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Journal of Cutaneous Pathology

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https://www.readbyqxmd.com/read/28543636/loss-of-retinoblastoma-in-pleomorphic-fibroma-an-immunohistochemical-and-genomic-analysis
#1
Brian Hinds, Alfredo Agulló, Philip E LeBoit, Timothy H McCalmont, Jeffrey P North
BACKGROUND: Pleomorphic fibroma is a curious neoplasm that exhibits striking cytologic atypia, yet behaves in benign fashion. The cytologic features including single cells with pleomorphic nuclei and scattered giant cells resemble the neoplastic cells of pleomorphic lipoma, a tumor with known retinoblastoma (Rb) loss. METHODS: We assessed the demographic and histopathologic features of a cohort of 26 pleomorphic fibromas, including assessment with immunostaining for Rb, p16, and Ki-67...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28543532/intraepidermal-merkel-cell-carcinoma-a-case-series-of-a-rare-entity-with-clinical-follow-up
#2
George Jour, Phyu P Aung, Eduardo Rozas-Muñoz, Johnathan L Curry, Victor Prieto, Doina Ivan
BACKGROUND: Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous carcinoma. MCC involves typically dermis and although epidermotropism has been reported, MCC strictly intraepidermal or in situ (MCCIS) is exceedingly rare. Most of the cases of MCCIS described so far have associated other lesions, such as squamous or basal cell carcinoma, actinic keratosis, etc. Herein, we describe three patients with MCC strictly in situ, without a dermal component. METHODS: Our patients were elderly, two of the lesions involved the head and neck area and one was on a finger...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28543379/idiopathic-lymphoplasmacellular-mucositis-of-the-lips-a-case-report-and-review-of-the-literature
#3
Ren-Feng Liu, Chun-Bing Chen, Tseng-Tong Kuo, Wen-Hung Chung
Idiopathic lymphoplasmacellular mucositis (ILPM) is a group of disorders histologically characterized by dense infiltrates of lymphocytes and plasma cells in submucosa. These lesions are initially observed on the glans penis and vulva, and later on buccal mucosa, lips, gingiva, tongue, epiglottis, larynx, and other mucosal surfaces have also been reported. We have reviewed the previously reported cases of ILPM with lip involvement, outlining the clinical presentation, treatment and outcome of the entity to date...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28509428/including-langerhans-cell-histiocytosis-in-the-differential-diagnosis-of-skin-tumors-with-osteoclast-like-multinucleated-giant-cells
#4
LETTER
Tina Ho, Jennifer Oliver-Krasinski, Pierre Russo, Jesse Taylor, Jenna Streicher, Adam I Rubin
No abstract text is available yet for this article.
May 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28509329/a-case-of-combined-desmoplastic-trichoepithelioma-and-compound-melanocytic-nevus
#5
LETTER
Duygu Gulseren, Jessica M Kwock, James W Patterson
No abstract text is available yet for this article.
May 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28497640/polarizable-crystals-in-apocrine-sweat-gland-tumors-a-series-of-three-cases
#6
Gina Johnson, Jerad M Gardner, Sara C Shalin
Polarizable calcium oxalate (CaOx) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report three different cases of sweat gland tumors with polarizable crystals morphologically suggestive of CaOx: 1 apocrine hidrocystoma and 2 tubular apocrine adenomas. The histologic features were examined in 3 cases. Clinical presentation summary included 2 males and 1 female, ages 53 to 74, with lesions located on the left cheek, inferior vertex scalp and the left eyebrow...
May 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28497585/disseminated-cd8-positive-cd30-positive-cutaneous-lymphoproliferative-eruption-with-overlapping-features-of-mycosis-fungoides-and-primary-cutaneous-anaplastic-large-cell-lymphoma-following-remote-solitary-lesional-presentation
#7
Jonathan J Davick, Krishna Aj Mutgi, Karolyn A Wanat, Brian K Link, Vincent Liu
CD8-positive, CD30-positive cutaneous lymphoproliferative disorders comprise a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma, mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma, and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic, and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous anaplastic large cell lymphoma, as well as features of lymphomatoid papulosis...
May 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28493477/superficial-basal-cell-carcinoma-a-comparison-of-superficial-only-subtype-with-superficial-combined-with-other-subtypes-by-age-sex-and-anatomic-site-in-3-150-cases
#8
John H Pyne, Esther Myint, Elizabeth M Barr, Simon P Clark, Michael David, Renua Na, Ruihang Hou
BACKGROUND: Basal Cell Carcinoma (BCC) may present as superficial subtype alone (sBCC) or superficial combined with other subtypes. OBJECTIVE: To compare sBCC without or with other BCC subtypes by age, sex and anatomic site. METHODS: We retrospectively collected superficial BCC with the above characteristics from an Australian centre during 2009-14. RESULTS: We recorded 1,528 sBCC and 1,622 superficial BCC combined with other BCC subtype cases...
May 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28493354/acral-angioleiomyoma-with-tumoral-calcinosis-a-complication-of-the-insertional-achilles-tendinopathy
#9
LETTER
Vicente Sabater Marco, Sandra Barberá Bosch, Lorena Valdivieso Almeida
No abstract text is available yet for this article.
May 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28439960/preference-for-the-term-pilomatrical-carcinoma-with-melanocytic-hyperplasia
#10
LETTER
Caroline Perez, Maya Debbaneh, David Cassarino
No abstract text is available yet for this article.
April 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28436041/cd117-immunohistochemistry-in-sarcomatoid-porocarcinoma
#11
LETTER
Gauri Panse, Antonio Subtil
No abstract text is available yet for this article.
April 24, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28429507/mucinous-hidradenoma-in-a-child-a-case-report-and-review-of-the-literature
#12
Aadil Ahmed, Wendy Kim, Jodi Speiser
Hidradenomas are benign tumors of the sweat glands that are rarely reported in childhood. The presence of mucinous change in hidradenomas, which consists of variable numbers of mucin-rich goblet cells, is occasionally observed in some adult clinical practices. However, it has not been previously reported in the pediatric population. Herein, we present a unique case of a mucinous hidradenoma presenting on the thigh of a 3-year old boy. The clinical presentation and histological features of the case, along with a literature review of published case reports of pediatric hidradenomas are described...
April 21, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28429464/inflammatory-features-of-frontal-fibrosing-alopecia
#13
Sophia A Ma, Sotonye Imadojemu, Kenneth Beer, John T Seykora
INTRODUCTION: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia typically occurring in post-menopausal women. The etiology and pathophysiology of FFA is poorly understood but thought to be immune mediated. This study aims to further explore the extent of fibrosis and the inflammatory microenvironment by characterizing Langerhans cells (LCs), helper T cells, cytotoxic T cells, and B cells near hair follicles in FFA. METHODS: 11 paraffin-embedded tissues from patients with a clinical and histopathologic diagnosis of FFA were selected for immunohistochemical studies using CD3, CD4, CD8, CD1a, and CD20...
April 21, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28425108/coexistence-of-psoriasis-and-epidermolysis-bullosa-acquisita-evaluation-of-the-integrity-of-the-basement-membrane
#14
LETTER
Sun Young Moon, Dong Hyuk Eun, Han Jin Jung, Jun Young Kim, Tae-In Park, Weon Ju Lee, Seok-Jong Lee, Do Won Kim, Man-Hoon Han, Yong Hyun Jang
No abstract text is available yet for this article.
April 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28425107/metastatic-urothelial-carcinoma-presenting-as-carcinoma-erysipeloides-cup-q-028-2017
#15
Shane A Grace, Matthew R Livingood, Alan S Boyd
Carcinoma erysipeloides (CE) is a rare but distinctive form of cutaneous metastasis that clinically resembles erysipelas. Herein, we report a case of CE as the presenting feature of recurrent urothelial carcinoma.
April 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28419495/giant-proliferating-trichilemmal-cyst-arising-from-a-nevus-sebaceus-growing-for-thirty-years
#16
Scott F Lindsey, Divya Aickara, Alexandra Price, Janelle Pavlis, Erin X Wei, George Elgart, Jeong Hee Cho-Vega
Nevus sebaceus of Jadassohn, a congenital cutaneous hamartoma, has the potential to develop into various epidermal adnexal-origin neoplasms. While the most common neoplasms are trichoblastoma or syringocystadenoma, proliferating trichilemmal cysts are exceptionally rare. We report a case of a 63-year-old Cuban male with a giant proliferating trichilemmal cyst arising from a nevus sebaceus on the right shoulder which had been growing for 30 years. Proliferating trichilemmal cysts arising from nevus sebaceus cases are difficult to diagnose clinically and histologically since they are very rare and have not been defined by exact diagnostic criteria...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28417484/well-differentiated-neuroendocrine-tumors-in-skin-terminology-and-diagnostic-utility-of-cytokeratin-5-6-and-p63
#17
Gauri Panse, Shawn E Cowper, David J Leffell, Melissa Pulitzer, Christine J Ko
BACKGROUND: Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK 5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK 5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28403573/desmoplastic-melanoma-may-mimic-a-cutaneous-peripheral-nerve-sheath-tumor-report-of-3-challenging-cases
#18
Isidro Machado, Beatriz Llombart, Julia Cruz, Víctor Traves, Celia Requena, Eduardo Nagore, Antonina Parafioriti, Carlos Monteagudo, Antonio Llombart-Bosch
Desmoplastic melanoma (DM) and cutaneous malignant peripheral nerve sheath tumors (MPNST) reveal histological and immunohistochemical similarities, including S100 positivity and negative staining for conventional melanocytic markers. We present 3 cases of cutaneous S100-positive spindle cell tumors in elderly patients, in which first findings led to initial misdiagnoses as cutaneous MPNST and benign peripheral sheath nerve tumor (neurofibroma). The identification of adjacent atypical melanocytic hyperplasia in the overlying skin along with tumor cell proliferation, also in the superficial dermis, the neurotropic component and the absence of any relationship between the tumor and a major nerve, pre-existing neural benign tumor or the existence of stigmata suggestive of neurofibromatosis raised consideration of a DM...
April 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28403527/basal-cell-carcinoma-cd56-and-cytokeratin-5-6-staining-patterns-in-the-differential-diagnosis-with-merkel-cell-carcinoma
#19
Gauri Panse, Jennifer M McNiff, Christine J Ko
BACKGROUND: Basal cell carcinoma (BCC) can resemble Merkel cell carcinoma (MCC) on histopathological examination and while CK20 is a useful marker in this differential, it is occasionally negative in MCC. CD56, a sensitive marker of neuroendocrine differentiation, is sometimes used to identify MCC, but has been reportedly variably positive in BCC as well. In contrast, CK5/6 consistently labels BCC but is not expressed in neuroendocrine tumors. METHODS: We evaluated twenty cases of BCC for the pattern of CD56 and cytokeratin 5/6 (CK5/6) staining, hypothesizing that these two stains could differentiate BCC from MCC in difficult cases...
April 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28401581/seborrheic-keratosis-with-basal-clear-cells-report-of-a-case-and-review-of-the-literature
#20
LETTER
Carolina Manzotti, Juan José Ríos Martín, Álvaro Gutiérrez Domingo, Juan Luis Gutiérrez Cierco, Ricardo González Cámpora
No abstract text is available yet for this article.
April 12, 2017: Journal of Cutaneous Pathology
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