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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/28815668/primary-low-grade-neuroendocrine-carcinoma-of-the-skin-an-exceedingly-rare-entity
#1
Tiffany Y Chen, Annie O Morrison, Joe Susa, Clay J Cockerell
Low-grade neuroendocrine tumors (NET), also known as carcinoid tumor, commonly arise from the gastrointestinal and pulmonary tracts, but rarely occur in the skin. Cutaneous NET typically occurs as metastases or high grade primary lesions, called Merkel cell carcinoma. In the few cases described in literature, primary low-grade neuroendocrine carcinomas of the skin (LGNECS) are usually indolent cutaneous nodules, presenting on the head and trunk of elderly patients. LGNECS tumors are histologically similar to its counterparts arising in other anatomic locations...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28815656/multiple-progressive-annular-telangiectasias-a-clinicopathological-variant-of-cutaneous-collagenous-vasculopathy
#2
Pablo García-Martínez, Ignacio Gomez-Martin, Josep Lloreta, Ramon M Pujol
Telangiectasias are the clinical manifestation of diverse processes affecting blood vessels. Herein we report the case of a 60-year-old man presenting long-standing asymptomatic annular telangiectatic lesions with whitish centers. The histopathologic examination revealed thickened blood dermal vessel walls in the superficial dermis showing reduplication of the basement membrane resembling cutaneous collagenous vasculopathy (CCV). We suggest that this atypical clinicopathological presentation may represent either a localized annular variant of CCV or a previously unreported clinical form of multiple cutaneous telangiectasias...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28802002/congenital-neurocristic-cutaneous-hamartoma-with-poliosis-a-case-report
#3
Lauren M Wilson, Knox J Beasley, Timothy C Sorrells, Viviana V Johnson
Neurocristic Cutaneous Hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. 1 2 We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of two punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively with S-100 and the stroma showed a prominent CD34 stain...
August 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28800180/epithelioid-malignant-mesothelioma-metastatic-to-the-skin-a-case-report-and-review-of-the-literature
#4
Rachel Elizabeth Ward, Stefanie Ann Ali, Matthew Kuhar
Mesothelioma is a rare form of cancer arising from a monolayer of mesothelial cells that form the lining of the internal body cavities and organs, with the vast majority of cases arising from the pleura (65-80%), less commonly from the peritoneum (10-30%), and rarely from the pericardium and tunica vaginalis testis (1-2%).
August 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28800143/immunohistochemistry-reveals-an-increased-proportion-of-myc-positive-cells-in-subcutaneous-panniculitis-like-t-cell-lymphoma-compared-with-lupus-panniculitis
#5
Sebastian Fernandez-Pol, Danielle De Stefano, Jinah Kim
BACKGROUND: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a malignant primary cutaneous T-cell lymphoma that shares significant clinical, histopathologic, and immunophenotypic overlap with lupus erythematosus panniculitis (LEP). METHODS: We performed immunohistochemistry for the MYC oncoprotein on 23 cases of SPTCL (one CD8 negative) and 12 cases of LEP to evaluate if there are quantitative or qualitative differences in protein expression of this marker in these entities...
August 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796396/development-of-ret-mutant-cutaneous-angiosarcoma-during-braf-inhibitor-therapy
#6
Julia Dai, Christian A Kunder, Emily Y Chu, Edward Chan, Christine L Egan, Roberto A Novoa
Treatment with BRAF inhibitors may lead to paradoxical mitogen-activated protein kinase (MAPK) pathway activation and accelerated tumorigenesis in cells with preexisting oncogenic hits. This phenomenon manifests clinically in the development of squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) in patients treated with BRAF inhibitors. Cases of extracutaneous malignancies associated with BRAF inhibitors have also been reported. We present a case of a patient who developed a cutaneous angiosarcoma six months after initiation of vemurafenib therapy...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796379/review-of-the-current-medical-literature-and-assessment-of-current-utilization-patterns-regarding-human-papillomavirus-in-situ-hybridization-and-immunohistochemistry-in-dermatopathology
#7
REVIEW
Brandon R Litzner, Jason B Lee, Claudia I Vidal
Human papillomaviruses have been implicated in many cutaneous diseases. Practicing dermatopathologists often consider using immunohistochemistry and in situ hybridization to help clarify the histologic diagnosis, particularly in cases with borderline or non-diagnostic features. We reviewed the current evidence behind the use of these two techniques in dermatopathology. We identified only two studies utilizing the currently available immunohistochemical antibodies. We found more evidence regarding the use of in situ hybridization; however, the majority of this evidence focuses on diagnosing condylomas and other lesions of the genital skin...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796362/primary-cutaneous-acral-cd8-positive-t-cell-lymphoma-with-extra-cutaneous-involvement-a-long-standing-case-with-an-unexpected-progression
#8
Alberti-Violetti S, Fanoni D, Provasi M, Corti L, Venegoni L, Berti E
Primary cutaneous acral CD8+ T-cell lymphoma (acral CD8+ TCL) is a new provisional entity characterized by acral skin lesions and an indolent course. We describe an extraordinary case characterized by relapsed nodules with CD8+ cytotoxic infiltrates on the left ear. After 35 years, the skin lesions spread to other acral sites, and a mass with the same histological features as the other skin lesions appeared on the nose. Multiple courses of chemotherapy led to stable disease. Histological examinations carried out at different times showed the gradual transformation of the neoplastic cells with an increased proliferation index...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796338/benign-and-malignant-hybrid-adnexal-tumors-in-a-patient-with-epidermodysplasia-verruciformis
#9
Jonathan Ho, Sarah A Kam, Ali Al-Haseni, Alina Markova, Debjani Sahni, Christina Lam, Lynne J Goldberg, Jag Bhawan
Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by overgrowth of flat warts, pityriasis versicolor-like lesions and an increased propensity for developing cutaneous squamous cell carcinomas due to abnormal susceptibility to infection with beta-human papilloma viruses. Adnexal tumors are not typically associated with EV. Here we report a spectrum of hybrid adnexal tumors with divergent eccrine and folliculosebaceous differentiation, and cytologic features ranging from benign to frankly atypical, in a patient with inherited EV...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796320/congenital-cutaneous-lymphadenoma
#10
Angel Fernandez-Flores, Ina Nicklaus-Wollenteit, Dharshini Sathishkumar, Vicky Diba, Bruce Richard, Richard Carr, Celia Moss, Anita Nagy, Malobi Ogboli, Isabel Colmenero
Cutaneous lymphadenoma is an uncommon benign neoplasm often considered to be an adamantinoid variant of trichoblastoma. Lesions present in both sexes, between 14 and 87 years of age, and are mainly located on the head and neck. Cases in children are rare and there is only one previous case of a congenital lymphadenoma. An 8-year-old Asian girl presented with a congenital lesion on her forehead comprising four pink papules, the largest 5 mm in diameter. Microscopy revealed a well circumscribed tumor within the dermis and subcutis comprising well demarcated epithelial lobules of basaloid and clear cells with subtle peripheral palisading, growing in a collagenous stroma but lacking retraction artefact...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28796294/feasibility-study-in-teledermatopathology-an-examination-of-the-histopathologic-features-of-mycosis-fungoides-and-spongiotic-dermatitis
#11
Raymond M Fertig, Sudeep Gaudi, Jessica Cervantes, Austin Maddy, Omar Sangueza, John Vu, Jonhan Ho, Drazen M Jukic
BACKGROUND: Digital pathology offers numerous advantages, allowing remote information sharing using whole slide imaging (WSI) to digitize an entire glass slide at high resolution, creating a digital slide. METHODS: In this study, we examine the concordance in diagnoses made on 40 digital slides (DS) versus traditional glass slides (GS) in differentiating between spongiotic dermatitis (SD) and patch/plaque-stage mycosis fungoides (MF). RESULTS: Greater interobserver concordance rate in final diagnosis of SD vs MF was observed with the utilization of DS (86...
August 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28766737/cd117-expression-in-adenosquamous-carcinoma
#12
Gauri Panse, Jennifer M McNiff, Christine J Ko
No abstract text is available yet for this article.
August 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28753253/clear-cell-atypical-fibroxanthoma-an-unusual-case-in-an-unusual-place
#13
Zachary Goldstein, George Sarantopoulos, Chandra Smart
Atypical fibroxanthoma represents a low-grade sarcoma considered by some to be a superficial form of undifferentiated pleomorphic sarcoma.(1,2) It usually presents in the elderly population on sun-damaged areas of the head and neck regions as a dome-shaped nodule.(1,3) The clinical differential includes squamous cell carcinoma, among other skin malignancies.
July 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28753235/study-on-the-organization-of-cellular-elements-in-the-granulomatous-lesion-caused-by-chromoblastomycosis
#14
Renan Minotto, Maria Isabel Albano Edelweiss, Maria Lúcia Scroferneker
BACKGROUND: Chromoblastomycosis is a deep fungal infection characterized by a complex cellular granuloma. The aim of this study was to analyze the arrangement of cells responsible for the granuloma configuration of this disease by semiquantification of the cellular components of chromoblastomycosis skin biopsies. METHODS: The cells of cutaneous biopsies slides from 100 patients with untreated chromoblastomycosis were stained with hematoxylin-eosin and the granuloma cells were evaluated by microscopic examination of the elements of each granuloma and semiquantified the number of cells through its expressivity in crosses and the histopathological variables...
July 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28753231/pd-1-inhibitor-associated-lichenoid-inflammation-with-incidental-suprabasilar-acantholysis-or-vesiculation-report-of-four-cases
#15
Shaun Chou, Cathy Zhao, Shelley Ji Eun Hwang, Pablo Fernandez-Penas
BACKGROUND: Immune checkpoint agents targeting Programmed cell death-1 protein (PD1) or Cytotoxic T-Lymphocyte Associated Protein-4 (CTLA-4) receptors are increasingly utilised in treatment of advanced malignancies. However, these immunotherapies are commonly associated with idiosyncratic cutaneous adverse reactions. Thus, recognition and awareness of these reactions are necessary. METHODS: We reviewed the skin biopsies of all patients on anti-PD1 therapy with or without ipilimumab who developed lichenoid inflammation and included those with microscopic suprabasal or intraepidermal clefts...
July 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28749588/primary-cutaneous-cd4-positive-small-medium-sized-pleomorphic-t-cell-lymphoproliferative-disorder-report-of-a-case-and-review-of-the-literature
#16
Brett H Keeling, Alde Carlo P Gavino, Joan Admirand, Anthony C Soldano
Primary cutaneous small/medium-sized T-cell lymphoma (PCSM-TCL), which was included in the WHO-EORTC classification for cutaneous lymphomas as a provisional entity in 2008, has recently been reclassified as a lymphoproliferative disorder (PCSM-TCLPD) due to its indolent behavior and uncertain malignant potential. Treatment with local therapies is usually curative, though there have been reports of aggressive, systemic disease. This spectrum of disease behavior evokes the consideration that this entity may actually be multiple diseases with a shared clinicopathologic features rather than a singular disease process with a variety of behaviors...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28749576/review-of-the-current-medical-literature-and-assessment-of-current-utilization-patterns-regarding-mismatch-repair-protein-immunohistochemistry-in-cutaneous-muir-torre-syndrome-associated-neoplasms
#17
REVIEW
Jason B Lee, Brandon R Litzner, Claudia I Vidal
Muir-Torre syndrome is a clinical variant of Lynch syndrome defined by the synchronous or metachronous occurrence of at least one sebaceous neoplasm and at least one Lynch syndrome-related internal cancer. Although screening guidelines for patients with colorectal carcinomas have been established, screening guidelines for cutaneous Muir-Torre associated neoplasms are not currently available. As such, we reviewed the current evidence for the use of MLH1, MSH2, MSH6, and PMS2 immunohistochemistry when cutaneous Muir-Torre associated neoplasms are encountered...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28749546/familial-progressive-hyperpigmentation-a-family-resurvey-and-ultrastructural-skin-investigation
#18
Tingmei Wang, Hongwen Li, Yingying Dong, Man Hu, Qiuyun She, Yunhua Deng
Familial progressive hyperpigmentation (FPH) is an autosomal dominant genodermatosis characterized by hyperpigmented patches that increase in size and number with age. Since its initial description in an African-American family in 1971, only a few cases of FPH have been documented. A three-generation family with FPH in central China has also been reported. Here, we resurveyed that Chinese FPH family for a few unusual features including delayed age of onset and non-involvement of ocular and oral mucosae. Electron microscopic examination of skin from the proband of the family showed that there were more melanosomes in lesional keratinocytes than in perilesional keratinocytes...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28741724/quantitative-comparison-of-the-histological-subtypes-of-seborrheic-keratosis-using-computer-aided-image-analysis
#19
LETTER
Bo Ri Kim, Je Byeong Chae, Chong Won Choi, Sang Woong Youn
No abstract text is available yet for this article.
July 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28708295/cd13-is-a-marker-for-onychofibroblasts-within-nail-matrix-onychodermis-comparison-of-its-expression-patterns-in-the-nail-unit-and-in-the-hair-follicle
#20
Ji-Hye Park, Dong-Youn Lee, Kee-Taek Jang, Sang-Yun Ha, Ghee Young Kwon, Kyung-Hoon Lee, Jong Sup Shim, Eun Ji Kwon
BACKGROUND: We previously demonstrated the presence of onychodermis, a specialized mesenchymal cell population beneath the the nail matrix and proximal nail bed demonstrating CD10 expression. We hypothesize that the onychodermis could be the nail analog of the follicular dermal papilla, which is known to express CD13. We compare CD13 expression patterns between specialized mesenchymes of nail and hair, and compare these findings with CD10 expression patterns. METHODS: CD10 and CD13 immunohistochemisty was performed on polydactyly and adult cadaveric nail units, and on hair follicles in scalp nevus sebaceus excision specimens...
July 14, 2017: Journal of Cutaneous Pathology
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