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Journal of Nuclear Medicine Technology

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https://www.readbyqxmd.com/read/30413603/biodistribution-and-dosimetry-of-indigenous-131-i-rituximab-in-b-cell-lymphoma-pilot-study-estimating-patient-specific-dose-comparing-two-different-dosimetric-methods
#1
Aadil Adnan, Kamal Deep, Mythili Kameswaran, Dilip Nikam, S Chandrakala, Ashutosh Dash, Sharmila Banerjee, Sandip Basu
BACKGROUND: Cost-containment through indigenous development and production and its subsequent examination in clinical settings would be a pivotal step for bringing radioimmunotherapy (RIT) agents to more widespread clinical practice in non-Hodgkin's lymphoma (NHL) patients, especially in developing countries. AIMS and OBJECTIVES: To examine the biodistribution and dosimetry of indigenously developed and radiolabeled 131 I-Rituximab, using the monoclonal antibody of chimeric origin, in patients of B cell lymphoma for its potential use in RIT...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413602/improving-the-spatial-alignment-in-pet-ct-using-amplitude-based-respiratory-gated-pet-and-patient-specific-breathing-instructed-ct
#2
Charlotte S van der Vos, Antoi P W Meeuwis, Willem Grootjans, Lioe-Fee de Geus-Oei, Eric P Visser
Appropriate attenuation correction is important for accurate quantification of standardized uptake values (SUVs) in positron emission tomography (PET). Patient respiratory motion can introduce a spatial mismatch between respiratory-gated PET and computed tomography (CT), reducing quantitative accuracy. In this study, the effect of a patient-specific breathing-instructed CT protocol on the spatial alignment between CT and amplitude-based optimal respiratory-gated PET images was investigated. Methods: 18 F-fluorodeoxyglucose (FDG) PET/CT imaging was performed in 20 patients...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413601/an-evaluation-of-qualities-of-nuclear-medicine-technology-programs-and-graduates-leading-to-employability
#3
Cybil J Nielsen, Sarah Brosmer, Patrick Byrne, Gregory Jennings
Rationale: To evaluate the association between qualities of nuclear medicine technology (NMT) programs and graduates, and employability. Methods: We identified all NMT certification board applicants who passed the entry level NMT exam between 2012 and 2017. Certificants were e-mailed a survey with questions regarding graduate qualities, program qualities, and initial employment. Each quality was quantified. Age, gender, and desired employment within or outside the USA were also documented. An employability scale was created from the initial employment questions...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413600/radiation-safety-certification-a-review
#4
Cybil J Nielsen
It has become common for nuclear medicine technologists to assume the responsibilities, or even the role, of the radiation safety officer (RSO) or associate radiation safety officer (ARSO). Their responsibilities are primarily related to the radioactive materials license, but increasingly can include additional safety responsibilities within the hospital. This includes Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Fluoroscopy safety. Many technologists reading this article may be interested in sitting for the Radiation Safety advanced certification exam by the Nuclear Medicine Technology Certification Board (NMTCB)...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413599/comparison-of-radioiodine-uptake-by-gamma-camera-and-thyroid-uptake-probe-based-methodologies-and-diagnostic-radioiodine-scan-in-differentiated-thyroid-carcinoma
#5
Biju K Menon, Atanu Bhattacharjee, Sandip Basu
Aims and Objectives: The objective of the study was to make a quantitative comparison of 72-hrs neck uptake calculated by gamma camera-based and thyroid uptake probe-based methods after administration of low-dose (111-148 MBq) of 131 I capsule in thyroid carcinoma follow-up patients who have already been treated with 131 I. Methods: The study group consists of 46 patients, of whom 14 were male (average 47.5 yrs) and 32 were female (average 38 yrs). All patients already had undergone thyroidectomy followed by 131 I treatment at least once and came to the institute after 6 months for follow-up...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413598/technologist-approach-to-global-dose-optimization
#6
Pedro Fragoso Costa, Elizabeth A Bailey, Norman E Bolus, Tina M Alden, Giorgio Testanera, Luca Camoni, Christelle Terwinghe
Nuclear Medicine Technologists (NMTs) are specialized health professionals that cover a wide range of tasks from clinical routine (including image acquisition and processing, radiopharmaceutical dispensing and administration, patient care and radioprotection tasks) to leading clinical research in the field of Nuclear Medicine. As a fundamental concern in all radiation sciences applied to medicine, protection of individuals against the harmful effects of ionizing radiation must be constantly revised and applied by the professionals involved in medical exposures...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413597/in-patients-we-trust-reliability-of-self-reported-weight-and-size-in-patients-attending-a-nuclear-medicine-department
#7
Katrin S Blum, Nadine Büsch, Thomas Beyer, Ivo Rausch, Lutz S Freudenberg
Purpose: The aim of the study was to assess the reliability of self-reported weight and size of nuclear medicine patients in view of recommendation for the weight-dependent tracer application for imaging and therapy. Methods: A total of 824 patients (334m, 490f) were asked to report their weight and size prior imaging or therapy and their level of confidence. Subsequently, weight and size of each patient was measured and body mass index (BMI), body surface area (BSA) and lean body mass (LBM) were calculated...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413596/integrative-leadership-and-its-use-in-providing-excellent-patient-care-while-overcoming-hospital-challenges
#8
Julie Bolin
Effective leadership in the healthcare setting is vital for delivering effective and efficient patient care while meeting organizational and departmental challenges. Hospitals face unique obstacles relating to regulation and accreditation, process inefficiencies, aging or difficult to treat patients, allocation of resources, and patient satisfaction. This article describes the characteristics of a leader, integrative leadership in the healthcare setting, and provides suggestions to engage coworkers in solving complex healthcare problems...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413595/accreditation-and-assessment-the-basics-for-nuclear-medicine-educators
#9
Penni A Longenecker
This article presents a high-level overview of accreditation and assessment in higher education.It is designed to provide nuclear medicine technology (NMT) educators with a foundational knowledge of accreditation and assessment. This foundation will help educators understand accreditation and assessment at the college/university and program levels by discussing key terminology and exploring the concept of a culture of assessment.
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413594/encouraging-lifelong-learning-an-educator-s-perspective-on-teaching-and-learning-for-the-nuclear-medicine-technologist
#10
Isabel T Breen
The rapid influx of new technology and changing reimbursement and healthcare business models challenge nuclear medicine technology (NMT) educators to reexamine the effectiveness of traditional teaching methods. As a generation of technologists can attest, the skill sets and competencies taught today will not be the requirements of tomorrow. The question arises, "how can educators prepare students and the profession for future knowledge capacity?" The concept of lifelong learning (LLL) emerged in the 1970s as a response to the global paradigm shift from an industrial society to a knowledge society...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413593/assessing-f-18-fdg-uptake-in-the-sentinel-lymph-node-in-breast-cancer
#11
Ismet Sarikaya, Ali Sarikaya
Objective: Fluorine-18 fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) has limited value in early breast cancer. Sentinel lymph node (SLN) biopsy is the current procedure of choice to search for small metastatic deposits in the axillary lymph nodes in early breast cancer. In this retrospective study, we re-evaluated 18 F-FDG PET/CT images after locating SLN(s) on PET/CT with the help of SLN single photon emission computed tomography/computed tomography (SPECT/CT) images and assessed 18 F-FDG uptake particularly in the SLN(s)...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30413592/the-influence-of-minimal-misalignment-on-the-repeatability-of-pet-images-examined-by-the-repositioning-of-point-sources
#12
Akira Maebatake, Keishin Morita, Go Akamatsu, Yuji Tsutsui, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
Objective: We aimed to evaluate the influence of the minimal misalignment of the hot spot on the repeatability of PET images using the repositioning of point sources. Methods: Point sources with an inner-diameter of 1 mm were made with 1μL of 18 F solution. Seven point sources were placed on the x-axis in the field-of-view. For fixed position imaging, PET data were acquired for 10 min 5 times serially. For variable position imaging, PET data were acquired for 10 minutes each with the point sources placed at 0 mm, ±0...
November 9, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139889/small-cell-transformation-of-metastatic-prostate-adenocarcinoma-diagnosed-by-dual-tracer-pet-ct-68-ga-psma-and-18-f-fdg-potential-clinical-utility-in-therapeutic-decision-making-and-treatment-monitoring
#13
Rahul Vithalrao Parghane, Sandip Basu
Transformed small cell carcinoma of prostate represents a distinct tumor biology from the adenocarcinoma counterpart and penile metastasis from prostate cancer is a rare entity. Unique features of this transformation include unresponsiveness to hormonal therapy and presence of visceral metastases, which can demonstrate hypermetabolism on 18 F-FDG PET/CT. The importance of dual tracer PET/CT using 68 Ga-PSMA and 18 F-FDG is illustrated in metastatic prostatic adenocarcinoma (Gleason's score 4+3=7) with previous history of bilateral orchidectomy, chemotherapy and radiotherapy, who presented with abdominal pain and backache, dysuria and increasing serum PSA...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139888/alzheimer-s-disease-and-the-effects-it-has-on-the-patient-and-their-family
#14
Barbara J Grabher
Understanding the stressors that affect Alzheimer's disease (AD) patients, their families, and caregivers, enables us, as a society to provide the support and care both the patient and their families need to try to live a happy and healthy life despite living with the diagnosis of AD. The diagnosis of AD not only affects the patient, but it affects the entire family. This continuing education (CE) article examines the epidemic of AD in the US today and the effects it has on the patient and their family. It discusses ways that caregivers can reduce their stress while taking care of their loved ones so that they can live a happy and healthy life too; as they struggle to balance their family responsibilities with taking care of their loved one with AD...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139887/enhanced-gastric-emptying-scintigraphy-to-assess-fundic-accommodation-using-intragastric-meal-distribution-and-antral-contractility
#15
Perry Orthey, Simin Dadparvar, Henry P Parkman, Alan Maurer
Gastric emptying scintigraphy (GES) as now commonly performed measures only total gastric emptying. Intragastric meal distribution (IMD) immediately post meal ingestion (t= 0 min) (IMD0) ) can assess fundic accommodation (FA) and dynamic antral contraction scintigraphy (DACS) can assess antral motility. GOALS: 1) Incorporate IMD and DACS into GES; 2) Compare IMD0 using gastric division into anatomic proximal and distal halves vs more physiologic separation of the antrum from proximal stomach using DACS; 3) establish normal values...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139886/comparison-of-the-variability-of-suvs-normalized-by-skeletal-volume-with-that-of-suvs-normalized-by-body-weight-in-normal-18-f-fluoride-pet-ct-studies
#16
José Flávio Gomes Marin, Paulo Schiavom Duarte, José Willegaignon de Amorim de Carvalho, Heitor Naoki Sado, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Objective: to test the hypothesis that the variability of the standardized uptake values (SUVs) normalized by skeletal volume (SV) in 18 F-fluoride PET/CT (18 F-NaF) studies is lower than that of the SUVs normalized by body weight (BW). Methods: the SUVs were obtained in whole skeletal volumes of interest (wsVOIs) in 163 selected 18 F-NaF studies. These studies were performed for the investigation of bone metastases and considered normal by evaluation of PET and CT images. The SUVs were calculated using normalization by BW, by SV and without normalization (WN)...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139885/pharmacology-part-3b-less-commonly-used-interventional-medications-and-adjunctive-medications-in-general-nuclear-medicine
#17
Geoffrey M Currie
The understanding of key principles in pharmacology is essential to the clinical and research nuclear medicine practitioner. The scope of practice of the nuclear medicine technologist requires capability around the indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for interventional and adjunctive medications. This article is the companion article to the third in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139884/bilateral-orbital-soft-tissue-metastases-from-renal-neuroendocrine-tumor-successful-theranostic-application-of-68-ga-177-lu-dotatate-with-improvement-of-vision
#18
Rahul Vithalrao Parghane, Sandip Basu
Gratifying clinical response obtained in the clinical setting of bilateral orbital metastases from renal neuroendocrine tumor (NET) is reported. Methods: A 53 year-old male, diagnosed case of renal NET (MIB1 index-4%), with symptoms of skeletal and abdominal pain, proptosis and decrease in vision of left eye, was found to harbor bilateral orbital soft tissue lesions on 68 Ga-DOTATATE PET-CT and MRI in addition to widespread metastatic skeletal lesions, and metastatic lymph nodal disease. His symptoms worsened despite radiotherapy to left eye (20Gy) and long-acting octreotide therapy for 18 months, with increase in serum chromogranin A (CgA) level and was considered for 177 Lutetium(Lu)-DOTATATE peptide receptor radionuclide therapy (PRRT)...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139883/spect-ct-guided-ultrasound-for-parathyroid-adenoma-localisation-a-one-stop-approach
#19
Philip Touska, Alison Elstob, Nikhil D Rao, Arum Parthipun
Rationale: To evaluate the accuracy of one-stop (single patient attendance) SPECT-CT-guided ultrasound (US) in the localisation of parathyroid adenomata (PTA). Secondary aims included analysing the effect of multiple PTA and concurrent thyroid disease on sensitivity. Methods: Patients with hyperparathyroidism that had undergone parathyroidectomy were identified over a 5 year period. Pathological correlation with results from pre-operative sestamibi SPECT-CT followed by targeted US of the neck was performed...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139882/practical-clinical-measurement-of-radiotracer-concentration-in-blood-initial-device-concept-and-feasibility-testing
#20
Josh Knowland, Ronald Lattanze, Jesse Kingg, Steven Perrin
Kinetic analysis of PET data requires continuous measurement of radioactivity in the arterial blood throughout the acquisition time, termed the arterial input function (AIF). The AIF is used as an input to compartmental modeling, which can be a better predictor of disease progression than SUV measurements from static PET images. Current common methods of measuring blood concentrations include image-derived, population-based, and manual sampling. These all have challenges due to logistical and technological issues as well as patient burden...
August 23, 2018: Journal of Nuclear Medicine Technology
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