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Journal of Cutaneous Pathology

Victoria Alegría-Landa, Margarita Jo Velasco, Lucía Prieto-Torres, Luis Requena
Folliculo-sebaceous hamartomas comprise a series of entities whose boundaries are imprecise. We present the clinical case of a folliculo-sebaceous cystic hamartoma of genital localization where the diagnosis was established based on the epithelial proliferation, but mostly, on the characteristic stroma. Because this lesion lacked of the cystic component, we mention the most frequent differential diagnoses and review the literature of the few cases published on this infrequent localization.
February 17, 2017: Journal of Cutaneous Pathology
Edmund Wee, Robert I Kelly
No abstract text is available yet for this article.
February 15, 2017: Journal of Cutaneous Pathology
Shannan E McCann, Scott R Dalton, Todd T Kobayashi
Bilateral lower extremity inflammatory lymphedema (BLEIL) is a recently described condition that presents with exquisite tenderness, erythema, and edema of the lower leg, ankle and dorsal foot resembling an acute cellulitis. It was first reported in healthy, young adult military basic trainees with a normal body mass index during the first 72 hours of arrival to basic training. It occurs while standing at attention for many hours, and shows rapid resolution with elevation and rest. We report an additional case of BLEIL and describe the histopathology of this case and two of the previously reported cases...
February 14, 2017: Journal of Cutaneous Pathology
Brianne H Daniels, Jennifer S Ko, J Jordi Rowe, Erinn Downs-Kelly, Steven D Billings
BACKGROUND: We have encountered cases of postradiation angiosarcoma (PRAS) histologically mimicking radiation dermatitis. METHODS: Cases of PRAS from institutional/consultation archives from 2006-2016 were reviewed. For inclusion, tumors had to have inapparent/subtle tumor at low magnification and scattered individual tumor cells resembling radiation fibroblasts. Prior ancillary studies were reviewed, with additional immunostains performed as needed. RESULTS: Ten met criteria...
February 7, 2017: Journal of Cutaneous Pathology
Masoud Asgari, Sheng Chen
No abstract text is available yet for this article.
February 6, 2017: Journal of Cutaneous Pathology
Thomas N Helm, Aries Y Liu-Helm
No abstract text is available yet for this article.
February 6, 2017: Journal of Cutaneous Pathology
Ari Morimoto, Ko-Ron Chen
No abstract text is available yet for this article.
February 6, 2017: Journal of Cutaneous Pathology
William A Berger, Monica Townsend Kraft, Michael J Murphy, Zendee Elaba
No abstract text is available yet for this article.
February 2, 2017: Journal of Cutaneous Pathology
Yuan Yu Michael Huang, Travis Vandergriff
No abstract text is available yet for this article.
February 1, 2017: Journal of Cutaneous Pathology
Giuseppe Angelico, Pietro Gangemi, Rosario Caltabiano
We herein report a patient who clinically presented with a pigmented, flat plaque in the vulvar area. Histological examination showed a benign lesion mainly composed of tubular and cystic glands with apocrine differentiation. The most striking histological feature was the deposition of finely granular melanin pigment both in the epithelial cells and in the luminal surface of the glands. In addition, Melan-A immunostaining demonstrated the presence of numerous melanocytes within the lesion suggesting that the pigment deposition was secondary to colonization of the lesion by melanocytes...
January 31, 2017: Journal of Cutaneous Pathology
Mark McInturff, Bradley Graham
Spindle cell lipoma is a benign lipomatous neoplasm that tends to occur near the upper back, or posterior neck of adult males. The tumor has characteristic histology with variably cellular spindle cell areas surrounding mature adipose tissue. With the classic clinical history diagnosis is usually straight forward. However, the location and or histology may not always be so classic, in which case immunohistochemical stains may be helpful. We present a case of spindle cell lipoma with prominent Verocay bodies and a review of the literature to draw attention to possible diagnostic pitfalls...
January 31, 2017: Journal of Cutaneous Pathology
Kana Mizuno, Nguyen Thi Hong Chuyen, Ikuko Ueda-Hayakawa, Hiroyuki Okamoto
Sarcoidosis is known to be involved in diseases with vasculitis as sarcoid vasculitis. However, vasculitis in cutaneous sarcoidal lesions is extremely rare. Here we describe a case of sarcoidosis with multiple annular skin lesions with granulomatous vasculitis. A 62-year-old female was diagnosed with sarcoidosis by chest-abdominal CT examination and laboratory tests. The skin lesions had appeared on her lower limbs 2 years before. Physical examination showed multiple infiltrated annular eruptions on the lower extremities...
January 24, 2017: Journal of Cutaneous Pathology
Thomas N Helm
The seventh edition of the American Joint Committee on Cancer (AJCC)'s staging manual identified tumor thickness, ulceration, and mitotic figures as important adverse prognostic factors for survival. Identification of a single mitosis prompted staging of a tumor as T1b and prompted consideration of sentinel lymph node biopsy (SLNB). Careful review of survival data has shown that the identification of mitotic figures in melanoma is not an independent variable but linked to thickness and ulceration. The updated eighth edition of the AJCC's cancer staging manual reflects this understanding by stratifying thin melanomas by depth of invasion and ulceration rather than including mitotic rate...
January 24, 2017: Journal of Cutaneous Pathology
Priscila Lie Tobouti, Isabel Olegário, Suzana Cantanhede Orsini Machado de Sousa
BACKGROUND: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In the present study vascular lesions occurring in the lips were retrieved from an Oral Pathology Service. METHODS: Among 5,600 biopsies, 131 cases were found. The following diagnoses were attributed: caliber-persistent artery, infantile hemangioma, vascular malformation, venous lake, thrombus, papillary endothelial hyperplasia, and pyogenic granuloma...
January 23, 2017: Journal of Cutaneous Pathology
Patrick O Emanuel, Garrett Desman, Ben Tallon
We report a highly unusual case of a primary cutaneous squamous cell carcinoma with intermixed enteric-type adenocarcinomatous dedifferentiation and a small component of undifferentiated mesenchymal differentiation. We believe this is the first time this form of phenotypic plasticity has been described in cutaneous squamous cell carcinoma.
January 23, 2017: Journal of Cutaneous Pathology
A Osio, M-D Vignon-Pennamen, F Pedeutour, C Le Maignan, F Koskas, C Lebbé, A Janin, M Battistella
A 62-year-old HIV-positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of FNCLCC grade III Undifferentiated Pleomorphic Sarcoma (UPS). aCGH showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the PDGFRa gene...
January 20, 2017: Journal of Cutaneous Pathology
Jeanne McFalls, Lauren Okon, Sarah Cannon, Jason B Lee
Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation (UVR) or a neoplastic process, namely, Merkel cell carcinoma (MCC) in-situ. The recent criteria that have been proffered to diagnose MCC in-situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells...
January 20, 2017: Journal of Cutaneous Pathology
Kiran Motaparthi
Three cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All three patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all three patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in one patient, the clinical impression included herpesvirus infection. Similar histologic and immunohistochemical findings were demonstrated in all three cases...
January 18, 2017: Journal of Cutaneous Pathology
Shakuntala H Mauzo, Michael Swaby, Michael Covinsky
High pressure paint injection injury is an uncommon but well-described injury. The histologic features of long-term paint injection injury with retained material are less recognized. A 46 year old male presented clinically as "recurrent giant cell tumor of tendon sheath". The right index finger demonstrated fusiform enlargement by a pigmented mass with diffuse infiltration into the soft tissue of the hand. Histologically the tumor showed multiple giant cells in a fibrotic stroma extending into the dermis. There were multiple types of foreign material including diffuse brown black pigment, weakly optically polarizing foreign material and white inclusions with a "train track" appearance...
January 18, 2017: Journal of Cutaneous Pathology
Mara Therese P Evangelista, Jeffrey P North
BACKGROUND: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117, and SOX-10 expression in cutaneous adnexal tumors. METHODS: Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular, and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10, and CD117 immunostaining...
January 18, 2017: Journal of Cutaneous Pathology
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