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Journal of Neurosurgical Sciences

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https://www.readbyqxmd.com/read/27901327/stem-cell-therapy-for-sequestering-neuroinflammation-in-traumatic-brain-injury-an-update-on-exosome-targeting-to-the-spleen
#1
Marci G Crowley, Michael G Liska, Cesar V Borlongan
Traumatic brain injury (TBI), manifests with acute and chronic cell death pathways leading to initial impacted injury and subsequent neurodegeneration. In particular, the secondary cell death, plagued by a massive and lingering neuroinflammatory response, contributes significantly to worsening outcomes of the progressive TBI pathology. Fortunately, neuroinflammation also provides an opportunity for therapeutic interventions. Limited treatment options currently exist for the disease, but stem cell-based therapies offer promise in promoting neuroprotection and neuroregeneration by mitigating central neuroinflammation as well as modulating peripheral inflammation via the spleen...
November 30, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27901326/tuberculuma-sellae-meningiomas-a-systematic-review-of-transcranial-approaches-in-the-endoscopic-era
#2
Mazda Turel, Georgios Tsermoulas, Abdulmounem Yasssin-Kassab, Deven Reddy, Hugo Andrade-Barazarte, Lior Gonen, Gelareh Zadeh, Fred Gentili
INTRODUCTION: With the advent of skull base endoscopy, tuberculum sellae meningiomas (TSMs) are currently operated both from the traditional transcranial (TC) route as well as the extended endonasal endoscopic trasnssphenoidal approach (EETS). The aim of this study was to conduct a systematic review of TSMs excised via the TC route in the modern era when the EETS excision is gaining popularity. EVIDENCE ACQUISITION: We performed a systematic review in the medical literature following the PRISMA guidelines...
November 30, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27886158/recanalization-and-rupture-after-intracranial-aneurysm-treatment
#3
Emmanuel Costa, Geraldo R Vaz, Patrice Finet, Pierre Goffette, Marie A Docquier, Christian Raftopoulos
BACKGROUND: Treatment of intra cranial aneurysm (ICA) can sometimes required several procedures. The aim of this study is to analyze the risk of recanalization and rupture recurrence after ICA treatment by endovascular coiling (EVC) or surgical clipping (SC) on a very long follow-up. METHODS: Clinical data of 373 consecutive patients treated in our group between January 1996 and December 2006 as well by EVC as by SC for ruptured (RIA) or unruptured intracranial aneurysm (UIA), were reviewed...
November 25, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27886157/intraoperative-seizures-and-seizures-outcome-in-patients-underwent-awake-craniotomy
#4
Yang Yuan, Zhou Peizhi, Wang Xiang, Liu Yanhui, Liang Ruofei, Jiang Shu, Mao Qing
BACKGROUND: Awake craniotomies (AC) could reduce neurological deficits compared with patients under general anesthesia, however, intraoperative seizure is a major reason causing awake surgery failure. The purpose of the study was to give a comprehensive overview the published articles focused on seizure incidence in awake craniotomy. METHODS: Bibliographic searches of the EMBASE, MEDLINE,were performed to identify articles and conference abstracts that investigated the intraoperative seizure frequency of patients underwent AC...
November 25, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27879953/elective-laminectomy-and-excision-of-the-thoracic-spine-neoplasm-an-evaluation-of-early-outcomes
#5
Pavan S Upadhyayula, John K Yue, Erik I Curtis, Joseph D Ciacci
BACKGROUND: Laminectomy plus excision of spinal neoplasms is commonly performed. The current study examines risk profiles associated with elective laminectomies of benign, malignant primary, and secondary/metastatic neoplasms of the thoracic spine. METHODS: Adult patients undergoing elective thoracic laminectomy and excision of spinal neoplasm were abstracted from ACS-NSQIP years 2011-2014. Patients were classified into three cohorts: benign primary, malignant primary, secondary/metastatic...
November 23, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27879952/allograft-versus-autograft-in-cervical-and-lumbar-spinal-fusions-an-examination-of-operative-time-length-of-stay-surgical-site-infection-and-blood-transfusions
#6
Meghan E Murphy, Brandon A McCutcheon, Jennifer Grauberger, Daniel Shepherd, Patrick R Maloney, Lorenzo Rinaldo, Panagiotis Kerezoudis, Jeremy L Fogelson, Ahmad Nassr, Mohamad Bydon
BACKGROUND: Autograft harvesting for spine arthrodesis has been associated with longer operative times and increased blood loss. Allograft compared to autograft in spinal fusions has not been studied in a multicenter cohort. METHODS: Patients enrolled in the ACS-NSQIP registry between 2012 and 2013 who underwent cervical or lumbar spinal fusion with either allograft or autograft through a separate incision were included for analysis. The primary outcomes of interest were operative time, length of stay, blood transfusion, and surgical site infection (SSI)...
November 23, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27879951/multidisciplinary-management-of-spontaneous-spinal-infections-there-is-a-correlation-between-timing-type-of-treatment-and-outcome-a-multivariate-analysis-of-an-observational-cohort-study
#7
Alessandro Landi, Alessandro DI Bartolomeo, Nicola Marotta, Giancarlo Iaiani, Maurizio Domenicucci, Massimo Chiara, Maurizio Salvati, Roberto Delfini
BACKGROUND: Spontaneous Spinal Infections SSI represent a rare and serious pathological entity. We've tried to study a correlation between type of treatment, timing of treatment and clinical outcome through a multivariate analysis of an observational cohort study with the aim to define what is the optimal clinico-therapeutic management. METHODS: We perform a retrospective observational cohort study on all consecutive patients observed in our Institute in a period of 13 years; From 2001 to 2014 we enrolled 50 consecutive patients with symptomatic spontaneous spinal infections (no previous surgery or recent infection in other site), confirmed with diagnostic imaging...
November 23, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27854112/large-traumatic-basal-ganglia-hematoma-surgical-treatment-versus-conservative-management
#8
Humain Baharvahdat, Babak Ganjifar, Hamid Etemadrezaie, Ali Gorji
BACKGROUND: Traumatic basal ganglia hematomas (TBGHs) are uncommon events in patients with closed head injuries. The overall prognosis is poor, particularly when large hematoma exists. This study was designed to compare surgical evacuation through transsylvian-transinsular approach with conservative management in large TBGHs. METHODS: Thirty-two patients, admitted between July 2002 and July 2013, with closed head injury and TBGH more than 25 ml were included in this study...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27854111/the-risk-of-hypotension-and-seizures-in-patients-receiving-prophylactic-anti-epileptic-drugs-for-supratentorial-craniotomy
#9
Julius Höhne, Karl M Schebesch, Christian Ott, Alexander Brawanski, Max Lange
BACKGROUND: Perioperative seizure prophylaxis with antiepileptic drugs (AED) has been advocated in patients undergoing supratentorial craniotomy. The practice remains controversial. The reasoning presupposes that the possibility of an adverse drug reaction from the AED is lower than the probability of harm from a seizure. Even short periods of hypotension during the operation can lead to acute kidney and myocardial injury. We retrospectively evaluated cardiovascular effects and tolerability of Levetiracetam (LEV) alone, LEV and Lacosamid (LCM) as compared to Phenytoin (PHT)...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27854110/association-between-carotid-artery-tortuosity-and-carotid-dissection-a-case-control-study
#10
Sarasa T Kim, Waleed Brinjikji, Vance T Lehman, Carrie M Carr, Patrick H Luetmer, Charlotte H Rydberg
BACKGROUND: Carotid artery dissections have long been associated with compromise of the structural integrity of the arterial wall from heritable connective-tissue disorders, hypertension, and trauma. However, an association between spontaneous internal carotid artery dissection and tortuous or redundant carotid anatomy has not been fully explored. METHODS: Patients with CTA confirmed spontaneous cervical internal carotid artery dissections were compared to a group of age and sex matched controls who also received CTA of the neck...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27854109/effect-of-mono-or-bisegmental-lordosizing-fusion-on-short-term-global-and-index-sagittal-balance-a-radiographic-study
#11
Enrico Tessitore, Ilaria Melloni, Oliver P Gautschi, Gianluigi Zona, Karl Schaller, Pedro Berjano
BACKGROUND: Sagittal balance is widely recognized as an important outcome factor in reconstructive spinal surgery for lumbar degenerative conditions. However, its role in short segmental fixation is unknown. The aim of this study is to evaluate the preoperative and short-term postoperative spino-pelvic balance after short (1 or 2 levels) lordosizing lumbar fusion for degenerative disc disease (DDD). MATERIALS AND METHODS: Twenty-six consecutive patients (13 males and 13 females) undergoing mono- or bisegmental lordosizing lumbar fusion (XLIF/TLIF) for lumbar DDD were included in the study...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27854108/the-default-mode-network-a-neuroimaging-based-objective-biomarker-and-predictor-for-neuromodulation-treatment-of-migraine
#12
Thomas M Kinfe
No abstract text is available yet for this article.
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27849112/natural-history-of-untreated-unruptured-intracranial-aneurysms-in-the-elderly
#13
Lorenzo Rinaldo, Daniel L Shepherd, Meghan E Murphy, Roanna L Vine, Robert D Brown, Alejandro A Rabinstein, Giuseppe Lanzino
BACKGROUND: The effect of age on risk of intracranial aneurysm rupture is not well understood. We investigated the clinical course of patients 65 years and older with conservatively managed unruptured intracranial aneurysms (UIA) and determined risk factors for rupture in this population. METHODS: We reviewed prospectively collected data on baseline characteristics and long- term follow-up for patients aged 65 years and older with an UIA that were initially managed with observation...
November 16, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27845506/surgical-treatments-of-spinal-metastases-analysis-of-prognostic-factors-during-a-seven-year-experience
#14
Mauro Dobran, Maurizio Iacoangeli, Denise Brunozzi, Davide Nasi, Lucia Di Somma, Elisa Moriconi, Roberto Colasanti, Maurizio Gladi, Massimo Scerrati
No abstract text is available yet for this article.
November 15, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27787488/surgical-management-of-spinal-metastatic-disease
#15
Andrew A Fanous, Andrew J Fabiano
Spinal metastatic disease is a common occurrence in oncology. Spinal metastases may result in pain, spinal deformity, and neurologic deterioration. Surgical intervention is a key component in the effective management of spinal metastatic disease. The principles of neural decompression and spinal stabilization are hallmarks of the surgical care for patients with metastatic spinal disease. Several classification systems exist for spinal metastatic disease to aid in assessing preoperative spinal instability and the need for operative intervention...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27787487/minimally-invasive-spine-surgery-in-spinal-infections-an-up-date
#16
Francisco Verdú López, Vicente Vanaclocha Vanaclocha, Juan D Mayorga-Villa
Although spinal infections have always been present recently their incidence has increased, in partly fostered by the advances in medicine (i.e. compromised 10 immunity, chronic diseases, increasingly complex spinal procedures...) and increased life expectancy. Using PubMed for this systematic review, the main spine infections types will be addressed focusing in the minimally invasive surgical techniques that can be used in their treatment. Spontaneous and iatrogenic pyogenic and non-pyogenic spine infections can be treated in many different ways depending on their extension and 15 location as well as on their causative microorganisms...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27787486/minimally-invasive-cervical-spine-surgery
#17
Branko Skovrlj, Sheeraz A Qureshi
AIM: Degenerative disorders of the cervical spine requiring surgical intervention have become increasingly more common over the past decade. Traditionally, open surgical approaches have been the mainstay of surgical treatment. More commonly, minimally invasive techniques are being developed with the intent to decrease surgical morbidity and iatrogenic spinal instability. This study will review four minimally invasive cervical techniques that have been increasingly utilized in the treatment of degenerative cervical spine disease...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27787485/moyamoya-vasculopathy-shows-a-genetic-mutational-gradient-decreasing-from-east-to-west
#18
Alessandro Raso, Roberto Biassoni, Samantha Mascelli, Paolo Nozza, Elisabetta Ugolotti, Eddi DI Marco, Patrizia DE Marco, Elisa Merello, Armando Cama, Marco Pavanello, Valeria Capra
BACKGROUND: Moyamoya disease (MMD) is a chronic, occlusive cerebrovascular disease characterized by bilateral steno- occlusive changes at the terminal portion of the internal carotid arteries and an abnormal vascular network at the base of the brain determining stroke in children. Patients with a similar vasculopathy and associated conditions are affected by the moyamoya syndrome (MMS). Most of the studies focused on MMD were carried out on East-Asian population. Ring Finger 213 (RNF213) has been identified as the strongest susceptibility gene for MMD in East-Asian people...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27759739/five-year-medical-expenses-of-central-cord-syndrome-analysis-using-a-national-cohort
#19
Li F Chen, Hsuan K Chang, Yu C Chen, Jau C Wu, Wen C Huang, Henrich Cheng, Su S Lo
BACKGROUND: This study aimed to investigate the medical expenses and outcomes of central cord syndrome (CCS), comparing patients who received surgical and non-surgical management. METHODS: Using a 14-year nationwide database in Taiwan, this study followed-up all patients of CCS at least 5 years. The incidence rates, medical expenses, permanently disabled spinal cord injury (SCI), and mortality rates were compared for patients who underwent surgery and those who were managed conservatively...
October 19, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27759738/the-relationship-between-il-6-et-1-and-cerebral-vasospasm-in-experimental-rabbit-subarachnoid-hemorrhage
#20
Davide Croci, Edin Nevzati, Hiroki Danura, Salome Schöpf, Javier Fandino, Serge Marbacher, Carl Muroi
BACKGROUND: In subarachnoid hemorrhage (SAH), occurrence of cerebral vasospasm (CVS) mediated by endothelin (ET)-1 might be a result of a compartmental inflammatory response with interleukin (IL)-6 release. We aim to investigate the relationship between ET-1 and IL-6 in association of CVS. METHODS: A total of 24 New Zealand white rabbits where randomly allocated into 3 groups: SAH (n=10), IL-6 (n=10), and sham (n=4). SAH was induced by a closed cranium extracranial-intracranial shunt model...
October 19, 2016: Journal of Neurosurgical Sciences
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