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Journal of Cutaneous Pathology

Jaroslaw Jakub Jedrych, Sekhar Duraisamy, Arivarasan Karunamurthy
Aneurysmal fibrous histiocytoma (FH) is an uncommon variant of cutaneous benign fibrous histiocytoma/dermatofibroma1 typically presenting as a solitary, pigmented, up to several centimeters in size nodule on extremities or trunk of middle-aged adults.1,2 Some cases may be clinically concerning for melanoma or vascular neoplasia.1 The local recurrence rate is ~20%, if incompletely excised.1 This article is protected by copyright. All rights reserved.
August 10, 2018: Journal of Cutaneous Pathology
Jayson Miedema, Shane R Starr, May P Chan
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare entity with initial descriptions in the mid 1990's.1 It typically affects elderly patients with a slight male predominance (M:F ratio 2-3:1).2,3 Clinically, BPDCN is characterized by abrupt onset of rapidly progressive nodules or ecchymotic plaques with concurrent or subsequent involvement of the bone marrow and peripheral blood.3 Prognosis is dismal.2 Histopathologically, the neoplastic infiltrate is composed of monomorphous medium-sized to large cells expressing CD4, CD56, CD123, and TCL1...
August 10, 2018: Journal of Cutaneous Pathology
Preetha D Kamath, Jennifer L Abrahams, Jeong Hee Cho-Vega
Human T-cell lymphotropic virus-1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of CD4+ T-lymphocytes. This virus is endemic to the Caribbean, Japan, and regions of South America and Africa.[1] In Miami/ South Florida, whose population is enriched with immigrants from HTLV-1 endemic areas, we have identified multiple cases of ATLL. [2] This article is protected by copyright. All rights reserved.
August 9, 2018: Journal of Cutaneous Pathology
S Kaul, A Singal, C Grover, S Sharma
BACKGROUND: Nail psoriasis can be a diagnostic dilemma as there are several close clinical mimickers, including onychomycosis, lichen planus, and even squamous cell carcinoma. In view of differing treatment and prognostic implications, it is important to make an accurate diagnosis, especially in cases with isolated nail involvement. METHODS: Sixty consecutive patients with nail changes suggestive of psoriasis were included. A nail punch biopsy was done and histopathological features were recorded for each case and percentage positivity of each individual feature was calculated...
August 2, 2018: Journal of Cutaneous Pathology
Aria Shakeri, Benjamin H Kaffenberger, Alejandro A Gru
A female in her 60s, with a past medical history of diffuse large B cell lymphoma with cutaneous involvement on the left thigh, underwent 6 cycles of R-EPOCH (rituximab, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) chemotherapy. Restaging computed tomography scans after the chemotherapy completion demonstrated stable chest masses but enlargement of right shoulder and scapular lesions. However, positron emission tomography-computed tomography (PET/CT) showed decrease in fluorodeoxyglucose (FDG) avidity and further confirmed partial metabolic response...
August 2, 2018: Journal of Cutaneous Pathology
Caroline Maris Takatu, Luisa Juliato Tinoco, Felipe Ribeiro Ferreira, Rodrigo José de Oliveira, Felipe Hada Sanders, Mírian Nacagami Sotto, Marcello Menta Simonsen Nico
A 75 year-old Brazilian female patient was admitted to the neurosurgery ward for an elective replacement of a ventriculoperitoneal (VP) subcutaneous shunt that had been implanted four years previously for the treatment of a subarachnoid hemorrhage. Dermatological consultation was requested after discovery of cutaneous lesions overlying the shunt catheter along its tract. This article is protected by copyright. All rights reserved.
July 27, 2018: Journal of Cutaneous Pathology
Thomas H Long, Michi M Shinohara, Zsolt B Argenyi, John A Thompson, Jennifer M Gardner
Talimogene laherparepvec (T-VEC) is a novel intralesional oncolytic genetically modified herpes simplex virus type 1 vector for the treatment of unresectable cutaneous, subcutaneous, and nodal melanoma. Although immunological therapies such as T-VEC offer therapeutic promise, they carry a risk of immune-related adverse events (irAEs), the full spectrum of which is incompletely understood. We report a 63-year-old previously healthy man with cutaneous melanoma of the right ankle and progressive right lower extremity intransit metastases despite systemic therapy with immunomodulatory and molecularly targeted treatments...
July 27, 2018: Journal of Cutaneous Pathology
Thomas S Rogers, Laura McGevna, Deborah L Cook
Post-transplant lymphoproliferative disease (PTLD) is a rare lymphoid and/or plasmacytic proliferation that occurs in the context of immunosuppression due to solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (HSCT). PTLD is the most common cancer in children who receive a SOT or HSCT, occurring in up to 13% of these patients. The majority of PTLDs are extracutaneous B-cell lymphomas with only 12-14% representing the T-cell phenotype. PTLDs can involve the skin and behave like an aggressive lymphoma, and are among the most serious and potentially fatal complications of transplantation...
July 27, 2018: Journal of Cutaneous Pathology
Carolina Martinez-Ciarpaglini, Carlos Monteagudo
One of the most challenging tasks in dermatopathology practice is distinguishing fibroblastic, myofibroblastic, and smooth muscle differentiation in cutaneous spindle cells neoplasms. This article is protected by copyright. All rights reserved.
July 27, 2018: Journal of Cutaneous Pathology
Patrick O Emanuel, Aleodor A Andea, Claudia I Vidal, Tricia A Missall, Roberto A Novoa, Angela K Bohlke, Sarah R Hughes, M Yadira Hurley, Jinah Kim
BACKGROUND: The gold standard for the diagnosis of melanocytic lesions is histologic examination. However, as histologic examination can have its limitations, there are many clinical scenarios in which additional testing may be appropriate in an attempt to render a definitive diagnosis. METHODS: A literature review for three ancillary tests - comparative genomic hybridization (CGH)/ single nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression profiling by quantitative reverse transcription polymerase chain reaction (qRT-PCR) - was compiled and current use patterns were tabulated...
July 24, 2018: Journal of Cutaneous Pathology
Aadil Ahmed, Richard Scarborough, Rosa Gabriela, Anthony P Fernandez, Wilma Bergfeld
Dermatomyositis is a chronic inflammatory disorder of muscles and skin, presenting with muscle weakness, characteristic rash and classic serology findings. Histologically, cutaneous lesions show interface dermatitis with mild perivascular lymphocytic infiltrate and increased intradermal mucin. These findings are non-specific and the diagnosis is based on clinicopathologic correlation and serology results. However, variation in clinical presentation, serology and histology can make the diagnosis difficult and require cognizance of uncommon findings that may serve as a clue to the diagnosis...
July 24, 2018: Journal of Cutaneous Pathology
G Y Kim, L A Schmelkin, M D Davis, R A El-Azhary, C N Wieland, M D Leise, A Meves, J S Lehman
BACKGROUND: Graft-versus-host disease (GVHD) following solid organ transplantation (SOT) is extremely rare and infrequently described in the dermatologic literature. METHODS: We performed a retrospective clinicopathologic review of our institution's experience with patients diagnosed with SOT GVHD (May 1, 1996-September 1, 2017). RESULTS: Of 9 patients with SOT GVHD, 7 had undergone liver transplantation, while 2 had undergone lung transplantation...
July 23, 2018: Journal of Cutaneous Pathology
Judy Cheng, Jonathan Ho, Mary Barrett, Hye Jin Chung, Christina Lam
There exists a spectrum of solar elastotic variants based on clinical and histopathologic findings. We present here a peculiar case of solar elastosis that is unusual in its anatomic location, relative lack of background actinic damage, and pattern of linearization. Its presentation suggests that other factors in addition to UV radiation may play a role in the pathogenesis of solar elastosis. This article is protected by copyright. All rights reserved.
July 19, 2018: Journal of Cutaneous Pathology
Krishna Arudra, Ravi Patel, Michael T Tetzlaff, Sharon Hymes, Vivek Subbiah, Funda Meric-Bernstam, Carlos Torres-Cabala, Phyu P Aung, Priyadharsini Nagarajan, Adi Diab, Victor G Prieto, Kelly Nelson, Jonathan L Curry
Small-molecule inhibitors (nibs) have revolutionized cancer therapy with the emergence of clinically efficacious treatment for advanced-stage malignancies. Fibroblast growth factor receptor (FGFR) inhibitors have shown therapeutic efficacy in malignancies with molecular-genetic alterations in the FGFR/fibroblast growth factor pathway. In a phase 1 clinical trial, erdafitinib, a pan FGFR inhibitor, was well tolerated with a manageable toxicity profile. Hyperphosphatemia was a frequent adverse event in patients treated with erdafitinib; however, no serious complications were observed with this therapy...
July 18, 2018: Journal of Cutaneous Pathology
Yi-Chen Juan, Chih-Jung Chen, Cheng-Hsiang Hsiao, Tsu-Man Chiu
Microvenular hemangioma (MVH) is a rare benign vascular tumor with a controversial etiology, but hormone receptor alterations might be involved. We report a case of MVH in a 41-year-old Taiwanese woman who presented with a 1.5 × 1 cm violaceous plaque on left thigh that had appeared 1 year previously. She had taken oral contraceptives for several years and stopped 1 year prior to presentation. Histologically, the tumor was composed of small and compressed venous structures infiltrating in the dermis and subcutis...
July 17, 2018: Journal of Cutaneous Pathology
A Lamberti, C Miracco, F Scaramuzzino, E Cinotti, P Rubegni, M Fimiani
We described a case of a 78 year-old woman presenting to our attention for a six-month history of periungual lesions of the fingers associated with asthenia. The patient suffered from type 2 diabetes mellitus for 10-years and took oral hypoglycemic agents. This article is protected by copyright. All rights reserved.
July 11, 2018: Journal of Cutaneous Pathology
Hussein Nassereddine, Charlotte Fite, Diane Kottler, Vincent Descamps, Anne Couvelard, Liliane Marot, Lydia Deschamps
No abstract text is available yet for this article.
July 11, 2018: Journal of Cutaneous Pathology
Neda Shahriari, Jane M Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope
BACKGROUND: Melanoma remains a challenge to diagnose, especially when appearing on the background of chronically sun-damaged skin (CSDS). Our goal was to identify and quantify the reflectance confocal microscopy (RCM) features of melanoma on non-facial CSDS. METHODS: Included lesions were biopsy-proven melanomas, from anatomic sites other than the face, neck, scalp and acral skin, with histopathologic finding of solar elastosis in the underlying dermis. All included lesions underwent clinical, dermoscopic and RCM imaging, obtained in a standardized fashion, prior to biopsy...
July 4, 2018: Journal of Cutaneous Pathology
Marco Rovaris, Chiara Colato, Giampiero Girolomoni
Mycosis fungoides is predominantly a disease of older patients, but occasionally occurs in children. We report a rare case of CD8+/CD56+ mycosis fungoides with cytotoxic marker (perforin, TIA-1, and granzyme B) expression in a 10-year-old boy. Disease presented with three asymptomatic, slowly progressive erythematous and scaling plaques, surrounded by hypochromic alone in the left tight and lower trunk. UVB narrow band associated with topical corticosteroids resulted in complete remission in about 2 months, and no recurrence at 2-year follow-up...
July 2, 2018: Journal of Cutaneous Pathology
Aoisha Hoyle, Kerry Davies, Neil Rajan, Lucy Melly
Low-grade spiradenocarcinoma is a rare skin tumor, with fewer than six reported cases, arising in the context of CYLD cutaneous syndrome (CCS; syn: Brooke-Spiegler syndrome [BSS]). We report two independent cases of spiradenocarcinoma arising in a 50-year-old man with CCS. The tumors grew rapidly, prompting clinical excision. The histologic features in our cases corresponded to the salivary gland type basal cell adenocarcinoma-like pattern, low grade (BCAC-LG), that has been previously recognized as a recurrent finding in CCS...
July 2, 2018: Journal of Cutaneous Pathology
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