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Journal of Cutaneous Pathology

Jacqueline Deen, Leith Banney, Joanna Perry-Keene
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a histopathological diagnosis, characterized by a pattern of granulomatosis, which may be associated with leukocytoclastic vasculitis. PNGD most commonly occurs in association with systemic inflammatory disorders, typically autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythromatosus. There are very rare reports of PNGD in patients with lymphoma. We report the case of a 53-year-old female with an erythematous, papular eruption occurring in association with Hodgkin lymphoma...
December 11, 2017: Journal of Cutaneous Pathology
Caitlin Porubsky, Jamie K Teer, Yonghong Zhang, Maria Deschaine, Vernon Sondak, Jane L Messina
Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi that underwent genetic analysis to further characterize the mutational profile of this rare entity.
December 6, 2017: Journal of Cutaneous Pathology
B J Friedman, J Sahu, C C Solomides, D M Connolly, J B Lee
Syringocystadenoma papilliferum (SCAP) is a benign adnexal neoplasm with apocrine differentiation.1,2 which may be derived from pluripotent cells.3 The lesion may develop within a pre-existing nevus sebaceus, but the majority of cases arise sporadically.3 Congenital lesions in a Blaschkoid distribution have also been reported, and these cases are thought to represent genetic mosaicism.4,5,6 The tumor has a varied clinical appearance, but typically presents as a raised warty, hairless plaque or nodule.3.
December 5, 2017: Journal of Cutaneous Pathology
M Llamas-Velasco, T Mentzel, A Rütten
Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published; nine of them showed the ETV6-NTRK3 translocation and an additional case had a heterozygous deletion of ETV6 in 25% of cells (Table 1).1-7 These cutaneous tumors are related to secretory breast carcinoma (SBC) and mammary analogue secretory carcinoma (MASC) from the salivary glands, with all sharing a balanced chromosomal translocation of t(12;15)(p13;q25) that leads to ETV6-NTRK3 gene fusion.
December 4, 2017: Journal of Cutaneous Pathology
Gauri Panse, Veerle Bossuyt, Christine J Ko
Non-mammary metastases involving breast are rare and most commonly involve the breast parenchyma. Infrequently, metastasis from an extramammary primary site presents as inflammatory carcinoma over the breast. Diagnosis of such lesions can be challenging, especially in patients with co-existing primary breast carcinoma. Few such cases have been described in literature; however, none of the previously reported cases had a prior history of primary breast carcinoma. We present two patients with history of breast carcinoma and serous carcinoma of ovarian/peritoneal origin that presented with inflammatory carcinoma over the breast...
December 1, 2017: Journal of Cutaneous Pathology
Andrew Dunn, Brannon G Broadfoot, Jennifer Hunt, Jennifer R Kaley, Omar Atiq, Narendra Babu Gutta, Xiaofei Wang, Jerad M Gardner, Sara C Shalin
Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical carcinoid tumors were considered synonymous; however, laryngeal LCNEC has been shown to have higher mitotic rates and worse prognosis, which has led to laryngeal LCNEC to be separated from atypical carcinoid and classified as a poorly differentiated neuroendocrine carcinoma in the most recent World Health Organization classification...
December 1, 2017: Journal of Cutaneous Pathology
Xinyi Ma, Guihua Wang, Aditya Kuwadekar, Min Zhao, Weili Hu, Yeqin Wu, Zhongliang Yi, Xianen Xu, Li Xu
Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC, Our review of the literature revealed only 17 previously identified cases. We report the case of a 47-year-old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high-power fields with a Ki-67 proliferative index approximated at 5%...
November 28, 2017: Journal of Cutaneous Pathology
Manuel Valdebran, Justin Bandino, Amira Elbendary, Abdallah Gad, Sri Krishna Chaitanya Arudra, Sébastien de Feraudy, Dirk M Elston
BACKGROUND: Interpretation of Clark's nevi has generated debate over the years; although criteria has been proposed for grading morphological features of melanocytes, there is still confusion and variability in the assessment of these lesions. METHODS: This is a retrospective observational study conducted on 100 Clark's nevi and 84 melanomas. A single expert dermatopathologist evaluated all blinded and randomized photomicrographs of both the Clark's nevi and melanomas for the presence of 14 cytologic features...
November 28, 2017: Journal of Cutaneous Pathology
Brian J King, Julia S Lehman, William R Macon, Gabriel F Sciallis
Cutaneous tattoo reactions are most often seen to red tattoo ink.1 Spongiotic, lichenoid, psoriasiform, granulomatous, and pseudolymphomatous inflammatory reaction patterns have been described.2 Those dyes containing mercury sulfide (cinnabar) are thought to be particularly reactive although the more recently utilized organic red pigments are reactive and can manifest as exuberant delayed hypersensitivity reactions.
November 28, 2017: Journal of Cutaneous Pathology
S Chahal, B Tallon
Psoriasis is a common, chronic, relapsing skin eruption characterized by abnormal hyperproliferation of the epidermis. Clinically, it typically consists of well-circumscribed erythematous plaques with a silvery white scale in its plaque form, located usually on the extensor surfaces of the extremities, sacral region, scalp and nails. There are a number of clinical variants, including guttate, pustular and erythrodermic psoriasis.
November 28, 2017: Journal of Cutaneous Pathology
Neda Shahriari, Jane M Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope
Reflectance confocal microscopy (RCM) is a technology utilized for bedside diagnosis of cutaneous pathology by non-invasive, in vivo, cellular-level imaging. With the recent establishment of reimbursement codes by the US Centers for Medicaid and Medicare Services (CMS), RCM is now likely to be employed by clinical dermatologists and impact decision making on skin cancer management. Dermatopathologists, therefore, would benefit from learning how to interpret RCM images and how RCM findings correlate with histopathological criteria of diagnosis...
November 27, 2017: Journal of Cutaneous Pathology
Cassie Fives, Cynthia C B B Heffron
BACKGROUND: Wide local excisions (WLE) are frequently undertaken in the management of cutaneous melanoma; however there is considerable variability in their macroscopic sampling. The aim of our study was to establish evidence-based guidelines for the macroscopic handling of these specimens with a subsequent review of the impact on our service. METHODS: The study group of 128 cases with initial biopsy and subsequent WLE in our institution in 2010 were identified by a computer-generated search...
November 23, 2017: Journal of Cutaneous Pathology
Vicente Exposito-Serrano, Eugenia Agut-Busquet, Lorena Leal Canosa, Jose Herrerías Moreno, Amparo Saez, Jesús Luelmo
A cutaneous mastocytoma (CM) is a clinical variant of cutaneous mastocytosis. It is defined as the presence of up to 3 isolated mast cell skin lesions. When only 1 lesion is observed, the patient is classified as having a solitary mastocytoma, and when 4 or more lesions are observed, the patient should be classified as having urticaria pigmentosa (1).
November 17, 2017: Journal of Cutaneous Pathology
Patrick S Rush, Jason N Rosenbaum, Madhuchhanda Roy, Rebecca M Baus, Daniel D Bennett, Ricardo V Lloyd
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging...
November 17, 2017: Journal of Cutaneous Pathology
Justin D Richey, Benjamin J Chen, April C Deng
It is well known that patients infected with human immunodeficiency virus type I (HIV-1) are more likely to develop malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma, and anal and cervical carcinomas.
November 2, 2017: Journal of Cutaneous Pathology
Michael T Tetzlaff
In this issue of the Journal of Cutaneous Pathology, Tjarks et al. present a study that advances our understanding of the diagnosis of sebaceous neoplasms (in particular, sebaceous carcinoma) and the lesions that mimic them (1).
October 31, 2017: Journal of Cutaneous Pathology
Lynette Ying Lee, Rama Namuduri, Michelle Mei Fung Chan, Jeffrey Kim Siang Quek, Mark Jean-Aan Koh
Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma (NHL) with subtypes that can be distinguished on the basis of clinical, immunophenotypic, morphologic, and molecular characteristics. The genital tract as a primary site for NHL is very rare (1).
October 31, 2017: Journal of Cutaneous Pathology
S van Santen, P M Jansen, M H Vermeer, R Willemze
Folliculotropic mycosis fungoides (FMF) is a rare but distinct variant of mycosis fungoides (MF), histologically characterized by the presence of folliculotropic infiltrates, often with sparing of the epidermis, and clinically by the preferential involvement of the head and neck region.(1).
October 31, 2017: Journal of Cutaneous Pathology
Lauren A Penn, Nooshin Brinster
BACKGROUND: Calciphylaxis and pseudoxanthoma elasticum (PXE) are rare, clinically distinct, disorders that share a common feature of cutaneous calcification that vary widely in their cutaneous presentation. METHODS: We conducted a descriptive, retrospective review of biopsy specimens collected over a two-year period. Only specimens with a histologic and clinical diagnosis of calciphylaxis were included in the review. Specimens were then histologically examined for features of pseudoxanthoma elasticum in the dermis and/or subcutaneous fat, utilizing hematoxylin and eosin staining...
October 31, 2017: Journal of Cutaneous Pathology
Nneka Comfere, Uma Sundram, M Yadira Hurley, Brian Swick
BACKGROUND: Appropriate use criteria have been developed for many tests using expert judgment, evidence-based practice, and clinical experience. In this context, the opinions of practitioners about clonality assays in various clinical scenarios where cutaneous lymphoma is suspected are reported. METHODS: An Appropriate Use Criteria Task Force sponsored by the American Society of Dermatopathology (ASDP) synthesized clinical scenarios for cutaneous lymphoproliferative disorders (LPD)...
October 30, 2017: Journal of Cutaneous Pathology
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