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Journal of Nuclear Medicine Technology

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https://www.readbyqxmd.com/read/30139889/small-cell-transformation-of-metastatic-prostate-adenocarcinoma-diagnosed-by-dual-tracer-pet-ct-68-ga-psma-and-18-f-fdg-potential-clinical-utility-in-therapeutic-decision-making-and-treatment-monitoring
#1
Rahul Vithalrao Parghane, Sandip Basu
Transformed small cell carcinoma of prostate represents a distinct tumor biology from the adenocarcinoma counterpart and penile metastasis from prostate cancer is a rare entity. Unique features of this transformation include unresponsiveness to hormonal therapy and presence of visceral metastases, which can demonstrate hypermetabolism on 18 F-FDG PET/CT. The importance of dual tracer PET/CT using 68 Ga-PSMA and 18 F-FDG is illustrated in metastatic prostatic adenocarcinoma (Gleason's score 4+3=7) with previous history of bilateral orchidectomy, chemotherapy and radiotherapy, who presented with abdominal pain and backache, dysuria and increasing serum PSA...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139888/alzheimer-s-disease-and-the-effects-it-has-on-the-patient-and-their-family
#2
Barbara J Grabher
Understanding the stressors that affect Alzheimer's disease (AD) patients, their families, and caregivers, enables us, as a society to provide the support and care both the patient and their families need to try to live a happy and healthy life despite living with the diagnosis of AD. The diagnosis of AD not only affects the patient, but it affects the entire family. This continuing education (CE) article examines the epidemic of AD in the US today and the effects it has on the patient and their family. It discusses ways that caregivers can reduce their stress while taking care of their loved ones so that they can live a happy and healthy life too; as they struggle to balance their family responsibilities with taking care of their loved one with AD...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139887/enhanced-gastric-emptying-scintigraphy-to-assess-fundic-accommodation-using-intragastric-meal-distribution-and-antral-contractility
#3
Perry Orthey, Simin Dadparvar, Henry P Parkman, Alan Maurer
Gastric emptying scintigraphy (GES) as now commonly performed measures only total gastric emptying. Intragastric meal distribution (IMD) immediately post meal ingestion (t= 0 min) (IMD0) ) can assess fundic accommodation (FA) and dynamic antral contraction scintigraphy (DACS) can assess antral motility. GOALS: 1) Incorporate IMD and DACS into GES; 2) Compare IMD0 using gastric division into anatomic proximal and distal halves vs more physiologic separation of the antrum from proximal stomach using DACS; 3) establish normal values...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139886/comparison-of-the-variability-of-suvs-normalized-by-skeletal-volume-with-that-of-suvs-normalized-by-body-weight-in-normal-18-f-fluoride-pet-ct-studies
#4
José Flávio Gomes Marin, Paulo Schiavom Duarte, José Willegaignon de Amorim de Carvalho, Heitor Naoki Sado, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Objective: to test the hypothesis that the variability of the standardized uptake values (SUVs) normalized by skeletal volume (SV) in 18 F-fluoride PET/CT (18 F-NaF) studies is lower than that of the SUVs normalized by body weight (BW). Methods: the SUVs were obtained in whole skeletal volumes of interest (wsVOIs) in 163 selected 18 F-NaF studies. These studies were performed for the investigation of bone metastases and considered normal by evaluation of PET and CT images. The SUVs were calculated using normalization by BW, by SV and without normalization (WN)...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139885/pharmacology-part-3b-less-commonly-used-interventional-medications-and-adjunctive-medications-in-general-nuclear-medicine
#5
Geoffrey M Currie
The understanding of key principles in pharmacology is essential to the clinical and research nuclear medicine practitioner. The scope of practice of the nuclear medicine technologist requires capability around the indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for interventional and adjunctive medications. This article is the companion article to the third in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139884/bilateral-orbital-soft-tissue-metastases-from-renal-neuroendocrine-tumor-successful-theranostic-application-of-68-ga-177-lu-dotatate-with-improvement-of-vision
#6
Rahul Vithalrao Parghane, Sandip Basu
Gratifying clinical response obtained in the clinical setting of bilateral orbital metastases from renal neuroendocrine tumor (NET) is reported. Methods: A 53 year-old male, diagnosed case of renal NET (MIB1 index-4%), with symptoms of skeletal and abdominal pain, proptosis and decrease in vision of left eye, was found to harbor bilateral orbital soft tissue lesions on 68 Ga-DOTATATE PET-CT and MRI in addition to widespread metastatic skeletal lesions, and metastatic lymph nodal disease. His symptoms worsened despite radiotherapy to left eye (20Gy) and long-acting octreotide therapy for 18 months, with increase in serum chromogranin A (CgA) level and was considered for 177 Lutetium(Lu)-DOTATATE peptide receptor radionuclide therapy (PRRT)...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139883/spect-ct-guided-ultrasound-for-parathyroid-adenoma-localisation-a-one-stop-approach
#7
Philip Touska, Alison Elstob, Nikhil D Rao, Arum Parthipun
Rationale: To evaluate the accuracy of one-stop (single patient attendance) SPECT-CT-guided ultrasound (US) in the localisation of parathyroid adenomata (PTA). Secondary aims included analysing the effect of multiple PTA and concurrent thyroid disease on sensitivity. Methods: Patients with hyperparathyroidism that had undergone parathyroidectomy were identified over a 5 year period. Pathological correlation with results from pre-operative sestamibi SPECT-CT followed by targeted US of the neck was performed...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139882/practical-clinical-measurement-of-radiotracer-concentration-in-blood-initial-device-concept-and-feasibility-testing
#8
Josh Knowland, Ronald Lattanze, Jesse Kingg, Steven Perrin
Kinetic analysis of PET data requires continuous measurement of radioactivity in the arterial blood throughout the acquisition time, termed the arterial input function (AIF). The AIF is used as an input to compartmental modeling, which can be a better predictor of disease progression than SUV measurements from static PET images. Current common methods of measuring blood concentrations include image-derived, population-based, and manual sampling. These all have challenges due to logistical and technological issues as well as patient burden...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30139881/optimization-of-parameters-for-quantitative-analysis-of-123-i-ioflupane-spect-images-for-monitoring-of-progression-of-parkinson-s-disease
#9
Phillip Hsin Kuo, Naghmehossadat Eshghi, Sule Tinaz, Hal Blumenfeld, Elan D Louis, George Zubal
Objectives: Quantitative assessment of dopamine transporter (DAT) imaging can aid in diagnosing Parkinson's disease (PD) and assessing disease progression in the context of therapeutic trials. Previously, the software program SBRquant was applied to 123 I-ioflupane SPECT images acquired on healthy controls and subjects with PD. Earlier work on optimization of the parameters for differentiating between controls and subjects with dopaminergic deficits is extended here for maximizing change measurements associated with disease progression on longitudinally acquired scans...
August 23, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076254/effects-of-web-based-information-on-patient-satisfaction-and-image-quality-in-patients-undergoing-an-18-f-fdg-pet-ct-examination-a-randomised-controlled-trial
#10
Camilla Andersson, Carlos Trampal Pulido, Håkan Ahlström, Birgitta Johansson
The aim was to investigate the effect of web-based patient information on patients' satisfaction with care during an 18 F-FDG PET/CT examination, their knowledge about the examination and the image quality, compared with standard care, and to explore the usage of and satisfaction with web-based information. Methods: One hundred-forty-eight patients were recruited between October 2015 and December 2016 and randomly assigned to Standard Care (SC) or an Intervention Group (IG). SC received information about the 18 F-FDG PET/CT examination according to standard care and IG also received access to web-based information about the examination...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076253/current-status-of-f-18-fdg-pet-brain-imaging-in-patients-with-dementia
#11
Ismet Sarikaya, Ali Sarikaya, Abdelhamid H Elgazzar
Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) brain imaging is commonly used in the early detection and differential diagnosis of various subtypes of dementias. F-18 FDG PET images are mainly evaluated visually and semi-quantitative (SQ) analysis programs are also commonly used in many centers. However, visual and SQ analysis carry certain limitations. Visual assessment is subjective and dependent on expertise. Commercially available SQ analysis programs have certain limitations such as suboptimal selection of brain areas or erroneous uptake normalization procedure which may provide inaccurate results and physicians reporting SQ results should be aware of these...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076252/protocols-for-harmonized-quantification-and-noise-reduction-in-low-dose-oncological-18-f-fdg-pet-ct-imaging
#12
Marcos A D Machado, Vinícius O Menezes, Mauro Namías, Naiara S Vieira, Cleiton C Queiroz, Roberta Matheoud, Adam M Alessio, Mércia L Oliveira
Purpose: Oncological 18 F-FDG PET/CT acquisition and reconstruction protocols need to be optimized for both quantitative and detection tasks. To date, most studies have focused on either quantification or noise, leading to quantitative harmonization guidelines or appropriate noise levels. We developed and evaluated protocols that provide harmonized quantitation with optimal amount of noise as a function of acquisition parameters and body mass. Methods: Multiple image acquisitions ( N = 17) of the IEC/NEMA PET image quality phantom were performed with variable counting statistics...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076251/practical-consideration-for-integrating-pet-ct-in-radiation-therapy-planning-for-patient-care
#13
Shelley N Acuff, Anetia S Jackson, Rathan M Subramaniam, Dustin R Osborne
Over the past 20 years, PET/CT has had many technological and developmental advancements for patient care. PET/CT has evolved from solely used as a diagnosis and staging tool to now having an impact on treating cancer through a collaboration with radiation oncology. There are multiple considerations when integrating PET/CT into radiation therapy planning such as PET/CT center needs, the types of scans to offer, workflow considerations between the two centers, PET/CT center growth and demand on schedules, and the impact PET/CT will have on radiation treatment planning...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076250/supporting-the-quality-of-measurement-and-evaluation-in-education
#14
Donna Mason, William Wentling, Nadine Englert, Lynn George, Holly Hampe, Susan Hellier, Judith Kaufmann, Lisa Locasto, Donna McDermott
The impetus for the development of a measurement and evaluation committee for Robert Morris University, School of Nursing and Health Sciences (SNHS) was to foster faculty and administration commitment in enhancing the quality of measurement and evaluation processes. Many of the SNHS faculty members had experienced incidents of academic inconsistencies with student examination protocols. The Measurement and Evaluation Team (MET) was charged to define the goals for faculty to utilize evidence-based assessment and evaluation strategies that are appropriate for the learner and learning goals, support utilization of evaluation data to measure the achievement of designated outcomes, and promote curricular excellence through the use of assessment and evaluation data and policies to enhance the teaching/ learning process...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076249/fdg-avid-internal-mammary-lymphadenopathy-and-implant-rupture-in-pet-ct-unveiling-clinically-unsuspected-silicone-granuloma-in-treated-breast-cancer
#15
Fathima Fijula Palot Manzil, Pradeep Bhambhvani
Fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake in enlarged lymph nodes is always suspicious, especially in cancer patients. We report a case of hypermetabolic internal mammary lymphadenopathy in a breast cancer patient who was previously treated with bilateral mastectomy and implants. The abnormal nodal uptake turned out to be due to foreign body induced inflammation, confirmed on histopathology. Vigilant PET interpretation is required in breast cancer patients with evidence of breast implant rupture.
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076248/pharmacology-part-3a-interventional-medications-in-renal-and-biliary-imaging
#16
Geoffrey M Currie
Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners. Indeed, the scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is the third in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076247/pilot-study-regional-changes-in-brain-18-f-fdg-uptake-after-prophylactic-cranial-irradiation-and-chemotherapy-in-small-cell-lung-cancer-may-reflect-functional-changes
#17
Naghmehossadat Eshghi, Linda Garland, Gagandeep Choudhary, Charles C Hsu, Anna Eshghi, James Han, Russell J Hamilton, Elizabeth Krupinski, Phillip Hsin Kuo
Objective: Chemotherapy followed by prophylactic cranial irradiation (PCI) is associated with increased survival in patients with small cell lung cancer (SCLC) but is associated with fatigue and cognitive impairment. This retrospective study evaluated regional differences in fluorodeoxyglucose (18 F-FDG) uptake of the brain before and after PCI. The null hypothesis was that direct toxic effects on the brain from PCI and chemotherapy are symmetric, thus asymmetric deviations may reflect functional changes due to therapy...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076246/validation-of-the-semi-automatic-quantification-of-18-f-fluoride-pet-ct-whole-body-skeletal-tumor-burden
#18
Ana Emília Teixeira Brito, Felipe Mourato, Allan Santos, Camila Mosci, Celso Ramos, Elba Etchebehere
PURPOSE: To validate a semi-automatic quantification of the skeletal tumor burden on 18 F-Fluoride PET/CT by using manual quantification as a reference. METHODS: We quantified 51 18 F-Fluoride PET/CT exams performed on female breast cancer patients. Clinical information (age, time of disease, presence of visceral metastases, and time to death, progression or bone event) was recorded. The total volume of fluoride-avid skeletal metastases (FTV10) and the total activity of 18 F-Fluoride-avid metastases (TLF10) were calculated manually (mTLF10 and mFTV10, respectively) and semi-automatically (saTLF10 and saFTV10, respectively)...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076244/establishing-a-radiation-safety-credential-for-nuclear-medicine-technologists
#19
Frederic Fahey, Briana Sexton-Stallone, Jon Shepard
A number of nuclear medicine technologists have specific responsibilities and considerable experience in radiation safety. In many instances, the technologist's level of knowledge regarding radiation safety goes beyond what is typically expected of them. The Nuclear Medicine Technology Certification Board (NMTCB) performed a needs assessment for a radiation safety credential for nuclear medicine technologists. The assessment included the delivery and evaluation of 2 surveys which both indicated that there was interest among nuclear medicine technologists for a specific credential regarding radiation safety...
August 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/30076243/hepatobiliary-iminodiacetic-acid-scanning-detects-previously-unknown-hepatic-metastases-from-colonic-adenocarcinoma
#20
Jonathan Chapman, Edward Sutherland, Jane Palka
A case of previously unknown metastatic colorectal adenocarcinoma presents as focal photopenia on hepatobiliary iminidiacetic acid scintigraphy (HIDA scan). Differential diagnosis of focal photopenia and heterogenous hepatic radiotracer uptake on hepatobiliary scintigraphy is reviewed.
August 3, 2018: Journal of Nuclear Medicine Technology
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