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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#1
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia, and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains two subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata , and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome, and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28343365/sox10-immunohistochemistry-in-sweat-ductal-glandular-neoplasms
#2
David S Cassarino, Albert Su, Bruce A Robbins, David Altree-Tacha, Seong Ra
BACKGROUND: SOX10 is a newer Schwannian and melanocytic marker that has generated great interest for its relative sensitivity and specificity in the diagnosis of neural crest-derived tumors. Previous studies with SOX10 have shown positive immunohistochemical expression in cutaneous eccrine glands and negative expression in eccrine ducts, apocrine glands, and hair follicles. Thus, we hypothesized that some sweat gland tumors of presumed eccrine origin would be positive for SOX10, whereas apocrine-derived sweat gland tumors would not...
March 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28342280/clinical-and-histopathological-features-of-cutaneous-manifestations-of-adult-onset-still-disease
#3
Erin Santa, Jeanne M McFalls, Joya Sahu, Jason B Lee
Adult-onset Still disease (AOSD) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis and hyperferritinemia. Skin findings accompany the disease in nearly 90% of the cases. Early reports described evanescent, pruritic, salmon-pink or urticarial lesions, referred to as the typical eruption of AOSD. Histopathologic findings consist of superficial perivascular dermatitis with varying number of interstitial neutrophils...
March 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28342276/primary-cutaneous-anaplastic-large-cell-lymphoma
#4
REVIEW
Ryanne A Brown, Sebastian Fernandez-Pol, Jinah Kim
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease.[1] CD30+ LPDs comprise approximately 25-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T cell neoplasm of the skin behind mycosis fungoides (MF).
March 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28337783/primary-cutaneous-anaplastic-large-cell-lymphoma-with-intralymphatic-involvement-associated-with-chronic-lymphedema
#5
Peiyuan Fan, Lin Nong, Jingru Sun, Xiaoqing Liu, Marshall E Kadin, Ting Li, Ping Tu, Yang Wang
Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B cell lymphoma. T cell malignancy has rarely been associated with chronic lymph stasis. Here we report a case of primary cutaneous anaplastic large cell lymphoma (pcALCL) with lymphatic spread associated with chronic lymphedema. The patient is a 56-year-old man who received orchiectomy and right inguinal lymphadenectomy for malignant seminoma 10 years ago, which led to prominent lymphedema of the right leg...
March 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28337777/syringocystadenocarcinoma-papilliferum-clinicopathologic-analysis-of-ten-cases
#6
Yan Zhang, Yun-Yi Kong, Xu Cai, Xu-Xia Shen, Jin-Cheng Kong
BACKGROUND: Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm. We aimed to investigate the clinicopathologic and immunophenotypic features of SCACP, and to discuss the prognosis of this rare entity. METHOD: We retrospectively collected clinical, pathological and follow-up data of 10 cases with SCACP. RESULTS: There were 8 males and 2 females, with ages ranging from 26 to 74 years. The chest was most frequently involved...
March 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28332233/tnf-inhibitor-associated-psoriatic-alopecia-diagnostic-utility-of-sebaceous-lobule-atrophy
#7
REVIEW
Olga K Afanasiev, Cathryn Z Zhang, Steven M Ruhoy
BACKGROUND: The increasingly successful and widespread use of TNF inhibitors (TNFi) to treat autoimmune and inflammatory conditions has also been accompanied by adverse reactions, both systemic and cutaneous. Psoriasiform cutaneous rashes are well described. Recently, TNF inhibitor associated psoriatic alopecia (TiAPA) is being more frequently reported. OBJECTIVE: The purpose of this study is to describe the features of TiAPA, including marked atrophy of sebaceous lobules as a histologic clue to diagnosis, helping to distinguish it from other types of alopecia...
March 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28299799/response-to-cup-l-003-2017-r1-cutaneous-papillary-adenocarcinoma-in-situ
#8
LETTER
Kalyani Patel, Hao Wu, Ashwin Pimpalwar, A Hafeez Diwan
No abstract text is available yet for this article.
March 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28294378/cutaneous-crohn-disease-with-superimposed-psoriasis-a-unique-case-with-overlapping-histology
#9
Ben J Friedman, Bahar Dasgeb, Jason B Lee
Crohn disease is an idiopathic, chronic inflammatory disorder of the gastrointestinal tract. We recently encountered a unique case in which a patient with longstanding Crohn disease presented with skin lesions with histopathologic features of both psoriasis and granulomatous inflammation suggestive of cutaneous Crohn disease. To our knowledge, this has not been described concomitantly in the same patient, in the same lesions. Review of the literature suggests that the intersection of these two histopathological reaction patterns may not be pure coincidence...
March 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28294400/chronic-amastigote-negative-cutaneous-leishmaniasis-a-clinical-histopathologic-and-molecular-study-of-27-cases-with-emphasis-on-atypical-and-pseudolymphomatous-presentations
#10
Carlo Tomasini, Laura Moneghini, Maria Barbui Anna
BACKGROUND: Chronic amastigote-negative cutaneous leishmaniasis (CL) is a diagnostic challenge, as the parasite load may be low, or absent in biopsy tissue sections. METHODS: A series of consecutive biopsy specimens, taken from 130 patients with a diagnosis of granulomatous dermatitis of unknown etiology, were reviewed. PCR was carried out for Leishmania-specific DNA. RESULTS: A total of 27/130 samples were positive for Leishmania-specific DNA...
March 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28266050/cutaneous-dermal-non-neural-granular-cell-tumor-is-a-granular-cell-dermal-root-sheath-fibroma
#11
Angel Fernandez-Flores, David S Cassarino, Erica Riveiro-Falkenbach, José Luis Rodriguez-Peralto, Maria Teresa Fernandez-Figueras, Carlos Monteagudo
Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified. It was also demonstrated that not all cases were polypoid. In the current study we try to further characterize this entity by presenting five cases of NNGCT. As expected, not all of them were polypoid...
March 7, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28256051/histopathological-assessment-of-oasis-ultra-on-critical-sized-wound-healing-a-pilot-study
#12
Daniel Dante Yeh, Rosalynn M Nazarian, Leah Demetri, Tomaz Mesar, Suzan Dijkink, Andreas Larentzakis, George Velmahos, Karim Walid Sadik
BACKGROUND: Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS® Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post-traumatic and infective wounds treated with OASIS using histological markers of repair. METHODS: Adults with traumatic, infective or iatrogenic wound defects with size precluding primary closure were eligible...
March 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28252209/palisaded-granulomatous-dermatitis-secondary-to-recombinant-insulin
#13
LETTER
Kiran Motaparthi
No abstract text is available yet for this article.
March 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28244118/late-latent-mucinous-syphilis-mimicking-connective-tissue-disease
#14
S P Gottesman, Y S Schoenling, K S Culpepper
As evidenced by the CDC statistics, syphilis is yet again on the rise. It is known as the great mimicker because of its variable symptoms and how frequently it can be confused with other diseases. The different stages of syphilis (primary, secondary, latent, late latent and tertiary) are discussed. We describe a new histopathologic pattern of syphilis, one that mimics connective tissue disease and can represent a diagnostic pitfall. In this time and age when syphilis is rising especially among the men who have sex with men subgroup, it is important to keep a high index of suspicion of syphilis even when clinically and histopathologically the findings on first glance may not appear characteristic...
February 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28233342/four-cases-of-pediatric-deep-seated-subcutaneous-pyogenic-granuloma-review-of-literature-and-differential-diagnosis
#15
Juan Putra, Beth Rymeski, A Carl Merrow, Roshni Dasgupta, Anita Gupta
BACKGROUND: Pyogenic granulomas are benign, reactive, typically superficial vascular lesions that can be idiopathic or arise secondary to trauma, underlying vascular malformations, infections, physiologic or pathologic endocrine changes, and hormone therapy. Deep-seated/subcutaneous pyogenic granulomas (DSPG) are rarely seen in any age group. Pediatric DSPGs can be a clinical and pathologic challenge because these lesions mimic other vascular lesions, including kaposiform hemangioendothelioma, infantile hemangiomas, and vascular malformations...
February 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28211590/genital-folliculo-sebaceous-cystic-hamartoma-a-claim-of-the-stroma-as-a-clue-in-the-diagnosis-of-proliferations-with-follicular-differentiation
#16
Victoria Alegría-Landa, Margarita Jo Velasco, Lucía Prieto-Torres, Luis Requena
Folliculo-sebaceous hamartomas comprise a series of entities whose boundaries are imprecise. We present the clinical case of a folliculo-sebaceous cystic hamartoma of genital localization where the diagnosis was established based on the epithelial proliferation, but mostly, on the characteristic stroma. Because this lesion lacked of the cystic component, we mention the most frequent differential diagnoses and review the literature of the few cases published on this infrequent localization.
February 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28198027/the-histopathology-of-cutaneous-polyarteritis-nodosa-and-its-relationship-with-lymphocytic-thrombophilic-arteritis
#17
LETTER
Edmund Wee, Robert I Kelly
No abstract text is available yet for this article.
February 15, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28195354/histopathology-of-bilateral-lower-extremity-inflammatory-lymphedema-in-military-basic-trainees-a-leukocytoclastic-vasculitis-of-the-deep-vascular-plexus
#18
Shannan E McCann, Scott R Dalton, Todd T Kobayashi
Bilateral lower extremity inflammatory lymphedema (BLEIL) is a recently described condition that presents with exquisite tenderness, erythema, and edema of the lower leg, ankle and dorsal foot resembling an acute cellulitis. It was first reported in healthy, young adult military basic trainees with a normal body mass index during the first 72 hours of arrival to basic training. It occurs while standing at attention for many hours, and shows rapid resolution with elevation and rest. We report an additional case of BLEIL and describe the histopathology of this case and two of the previously reported cases...
February 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28169467/radiation-associated-angiosarcoma-in-the-setting-of-breast-cancer-mimicking-radiation-dermatitis-a-diagnostic-pitfall
#19
Brianne H Daniels, Jennifer S Ko, J Jordi Rowe, Erinn Downs-Kelly, Steven D Billings
BACKGROUND: We have encountered cases of postradiation angiosarcoma (PRAS) histologically mimicking radiation dermatitis. METHODS: Cases of PRAS from institutional/consultation archives from 2006-2016 were reviewed. For inclusion, tumors had to have inapparent/subtle tumor at low magnification and scattered individual tumor cells resembling radiation fibroblasts. Prior ancillary studies were reviewed, with additional immunostains performed as needed. RESULTS: Ten met criteria...
February 7, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28164358/cutaneous-papillary-adenocarcinoma-in-situ
#20
LETTER
Masoud Asgari, Sheng Chen
No abstract text is available yet for this article.
February 6, 2017: Journal of Cutaneous Pathology
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