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Acta Neurobiologiae Experimentalis

Daria Nowak, Lies De Groef, Lieve Moons, Jerzy W Mozrzymas
Over the past two decades, metalloproteinases (MMPs), including MMP‑2, MMP‑3, and MMP‑9, have been implicated as important players in mechanisms underlying various forms of neuroplasticity. In particular, MMP‑3 was found to be involved in both cognitive functions and in plasticity phenomena, but the underlying molecular mechanisms remain largely elusive. In general, it is believed that functional plasticity of neurons is associated with morphological alterations. Interestingly, MMP‑9, in addition to playing a key role in synaptic plasticity, was found to affect plasticity‑related spine morphology changes...
2018: Acta Neurobiologiae Experimentalis
Vladas Valiulis, Giedrius Gerulskis, Kastytis Dapšys, Karolina Valavičiūtė, Aldona Šiurkutė, Valentinas Mačiulis
Repetitive transcranial magnetic stimulation (rTMS) is a popular and effective treatment for drug resistant depression. However, there is considerable variability in clinical outcomes, in previous studies and between patients. Because of high requirements for the use of fMRI based neuronavigation, many practitioners of rTMS still choose to use a standard 5 cm rule for rTMS coil placement which leads to large variations in which brain regions are being stimulated. We decided to test the possibilities of a MNI based MR‑less neuronavigation system in rTMS depression treatment, by comparing the physiological effects and clinical outcomes of 3 distinct stimulation targets...
2018: Acta Neurobiologiae Experimentalis
Zuzana Dzirbikova, Alzbeta Talarovičová, Peter Štefánik, Lucia Olexová, Lucia Kršková
Steroid hormones are important mediators of prenatal maternal effects and play an important role in fetal programming. The aim of our study was to investigate how testosterone enhancement during pregnancy influences neurobehavioral aspects of social coping of rat offspring in adulthood. Pregnant rat dams were exposed to depot form of testosterone during the last third of pregnancy (i.e., beginning on the 14th day of pregnancy). Their adult offspring were later tested in a social interaction test and expression of oxytocin and arginine-vasopressin mRNA in the hypothalamic nuclei was evaluated...
2018: Acta Neurobiologiae Experimentalis
Safiye Cavdar, Merve Özgür, Yusuf Özgür Çakmak, Yasemin Kuvvet, Sıla Kezban Kunt, Gökay Sağlam
The subthalamic nucleus (STN) is important for normal movement as well as in movement disorders. The STN is a target nuclei in patients with advanced Parkinson's disease (PD). Deep brain stimulation (DBS) is a standard surgical treatment for PD. Although DBS results in a significant reduction in motor disability, several negative side effects have been reported. Thus, to understand the side effects of DBS the connection of the STN should be well known. Therefore, the present study aims to re‑examine the STN with an emphasis on poorly‑ or un‑documented connections...
2018: Acta Neurobiologiae Experimentalis
Andrés Molero-Chamizo
The role of the amygdala in the acquisition of conditioned taste aversion (CTA) is unclear. The lesion studies that have explored specific nuclei of the amygdala point to a probable involvement of the basolateral amygdala, but it remains unclear whether the function of the amygdala in CTA is limited to the activity of the basolateral amygdala. In the current study, extensive bilateral lesions of the amygdala were performed in Wistar rats to explore if the destruction of the amygdala affects the acquisition of CTA, as has been reported with selective lesions of the basolateral amygdala...
2018: Acta Neurobiologiae Experimentalis
Bartosz Doktór, Milena Damulewicz, Wojciech Krzeptowski, Barbara Bednarczyk, Elżbieta Małgorzata Pyza
Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson's disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of Bruchpilot (BRP), a presynaptic scaffolding protein that is crucial for neurotransmission in all type of synapses in Drosophila...
2018: Acta Neurobiologiae Experimentalis
Wei Huang, Chen Chen, Xufeng Liu
Recent physiological studies indicate that weightlessness reliably alters ocular structure and function, as well as the ability to process visual‑spatial information. The posterior parietal cortex (PPC) and lateral geniculate nucleus (LGN) are two key brain areas implicated in the processing of visual‑spatial information. Here, we used the modified tail‑suspension rat model to simulate the physiological effects of microgravity. Rats were divided into four groups, which exposed to the simulated microgravity environment for 0 (Control group), 7, 14, or 28 days...
2018: Acta Neurobiologiae Experimentalis
Katarzyna Stachowicz
Synaptic plasticity simply put, is the activity‑dependent modification of the strength or efficacy of synaptic transmission in the network of synapses in the brain. The role of synaptic plasticity in disease is an active area of research. Changes in plasticity translate to the release of neurotransmitters at the synapse and subsequently, the way humans see the world. It is known that neuropsychiatric disorders such as depression, posttraumatic stress disorder (PTSD), and Alzheimer's disease (AD) are related to pathological changes in dynamic processes in synapses, dialogue between neurons, and finally, changes in overall plasticity...
2018: Acta Neurobiologiae Experimentalis
Artur Jan Kiepura, Andrzej Kochański
Charcot‑Marie‑Tooth type 1A (CMT1A) is a dysmyelinating disease of the peripheral nervous system that results in a slow progressive weakening and wasting of the distal muscles of the upper and lower limbs. Despite extensive research and clinical trials there is still no treatment for CMT1A that results in complete neurological improvement. Recent studies investigating various pharmacological modulators of adenylyl cyclase activity, including ascorbic acid and ligands of G protein‑coupled receptors (GPCRs), provide hope for future treatments of this type of hereditary motor and sensory neuropathy...
2018: Acta Neurobiologiae Experimentalis
Makbule Gezmen-Karadağ, Elif Çelik, Fatma Zehra Kadayifçi, Özge Yeşildemir, Yasemin Ertaş Öztürk, Duygu Ağagündüz
Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food‑drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food‑drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews, reports, and original articles on general or specific drug interactions with food, in patients with a variety of neurological and psychological diseases...
2018: Acta Neurobiologiae Experimentalis
Pilani Nkomozepi, Pedzisai Mazengenya, Amadi O Ihunwo
Most avian neurogenesis studies have previously focused on the song control system and little attention has been given to non‑song birds. The objective of this study was to assess changes in neurogenesis associated with post‑hatching age (3‑12 weeks) in the Japanese quail brain using proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry. PCNA‑immunoreactive (ir) cells were observed mainly in the olfactory bulb ventricular zone, telencephalic ventricular zones and cerebellum...
2018: Acta Neurobiologiae Experimentalis
Miroslaw Wyczesany, Tomasz S Ligeza, Agnieszka Tymorek, Agnieszka Adamczyk
In the study we investigated how current mood affects spontaneous perceptual processes of neutral stimuli of low‑arousal, unrelated to any specific task. Two separate but similar procedures were carried out: one using functional magnetic resonance imaging (fMRI), the other using electroencephalography based source localization. In both experiments, sessions of passive viewing of neutral pictures were preceded by either a negative or positive mood induction. In response to neutral stimuli, we observed higher activation of visual areas after positive mood induction and lower activations in medial prefrontal and right frontotemporal regions after negative mood induction...
2018: Acta Neurobiologiae Experimentalis
Algis Bertulis, Tadas Surkys, Arūnas Bielevičius
In the present visual psychophysical study, the Oppel‑Kundt and and Müller‑Lyer illusion magnitudes were measured separately (by single figures) and in combination (by two patterns superposed spatially). Data for 30 subjects revealed extensive variability both for the separate and combined illusion strength. Nevertheless, the effect of addition of the perceived length distortions was established. The combined illusions were significantly stronger than the separate ones. Dynamics of the misperceptions summation was studied by varying length of the Müller‑Lyer wings in the superposed stimuli...
2018: Acta Neurobiologiae Experimentalis
Libor Cerny, Jan Vokral, Olga Dlouha
Problems with hearing aids, particularly with regard to speech intelligibility in the presence of noise, are commonly reported by older individuals in everyday practice. The main goal of this study was to measure differences in speech intelligibility between older and younger people and to establish how speech intelligibility in competitive noise differs between younger and older populations with similar hearing status. More than 400 persons were tested using the Czech Test of Sentence Intelligibility in Babble Noise and divided into younger (40-65 years) and older (66-85 years) age groups...
2018: Acta Neurobiologiae Experimentalis
Yulia V Dobryakova, Olga Y Ivanova, Vladimir A Markevich
Muscarinic acetylcholine receptors (mAChR) are known to be related to learning and memory processes. Inactivation of mAChR by cholinergic antagonists have been shown to produce amnesia in a variety of behavioral tasks. In this study, we investigated the role of M1 and M2 AChR on passive avoidance learning and plasticity of synapses formed by Schaffer collaterals in freely moving rats. Experiments were performed using Wistar male rats. Seven days before testing, a recording electrode was lowered in the CA1 region under chloral hydrate anaesthesia to record the field excitatory postsynaptic potential (fEPSP) in response to Schaffer collateral stimulation...
2018: Acta Neurobiologiae Experimentalis
Hanna B Cygan, Hanna Okuniewska, Katarzyna Jednoróg, Artur Marchewka, Marek Wypych, Anna Nowicka
The ability to "read" the information about facial identity, expressed emotions, and intentions is crucial for non‑verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Both disorders have a significant impact on face perception and recognition, thus creating a unique neurodevelopmental condition...
2018: Acta Neurobiologiae Experimentalis
Mateusz Rusiniak, Andrzej Wróbel, Katarzyna Cieśla, Agnieszka Pluta, Monika Lewandowska, Joanna Wójcik, Piotr Henryk Skarżyński, Tomasz Wolak
Alpha rhythm, described by Hans Berger, is mainly recorded from the occipital cortex (OCC) of relaxed subjects with their eyes closed.Early studies indicated the thalamo‑cortical circuit as the origin of alpha rhythm. Recent works suggest an additional relationship between alpha rhythm and the Default Mode Network (DMN). We simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) signals in 36 young males asked to alternately close and open their eyes in 30‑s blocks...
2018: Acta Neurobiologiae Experimentalis
Inna V Vereshchaka, Andriy V Maznychenko, Olena P Mankivska, Volodymyr O Maisky, Oleh V Vlasenko, Olexandr V Dovgan', Olga L Ocheretna, Tomasz Tomiak, Alexander I Kostyukov
We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7‑nitroindazole (7‑NI) or L‑arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c‑Fos immunoreactivity in the spinal neurons in three groups of rats (tendon‑vibrated, tendon‑vibrated + 7‑NI and tendon‑vibrated + LA)...
2018: Acta Neurobiologiae Experimentalis
Marta Grochowska, Marcin Wojnar, Marek Radkowski
The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. The correlation between gut dysbiosis and development of psychiatric, autoimmune and allergic diseases as well as bidirectional communication between brain and gut microflora have been shown...
2018: Acta Neurobiologiae Experimentalis
Shahram Oliaei, Mohammed N Ashtiani, Kamran Azma, Sandra Saidi, Mahmood-Reza Azghani
Standing on an unstable platform requires continuous effort of the neuro‑musculoskeletal system. The aim of the present study is to evaluate the ability to remain standing on an unstable platform at different levels of postural and cognitive difficulty. Healthy young males stood in the sagittal plane on an unstable platform supported by a pair of springs with modifiable stiffness. The balance test also assessed different levels of vision and cognitive function. Linear and nonlinear metrics of standing, based on motion captured kinematic data, were assessed to analyze the stability of standing...
2018: Acta Neurobiologiae Experimentalis
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