrease in synaptogenesis almost certainly does occur, inasmuch as major decreases are also observed in the numbers of hippocampal dendritic spines, the immediate cytologic precursor of glutamatergic synapses...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031898/comparative-analysis-of-ginsenosides-in-human-glucocorticoid-receptor-binding-transactivation-and-transrepression
#14
Catherine Hu, Aik Jiang Lau, Rui Qi Wang, Thomas K H Chang
Conflicting data exist on the effect of ginsenosides on transactivation of human glucocorticoid receptor α (herein referred to as glucocorticoid receptor), and relatively little is known regarding the effect of these chemicals on transrepression of this receptor. We investigated the effect of 20(S)-protopanaxadiol (PPD), PPD-type ginsenosides (Rb1, Rb2, Rc, Rd, Rh2, and Compound K), 20(S)-protopanaxatriol (PPT), and PPT-type ginsenosides (Re, Rf, Rg1, and Rh1) on glucocorticoid receptor binding, transactivation, and transrepression...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29024691/mechanisms-involved-in-the-increased-sensitivity-of-the-rabbit-basilar-artery-to-atrial-natriuretic-peptide-in-diabetes
#15
Mikahela A López-Morales, José M Centeno, Teresa Jover-Mengual, Vannina G Marrachelli, María C Burguete, María Castelló-Ruiz, Alicia Aliena-Valero, Enrique Alborch, Germán Torregrosa, Juan B Salom, Francisco J Miranda
Atrial natriuretic peptide (ANP) is a vasodilator with significant regional differences and controversial effects in the cerebral circulation, a vascular bed particularly prone to diabetes-induced complications. The present study has investigated how alloxan-induced diabetes modifies the mechanisms involved in the response of the rabbit basilar artery to ANP. ANP (10(-12)-10(-7)M) relaxed precontracted basilar arteries, with higher potency in diabetic than in control rabbits. In arteries from both groups of animals, endothelium removal reduced ANP-induced relaxations...
October 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29017758/in-vitro-and-in-vivo-pharmacological-characterization-of-asp8477-a-novel-highly-selective-fatty-acid-amide-hydrolase-inhibitor
#16
Tomonari Watabiki, Noriko Tsuji, Tetsuo Kiso, Tohru Ozawa, Fumie Narazaki, Shuichiro Kakimoto
Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide (AEA), an endogenous CB. Recently, we discovered a novel FAAH inhibitor, 3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477). In vitro studies demonstrated that ASP8477 inhibited human FAAH-1, FAAH-1 (P129T) and FAAH-2 activity with IC50 values of 3...
October 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28993159/prevention-of-cholesterol-gallstone-disease-by-schaftoside-in-lithogenic-diet-induced-c57bl-6-mouse-model
#17
Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou, Suiqing Mi
Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. Whether SS inhibits cholesterol (Ch) gallstone formation has not been investigated. This study examined the effects of oral intake of SS on Ch gallstone formation in C57BL/6 mice fed a lithogenic diet. The rate of gallstone formation was recorded. Levels of Ch, triglycerides (TG) and bile salts (BS) were measured in the bile and serum...
October 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28993160/inhibition-of-morphine-tolerance-by-mrgc-receptor-via-modulation-of-interleukin-1%C3%AE-and-matrix-metalloproteinase-9-in-dorsal-root-ganglia-in-rats
#18
Yue Zhang, Kai Wang, Minyan Lin, Qi Li, Yanguo Hong
Opiate tolerance is a critical issue in pain management. Previous studies show that activation of Mas-related gene (Mrg) C receptor can modulate the development of morphine tolerance. This study was designed to investigate the underlying mechanism(s). Intrathecal (i.t.) administration of morphine (20µg) increased the expression of interleukin-1β (IL-1β) and matrix metalloproteinase-9 (MMP-9) in small- and medium-sized neurons in dorsal root ganglia (DRG). Co-administration of bovine adrenal medulla 8-22 (BAM8-22), a selective MrgC receptor agonist, via i...
October 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28993158/high-potency-block-of-kir4-1-channels-by-pentamidine-molecular-basis
#19
Iván A Aréchiga-Figueroa, Leticia G Marmolejo-Murillo, Meng Cui, Mayra Delgado-Ramírez, Marcel A G van der Heyden, José A Sánchez-Chapula, Aldo A Rodríguez-Menchaca
Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and contribute to a wide range of physiological processes. Kir4.1 channel expression is found in the brain, inner ear, eye, and kidney. Loss-of-function mutations in the pore-forming Kir4.1 subunit cause an autosomal recessive disorder characterized by epilepsy, ataxia, sensorineural deafness and tubulopathy (SeSAME/EST syndrome). Despite its importance in physiological and pathological conditions, pharmacological research of Kir4...
October 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28989085/ferulic-acid-relaxed-rat-aortic-small-mesenteric-and-coronary-arteries-by-blocking-voltage-gated-calcium-channel-and-calcium-desensitization-via-dephosphorylation-of-erk1-2-and-mypt1
#20
Zhong-Yan Zhou, Jia-Qi Xu, Wai-Rong Zhao, Xin-Lin Chen, Yu Jin, Nuo Tang, Jing-Yi Tang
Ferulic acid, a natural ingredient presents in several Chinese Materia Medica such as Radix Angelicae Sinensis, has been identified as an important multifunctional and physiologically active small molecule. However, its pharmacological activity in different blood vessel types and underlying mechanisms are unclear. The present study was to investigate the vascular reactivity and the possible action mechanism of FA on aorta, small mesenteric arteries and coronary arteries isolated from Wistar rats. We found FA dose-dependently relieved the contraction of aorta, small mesenteric arteries and coronary arteries induced by different contractors, U46619, phenylephrine (Phe) and KCl...
October 6, 2017: European Journal of Pharmacology
journal
journal
25226
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"