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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/28715085/nail-histology-processing-techniques-what-is-happening-around-the-world
#1
Adam Rubin
In this issue of the Journal of Cutaneous Pathology[1], Wlodek et al present data from an international survey of members of the Council for Nail disorders and the European Nail Society regarding nail histology processing techniques. This is an important contribution to the nail pathology literature as few existing publications address the topics investigated by the survey.
July 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28708295/cd13-is-a-marker-for-onychofibroblasts-within-nail-matrix-onychodermis-comparison-of-its-expression-patterns-in-the-nail-unit-and-in-the-hair-follicle
#2
Ji-Hye Park, Dong-Youn Lee, Kee-Taek Jang, Sang-Yun Ha, Ghee Young Kwon, Kyung-Hoon Lee, Jong Sup Shim, Eun Ji Kwon
BACKGROUND: We previously demonstrated the presence of onychodermis, a specialized mesenchymal cell population beneath the the nail matrix and proximal nail bed demonstrating CD10 expression. We hypothesize that the onychodermis could be the nail analog of the follicular dermal papilla, which is known to express CD13. We compare CD13 expression patterns between specialized mesenchymes of nail and hair, and compare these findings with CD10 expression patterns. METHODS: CD10 and CD13 immunohistochemisty was performed on polydactyly and adult cadaveric nail units, and on hair follicles in scalp nevus sebaceus excision specimens...
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28708250/cutaneous-syncytial-myoepithelioma-a-recently-described-neoplasm-which-may-mimic-nevoid-melanoma-and-epithelioid-sarcoma
#3
Ahmed K Alomari, Noah Brown, Aleodor Andea, Bryan L Betz, Rajiv M Patel
Myoepithelial cells possess dual immunohistochemical and ultrastructural features of smooth muscle cells and epithelial cells and are capable of divergent differentiation (1). As such, benign and malignant tumors of myoepithelial cells show a spectrum of morphologies and have been reported in a variety of anatomic locations, including but not limited to, the breast, larynx, soft tissues, salivary glands and more recently the skin (2-6).
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28707759/columnar-dyskeratosis-a-clue-to-wong-type-dermatomyositis
#4
LETTER
Andrew Matsumoto, Richard Wang, John Andrew Carlson
No abstract text is available yet for this article.
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28695627/verrucous-candidiasis-of-the-orolabial-mucosa-a-clinicopathologic-series
#5
Kiran Motaparthi, Jyoti P Kapil, Jose A Plaza
Chronic hyperplastic candidiasis (CHC) is described within the oral mucosa and the most commonly affected sites are the buccal commissures, cheeks, palate and tongue. In the oral, pharyngeal, and laryngeal mucosae, verrucous epidermal hyperplasia (VEH), pseudocarcinomatous hyperplasia (PCH), epithelial dysplasia, and a verrucous clinical appearance have all been reported in association with CHC.
July 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28685839/lipoid-proteinosis-a-case-with-distinct-histopathological-and-radiological-findings
#6
B K Brar, S Jain, S K Brar
Lipoid proteinosis is a rare inherited genodermatosis characterized by hyaline deposits in various tissues. Clinically, it manifests with cutaneous as well as extracutaneous features. PAS reactive hyaline deposits in the upper dermis, with localization around blood vessels and eccrine sweat glands, in particular, is the histopathological hallmark finding. On brain imaging, bilateral symmetrical temporal lobe calcifications are considered to be pathognomonic of this disorder. We report a case of lipoid proteinosis in which hyaline deposits were present in the papillary and reticular dermis, without being seen at the periphery of eccrine sweat glands, along with dystrophic calcification...
July 7, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28675516/psoriasiform-graft-versus-host-disease-distributed-along-blaschko-s-lines
#7
Philip B Milam, Sumithra V Vasu, Alejandro A Gru, Benjamin H Kaffenberger
The skin is one of the most frequently affected organs in chronic graft-versus-host disease (cGVHD). Cutaneous involvement of cGVHD presents varied features from lichenoid to sclerodermiform changes that some clinicians may find difficult to accurately diagnose, particularly when the cGVHD mimics other disease processes.
July 4, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28675468/acral-angiokeratoma-like-pseudolymphoma-in-a-middle-aged-woman
#8
Shamir Geller, Alina Markova, Melissa Pulitzer, Patricia L Myskowski
Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59 year old woman who presented with an unusual unilateral, clustered aggregate of scaly violaceous papules on the toe with an indolent course. Skin biopsy showed a prominent vascular proliferation associated with a dermal infiltrate of monoclonally rearranged T-follicular helper phenotype T-cells, in keeping with CD4+ small/medium T-cell lymphoproliferative disorder (SMPTC-LPD)...
July 4, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28675457/metastatic-sarcomatoid-renal-cell-carcinoma-manifesting-as-a-subcutaneous-soft-tissue-mass
#9
Valentina Logunova, Olayemi Sokumbi, Kenneth A Iczkowski
Spindle cell lesions of the superficial soft tissues often pose a diagnostic challenge due to frequently non-specific clinico-radiologic presentation and overlapping microscopic features, therefore immunohistochemistry remains a favored approach in separating them.
July 4, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28671710/adult-xanthogranuloma-diagnosed-on-reflectance-confocal-microscopy
#10
Attiya Haroon, Shahram Shafi, Babar Rao
No abstract text is available yet for this article.
July 3, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28671291/apocrine-carcinoma-with-neuroendocrine-differentiation
#11
Taichi Imamura, Fumi Kuwahara, Hiroshi Saruta, Takekuni Nakama, Chika Ohata
No abstract text is available yet for this article.
July 3, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28657121/differential-ube2c-and-hoxa1-expression-in-spitz-nevus-and-melanoma
#12
Stefan Kraft, Johanna B Moore, Alona Muzikansky, Kenneth L Scott, Lyn M Duncan
BACKGROUND: Recent molecular advances suggest that Spitz nevi and other spitzoid neoplasms are biologically distinct from melanoma and conventional nevi. The ubiquitin ligase UBE2C and the homeobox transcription factor HOXA1 are candidate oncogenes in melanoma. METHODS: Using RNA expression analysis and immunohistochemistry, we evaluated these biomarkers in Spitz nevi (n = 20) melanoma (n = 20), and by immunohistochemistry in conventional nevi (n = 20)...
June 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28644551/erythema-multiforme-like-lesions-in-primary-cutaneous-aggressive-cytotoxic-epidermotropic-cd8-t-cell-lymphoma-a-diagnostic-and-therapeutic-challenge
#13
Carlo Tomasini, Mauro Novelli, Daniele Fanoni, Emilio Francesco Berti
Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (pCAECD8+ CTCL), is an extremely rare, rapidly progressing cutaneous lymphoma, with frequent systemic involvement, first recognized as a distinct clinicopathologic entity by Berti et al in 1999. (1) As the name suggests, this entity has an aggressive behavior and exhibits marked epidermotropism on histopathologic analysis. Conventional treatment modalities for classic CTCL are often ineffective and the prognosis is poor with a median survival of 12 months...
June 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632950/fibroblastic-connective-tissue-nevus-clinicopathological-and-immunohistochemical-study-of-14-cases
#14
Ilaria Pennacchia, Heinz Kutzner, Dmitry V Kazakov, Thomas Mentzel
BACKGROUND: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labelled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS: Eight patients were male and five were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Histologically, all cases were composed of bundles of bland spindle cells of fibroblastic/myofibroblastic lineage irregularly branching within the reticular dermis and along fibrous septa in the subcutis...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632948/nodular-cutaneous-amyloidoma-of-the-extremity-secondary-to-chronic-granulomatous-inflammation-in-setting-of-sarcoidosis
#15
Victoria Billero, Audrey A Jacobsen, Mariya I Miteva, Adam J Wulkan, Claudio Marasca, Roanelli Paolo
Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities(1) . Soft tissue amyloidomas on the extremities have been associated with chronic inflammation, particularly when accompanied by AA-type amyloid deposition as seen in local trauma, surgery, hypertension, and diabetes(2) . To our knowledge, this is the first reported case of nodular cutaneous amyloidoma in the setting of systemic and cutaneous sarcoidosis. A 65-year-old woman presented with an asymptomatic subcutaneous nodule above her left lateral malleolus...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632917/miniaturization-of-sebaceous-glands-a-novel-histopathological-finding-in-pemphigus-vulgaris-and-pemphigus-foliaceus-of-the-scalp
#16
Marta Sar-Pomian, Joanna Czuwara, Lidia Rudnicka, Malgorzata Olszewska
BACKGROUND: Intraepidermal acantholysis is a characteristic histopathological feature of pemphigus. The histopathology of scalp biopsies in pemphigus has not been widely discussed in the literature, although the scalp is commonly involved in pemphigus. METHODS: A total of 32 consecutive patients with scalp involvement (seventeen with pemphigus vulgaris and fifteen with pemphigus foliaceus) were enrolled into the study. The histopathological examination of scalp biopsies was performed in all patients...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632906/improving-the-histologic-characterization-of-burn-depth
#17
Angela L F Gibson, Daniel D Bennett, Lauren J Taylor
BACKGROUND: Visual assessment of burn wound appearance is the standard of care to determine the depth of thermal injury but often incorrectly predicts wound healing potential. Histologic evaluation of hematoxylin and eosin (H&E) stained burn tissue is prone to subjectivity and is challenging for the novice. Lactate dehydrogenase (LDH) staining may offer a simplified and consistent technique to identify burn tissue viability. METHODS: Thirty tissue samples were obtained from six patients undergoing surgical excision for clinically determined deep partial thickness or full thickness burns...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28632903/immunohistochemical-dissection-of-cystic-panfolliculoma-focusing-on-the-expression-of-multiple-hair-follicle-lineage-markers-with-an-insight-into-the-pathogenesis
#18
Masahiro Fukuyama, Yohei Sato, Yoshimi Yamazaki, Manabu Ohyama
Panfolliculoma (PF) is a rare benign tumor with signs of differentiation toward all components of the hair follicle (HF). Cystic panfolliculoma (CPF) is a subset of PF with histological similarity to trichofolliculoma making the differential diagnosis difficult in some cases. Immunohistopathological investigations of PF have been reported; however, previous studies focused mostly on the expression profile of the outer root sheath markers. A panel of antibodies was developed and used for the detection of the expression of cytokeratin (CK) 10, CK13, CK14, CK15, hair-hard keratin (AE13), and EpCAM within the lesion, supporting the differentiation of all epithelial lineages of the HF and the diagnosis of CPF...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28628281/genomic-analysis-of-melanoma-evolution-following-a-30-year-disease-free-interval
#19
Jerry J Miller, Kristopher A Lofgren, Sarah R Hughes, Steven E Cash, Paraic A Kenny
Ultra-late melanoma recurrence is infrequent, poorly understood and, in most cases, difficult to unambiguously distinguish from a new primary melanoma. We identified a patient with a second melanoma diagnosed after a 30 year disease-free interval, and sought to determine if this new lesion was a recurrence of the original melanoma. Here we report the genomic sequence analysis of the exomes of two melanoma lesions isolated from the same individual in 1985 and 2015, and their comparison to each other and to the germline DNA of the patient...
June 19, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28628256/cutaneous-involvement-in-luteinized-thecomas-with-sclerosing-peritonitis-ltsp-a-new-finding-in-a-rare-syndrome
#20
Jonathan D Ho, Jag Bhawan, Michael J O'Brien, Lynne J Goldberg
Luteinized thecomas with sclerosing peritonitis (LTSP) is a rare disease characterized by ovarian luteinized thecomas and associated fibrosing peritonitis. Cutaneous involvement has never been reported. We report a case of classical LTSP with skin involvement, outlining the clinical and histopathologic features of this novel presentation of a rare syndrome.
June 19, 2017: Journal of Cutaneous Pathology
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