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Journal of Neurosurgical Sciences

Sirin Gandhi, Claudio Cavallo, Xiaochun Zhao, Evgenii Belykh, Michaela Lee, Seungwon Yoon, Mohamed Labib, Ali T Meybodi, Leandro B Moreira, Mark C Preul, Peter Nakaji
Over the last few decades, cerebrovascular surgery has gravitated towards a minimally invasive philosophy without compromising the foundational principles of patient safety and surgical efficacy. Enhanced radiosurveillance modalities and increased average life expectancy have resulted in an increased reported incidence of intracranial aneurysms. Although endovascular therapies have gained popularity in the recent years, microsurgical clipping continues to be of value in the management of these aneurysms owing to its superior occlusion rates, applicability to complex aneurysms and reduced retreatment rates...
September 10, 2018: Journal of Neurosurgical Sciences
Claudio Cavallo, Xiaochun Zhao, Hussam Abou Al-Shaar, Miriam Weiss, Sirin Gandhi, Evgenii Belykh, Ali Tayebi-Meybodi, Mohamed Labib, Mark C Preul, Peter Nakaji
INTRODUCTION: Intracerebral hemorrhage (ICH) is associated with a high rate of morbidity and mortality. Minimally-invasive surgery (MIS) has been increasingly used in recent years. We systematically reviewed the role of MIS in the acute management of ICH using various techniques. EVIDENCE ACQUISITION: A comprehensive electronic search for relevant articles was conducted on several relevant international databases, including PUBMED (Medline), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL)...
August 28, 2018: Journal of Neurosurgical Sciences
Evgenii Belykh, Claudio Cavallo, Sirin Gandhi, Xiaochun Zhao, Damjan Veljanoski, Mohammadhassan Izady Yazdanabadi, Nikolay L Martirosyan, Vadim A Byvaltsev, Jennifer Eschbacher, Mark C Preul, Peter Nakaji
INTRODUCTION: Precise identification of tumor margins is of the utmost importance in neuro-oncology. Confocal microscopy is capable of rapid imaging of fresh tissues at cellular resolution and has been miniaturized into handheld probe-based systems suitable use in for the operating room. We aimed to perform a literature review to provide an update on the current status of confocal laser endomicroscopy (CLE) technology for brain tumor surgery. METHODS: Review of literature...
August 28, 2018: Journal of Neurosurgical Sciences
Ignazio G Vetrano, Davide Bagatti, Roberto Cordella, Irene Tramacere, Vittoria Nazzi
BACKGROUND: Decompression and, when necessary, neurolysis in entrapment neuropathies of upper limbs are effective and safe procedures, but their correlation with the variation of compound muscle action potentials (CMAPs) is still unclear, based in particular on experimental models. In addition, there are few data regarding the efficacy of intraoperative neurophysiologic monitoring (IOM) to predict clinical early and late outcome after surgery in term of pain control and sensitive/motor recovery...
August 28, 2018: Journal of Neurosurgical Sciences
Francesco Acerbi, Francesco Restelli, Camilla De Laurentis, Jacopo Falco, Claudio Cavallo, Morgan Broggi, Julius Höhne, Karl-Michael Schebesch, Marco Schiariti, Paolo Ferroli
BACKGROUND: In recent years several techniques have been proposed with the aim of improving tumors visualization and extent of resection and, among them, the use of photosensitive dyes is gaining great interest. Regarding the application of the two most used dyes, 5-aminolevulinic acid (5-ALA) and sodium fluorescein (SF), there is still a lack of shared and established protocols among different centers. The main objective of the present study was to evaluate the current practice of fluorescence-guided techniques in neuro-oncological surgery in Europe...
July 17, 2018: Journal of Neurosurgical Sciences
Wolfgang Senker, Harald Stefanits, Matthias Gmeiner, Wolfgang Trutschnig, Christian Radl, Andreas Gruber
BACKGROUND: The impact of diabetes on spinal surgery has been studied extensively, but very few studies have focused on minimal access spinal technologies (MAST) and complication rates in patients suffering from Type 2 Diabetes (T2DM). Diabetes increases the risk of wound healing disorders, complication rate and length of stay in the hospital. We focused on the peri- and postoperative complications of MAST in an unselected consecutive population of 187 patients suffering from degenerative disorders lumbar spine disorders...
July 17, 2018: Journal of Neurosurgical Sciences
Tamara Maghathe, William K Miller, Luke Mugge, Tarek R Mansour, Jason Schroeder
INTRODUCTION: Pituitary adenomas (PAs) are primary central nervous system (CNS) tumors, accounting for as much as 25% of intracranial neoplasms. Although existing remedies show success in treating most PAs, treatment of invasive and non-functioning PAs, in addition to functioning PAs unresponsive to standard therapy, remains challenging. With the continually increasing understanding of biochemical pathways involved in tumorigenesis, immunotherapy stands as a promising alternative therapy for pituitary tumors that are resistant to standard therapy...
July 17, 2018: Journal of Neurosurgical Sciences
Shigeru Yamaguchi, Yukitomo Ishi, Hiroaki Motegi, Michinari Okamoto, Hiroyuki Kobayashi, Kenji Hirata, Yoshitaka Oda, Shinya Tanaka, Shunsuke Terasaka, Kiyohiro Houkin
BACKGROUND: Although newly diagnosed high-grade glioma patients in Japan can receive bevacizumab (BEV) as first-line chemotherapy, randomized clinical trials have not shown a survival benefit for BEV for these patients. In this study, we investigated whether selective add-on BEV for patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA) improves prognosis, in cases where tumors were continuously growing during radiotherapy concomitant with temozolomide (TMZ)...
July 9, 2018: Journal of Neurosurgical Sciences
Pietro Fiaschi, Bernarda Cagetti, Filippo Badaloni, Riccardo Padolecchia, Marco Pavanello, Valtero Valsania
No abstract text is available yet for this article.
June 27, 2018: Journal of Neurosurgical Sciences
Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Daisuke Haratake, Koji Arihiro, Hiroki Ueno, Ryo Shimomura, Yuji Akiyama, Kazuhiko Sugiyama, Masayasu Matsumoto, Kaoru Kurisu
No abstract text is available yet for this article.
October 2018: Journal of Neurosurgical Sciences
Timothée Abaziou, Ségolène Mrozek, Mohamed Srairi, Francois Gaussiat, Fouad Marhar, Diane Osinski, Rémi Menut, Claire Larcher, Vincent Atthar, David Brauge, Jean C Sol, Olivier Fourcade, Thomas Geeraerts
No abstract text is available yet for this article.
October 2018: Journal of Neurosurgical Sciences
Corrado Iaccarino, Alessandro Carretta, Federico Nicolosi, Carlotta Morselli
About 5.48 million people are estimated to suffer from severe traumatic brain injury (TBI) each year (73 cases per 100,000 people). The WHO estimates that almost 90% of deaths due to injuries occur in low- and middle-income countries (LMICs), where the 85% of population live. Of these trauma-related deaths TBI is the main cause of one-third to one-half and represents the greatest cause of death and disability globally among all trauma-related injuries. The primary causes of TBI vary by age, socioeconomic factors, and geographic region, so any planned interventions must take in account this variability...
October 2018: Journal of Neurosurgical Sciences
Stephen Honeybul
No abstract text is available yet for this article.
October 2018: Journal of Neurosurgical Sciences
Rathin Pujari, Peter J Hutchinson, Angelos G Kolias
Traumatic brain injury (TBI) remains a leading cause of mortality and disability worldwide. Surgical intervention is one of the main pillars of TBI management. The mainstay of treatment for substantial intracranial hematomas is surgical evacuation. In addition, patients with TBI may have brain swelling and increased intracranial pressure. If the latter is refractory to medical management, surgical interventions can be helpful. In this review we seek to outline the major tenets of the surgical management of TBI...
October 2018: Journal of Neurosurgical Sciences
Stephen Honeybul
There is now no little doubt that decompressive craniectomy can reduce mortality following severe traumatic brain injury. However, the concern has always been that the reduction in mortality comes at the cost of an increase in the number of survivors with severe neurological disability. It was these concerns that prompted investigators to conduct a number of large multicenter randomized trials investigating surgical efficacy of the procedure. Whilst the results of these trials have confirmed the survival benefit that can be achieved this has only been achieved by increasing the number of survivors with severe disability and dependency...
October 2018: Journal of Neurosurgical Sciences
Ruth A O'leary, Alistair D Nichol
Traumatic brain injury is a leading cause of morbidity and mortality globally, particularly among young people, with significant social and economic effects. The World Health Organization (WHO) estimates that more than five million people die each year from traumatic injuries worldwide. While public health initiatives such as seatbelts and airbags have had a major impact, it will be impossible to prevent traumatic brain injury.Therefore, it is important that we understand the pathophysiology of secondary brain injury to be able to effectively treat our patient and also to develop novel targets of future interventions...
October 2018: Journal of Neurosurgical Sciences
Masoom Desai, Abhi Jain
Traumatic brain injury (TBI) has a high incidence worldwide and is associated with significant morbidity and mortality. TBI has enduring implications in several domains and limits overall quality of life even in the survivors. Assessment of failures of different strategies attempted at improving outcomes in traumatic brain injury is required. Several neuroprotective strategies have been studied to limit the morbidity and mortality associated with TBI. Various approaches, both pharmacologic and surgical, have been tried...
October 2018: Journal of Neurosurgical Sciences
Anna T Mazzeo, Deepak Gupta
Traumatic brain injury can be defined as the most complex disease in the most complex organ. When an acute brain injury occurs, several pathophysiological cascades are triggered, leading to further exacerbation of the primary damage. A number of events potentially occurring after TBI can compromise the availability or utilization of energy substrates in the brain, ultimately leading to brain energy crisis. The frequent occurrence of secondary insults in the acute phase after TBI, such as intracranial hypertension, hypotension, hypoxia, hypercapnia, hyperthermia, seizures, can then increase cerebral damage, and adversely affect outcome...
October 2018: Journal of Neurosurgical Sciences
Alba Scerrati, Silvia De Rosa, Lorenzo Mongardi, Michele A Cavallo, Giorgio Trapella, Pasquale De Bonis
Severe traumatic brain injury (STBI) is characterized by a primary injury which cannot be reversed and a secondary injury that can be prevented or reversed. Management of STBI patients in intensive care mainly aims at preventing the secondary injury. Treatment aims to: reducing ICP pressure (that can result in an ischemic insult); avoiding hypotension, hyperthermia, or hypoxemia; maintaining a normal electrolytes homeostasis; treating the autonomic dysfunction syndrome, coagulopathies, acute kidney injury and maintaining an adequate nutrition...
October 2018: Journal of Neurosurgical Sciences
Kwok M Ho
Predicting long-term outcome after severe traumatic brain injury (TBI) is difficult, but accurate assessment is paramount for both families of the patients and medical decision-making, as well as quality assurance or research purposes. Many important prognostic factors for patients with severe TBI have been identified, but most - if not all - including the Glasgow Coma Score and magnetic resonance imaging are not accurate enough to be used alone to predict patient outcomes. Clinicians should also be wary about how their predictions and decision-making can be affected by heuristics and cognitive biases...
October 2018: Journal of Neurosurgical Sciences
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