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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/27886404/adipophilin-expression-in-cutaneous-malignant-melanoma
#1
Masakazu Fujimoto, Ibu Matsuzaki, Yuki Yamamoto, Akihiko Yoshizawa, Kenji Warigaya, Yoshifumi Iwahashi, Fumiyoshi Kojima, Fukumi Furukawa, Shin-Ichi Murata
BACKGROUND: The lipogenic pathway is upregulated in cancer cells, including melanomas. However, the pathological significance of cellular lipids in melanocytic lesions has yet to be determined. In this study, we evaluated intracytoplasmic lipid droplets in melanocytic nevi (MNs) and malignant melanomas via immunohistochemical analysis of adipophilin (ADP), which coats lipid droplets. METHODS: One hundred primary cutaneous melanocytic lesions (33 MNs, 17 melanomas in situ [MIS], and 50 invasive melanomas [IMs]) were immunostained for ADP...
November 25, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27873341/immunostain-use-in-the-diagnosis-of-melanomas-referred-to-a-tertiary-medical-center-a-15-year-retrospective-review-2001-2015
#2
Randie H Kim, Shane A Meehan
BACKGROUND: Little is known regarding the clinical practice of immunohistochemistry in the diagnosis of melanoma. We aimed to assess the incidence of immunostain usage by referring pathologists and dermatopathologists in melanoma cases sent for consultative review. As a secondary objective, associations between immunostain use and specific melanoma characteristics were also evaluated. METHODS: This is a retrospective review of consultation reports of referred melanomas at a tertiary academic center in New York, New York from 2001-2015...
November 22, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27859509/etv6-rearrangement-in-a-case-of-mammary-analog-secretory-carcinoma-of-the-skin-comment-on-chang-et-al-2016
#3
LETTER
David Creytens, Liesbeth Ferdinande, Jo Van Dorpe
No abstract text is available yet for this article.
November 17, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27859475/correlation-between-histopathologic-features-and-likelihood-of-identifying-superficial-dermatophytosis-with-periodic-acid-schiff-diastase-staining-a-cohort-study
#4
Michael Z Wang, Ruifeng Guo, Julia S Lehman
BACKGROUND: Periodic Acid Schiff-Diastase (PAS-D) staining is used routinely in dermatopathology. Conventionally, parakeratosis or intracorneal neutrophils justify use of PAS-D stain to identify dermatophytosis. We aimed to investigate the histopathological features of superficial dermatophytosis. METHODS: Skin biopsies with PAS-D stain were retrospectively reviewed by a blinded dermatopathologist. Histopathologic findings in cases with dermatophytosis were compared to those without...
November 17, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862191/significance-of-epidermal-mitoses-in-challenging-melanocytic-proliferations
#5
Eugen C Minca, Steven D Billings, Paul Elson, Michael T Tetzlaff, Aleodor A Andea, Jennifer S Ko
BACKGROUND: Accurate diagnosis of melanoma remains histologically challenging. Dermal mitoses support malignancy, but are only occasionally seen in melanomas. Since melanomagenesis is thought to begin at the dermal-epidermal junction, we investigated the significance of epidermal melanocytic mitoses (EM) in a spectrum of lesions with molecular characterization. METHODS: EM density (EMD) was evaluated in 46 straightforward lesions (24 benign, 22 malignant) and 30 challenging lesions with expert interpretation, fluorescence-in-situ-hybridization, and myPath-score characterization (12 favor-benign, 9 favor-malignant, 9 ambiguous)...
November 15, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862184/serum-sickness-like-drug-reaction-two-cases-with-a-neutrophilic-urticarial-pattern
#6
Cuong V Nguyen, Daniel D Miller
The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A Pubmed literature search revealed only 5 existing cases of SSLR with described cutaneous histopathologic features. We report two cases of serum sickness-like reaction, one each to bupropion and cefazolin. Skin biopsy findings in both cases demonstrated a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862162/erythema-multiforme-like-cutaneous-lesions-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-a-rare-case-report
#7
Kumpol Aiempanakit, Chitiarpa Amatawet, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate, Kanita Kayasut, Supaporn Suwiwat, Benjawan Apinantriyo
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), also known as Type II enteropathy-associated T-cell lymphoma (EATL), is an aggressive peripheral T-cell lymphoma. EATL generally presents in adults with gastrointestinal symptoms. Skin involvement is very rare, found only in approximately five percent of patients. The authors report a 67-year-old Asian male who presented with chronic diarrhea and developed erythema multiforme-like cutaneous lesions. A skin biopsy revealed extensive pagetoid spread of atypical lymphocytes in the epidermis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862152/cutaneous-polyarteritis-nodosa-localized-to-a-region-of-lymphedema-secondary-to-streptococcus-viridans-cellulitis-and-multiple-surgeries
#8
Andrew Matsumoto, Rami N Al-Rohil, Marina Bravin, Lori Anderson, Danielle Wroblewski, J Andrew Carlson
Cutaneous polyarteritis nodosa (CPAN) is a chronic, indolent, single organ arteritis that generally presents with lower extremity nodules and/or livedo racemosa, accompanied by malaise and arthralgias. CPAN is often triggered by infection, commonly Group A streptococcal species, and is considered an autoimmune reaction. Scarring from surgery and obliterative lymphangiitis from bacterial cellulitis are causes of lymphedema. Lymphedematous skin is predisposed to autoimmune disorders. Herein we report a 53yo woman who developed CPAN restricted to a localized area of the right upper arm-shoulder that had undergone multiple surgeries, complicated by episodes of Streptococcus viridans cellulitis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27862142/reply-to-cd123-immunohistochemistry-for-plasmacytoid-dendritic-cells-is-useful-in-the-diagnosis-of-scarring-alopecia-three-pdc-related-parameters-are-useful-in-differentiating-lupus-alopecia-from-lpp
#9
LETTER
https://www.readbyqxmd.com/read/27859479/diverse-types-of-dermatologic-toxicities-from-immune-checkpoint-blockade-therapy
#10
REVIEW
Jonathan L Curry, Michael T Tetzlaff, Priyadharsini Nagarajan, Carol Drucker, Adi Diab, Sharon R Hymes, Madeleine Duvic, Wen-Jen Hwu, Jennifer A Wargo, Carlos A Torres-Cabala, Ronald P Rapini, Victor G Prieto
Immunomodulatory drugs that leverages host immune mechanisms to destroy tumor cells has been met with great promise in the treatment of cancer. Immunotherapy, targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have shown tremendous improvements in the survival of patients with advanced solid tumors. However, the development of dermatologic toxicity (DT) is a consequence to immunotherapy. Review of published reports of the DT to immunotherapy revealed patients receiving anti-CTCLA-4 antibody or anti-PD-1/PD-L1 antibody often develop a DT of any type and grade...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27859466/the-expression-of-podoplanin-is-associated-with-poor-outcome-in-cutaneous-squamous-cell-carcinoma
#11
Javier Cañueto, Ester Cardeñoso-Álvarez, Adriana Cosano-Quero, Ángel Santos-Briz, Emilia Fernández-López, Jesús Pérez-Losada, Concepción Román-Curto
BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and can be both locally invasive and metastatic at distant sites. While research efforts have been made to predict poor outcome of CSCC, there is a lack of knowledge regarding molecular markers. PODOPLANIN has been associated with poor outcome in several types of cancer including CSCC, but this is controversial and only a few studies have evaluated the prognostic implications of Podoplanin in the development of this tumor...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27859477/primary-cutaneous-adenoid-cystic-carcinoma-with-myb-aberrations-report-of-three-cases-and-comprehensive-review-of-the-literature
#12
Carlos N Prieto-Granada, Lei Zhang, Cristina R Antonescu, Jean M Henneberry, Jane L Messina
Adenoid cystic carcinoma (ACC) is a relatively rare slow-growing and often-aggressive epithelial-myoepithelial neoplasm that arises in multiple organs including the skin. The t(6;9) (q22-23;p23-24) translocation, resulting in a MYB-NFIB gene fusion has been found in ACCs from the salivary glands and other organs. Recently, MYB aberrations occurring in a subset (40%) of primary cutaneous ACC (PCACC) examples was described. Herein, we report three additional cases of PCACC harboring MYB aberrations. The tumors presented in three males aged 43, 81 and 55 years old and affected the extremities in the first two patients and the scalp in the third one...
November 8, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27910123/congenital-infantile-fibrosarcoma-mimicking-a-cutaneous-vascular-lesion-a-case-report-and-review-of-the-literature
#13
Tyler Enos, Gregory A Hosler, Naseem Uddin, Adnan Mir
Congenital infantile fibrosarcoma (CIFS) is a rare neoplasm of infancy that occurs most frequently in the extremities, and when presenting in the skin, may sometimes resemble infantile hemangiomas or other vascular lesions. Clinically, these tumors differ from hemangiomas in the time of onset, morphology, and growth pattern and must be evaluated histologically for definitive diagnosis. We describe an infant with a neoplasm involving the distal left forearm initially presumed to be a vascular lesion after evaluation by two separate ultrasound studies...
November 7, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27813137/generalized-multinucleate-cell-angiohistiocytoma-case-report-and-literature-review
#14
Ming Wang, Bilal Abdul-Fattah, Cuiyan Wang, Yun Zhao, Xiaoying Qu, Maher Al-Muriesh, Xia Wang, Li Zhu, Yue Qian, Changzheng Huang, Siyuan Chen
BACKGROUND: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign fibrohistiocytic and vascular proliferation, which usually occurs as slow-growing grouped reddish-brown to purple papules and nodules on the distal extremities or face. Patients with generalized MCAH are extremely rare and to our knowledge, there are no more than 11 cases reported previously in the medical literature. OBJECTIVE: To describe the clinical, histopathologic features and immunohistochemical characteristics of all reported cases of generalized MCAH and investigate any potential clinicopathological correlations...
November 4, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27804154/acquired-hemangioma-with-features-of-dabska-tum-or-an-additional-case
#15
LETTER
María-Teresa Fernández-Figueras, Francisco-José López-Gil
No abstract text is available yet for this article.
November 2, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27792259/in-situ-carcinoma-in-a-hybrid-cyst-a-case-report
#16
Kayhan Başak, Pınar Y Başak
Follicular hybrid cysts including two or more components of the epithelial skin adnexa are very rare. The epithelial lining of hybrid cysts varies, and either contains epidermis, and trichilemmal squamous epithelium, or other epithelia of the skin adnexa. Hybrid cysts may also be associated with neoplasia, such as in situ carcinoma, Bowen's disease and squamous cell carcinoma. A 37-year-old female was complaining of a cyst on her scalp. The unilocular cystic lesion was lined with markedly atypical squamous cells with trichilemmal differentiation...
October 28, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27778368/a-proposed-classification-for-follicular-involvement-by-melanoma
#17
B Joel Tjarks, Najwa Somani, Melissa Piliang, Wilma F Bergfeld
BACKGROUND: Folliculotropism in melanoma is poorly characterized and standard categorization for follicular involvement by melanoma is unavailable. We propose a logical categorization system. METHODS: We conducted a search of our archives over a 24 year period for cases mentioning the terms follicle, follicular, folliculotropic, folliculocentric, AND melanoma. RESULTS: We identified 90 cases of melanoma with involvement of the hair follicle...
October 25, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27778364/primary-dermal-pleomorphic-liposarcoma-utility-of-adipophilin-and-mdm2-cdk4-immunostainings
#18
Jose L Ramírez-Bellver, Joaquín López, Elena Macías, Victoria Alegría-Landa, Ignacio Gimeno, Alejandra Pérez-Plaza, Heinz Kutzner, Luis Requena
Liposarcoma, usually arises in deep soft tissues and pleomorphic liposarcoma (PL), is the rarest histopathologic variant. However, 15 cases of entirely dermal PL have been reported. We describe a case of a 79-year-old man who developed a rapidly growing nodule on his thorax. Excisional biopsy was performed and immunohistochemical studies were carried. The lesion was a well-circumscribed dermal nodule composed of multivacuolated pleomorphic lipoblasts and atypical mitotic figures. Neoplastic cells expressed CD10 and resulted negative S100 protein, Melan-A, MITF-1, AE1/AE3, CD4, CD68 (PGM1), retinoblastoma gene family protein, pericentrine and lysozyme...
October 24, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27774635/comments-on-cutaneous-surgical-specimen-shrinkage
#19
Gene K Potter
No abstract text is available yet for this article.
October 24, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27766668/two-histopathological-patterns-of-postinflammatory-hyperpigmentation-epidermal-and-dermal
#20
Ji-Youn Park, Ji-Hye Park, Sang Jin Kim, Ji Eun Kwon, Hee Young Kang, Eun-So Lee, You Chan Kim
BACKGROUND: Postinflammatory hyperpigmentation (PIH) commonly occurs, but the histopathological features are not well characterized. METHODS: A total of 21 PIH patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin were performed. Sections were stained with hematoxylin-eosin, Fontana-Masson, NKI/beteb, microphthalmia-associated transcription factor (MITF), CD68, c-kit, factor XIIIa, MMP-2 and MMP-9. RESULTS: Fontana-Masson-stained sections suggested two obvious PIH groups: epidermal (13 cases) and dermal (8 cases) pigmentation...
October 21, 2016: Journal of Cutaneous Pathology
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