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Journal of Cutaneous Pathology

Asude Kara Polat, Muge Gore Karaali, Asli Vefa Turgut Erdemir, Ayse Esra Koku Aksu, Cem Leblebici, Mehmet Salih Gurel
Superficial acral fibromyxoma (SAFM) is an uncommon mesencyhmal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant neoplasms. We report a case of SAFM in a rare localization in the heel with a new entity on dermoscopy.
February 15, 2018: Journal of Cutaneous Pathology
James Abbott, Meghan Buckley, Laura A Taylor, George Xu, Giorgos Karakousis, Brian J Czerniecki, Phyllis A Gimotty, Paul J Zhang
AIMS: To further characterize the micromorphometric immunological pattern to metastatic melanoma in SLN biopsies and completion lymph node (CLN) dissections and their relation to 5-year overall survival. METHODS: Retrospective cohort of 49 patients from 1996 to 2005 with a positive SLN who underwent CLN dissection were studied. Micromorphometric characteristics included: follicular center count per profile (FCC), sinus histiocytosis, metastatic size, tumor infiltrating lymphocytes (intranodal), paracortial dendritic cells, germinal center reaction, and morphology...
February 15, 2018: Journal of Cutaneous Pathology
Kristin Torre, Preeti Jhorar, Rong Wu, John Pfeifer, Zendee Elaba, Michael Murphy
BACKGROUND: We evaluated how dermatopathologists are employing molecular testing in the setting of neoplastic skin diseases, and assess their opinions of the broader role and utility of molecular technologies in clinical practice. METHODS: A 15-question online survey was sent to Fellows of the American Society of Dermatopathology in April 2017. RESULTS: One hundred and thirty-six dermatopathologists completed the survey (response rate = 16%)...
February 13, 2018: Journal of Cutaneous Pathology
M Llamas-Velasco, Y C Pérez-Gónzalez, E Daudén, A Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. DESIGN: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
Nicholas Bercovici, Kristen Russomanno, Frank Santoro, Christopher Scola, Michael Murphy, Zendee Elaba
Injection drug abuse (IDA) is known to cause a spectrum of systemic and cutaneous complications. Despite the increasing incidence of IDA around the world, there is a paucity of literature discussing cutaneous complications from a dermatopathologic perspective. We present a case of a 35-year-old male with a complex medical history of Von Willebrand disease, Behcet's disease and diverticular disease. Following a sigmoidectomy/colostomy for diverticular perforation, he presented with fever and an indurated right arm displaying livedoid purpura...
February 12, 2018: Journal of Cutaneous Pathology
Aristea Stravodimou, Vassiliki Tzelepi, Helen Papadaki, Athanasia Mouzaki, Sophia Georgiou, Maria Melachrinou, Eleni P Kourea
BACKGROUND: Tumor infiltrating lymphocytes (TILs) represent important regulators of carcinogenesis. Cutaneous invasive squamous cell carcinoma (inSCC) develops through precursor lesions, namely in situ squamous cell carcinoma (isSCC) and actinic keratosis (AK), representing a natural model of carcinogenesis. The study evaluates TIL subpopulations in inSCC and its precursors by comparing two semi-quantitative scoring systems, and assesses the presence of regulatory T-cells (Tregs) in these lesions...
February 8, 2018: Journal of Cutaneous Pathology
Marie Kenney, Elizabeth B Lester, Deborah L Cook
Inverted follicular keratosis is a benign follicular tumor. Tumors classically demonstrate lobulated, endophytic growth with squamous eddy formation. The histologic differential diagnosis includes irritated seborrheic keratosis, trichilemmoma, verruca vulgaris, squamous cell carcinoma, and keratoacanthoma. The clinical differential diagnosis includes verruca, molluscum contagiosum, follicular cyst, and squamous cell carcinoma. In the past, a predilection for the head and neck of elderly men has been reported...
February 8, 2018: Journal of Cutaneous Pathology
Chen Yao, Adrienne N Choksi, Philip M McLain
No abstract text is available yet for this article.
February 6, 2018: Journal of Cutaneous Pathology
Emily Lenczowski, Morgan L Wilson
Cutaneous aggregates of meningeal cells have been variously designated as cutaneous meningioma, meningeal heterotopia, and ectopic meningeal rest, with most cases occurring on the head and neck.1,2 We present an unusual dermal collection of meningeal, adipose, and smooth muscle tissue arising on the thigh of an adult.
February 5, 2018: Journal of Cutaneous Pathology
D Y Xie, C M Costello, H J Liang, B G Thomas, D J DiCaudo, A R Mangold
Despite advances in treatment and increased public awareness, the incidence of melanoma has dramatically increased over the last 50 years 1,2 . Primary and secondary prevention is critical for decreasing the incidence and improving outcomes in melanoma3 . A proper clinical and histopathological diagnosis is necessary for definitive management.
February 5, 2018: Journal of Cutaneous Pathology
Katelynn Campbell, Asangi R Kumarapeli, Neriman Gokden, Roni Michele Cox, Laura Hutchins, Jerad M Gardner
Melanoma may undergo dedifferentiation and sarcomatous transformation with loss of melanocytic markers. Dedifferentiated melanoma rarely forms true rhabdomyoblasts with skeletal muscle immunophenotype (rhabdomyosarcomatous heterologous component). A 52 year-old woman was diagnosed with invasive melanoma (Breslow depth 0.83 mm) of the upper back in 2012, treated by wide local excision only. In 2013, an axillary mass was excised to show metastatic melanoma with two morphologies: an epithelioid morphology expressing S100 and MART-1 and a spindled morphology with loss of melanocytic markers but strong expression of desmin...
February 5, 2018: Journal of Cutaneous Pathology
Nicolas Liaudet, Marylise Fernandez, Lionel Fontao, Gürkan Kaya, Rastine Merat
BACKGROUND: Prognostic markers for melanoma, particularly for stage II disease, are needed for the risk benefit evaluation of future adjuvant therapies. The mainly nuclear RNA-binding protein HuR regulates the protein expression of thousands of mRNAs, its own heterogeneous expression could therefore reflect tumor heterogeneity and plasticity. Here, we evaluate its quantification in primary melanoma as a marker of metastatic outcome. METHODS: We conducted an immunohistochemistry-based automated quantification of HuR nuclear expression heterogeneity in primary melanomas most with Breslow thickness ≥ 1 mm and calculated the dimensionless fourth moment, i...
February 2, 2018: Journal of Cutaneous Pathology
Hovik Ashchyan, Melinda Jen, Rosalie Elenitsas, Adam I Rubin
No abstract text is available yet for this article.
February 2, 2018: Journal of Cutaneous Pathology
Yen-Kai Huang, Cheng-Kuan Lin, Yu-Hung Wu
BACKGROUND: Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear. METHODS: We retrospectively reviewed demographics, clinical presentations, pathological patterns, and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis. RESULTS: A total of 107 cases were ascertained. Five major pathological patterns were identified: lichenoid (45/107, 42...
January 30, 2018: Journal of Cutaneous Pathology
Nathaniel A Slater, Paul B Googe
Sox10 is a robust and sensitive immunostain for melanocytic neoplasia. The strong nuclear signal, the clean background, and the limited expression in normal cutaneous structures make it a highly useful marker in the histopathologic evaluation of skin tumors.
January 27, 2018: Journal of Cutaneous Pathology
Sonal Muzumdar, Melissa Argraves, Arni Kristjansson, Katalin Ferenczi, Soheil S Dadras
Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun-damaged skin is challenging. The first-line immunostain is usually MART-1/Melan-A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART-1 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2-mm diameter fields in pigmented actinic keratosis (n=16), lichenoid keratosis (n=7), junctional melanocytic nevus (n=6), keratosis with atypical melanocytic proliferation (AMP, n=17) and MIS (n=10)...
January 26, 2018: Journal of Cutaneous Pathology
Amin A Hedayat, Joi B Carter, Frederick Lansigan, Robert E LeBlanc
There are exceedingly rare reports of patients with epidermotropic B-cell lymphomas. A subset presented with intermittent, variably pruritic papular eruptions and involvement of their spleens, peripheral blood, and bone marrow at the time of diagnosis. Furthermore, some experienced an indolent course despite dissemination of their lymphomas. We report a 66-year-old woman with a 12-year history of intermittent eruptions of nonpruritic salmon-colored papules on her torso and proximal extremities that occurred in winter and resolved with outdoor activity in spring...
January 26, 2018: Journal of Cutaneous Pathology
Silvija P Gottesman, Walter M Klein, Gregory A Hosler, Katy R Veprauskas, Patrick S Rush, Jerad M Gardner
Twitter, an online social media platform created in the spring of 2006, has now reached approximately 328 million active monthly users1 . It allows for rapid exchange of ideas in 140 character tweets.
January 25, 2018: Journal of Cutaneous Pathology
Aldo Galvez, Leonard Sperling
BACKGROUND: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) represent two entities that cause primary cicatricial alopecia. These entities are clinically different; nevertheless the literature suggests that FFA represents a form of LPP. The main argument in support of this hypothesis is that previous studies comparing the histologic findings have not found obvious differences between these diseases. METHODS: Our objective was to more critically compare and contrast 20 histologic findings of these diseases in a large number of patients in order to determine any significant histologic differences between LPP and FFA...
January 25, 2018: Journal of Cutaneous Pathology
A Kailas, D M Elston, S E Crater, C A Cerruto
Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy was performed which revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Clinical exam revealed no other evidence of lymphoma, the patient denied constitutional symptoms, and routine blood work was normal. The patient is healthy and doing well 28 months after her first visit...
January 25, 2018: Journal of Cutaneous Pathology
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