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Acta Neurobiologiae Experimentalis

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https://www.readbyqxmd.com/read/28094823/anhedonia-but-not-passive-floating-is-an-indicator-of-depressive-like-behavior-in-two-chronic-stress-paradigms
#1
Mikhail Yu Stepanichev, Anna O Tishkina, Margarita R Novikova, Irina P Levshina, Sofiya V Freiman, Mikhail V Onufriev, Olga A Levchenko, Natalia A Lazareva, Natalia V Gulyaeva
Depression is the most common form of mental disability in the world. Depressive episodes may be precipitated by severe acute stressful events or by mild chronic stressors. Studies on the mechanisms of depression require both appropriate experimental models (most of them based on the exposure of animals to chronic stressors), and appropriate tests for assessment of depressive states. In this study male Wistar rats were exposed to two different chronic stress paradigms: an eight-week chronic unpredictable mild stress or a two-week combined chronic stress...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094822/analysis-of-methionine-synthase-rs1805087-gene-polymorphism-in-autism-patients-in-northern-iran
#2
Rosa Haghiri, Farhad Mashayekhi, Elham Bidabadi, Zivar Salehi
Autism is characterized by impairment in reciprocal communication and speech, repetitive behaviors, and social communication. The genetic and environmental factors play roles in the pathogenesis of autism. It was recently shown that the genes involved in the folate/homocysteine pathway may be risk factors for autistic children. One of the genes that may be the risk factor for autism is Methionine synthase (MTR). MTR is responsible for the regeneration of methionine from homocysteine. The aim of this study was to analyze the association of MTR A2756G gene polymorphism (rs1805087) and the risk of autism in a population in northern Iran...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094821/upregulation-of-ccl3-mip-1alpha-regulated-by-mapks-and-nf-kappab-mediates-microglial-inflammatory-response-in-lps-induced-brain-injury
#3
Xiaobo Zhu, Dee Wei, Ou Chen, Zhaohua Zhang, Jiang Xue, Shanying Huang, Weiwei Zhu, Yibiao Wang
Growing evidence suggests that macrophage inflammatory protein (MIP)-1alpha (synonym CCL3) is upregulated in the neuroinflammatory processes initiated by some brain disorders, but its precise role and regulatory mechanism remain unclear. The present work aims to evaluate the role of CCL3/MIP-1alpha in lipopolysaccharide (LPS)-induced brain injury, and investigate whether the MAPKs and NF-kappaB regulate CCL3/MIP-1alpha expression. We firstly examined the patterns of CCL3/MIP-1alpha expression and phosphorylation of MAPKs in the brains of rats 6, 24, and 72 h after LPS administration...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094820/the-effect-of-network-template-from-normal-subjects-in-the-detection-of-network-impairment
#4
Huang Chun-Chao, Lin Shang-Hua, Lin Ching-Po, The Alzheimer's Disease Neuroimaging Initiative
This study aimed to provide a simple way to approach group differences by independent component analysis when researching functional connectivity changes of resting-state network in brain disorders. We used baseline resting state functional magnetic resonance imaging from the Alzheimer's disease neuroimaging initiative dataset and performed independent component analysis based on different kinds of subject selection, by including two downloaded templates and single-subject independent component analysis method...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094819/age-dependent-concomitant-changes-in-synaptic-dysfunction-and-gabaergic-pathway-in-the-app-ps1-mouse-model
#5
Tutu Oyelami, An De Bondt, Ilse Van den Wyngaert, Kirsten Van Hoorde, Luc Hoskens, Hamdy Shaban, John A Kemp, Wilhelmus H Drinkenburg
Synaptic dysfunction is a well-documented manifestation in animal models of Alzheimer's disease pathology. In this context, numerous studies have documented reduction in the functionality of synapses in various models. In addition, recent research has shed more light on increased excitability and its link to seizures and seizure-like activities in AD patients as well as in mouse models. These reports of hyperexcitability contradict the observed reduction in synaptic function and have been suggested to be as a result of the interplay between inhibitory and excitatory neuronal mechanism...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094818/the-physiology-of-blood-platelets-and-changes-of-their-biological-activities-in-multiple-sclerosis
#6
Barbara Wachowicz, Agnieszka Morel, Elżbieta Miller, Joanna Saluk
Increasing evidence indicates that blood platelets contribute to diverse processes that extend beyond hemostasis. Many of the same mechanisms that play a role in hemostasis and thrombosis facilitate platelets the participation in other physiological and pathological processes, particularly in the inflammation, the immune response and central nervous system disorders. Platelets are involved in pathophysiology of central nervous system diseases, especially in the pathogenesis of multiple sclerosis, but their role appears to be neglected...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28094817/immune-dysfunction-and-neuroinflammation-in-autism-spectrum-disorder
#7
Geir Bjorklund, Khaled Saad, Salvatore Chirumbolo, Janet K Kern, David A Geier, Mark R Geier, Mauricio A Urbina
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder with a complex pathogenesis. Many studies over the last four decades have recognized altered immune responses among individuals diagnosed with ASD. The purpose of this critical and comprehensive review is to examine the hypothesis that immune dysfunction is present more frequently, and it is related to ASD in humans. It was found that that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells, monocytes, natural killer cells, and dendritic cells...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685777/spatial-memory-formation-differentially-affects-c-fos-expression-in-retrosplenial-areas-during-place-avoidance-training-in-rats
#8
Monika Malinowska, Monika Niewiadomska, Malgorzata Wesierska
The retrosplenial cortex is involved in spatial memory function, but the contribution of its individual areas is not well known. To elucidate the involvement of retrosplenial cortical areas 29c and 30 in spatial memory, we analyzed the expression of c-Fos in these areas in the experimental group of rats that were trained in a spatial place avoidance task, i.e. to avoid shocks presented in an unmarked sector of a stable arena under light conditions. Control rats were trained in the same context as the experimental rats either without (Control-noUS) or with shocks (Control-US) that were delivered in a random, noncontingent manner for three days...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685776/the-false-positive-responses-of-analgesic-drugs-to-the-intradermal-serotonin-and-compound-48-80-induced-scratches-as-an-animal-model-of-itch
#9
Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin
Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685775/effects-of-social-stress-and-clomipramine-on-emotional-memory-in-mice
#10
Aranzazu Duque, Concepción Vinader-Caerols, Santiago Monleón
We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study. Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed+saline and stressed+clomipramine...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685774/rat-white-matter-injury-model-induced-by-endothelin-1-injection-technical-modification-and-pathological-evaluation
#11
Hideaki Ono, Hideaki Imai, Satoru Miyawaki, Hirofumi Nakatomi, Nobuhito Saito
White matter injury is an important cause of functional disability of the brain. We comprehensively analyzed a modified endothelin-1 (ET‑1) injection-induced white matter injury model in the rat which is very valuable for investigating the underlying mechanisms of subcortical ischemic stroke. ET-1 was stereotactically injected into the internal capsule of the rat. To avoid complications with leakage of ET-1 into the lateral ventricle, the safest trajectory angle to the target was established. Rats with white matter injury were extensively evaluated for structural changes and functional sequelae, using motor function tests, magnetic resonance (MR) imaging, histopathology evolution, volume estimation of the lesion, and neuroanatomical identification of affected neurons using the retrograde tracer hydroxystilbamidine...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685773/continuous-mptp-intoxication-in-the-g%C3%A3-ttingen-minipig-results-in-chronic-parkinsonian-deficits
#12
Mette Slot Nielsen, Andreas Nørgaard Glud, Arne Møller, Poul Mogensen, Dirk Bender, Jens Christian Sørensen, Doris Doudet, Carsten Reidies Bjarkam
Parkinson's disease (PD) is a common neurodegenerative disorder, resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Neuroprotective therapies in PD are still not available, perhaps because animal models do not imitate the chronic and progressive nature of the clinical state of PD. To address this, we performed a feasibility study aimed at establishing a chronic non-primate large animal PD model in Göttingen minipigs based on continuous infusion of the neurotoxin 1-methyl-4-phenyl‑1,2,3,6-tetrahydropyridine (MPTP)...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685772/the-effects-of-edaravone-in-ketamine-induced-model-of-mania-in-rats
#13
Filiz Civil Arslan, Ahmet Tiryaki, Mehmet Yıldırım, Evrim Özkorumak, Ahmet Alver, İlkay Keleş Altun, İmran İnce, Öznur Gedikli
Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685771/effects-of-repetitive-transcranial-magnetic-stimulation-on-non-veridical-decision-making
#14
Jaan Tulviste, Elkhonon Goldberg, Kenneth Podell, Talis Bachmann
We test the emerging hypothesis that prefrontal cortical mechanisms involved in non-veridical decision making do not overlap with those of veridical decision making. Healthy female subjects performed an experimental task assessing free choice, agent-centered decision making (The Cognitive Bias Task) and a veridical control task related to visuospatial working memory (the Moving Spot Task). Transcranial magnetic stimulation (TMS) was applied to the left and right dorsolateral prefrontal cortex (DLPFC) using 1 Hz and 10 Hz (intermittent) rTMS and sham protocols...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685770/high-dose-1-25-dihydroxyvitamin-d-supplementation-elongates-the-lifespan-of-huntington-s-disease-transgenic-mice
#15
Máté Fort Molnár, Rita Török, Levente Szalárdy, Evelin Sümegi, László Vécsei, Péter Klivényi
Huntington's disease is an autosomal dominant progressive neurodegenerative disease, which results in a decreased quality of life and an early death. A high prevalence of vitamin D deficiency was first described in a 2013 study in patients with manifest Huntington's disease, where serum vitamin D level was found to be associated with motor capabilities of the patients. Our objective was to investigate the effect of a high-dose vitamin D3 supplementation on a transgenic mouse model of Huntington's disease. Our study was performed on N171-82Q Huntington's disease transgenic mice in age- and gender-matched groups...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685769/aberrant-changes-of-somatostatin-and-neuropeptide-y-in-brain-of-a-genetic-rat-model-for-epilepsy-tremor-rat
#16
Xiaoxue Xu, Feng Guo, Xinze Cai, Jun Yang, Jiuhan Zhao, Dongyu Min, Qianhui Wang, Liying Hao, Jiqun Cai
Excessive excitation or loss of inhibitory neurotransmission has been closely related to epileptic activity. Somatostatin (SST) and Neuropeptide Y (NPY) are members of endogenous neuropeptides which are recognized as important modulator of classical neurotransmitter, distributed abundantly in mammalian central nervous system. Abnormal expression of these two neuropeptides evidenced in some epileptic models highlights the relevance of SST or NPY in the pathogenesis of epilepsy. The tremor rat (TRM) is a genetic epileptic animal model which can manifest tonic convulsions without any external stimuli...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373953/somatic-and-dendritic-perforated-patch-recordings-reveal-b-adrenergic-receptor-induced-depolarization-in-medial-prefrontal-cortex-pyramidal-neurons
#17
Bartłomiej Szulczyk
The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of beta1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate cyclase inhibitor SQ 22536...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373952/prolonged-activity-evokes-potentiation-and-the-sag-phenomenon-in-slow-motor-units-of-rat-soleus
#18
Hanna Drzymała-Celichowska, Rositsa Raikova, Piotr Krutki
Slow motor units (MUs) have no sag in their unfused tetani. This study in anesthetized rats shows that the sag can be observed in slow soleus MUs after prolonged activity. Twitches and unfused tetanic contractions were recorded from male (n=35) and female (n=39) MUs before and after the four minutes of the fatigue test (trains of 13 pulses at 40 Hz repeated every second). After this activity twitch contractions potentiated and a shift in the steep part of the force-frequency curve towards lower frequencies was observed in both sexes...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373951/effects-of-harmonics-on-aesthetic-judgments-of-music-an-erp-study-involving-laypersons-and-experts
#19
Marta Jaśkiewicz, Piotr Francuz, Emilia Zabielska-Mendyk, Dariusz Zapała, Paweł Augustynowicz
The purpose of the study was to test whether aesthetic judgments of music are affected by expertise or harmonic violation of musical sequences. The participants were 14 musical experts and 13 laypersons; they were asked to judge the beauty and correctness of extracts from J. S. Bach's chorales. Experts and laypersons showed different late positive potential (LPP) responses to the appraisal of correctness. LPP also proved to be sensitive to the extent to which the extracts violated harmonic expectations. The relationship between the early right anterior negativity potential (ERAN) and the harmonic correctness of chords was similar in laypersons and experts...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373950/surgical-injury-induced-early-neocortical-microvascular-changes-and-characteristics-of-the-cells-populating-the-peri-lesion-zone
#20
Dorota Sulejczak, Stanisław J Chrapusta, Wojciech Kozłowski, Małgorzata Frontczak-Baniewicz
Adult mammalian brain contains a number of specialized neurovascular structures termed "niches" that act as sources of neuronal cells throughout the individual's life. Some of the niches generate neurons to satisfy the need for 'replacement' neurons within the same or closely located brain structures, whereas the other can provide such cells for more distant destinations in the brain. A common characteristic of known neurovascular niches is the presence of a complex 3-dimensional network of basal lamina processes, called fractones...
2016: Acta Neurobiologiae Experimentalis
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