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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/29044701/malignant-pecoma
#1
Daniela Haiges, Philipp Kurz, Helmut Laaff, Frank Meiss, Heinz Kutzner, Kristin Technau-Hafsi
We report a metastasizing PEComa in a pregnant 41-year-old female who had initially presented at her dermatologist during the first trimester of pregnancy with a newly developed indolent, slowly growing dermatofibroma-like tumor on the back of the left thigh. During pregnancy and after parturition, the lesion considerably progressed in size (Fig.1); tumor excision was performed 14 months after initial presentation.
October 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29028127/pure-mucinous-colloid-adenocarcinoma-of-the-conjunctiva
#2
Valentina Logunova, Olayemi Sokumbi
Mucinous carcinomas of the periorbital area are very rare malignant tumors and can be primary or secondary to metastasis. Primary mucinous carcinomas of the eyelid include, most commonly, primary cutaneous mucinous carcinoma with endocrine mucin-producing sweat gland carcinoma being a remote second.[1,2,3,4] To our knowledge, primary mucinous carcinomas of conjunctiva or lacrimal gland elements have not been described in the literature.[5,6] Metastatic carcinoma from visceral sites should also be considered in the differential diagnosis...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29028126/leukocytoclastic-vasculitis-presenting-in-association-with-coxiella-burnetii-q-fever-a-case-report
#3
Stephen S Koh, Aldon Li, David S Cassarino
Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41 year old male complaining of body aches, fevers, nausea, malaise, bilateral knee pain, and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Workup revealed positive serologic testing for C burnetii and skin biopsy of the rash revealed leukocytoclastic vasculitis...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29028122/atypical-alk-positive-spitz-tumors-with-9p21-homozygous-deletion-report-of-two-cases-and-review-of-the-literature
#4
Andrew J Rand, Wendy L Flejter, Christopher A Dowling, Linda M Brooke, Genevieve M Boland, Daniela Kroshinsky, Isaac R Rosenblum, Marier Hernandez-Perez, Julie D R Reimann
ALK rearrangements occur in up to 10% of spitzoid melanocytic neoplasms. No reported cases have shown homozygous deletion of 9p21 (CDKN2A) or gains of 6p25 (RREB1) or 11q13 (CCND1), which have been associated with aggressive clinical behavior. Here we report two unique cases. Case 1 occurred in a 9-year-old male with a 14-mm nodule on the anterior left thigh. Biopsy revealed an ALK-positive Spitz tumor containing an irregular nodule of densely packed melanocytes with increased mitoses and loss of p16 immunoreactivity...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29028121/lupus-like-cutaneous-reaction-following-pembrolizumab-an-immune-related-adverse-event-associated-with-anti-pd-1-therapy
#5
Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y Chu
PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata, and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29023944/reconsidering-the-h-e-stain-as-the-gold-standard-in-assessing-the-depth-of-burn-wounds
#6
Arlene S Rosenberg
While histological examination is considered by most as the gold standard for burn depth assessment, it has no practical use in the clinical setting. It has, however, been used in the research setting, as a mean for evaluating emerging techniques of depth measurement. Due to the limitations of the H&E stain, other stains have also been explored, such as lactate dehydrogenase (LDH), as presented in this issue, in "Improving the Histologic Characterization of Burn Depth." As the determination of burn depth is not a typical subject in dermatopathology, a summary of selected techniques and the possible role for the LDH stain in future research, is described herein...
October 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29023912/basophils-are-recruited-and-localized-at-the-site-of-tick-bites-in-humans
#7
Ryoko Kimura, Kazunari Sugita, Ayako Ito, Hiroyuki Goto, Osamu Yamamoto
No abstract text is available yet for this article.
October 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29023848/folliculocystic-and-collagen-hamartoma-of-tuberous-sclerosis-a-new-case-in-a-female-patient-and-review-of-literature
#8
Laura Kaplan, Viktoryia Kazlouskaya, Rex Ugorji, Edward Heilman, Daniel Siegel, Sharon A Glick
Folliculocystic and collagen hamartoma (FCCH) of tuberous sclerosis is a rare entity described in 2012 by Torrelo et al with only eight cases described predominantly in males. It presents since birth or early infancy and in the majority of cases is associated with tuberous sclerosis. The hamartoma presents as an exophytic plaque and has distinctive histopathological features including hair follicles, intact or ruptured epidermal cysts, and an increased number of collagen fibers extending to the subcutaneous tissue...
October 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29023827/tnf%C3%AE-and-il-17a-are-differentially-expressed-in-psoriasis-like-vs-eczema-like-drug-reactions-to-tnf%C3%AE-antagonists
#9
C Deubelbeiss, A G A Kolios, L E French, N Yawalkar, W Kempf, K Kerl, B Meier, F Anzengruber, A A Navarini
BACKGROUND: Tumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema-like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. The exact pathophysiology is as yet unknown. METHODS: 33 patients (19 female, average age 52 years) who had a cutaneous reaction to infliximab, adalimumab or etanercept were included...
October 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28990684/a-new-scenario-in-the-immunohistochemical-diagnosis-of-cutaneous-leishmaniasis
#10
Angel Fernandez-Flores
No abstract text is available yet for this article.
October 9, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28984999/direct-immunofluorescence-testing-in-vasculitis-a-single-institution-experience-with-henoch-sch%C3%A3-nlein-purpura
#11
Patrick Feasel, Steven D Billings, Wilma F Bergfeld, Melissa P Piliang, Anthony P Fernandez, Jennifer S Ko
BACKGROUND: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results. METHODS: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of HSP. Peri/intravascular IgA was considered "positive," other reactants "non-specific," and no immunoreactivity "negative...
October 6, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28981153/pleomorphic-fibroma-of-the-skin-with-mdm2-immunoreactivity-a-potential-diagnostic-pitfall
#12
Mehrnoosh Tashakori, Jason Pimentel, Brooke E Howitt, Jessica Sanchez, Susan Michalowski, Dhananjay Chitale, Adrian H Ormsby, Sean R Williamson
Pleomorphic fibroma is a rare benign cutaneous neoplasm characterized by spindle-shaped cells and multinucleated giant cells scattered throughout collagenous stroma. These morphologic features can lead to diagnostic confusion, including atypical lipomatous tumor as one consideration. In contrast to atypical lipomatous tumor, previous studies have found pleomorphic fibroma to be negative for MDM2 immunohistochemical staining and MDM2 gene amplification. Here, we present a case of pleomorphic fibroma of skin with nuclear MDM2 immunoreactivity in the absence of MDM2 gene amplification, underscoring the superiority of fluorescence in situ hybridization as a diagnostic test in this differential diagnosis...
October 5, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28981149/an-interesting-case-of-pyoderma-gangrenosum-with-immature-hystiocytoid-neutrophils
#13
Catherine Besner Morin, Benoit Côté, Annie Belisle
We present a unique case of a 36-year-old male who developed more than twenty Pyoderma gangrenosum ulcers demonstrating on histopathology a dense inflammatory infiltrate composed of histiocytoid mononuclear immature cells with a strong positivity for myeloperoxidase and Leder stain, suggesting a myeloid lineage in the absence of a concomitant myeloproliferative disorder. Histiocytoid Sweet syndrome is now recognized as a histological subtype of Sweet syndrome. Although Pyoderma gangrenosum and Sweet syndrome belong to the spectrum of neutrophilic diseases, to the best of our knowledge, this is the first case of a "Histiocytoid Pyoderma gangrenosum" encompassing immature granulocytes in the absence of leukemia cutis...
October 5, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28960456/primary-large-cell-neuroendocrine-carcinoma-of-the-skin-an-under-recognized-entity-and-a-mimic-of-metastatic-disease
#14
Ian Marie Lano, Daniel Rayson, Thomas Arnason, Noreen M G Walsh
Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62 year old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent...
September 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28960405/expression-of-connexin43-cx43-in-the-human-hair-follicle-emphasis-on-the-cx43-protein-levels-in-the-bulge-and-through-the-keratinization-process
#15
A Fernandez-Flores, A Varela-Vazquez, M D Mayan, E Fonseca
INTRODUCTION: Gap junctions form communication compartments between cells. These channels assemble from connexin (Cx) subunits. OBJECTIVE: To investigate the immunoexpression of Cx43 in adult human hair follicles. MATERIALS AND METHODS: Cases were retrospectively obtained from our archives. RESULTS: We identified immunoexpression of Cx43 in the matrix, the papilla, the outer root sheath, the bulge, the medulla, the cortex, the shaft, and the secretory part of the sebaceous gland...
September 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28940544/chronic-granulomatous-dermatitis-induced-by-talimogene-laherparepvec-therapy-of-melanoma-metastases
#16
Ashlyn S Everett, Peter G Pavlidakey, Carlo M Contreras, Jennifer F De Los Santos, Ju Y Kim, Svetlana B McKee, Howard L Kaufman, Robert M Conry
Talimogene laherparepvec is the first oncolytic viral immunotherapy approved by the FDA, for advanced melanoma consisting of genetically modified herpes simplex type 1 virus which selectively replicates causing tumor lysis, expressing GM-CSF and activating dendritic cells. Intratumoral injection of TVEC produces objective response in 41% of stage IIB-IV M1a melanoma. However, clinical response assessments can be problematic due to immune-related inflammation at established tumor sites. Herein, we report 5 cases of granulomatous dermatitis developing at sites of TVEC injection associated with pathologic complete response in 4 of 5 patients...
September 22, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28914958/assessment-of-histopathological-features-of-maculopapular-viral-exanthem-and-drug-induced-exanthem
#17
Sanjay Singh, Sujay Khandpur, Sudheer Arava, Ramashankar Rath, M Ramam, Manoj Singh, Vinod K Sharma, S K Kabra
Maculopapular exanthem (MPE) is defined as a skin eruption consisting of macules and papules which does not form a scale. When associated with oral lesions, the term exanthem with 'enanthem' term is employed (1). Viral infection and drug reaction are the commonest causes of exanthem.
September 15, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28914451/pilomatrix-carcinoma-a-10-year-review-of-the-literature
#18
REVIEW
Christopher Jones, Mark Twoon, Weiguang Ho, Mark Portelli, Bernard Robertson, William Anderson
Pilomatrixoma, also known as calcifying epithelioma of Malherbe, is a superficial benign skin tumour arising from hair follicle matrix cells (1,2) usually located in the head or neck region (1). It was first described in 1880 by Malherbe and Chenantais as a calcified epithelioma of sebaceous origin. In 1961, Forbis and Helwig proposed the term pilomatrixoma after establishing that the lesion actually originated from the outer root sheath cell of hair follicles (3-5).
September 15, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28906023/immunophenotypic-and-molecular-comparison-between-allogeneic-and-autologous-graft-vs-host-disease-of-the-skin-a-retrospective-study-using-immunohistochemical-and-proteomics-methods
#19
Julia S Lehman, Shahrukh K Hashmi, Hillard M Lazarus, Rokea A El-Azhary, Lawrence E Gibson, William J Hogan, Mark R Litzow, Mrinal S Patnaik, Francis Buadi, Martha Q Lacy, Surendra Dasari, Patrick Vanderboom, Alexander Meves
No abstract text is available yet for this article.
September 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28901563/analysis-of-serum-levels-and-cutaneous-expression-of-lipoprotein-a-in-38-patients-with-livedoid-vasculopathy
#20
Danielle P G S Espinel, Thais B Di Giacomo, Thais P Pincelli, Naiura V Pereira, Miriam N Sotto, Robert S Kirsner, Paulo R Criado
BACKGROUND: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. OBJECTIVES: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV...
September 13, 2017: Journal of Cutaneous Pathology
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