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Topics in Current Chemistry

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https://www.readbyqxmd.com/read/27222903/chemoselectivity-and-stereoselectivity-have-been-key-factors-in-the-development-of-fine-organic-synthesis-introduction
#1
EDITORIAL
Takeo Kawabata
No abstract text is available yet for this article.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26920160/hypervalent-iodine-induced-oxidative-couplings-new-metal-free-coupling-advances-and-their-applications-in-natural-product-syntheses
#2
Toshifumi Dohi, Yasuyuki Kita
Recently, hypervalent iodine reagents have been extensively used in organic synthesis. A variety of reactions available for natural product syntheses have been developed using phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA), and other iodine(III) and (V) reagents. These reactions are expected to have applications in pharmaceutical and agrochemical processes because of their safety, mild reaction conditions, and high yields of pure products. Under such considerations, this chapter focuses on the oxidative coupling reactions of hypervalent iodine reagents found in total syntheses of biologically active natural products and their related compounds...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26809623/halogen-bonding-in-hypervalent-iodine-compounds
#3
Luca Catalano, Gabriella Cavallo, Pierangelo Metrangolo, Giuseppe Resnati, Giancarlo Terraneo
Halogen bonds occur when electrophilic halogens (Lewis acids) attractively interact with donors of electron density (Lewis bases). This term is commonly used for interactions undertaken by monovalent halogen derivatives. The aim of this chapter is to show that the geometric features of the bonding pattern around iodine in its hypervalent derivatives justify the understanding of some of the longer bonds as halogen bonds. We suggest that interactions directionality in ionic and neutral λ(3)-iodane derivatives is evidence that the electron density distribution around iodine atoms is anisotropic, a region of most positive electrostatic potential exists on the extensions of the covalent bonds formed by iodine, and these positive caps affect, or even determine, the crystal packing of these derivatives...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26809622/phenol-dearomatization-with-hypervalent-iodine-reagents
#4
Stéphane Quideau, Laurent Pouységu, Philippe A Peixoto, Denis Deffieux
This chapter highlights recent developments in phenol dearomatization using organoiodane reagents and a selection of applications in natural product synthesis.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26798866/preface
#5
Salvatore Sortino
No abstract text is available yet for this article.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26798865/preface-solar-energy-for-fuels
#6
Harun Tüysüz, Candace K Chan
No abstract text is available yet for this article.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26632623/preface
#7
Nicolas Ferré
No abstract text is available yet for this article.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26621058/organoiodine-iii-reagents-as-active-participants-and-ligands-in-transition-metal-catalyzed-reactions-iodosylarenes-and-imino-iodoarenes
#8
John D Protasiewicz
This chapter overviews the roles of transition metal complexes having the organoiodine(III) reagents iodosylarenes (ArIO) and (imino)iodoarenes (ArINR) as ligands in catalysis. Mechanistic implications are discussed.
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589511/phototherapeutic-release-of-nitric-oxide-with-engineered-nanoconstructs
#9
REVIEW
Aurore Fraix, Nino Marino, Salvatore Sortino
The multiple role nitric oxide (NO) plays in a number of physiological and pathophysiological processes has, over the last few years, stimulated a massive interest in the development of new strategies and methods for generating NO in a controlled way, with the exciting prospect of tackling important diseases. Photochemical precursors of NO are particularly suited to this end because light triggering permits an exquisite control of location and timing of NO delivery. Integration of NO photodonors within the structure of appropriate materials represents a key step in the fabrication of functional devices for phototherapeutic applications...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589510/diagnostic-and-therapeutic-applications-of-quantum-dots-in-nanomedicine
#10
REVIEW
Sukanta Kamila, Conor McEwan, David Costley, Jordan Atchison, Yinjie Sheng, Graham R C Hamilton, Colin Fowley, John F Callan
The interest in Quantum Dots as a class of nanomaterials has grown considerably since their discovery by Ekimov and Efros in the early 1980s. Although this early work focussed primarily on CdSe-based nanocrystals, the field has now expanded to include various classes of nanoparticles with different types of core, shell or passivation chemistry. Such differences can have a profound effect on the optical properties and potential biocompatibility of the resulting constructs. Although QDs have predominantly been used for imaging and sensing applications, more examples of their use as therapeutics are beginning to emerge...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589509/gold-based-nanomaterials-for-applications-in-nanomedicine
#11
REVIEW
Sumaira Ashraf, Beatriz Pelaz, Pablo del Pino, Mónica Carril, Alberto Escudero, Wolfgang J Parak, Mahmoud G Soliman, Qian Zhang, Carolina Carrillo-Carrion
In this review, an overview of the current state-of-the-art of gold-based nanomaterials (Au NPs) in medical applications is given. The unique properties of Au NPs, such as their tunable size, shape, and surface characteristics, optical properties, biocompatibility, low cytotoxicity, high stability, and multifunctionality potential, among others, make them highly attractive in many aspects of medicine. First, the preparation methods for various Au NPs including functionalization strategies for selective targeting are summarized...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589508/photoactivatable-nanostructured-surfaces-for-biomedical-applications
#12
REVIEW
Jiří Mosinger, Kamil Lang, Pavel Kubát
This review aims to summarize the current status of photoactivatable nanostructured film and polymeric nanofiber surfaces used in biomedical applications with emphasis on their photoantimicrobial activity, oxygen-sensing in biological media, light-triggered release of drugs, and physical or structural transformations. Many light-responsive functions have been considered as novel ways to alter surfaces, i.e., in terms of their reactivities and structures. We describe the design of surfaces, nano/micro-fabrication, the properties affected by light, and the application principles...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589507/inorganic-nanoparticles-for-photodynamic-therapy
#13
REVIEW
L Colombeau, S Acherar, F Baros, P Arnoux, A Mohd Gazzali, K Zaghdoudi, M Toussaint, R Vanderesse, C Frochot
Photodynamic therapy (PDT) is a well-established technique employed to treat aged macular degeneration and certain types of cancer, or to kill microbes by using a photoactivatable molecule (a photosensitizer, PS) combined with light of an appropriate wavelength and oxygen. Many PSs are used against cancer but none of them are highly specific. Moreover, most are hydrophobic, so are poorly soluble in aqueous media. To improve both the transportation of the compounds and the selectivity of the treatment, nanoparticles (NPs) have been designed...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589506/polymeric-nanoparticles-for-cancer-photodynamic-therapy
#14
REVIEW
Claudia Conte, Sara Maiolino, Diogo Silva Pellosi, Agnese Miro, Francesca Ungaro, Fabiana Quaglia
In chemotherapy a fine balance between therapeutic and toxic effects needs to be found for each patient, adapting standard combination protocols each time. Nanotherapeutics has been introduced into clinical practice for treating tumors with the aim of improving the therapeutic outcome of conventional therapies and of alleviating their toxicity and overcoming multidrug resistance. Photodynamic therapy (PDT) is a clinically approved, minimally invasive procedure emerging in cancer treatment. It involves the administration of a photosensitizer (PS) which, under light irradiation and in the presence of molecular oxygen, produces cytotoxic species...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589505/self-assembling-nanoparticles-of-amphiphilic-polymers-for-in-vitro-and-in-vivo-fret-imaging
#15
Jaume Garcia-Amorós, Sicheng Tang, Yang Zhang, Ek Raj Thapaliya, Françisco M Raymo
Self-assembling nanoparticles of amphiphilic polymers are viable delivery vehicles for transporting hydrophobic molecules across hydrophilic media. Noncovalent contacts between the hydrophobic domains of their macromolecular components are responsible for their formation and for providing a nonpolar environment for the encapsulated guests. However, such interactions are reversible and, as a result, these supramolecular hosts can dissociate into their constituents amphiphiles to release the encapsulated cargo...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26589504/luminescent-silica-nanoparticles-featuring-collective-processes-for-optical-imaging
#16
REVIEW
Enrico Rampazzo, Luca Prodi, Luca Petrizza, Nelsi Zaccheroni
The field of nanoparticles has successfully merged with imaging to optimize contrast agents for many detection techniques. This combination has yielded highly positive results, especially in optical and magnetic imaging, leading to diagnostic methods that are now close to clinical use. Biological sciences have been taking advantage of luminescent labels for many years and the development of luminescent nanoprobes has helped definitively in making the crucial step forward in in vivo applications. To this end, suitable probes should present excitation and emission within the NIR region where tissues have minimal absorbance...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26546327/aminations-with-hypervalent-iodine
#17
Kilian Muñiz
Recent progress in the area of hypervalent iodine-mediated and catalyzed amination reaction of hydrocarbons is reviewed. These reactions comprise processes under both intra and intermolecular control and include the functionalization of aromatic C-H bonds as well as conversion of sp-, sp(2)-, and sp(3)-hybridized carbon atoms. These developments demonstrate that hypervalent iodine(III) methodology has reached a high level in amination chemistry. The individual reactions are discussed with a focus on mechanistic details and emphasis is made to the underlying hypervalent iodine reagents, for which structural information is available...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26486138/organocatalytic-site-selective-acylation-of-carbohydrates-and-polyol-compounds
#18
Yoshihiro Ueda, Takeo Kawabata
Development and scope of conventionally difficult molecular transformation on site-selective acylation of carbohydrates and polyol compounds are described. A salient feature is that the site-selectivity can be controlled independently from the intrinsic reactivity of the substrate, i.e., catalyst-controlled selectivity. Therefore, some substrates undergo acylation with reversal of their intrinsic reactivity. The mechanistic aspects of catalyst-controlled site-selective acylation are discussed with the emphasis on the strategy relying on the accelerative reaction rather than the decelerative one...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26318485/alkynylation-with-hypervalent-iodine-reagents
#19
Jerome Waser
Alkynes are among the most versatile functional groups in organic synthesis. They are also frequently used in chemical biology and materials science. Whereas alkynes are traditionally added as nucleophiles into organic molecules, hypervalent iodine reagents offer a unique opportunity for the development of electrophilic alkyne synthons. Since 1985, alkynyliodonium salts have been intensively used for the alkynylation of nucleophiles, in particular soft carbon nucleophiles and heteroatoms. They have made an especially strong impact in the synthesis of highly useful ynamides...
2016: Topics in Current Chemistry
https://www.readbyqxmd.com/read/26318344/recent-advances-in-the-selective-oxidation-of-alkyl-c-h-bonds-catalyzed-by-iron-coordination-complexes
#20
Mercè Canta, Mònica Rodríguez, Miquel Costas
Selective and stereoretentive oxidation of alkyl C-H bonds has been described over the last decade by employing biologically inspired iron coordination complexes as catalysts and hydrogen peroxide as oxidant. Examples of catalyst dependent C-H site selectivity have started to appear. The current paper describes an account of these findings.
2016: Topics in Current Chemistry
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