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Acta Neurobiologiae Experimentalis

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https://www.readbyqxmd.com/read/27685777/spatial-memory-formation-differentially-affects-c-fos-expression-in-retrosplenial-areas-during-place-avoidance-training-in-rats
#1
Monika Malinowska, Monika Niewiadomska, Malgorzata Wesierska
The retrosplenial cortex is involved in spatial memory function, but the contribution of its individual areas is not well known. To elucidate the involvement of retrosplenial cortical areas 29c and 30 in spatial memory, we analyzed the expression of c-Fos in these areas in the experimental group of rats that were trained in a spatial place avoidance task, i.e. to avoid shocks presented in an unmarked sector of a stable arena under light conditions. Control rats were trained in the same context as the experimental rats either without (Control-noUS) or with shocks (Control-US) that were delivered in a random, noncontingent manner for three days...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685776/the-false-positive-responses-of-analgesic-drugs-to-the-intradermal-serotonin-and-compound-48-80-induced-scratches-as-an-animal-model-of-itch
#2
Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin
Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685775/effects-of-social-stress-and-clomipramine-on-emotional-memory-in-mice
#3
Aranzazu Duque, Concepción Vinader-Caerols, Santiago Monleón
We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study. Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed+saline and stressed+clomipramine...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685774/rat-white-matter-injury-model-induced-by-endothelin-1-injection-technical-modification-and-pathological-evaluation
#4
Hideaki Ono, Hideaki Imai, Satoru Miyawaki, Hirofumi Nakatomi, Nobuhito Saito
White matter injury is an important cause of functional disability of the brain. We comprehensively analyzed a modified endothelin-1 (ET‑1) injection-induced white matter injury model in the rat which is very valuable for investigating the underlying mechanisms of subcortical ischemic stroke. ET-1 was stereotactically injected into the internal capsule of the rat. To avoid complications with leakage of ET-1 into the lateral ventricle, the safest trajectory angle to the target was established. Rats with white matter injury were extensively evaluated for structural changes and functional sequelae, using motor function tests, magnetic resonance (MR) imaging, histopathology evolution, volume estimation of the lesion, and neuroanatomical identification of affected neurons using the retrograde tracer hydroxystilbamidine...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685773/continuous-mptp-intoxication-in-the-g%C3%A3-ttingen-minipig-results-in-chronic-parkinsonian-deficits
#5
Mette Slot Nielsen, Andreas Nørgaard Glud, Arne Møller, Poul Mogensen, Dirk Bender, Jens Christian Sørensen, Doris Doudet, Carsten Reidies Bjarkam
Parkinson's disease (PD) is a common neurodegenerative disorder, resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Neuroprotective therapies in PD are still not available, perhaps because animal models do not imitate the chronic and progressive nature of the clinical state of PD. To address this, we performed a feasibility study aimed at establishing a chronic non-primate large animal PD model in Göttingen minipigs based on continuous infusion of the neurotoxin 1-methyl-4-phenyl‑1,2,3,6-tetrahydropyridine (MPTP)...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685772/the-effects-of-edaravone-in-ketamine-induced-model-of-mania-in-rats
#6
Filiz Civil Arslan, Ahmet Tiryaki, Mehmet Yıldırım, Evrim Özkorumak, Ahmet Alver, İlkay Keleş Altun, İmran İnce, Öznur Gedikli
Bipolar disorder is a chronic disease characterized by recurring episodes of mania and depression that can lead to disability. This study investigates the protective effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a drug with well-known antioxidant properties, in a model of mania induced by ketamine in rats. Locomotor activity was assessed in the open-field test. Superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) levels were measured in order to evaluate oxidative damage in the rat hippocampus and prefrontal cortex...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685771/effects-of-repetitive-transcranial-magnetic-stimulation-on-non-veridical-decision-making
#7
Jaan Tulviste, Elkhonon Goldberg, Kenneth Podell, Talis Bachmann
We test the emerging hypothesis that prefrontal cortical mechanisms involved in non-veridical decision making do not overlap with those of veridical decision making. Healthy female subjects performed an experimental task assessing free choice, agent-centered decision making (The Cognitive Bias Task) and a veridical control task related to visuospatial working memory (the Moving Spot Task). Transcranial magnetic stimulation (TMS) was applied to the left and right dorsolateral prefrontal cortex (DLPFC) using 1 Hz and 10 Hz (intermittent) rTMS and sham protocols...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685770/high-dose-1-25-dihydroxyvitamin-d-supplementation-elongates-the-lifespan-of-huntington-s-disease-transgenic-mice
#8
Máté Fort Molnár, Rita Török, Levente Szalárdy, Evelin Sümegi, László Vécsei, Péter Klivényi
Huntington's disease is an autosomal dominant progressive neurodegenerative disease, which results in a decreased quality of life and an early death. A high prevalence of vitamin D deficiency was first described in a 2013 study in patients with manifest Huntington's disease, where serum vitamin D level was found to be associated with motor capabilities of the patients. Our objective was to investigate the effect of a high-dose vitamin D3 supplementation on a transgenic mouse model of Huntington's disease. Our study was performed on N171-82Q Huntington's disease transgenic mice in age- and gender-matched groups...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27685769/aberrant-changes-of-somatostatin-and-neuropeptide-y-in-brain-of-a-genetic-rat-model-for-epilepsy-tremor-rat
#9
Xiaoxue Xu, Feng Guo, Xinze Cai, Jun Yang, Jiuhan Zhao, Dongyu Min, Qianhui Wang, Liying Hao, Jiqun Cai
Excessive excitation or loss of inhibitory neurotransmission has been closely related to epileptic activity. Somatostatin (SST) and Neuropeptide Y (NPY) are members of endogenous neuropeptides which are recognized as important modulator of classical neurotransmitter, distributed abundantly in mammalian central nervous system. Abnormal expression of these two neuropeptides evidenced in some epileptic models highlights the relevance of SST or NPY in the pathogenesis of epilepsy. The tremor rat (TRM) is a genetic epileptic animal model which can manifest tonic convulsions without any external stimuli...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373953/somatic-and-dendritic-perforated-patch-recordings-reveal-b-adrenergic-receptor-induced-depolarization-in-medial-prefrontal-cortex-pyramidal-neurons
#10
Bartłomiej Szulczyk
The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of beta1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate cyclase inhibitor SQ 22536...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373952/prolonged-activity-evokes-potentiation-and-the-sag-phenomenon-in-slow-motor-units-of-rat-soleus
#11
Hanna Drzymała-Celichowska, Rositsa Raikova, Piotr Krutki
Slow motor units (MUs) have no sag in their unfused tetani. This study in anesthetized rats shows that the sag can be observed in slow soleus MUs after prolonged activity. Twitches and unfused tetanic contractions were recorded from male (n=35) and female (n=39) MUs before and after the four minutes of the fatigue test (trains of 13 pulses at 40 Hz repeated every second). After this activity twitch contractions potentiated and a shift in the steep part of the force-frequency curve towards lower frequencies was observed in both sexes...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373951/effects-of-harmonics-on-aesthetic-judgments-of-music-an-erp-study-involving-laypersons-and-experts
#12
Marta Jaśkiewicz, Piotr Francuz, Emilia Zabielska-Mendyk, Dariusz Zapała, Paweł Augustynowicz
The purpose of the study was to test whether aesthetic judgments of music are affected by expertise or harmonic violation of musical sequences. The participants were 14 musical experts and 13 laypersons; they were asked to judge the beauty and correctness of extracts from J. S. Bach's chorales. Experts and laypersons showed different late positive potential (LPP) responses to the appraisal of correctness. LPP also proved to be sensitive to the extent to which the extracts violated harmonic expectations. The relationship between the early right anterior negativity potential (ERAN) and the harmonic correctness of chords was similar in laypersons and experts...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373950/surgical-injury-induced-early-neocortical-microvascular-changes-and-characteristics-of-the-cells-populating-the-peri-lesion-zone
#13
Dorota Sulejczak, Stanisław J Chrapusta, Wojciech Kozłowski, Małgorzata Frontczak-Baniewicz
Adult mammalian brain contains a number of specialized neurovascular structures termed "niches" that act as sources of neuronal cells throughout the individual's life. Some of the niches generate neurons to satisfy the need for 'replacement' neurons within the same or closely located brain structures, whereas the other can provide such cells for more distant destinations in the brain. A common characteristic of known neurovascular niches is the presence of a complex 3-dimensional network of basal lamina processes, called fractones...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373949/pharmacokinetics-and-pharmacodynamics-of-a-novel-acetylcholinesterase-inhibitor-dmng-3
#14
Zhang Xin-Guo, Fei Kou, Ma Guo-Di, Peng Tang, Yang Zhong-Duo
DMNG-3(3β-Methyl-[2-(4-nitrophenoxy)ethyl]-amino]con-5-enine), is a new and the potentially most potent acetylcholinesterase inhibitor recently obtained from conessine by N-demethylation and nucleophilic substitution reaction. In the present study, a step-down passive avoidance test was used to investigate whether DMNG-3 could modulate impairment of learning and memory induced by scopolamine, and a high performance liquid chromatography(HPLC) method for the determination of DMNG-3 in biological samples was applied to study its pharmacokinetics and tissues distribution...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373948/inhibition-of-neuronal-and-inducible-nitric-oxide-synthase-does-not-affect-the-analgesic-effects-of-nmda-antagonists-in-visceral-inflammatory-pain
#15
Dragana Srebro, Sonja Vučković, Milica Prostran
Previously we described the antinociceptive effect of magnesium sulfate and dizocilpine (MK-801) in the visceral and somatic rat models of pain. In the somatic model of pain, we established the influence of selective inhibitors of neuronal and inducible nitric oxide synthase on the antihyperalgesic effects of magnesium sulfate and dizocilpine. Therefore, the objective of the present study was to determine in the rat model of visceral pain whether same mechanisms are involved in the antinociceptive action of magnesium sulfate and dizocilpine...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373947/functional-correlates-of-brain-aging-beta-and-gamma-frequency-band-responses-to-age-related-cortical-changes
#16
Mario Christov, Juliana Dushanova
The brain as a system with gradually declined resources by age maximizes its performance by neural network reorganization for greater efficiency of neuronal oscillations in a given frequency band. Whether event-related high-frequency band responses are related to plasticity in neural recruitment contributed to the stability of sensory/cognitive mechanisms accompanying aging or are underlined pathological changes seen in aging brain remains unknown. Aged effect on brain electrical activity was studied in auditory discrimination task (low-frequency and high-frequency tone) at particular cortical locations in beta (β1: 12...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27373946/behavioral-verification-of-associative-learning-in-whiskers-related-fear-conditioning-in-mice
#17
Anita Cybulska-Kłosowicz
Fear-conditioning is one of the most widely used paradigms in attempts to unravel the processes and mechanisms underlying learning and plasticity. In most of the Pavlovian conditioning paradigms auditory stimulus is used as a conditioned stimulus (CS), but conditioning can be accomplished also to tactile CS. The whisker-to-barrel tactile system in mice offers convenient way to investigate the brain pathways and mechanisms of learning, and plasticity of the brain cortex. To support a claim that an animal learns during conditioning session and that the plastic changes are associative in nature, objective measures of behavior are necessary...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27102920/eeg-source-activity-during-processing-of-neutral-stimuli-in-subjects-with-anxiety-disorders
#18
Bartłomiej Gmaj, Piotr Januszko, Jan Kamiński, Ewa Drozdowicz, Maciej Kopera, Dorota Wołyńczyk-Gmaj, Waldemar Szelenberger, Marcin Wojnar
Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education) during performance of the Continuous Attention Task. We used low resolution electromagnetic tomography (LORETA) for evaluation of mechanisms of impaired cognitive performance in anxiety disorders. Analysis showed that patients with anxiety disorders committed more errors than the controls, had a short latency of P300 and higher amplitude of ERPs at all steps of stimulus processing...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27102919/testosterone-metabolism-a-possible-biological-underpinning-of-non-verbal-iq-in-intellectually-gifted-girls
#19
Jaroslava Durdiaková, Peter Celec, Jolana Laznibatová, Gabriel Minárik, Daniela Ostatníková
The extraordinary giftedness is apparently a unique manifestation of a mutual interconnection between genes and environment. One of the possible etiological factors of intellectual giftedness is testosterone which is believed to affect the brain organization and function. The aim of our study was to analyze associations between 2D:4D digit ratio (a proxy of prenatal testosterone) and/or salivary testosterone levels with non-verbal IQ in intellectually gifted girls. Fifty-one girls with an age range of 10 to18 years and IQ scores higher than 130 were tested...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27102918/cerebellar-cortex-development-in-the-weaver-condition-presents-regional-and-age-dependent-abnormalities-without-differences-in-purkinje-cells-neurogenesis
#20
Joaquín Martí, María C Santa-Cruz, José P Hervás, Shirley A Bayer, Sandra Villegas
Ataxias are neurological disorders associated with the degeneration of Purkinje cells (PCs). Homozygous weaver mice (wv/wv) have been proposed as a model for hereditary cerebellar ataxia because they present motor abnormalities and PC loss. To ascertain the physiopathology of the weaver condition, the development of the cerebellar cortex lobes was examined at postnatal day (P): P8, P20 and P90. Three approaches were used: 1) quantitative determination of several cerebellar features; 2) qualitative evaluation of the developmental changes occurring in the cortical lobes; and 3) autoradiographic analyses of PC generation and placement...
2016: Acta Neurobiologiae Experimentalis
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